Haiqing Ni, Lei Cao, Zhihai Wu, Li Wang, Shuaixiang Zhou, Xiaoli Guo, Yarong Gao, Hua Jing, Min Wu, Yang Liu, Jiazheng Ding, Pan Zhang, Ying Zhou, Bingliang Chen, Yao Xiong, Jiya Sun, Bianka Prinz, Hemanta Baruah, James Geoghegan, Michael Yu, Weiwei Wu, Junjian Liu
CD47 is a widely expressed cell-surface protein that regulates phagocytosis mediated by cells of the innate immune system, such as macrophages and dendritic cells. CD47 serves as the ligand for a receptor on these innate immune cells, signal regulatory protein (SIRP)-α, which in turn inhibits phagocytosis. Several targeted CD47 therapeutic antibodies have been investigated clinically; however, how to improve its therapeutic efficacy remains unclear. Herein, we developed a CD47 blocking antibody, named IBI188, that could specifically block the CD47-SIRP-α axis, which transduces the "don't eat me" signal to macrophages...
February 2022: Cancer Immunology, Immunotherapy: CII