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https://www.readbyqxmd.com/read/28943293/chronic-stress-induced-disturbances-in-laminin-a-significant-contributor-to-modulating-microglial-pro-inflammatory-tone
#1
Giovanni Pietrogrande, Nishani Mabotuwana, Zidan Zhao, Abdolhoseini Mahmoud, Sarah J Johnson, Michael Nilsson, Frederick R Walker
Over the last decade, evidence supporting a link between microglia enhanced neuro-inflammatory signalling and mood disturbance has continued to build. One issue that has not been well addressed yet are the factors that drive microglia to enter into a higher pro-inflammatory state. The current study addressed the potential role of the extracellular matrix protein Laminin. C57BL6 adult mice were either exposed to chronic stress or handled for 6 consecutive weeks. Changes in Laminin, microglial morphology and pro-inflammatory cytokine expression were examined in tissue obtained from mice exposed to a chronic restraint stress procedure...
September 21, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28942246/inhibition-of-hepatocyte-nuclear-factor-1b-induces-hepatic-steatosis-through-dpp4-nox1-mediated-regulation-of-superoxide
#2
Zi Long, Meng Cao, Shuhao Su, Guangyuan Wu, Fansen Meng, Hao Wu, Jiangzheng Liu, Weihua Yu, Kamran Atabai, Xin Wang
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder that is closely associated with insulin resistance and type 2 diabetes. Previous studies have suggested that hepatocyte nuclear factor 1b (HNF1b) ameliorates insulin resistance. However, the role of HNF1b in the regulation of lipid metabolism and hepatic steatosis remains poorly understood. We found that HNF1b expression was decreased in steatotic livers. We injected mice with lentivirus (LV) expressing HNF1b shRNA to generate mice with hepatic knockdown of HNF1b...
September 20, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28942145/gut-microbial-metabolite-tmao-contributes-to-renal-dysfunction-in-a-mouse-model-of-diet-induced-obesity
#3
Guangping Sun, Zhongmin Yin, Naiquan Liu, Xiaohui Bian, Rui Yu, Xiaoxiao Su, Beiru Zhang, Yanqiu Wang
Emerging evidence shows that obesity induces renal injury and is an independent risk factor for the development of chronic kidney disease (CKD), even without diabetes or hyperglycemia. Although multiple metabolic factors have been suggested to account for obesity-associated renal injury, the precious underlying mechanisms are not completely understood. Recent study shows that increased trimethylamine N-Oxide (TMAO), a gut microbiota-generated metabolite, directly contributes to renal interstitial fibrosis and dysfunction...
September 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28940209/chronic-psychological-stress-promotes-lung-metastatic-colonization-of-circulating-breast-cancer-cells-by-decorating-a-pre-metastatic-niche-through-activating-%C3%AE-adrenergic-signaling
#4
Hongyu Chen, Dan Liu, Liang Guo, Xiang Cheng, Ning Guo, Ming Shi
Numerous studies have indicated that primary tumors induce formation of a pre-metastatic niche in distant organs by secreting tumor-derived factors. The present study shows that pre-exposure to chronic stress enhanced lung colonization efficiency by circulating tumor cells, suggesting that chronic stress critically influences pre-metastatic lungs before arrival of disseminated tumor cells. Ablation of the sympathetic nerve function by 6-OHDA or blockage of the β-adrenergic signaling by propranolol remarkably suppressed stress-induced lung metastasis...
September 22, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28939429/quercetin-ameliorates-chronic-unpredicted-stress-induced-behavioral-dysfunction-in-male-swiss-albino-mice-by-modulating-hippocampal-insulin-signaling-pathway
#5
Vineet Mehta, Tiratha Raj Singh, Malairaman Udayabanu
Chronic stress is associated with impaired neurogenesis, neurodegeneration and behavioral dysfunction, whereas the mechanism underlying stress-mediated neurological complication is still not clear. In the present study, we aimed to investigate whether chronic unpredicted stress (CUS) mediated neurological alterations are associated with impaired hippocampal insulin signaling or not, and studied the effect of quercetin in this scenario. Male Swiss albino mice were subjected to 21day CUS, during which 30mg/kg quercetin treatment was given orally...
September 19, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28939260/adolescent-social-isolation-stress-unmasks-the-combined-effects-of-adolescent-exercise-and-adult-inflammation-on-hippocampal-neurogenesis-and-behaviour
#6
Cara M Hueston, John F Cryan, Yvonne M Nolan
Hippocampal neurogenesis and associated cognitive behaviours are regulated by a number of factors including stress, inflammation, and exercise. However, the interplay between these factors remains relatively unexplored, especially across the lifespan. In the current study, the effect of social isolation stress during the adolescent period on neurogenesis and hippocampal dependent cognitive behaviours was examined. This period of the lifespan has been demonstrated to be an important time for hippocampal growth and plasticity, during which changes to hippocampal neurogenesis may have long lasting effects...
September 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28935932/cannabidiol-attenuates-alcohol-induced-liver-steatosis-metabolic-dysregulation-inflammation-and-neutrophil-mediated-injury
#7
Yuping Wang, Partha Mukhopadhyay, Zongxian Cao, Hua Wang, Dechun Feng, György Haskó, Raphael Mechoulam, Bin Gao, Pal Pacher
Cannabidiol (CBD) is a non-psychoactive component of marijuana, which has anti-inflammatory effects. It has also been approved by FDA for various orphan diseases for exploratory trials. Herein, we investigated the effects of CBD on liver injury induced by chronic plus binge alcohol feeding in mice. CBD or vehicle was administered daily throughout the alcohol feeding study. At the conclusion of the feeding protocol, serums samples, livers or isolated neutrophils were utilized for molecular biology, biochemistry and pathology analysis...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935573/acrolein-disrupts-tight-junction-proteins-and-causes-er-stress-mediated-epithelial-cell-death-leading-to-intestinal-barrier-dysfunction-and-permeability
#8
Wei-Yang Chen, Min Wang, Jingwen Zhang, Shirish S Barve, Craig J McClain, Swati Joshi-Barve
Increasing evidence suggests that environmental and dietary factors can affect intestinal epithelial integrity leading to gut permeability and bacterial translocation. Intestinal barrier dysfunction is a pathogenic process associated with many chronic disorders. Acrolein is an environmental and dietary pollutant and a lipid-derived endogenous metabolite. The impact of acrolein on the intestine has not been investigated before and is evaluated in this study, both in vitro and in vivo. Our data demonstrate that oral acrolein exposure in mice caused damage to the intestinal epithelial barrier, resulting in increased permeability and subsequently translocation of bacterial endotoxin-LPS into the blood...
September 18, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28933492/the-hepatoprotective-effect-of-the-probiotic-clostridium-butyricum-against-carbon-tetrachloride-induced-acute-liver-damage-in-mice
#9
Jiaming Liu, Yaoyang Fu, Hao Zhang, Jindan Wang, Jing Zhu, Yaqi Wang, Yuegui Guo, Guocan Wang, Tianqi Xu, Maoping Chu, Fangyan Wang
Previous studies have revealed that the probiotic Clostridium butyricum (C. butyricum) can attenuate cirrhosis in chronic non-alcoholic liver disease. However, the effects of C. butyricum on acute liver injury (ALI) remain unclear. Therefore, the present study aims to examine the hepatoprotective effects and the underlying mechanisms employed by C. butyricum in a carbon tetrachloride (CCl4)-induced ALI murine model. Here, we evaluated the survival rate and the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), anti-oxidants, cytokines and the gut microbiota to elucidate the potential mechanisms by which C...
September 21, 2017: Food & Function
https://www.readbyqxmd.com/read/28930750/tauroursodeoxycholic-acid-reduces-arterial-stiffness-and-improves-endothelial-dysfunction-in-type-2-diabetic-mice
#10
Micah L Battson, Dustin M Lee, Dillon K Jarrell, Shoufei Hou, Kayl E Ecton, Anna B Phan, Christopher L Gentile
BACKGROUND/AIMS: Endoplasmic reticulum (ER) stress has emerged as a potential mechanism contributing to diabetes and its comorbidities. However, the importance of ER stress in diabetic vascular dysfunction is unclear. The purpose of this study was to examine the effects of the ER stress inhibitor, tauroursodeoxycholic acid (TUDCA), on arterial stiffness and endothelial dysfunction in type 2 diabetic mice. METHODS: Carotid and mesenteric artery endothelial function were assessed via ex vivo pressure myography, and arterial stiffness was measured by aortic pulse wave velocity...
September 21, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28930153/selective-hdl-raising-human-apo-a-i-gene-therapy-counteracts-cardiac-hypertrophy-reduces-myocardial-fibrosis-and-improves-cardiac-function-in-mice-with-chronic-pressure-overload
#11
Ruhul Amin, Ilayaraja Muthuramu, Joseph Pierre Aboumsallem, Mudit Mishra, Frank Jacobs, Bart De Geest
Epidemiological studies support an independent inverse association between high-density lipoprotein (HDL) cholesterol levels and heart failure incidence. The effect of selective HDL-raising adeno-associated viral serotype 8-human apolipoprotein (apo) A-I (AAV8-A-I) gene transfer on cardiac remodeling induced by transverse aortic constriction (TAC) was evaluated in C57BL/6 low-density lipoprotein receptor-deficient mice. Septal wall thickness and cardiomyocyte cross-sectional area were reduced by 16.5% (p < 0...
September 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28926614/effect-of-chronic-stress-on-running-wheel-activity-in-mice
#12
Evan DeVallance, Dale Riggs, Barbara Jackson, Travis Parkulo, Stanley Zaslau, Paul D Chantler, I Mark Olfert, Randy W Bryner
Acute and chronic stress have been reported to have differing effects on physical activity in rodents, but no study has examined a chronic stress protocol that incorporates stressors often experienced by rodents throughout a day. To examine this, the effects of the Unpredictable Chronic Mild Stress (UCMS) protocol on voluntary running wheel activity at multiple time points, and/or in response to acute removal of chronic stress was determined. Twenty male Balb/c mice were given access and accustomed to running wheels for 4 weeks, after which they were randomized into 2 groups; exercise (EX, n = 10) and exercise with chronic stress using a modified UCMS protocol for 7 hours/day (8:00 a...
2017: PloS One
https://www.readbyqxmd.com/read/28926000/the-bdnf-val66met-polymorphism-regulates-glucocorticoid-induced-corticohippocampal-remodeling-and-behavioral-despair
#13
M Notaras, X Du, J Gogos, M van den Buuse, R A Hill
The BDNF Val66Met polymorphism has been associated with sensitivity to stress and affective disorders. We therefore sought to model the inter-causality of these relationships under controlled laboratory conditions. We subjected humanized BDNF Val66Met (hBDNF(Val66Met)) transgenic mice to a history of stress, modeled by chronic late-adolescent corticosterone (CORT) exposure, before evaluating affective-related behavior using the forced-swim test (FST) in adulthood. While hBDNF(Met/Met) mice had a depression-like phenotype in the FST irrespective of CORT, hBDNF(Val/Val) wildtype mice had a resilient phenotype but developed an equally robust depressive-like phenotype following CORT...
September 19, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28924552/schisandra-sphenanthera-extract-wuzhi-tablet-protects-against-chronic-binge-and-acute-alcohol-induced-liver-injury-by-regulating-the-nrf2-are-pathway-in-mice
#14
Xuezhen Zeng, Xi Li, Chenshu Xu, Fulin Jiang, Yufei Mo, Xiaomei Fan, Yaoting Li, Yiming Jiang, Dongshun Li, Min Huang, Huichang Bi
Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available. Wuzhi Tablet (WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepato-protective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding...
September 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28921671/methyl-jasmonate-ameliorates-unpredictable-chronic-mild-stress-induced-behavioral-and-biochemical-alterations-in-mouse-brain
#15
Adaeze Adebesin, Abayomi M Ajayi, Elizabeth O Olonode, Osarume Omorogbe, Solomon Umukoro
Preclinical Research The effects of methyl jasmonate (MJ; 5, 10, 20 mg/kg, i.p), a natural product widely used for the relief of stress, depression, and exhaustion on unpredictable chronic mild stress (UCMS)-induced depression-like behaviors in mice was assessed and compared to those of imipramine (IMP; 10 mg/kg, i.p). MJ and IMP were given 30 min before exposure to UCMS with the procedure repeated daily for 2 weeks; 24 h after the stress session, the tail suspension test (TST) and sucrose preference test were assessed...
September 17, 2017: Drug Development Research
https://www.readbyqxmd.com/read/28917185/ghrelin-and-hypothalamic-npy-agrp-expression-in-mice-are-affected-by-chronic-early-life-stress-exposure-in-a-sex-specific-manner
#16
K Y Yam, S R Ruigrok, I Ziko, S N De Luca, P J Lucassen, S J Spencer, A Korosi
Early-life stress (ES) is a risk factor for metabolic disorders (e.g. obesity) with a notoriously higher prevalence in women compared to men. However, mechanisms underlying these effects remain elusive. The development of the hypothalamic feeding and metabolic regulatory circuits occurs mostly in the early sensitive postnatal phase in rodents and is tightly regulated by the metabolic hormones leptin and ghrelin. We have previously demonstrated that chronic ES reduces circulating leptin and alters adipose tissue metabolism early and later in life similarly in both sexes...
September 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28912681/divergence-in-morris-water-maze-based-cognitive-performance-under-chronic-stress-is-associated-with-the-hippocampal-whole-transcriptomic-modification-in-mice
#17
Seung H Jung, Milene L Brownlow, Matteo Pellegrini, Ryan Jankord
Individual susceptibility determines the magnitude of stress effects on cognitive function. The hippocampus, a brain region of memory consolidation, is vulnerable to stressful environments, and the impact of stress on hippocampus may determine individual variability in cognitive performance. Therefore, the purpose of this study was to define the relationship between the divergence in spatial memory performance under chronically unpredictable stress and an associated transcriptomic alternation in hippocampus, the brain region of spatial memory consolidation...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28912499/role-of-dopamine-d2-receptor-in-stress-induced-myelin-loss
#18
Mi-Hyun Choi, Ji Eun Na, Ye Ran Yoon, Hyo Jin Lee, Sehyoun Yoon, Im Joo Rhyu, Ja-Hyun Baik
Dopaminergic systems play a major role in reward-related behavior and dysregulation of dopamine (DA) systems can cause several mental disorders, including depression. We previously reported that dopamine D2 receptor knockout (D2R(-/-)) mice display increased anxiety and depression-like behaviors upon chronic stress. Here, we observed that chronic stress caused myelin loss in wild-type (WT) mice, while the myelin level in D2R(-/-) mice, which was already lower than that in WT mice, was not affected upon stress...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911970/mesenchymal-stem-cells-alleviate-oxidative-stress-induced-mitochondrial-dysfunction-in-the-airways
#19
Xiang Li, Charalambos Michaeloudes, Yuelin Zhang, Coen H Wiegman, Ian M Adcock, Qizhou Lian, Judith C W Mak, Pankaj K Bhavsar, Kian Fan Chung
BACKGROUND: Oxidative stress-induced mitochondrial dysfunction may contribute to inflammation and remodeling in chronic obstructive pulmonary disease (COPD). Mesenchymal stem cells (MSCs) protect against lung damage in animal models of COPD. It is unknown whether these effects occur through attenuating mitochondrial dysfunction in airway cells. OBJECTIVE: To examine the effect of induced-pluripotent stem cell-derived MSCs (iPSC-MSCs) on oxidative stress-induce mitochondrial dysfunction in human airway smooth muscle cells (ASMCs) in vitro and in mouse lungs in vivo...
September 11, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28911850/activation-of-indoleamine-2-3-dioxygenase-pathway-by-olanzapine-augments-antidepressant-effects-of-venlafaxine-in-mice
#20
Jaya Thomas, Razia Khanam, Divya Vohora
Recent clinical studies report antipsychotics as a better option to augment the action of antidepressants in treatment resistant cases. However, the proper mechanisms underlying the antidepressant effect of antipsychotics is still not clear. Indolamine 2, 3 dioxygenase (IDO) pathway is considered to be an important pathway in pro-inflammatory cytokine associated stress-induced depression. The present study investigated the antidepressant effect of venlafaxine, olanzapine and their combinations in chronic forced-swim stress-induced depression in mice...
August 31, 2017: Psychiatry Research
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