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https://www.readbyqxmd.com/read/29237567/integrated-metabolomics-and-proteomics-analysis-of-hippocampus-in-a-rat-model-of-depression
#1
Yuqing Zhang, Shuai Yuan, Juncai Pu, Lining Yang, Xinyu Zhou, Lanxiang Liu, Xiaofeng Jiang, Hanping Zhang, Teng Teng, Lu Tian, Peng Xie
Major depressive disorder (MDD) is a prevalent and serious mental disorder with high rates of suicide and disability. However, the underlying pathogenesis of MDD is complicated and remains largely unclear. An integrated analysis of multiple types of omics data may improve comprehensive understanding of the entire molecular mechanism of MDD. In this study, we applied an integrated analysis of gas chromatography/mass spectrometry (GC-MS)-based metabolomics and isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics to investigate changes in the hippocampus in the chronic unpredictable mild stress (CUMS) rat model of depression...
December 10, 2017: Neuroscience
https://www.readbyqxmd.com/read/29231507/-effect-of-acupuncture-treatment-on-gene-expression-of-neurotransmitters-of-brain-tissue-in-rats-with-post-stroke-depression
#2
Wei Xiao, Xianbao Zhang, Zhen Wang, Yan Wang, Xiaoli Guo, Ling He, Fajun Liang, Huixing Hu
OBJECTIVE: To observe the effects of acupuncture on mRNA of the neurotransmitter serotonin transporter (5-HTT), 5-HT1Areceptor (5-HT1AR), norepinephrineα2 receptor (NEα2R) in brain tissue in rats with post-stroke depression. METHODS: Forty male SD rats were randomly divided into a normal group, a model group, a medication group and an acupuncture group, 10 rats in each one. The model of post-stroke depression was established by occlusion of middle cerebral artery and chronic unpredictable mild stress method...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231480/-effects-of-electroacupuncture-on-synaptic-plasticity-in-hippocampal-ca3-area-of-rats-with-chronic-stress-depression
#3
Long Wang, Di Zhang, Xusheng Tian, Dan Liu, Xiaowei Sun, Yanqiu Li, Cuijuan Wang, Ming Ma, Dongjie Li, Zhongren Sun
OBJECTIVE: To explore the effects of electroacupuncture (EA) on behavioral function and synaptic plasticity in hippocampal CA3 area in rats with chronic stress depression. METHODS: According to the random number table method, 144 SD male rats were assigned into a blank group, a model group, an EA group and a fluoxetine group, then each group was divided into a 7 d subgroup, a 14 d subgroup and a 21 d subgroup, 12 rats in each subgroup. The chronic mild unpredictable stress stimulus combined with lonely breeding were applied to establish the depression model of rats, which was performed simultaneously with intervention treatment...
February 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29222304/targeting-novel-mechanisms-of-pain-in-sickle-cell-disease
#4
REVIEW
Huy Tran, Mihir Gupta, Kalpna Gupta
Patients with sickle cell disease (SCD) suffer from intense pain that can start during infancy and increase in severity throughout life, leading to hospitalization and poor quality of life. A unique feature of SCD is vaso-occlusive crises (VOCs) characterized by episodic, recurrent, and unpredictable episodes of acute pain. Microvascular obstruction during a VOC leads to impaired oxygen supply to the periphery and ischemia reperfusion injury, inflammation, oxidative stress, and endothelial dysfunction, all of which may perpetuate a noxious microenvironment leading to pain...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29218948/-preliminary-screening-of-biomarkers-for-curcumin-s-antidepressant-effect-based-on-metabonomics-method
#5
Zhi-Jie Ma, Wei Zhang, Jie-Ming Dong, Xiao-Hong Yu, Xiao-Mei Zhao, Shi-Biao Pu
To screen potential biomarkers of curcumin related to treating depression rats by using metabolomics means, so as to explore the antidepressant action mechanism of curcumin. The healthy male SD rats were randomly divided into four groups. Chronic unpredictable mild stress (CUMS) stimulation was conducted for modeling for 2 weeks, and then curcumin (200 mg•kg⁻¹) or venlafaxine (40 mg•kg⁻¹) was given by gavage administration. The blank group and model group rats were given with the same volume of 1% CMCNa normal saline, once per day for two weeks...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29217494/regulation-of-the-kynurenine-metabolism-pathway-by-xiaoyao-san-and-the-underlying-effect-in-the-hippocampus-of-the-depressed-rat
#6
Jiajia Wang, Xiaofang Li, Shugui He, Lijun Hu, Jiewen Guo, Xiangning Huang, Jinqing Hu, Yaoqun Qi, Bin Chen, Dewei Shang, Yuguan Wen
ETHNOPHARMACOLOGICAL RELEVANCE: Xiaoyao San (XYS) is a classic Chinese herbal formula for treatment of depression. The present study aimed to investigate the antidepressant effects of XYS in a rat model of chronic unpredictable mild stress (CUMS) and the underlying mechanisms. MATERIALS AND METHODS: A CUMS rat model of depression was established via 4 weeks of unpredictable stimulation. Then the rats were orally administered paroxetine and XYS for 2 weeks with continued stress...
December 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29215318/therapeutic-potential-of-silymarin-in-chronic-unpredictable-mild-stress-induced-depressive-like-behavior-in-mice
#7
Vishnu N Thakare, Rajesh R Patil, Rajesh J Oswal, Valmik D Dhakane, Manoj K Aswar, Bhoomika M Patel
Silymarin, a plant-derived polyphenolic flavonoid of Silybum marianum, elicited significant antidepressant-like activity in an acute restraint stress model of depression. It improved monoamines, mainly 5-hydroxytryptamine (5-HT) levels in the cortex, dopamine (DA) and norepinephrine (NE) in the cerebellum in mice. The present study was undertaken to explore the antidepressant potential of silymarin in chronic unpredictable mild stress (CUMS) induced depressive-like behavior in mice, and to find out its probable mechanism(s) of action, mainly neurogenesis, neuroinflammation, and/or oxidative stress...
December 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29206699/evaluation-of-antidepressant-activity-of-methanolic-extract-of-saraca-asoca-bark-in-a-chronic-unpredictable-mild-stress-model
#8
Meghna Gill, Manas Kinra, Amita Rai, Mallikarjuna R Chamallamudi, Nitesh Kumar
It is well established that chronic exposure to stressful events plays an important role in the etiology of depression. Saraca asoca (Roxb.), De. wild, or Saraca indica, belonging to family Fabaceae, is endogenous to India. The flowers, seeds, bark, and leaves of the plant have been used widely in Ayurveda medicine. The bark extract of S. asoca has shown chemoprotection, myeloprotection, and antioxidant potential. Owing to the above-mentioned properties of the plant, the present study sought to evaluate the effect of a methanolic extract of S...
December 4, 2017: Neuroreport
https://www.readbyqxmd.com/read/29204911/repeated-shock-stress-facilitates-basolateral-amygdala-synaptic-plasticity-through-decreased-camp-specific-phosphodiesterase-type-iv-pde4-expression
#9
Steve Ryan, Chenchen Li, Aurélie Menigoz, Rimi Hazra, Joanna Dabrowska, David Ehrlich, Katelyn Gordon, Donald G Rainnie
Previous studies have shown that exposure to stressful events can enhance fear memory and anxiety-like behavior as well as increase synaptic plasticity in the rat basolateral amygdala (BLA). We have evidence that repeated unpredictable shock stress (USS) elicits a long-lasting increase in anxiety-like behavior in rats, but the cellular mechanisms mediating this response remain unclear. Evidence from recent morphological studies suggests that alterations in the dendritic arbor or spine density of BLA principal neurons may underlie stress-induced anxiety behavior...
December 4, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29204111/stereological-study-on-the-positive-effect-of-running-exercise-on-the-capillaries-in-the-hippocampus-in-a-depression-model
#10
Linmu Chen, Chunni Zhou, Chuanxue Tan, Feifei Wang, Yuan Gao, Chunxia Huang, Yi Zhang, Lin Jiang, Yong Tang
Running exercise is an effective method to improve depressive symptoms when combined with drugs. However, the underlying mechanisms are not fully clear. Cerebral blood flow perfusion in depressed patients is significantly lower in the hippocampus. Physical activity can achieve cerebrovascular benefits. The purpose of this study was to evaluate the impacts of running exercise on capillaries in the hippocampal CA1 and dentate gyrus (DG) regions. The chronic unpredictable stress (CUS) depression model was used in this study...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29203852/the-dynamics-of-stress-a-longitudinal-mri-study-of-rat-brain-structure-and-connectome
#11
R Magalhães, D A Barrière, A Novais, F Marques, P Marques, J Cerqueira, J C Sousa, A Cachia, F Boumezbeur, M Bottlaender, T M Jay, S Mériaux, N Sousa
Stress is a well-established trigger for a number of neuropsychiatric disorders, as it alters both structure and function of several brain regions and its networks. Herein, we conduct a longitudinal neuroimaging study to assess how a chronic unpredictable stress protocol impacts the structure of the rat brain and its functional connectome in both high and low responders to stress. Our results reveal the changes that stress triggers in the brain, with structural atrophy affecting key regions such as the prelimbic, cingulate, insular and retrosplenial, somatosensory, motor, auditory and perirhinal/entorhinal cortices, the hippocampus, the dorsomedial striatum, nucleus accumbens, the septum, the bed nucleus of the stria terminalis, the thalamus and several brain stem nuclei...
December 5, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29203333/perinatal-fluoxetine-increases-hippocampal-neurogenesis-and-reverses-the-lasting-effects-of-pre-gestational-stress-on-serum-corticosterone-but-not-on-maternal-behavior-in-the-rat-dam
#12
Mary Gemmel, Danny Harmeyer, Eszter Bögi, Marianne Fillet, Lesley A Hill, Geoffrey L Hammond, Thierry D Charlier, Jodi L Pawluski
There is increasing evidence that mental health concerns, stress-related mental illnesses, and parental stress prior to conception have long-term effects on offspring outcomes. However, more work is needed to understand how pre-gestational stress might affect neurobehavioral outcomes in the mother. We investigated how chronic stress prior to gestation affects the maternal behavior and related physiology, and aimed to determine the role that perinatal SSRIs may have in altering these stress effects. To do this, female Sprague-Dawley rats were subject to chronic unpredictable stress (CUS) prior to breeding and during the perinatal period they were administered fluoxetine (10mg/kg/day)...
December 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29203227/behaviour-of-adult-5-ht1a-receptor-knockout-mice-exposed-to-stress-during-prenatal-development
#13
Veronika Kiryanova, Victoria M Smith, Michael C Antle, Richard H Dyck
Chronic maternal stress during pregnancy can have long-term, detrimental consequences for the offspring. An understanding of the mechanisms responsible for mediating these effects is essential for devising therapeutic interventions. Here, we examined whether serotonin 1A receptor (5-HT1AR) mediates the effects of maternal stress on the behavioural outcomes of the offspring as adults. Heterozygous (HET) mouse dams were bred with HET males and were randomly assigned to stress or control groups. Pregnant dams in the stress group were exposed to a regime of chronic unpredictable stress from embryonic day 7 to 18...
December 1, 2017: Neuroscience
https://www.readbyqxmd.com/read/29201187/shuyu-capsules-relieve-liver-qi-depression-by-regulating-erk-creb-bdnf-signal-pathway-in-central-nervous-system-of-rat
#14
Hongyan Wang, Yingquan Zhang, Helou Li, Wei Zeng, Mingqi Qiao
The purpose of this study was to investigate the possible therapeutic mechanism of Shuyu capsules in liver-qi depression. Liver-qi depression rats were prepared based on chronic unpredictable mild stress (CUMS) and delayed constraint. Rats were gavaged with Shuyu capsule, fluoxetine, Radix Bupleuri and Radix Paeoniae Alba to constrct rat models. Body weight test, sucrose preference test and open-field test were applied to test rat models. Western blot analysis and quantitative real-time PCR was applied to determine the relative expression of extracellular signal-regulated protein kinase (ERK), cyclic AMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in hippocampus and frontal lobe tissues...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29196269/diffusion-mri-and-mr-spectroscopy-reveal-microstructural-and-metabolic-brain-alterations-in-chronic-mild-stress-exposed-rats-a-cms-recovery-study
#15
Ahmad Raza Khan, Brian Hansen, Ove Wiborg, Christopher D Kroenke, Sune Nørhøj Jespersen
Chronic mild stress (CMS) induced depression elicits several debilitating symptoms and causes a significant economic burden on society. High variability in the symptomatology of depression poses substantial impediment to accurate diagnosis and therapy outcome. CMS exposure induces significant metabolic and microstructural alterations in the hippocampus (HP), prefrontal cortex (PFC), caudate-putamen (CP) and amygdala (AM), however, recovery from these maladaptive changes are limited and this may provide negative effects on the therapeutic treatment and management of depression...
November 28, 2017: NeuroImage
https://www.readbyqxmd.com/read/29195782/hmgb1-mediates-depressive-behavior-induced-by-chronic-stress-through-activating-the-kynurenine-pathway
#16
Bo Wang, Yong-Jie Lian, Wen-Jun Su, Wei Peng, Xin Dong, Lin-Lin Liu, Hong Gong, Ting Zhang, Chun-Lei Jiang, Yun-Xia Wang
Our previous study has reported that the proactive secretion and role of central high mobility group box 1 (HMGB1) in lipopolysaccharide-induced depressive behavior. Here, the potential mechanism of HMGB1 mediating chronic-stress-induced depression through the kynurenine pathway (KP) was further explored both in vivo and in vitro. Depression model was established with the 4-week chronic unpredictable mild stress (CUMS). Sucrose preference and Barnes maze test were performed to reflect depressive behaviors. The ratio of kynurenine (KYN)/tryptophan (Trp) represented the enzyme activity of indoleamine-2,3-dioxygenase (IDO)...
November 28, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29187376/targeting-novel-mechanisms-of-pain-in-sickle-cell-disease
#17
REVIEW
Huy Tran, Mihir Gupta, Kalpna Gupta
Patients with sickle cell disease (SCD) suffer from intense pain that can start during infancy and increase in severity throughout life, leading to hospitalization and poor quality of life. A unique feature of SCD is vaso-occlusive crises (VOCs) characterized by episodic, recurrent, and unpredictable episodes of acute pain. Microvascular obstruction during a VOC leads to impaired oxygen supply to the periphery and ischemia reperfusion injury, inflammation, oxidative stress, and endothelial dysfunction, all of which may perpetuate a noxious microenvironment leading to pain...
November 30, 2017: Blood
https://www.readbyqxmd.com/read/29187314/what-is-stressful-for-females-differential-effects-of-unpredictable-environmental-or-social-stress-in-cd1-female-mice
#18
Harold Dadomo, Laura Gioiosa, Jenny Cigalotti, Graziano Ceresini, Stefano Parmigiani, Paola Palanza
Stressful life events are a major factor in the etiology of several diseases, such as cardiovascular, inflammatory and psychiatric disorders (i.e., depression and anxiety), with the two sexes greatly differing in vulnerability. In humans and other animals, physiological and behavioral responses to stress are strongly dependent on gender, and conditions that are stressful for males are not necessarily stressful for females. Hence the need of an animal model of social chronic stress specifically designed for females...
November 26, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29185057/implications-of-a-paediatrician-psychologist-tandem-for-sickle-cell-disease-care-and-impact-on-cognitive-functioning
#19
Adrienne Lerner, Hervé Picard, Adrien May, Vincent Gajdos, Louise Malou-Dhaussy, Flaviana Maroja-Cox, Laurence Salomon, Marie-Hélène Odièvre
Sickle cell disease (SCD), a life-threatening chronic disease, necessitates a paediatric treatment plan that considers the influence of psychological, family and intercultural factors. At the Louis-Mourier Hospital (APHP) in Colombes, France, we introduced an original paediatric-psychological partnership where a clinical psychologist accompanies the paediatrician at programmed consultations. We evaluated children and their parents treated in Colombes and in two other paediatric units using standardized culture-free tools and clinical interviews to evaluate the psychological repercussions of SCD...
November 29, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29182615/effects-of-individual-stressors-used-in-a-battery-of-chronic-unpredictable-stress-on-long-term-plasticity-in-the-hippocampus-of-juvenile-rats
#20
Alexandra A Gorbunova, Irina V Kudryashova, Anna O Manolova, Margarita R Novikova, Mikhail Yu Stepanichev, Natalia V Gulyaeva
We have studied alterations in the properties of long-term potentiation (LTP) in hippocampal slices of juvenile rats induced by the exposure of animals to different individual stressors usually used in batteries of chronic unpredictable stress (CUS), a widely used model of depression. Social isolation for 16 h did substantially affect neither the magnitude and nor the development of LTP. The effects of stroboscopic illumination and water deprivation appeared most severe, though opposite: the first stressor had activating effect, whereas the second one inhibited the development of LTP...
2017: Acta Neurobiologiae Experimentalis
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