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https://www.readbyqxmd.com/read/28810562/anti-depressant-like-effects-of-jieyu-chufan-capsules-in-a-mouse-model-of-unpredictable-chronic-mild-stress
#1
Hui Zhao, Bingyu Liang, Linjie Yu, Yun Xu
Jieyu chufan (JYCF) is a well-known Chinese traditional medicine used for depression; however, the molecular mechanism underlying its anti-depressant action has remained elusive. In the present study, the anti-depressant effects of JYCF and the potential mechanisms were investigated in a mouse model. Five groups of 12 C57BL/6 mice each were used in the study, including a normal control group (NC group), a model control group (MC group) and three groups, which received different doses of JYCF (1.25, 2.5 and 5 g/kg) orally for 21 days (JYCF groups)...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28808696/psychological-stress-alters-extracellular-matrix-metabolism-in-mandibular-condylar-cartilage
#2
Qiang Li, Fei Huang, Jia Liu, Yin Hua Zhao, Min Zhang, Yong Jin Chen
OBJECTIVE: To explore the effect of long-term stress on the temporomandibular joint (TMJ) condyle and its possible underlying mechanism. METHODS: A 12-week, chronic unpredictable mild stress (CUMS) model was used to induce long-term psychological stress in rats. Rats were randomly divided into control group (CONT), chronic unpredictable mild stress group (CUMS) and chronic unpredictable mild stress with fluoxetine treatment group (CUMS + DT) (n = 30 per group). A 5 mg/kg dose of fluoxetine was intraperitoneally injected daily 0...
2017: Chinese Journal of Dental Research
https://www.readbyqxmd.com/read/28806788/chronic-unpredictable-stress-exacerbates-surgery-induced-sickness-behavior-and-neuroinflammatory-responses-via-glucocorticoids-secretion-in-adult-rats
#3
Na Wang, Hong Ma, Zhe Li, Yalei Gao, Xuezhao Cao, Yanhua Jiang, Yongjian Zhou, Sidan Liu
METHODS: Sprague-Dawley adult male rats (12-14 weeks old) were exposed to 14-day CUS and then subjected to partial hepatectomy 24 h after the last stress session. The rats were pretreated with an antagonist of the glucocorticoids (GCs) receptor RU486 (30 mg/kg, i.p.) 1 h prior to stress exposure. The behavioral changes were evaluated with open field test and elevated plus-maze test. The hippocampal cytokines interleukin (IL)-1β and IL-6 were measured on postoperative days 1, 3 and 7...
2017: PloS One
https://www.readbyqxmd.com/read/28803118/complex-interactions-between-the-subject-factors-of-biological-sex-and-prior-histories-of-binge-drinking-and-unpredictable-stress-influence-behavioral-sensitivity-to-alcohol-and-alcohol-intake
#4
Sema G Quadir, Eugenie Guzelian, Mason A Palmer, Douglas L Martin, Jennifer Kim, Karen K Szumlinski
Alcohol use disorders, affective disorders and their comorbidity are sexually dimorphic in humans. However, it is difficult to disentangle the interactions between subject factors influencing alcohol sensitivity in studies of humans. Herein, we combined murine models of unpredictable, chronic, mild stress (UCMS) and voluntary binge-drinking to examine for sex differences in the interactions between prior histories of excessive ethanol-drinking and stress upon ethanol-induced changes in motor behavior and subsequent drinking...
August 9, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28800278/the-antidepressant-like-effect-of-ocimum-basilicum-in-an-animal-model-of-depression
#5
S S Ali, M G Abd El Wahab, N N Ayuob, M Suliaman
We investigated the efficacy of Ocimum basilicum (OB) essential oils for treating depression related behavioral, biochemical and histopathological changes caused by exposure to chronic unpredictable mild stress (CUMS) in mice and to explore the mechanism underlying the pathology. Male albino mice were divided into four groups: controls; CUMS; CUMS plus fluoxetine, the antidepressant administered for pharmacological validation of OB; and CUMS plus OB. Behavioral tests included the forced swim test (FST), elevated plus-maze (EPM) and the open field test (OFT); these tests were performed at the end of the experiment...
August 11, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28794421/beta-hydroxybutyrate-an-endogenic-nlrp3-inflammasome-inhibitor-attenuates-stress-induced-behavioral-and-inflammatory-responses
#6
Takehiko Yamanashi, Masaaki Iwata, Naho Kamiya, Kyohei Tsunetomi, Naofumi Kajitani, Nodoka Wada, Takahiro Iitsuka, Takahira Yamauchi, Akihiko Miura, Shenghong Pu, Yukihiko Shirayama, Ken Watanabe, Ronald S Duman, Koichi Kaneko
Neuro-inflammation has been shown to play a critical role in the development of depression. Beta-hydroxybutyrate (BHB) is a ketone body and has recently been reported to exert anti-inflammatory effects via inhibition of NLRP3 inflammasome. Here, we investigated the potential antidepressant and anti-inflammatory effects of BHB on rats exposed to acute and chronic stress. We examined the influence of repeated BHB administration on depressive and anxiety behaviors in a rodent model of chronic unpredictable stress (CUS)...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28790887/mir-16-and-fluoxetine-both-reverse-autophagic-and-apoptotic-change-in-chronic-unpredictable-mild-stress-model-rats
#7
Yang Yang, Zhiying Hu, Xiaoxue Du, Henry Davies, Xue Huo, Marong Fang
In the clinic selective serotonin reuptake inhibitors (SSRIs), like Fluoxetine, remain the primary treatment for major depression. It has been suggested that miR-16 regulates serotonin transporters (SERT) via raphe nuclei and hippocampal responses to antidepressants. However, the underlying mechanism and regulatory pathways are still obtuse. Here, a chronic unpredicted mild stress (CUMS) depression model in rats was established, and then raphe nuclei miR-16 and intragastric Fluoxetine injections were administered for a duration of 3 weeks...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28782622/banxia-houpu-decoction-restores-glucose-intolerance-in-cums-rats-through-improvement-of-insulin-signaling-and-suppression-of-nlrp3-inflammasome-activation-in-liver-and-brain
#8
Ke-Ke Jia, Yan-Jing Zheng, Yan-Xiu Zhang, Jia-Hui Liu, Rui-Qing Jiao, Ying Pan, Ling-Dong Kong
ETHNOPHARMACOLOGICAL RELEVANCE: Banxia-houpu decoction is a famous formula in traditional Chinese medicine (TCM) with the powerful anti-depressant activity. AIM OF THE STUDY: This study aimed to investigate the effect of Banxia-houpu decoction on glucose intolerance associated with anhedonia in chronic unpredictable mild stress (CUMS) rats, then to explore its underlying pharmacological mechanisms. MATERIALS AND METHODS: After 6-week CUMS procedure, male Wistar rats were given Banxia-houpu decoction (3...
August 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28782590/may-the-use-of-different-background-strains-strain-the-stress-related-phenotype-of-gr-mice
#9
Miriam A Vogt, Natascha Pfeiffer, Anne Marie Le Guisquet, Christiane Brandwein, Bruno Brizard, Peter Gass, Catherine Belzung, Sabine Chourbaji
Genetically altered mice are available on different background strains. While respective backcrosses are often performed for pragmatic reasons, e.g. references, comparability, or existing protocols, the interaction between the mutations per se and the background strain often remains a neglected factor. The heterozygous mutation of the glucocorticoid receptor gene (GR) represents a well-examined model for depressive-like behavior in mice. To address the question in how far a robust depressive-like phenotype on a distinct background strain may allow a generalized conclusion, we analyzed respective phenotypes in two commonly used inbred strains: i...
August 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28780280/schisandrin-rescues-depressive-like-behaviors-induced-by-chronic-unpredictable-mild-stress-via-gdnf-erk1-2-ros-and-pi3k-akt-nox-signaling-pathways-in-mice
#10
Shutong Wan, Mengjie Xu, Liwen Hu, Tingxu Yan, Bosai He, Feng Xiao, Kaishun Bi, Ying Jia
The current study aimed to prove the antidepressant-like effects and the probable mechanisms of Schisandrin on depression, which induced by chronic unpredictable mild stress (CUMS) in mice. Four weeks of CUMS exposure resulted in depressive-like behavior, as indicated by the significant decrease in sucrose consumption and increase the immobility time in the forced swim test, but without any influence on the locomotor activity. Further, there were significant downregulations of GDNF/ERK1/2/ROS and PI3K/AKT/NOX signaling pathways in the hippocampus and prefrontal cortex in depressed mice...
August 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28765907/antidepressant-like-effects-of-marasmius%C3%A2-androsaceus-metabolic-exopolysaccharides-on-chronic-unpredictable-mild-stress-induced-rat-model
#11
Jia Song, Xue Wang, Yu Huang, Yidi Qu, Lesheng Teng, Di Wang, Zhaoli Meng
Marasmius androsaceus (M. androsaceus), a medicinal fungus, has various pharmacological activities including antidepression. The present study investigated the effects of exopolysaccharides obtained during M. androsaceus submerged fermentation in a chronic unpredictable mild stress (CUMS)‑induced depression rat model. Similar to fluoxetine (positive drug), 4‑week administration of M. androsaceus exopolysaccharides (MEPS) at doses of 6, 30 and 150 mg/kg strongly enhanced bodyweight gain and sucrose consumption, and reduced the immobility time in forced swimming test and tail suspension test in CUMS rats...
August 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28761074/antidepressant-like-effects-and-cognitive-enhancement-of-schisandra-chinensis-in-chronic-unpredictable-mild-stress-mice-and-its-related-mechanism
#12
Tingxu Yan, Bosai He, Shutong Wan, Mengjie Xu, Huilin Yang, Feng Xiao, Kaishun Bi, Ying Jia
The aim of this study was to evaluate whether Schisandra chinensis extract (SCE) administration influences chronic unpredictable mild stress (CUMS)-induced depression and cognitive impairment, and explores underlying mechanisms. Sucrose preference test (SPT) and forced swimming test (FST) were used for assessing depressive symptoms, and Y-maze, Morris water maze were used for evaluating cognition processes. The results showed that CUMS (4 weeks) was effective in producing both depression and memory deficits in mice...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28758176/antidepressant-like-effect-of-bacopaside-i-in-mice-exposed-to-chronic-unpredictable-mild-stress-by-modulating-the-hypothalamic-pituitary-adrenal-axis-function-and-activating-bdnf-signaling-pathway
#13
Xianpeng Zu, Mingjian Zhang, Wencai Li, Haisheng Xie, Zhang Lin, Niao Yang, Xinru Liu, Weidong Zhang
Preliminary studies conducted in our laboratory have confirmed that Bacopaside I (BS-I), a saponin compound isolated from Bacopa monnieri, displayed antidepressant-like activity in the mouse behavioral despair model. The present investigation aimed to verify the antidepressant-like action of BS-I using a mouse model of behavioral deficits induced by chronic unpredictable mild stress (CUMS) and further probe its underlying mechanism of action. Mice were exposed to CUMS for a period of 5 consecutive weeks to induce depression-like behavior...
July 31, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28755980/profiling-coping-strategies-in-male-and-female-rats-potential-neurobehavioral-markers-of-increased-resilience-to-depressive-symptoms
#14
Molly Kent, Massimo Bardi, Ashley Hazelgrove, Kaitlyn Sewell, Emily Kirk, Brooke Thompson, Kristen Trexler, Brennan Terhune-Cotter, Kelly Lambert
Coping strategies have been associated with differential stress responsivity, perhaps providing a valuable neurobiological marker for susceptibility to the emergence of depressogenic symptoms or vulnerability to other anxiety-related disorders. Rats profiled with a flexible coping phenotype, for example, exhibit increased neurobiological markers of emotional regulation compared to active and passive copers (Bardi et al., 2012; Lambert et al., 2014). In the current study, responses of male and female rats to prediction errors in a spatial foraging task (dry land maze; DLM) were examined after animals were exposed to chronic unpredictable stress (CUS)...
August 3, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28752967/-expression-of-hsp70-in-kunming-mouse-embryos-stimulated-by-chronic-mild-anticipatory-stress
#15
Xiao-Hong Li, Shan Luo, Wei Fan, Xun Zeng, Yu Bai, Lang Qin, Shang-Wei Li
OBJECTIVE: To measure the expression of heat shock protein 70 (HSP70) in mice embryos with the stimulation of chronic mild anticipatory stress (CUMS) to female Kunming mice. METHODS: Three hundreds female Kunming mice were stressed by 9 chronic mild unpredictable stress factors for 28 days and then divided into three groups of mild, moderate and severe stress. PMSG/hCG was measured to assess the induction of superovulation, and ovarian response and embryo development potential were observed...
July 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28740098/puerarin-ameliorated-the-behavioral-deficits-induced-by-chronic-stress-in-rats
#16
Zhi-Kun Qiu, Guan-Hua Zhang, De-Sheng Zhong, Jia-Li He, Xu Liu, Ji-Sheng Chen, Da-Nian Wei
The present study aimed to investigate the mechanisms underlying the antidepressant-like effects of puerarin via the chronic unpredictable stress (CUS) procedure in rats. Similar to Sertraline (Ser), Chronic treatment of puerarin (60 and 120 mg/kg, i.g) elicited the antidepressant-like effects by reversing the decreased sucrose preference in sucrose preference test (SPT), by blocking the increased latency to feed in novelty-suppressed feeding test (NSFT) and the increased immobility time in forced swimming test (FST) without affecting locomotor activity...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28735061/up-regulation-of-glur1-in-paraventricular-nucleus-and-greater-expressions-of-synapse-related-proteins-in-the-hypothalamus-of-chronic-unpredictable-stress-induced-depressive-rats
#17
Rong Li, Xia Zhao, Li Cai, Wan-Wan Gao
Converging evidence indicates that abnormal glutamatergic and synaptic systems may be associated with the pathophysiology of depression. Over-activation of corticotropin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) plays a key role in the hypothalamic-pituitary-adrenal (HPA) axis hyperactivity and is a prominent feature in depression. In this study, we examined the effect of chronic unpredictable stress (CUS) in rats on the expression of AMPA subunit GluR1 protein in the hypothalamic PVN as well as on the expression of GluR1 and several synapse-related proteins in the hypothalamus...
July 19, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28732760/rutin-alleviates-chronic-unpredictable-stress-induced-behavioral-alterations-and-hippocampal-damage-in-mice
#18
Arun Parashar, Vineet Mehta, Malairaman Udayabanu
Chronic stress results in neurological complications like depression, cognitive dysfunction, and anxiety disorders. In our previous study, we observed that Urtica dioica leaf extract attenuated chronic stress-induced complications. Further, we observed that Urtica dioica contained a great amount of the flavonoid rutin in it. Hence, we aimed to evaluate the effect of rutin on 21days chronic unpredictable stress (CUS) mouse model. CUS led to a decline in locomotion & muscle coordination abilities, cognitive deficits, anxiety, and depression...
July 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28704798/experimental-studies-on-possible-regulatory-role-of-nitric-oxide-on-the-differential-effects-of-chronic-predictable-and-unpredictable-stress-on-adaptive-immune-responses
#19
Tarun Thakur, Kavita Gulati, Nishant Rai, Arunabha Ray
The present study was designed to investigate the effects of chronic predictable stress (CPS) and chronic unpredictable stress (CUS) on immunological responses in KLH-sensitized rats and involvement of NOergic signaling pathways mediating such responses. Male Wistar rats (200-250g) were exposed to either CPS or CUS for 14days and IgG antibody levels and delayed type hypersensitivity (DTH) response was determined to assess changes in adaptive immunity. To evaluate the role of nitric oxide during such immunomodulation, biochemical estimation of stable metabolite of nitric oxide (NOx) and 3-nitrotyrosine (3-NT, a marker of peroxynitrite formation) were done in both blood and brain...
July 10, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28704473/enriched-environment-and-stress-exposure-influence-splenic-b-lymphocyte-composition
#20
Blake T Gurfein, Burcu Hasdemir, Jeffrey M Milush, Chadi Touma, Rupert Palme, Douglas F Nixon, Nicholas Darcel, Frederick M Hecht, Aditi Bhargava
Prolonged chronic stress has deleterious effects on immune function and is associated with numerous negative health outcomes. The spleen harbors one-fourth of the body's lymphocytes and mediates both innate and adaptive immune responses. However, the subset of splenic lymphocytes that respond, either adaptively or maladaptively, to various stressors remains largely unknown. Here we investigated the effects of unpredictable chronic mild stress (CMS) exposure on spleen composition in male mice housed in two different caging conditions: standard caging (Cntl) and enriched environment (EE)...
2017: PloS One
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