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https://www.readbyqxmd.com/read/28213267/ferulic-acid-inhibits-neuro-inflammation-in-mice-exposed-to-chronic-unpredictable-mild-stress
#1
Ya-Min Liu, Ji-Duo Shen, Li-Ping Xu, Han-Bing Li, Yu-Cheng Li, Li-Tao Yi
Ferulic acid is a hydroxycinnamic acid that widely presents in plant cell wall components. It has been demonstrated that ferulic acid can attenuate depressive-like behaviors in both forced swimming test and tail suspension test. Considering that depression is an inflammatory related mental disease, our present study was aimed to investigate the role of ferulic acid in the regulation of microglia activation, pro-inflammatory cytokines, nuclear factor kappa B (NF-κB) and nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in mice exposed to chronic unpredictable mild stress (CUMS)...
February 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28158955/rapid-antidepressant-effect-of-hydrogen-sulfide-evidence-for-activation-of-mtorc1-trkb-ampa-receptor-pathways
#2
Xiao-Yi Hou, Zhuang-Li Hu, Deng-Zheng Zhang, Wei Lu, Jun Zhou, Pei-Fei Wu, Xin-Lei Guan, Qian-Qian Han, Si-Long Deng, Hai Zhang, Jian-Guo Chen, Fang Wang
AIMS: We asked whether Hydrogen sulfide (H2S), as the third gaseous mediator, provided fast antidepressant effect on major depressive disorders and the underlying mechanisms. RESULTS: The decreased level of H2S was detected in the hippocampus of chronic unpredictable mild stress (CUMS)-treated rats. Acute administration of H2S either by H2S inhalation or by the donor NaHS produced a rapid antidepressant-like behavioral effect. Further investigation demonstrated that this effect of H2S was mediated by reversing the CUMS-induced decrease in dendritic spine density and required the activation of mTORC1 and neurotrophic TrkB receptors, proceeded to increase synaptic protein expression including PSD95, synaptophysin, and AMPA receptor GluR1/2 subunit...
February 3, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28147225/electroacupuncture-relieves-depression-like-symptoms-in-rats-exposed-to-chronic-unpredictable-mild-stress-by-activating-erk-signaling-pathway
#3
Weidong Li, Yan Zhu, Shakir M Saud, Qiujun Guo, Shengyan Xi, Baohui Jia, Shuang Jiao, Xiuyan Yang, Jun Lu, Sihong Song, Ya Tu
Electroacupuncture (EA) has been shown to alleviate the symptoms associated with major depressive disorder; however, the underlying mechanisms remain unclear. While the mainstay treatment for depression are pharmacological agents that modulate serotonergic and/or noradrenergic activity of the brain, recent data suggest that, neurotrophins may play a larger role in the pathogenesis of depression and may offer better therapeutic potential in alleviating symptoms associated with depression. One downstream target of neurotrophins is the extracellular signal-regulated kinase (ERK)/Mitogen-activated protein kinase (MAPK) cascade, a major mediator of cellular stress often associated with clinical depression...
January 29, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28131625/deficits-in-cognitive-flexibility-induced-by-chronic-unpredictable-stress-are-associated-with-impaired-glutamate-neurotransmission-in-the-rat-medial-prefrontal-cortex
#4
Julianne D Jett, Sarah E Bulin, Lauren C Hatherall, Carlie M McCartney, David A Morilak
Deficits in cognitive flexibility, the ability to modify behavior in response to changes in the environment, contribute to the onset and maintenance of stress-related neuropsychiatric illnesses, such as depression. Cognitive flexibility depends on medial prefrontal cortex (mPFC) function, and in depressed patients, cognitive inflexibility is associated with hypoactivity and decreased glutamate receptor expression in the mPFC. Rats exposed to chronic unpredictable stress (CUS) exhibit compromised mPFC function on the extradimensional (ED) set-shifting task of the attentional set-shifting test...
January 26, 2017: Neuroscience
https://www.readbyqxmd.com/read/28130175/up-regulation-of-sirt6-in-the-hippocampus-induced-rats-with-depression-like-behavior-via-the-block-akt-gsk3%C3%AE-signaling-pathway
#5
Qiang Mao, Xue Gong, Chanjuan Zhou, Zhe Tu, Libo Zhao, Ling Wang, Xinfa Wang, Lu Sun, Jinjun Xia, Bin Lian, Jianjun Chen, Jun Mu, Deyu Yang, Peng Xie
Major depression is the leading cause of disability worldwide, which is associated with diverse alterations in brain such as neuro-inflammation, synaptic dysfunction, and cognitive deficit. Accumulating evidences suggest sirtuins (SIRTs) are involved in brain developmental disorders, metabolic diseases and play a key role in cognition and synaptic plasticity, yet the role in mood regulation remains controversial. Hence, Western blotting and RT-qPCR were used to investigate whether SIRTs (SIRT1-7) expression levels were altered in the hippocampus of rats, which followed 5 weeks of chronic unpredictable mild stress (CUMS) treatment, the results showed depressive-like behaviors: like body weight, forced swim test and sucrose preference test and SIRT6 was a significant increase in the hippocampal of CUMS rats...
January 24, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28128787/an-invisible-student-population-accommodating-and-serving-college-students-with-lupus
#6
Neelam Agarwal, Vinod Kumar
BACKGROUND: Systemic Lupus Erythematosus (SLE), or lupus, is a chronic autoimmune disorder. Individuals with lupus face unique psychosocial and emotional challenges such as living with the unpredictability of the disease, symptoms such as fatigue, pain and depression, anxiety, cognitive problems, and coping with stress. OBJECTIVE: This article will attempt to shed light on the role that lupus plays in the lives of college students in their academics and other unique psychosocial needs...
January 23, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28126450/piper-sarmentosum-roxb-produces-antidepressant-like-effects-in-rodents-associated-with-activation-of-the-creb-bdnf-erk-signalling-pathway-and-reversal-of-hpa-axis-hyperactivity
#7
Qing Li, Fa-Lin Qu, Yue Gao, Yi-Ping Jiang, Khalid Rahman, Kuo-Hsiung Lee, Ting Han, Lu-Ping Qin
ETHNOPHARMACOLOGICAL RELEVANCE: There are many plants of genus Piper which have been reported to induce antidepressant-like effects, Piper sarmentosum (PS) is one of them. PS is a Chinese herbal medicine and a traditional edible vegetable. MATERIALS AND METHODS: In the present study, the antidepressant-like effects of PS extracts and the ethyl acetate fraction of PS extracts (PSY) were assessed using the open field test (OFT), forced swimming test (FST), and tail suspension test (TST) in mice...
January 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28124522/female-urinary-incontinence-and-sexuality
#8
Renato Lains Mota
Urinary incontinence is a common problem among women and it is estimated that between 15 and 55% of them complain of lower urinary symptoms. The most prevalent form of urinary incontinence is associated with stress, followed by mixed urinary incontinence and urge urinary incontinence. It is a symptom with several effects on quality of life of women mainly in their social, familiar and sexual domains. Female reproductive and urinary systems share anatomical structures, which promotes that urinary problems interfere with sexual function in females...
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28118829/effect-of-xingpijieyu-decoction-on-spatial-learning-and-memory-and-camp-pka-creb-bdnf-pathway-in-rat-model-of-depression-through-chronic-unpredictable-stress
#9
Chunye Wang, Jianyou Guo, Rongjuan Guo
BACKGROUND: Depression is a mental disorder characterized by a pervasive low mood and loss of pleasure or interest in usual activities, and often results in cognitive dysfunction. The disturbance of cognitive processes associated with depression, especially the impairment of learning and memory, exacerbates illness and increases recurrence of depression. XingPiJieYu (XPJY) is one of the most widely clinical formulas of traditional Chinese medicine (TCM) and can improve the symptoms of depression, including learning and memory...
January 24, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28118485/white-matter-atrophy-and-myelinated-fiber-disruption-in-a-rat-model-of-depression
#10
Yuan Gao, Jing Ma, Jing Tang, Xin Liang, Chun-Xia Huang, San-Rong Wang, Lin-Mu Chen, Fei-Fei Wang, Chuan-Xue Tan, Feng-Lei Chao, Lei Zhang, Xuan Qiu, Yan-Min Luo, Qian Xiao, Lian Du, Qian Xiao, Yong Tang
Brain imaging and postmortem studies have indicated that white matter abnormalities may contribute to the pathology and pathogenesis of depression. However, until now, no study has quantitatively investigated white matter changes in depression in rats. The current study used the chronic unpredictable stress (CUS) model of depression. Body weight and sucrose preference test (SPT) scores were assessed weekly. Upon successfully establishing the CUS animal model, all animals were tested using the SPT and the open field test (OFT)...
January 24, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28109109/-role-of-camp-creb-bdnf-signaling-pathway-in-anti-depressive-effect-of-vortioxetine-in-mice
#11
Hui Yu, Jia-Jia Chen, Bing-Qing Zeng, Qiu-Ping Zhong, Jiang-Ping Xu, Yong-Gang Liu
OBJECTIVE: To investigate the effects of vortioxetine on cAMP/CREB/BDNF signal pathway. METHODS: Forty Kunming mice were randomized into control group and chronic unpredictable mild stress (CUMS) group. After establishment of depressive models verified by sucrose preference test, the mice in CUMS group were divided into model group, fluoxetine group and vortioxetine group. The antidepressive effect of vortioxetine was analyzed by tail suspension test, forced swim test and open field test...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28097679/abnormal-levels-of-seven-amino-neurotransmitters-in-depression-rat-brain-and-determination-by-hplc-fld
#12
Ting Cui, Hong-Mei Qiu, Dan Huang, Qi-Xin Zhou, Xiao-Yan Fu, Hai-Yan Li, Xin-Hui Jiang
The determination of amino acids with the actions-like neurotransmitters or modulators have been increasingly important for diagnose in many neuropsychiatric diseases. A rapid and simple high performance liquid chromatography with fluorescence detection (HPLC-FLD) was developed for simultaneous determination of seven amino acids: aspartate (Asp), glutamate (Glu), serine (Ser), glutamine (Gln), glycine (Gly), taurine (Tau) and γ-aminobutyric acid (GABA). Homoserine (Hse) was used as an internal standard (IS)...
January 18, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28096878/reversion-of-bdnf-akt-and-creb-in-hippocampus-of-chronic-unpredictable-stress-induced-rats-effects-of-phytochemical-bacopa-monnieri
#13
Somoday Hazra, Sourav Kumar, Goutam Kumar Saha, Amal Chandra Mondal
OBJECTIVE: The aims of the present study were to explore the behavioural effects and to understand the possible mode of action of Bacopa monnieri extract (BME) on chronic unpredictable stress (CUS) induced depressive model and the biochemical alterations such as brain derived neurotrophic factor (BDNF), Akt, cyclic-AMP response element binding (CREB) protein level in the hippocampus of rats. METHODS: We examined the effects of chronic administration of BME on CUS exposed rats for 28 days...
January 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28094283/adolescent-chronic-unpredictable-stress-exposure-is-a-sensitive-window-for-long-term-changes-in-adult-behavior-in-mice
#14
Nicole L Yohn, Julie A Blendy
Adolescence is a time period in development when the brain undergoes substantial remodeling in response to the environment. To determine whether a stressful experience during adolescence affects adult behavior, we exposed adolescent male and female C57BL/6J mice to chronic unpredictable stress (CUS) for 12 days starting at postnatal day 28 (PND28). We also exposed adult male and female mice to CUS for 12 days beginning at PND70 to determine whether adolescence is a sensitive time period when stress can have long-lasting effects on behavior...
February 1, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28093255/nlrp3-gene-knockout-blocks-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathway-in-cums-induced-depression-mouse-model
#15
Wen-Jun Su, Yi Zhang, Ying Chen, Hong Gong, Yong-Jie Lian, Wei Peng, Yun-Zi Liu, Yun-Xia Wang, Zi-Li You, Shi-Jie Feng, Ying Zong, Guo-Cai Lu, Chun-Lei Jiang
BACKGROUND: Abundant researches indicate that neuroinflammation has important roles in the pathophysiology of depression. Our previous study found that the NLRP3 inflammasome mediated stress-induced depression-like behavior in mice via regulating neuroinflammation. However, it still remains unclear that how the NLRP3 inflammasome influences related inflammatory signaling pathway to contribute to neuroinflammation in depression. METHODS: We used wild-type mice and NLRP3 gene knockout mice to explore the role of NLRP3 inflammasome and related inflammatory signaling pathways in chronic unpredictable mild stress (CUMS) induced depression mouse model...
January 16, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28069457/quercetin-prevents-chronic-unpredictable-stress-induced-behavioral-dysfunction-in-mice-by-alleviating-hippocampal-oxidative-and-inflammatory-stress
#16
Vineet Mehta, Arun Parashar, Malairaman Udayabanu
It is now evident that chronic stress is associated with anxiety, depression and cognitive dysfunction and very few studies have focused on identifying possible methods to prevent these stress-induced disorders. Previously, we identified abundance of quercetin in Urtica dioica extract, which efficiently attenuated stress related complications. Therefore, current study was designed to investigate the effect of quercetin on chronic unpredicted stress (CUS) induced behavioral dysfunction, oxidative stress and neuroinflammation in the mouse hippocampus...
January 7, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28065844/effects-of-the-chronic-restraint-stress-induced-depression-on-reward-related-learning-in-rats
#17
Pan Xu, Kezhu Wang, Cong Lu, Liming Dong, Yixi Chen, Qiong Wang, Zhe Shi, Yanyan Yang, Shanguang Chen, Xinmin Liu
Chronic mild or unpredictability stress produces a persistent depressive-like state. The main symptoms of depression include weight loss, despair, anhedonia, diminished motivation and mild cognition impairment, which could influence the ability of reward-related learning. In the present study, we aimed to evaluate the effects of chronic restraint stress on the performance of reward-related learning of rats. We used the exposure of repeated restraint stress (6h/day, for 28days) to induce depression-like behavior in rats...
March 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28064424/gender-related-hippocampal-proteomics-study-from-young-rats-after-chronic-unpredicted-mild-stress-exposure
#18
Lin-Na Ning, Teng Zhang, Jiang Chu, Na Qu, Li Lin, Ying-Yan Fang, Yan Shi, Peng Zeng, Er-Li Cai, Xiao-Ming Wang, Qun Wang, You-Ming Lu, Xin-Wen Zhou, Qi Zhang, Qing Tian
Clinical data have shown women are more susceptible to depression. This study was performed to identify differentially regulated proteins from hippocampus in chronic unpredicted mild stress (CUMS)-exposed male and female young rats. After 7 weeks of CUMS, depressed male (M-D) and female rats (F-D) and unstressed male (M-C) and female controls (F-C) were studied. By proteomics analysis, 74 differential proteins in F-C/M-C, 79 in F-D/M-D, 77 in F-D/F-C, and 32 in M-D/M-C were found. Further, the synapse-related proteins, cytoskeleton protein tau, and stress-related kinases in hippocampus were assayed by Western blotting...
January 7, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28043834/sub-anesthetic-doses-of-ketamine-exert-antidepressant-like-effects-and-upregulate-the-expression-of-glutamate-transporters-in-the-hippocampus-of-rats
#19
Xianlin Zhu, Gang Ye, Zaiping Wang, Jie Luo, Xuechao Hao
Clinical studies on the role of the glutamatergic system in the pathogenesis of depression found that ketamine induces an antidepressant response, but the molecular mechanisms remain unclear. The present study investigated the effects of sub-anesthetic doses of ketamine on the glutamate reuptake function in the rat hippocampus. Chronic unpredictable mild stress (CUMS) was applied to construct animal models of depression. Sixty adult male Sprague-Dawley rats were randomly assigned to 5 groups and received a different regimen of CUMS and ketamine (10, 25, and 50mg/kg) treatment...
February 3, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28039073/gender-differences-in-aggression-and-cortisol-levels-in-zebrafish-subjected-to-unpredictable-chronic-stress
#20
Cassiano L Rambo, Ricieri Mocelin, Matheus Marcon, Débora Villanova, Gessi Koakoski, Murilo S de Abreu, Thiago A Oliveira, Leonardo J G Barcellos, Angelo L Piato, Carla D Bonan
Chronic stress may cause physical, behavioral and neuropsychiatric changes, affecting the health condition of an individual. Aggression is a universal behavior with great relevance on human and animal social systems. Despite studies showing the influence of chronic stress on aggression, the effects of unpredictable chronic stress (UCS) on aggressive behavior in male and female zebrafish remain unknown. Thus, the aim of this study was to evaluate the effects of UCS on the aggressive behavior and cortisol levels in adult zebrafish of both sexes...
December 28, 2016: Physiology & Behavior
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