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chronic unpredictable stress

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https://www.readbyqxmd.com/read/29454288/apocynum-venetum-leaf-extract-reverses-depressive-like-behaviors-in-chronically-stressed-rats-by-inhibiting-oxidative-stress-and-apoptosis
#1
Xiangting Li, Ting Wu, Zhonghai Yu, Tingting Li, Jingsi Zhang, Zhennian Zhang, Min Cai, Wen Zhang, Jun Xiang, Dingfang Cai
BACKGROUND: Major depressive disorder (MDD) is a common but serious psychiatric disorder, but current treatments are inadequate for approximately half of the patients with MDD. Thus, better methods of treatment are urgently needed. This study aimed to investigate the antidepressant-like effects and potential mechanism of Apocynum venetum leaf extract (AVLE) in chronic unpredictable mild stress (CUMS) rat model of depression. MATERIALS AND METHODS: The CUMS rat model of depression was used to investigate the antidepressant-like activity and relevant mechanism of AVLE (30, 60, and 125 mg/kg, i...
February 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29451821/protection-from-vascular-dysfunction-in-female-rats-with-chronic-stress-and-depressive-symptoms
#2
Steven D Brooks, Stan Hileman, Paul D Chantler, Samantha Milde, Kent C Lemaster, Stephanie Frisbee, J Kevin Shoemaker, Dwayne N Jackson, Jefferson C Frisbee
The increasing prevalence and severity of clinical depression is strongly correlated with vascular disease risk, creating a comorbid condition with poor outcomes, although demonstrating a sexual disparity where females are at lower risk than males for subsequent cardiovascular events. To determine potential mechanisms responsible for this protection against stress/depression-induced vasculopathy in females, we exposed male and female ({plus minus}ovariectomy) rats to the unpredictable chronic mild stress (UCMS) model for 8 weeks and determined depressive symptom severity, vascular reactivity in aortic rings (AR) and ex vivo middle cerebral arteries (MCA), and determined the profile of major metabolites regulating vascular tone...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29451819/protection-from-chronic-stress-and-depressive-symptom-induced-vascular-endothelial-dysfunction-in-female-rats-is-abolished-by-pre-existing-metabolic-disease
#3
Steven D Brooks, Stan Hileman, Paul D Chantler, Samantha Milde, Kent C Lemaster, Stephanie Frisbee, J Kevin Shoemaker, Dwayne N Jackson, Jefferson C Frisbee
While it is known that chronic stress and clinical depression are powerful predictors of poor cardiovascular outcomes, recent clinical evidence has identified correlations between the development of metabolic disease and that for depressive symptoms; creating a combined condition of severely elevated cardiovascular disease risk. In this companion manuscript, we determine the impact of pre-existing metabolic disease on the relationship between chronic stress//depressive symptoms and vascular function, using the obese Zucker (OZR) and the unpredictable chronic mild stress UCMS models...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29438801/specific-activity-features-in-the-forced-swim-test-brain-neurotrophins-and-development-of-stress-induced-depressive-like-behavior-in-rats
#4
Mikhail Stepanichev, Anna Manolova, Danil Peregud, Mikhail Onufriev, Sofia Freiman, Viktor Aniol, Yulia Moiseeva, Margarita Novikova, Natalia Lazareva, Natalia Gulyaeva
Selective vulnerability or resilience to mood disorders is related to individual differences or personality. In the present study forced swim test (FST) was used as a tool for division of male rats according to their immobility behavior. The animals were subjected to a chronic unpredictable mild stress (CUS). Depressive-like behavior and modifications in brain neurotrophin system of were examined after CUS exposure. The low immobile (LI) and high immobile (HI) rats demonstrated elusive differences in expression of BDNF ExVI mRNA and TrkA mRNA which was higher in hippocampus and frontal cortex, respectively, of HI rats as compared to LI animals...
February 10, 2018: Neuroscience
https://www.readbyqxmd.com/read/29436736/psychological-stress-induced-cerebrovascular-dysfunction-the-role-of-metabolic-syndrome-and-exercise
#5
Steven Brooks, Kayla Branyan, Evan DeVallance, Roy Skinner, Kent Lemaster, J Whitney Sheets, Christopher R Pitzer, Shinichi Asano, Randall Bryner, I Mark Olfert, Jefferson C Frisbee, Paul D Chantler
Chronic unresolvable stress leads to the development of depression and cardiovascular disease (CVD). There is a high prevalence of depression with the metabolic syndrome (MetS), however, to what extent the MetS concurrent with psychological stress affects cerebrovascular function is unknown. We investigated the differential effect of MetS on cerebrovascular structure/function in rats (16-17-wk-old) following 8 wk of unpredictable chronic mild stress (UCMS), and whether exercise training could limit any cerebrovascular dysfunction...
February 13, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29434743/anti-depressant-like-effect-of-atractylenolide-i-in-a-mouse-model-of-depression-induced-by-chronic-unpredictable-mild-stress
#6
Haiyan Gao, Xianghua Zhu, Yang Xi, Qun Li, Zhenzhong Shen, Yongjie Yang
Atractylenolide I (AT-I), a major component of the rhizoma of Atractylodes macrocephala Koidz., exerts a wide range of activities. The purpose of the present study was to investigate the anti-depressant-like effect of AT-I in a mouse model of chronic unpredictable mild stress (CUMS), and to explore the possible molecular mechanism involved. It was revealed that AT-I significantly ameliorated CUMS-induced depressive-like behaviors, as evidenced by increased sucrose preference as well as shortened immobility time in the forced swimming and the tail suspension test...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29429380/cardiovascular-and-metabolic-consequences-of-the-association-between-chronic-stress-and-high-fat-diet-in-rats
#7
Bruna B Simas, Everson A Nunes, Carlos C Crestani, Guilherme F Speretta
Obesity and chronic stress are considered independent risk factors for the development of cardiovascular diseases and changes in autonomic system activity. However, the cardiovascular consequences induced by the association between high-fat diet (HFD) and chronic stress are not fully understood. We hypothesized that the association between HFD and exposure to a chronic variable stress (CVS) protocol for four weeks might exacerbate the cardiovascular and metabolic disturbances in rats when compared to these factors singly...
February 10, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29421158/behavioral-and-structural-adaptations-to-stress
#8
REVIEW
Heather A Cameron, Timothy J Schoenfeld
Unpredictable aversive experiences, or stressors, lead to changes in depression- and anxiety-related behavior and to changes in hippocampal structure including decreases in adult neurogenesis, granule cell and pyramidal cell dendritic morphology, and volume. Here we review the relationship between these behavioral and structural changes and discuss the possibility that these changes may be largely adaptive. Specifically, we suggest that new neurons in the dentate gyrus enhance behavioral adaptability to changes in the environment, biasing behavior in novel situations based on previous experience with stress...
February 5, 2018: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/29409919/sst2-receptor-gene-deletion-exacerbates-chronic-stress-induced-deficits-consequences-for-emotional-and-cognitive-ageing
#9
Thomas Damien Prévôt, Cécile Viollet, Jacques Epelbaum, Gaëlle Dominguez, Daniel Béracochéa, Jean-Louis Guillou
This study investigated whether sst2 gene deletion interacts with age and chronic stress exposure to produce exacerbated emotional and cognitive ageing. Middle-aged (10-12 month) sst2 knockout (sst2KO) and wild-type (WT) mice underwent an unpredictable chronic mild stress (UCMS) procedure for 6 weeks or no stress for control groups. This was followed by a battery of tests to assess emotional and cognitive functions and neuroendocrine status (CORT level). A re-evaluation was performed 6 months later (i...
January 31, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29390057/enhanced-hypothalamic-nmda-receptor-activity-contributes-to-hyperactivity-of-hpa-axis-in-chronic-stress-in-male-rats
#10
Jing-Jing Zhou, Yonggang Gao, Xiangjian Zhang, Therese A Kosten, De-Pei Li
Chronic stress stimulates corticotrophin-releasing hormone (CRH)-expressing neurons in the paraventricular nucleus (PVN) of the hypothalamus and leads to hypothalamus-pituitary-adrenal (HPA) axis hyperactivity, but the mechanisms underlying this action are unknown. Because chronic stress enhances N-methyl-D-aspartate receptor (NMDAR) activity in various brain regions, we hypothesized that augmented NMDAR activity contributes to the hyperactivity of PVN-CRH neurons and the HPA axis in chronic stress. We performed whole-cell patch-clamp recordings on PVN-CRH neurons expressing CRH promoter-driven enhanced green fluorescent protein in brain slices from rats exposed to chronic unpredictable mild stress (CUMS) and unstressed rats...
January 30, 2018: Endocrinology
https://www.readbyqxmd.com/read/29385813/the-role-of-musk-in-relieving-the-neurodegenerative-changes-induced-after-exposure-to-chronic-stress
#11
Manal Galal Abd El Wahab, Soad Shaker Ali, Nasra Naeim Ayuob
OBJECTIVE: This study aimed to evaluate the effect induced by musk on Alzheimer's disease-such as neurodegenerative changes in mice exposed to chronic unpredictable mild stress (CUMS). MATERIAL AND METHODS: Forty male Swiss albino mice were divided into 4 groups (n = 10); control, CUMS, CUMS + fluoxetine, CUMS + musk. At the end of the experiment, behavior of the mice was assessed. Serum corticosterone level, hippocampal protein level of the glucocorticoid receptors, and brain-derived neurotropic factor were also assessed...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29382932/improvement-of-penile-neurogenic-and-endothelial-relaxant-responses-by-chronic-administration-of-resveratrol-in-rabbits-exposed-to-unpredictable-chronic-mild-stress
#12
Yusufhan Yazir, Tijen Utkan, Tuğçe Demirtaş Şahin, Semil Selcen Gocmez
Chronic stress is an important public health problem known as a risk factor for depression, cognitive deficits, and also erectile dysfunction (ED). Resveratrol, a plant polyphenol, was reported to activate constitutive endothelial nitric oxide synthase (eNOS). Although resveratrol has been proven to exert beneficial effects on the unpredictable chronic mild stress (UCMS)-induced decline in cognitive functions, its potential protecting effect on the penile tissue subjected to UCMS was in fact not investigated...
January 30, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29382834/metabolite-identification-in-fecal-microbiota-transplantation-mouse-livers-and-combined-proteomics-with-chronic-unpredictive-mild-stress-mouse-livers
#13
Bo Li, Kenan Guo, Li Zeng, Benhua Zeng, Ran Huo, Yuanyuan Luo, Haiyang Wang, Meixue Dong, Peng Zheng, Chanjuan Zhou, Jianjun Chen, Yiyun Liu, Zhao Liu, Liang Fang, Hong Wei, Peng Xie
Major depressive disorder (MDD) is a common mood disorder. Gut microbiota may be involved in the pathogenesis of depression via the microbe-gut-brain axis. Liver is vulnerable to exposure of bacterial products translocated from the gut via the portal vein and may be involved in the axis. In this study, germ-free mice underwent fecal microbiota transplantation from MDD patients and healthy controls. Behavioral tests verified the depression model. Metabolomics using gas chromatography-mass spectrometry, nuclear magnetic resonance, and liquid chromatography-mass spectrometry determined the influence of microbes on liver metabolism...
January 31, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29379286/the-depressive-like-behaviors-of-chronic-unpredictable-mild-stress-treated-mice-ameliorated-by-tibetan-medicine-zuotai-involvement-in-the-hypothalamic-pituitary-adrenal-hpa-axis-pathway
#14
Jing Zhao, Cuiying Niu, Jianv Wang, Hongxia Yang, Yuzhi Du, Lixin Wei, Cen Li
Background: Zuotai, a famous Tibetan medicinal mixture containing metacinnabar, is traditionally used for the purpose of tranquilizing minds and soothing nerves. However, it still lacks substantial experimental data for it to be approved for use. Aim: This study was designed to assess the effects of Zuotai on depressive-like symptoms in a chronic unpredictable mild stress (CUMS) mouse model, and to explore its potential mechanism, particularly the hypothalamic-pituitary-adrenal (HPA) axis pathway...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29366745/glycyrrhizic-acid-ameliorates-the-kynurenine-pathway-in-association-with-its-antidepressant-effect
#15
Bo Wang, Yong-Jie Lian, Xin Dong, Wei Peng, Lin-Lin Liu, Wen-Jun Su, Hong Gong, Ting Zhang, Chun-Lei Jiang, Jia-Si Li, Yun-Xia Wang
Our previous study implied the role of central high mobility group box 1 (HMGB1) in lipopolysaccharide (LPS)-induced depressive behavior that could partially abrogate by glycyrrhizic acid (GZA). Here, we considered the potential mechanism underlying GZA ameliorating chronic stress-induced depression both in vivo and in vitro. Depression model was established with the 4-week chronic unpredictable mild stress (CUMS) mice or low dose of LPS/HMGB1 administration slices. Sucrose preference test, tail suspension test and open field test were performed to reflect depressive behaviors...
January 20, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29361609/environmental-enrichment-modulates-the-response-to-chronic-stress-in-zebrafish
#16
Matheus Marcon, Ricieri Mocelin, Radharani Benvenutti, Tales Costa, Ana P Herrmann, Diogo L de Oliveira, Gessi Koakoski, Leonardo J G Barcellos, Angelo Piato
Several studies have shown that manipulations to the housing environment modulate the susceptibility to stress in laboratory animals, mainly in rodents. Environmental enrichment (EE) is one such manipulation that promotes neuroprotection and neurogenesis, besides affecting behaviors such as drug self-administration. Zebrafish are a popular and useful animal model for behavioral neuroscience studies; however, studies evaluating the impact of housing conditions in this species are scarce. In this study, we verified the effects of EE on behavioral (novel tank test) and biochemical (cortisol and reactive oxygen species (ROS)) parameters in zebrafish submitted to unpredictable chronic stress (UCS)...
January 9, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29356981/ocimum-basilicum-improve-chronic-stress-induced-neurodegenerative-changes-in-mice-hippocampus
#17
Nasra Naeim Ayuob, Manal Galal Abd El Wahab, Soad Shaker Ali, Hanem Saad Abdel-Tawab
Alzheimer's disease (AD), one of the progressive neurodegenerative diseases might be associated with exposure to stress and altered living conditions. This study aimed to evaluate the effectiveness of Ocimum basilicum (OB) essential oils in improving the neurodegenerative-like changes induced in mice after exposed to chronic unpredictable mild stress (CUMS). Forty male Swiss albino mice divided into four groups (n = 10); the control, CUMS, CUMS + Fluoxetine, CUMS + OB were used. Behavioral tests, serum corticosterone level, hippocampus protein level of the glucocorticoid receptors (GRs) and brain-dreived neurotropic factor (BDNF) were determined after exposure to CUMS...
January 22, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29353879/shifting-priorities-highly-conserved-behavioral-and-brain-network-adaptations-to-chronic-stress-across-species
#18
Yuliya S Nikolova, Keith A Misquitta, Brad R Rocco, Thomas D Prevot, Annchen R Knodt, Jacob Ellegood, Aristotle N Voineskos, Jason P Lerch, Ahmad R Hariri, Etienne Sibille, Mounira Banasr
Parallel clinical and preclinical research have begun to illuminate the biological basis of stress-related disorders, including major depression, but translational bridges informing discrete mechanistic targets for intervention are missing. To address this critical need, we used structural MRI in a mouse model and in a large human sample to examine stress effects on brain structure that may be conserved across species. Specifically, we focused on a previously unexplored approach, whole-brain structural covariance, as it reflects synchronized changes in neuroanatomy, potentially due to mutual trophic influences or shared plasticity across regions...
January 22, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29339018/nicotine-alleviates-chronic-stress-induced-anxiety-and-depressive-like-behavior-and-hippocampal-neuropathology-via-regulating-autophagy-signaling
#19
Xi Xiao, Xueliang Shang, Baohui Zhai, Hui Zhang, Tao Zhang
Recently, we reported that chronic nicotine significantly improved chronic stress-induced impairments of cognition and the hippocampal synaptic plasticity in mice, however, the underlying mechanism still needs to be explored. In the present study, 32 male C57BL/6 mice were divided into four groups: control (CON), stress (CUS), stress with chronic nicotine administration (CUS + Nic) and chronic nicotine administration (Nic). The anxiety-like behavior and neuropathological alteration of DG neurons were examined...
January 12, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29335360/activity-in-the-ventral-medial-prefrontal-cortex-is-necessary-for-the-therapeutic-effects-of-extinction-in-rats
#20
Elizabeth A Fucich, Denisse Paredes, Madeleine O Saunders, David A Morilak
Poor response and high relapse rates remain problematic in the treatment of stress-related psychiatric disorders like depression and posttraumatic stress disorder (PTSD). While mechanisms of pharmacotherapies are intensely studied, little is known about mechanisms of behavioral therapy that could inform improved treatments. We have previously demonstrated the therapeutic effects of extinction learning as a behavioral intervention modeling exposure therapy in rats. In the present study, we tested the hypothesis that activity in the ventral medial prefrontal cortex (vmPFC) during extinction is necessary for its therapeutic effects...
January 15, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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