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chronic unpredictable stress

M Kent, S Scott, S Lambert, E Kirk, B Terhune-Cotter, B Thompson, S Neal, B Dozier, M Bardi, K Lambert
Prior research with a rat model of behavioral therapy [i.e., effort-based reward (EBR) contingency training] suggests that strengthened associations between physical effort and desired outcomes enhance neurobiological indices of resilience. In the current study, male and female Long-Evans rats were exposed to either six weeks of EBR training or noncontingent training prior to 10 days of exposure to chronic unpredictable stress (CUS). Subsequently, all animals were exposed to a problem-solving task and then trained in a spatial learning/foraging task, the dry land maze (DLM)...
June 18, 2018: Neuroscience
M A M Mulders, G S I Sulkers, A J Videler, S D Strackee, M J C Smeulders
Background  Patients with palmar midcarpal instability have symptoms of pain, combined with clinical signs of abnormal mobility on stressing the joint, an unpredictable blockade feeling, and a noticeable clunk, in the absence of an underlying trauma. No data are available on the effect of conservative treatment for these patients. Purpose  The purpose of this study was to evaluate the effect and the long-term functional outcomes of a wrist exercise program in patients with palmar midcarpal instability. Patients and Methods  All patients diagnosed with palmar midcarpal instability between 2005 and 2011 were included...
July 2018: Journal of Wrist Surgery
Melissa T Manners, Nicole L Yohn, Nicholas F Lahens, Gregory R Grant, Marisa S Bartolomei, Julie A Blendy
Adolescent stress can impact health and well-being not only during adulthood of the exposed individual but even in future generations. To investigate the molecular mechanisms underlying these long-term effects, we exposed adolescent males to stress and measured anxiety behaviors and gene expression in the amygdala - a critical region in the control of emotional states - in their progeny for two generations, offspring and grandoffspring. Male C57BL/6 mice underwent chronic unpredictable stress (CUS) for two-weeks during adolescence and were used to produce two generations of offspring...
June 13, 2018: Genes, Brain, and Behavior
Rong Pu, Run-Hui Shao, Jun Lu, Shu-Ying Jin, Ya Tu
OBJECTIVE: To observe the effect of acupuncture intervention on depressive-like behavior and nuclear factor-κB (NF-κB), inducible nitric oxide synthase (iNOS) and nitric oxide (NO) levels in the prefrontal cortex in chronic stress induced depression rats, so as to explore its mechanism underlying antidepressant effect. METHODS: SD rats were randomly divided into control, model, acupuncture and medication (Fluoxetine) groups (8 rats/group). The depression model was established by chro-nic unpredictable stress stimulation (fasting, water deprivation, cold water swimming, tail clamping, constraining, etc...
April 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Anthony L Berger, Angela M Henricks, Janelle M Lugo, Hayden R Wright, Collin R Warrick, Martin A Sticht, Maria Morena, Itziar Bonilla, Sarah A Laredo, Rebecca M Craft, Loren H Parsons, Pedro R Grandes, Cecilia J Hillard, Matthew N Hill, Ryan J McLaughlin
BACKGROUND: The ability to effectively cope with stress is a critical determinant of disease susceptibility. The lateral habenula (LHb) and the endocannabinoid (ECB) system have independently been shown to be involved in the selection of stress coping strategies, yet the role of ECB signaling in the LHb remains unknown. METHODS: Using a battery of complementary techniques in rats, we examined the localization of type-1 cannabinoid receptors (CB1 Rs) and assessed the behavioral and neuroendocrine effects of intra-LHb CB1 R manipulations...
May 8, 2018: Biological Psychiatry
Stacey B Scott, Jinhyuk Kim, Joshua M Smyth, David M Almeida, Martin J Sliwinski
Objectives: Many studies of daily life have framed stressors as unpredictable disruptions. We tested age differences in whether individuals forecast upcoming stressors, whether individuals show anticipatory stress responses prior to stressors, and whether having previously forecasted any stressors moderates stressor exposure on negative affect. Methods: Adults (n=237; age 25-65) completed surveys 5 times daily for 14 days on current negative affect, stressor exposure, and stressor forecasts...
June 6, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Ricieri Mocelin, Matheus Marcon, Simone D'ambros, Juliane Mattos, Adrieli Sachett, Anna M Siebel, Ana P Herrmann, Angelo Piato
There is accumulating evidence on the use of N-acetylcysteine (NAC) in the treatment of patients with neuropsychiatric disorders. As a multi-target drug and a glutathione precursor, NAC is a promising molecule in the management of stress-related disorders, for which there is an expanding field of research investigating novel therapies targeting oxidative pathways. The deleterious effects of chronic stress in the central nervous system are a result of glutamatergic hyperactivation, glutathione (GSH) depletion, oxidative stress, and increased inflammatory response, among others...
June 6, 2018: Molecular Neurobiology
Claudia Carmassi, Martina Corsi, Carlo Antonio Bertelloni, Barbara Carpita, Camilla Gesi, Virginia Pedrinelli, Gabriele Massimetti, Diego Giampietro Peroni, Alice Bonuccelli, Alessandro Orsini, Liliana Dell'Osso
Background: Post-traumatic stress disorder (PTSD) and post-traumatic stress spectrum have been recently applied to understand the impact of life-threatening disease or injury in one's child; nevertheless, scant data are available on a particular chronic illness such as epilepsy whose phenotypic expression is seizures, which are acute, sudden, and unpredictable manifestations. Subjects with bipolar disorders or with mood spectrum symptoms demonstrated to be more vulnerable to develop PTSD in the aftermath of a trauma...
2018: Neuropsychiatric Disease and Treatment
Ke-Ke Jia, Shu-Man Pan, Hong Ding, Jia-Hui Liu, Yan-Jing Zheng, Shui-Juan Wang, Ying Pan, Ling-Dong Kong
Depression is a mental illness comorbid risk factor for glucose intolerance worldwide. Chaihu-shugan san, a 'Shu-Gan' formula in traditional Chinese medicine, is clinically used in the treatment of depression. The aim of this study was to investigate whether Chaihu-shugan san improved glucose tolerance with its antidepressant activity in rat model of depression and explore the mechanisms underlying its action on liver-brain inflammation axis. After 6 weeks of chronic unpredictable mild stress (CUMS) procedure, male Wistar rats were given Chaihu-shugan san water extract (925 and 1850 mg/kg) by gavage for the next 6 consecutive weeks...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Xiaoyan Sun, Zhenhua Song, Yawei Si, Jin-Hui Wang
Chronic stress with lack of reward presumably may impair brain reward circuit, leading to major depressive disorder (MDD). Most individuals experiencing chronic stress do not suffer from MDD, i.e., resilience, implying the presence of endogenous anti-depression in the brain. Molecular mechanisms underlying stress-induced depression versus resilience were investigated. Mice were treated by chronic unpredictable mild stress (CUMS) for four weeks. Their mood state was assessed by behavioral tasks, such as sucrose preference, Y-maze and forced swimming testes...
June 1, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Qiong Liu, Ning-Ning Sun, Zheng-Zhi Wu, Da-Hua Fan, Mei-Qun Cao
Dysregulation of miR-124 has been reported to be involved in the pathophysiology of depression. Chaihu-Shugan-San, a traditional Chinese medicine, has antidepressive activity; however, the underlying mechanisms remain unclear. In this study, to generate a rodent model of depression, rats were subjected to a combination of solitary confinement and chronic unpredictable mild stress for 28 days. Rats were intragastrically administered Chaihu-Shugan-San (2.835 mL/kg/d) for 4 weeks, once a day. Real-time reverse-transcription quantitative polymerase chain reaction, miRNA microarray, western blot assay and transmission electron microscopy demonstrated that Chaihu-Shugan-San downregulated miR-124 expression and upregulated the mRNA and protein levels of mitogen-activated protein kinase 14 (MAPK14) and glutamate receptor subunit 3 (Gria3)...
May 2018: Neural Regeneration Research
Tafnis Ingret Dos Santos Sampaio, Nayara Costa de Melo, Bianca Thais de Freitas Paiva, Gerley Anatê da Silva Aleluia, Fernando Luiz Pinheiro da Silva Neto, Heitor Ribeiro da Silva, Hady Keita, Rodrigo Alves Soares Cruz, Brenda Lorena Sánchez-Ortiz, Elizabeth Arlen Pineda-Peña, José Luis Balderas, Andres Navarrete, José Carlos Tavares Carvalho
ETHNOBOTANICAL RELEVANCE: Spondias mombin L. is a plant dispersed throughout the tropical regions of South America, Africa, and Asia, being found mainly in the North and Northeast of Brazil, where the leaves are used in preparations for neuropsychiatric disorders. Therefore, it is of great importance to carry out studies in different pharmacological models that can prove the traditional use of this plant species. MATERIALS AND METHODS: the hydroethanolic extract from S...
May 28, 2018: Journal of Ethnopharmacology
Nataša Veličković, Ana Teofilović, Dragana Ilić, Ana Djordjevic, Danijela Vojnović Milutinović, Snježana Petrović, Frederic Preitner, Luc Tappy, Gordana Matić
PURPOSE: High-fructose consumption and chronic stress are both associated with metabolic inflammation and insulin resistance. Recently, disturbed activity of energy sensor AMP-activated protein kinase (AMPK) was recognized as mediator between nutrient-induced stress and inflammation. Thus, we analyzed the effects of high-fructose diet, alone or in combination with chronic stress, on glucose homeostasis, inflammation and expression of energy sensing proteins in the rat liver. METHODS: In male Wistar rats exposed to 9-week 20% fructose diet and/or 4-week chronic unpredictable stress we measured plasma and hepatic corticosterone level, indicators of glucose homeostasis and lipid metabolism, hepatic inflammation (pro- and anti-inflammatory cytokine levels, Toll-like receptor 4, NLRP3, activation of NFκB, JNK and ERK pathways) and levels of energy-sensing proteins AMPK, SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α)...
May 29, 2018: European Journal of Nutrition
Xue-Qin Chen, Cheng-Fu Li, Shu-Jiao Chen, Wen-Na Liang, Miao Wang, Shuang-Shuang Wang, Shu-Qi Dong, Li-Tao Yi, Can-Dong Li
Chaihu Shugan San (CSS), a traditional Chinese medicine formula, has been used to treat depression for hundreds of years. Recently, the antidepressant-like mechanism of CSS has been increasingly evaluated and demonstrated. However, there are few studies focused on the involvement of the neurotrophic system in mediating the antidepressant-like effects of CSS. Considering the high prevalence of perimenopausal depression around the world, the goal of the present study was to determine whether brain-derived neurotrophic factor (BDNF) signaling is required for the antidepressant-like effects of CSS in perimenopausal depressive-like rats...
May 26, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Stífani Machado Araujo, Marcia Rósula Poetini, Vandreza Cardoso Bortolotto, Shanda de Freitas Couto, Franciane Cabral Pinheiro, Luana Barreto Meichtry, Francielli Polet de Almeida, Elize Aparecida Santos Musachio, Mariane Trindade de Paula, Marina Prigol
The etiopathogenesis of depression may involve repeated exposure to several unpredictable stressors. This study was conducted to investigate changes induced by chronic unpredictable mild stress (CUMS) and to assess behavioral and neurochemical changes that predict depressive-like behavior in Drosophila melanogaster. Male Drosophila melanogaster flies were exposed to CUMS with several stressors (cold, heat, starvation, and sleep deprivation) in an unpredictable and chronic manner for ten days. At the end of treatment, in vivo behavioral tests (open field, aggression, forced swimming, mating, light/dark box, male fertility evaluation, sucrose preference, weight evaluation) and ex vivo analyses (dopamine and serotonin levels) were performed...
May 24, 2018: Behavioural Brain Research
Guo-Li Wang, Ying-Ping Wang, Jing-Yu Zheng, Lian-Xue Zhang
Ginsenoside Rb1 (Rb1), as the major bioactive ingredient of Panax ginseng C.A. Meyer, elicited a novel antidepressant-like effect in the forced swim test (FST) in chronic unpredictable mild stress (CUMS) rats in our previous study. To further explore the molecular mechanism of Rb1 on the neurotransmitters such as 5-hydroxytryptamine (5-HT), 5-hydroxyindole-3-acetic acid (5-HIAA), norepinephrine (NE), dopamine (DA), homovanillic acid (HVA), dihydroxyphenylacetic acid (DOPAC), glutamate (Glu) and gamma-aminobutyric acid (GABA) in this antidepressant-like effect, the neurochemical changes in the monoaminergic and aminoacidergic receptors were investigated in the present pharmacological study by using reuptake inhibitors, receptors agonists and antagonists...
May 23, 2018: Brain Research
Yichen Song, Ruoxi Sun, Zhouye Ji, Xiaoxi Li, Qiang Fu, Shiping Ma
BACKGROUND: Current evidence supports that inflammatory reaction in the hippocampus is a potential cause of major depressive disorder (MDD). Perilla aldehyde (PAH), a major constituent from Perilla frutescens, has been reported to have anti-inflammatory and anti-oxidant activity. The aim of this study is to explore the antidepressant-like effect and the underlying mechanism of PAH on the rats model induced by chronic unpredictable mild stress (CUMS). METHODS: CUMS rats model was built to tested their depressive-like behaviors...
August 1, 2018: Life Sciences
C Ligon, E Mohammadi, P Ge, G Hannig, C Higgins, B Greenwood-Van Meerveld
BACKGROUND: Irritable bowel syndrome (IBS) and bladder pain syndrome (BPS) are female-predominant, chronic functional pain disorders that are associated with early life stress (ELS) and therapeutic options for such patients remain limited. Linaclotide, a guanylate cyclase-C (GC-C) agonist, relieves abdominal pain and bowel symptoms in adult patients suffering from IBS with constipation. Here, we test the hypothesis that linaclotide will reverse colon and bladder hyperalgesia in a female-specific rodent model of adverse early life experience...
May 24, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Lei Guo, Yi-Xi Chen, Yu-Ting Hu, Xue-Yan Wu, Yang He, Juan-Li Wu, Man-Li Huang, Matthew Mason, Ai-Min Bao
BACKGROUND: Alterations in peripheral sex hormones may play an important role in sex differences in terms of stress responses and mood disorders. It is not yet known whether and how stress-related brain systems and brain sex steroid levels fluctuate in relation to changes in peripheral sex hormone levels, or whether the different sexes show different patterns. We aimed to investigate systematically, in male and female rats, the effect of decreased circulating sex hormone levels following gonadectomy on acute and chronic stress responses, manifested as changes in plasma and hypothalamic sex steroids and hypothalamic stress-related molecules...
May 21, 2018: Psychoneuroendocrinology
Wu Song, Yan Guo, Shuang Jiang, Lin Wei, Zhi Liu, Xiaoyan Wang, Ying Su
Depression is a major social and health problem worldwide. Compound K (CK), an intestinal metabolite of panaxadiol ginsenosides, has been demonstrated to possess significant pharmacological effects on the central nervous system (CNS). Here, we set up this study to investigate the antidepressant effect of CK, and to explore the potential mechanisms underlying this activity. The behavioral despair model and chronic unpredictable mild stress (CUMS) model were established in mice or rats, respectively. Forced swimming test (FST), tail suspension test (TST) and locomotor activity were performed in mice, while the open-field test, food consumption and sucrose preference were assessed in rats...
May 22, 2018: Neurochemical Research
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