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https://www.readbyqxmd.com/read/29329456/designing-and-evaluating-an-automated-system-for-real-time-medication-administration-error-detection-in-a-neonatal-intensive-care-unit
#1
Yizhao Ni, Todd Lingren, Eric S Hall, Matthew Leonard, Kristin Melton, Eric S Kirkendall
Background: Timely identification of medication administration errors (MAEs) promises great benefits for mitigating medication errors and associated harm. Despite previous efforts utilizing computerized methods to monitor medication errors, sustaining effective and accurate detection of MAEs remains challenging. In this study, we developed a real-time MAE detection system and evaluated its performance prior to system integration into institutional workflows. Methods: Our prospective observational study included automated MAE detection of 10 high-risk medications and fluids for patients admitted to the neonatal intensive care unit at Cincinnati Children's Hospital Medical Center during a 4-month period...
January 10, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29322372/examination-of-patient-reported-outcomes-in-association-with-tnf-inhibitor-treatment-response-results-from-a-us-observational-cohort-study
#2
Cynthia J Larmore, Natalie N Boytsov, Carol L Gaich, Xiang Zhang, Andre B Araujo, Sabrina Rebello, Bob A Salim, George W Reed, Leslie R Harrold
INTRODUCTION: Implementation of a treat-to-target strategy is challenging when the patient and physician prioritize different goals. This study aimed to "translate" improvements in Clinical Disease Activity Index (CDAI) to concepts that resonate with patients (such as pain, fatigue, morning stiffness) by examining the association between changes in disease activity and patient-reported outcomes (PROs) in a national cohort of patients with rheumatoid arthritis (RA) initiating their first biologic treatment...
January 10, 2018: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29317463/task-errors-by-emergency-physicians-are-associated-with-interruptions-multitasking-fatigue-and-working-memory-capacity-a-prospective-direct-observation-study
#3
Johanna I Westbrook, Magda Raban, Scott R Walter, Heather Douglas
BACKGROUND: Interruptions and multitasking have been demonstrated in experimental studies to reduce individuals' task performance. These behaviours are frequently used by clinicians in high-workload, dynamic clinical environments, yet their effects have rarely been studied. OBJECTIVE: To assess the relative contributions of interruptions and multitasking by emergency physicians to prescribing errors. METHODS: 36 emergency physicians were shadowed over 120 hours...
January 9, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29315454/patients-opinions-on-outcomes-following-critical-illness
#4
H K Nedergaard, T Haberlandt, P D Reichmann, P Toft, H I Jensen
BACKGROUND: Our aim was to explore which outcomes are most important to patients following ICU-discharge, and to explore whether intensive care unit (ICU)-nurses and anesthesiologists are aware of patients' priorities. METHODS: First, interviews with adult ICU-survivors were conducted until data saturation was achieved (10 interviews), and six areas with 36 items were identified. Second, interviews with another eight ICU-survivors were conducted, narrowing the list to 20...
January 7, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29314645/tofacitinib-with-conventional-synthetic-disease-modifying-antirheumatic-drugs-in-chinese-patients-with-rheumatoid-arthritis-patient-reported-outcomes-from-a-phase-3-randomized-controlled-trial
#5
Zhanguo Li, Yuan An, Houheng Su, Xiangpei Li, Jianhua Xu, Yi Zheng, Guiye Li, Kenneth Kwok, Lisy Wang, Qizhe Wu
AIM: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We assess the effect of tofacitinib + conventional synthetic disease-modifying anti rheumatic drugs (csDMARDs) on patient-reported outcomes in Chinese patients with RA and inadequate response to DMARDs. METHODS: This analysis of data from the Phase 3 study ORAL Sync included Chinese patients randomized 4 : 4 : 1 : 1 to receive tofacitinib 5 mg twice daily, tofacitinib 10 mg twice daily, placebo→tofacitinib 5 mg twice daily, or placebo→tofacitinib 10 mg twice daily, with csDMARDs...
January 4, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29313251/unintentional-and-sequential-lead-exposure-from-a-ceramic-mug-and-maca-lepidium-meyenii
#6
Kelly Johnson-Arbor, Kathy Vo, Flavia Wong, Ryszard Gajek
Although the incidence of lead poisoning has decreased in the USA over the last 30 years, human exposures to lead-containing products are still reported. We present a case of unintentional lead exposure from a store-bought ceramic mug and a nutritional supplement. A 32-year-old female was found to have a whole blood lead concentration of 44 μg/dL. Evaluation of her home, occupation, and hobbies initially did not identify a source of lead exposure. Further investigation revealed that the likely etiology of the exposure was lead leaching from a ceramic mug used by the patient to drink hot lemon water while she was pregnant...
January 8, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29306594/vertebrobasilar-artery-stroke-as-the-heralding-sign-of-systemic-lupus-erythematosus
#7
Reza Mohammadian, Ali Tarighatnia, Mehran Naghibi, Evin Koleini, Nader D Nader
Cerebral ischemia because of vertebrobasilar insufficiency (VBI) rarely presents as an initial sign within the systemic lupus erythematosus (SLE) population, and there are very few case reports supporting this manifestation. This report details 3 different patients with SLE who experienced VBI as an initial manifestation. Patient 1 was a 24-year-old female who developed a bilateral pontine lesion as a consequence of basilar artery stenosis. Patient 2 was a 34-year-old male with an acute ischemic lesion on the right side of his cerebellum and pons because of significant stenosis in the distal segment of the right vertebral artery...
January 3, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29290253/dynamic-change-of-fatigue-of-pemetrexed-maintenance-treatment-in-the-jmen-trial
#8
Li Zhang, Chandra P Belani, Ping-Hai Zhang, Xin Wang, Lulu Yang, Mauro Orlando, Yi-Long Wu
OBJECTIVES: In the JMEN trial, patients with advanced non-squamous non-small cell lung cancer (NSCLC) without progression after platinum-based first-line therapy derived extended survival, delayed disease progression, and maintained overall quality of life (QoL) from pemetrexed maintenance therapy. However, fatigue was the most common physician-reported non-hematological toxicity in the pemetrexed group. This post hoc analysis investigated dynamic change of fatigue. MATERIALS AND METHODS: Analysis of the overall safety population with squamous and non-squamous NSCLC subgroups included Common Terminology Criteria for Adverse Events to summarize adverse event (AE) rates by cycle and AE investigator-reported severity...
January 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29276675/an-onion-farmer-with-a-case-of-hypersensitivity-pneumonitis-caused-by-aspergillus-niger
#9
Tomohiro Sakamoto, Akira Yamasaki, Yoshihiro Funaki, Tomoya Harada, Ryota Okazaki, Yasuyuki Hasegawa, Yuriko Sueda, Takehito Fukushima, Masahito Morita, Akihiro Yamamoto, Masahiro Kodani, Eiji Shimizu
A 62-year old man was admitted to our hospital with a 2-week complaint of a dry cough, general fatigue, and dyspnea on effort. He has been an onion farmer for several years and developed these symptoms after cleaning up onion peels with air compressors. A chest roentgenogram and computed tomography showed a ground glass shadow in the bilateral upper lung field. Cellular analysis of the bronchoalveolar lavage fluid showed elevated total cell numbers and lymphocytes. Transbronchial lung biopsies revealed a non-caseating granuloma with both epithelioid cells and Langhans giant cells...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29247347/patient-and-physician-perspectives-on-the-impact-of-health-related-quality-of-life-in-mexican-patients-with-anca-associated-vasculitis
#10
Andrea Hinojosa-Azaola, Ariadna Jiménez-González, Natasha Alcocer-Castillejos
The objective of this study is to describe aspects of health-related quality of life (HRQOL) in Mexican patients with antineutrophil cytoplasmic-associated vasculitis (AAV). Cross-sectional comparison study includes patients with established AAV and a comparison group with rheumatoid arthritis (RA), chronic kidney disease (CKD), and healthy subjects. Variables considered were: socio-demographic data, comorbidities, laboratory, disease activity, damage, and Physician's and Patient's Global Assessment (PhGA and PtGA)...
December 15, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29237442/factors-impacting-the-illness-trajectory-of-post-infectious-fatigue-syndrome-a-qualitative-study-of-adults-experiences
#11
Eva Stormorken, Leonard A Jason, Marit Kirkevold
BACKGROUND: Post-infectious fatigue syndrome (PIFS), also known as post-viral fatigue syndrome, is a complex condition resulting in physical, cognitive, emotional, neurological, vocational and/or role performance disabilities in varying degrees that changes over time. The needs for health care resources are high, and costly, as is the economic burden on the affected individuals. Many factors may impact the trajectory, and frequently PIFS develops into a chronic condition. Health professionals lack understanding and knowledge, which results in delayed diagnosis, lack of recognition, appropriate treatment, support and practical help...
December 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29233842/doctor-fails-early-warning-signs-of-physician-fatigue
#12
Eleni Linos, Natnaelle Admassu, Hala Sabry-Elnaggar, Peter Mmc Li, Esther Choo
No abstract text is available yet for this article.
December 12, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29231969/patient-reported-outcomes-enhance-the-survival-prediction-of-traditional-disease-risk-classifications-an-international-study-in-patients-with-myelodysplastic-syndromes
#13
Fabio Efficace, Francesco Cottone, Gregory Abel, Pasquale Niscola, Gianluca Gaidano, Franck Bonnetain, Amelie Anota, Giovanni Caocci, Angel Cronin, Luana Fianchi, Massimo Breccia, Reinhard Stauder, Uwe Platzbecker, Giuseppe A Palumbo, Mario Luppi, Rosangela Invernizzi, Micaela Bergamaschi, Lorenza Borin, Anna Angela Di Tucci, Huiyong Zhang, Mirjam Sprangers, Marco Vignetti, Franco Mandelli
BACKGROUND: Current prognostic systems for myelodysplastic syndromes (MDS) are based on clinical, pathologic, and laboratory indicators. The objective of the current study was to develop a new patient-centered prognostic index for patients with advanced MDS by including self-reported fatigue severity into a well-established clinical risk classification: the International Prognostic Scoring System (IPSS). METHODS: A total of 469 patients with advanced (ie, IPSS intermediate-2 or high-risk) MDS were analyzed...
December 12, 2017: Cancer
https://www.readbyqxmd.com/read/29225915/mdhaq-rapid3-scores-in-patients-with-osteoarthritis-are-similar-to-or-higher-than-in-patients-with-rheumatoid-arthritis-a-cross-sectional-study-from-current-routine-rheumatology-care-at-four-sites
#14
Carlos El-Haddad, Isabel Castrejon, Kathryn A Gibson, Yusuf Yazici, Martin J Bergman, Theodore Pincus
Objective: To compare patients with a primary diagnosis of osteoarthritis (OA) versus rheumatoid arthritis (RA) for scores on a patient self-report MDHAQ/RAPID3 (Multidimensional Health Assessment Questionnaire/Routine Assessment of Patient Index Data 3), and for physician global assessment (DOCGL). Methods: All patients with all diagnoses complete an MDHAQ/RAPID3 at all routine rheumatology visits in the waiting area before seeing a rheumatologist at four sites, one in Australia and three in the USA...
2017: RMD Open
https://www.readbyqxmd.com/read/29212827/diet-quality-is-associated-with-disability-and-symptom-severity-in-multiple-sclerosis
#15
Kathryn C Fitzgerald, Tuula Tyry, Amber Salter, Stacey S Cofield, Gary Cutter, Robert Fox, Ruth Ann Marrie
OBJECTIVE: To assess the association between diet quality and intake of specific foods with disability and symptom severity in people with multiple sclerosis (MS). METHODS: In 2015, participants in the North American Research Committee on MS (NARCOMS) Registry completed a dietary screener questionnaire that estimates intake of fruits, vegetables and legumes, whole grains, added sugars, and red/processed meats. We constructed an overall diet quality score for each individual based on these food groups; higher scores denoted a healthier diet...
January 2, 2018: Neurology
https://www.readbyqxmd.com/read/29190726/socio-demographic-health-related-and-individual-correlates-of-diagnostic-self-testing-by-lay-people-results-from-a-representative-survey-in-germany
#16
Pinar Kuecuekbalaban, Silke Schmidt, Manfred Beutel, Kerstin Weidner, Martina de Zwaan, Elmar Braehler, Holger Muehlan
INTRODUCTION: A broad range of self-tests (testing for e.g. HIV, cancer, hepatitis B/C) have become available and can be conducted by lay consumers without the help of a health professional. The aims of this study were to (a) investigate the prevalence of self-testing, (b) identify the most frequently used self-tests, and (c) explore the associations between socio-demographic, health-related and individual factors with self-testing. METHODS: A face-to-face plus paper-pencil cross-sectional survey was conducted...
2017: PloS One
https://www.readbyqxmd.com/read/29183032/return-to-work-of-cancer-survivors
#17
Ulf Seifart, Jan Schmielau
Due to improving treatment options, the number of so-called long-term cancer survivors is steadily increasing. Current studies assume that more than 60% of adults survive their cancer. These patients have a variety of problems (chemotherapy-induced neuropathy, fatigue, etc.) that require very special care. In addition to somatic and psychological side effects of the cancer or its treatment, these patients also suffer from the financial and social consequences of the disease. Thus, for a long-term survivor of working age, the question of a 'return to work' represents a significant problem since otherwise the financial existence of the patient, and often the family, may substantially deteriorate...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29183022/rehabilitation-of-cancer-survivors-with-long-term-toxicities
#18
Jan Schmielau, Oliver Rick, Monika Reuss-Borst, Eva-Maria Kalusche-Bontemps, Monika Steimann
The prognosis of cancer patients is constantly improving, which increases the importance of securing long-term quality of life. While therapy of treatment-related disability mostly succeeds a cancer-specific treatment, physicians' awareness of simultaneous supportive therapy is rising. Early interventions such as physical exercise during chemotherapy are effective in reducing conditions such as fatigue. Specific sensorimotor training is able to improve or even prevent impairment of balance caused by neurotoxic agents...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29182007/approaching-recovery-from-myalgic-encephalomyelitis-and-chronic-fatigue-syndrome-challenges-to-consider-in-research-and-practice
#19
Andrew R Devendorf, Carly T Jackson, Madison Sunnquist, Leonard A Jason
There are unique methodological challenges to studying and assessing recovery in myalgic encephalomyelitis and chronic fatigue syndrome. This study explored these challenges through interviewing 13 physicians who treat myalgic encephalomyelitis and chronic fatigue syndrome. Our deductive thematic analysis produced four themes to consider when approaching recovery: lifespan differences in the illness experience; the heterogeneity of myalgic encephalomyelitis and chronic fatigue syndrome-case definitions, etiological stance, and misdiagnosis; patient follow-up and selection bias; and assessment logistics...
November 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/29174200/group-2-adrenal-insufficiency-screening-methods-and-confirmation-of-diagnosis
#20
Philippe Chanson, Laurence Guignat, Bernard Goichot, Olivier Chabre, Dinane Samara Boustani, Rachel Reynaud, Dominique Simon, Antoine Tabarin, Damien Gruson, Yves Reznik, Marie-Laure Raffin Sanson
A diagnosis of adrenal insufficiency should be suspected in the presence of a number of non-specific symptoms (fatigue, anorexia, weight loss, hypotension, hyponatremia and hyperkalemia amongst adrenal causes of insufficiency). The diagnosis should be considered in case of pituitary disease or a state of shock. Treatment should be commenced immediately without waiting for confirmation from biochemical tests, which rely on cortisol level at 8am (expected to be low) and on ACTH level (expected to be high in the case of primary adrenal insufficiency)...
December 2017: Annales D'endocrinologie
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