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https://www.readbyqxmd.com/read/29785939/exploring-an-integrative-patient-tailored-complementary-medicine-approach-for-chemotherapy-induced-taste-disorders
#1
Eran Ben-Arye, Ilana Doweck, Elad Schiff, Noah Samuels
CONTEXT: Chemotherapy-induced taste disorder (CITD) is a common adverse effect among patients with cancer, with no effective known treatment. OBJECTIVES: Exploring the impact of a patient-tailored complementary and integrative medicine (CIM) treatment program on CITD-related severity. DESIGN: Prospective study on patients' chart. SETTING: Integrative oncology program operating within the Clalit Healthcare Oncology Service in northern Israel...
April 22, 2018: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/29779086/retrospective-study-of-nivolumab-for-patients-with-recurrent-high-grade-gliomas
#2
Megan Mantica, Ashley Pritchard, Frank Lieberman, Jan Drappatz
INTRODUCTION: Patients with recurrent high-grade gliomas (HGG) have limited treatment options. HGG utilize the PD-1 pathway to evade immune responses. Checkpoint inhibitors have demonstrated safety and clinical activity in patients with recurrent glioblastoma. We explored the efficacy of nivolumab in recurrent HGG with a primary objective of progression free survival (PFS) and overall survival (OS). METHODS: We retrospectively analyzed HGG patients treated with nivolumab in our institution...
May 19, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29778457/treatment-of-chronic-obstructive-pulmonary-disease-in-the-primary-care-setting-how-can-we-achieve-more-for-our-patients
#3
Barbara Yawn, Barry Make
Chronic obstructive pulmonary disease (COPD) is a debilitating and progressive disease that is both under-diagnosed and under-treated, affecting up to 1 in 10 older adults. Common symptoms, including dyspnea, productive cough, chest tightness, and fatigue, can reduce quality of life, ability to participate in all types of activities, and overall health status in patients. Minimizing the impact of symptoms on patients' quality of life should be a key goal for physicians and modest changes in current practice could make improvements in patients' lives...
May 17, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29777436/fatigue-related-risk-management-in-the-emergency-department-a-focus-group-study
#4
Pierre Bérastégui, Mathieu Jaspar, Alexandre Ghuysen, Anne-Sophie Nyssen
Fatigue has major implications on both patient safety and healthcare practitioner's well-being. Traditionally, two approaches can be used to reduce fatigue-related risk: reducing the likelihood of a fatigued operator working (i.e. fatigue reduction), or reducing the likelihood that a fatigued operator will make an error (i.e. fatigue proofing). Recent progress mainly focussed on fatigue reduction strategies such as reducing work hours. Yet it has to be recognized that such approach has not wholly overcome the experience of fatigue...
May 18, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29763935/comorbidities-are-associated-with-altered-health-services-use-in-multiple-sclerosis-a-prospective-cohort-study
#5
Kyla A McKay, Ruth Ann Marrie, John D Fisk, Scott B Patten, Helen Tremlett
BACKGROUND: Persons with multiple sclerosis (MS) use health resources with greater frequency than the general population. However, little is known regarding which patient characteristics might contribute. OBJECTIVE: The study aimed to evaluate characteristics associated with healthcare use in MS patients. METHODS: Consecutive MS clinic attendees were recruited (September-November 2010), with clinical, demographic, and patient-completed questionnaires collected at 3 visits over 2 years...
May 15, 2018: Neuroepidemiology
https://www.readbyqxmd.com/read/29756588/toward-a-shared-care-model-of-relapsing-remitting-multiple-sclerosis-role-of-the-primary-care-practitioner
#6
Jiwon Oh, Marie-Sarah Gagné-Brosseau, Melanie Guenette, Catherine Larochelle, François Lemieux, Suresh Menon, Sarah A Morrow, Laurence Poliquin-Lasnier, Chantal Roy-Hewitson, Carolina Rush, Anne-Marie Trudelle, Paul S Giacomini
The objective of this study was to develop a shared-care model to enable primary-care physicians to participate more fully in meeting the complex, multidisciplinary healthcare needs of patients with multiple sclerosis (MS). DESIGN: The design consisted of development of consensus recommendations and a shared-care algorithm. PARTICIPANTS: A working group of 11 Canadian neurologists involved in the management of patients with MS were included in this study. MAIN MESSAGE: The clinical management of patients with multiple sclerosis is increasing in complexity as new disease-modifying therapies (DMTs) become available, and ongoing safety monitoring is required...
May 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29724486/computer-based-monitoring-and-evaluation-of-epilepsy-related-health-variables-and-their-impact-on-treatment-decision
#7
Melanie Bergmann, Manuela Prieschl, Gerald Walser, Gerhard Luef, Gerhard Rumpold, Iris Unterberger
OBJECTIVE: This study aimed to determine the effectiveness of electronic patient-reported outcomes (ePROs) with focus on epilepsy-specific quality of life, psychiatric and psychosocial burden, drug side effects, and patient satisfaction via the Computer-based Health Evaluation System (CHES) and to evaluate their impact on treatment regimen. METHODS: Forty consecutive patients with drug-resistant focal epilepsy undergoing prolonged video-electroencephalography (EEG) monitoring at the Department of Neurology, Innsbruck Medical University were included and randomized to an intervention group (questionnaire results accessible to the physicians) and a control group (questionnaire results inaccessible to the physicians)...
April 30, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29708517/neuropathic-pain-component-in-axial-spondyloarthritis-and-the-influence-on-disease-burden
#8
Kevser Gok, Gizem Cengiz, Kemal Erol, Salih Ozgocmen
OBJECTIVES: Patients with nonradiographic axial spondyloarthritis (nr-axSpA) and radiographic axSpA/ankylosing spondylitis (AS) have similar burden of disease; however, the potential influence of pain characteristics including the neuropathic pain (NeP) component has not been assessed yet. The aim of this study was first to assess frequency of NeP component in patients with axSpA and second to assess the potential influence of NeP on burden of disease. METHODS: Adult patients who met the Assessment of SpondyloArthritis International Society classification criteria for axSpA were consecutively recruited...
February 22, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29703851/efficacy-and-safety-of-faecal-microbiota-transplantation-in-patients-with-psoriatic-arthritis-protocol-for-a-6-month-double-blind-randomised-placebo-controlled-trial
#9
Maja Skov Kragsnaes, Jens Kjeldsen, Hans Christian Horn, Heidi Lausten Munk, Finn Moeller Pedersen, Hanne Marie Holt, Jens Kristian Pedersen, Dorte Kinggaard Holm, Henning Glerup, Vibeke Andersen, Ulrich Fredberg, Karsten Kristiansen, Robin Christensen, Torkell Ellingsen
INTRODUCTION: An unbalanced intestinal microbiota may mediate activation of the inflammatory pathways seen in psoriatic arthritis (PsA). A randomised, placebo-controlled trial of faecal microbiota transplantation (FMT) infused into the small intestine of patients with PsA with active peripheral disease who are non-responsive to methotrexate (MTX) treatment will be conducted. The objective is to explore clinical aspects associated with FMT performed in patients with PsA. METHODS AND ANALYSIS: This trial is a randomised, two-centre stratified, double-blind (patient, care provider and outcome assessor), placebo-controlled, parallel-group study...
April 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29703768/long-term-neuropsychological-outcome-following-pediatric-anti-nmdar-encephalitis
#10
Marienke A A M de Bruijn, Femke K Aarsen, Marielle P van Oosterhout, Marieke M van der Knoop, Coriene E Catsman-Berrevoets, Marco W J Schreurs, Danielle E M Bastiaansen, Peter A E Sillevis Smitt, Rinze F Neuteboom, Maarten J Titulaer
OBJECTIVE: To provide detailed long-term outcome data of children and adolescents following pediatric anti- N -methyl-d-aspartate receptor (anti-NMDAR) encephalitis, to identify neuropsychological impairments, and to evaluate the influence of these factors on quality of life (QoL). METHODS: All Dutch children diagnosed with anti-NMDAR encephalitis were identified. Patients currently aged 4 years or older were included in the follow-up study, consisting of a visit to our clinic for a detailed interview and a standardized neuropsychological assessment...
April 27, 2018: Neurology
https://www.readbyqxmd.com/read/29698345/presenting-signs-and-symptoms-of-pericardial-effusions-in-the-pediatric-emergency-department
#11
Matthew Cully, Jason R Buckley, Elysha Pifko, Olivia M Titus
OBJECTIVES: The primary objective of this study was to describe the frequency of the most common presenting signs and symptoms of pericardial effusions, particularly with relation to the size of the effusion. The secondary objective was to review the final etiology of the pericardial effusion in those patients who had presented to a tertiary care pediatric emergency department. METHODS: This was a retrospective chart review of patients younger than 17 years who presented and were evaluated at the pediatric emergency department and subsequently diagnosed with a pericardial effusion during a period of 10 years...
April 24, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29697038/tree-analysis-modeling-of-the-associations-between-phq-9-depressive-symptoms-and-doctor-diagnosis-of-depression-in-primary-care
#12
Weng-Yee Chin, Eric Yuk Fai Wan, Christopher Dowrick, Bruce Arroll, Cindy Lo Kuen Lam
BACKGROUND: The aim of this study was to explore the relationship between patient self-reported Patient Health Questionnaire-9 (PHQ-9) symptoms and doctor diagnosis of depression using a tree analysis approach. METHODS: This was a secondary analysis on a dataset obtained from 10 179 adult primary care patients and 59 primary care physicians (PCPs) across Hong Kong. Patients completed a waiting room survey collecting data on socio-demographics and the PHQ-9. Blinded doctors documented whether they thought the patient had depression...
April 26, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29694652/impact-of-pregnancy-on-sexuality-a-cross-sectional-study-of-100-tunisian-women
#13
Talel Badri, Amira Maamri, Yousri El Kissi
BACKGROUND: Pregnancy is a period during which anatomical, physiological and psychological changes may affect couple sexuality. AIM: To determine the knowledge and practices in sexuality, and identify the particularities of the sexual function during pregnancy. METHODS: A cross-sectional, descriptive and analytical study of pregnant women who responded to a questionnaire sent by Internet through a social network. RESULTS: Ninety-one percent of the 100 enrolled women were aged 25 to 34 years; 97% had a university education, and 66% were in the third quarter...
July 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29691685/adherence-and-health-literacy-as-related-to-outcome-of-patients-treated-for-rheumatoid-arthritis-analyses-of-a-large-scale-observational-study
#14
J G Kuipers, M Koller, F Zeman, K Müller, J U Rüffer
BACKGROUND: Disabilities in daily living and quality of life are key endpoints for evaluating the treatment outcome for rheumatoid arthritis (RA). Factors possibly contributing to good outcome are adherence and health literacy. METHODS: The survey included a representative nationwide sample of German rheumatologists and their patients with RA. The physician questionnaire included the disease activity score (DAS28) and medical prescriptions. The patient questionnaire included fatigue (EORTC QLQ-FA13), health assessment questionnaire (HAQ), quality of life (SF-12), health literacy (HELP), and patients' listings of their medications...
April 24, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29681202/quality-of-life-in-psoriatic-arthritis
#15
Tania Gudu, Laure Gossec
Psoriatic arthritis (PsA) is a multi-organ chronic inflammatory disease which impacts patients both physically and psychologically. The highest priority for patients goes to pain relief, but also to ability to function and participate in social life, fatigue, and psychological distress. Areas covered: In the present article, we will review current knowledge on impairments of health-related quality of life related to PsA, as well as patient priorities and patient-reported outcome measures such as the PsA Impact of Disease or the PsA Quality of Life questionnaires...
April 23, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29665805/determinants-of-illness-specific-social-support-and-its-relation-to-distress-in-long-term-melanoma-survivors
#16
Sabine Fischbeck, Veronika Weyer-Elberich, Sylke R Zeissig, Barbara H Imruck, Maria Blettner, Harald Binder, Manfred E Beutel
BACKGROUND: Social support is considered to be one of the most important resources for coping with cancer. However, social interactions may also be detrimental, e. g. disappointing or discouraging. The present study explored: 1. the extent of illness-specific positive aspects of social support and detrimental interactions in melanoma survivors, 2. their relationships to mental health characteristics (e. g. distress, quality of life, fatigue, coping processes, and dispositional optimism) and 3...
April 17, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29661620/tolerability-safety-and-outcomes-of-neoadjuvant-chemoradiotherapy-with-capecitabine-for-patients-aged-%C3%A2-70-years-with-locally-advanced-rectal-cancer
#17
Lotte Jacobs, Ellen van der Vlies, Daan Ten Bokkel Huinink, Haiko Bloemendal, Martijn Intven, Anke B Smits, Bas L A M Weusten, Peter D Siersema, Niels van Lelyveld, Maartje Los
INTRODUCTION: In studies of colorectal cancer, the elderly have been frequently underrepresented because comorbid conditions and functional status often lead to study exclusion. For elderly patients with an indication for neoadjuvant chemoradiotherapy (nCRT), physicians usually decide using clinical factors whether nCRT should be offered. The aim of the present retrospective study was to assess the tolerability of nCRT with capecitabine and the surgical outcomes in patients aged ≥ 70 years with locally advanced rectal cancer...
March 8, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29653069/breathing-exercises-must-be-a-real-and-effective-intervention-to-consider-in-women-with-fibromyalgia-a-pilot-randomized-controlled-trial
#18
Pablo Tomás-Carús, Jaime C Branco, Armando Raimundo, José A Parraca, Nuno Batalha, Clarissa Biehl-Printes
BACKGROUND/OBJECTIVE: Respiratory problems can aggravate pain located in the coincident areas with tender points in the upper half of the body in patients with fibromyalgia (FM) and easily become fatigued, thus can lead to a decrease in the functionality of daily activities. The purpose of this study was to examine the effects of a breathing exercises program on pain thresholds tolerance on tender points and FM impact on daily life. METHODS/DESIGN: Thirty-five women with FM (age 34-67 years) were randomly assigned to an exercise group (n = 18), performing breathing exercises (30 min/session, 7 times/week; for 12 weeks), or to a control group (n = 17)...
April 13, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29620972/an-online-survey-of-hypothyroid-patients-demonstrates-prominent-dissatisfaction
#19
Sarah J Peterson, Anne R Cappola, M Regina Castro, Colin M Dayan, Alan P Farwell, James V Hennessey, Peter A Kopp, Douglas S Ross, Mary H Samuels, Anna M Sawka, Peter N Taylor, Jacqueline Jonklaas, Antonio C Bianco
BACKGROUND: Approximately 15% more patients taking levothyroxine (LT4) report impaired quality of life compared to controls. This could be explained by additional diagnoses independently affecting quality of life and complicating assignment of causation. This study sought to investigate the underpinnings of reduced quality of life in hypothyroid patients and to provide data for discussion at a symposium addressing hypothyroidism. METHODS: An online survey for hypothyroid patients was posted on the American Thyroid Association Web site and forwarded to multiple groups...
April 5, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29614980/chemoradiotherapy-versus-chemotherapy-as-adjuvant-treatment-for-localized-gastric-cancer-a-propensity-score-matched-analysis
#20
Daniel M Girardi, Mariana A de Lima, Gabriel C B Pereira, Marcelo V Negrão, Rossana V M López, Fernanda C Capareli, Jorge Sabbaga, Paulo Marcelo G Hoff
BACKGROUND: Treatment of localized gastric cancer (LGC) consists of surgical resection followed by adjuvant treatment. Both chemoradiation (CRT) and chemotherapy (CT) regimens have shown benefit in survival outcomes versus observation. However, there are few data comparing these approaches. METHODS: This study included consecutive patients with LGC treated at Instituto do Cancer do Estado de Sao Paulo (ICESP) from 2012 to 2015. CRT was based on the INT-0116 regimen and CT consisted of a platinum and fluoropyrimidine doublet...
April 3, 2018: BMC Cancer
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