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food antibiotic residues

Amos Kosgey, Anakalo Shitandi, Jason W Marion
Milk vending machines (MVMs) are growing in popularity in Kenya and worldwide. Milk vending machines dispense varying quantities of locally sourced, pasteurized milk. The Kenya Dairy Board has a regulatory framework, but surveillance is weak because of several factors. Milk vending machines' milk is not routinely screened for antibiotics, thereby increasing potential for antibiotic misuse. To investigate, a total of 80 milk samples from four commercial providers ( N = 25), street vendors ( N = 21), and three MVMs ( N = 34) were collected and screened in Eldoret, Kenya...
March 19, 2018: American Journal of Tropical Medicine and Hygiene
Khurram Muaz, Muhammad Riaz, Saeed Akhtar, Sungkwon Park, Amir Ismail
Poultry production is among the most rapidly growing industries around the globe, and poultry is one of the major sources of meat. Poultry farmers use disease preventive and growth promoter antibiotics for faster growth of chickens in the shortest possible time to increase the rate of feed assimilation and to lower the incidence of mortality caused by a pathogen attack. Antibiotics may result in dysfunctionality of beneficial gut microbiota and increase resistance among microbial pathogens in poultry. Residues of these antibiotics in poultry meat have been determined in many of the studies globally and are considered one of the possible causes of antibacterial resistance in human pathogens...
March 14, 2018: Journal of Food Protection
Marianne Smith Edge, Mary Elizabeth Kunkel, Jennifer Schmidt, Constantina Papoutsakis
In the late 20th century, plant breeders began using molecular biology techniques such as recombinant DNA, also known as genetic engineering, along with traditional cross-breeding. Ten plant and one animal food have been approved for commercialization in the United States. Today, foods and ingredients from genetically engineered (GE) crops are present throughout the food supply, which has led to varying levels of acceptance. Much discussion exists among consumers and health professionals about the believability of statements made regarding benefits or risks of GE foods...
March 8, 2018: Journal of the Academy of Nutrition and Dietetics
N R Efimochkina, V V Stetsenko, I V Bykova, Yu M Markova, A S Polyanina, A I Aleshkina, S A Sheveleva
Specific features for the development of resistance in Campylobacter jejuni strains were studied after treatment with antibiotics of 6 pharmacological groups. Populations of 18 native strains of C. jejuni (isolated from raw poultry products) and their subcultures (obtained after 2-3-fold stress exposures to antimicrobial agents in subinhibitory doses) were examined to evaluate the expression of phenotypic antibiotic resistance. Genotypic properties of strains were studied by the PCR with primers that detect the presence of genes for resistance to aminoglycosides (aphA-1, aphA-3, and aphA-7), tetracyclines (tetO), and quinolones (GZgyrA)...
March 5, 2018: Bulletin of Experimental Biology and Medicine
Jon Ashley, XiaoTong Feng, Yi Sun
In this study, we developed a new type of multifunctional molecularly imprinted polymer (MIP) composite as an all-in-one biosensor for the low-cost, rapid and sensitive detection of doxycycline in pig plasma. The MIP composite consisted of a magnetic core for ease of manipulation, and a shell of fluorescent MIPs for selective recognition of doxycycline. By simply incorporating a small amount of fluorescent monomer (fluorescein-O-acrylate), the fluorescent MIP layer was successfully grafted onto the magnetic core via a surface imprinting technique...
May 15, 2018: Talanta
Michael Pérez-Rodríguez, Roberto Gerardo Pellerano, Leonardo Pezza, Helena Redigolo Pezza
Tetracyclines are widely used for both the treatment and prevention of diseases in animals as well as for the promotion of rapid animal growth and weight gain. This practice may result in trace amounts of these drugs in products of animal origin, such as milk and eggs, posing serious risks to human health. The presence of tetracycline residues in foods can lead to the transmission of antibiotic-resistant pathogenic bacteria through the food chain. In order to ensure food safety and avoid exposure to these substances, national and international regulatory agencies have established tolerance levels for authorized veterinary drugs, including tetracycline antimicrobials...
May 15, 2018: Talanta
Christine Schwake-Anduschus, Georg Langenkämper
BACKGROUND: Antibiotic drugs are excreted to a large proportion by livestock. Thus, antibiotics are distributed on fields with slurry and can be taken up by plants. Hydroponic experiments were performed to reveal whether the widely administered chlortetracycline is taken up into wheat grain in a concentration dependent manner. A further goal was to determine (chlor)tetracyclines in wheat and rye grain from agricultural practice. RESULTS: Increasing chlortetracycline deposition in wheat grain was observed with rising chlortetracycline spiking level in the hydroponic solution...
February 27, 2018: Journal of the Science of Food and Agriculture
Kalmia E Kniel, Deepak Kumar, Siddhartha Thakur
The philosophy of One Health is growing in concept and clarity. The interdependence of human, animal, and environmental health is the basis for the concept of One Health. One Health is a comprehensive approach to ensure the health of people, animals, and the environment through collaborative efforts. Preharvest food safety issues align with the grand concept of One Health. Imagine any food production system, and immediately, parallel images from One Health emerge: for example, transmission of zoonotic diseases, antibiotic residues, or resistance genes in the environment; environmental and animal host reservoirs of disease; challenges with rearing animals and growing fresh produce on the same farm; application and transport of manure or diseased animals...
February 2018: Microbiology Spectrum
Min Zhang, Yuanlong Shan, Hongtao Gao, Bin Wang, Xin Liu, Yuanyuan Dong, Xiuming Liu, Na Yao, Yonggang Zhou, Xiaowei Li, Haiyan Li
BACKGROUND: Antibiotic residues can cause antibiotic resistance in livestock and their food safety-related issues have increased the consumer demand for products lacking these residues. Hence, developing safe and effective antibiotic alternatives is important to the animal feed industry. With their strong antibacterial actions, antimicrobial peptides have potential as antibiotic alternatives. RESULTS: We investigated the antibacterial and immunomodulatory activities and the mechanisms of action of an antimicrobial peptide...
February 5, 2018: Microbial Cell Factories
Yuan Long, Bin Li, Huan Liu
As antibiotic residue becomes more and more serious all over the world, a rapid and effective detection method is needed to evaluate the antibiotic residue in feed matrices to ensure food safety for consumers. In this study, three different kinds of fluoroquinolones (norfloxacin, enrofloxacin, and ofloxacin) in feed matrices were analyzed using terahertz (THz) spectroscopy, respectively. Meanwhile, pure fluoroquinolones and pure feed matrices were also measured in the same way. Then, the absorption spectra of all of the samples were extracted in the transmission mode...
January 20, 2018: Applied Optics
Sagar Dhakal, Kuanglin Chao, Qing Huang, Moon Kim, Walter Schmidt, Jianwei Qin, C Leigh Broadhurst
Therapeutic and subtherapeutic use of veterinary drugs has increased the risk of residue contamination in animal food products. Antibiotics such as tetracycline are used for mastitis treatment of lactating cows. Milk expressed from treated cows before the withdrawal period has elapsed may contain tetracycline residue. This study developed a simple surface-enhanced Raman spectroscopic (SERS) method for on-site screening of tetracycline residue in milk and water. Six batches of silver colloid nanoparticles were prepared for surface enhancement measurement...
February 1, 2018: Sensors
Li'na Qiao, Sihua Qian, Yuhui Wang, Shifeng Yan, Hengwei Lin
Fluorescent carbon dots (CDs) have received considerable attention in recent years due to their superior optical properties. To take further advantages of these unique features, herein, a CDs-based "lab-on-a-nanoparticle" approach for the detection and discrimination of antibiotics is developed. The sensing platform was designed on the basis of the different channel's fluorescence recoveries or further quenching of the full-colour emissive CDs (F-CDs) and metal ions ensembles with the addition of antibiotics...
January 25, 2018: Chemistry: a European Journal
Rocío Rodríguez-Gómez, María Teresa García-Córcoles, Morsina Çipa, Dolores Barrón, Alberto Navalón, Alberto Zafra-Gómez
Seventeen quinolone antibiotics were determined in cows' milk. A method of high sensitivity, selectivity and accuracy was developed. Accuracy (trueness and precision), linearity, sensitivity, selectivity, decision limit and detection capability were established following the recommendations of the Commission Decision 2002/657/EC and the Food and Drug Administration (FDA) guideline. The use of polar stir-bar sorptive extraction (SBSE) prior to UHPLC-MS/MS analysis is proposed. The variables that affect SBSE were optimized using multivariate optimization strategies...
January 25, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Aurélien Desmarchelier, Kaïli Fan, Mai Minh Tien, Marie-Claude Savoy, Adrienne Tarres, Denis Fuger, Alexandre Goyon, Thomas Bessaire, Pascal Mottier
A procedure for screening 105 veterinary drugs in foods by liquid chromatography tandem mass-spectrometry (LC-MS/MS) is presented. Its scope encompasses raw materials of animal origin (milk, meat, fish, egg and fat) but also related processed ingredients and finished products commonly used and manufactured by food business operators. Due to the complexity of the matrices considered and to efficiently deal with losses during extraction and matrix effects during MS source ionisation, each sample was analyzed twice, that is "unspiked" and "spiked at the screening target concentration" using a QuEChERS-like extraction...
January 18, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Li-Jing Du, Ling Yi, Li-Hong Ye, Yu-Bo Chen, Jun Cao, Li-Qing Peng, Yu-Ting Shi, Qiu-Yan Wang, Yu-Han Hu
A simple and effective method of miniaturized solid-phase extraction (mini-SPE) was developed for the simultaneous purification and enrichment of macrolide antibiotics (MACs) (i.e. azithromycin, clarithromycin, erythromycin, lincomycin and roxithromycin) from honey and skim milk. Mesoporous MCM-41 silica was synthesized and used as sorbent in mini-SPE. Several key parameters affecting the performance of mini-SPE procedure were thoroughly investigated, including sorbent materials, amount of sorbent and elution solvents...
January 3, 2018: Journal of Chromatography. A
Thomas Bessaire, Claudia Mujahid, Andrea Beck, Adrienne Tarres, Marie-Claude Savoy, Pei-Mun Woo, Pascal Mottier, Aurélien Desmarchelier
A fast and robust high performance liquid chromatography tandem mass spectrometry (LC-MS/MS) screening method was developed for the analysis of β-lactam antibiotics in foods of animal origin: eggs, raw milk, processed dairy ingredients, infant formula, and meat- and fish-based products including baby-foods. QuEChERS extraction with some adaptations enabled twenty-three drugs to be simultaneously monitored. Screening Target Concentrations were set at levels adequate to ensure compliance with current European, Chinese, US and Canadian regulations...
January 11, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Thierry Delatour, Lucie Racault, Thomas Bessaire, Aurélien Desmarchelier
Regulatory agencies and government authorities have established maximum residue limits (MRL) in various food matrices of animal origin for supporting governments and food operators in the monitoring of veterinary drug residues in the food chain, and ultimately in the consumer's plate. Today, about 200 veterinary drug residues from several families, mainly with antibiotic, antiparasitic or anti-inflammatory activities, are regulated in a variety of food matrices such as milk, meat or egg. The current article provides a review of the regulatory framework in milk and muscle including data from Codex Alimentarius, Europe, USA, Canada and China for about 220 veterinary drugs...
January 11, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Shengfeng Huang, Ning Gan, Tianhua Li, You Zhou, Yuting Cao, Youren Dong
An ultrasensitive electrochemical aptasensor for multiplex antibiotics detection based on endonuclease and exonuclease assisted dual recycling amplification strategy was proposed. Kanamycin and chloramphenicol were selected as candidates. Firstly, aptamers of the antibiotics were immobilized on bar A and then binding with their endonuclease labeled complementary DNA strands to construct enzyme-cleavage probes. Secondly, The nano zirconium-metal organic framework (NMOF) particles with 1,4-benzene-dicarboxylate (BDC) as linker was defined as UiO-66...
March 1, 2018: Talanta
Xiaolu Yu, Hang Liu, Chengjun Pu, Junhao Chen, Ying Sun, Lin Hu
A modified quick, easy, cheap, effective, rugged, and safe method was established for simultaneous extraction and cleanup of multiple antibiotics in leafy vegetables, and ultra-high performance liquid chromatography with tandem mass spectrometry was used for analysis. Antibiotics in leafy vegetables were extracted with citric acid/sodium citrate in mixed solvents consisting of acetonitrile/methanol (85:15, v/v) from 10 g of vegetables. Octadecylsilyl and graphitized carbon black were used as dispersant adsorbents...
February 2018: Journal of Separation Science
Fausto Scoppetta, Marco Sensi, Maria Pia Franciosini, Marinella Capuccella
Antibiotic use in food-producing animals has considerable impact on public health, especially with respect to the development and spread of antibiotic resistance. Pigs represent one of the main species in which antibiotics are frequently used for different purposes. Surveillance of antibiotic consumption and dose appropriateness, through novel approaches based on defined daily doses, is strongly needed to assess farms' antibiotic risk, in terms of spread of antibiotic resistance and possibile presence of residues in meat...
August 16, 2017: Italian Journal of Food Safety
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