Jin Ye, Huaping Chen, Kaituo Wang, Yi Wang, Aaron Ammerman, Samjhana Awasthi, Jinbin Xu, Bin Liu, Weikai Li
Biogenic monoamines, vital transmitters orchestrating neurological, endocrinal, and immunological functions1-5 , are stored in secretory vesicles by vesicular monoamine transporters (VMATs) for controlled quantal release6,7 . Harnessing proton antiport, VMATs enrich monoamines ~10,000-fold and sequester neurotoxicants to protect neurons8-10 . VMATs are targeted by an arsenal of therapeutic drugs and imaging agents to treat and monitor neurodegenerative disorders, hypertension, and drug addiction1,8,11-16 . However, the structural mechanisms underlying these actions remain elusive...
March 18, 2024: Nature