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https://www.readbyqxmd.com/read/29166758/clinical-significance-of-anti-dense-fine-speckled-70-antibody-in-patients-with-fibromyalgia
#1
Jisoo Jeong, Dong Hyun Kim, Gun Park, Suyeon Park, Hyun-Sook Kim
Background/Aims: Fibromyalgia (FM) is a common rheumatologic disease characterized by chronic widespread pain, along with various clinical manifestations including atypical autoimmune characteristics. Despite its high prevalence, there remain no approved laboratory tests to identify specific manifestations of FM, or to rule out FM from other rheumatic diseases. Anti-dense fine speckled 70 (anti-DFS70) antibodies were initially identified as a form of anti-nuclear antibodies in a patient with interstitial cystitis...
November 24, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29166571/protective-cerebrovascular-effects-of-hydroxysafflor-yellow-a-hsya-on-ischemic-stroke
#2
Yang Sun, Dong-Ping Xu, Zhen Qin, Peng-Yuan Wang, Bo-Han Hu, Jian-Guang Yu, Yong Zhao, Ben Cai, Yong-Ling Chen, Min Lu, Jian-Guo Liu, Xia Liu
The purpose of the present work was designed to explore protective cerebrovascular effects of hydroxysafflor yellow A (HSYA), and provide preclinical efficacy and mechanism data for its possible application in patients with cerebral ischemia. The protective effect of HSYA on ischemic stroke was evaluated by infarct sizes and neurological scores in Sprague-Dawley (SD) rats with middle cerebral artery occlusion (MCAO). Cerebrovascular permeability was detected by Evans blue dye leakage in MCAO rats. Cerebral blood flow, as well as blood pressure and heart rate were monitored using flow probes in Beagle dogs...
November 19, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29166477/regional-differences-in-infection-control-conditions-in-a-sample-of-primary-health-care-services-in-brazil
#3
Mauro Henrique Nogueira Guimarães de Abreu, Vera Lúcia Silva Resende, Kyu Ha Lee, Antônio Thomaz Gonzaga da Matta-Machado, Jacqueline Rose Starr
International guidelines have pointed out the importance of the physical environment of health care facilities in preventing and controlling infection. We aimed to describe the physical environment of dental care facilities in Brazil in 2014, focusing on characteristics designed to control infections. Exactly 16,202 dental offices in the Brazilian Unified National Health System (SUS) participated in this survey. Trained researchers extracted information about the infection control characteristics of health facilities by using a structured instrument...
November 21, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29166409/post-weaning-high-fat-diet-results-in-growth-cartilage-lesions-in-young-male-rats
#4
Samuel S Haysom, Mark H Vickers, Lennex H Yu, Clare M Reynolds, Elwyn C Firth, Sue R McGlashan
To determine if a high-fat diet (HF) from weaning would result in a pro-inflammatory state and affect joint cartilage, we fed male rats either HF or Chow diet post-weaning, and voluntary wheel exercise (EX) or cage only activity (SED) after 9 weeks of age. At 17 weeks body composition, plasma biomarkers and histomorphology scores of femoro-tibial cartilages of HF-SED, HF-EX, Chow-SED and Chow-EX groups were compared. Food intake and activity were not significantly different between groups. HF diet resulted in significantly higher weight gain, %fat, fat:lean ratio, and plasma leptin, insulin and TNFα concentrations, with significant interactions between diet and exercise...
2017: PloS One
https://www.readbyqxmd.com/read/29166200/effect-of-audiovisual-distraction-on-distress-and-oxygenation-status-in-children-receiving-aerosol-therapy
#5
Ni Luh Putu Shinta Devi, Nani Nurhaeni, Happy Hayati
Aerosol therapy, a treatment for children with disorders of the respiratory system, often causes distress, especially in young children. Distress during aerosol therapy can decrease the effectiveness of the treatment. This study aimed to determine the effect of audiovisual distraction on distress levels and oxygenation status (measured by oxygen saturation and respiratory frequency) in children who receive aerosol therapy for disorders of the respiratory system. A quasi-experimental design was employed, specifically a non-equivalent control group, pre-test-post-test design...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29165831/external-validation-of-the-ita-li-ca-prognostic-system-for-patients-with-hepatocellular-carcinoma-a-multicenter-cohort-study-hep-17-0903
#6
Mauro Borzio, Elena Dionigi, Angelo Rossini, Massimo Marignani, Rodolfo Sacco, Ilario De Sio, Emanuela Bertolini, Giampiero Francica, Anna Giacomin, Giancarlo Parisi, Susanna Vicari, Anna Toldi, Andrea Salmi, Sergio Boccia, Mario Mitra, Fabio Fornari
Several staging systems for HCC have been developed. BCLC is considered the best in predicting survival, although limitations have emerged. Recently the Italian-Liver-Cancer (ITA.LI.CA) prognostic system, integrating the ITA.LI.CA tumor-staging (stages 0, A, B1-3; C) with Child-Pugh score, ECOG-PST, and AFP with a strong ability to predict survival was proposed. Aim of our study was to provide an external validation of the ITA.LI.CA system in an independent real-life occidental cohort of HCCs. METHODS: From September 2008 to April 2016, 1508 cirrhotics with incident HCC were consecutively enrolled in 27 Italian institutions (EpaHCC multi-institutional cohort)...
November 22, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29165812/a-novel-and-validated-prognostic-nomogram-based-on-liver-fibrosis-and-tumor-burden-for-patients-with-hepatocellular-carcinoma-after-curative-resection
#7
Jin-Long Huang, Yi-Peng Fu, Chu-Yu Jing, Yong Yi, Jian Sun, Wei Gan, Zhu-Feng Lu, Jian Zhou, Jia Fan, Shuang-Jian Qiu
BACKGROUND AND OBJECTIVES: Most conventional staging systems were formulated concerning the tumor burden rather than the severity of liver fibrosis, which plays a central role in tumor promotion. The aim of this study was to formulate a prognostic nomogram comprehensively considering these two aspects for HCC after hepatectomy. METHODS: The prognostic significances of the four indicators namely laminin, hyaluronic acid, human procollagen type-III, and collagen type-IV that reflect liver fibrosis were explored in two independent cohorts...
November 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29165568/second-harmonic-generation-reveals-subtle-fibrosis-differences-in-adult-and-pediatric-nonalcoholic-fatty-liver-disease
#8
Feng Liu, Jing-Min Zhao, Hui-Ying Rao, Wei-Miao Yu, Wei Zhang, Neil D Theise, Aileen Wee, Lai Wei
Objectives: Investigate subtle fibrosis similarities and differences in adult and pediatric nonalcoholic fatty liver disease (NAFLD) using second harmonic generation (SHG). Methods: SHG/two-photon excitation fluorescence imaging quantified 100 collagen parameters and determined qFibrosis values by using the nonalcoholic steatohepatitis (NASH) Clinical Research Network (CRN) scoring system in 62 adult and 36 pediatric NAFLD liver specimens. Results: Six distinct parameters identified differences among the NASH CRN stages with high accuracy (area under the curve, 0835-0...
November 20, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29165330/prediction-of-mortality-in-patients-with-isolated-traumatic-subarachnoid-hemorrhage-using-a-decision-tree-classifier-a-retrospective-analysis-based-on-a-trauma-registry-system
#9
Cheng-Shyuan Rau, Shao-Chun Wu, Peng-Chen Chien, Pao-Jen Kuo, Yi-Chun Chen, Hsiao-Yun Hsieh, Ching-Hua Hsieh
Background: In contrast to patients with traumatic subarachnoid hemorrhage (tSAH) in the presence of other types of intracranial hemorrhage, the prognosis of patients with isolated tSAH is good. The incidence of mortality in these patients ranges from 0-2.5%. However, few data or predictive models are available for the identification of patients with a high mortality risk. In this study, we aimed to construct a model for mortality prediction using a decision tree (DT) algorithm, along with data obtained from a population-based trauma registry, in a Level 1 trauma center...
November 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29165067/optimized-virtual-screening-workflow-towards-target-based-polynomial-scoring-functions-for-hiv-1-protease
#10
Val Oliveira Pintro, Walter F Azevedo
BACKGROUND: One key step in the development of inhibitors for an enzyme is the application of computational methodologies to predict protein-ligand interactions. The abundance of structural and ligand-binding information for HIV-1 protease opens up the possibility to apply computational methods to develop scoring functions targeted to this enzyme. OBJECTIVE: Our goal here is to develop an integrated molecular docking approach to investigate protein-ligand interactions with focus on the HIV-1 protease...
November 20, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29164939/using-cbpr-to-decrease-health-disparities-in-a-suburban-latino-neighborhood
#11
Maren J Coffman, Brisa Urquieta de Hernandez, Heather A Smith, Andrew McWilliams, Yhenneko J Taylor, Hazel Tapp, Johanna Claire Schuch, Owen Furuseth, Michael Dulin
INTRODUCTION: This project tested the feasibility of using a community-based participatory research (CBPR) approach to deliver health and social resources in two high-risk, suburban neighborhoods. METHOD: An established research network was used to engage stakeholders to design and deliver a neighborhood-based intervention targeting a Latino immigrant population. The intervention provided screenings for hypertension, diabetes, and depression; primary care provider visits; and information about navigating health care delivery systems and related community-based resources...
September 2017: Hispanic Health Care International: the Official Journal of the National Association of Hispanic Nurses
https://www.readbyqxmd.com/read/29164830/changes-in-erectile-function-after-photoselective-vaporization-of-the-prostate-with-a-120-w-greenlight-high-performance-system-laser-2-year-follow-up
#12
Juhyun Park, Sung Yong Cho, Min Chul Cho, Hyeon Jeong, Hwancheol Son
PURPOSE: To evaluate the impact of photoselective vaporization of the prostate (PVP) with a 120-W GreenLight high-performance system on erectile function in a 2-year follow-up study. MATERIALS AND METHODS: One hundred seventy-seven patients who underwent PVP during 2008 to 2012 were analyzed retrospectively. The patients were divided into 5 groups according to their preoperative 5-item International Index of Erectile Function (IIEF-5) scores: Group I (IIEF-5: 5~7, n=28), II (IIEF-5: 8~11, n=47), III (IIEF-5: 12~16, n=43), IV (IIEF-5: 17~21, n=34), and V (IIEF-5: 22~25, n=25)...
November 16, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/29164628/technical-note-response-time-evolution-of-xr-qa2-gafchromic-tm-film-models
#13
Saad Aldelaijan, Nada Tomic, Pavlos Papaconstadopoulos, James Schneider, Jan Seuntjens, Shelley Shih, David Lewis, Slobodan Devic
PURPOSE: To evaluate the response of the newest XR-QA2 GafChromic(™) film model in terms of post-exposure signal growth and energy response in comparison with the older XR-QA (Version 2) model. METHODS: Pieces of film were irradiated to air kerma in air values up to 12 cGy with several beam qualities (5.3-8.25 mm Al) commonly used for CT scanning. Film response was scored in terms of net reflectance from scanned film images at various points in time post-irradiation ranging from 1 to 7 days and 5 months post exposure...
November 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/29164585/expression-and-clinical-significance-of-mir-181a-and-mir-203-in-systemic-lupus-erythematosus-patients
#14
H-S Li, Y Ning, S-B Li, P-Y Shao, S-J Chen, Q Ye, X Heng
OBJECTIVE: MiR-181a plays a critical role in modulating T cell and B cell differentiation, as well as immune response. Its abnormal expression probably participates in the pathogenesis of systemic lupus erythematosus (SLE). MiR-203 is involved in regulating Toll-like receptor and inducing immune tolerance. Abnormal expression or function of miR-203 is related to multiple auto-immune diseases but its role in SLE remains unclear. This study, thus, investigated the serum level of miR-181a and miR-203, to analyze their roles in diagnosing and evaluating SLE...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164570/von-willebrand-factor-and-adamts13-plasma-in-older-patients-with-high-cha2ds2-vasc-score-with-and-without-atrial-fibrillation
#15
F Zhang, X-C Yang, X-W Jia, X-H Tang, Z Wang, Z-Q Wang
OBJECTIVE: Ischemic stroke risk rises with the increasing cardiovascular risk factors in patients with and without AF. How atrial fibrillation (AF) incrementally contributes to the risk for ischemic stroke with increasing age and multiple cardiovascular risk factors is unclear. Von Willebrand factor (vWF) is a biomarker of endothelial dysfunction. PATIENTS AND METHODS: We suggested that in older patients with high CHA2DS2-VASc Score, the vWF and ADAMTS13 would be comparable between patients with and without AF...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164547/-the-effectiveness-of-a-strategy-for-the-flexible-management-of-nursing-human-resources-a-pilot-study
#16
Chung-I Huang, Meei-Shiow Lu
BACKGROUND: The flexibility of a hospital's nursing-related human resource management policies affects the working willingness and retention of nurses. PURPOSE: To explore the effectiveness of a flexible nursing-related human resource management strategy. METHODS: This quasi-experimental research used a one group pretest-posttest design. Supervisors at participating hospitals attended the "Application of Flexible Nursing Human Resources Management Strategies" workshop, which introduced the related measures and assessed nurses' pretest satisfaction...
December 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29164450/accuracy-of-early-ct-findings-for-predicting-disease-course-in-patients-with-acute-pancreatitis
#17
Onur Taydas, Emre Unal, Ali Devrim Karaosmanoglu, Mehmet Ruhi Onur, Erhan Akpinar
PURPOSE: To investigate whether computed tomography (CT)-based scoring systems obtained within 72 h of symptoms onset can predict disease course in acute pancreatitis. METHODS: Between October 2007 and December 2015, 189 patients (age range 21-93 years) who underwent abdominopelvic CT for the diagnosis of acute pancreatitis were included in the study. Balthazar grade and original and modified versions of CT severity index (CTSI) measurements were carried out for each patient...
November 21, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29164429/red-blood-cell-distribution-width-as-a-related-factor-of-pulmonary-arterial-hypertension-in-patients-with-systemic-sclerosis
#18
Jiuliang Zhao, Hongnan Mo, Xiaoxiao Guo, Qian Wang, Dong Xu, Yong Hou, Zhuang Tian, Yongtai Liu, Hui Wang, Jinzhi Lai, Mengtao Li, Xiaofeng Zeng
The aim of this study was to investigate the utility of red blood cell distribution width (RDW) as a simple and readily available marker of occurrence of pulmonary arterial hypertension (PAH) in patients with systemic sclerosis (SSc). One hundred and forty-five consecutive patients with SSc were recruited to the single-center cross-sectional study. Demographic characteristics, hematological parameters, Modified Rodnan Skin Score, and World Health Organization functional classification were determined. Diagnosis of PAH was based on screening by echocardiography and was confirmed by right heart catheterization...
November 21, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29164428/the-value-of-high-sensitivity-c-reactive-protein-in-hand-and-knee-radiographic-osteoarthritis-data-from-the-dong-gu-study
#19
Lihui Wen, Min-Ho Shin, Ji-Hyoun Kang, Yi-Rang Yim, Ji-Eun Kim, Jeong-Won Lee, Kyung-Eun Lee, Dong-Jin Park, Tae-Jong Kim, Yong-Wook Park, Sun-Seog Kweon, Young-Hoon Lee, Yong-Woon Yun, Shin-Seok Lee
Due to the inconsistent association between high-sensitivity C-reactive protein (hs-CRP) and osteoarthritis (OA), we evaluated the relationship between hs-CRP and various radiographic findings in older adults with OA. This cross-sectional study recruited 2376 participants from the population-based Dong-gu cohort. The scores of radiographic features in OA on X-rays of the knees and hands were computed using a semi-quantitative grading system. The hs-CRP levels were measured using a particle-enhanced immunonephelometry assay...
November 21, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29164391/association-between-low-diastolic-blood-pressure-and-subclinical-myocardial-injury
#20
George S Waits, Wesley T O'Neal, Pratik B Sandesara, Yabing Li, Amit J Shah, Elsayed Z Soliman
BACKGROUND: Coronary arteries perfuse cardiac myocytes during diastole. We hypothesized that marked lowering of diastolic blood pressure (DBP) is associated with increased risk of subclinical myocardial injury (SC-MI). METHODS: This analysis included 6107 participants without history of cardiovascular disease (CVD) from the third National Health and Nutrition Examination Survey. SC-MI was determined by a validated electrocardiogram-based scoring system. Logistic regression was used to examine the cross-sectional association between DBP (< 70, 70-80 mmHg (reference group), and > 80 mmHg; and per each 10 mmHg decrease, separately) with SC-MI across levels of systolic blood pressure (SBP) (< 120, 120-139, or > 140 mmHg)...
November 21, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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