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https://www.readbyqxmd.com/read/29793188/prioritization-of-reproductive-toxicants-in-unconventional-oil-and-gas-operations-using-a-multi-country-regulatory-data-driven-hazard-assessment
#1
Salmaan H Inayat-Hussain, Masao Fukumura, A Muiz Aziz, Chai Meng Jin, Low Wei Jin, Rolando Garcia-Milian, Vasilis Vasiliou, Nicole C Deziel
BACKGROUND: Recent trends have witnessed the global growth of unconventional oil and gas (UOG) production. Epidemiologic studies have suggested associations between proximity to UOG operations with increased adverse birth outcomes and cancer, though specific potential etiologic agents have not yet been identified. To perform effective risk assessment of chemicals used in UOG production, the first step of hazard identification followed by prioritization specifically for reproductive toxicity, carcinogenicity and mutagenicity is crucial in an evidence-based risk assessment approach...
May 21, 2018: Environment International
https://www.readbyqxmd.com/read/29793115/estimating-chemical-ecotoxicity-in-eu-ecolabel-and-in-eu-product-environmental-footprint
#2
Erwan Saouter, An De Schryver, Rana Pant, Serenella Sala
The EU Commission Ecolabel and the Product and Environmental Footprint (PEF) aim at promoting the development and consumption of greener products. The product aquatic toxicity score from these 2 methods may lead in some circumstances to opposite conclusions. Although this could be interpreted as an inconsistency, the score should not be compared to each other but used in a complementary way. In short, CDV provided a "full" product formula aquatic toxicity score, even if some chemicals may never reach or persist in freshwater ecosystems...
May 21, 2018: Environment International
https://www.readbyqxmd.com/read/29792299/a-simple-evidence-based-approach-to-help-guide-diagnosis-of-heart-failure-with-preserved-ejection-fraction
#3
Yogesh N V Reddy, Rickey E Carter, Masaru Obokata, Margaret M Redfield, Barry A Borlaug
Background -Diagnosis of heart failure with preserved ejection fraction (HFpEF) is challenging in euvolemic patients with dyspnea, and no evidence-based criteria are available. We sought to develop and then validate non-invasive diagnostic criteria that could be used to estimate the likelihood that HFpEF is present among patients with unexplained dyspnea in order to guide further testing. Methods -Consecutive patients with unexplained dyspnea referred for invasive hemodynamic exercise testing were retrospectively evaluated...
May 23, 2018: Circulation
https://www.readbyqxmd.com/read/29792175/pulse-actinomycin-d-as-first-line-treatment-of-low-risk-post-molar-non-choriocarcinoma-gestational-trophoblastic-neoplasia
#4
Lei Li, Xirun Wan, Fengzhi Feng, Tong Ren, Junjun Yang, Jun Zhao, Fang Jiang, Yang Xiang
BACKGROUND: Little data exists predicting the resistance to actinomycin D (Act-D) single-agent for gestational trophoblastic neoplasia (GTN). The objective was to determine the overall success of pulse Act-D and the factors predictive of resistance to pulse Act-D in the treatment of low-risk, non-choriocarcinoma post-molar GTN. METHODS: From January 2013 to October 2016, according to the FIGO criteria for the diagnosis of post-molar disease and the FIGO risk-factor scoring system for GTN, a total of 135 patients with post-molar non-choriocarcinoma GTN who were chemotherapy-naive with a FIGO score < 7 were treated with single-agent pulse Act-D as a first-line regimen, in Peking Union Medical College Hospital...
May 23, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29792051/predicting-suicide-attempts-and-suicide-deaths-following-outpatient-visits-using-electronic-health-records
#5
Gregory E Simon, Eric Johnson, Jean M Lawrence, Rebecca C Rossom, Brian Ahmedani, Frances L Lynch, Arne Beck, Beth Waitzfelder, Rebecca Ziebell, Robert B Penfold, Susan M Shortreed
OBJECTIVE: The authors sought to develop and validate models using electronic health records to predict suicide attempt and suicide death following an outpatient visit. METHOD: Across seven health systems, 2,960,929 patients age 13 or older (mean age, 46 years; 62% female) made 10,275,853 specialty mental health visits and 9,685,206 primary care visits with mental health diagnoses between Jan. 1, 2009, and June 30, 2015. Health system records and state death certificate data identified suicide attempts (N=24,133) and suicide deaths (N=1,240) over 90 days following each visit...
May 24, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29791902/the-molecular-pathology-of-myelodysplastic-syndrome
#6
Torsten Haferlach
The diagnosis and classification of myelodysplastic syndromes (MDS) are based on cytomorphology and cytogenetics (WHO classification). Prognosis is best defined by the Revised International Prognostic Scoring System (IPSS-R). In recent years, an increasing number of molecular aberrations have been discovered. They are already included in the classification (e.g., SF3B1) and, more importantly, have emerged as valuable markers for better classification, particularly for defining risk groups. Mutations in genes such as SF3B1 and IDH1/2 have already had an impact on targeted treatment approaches in MDS...
May 23, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29791696/monocenter-experience-with-532-nm-laser-photoselective-vaporization-of-the-prostate-by-greenlight-xps%C3%A2-laser-is-it-really-an-endourological-joker-card
#7
Jamil Ghahhari, Carlo D'Orta, Ambra Rizzoli, Michele Marchioni, Giulia I Primicer, Piergustavo De Francesco, Angelo Civitella, Mario Di Lecce, Pietro Castellan, Roberto Castellucci, Fabio Neri, Fabiola Raffaella Tamburro, Luca Cindolo, Luigi Schips
INTRODUCTION: In our study, we reported on our monocenter experience with GreenLight (GL) Xcelerated Performance System (XPS)™ /MoXy™ laser fiber (American Medical Systems Inc., Minnetonka, Minnesota), examining its efficacy, safety, and its ability to effectively treat lower urinary tract symptoms (LUTS) in benign prostate obstruction (BPO). We also explored and compared the three different endoscopic approaches used for GL treatment of benign prostatic hyperplasia (BPH), standard photovaporization (PVP), anatomical PVP, and GreenLight XPS™ enucleation of the prostate...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791675/development-of-a-diet-quality-index-adapted-for-pregnant-women
#8
Lívia Castro Crivellenti, Daniela Cristina Candelas Zuccolotto, Daniela Saes Sartorelli
OBJECTIVE: To develop a Diet Quality Index Adapted for Pregnant Women (IQDAG) and to evaluate its relation with the characteristics of women treated at the Brazilian Unified Health System. METHODS: The data on food intake come from a cross-sectional study carried out with 785 adult pregnant women in the city of Ribeirão Preto, state of São Paulo, Brazil, between 2011 and 2012. The index was based on the recommendations of the Brazilian Ministry of Health, previous national dietary indexes, and the new Dietary Guidelines for the Brazilian Population...
2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29791311/protective-effects-of-persian-honey-apis-mellifera-meda-skorikov-on-side-effects-of-chemotherapy-and-ischemia-reperfusion-induced-testicular-injury
#9
Mohammadreza Gholami, Abolfazl Abbaszadeh, Parastoo Baharvand, Afshin Hasanvand, Amin Hasanvand, Anneh Mohammad Gharravi
Introduction The aim of the present study was to survey the protective effect of pretreatment with Persian honey on amelioration of side effects of chemotherapy and ischemia/reperfusion induced testicular injury. Materials and methods Forty adult's male wistar rats were divided into four groups of ischemia-reperfusion (IR), honey + ischemia-reperfusion (HIR), Busulfan (B) and Busulfan intraperitoneally+ honey (BH). The seminiferous tubules were rated for their modified spermatogenesis index (SI) by Johnsons score...
May 23, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29791247/a-randomized-trial-of-a-family-support-intervention-in-intensive-care-units
#10
Douglas B White, Derek C Angus, Anne-Marie Shields, Praewpannarai Buddadhumaruk, Caroline Pidro, Cynthia Paner, Elizabeth Chaitin, Chung-Chou H Chang, Francis Pike, Lisa Weissfeld, Jeremy M Kahn, Joseph M Darby, Amy Kowinsky, Susan Martin, Robert M Arnold
Background Surrogate decision makers for incapacitated, critically ill patients often struggle with decisions related to goals of care. Such decisions cause psychological distress in surrogates and may lead to treatment that does not align with patients' preferences. Methods We conducted a stepped-wedge, cluster-randomized trial involving patients with a high risk of death and their surrogates in five intensive care units (ICUs) to compare a multicomponent family-support intervention delivered by the interprofessional ICU team with usual care...
May 23, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791201/performance-of-an-additional-task-during-level-2-automated-driving-an-on-road-study-comparing-drivers-with-and-without-experience-with-partial-automation
#11
Ignacio Solís-Marcos, Christer Ahlström, Katja Kircher
OBJECTIVE: To investigate the influence of prior experience with Level 2 automation on additional task performance during manual and Level 2 partially automated driving. BACKGROUND: Level 2 automation is now on the market, but its effects on driver behavior remain unclear. Based on previous studies, we could expect an increase in drivers' engagement in secondary tasks during Level 2 automated driving, but it is yet unknown how drivers will integrate all the ongoing demands in such situations...
May 1, 2018: Human Factors
https://www.readbyqxmd.com/read/29791196/determining-success-or-failure-after-foot-and-ankle-surgery-using-patient-acceptable-symptom-state-pass-and-patient-reported-outcome-information-system-promis
#12
Michael R Anderson, Judith F Baumhauer, Benedict F DiGiovanni, Sam Flemister, John P Ketz, Irvin Oh, Jeffrey R Houck
BACKGROUND: As the role of generic patient-reported outcomes (PROs) expands, important questions remain about their interpretation. In particular, how the Patient Reported Outcome Measurement Instrumentation System (PROMIS) t score values correlate with the patients' perception of success or failure (S/F) of their surgery is unknown. The purposes of this study were to characterize the association of PROMIS t scores, the patients' perception of their symptoms (patient acceptable symptom state [PASS]), and determination of S/F after surgery...
May 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29790996/dna-methylation-and-inflammation-marker-profiles-associated-with-a-history-of-depression
#13
Bethany Crawford, Zoe Craig, Georgina Mansell, Isobel White, Adam Smith, Steve Spaull, Jennifer Imm, Eilis Hannon, Andrew Wood, Hanieh Yaghootkar, Yingjie Ji, Niamh Mullins, Cathryn M Lewis, Jonathan Mill, Therese M Murphy
Depression is a common and disabling disorder, representing a major social and economic health issue. Moreover, depression is associated with the progression of diseases with an inflammatory etiology including many inflammatory-related disorders. At the molecular level, the mechanisms by which depression might promote the onset of these diseases and associated immune-dysfunction are not well understood. In this study we assessed genome-wide patterns of DNA methylation in whole blood-derived DNA obtained from individuals with a self-reported history of depression (n = 100) and individuals without a history of depression (n = 100) using the Illumina 450K microarray...
May 22, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29790988/evaluation-of-a-music-therapy-social-skills-development-program-for-youth-with-limited-resources
#14
Varvara Pasiali, Cherie Clark
Background: Children living in low-resource communities are at risk for poorer socio-emotional development and academic performance. Emerging evidence supports use of group music therapy experiences to support social development through community afterschool programming. Objective: To examine the potential benefit of a music therapy social skills development program to improve social skills and academic performance of school-aged children with limited resources in an afterschool program...
May 21, 2018: Journal of Music Therapy
https://www.readbyqxmd.com/read/29790790/the-effects-of-amantadine-on-traumatic-brain-injury-outcome-a-double-blind-randomized-controlled-clinical-trial
#15
Hossein Ghalaenovi, Arash Fattahi, Jalil Koohpayehzadeh, Mahmoud Khodadost, Neda Fatahi, Morteza Taheri, Alireza Azimi, Sadra Rohani, Hessam Rahatlou
INTRODUCTION: Amantadine, as a dopamine receptor agonist, may stimulate and help the recovery of the nervous system after traumatic brain injury (TBI). METHODS: We performed this study as a double-blind, randomized, controlled clinical trial with target population including all patients with TBI who scored nine or lower on the Glasgow Coma Scale (GCS), admitted to our hospital between January 2013 and April 2014. The protocol included administration of the drug (placebo or amantadine) for 6 weeks and patient evaluation using the GCS and FOUR score on the first, third and seventh days after the drug was started...
May 23, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29790691/the-protective-effect-of-gingko-biloba-in-a-rat-model-of-ovarian-ischemia-reperfusion-injury-improvement-in-histological-and-biochemical-parameters
#16
Nuri Yildirim, Deniz Simsek, Semir Kose, Alkim Gulsah Sahingoz Yildirim, Cagri Guven, Gurkan Yigitturk, Oytun Erbas
BACKGROUND: Ovarian torsion is one of the most common gynecological emergencies, which especially affects women of reproductive age. OBJECTIVES: We aimed to evaluate the effect of Ginkgo biloba (GB) supplementation in ovarian ischemia/ reperfusion injury in an experimental torsion/de-torsion rat model. MATERIAL AND METHODS: This study was carried out in the Ege University Faculty of Medicine in Izmir, Turkey. Thirty mature female Sprague-Dawley albino rats were randomly divided into 5 groups: in Group 1 (control), the abdominal wall was only opened and closed; in the torsion group (Group 2), ischemia was induced for 3 h, using atraumatic vascular clips to create a torsion model; in the torsion/GB group (Group 3), the rats were given 80 mg/kg (oral gavage) of GB 30 min before torsion was induced and the torsion model was formed; in the torsion/de-torsion group (Group 4), the rats underwent 3 h of ischemia and then the vascular clips were removed and reperfusion took place for 3 h; in the torsion/de-torsion/GB group (Group 5), the rats underwent 3 h of ischemia followed by GB (oral gavage) 30 min prior to a 3-h reperfusion period...
May 16, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790656/clinical-characteristics-and-validation-of-bronchiectasis-severity-score-systems-for-post-tuberculosis-bronchiectasis
#17
Hong Wang, Xiao-Bin Ji, Cheng-Wei Li, Hai-Wen Lu, Bei Mao, Shuo Liang, Ke-Bin Cheng, Jiu-Wu Bai, Miguel Angel Martinez-Garcia, Jin-Fu Xu
INTRODUCTION: Lung damage related to tuberculosis is a major contributor to the etiology of bronchiectasis in China. It is unknown whether bronchiectasis severity score systems are applicable in these cases. OBJECTIVES: To evaluate the clinical characteristics and validation of bronchiectasis severity score systems for post-tuberculosis bronchiectasis. METHODS: The study enrolled 596 bronchiectasis patients in Shanghai Pulmonary Hospital between January 2011 and December 2012...
May 23, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29790577/esophageal-igg4-levels-correlate-with-histopathologic-and-transcriptomic-features-in-eosinophilic-esophagitis
#18
Chen E Rosenberg, Melissa K Mingler, Julie M Caldwell, Margaret H Collins, Patricia C Fulkerson, David W Morris, Vincent A Mukkada, Philip E Putnam, Tetsuo Shoda, Ting Wen, Marc E Rothenberg
BACKGROUND: Recent data associate eosinophilic esophagitis (EoE) with IgG4 rather than IgE, but its significance and function have not been determined. Our aims were to measure esophageal IgG4 levels and to determine functional correlations as assessed by histologic and transcriptome analyses. METHODS: This case-control study included pediatric subjects with EoE (≥ 15 eosinophils/HPF) and non-EoE controls. Protein lysates were analyzed for IgA, IgM, and IgG1-IgG4 using the Luminex 100 system; IgE was quantified by ELISA...
May 23, 2018: Allergy
https://www.readbyqxmd.com/read/29790444/data-envelopment-analysis-for-estimating-efficiency-of-intensive-care-units-a-case-study-in-iran
#19
Mohammad Amin Bahrami, Sima Rafiei, Mahdieh Abedi, Roohollah Askari
Purpose As hospitals are the most costly service providers in every healthcare systems, special attention should be given to their performance in terms of resource allocation and consumption. The purpose of this paper is to evaluate technical, allocative and economic efficiency in intensive care units (ICUs) of hospitals affiliated by Yazd University of Medical Sciences (YUMS) in 2015. Design/methodology/approach This was a descriptive, analytical study conducted in ICUs of seven training hospitals affiliated by YUMS using data envelopment analysis (DEA) in 2015...
May 14, 2018: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/29790404/clinical-and-neurophysiological-changes-after-targeted-intrathecal-injections-of-bone-marrow-stem-cells-in-a-c3-tetraplegic-subject
#20
Andrea Jimena Santamaria, Francisco D Benavides, Darcy L DiFede, Aisha Khan, Marietsy V Pujol, W Dalton Dietrich, Antonio Marttos, Barth A Green, Joshua M Hare, James Guest
High-level quadriplegia is a devastating condition with limited treatment options. Bone marrow derived stem cells (BMSCs) are reported to have immunomodulatory and neurotrophic effects in spinal cord injury (SCI). We report a subject with complete C2 SCI who received 3 anatomically targeted intrathecal infusions of BMSCs under a single-patient expanded access IND. She underwent intensive physical therapy and was followed for over 2 years. At end-point, her AIS grade improved from A to B and she recovered focal pressure touch sensation over several body areas...
May 23, 2018: Journal of Neurotrauma
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