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https://www.readbyqxmd.com/read/29679905/qing-brick-tea-qbt-aqueous-extract-protects-monosodium-glutamate-induced-obese-mice-against-metabolic-syndrome-and-involves-up-regulation-transcription-factor-nuclear-factor-erythroid-2-related-factor-2-nrf2-antioxidant-pathway
#1
Wenqi Gao, Changyi Xiao, Jun Hu, Biaoxin Chen, Chunyan Wang, Bangping Cui, Pengyi Deng, Jian Yang, Zhifang Deng
BACKGROUND: Qing brick tea (QBT), traditional and popular beverage for Chinese people, is an important post-fermentation dark tea. Our present study was performed to investigate the ameliorative effects of QBT aqueous extract on metabolic syndrome (Mets) in monosodium glutamate-induced obese mice and the potential mechanisms. METHOD: Monosodium glutamate-induced obese mice were used to evaluate the anti-Mets effects of QBT. Content levels of malonaldehyde (MDA), reactive oxygen species (ROS) and protein carbonylation, antioxidant enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione reductase (GR) in the skeletal muscle were assessed by commercial kits, respectively...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679719/localization-of-cholecystokinin-in-the-zebrafish-retina-from-larval-to-adult-stage
#2
M C Guerrera, F Abbate, G Di Caro, G P Germanà, M Levanti, V Micale, G Montalbano, R Laurà, A Germanà, U Muglia
The peptide hormone cholecistokinin (CCK) plays a key role in the central and peripheral nervous system. It is known to be involved in the digestive physiology and in the regulation of food intake. Moreover, the CCK expression has also been detected in the retina of different vertebrates, including fish, although its biological activity in this tissue remains to be elucidated. In literature no data are yet available about the CCK-immunoreactivity in the zebrafish retina during development. Therefore, the aim of the study was to investigate the distribution of sulfated cholecystokinin octapeptide (CCK8-S) as a well preserved form during evolution in the zebrafish retina from 3days post hatching (dph) until adult stage, using immunohistochemistry in order to elucidate the potential role of this protein in the development and maintenance of normal retinal homeostasis...
April 18, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29679641/ethanol-induced-cardiomyocyte-toxicity-involves-autophagy-nfkb-transcription-factor
#3
Jessica Maiuolo, Alessia Maretta, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Francesca Bosco, Rocco Mollace, Federica Scarano, Ernesto Palma, Miriam Scicchitano, Saverio Nucera, Domenico Sergi, Saverio Muscoli, Santo Gratteri, Carolina Muscoli, Vincenzo Mollace
Chronic ethanol (EtOH) consumption causes early detrimental consequences in many tissues including the myocardium, though the molecular mechanisms leading to the alcoholic cardiomyopathy (ACM) still remain to be elucidated. Here, we studied several biomolecular changes occurring in cardiomyoblasts after their exposure to sublethal concentrations of EtOH and the potential synergistic effect with methylmercury (MM) or doxorubicin (DOXO), which are known to produce direct myocardial dysfunction. In addition, the possible role of autophagic responses and Nuclear Factor kappa-B (NFkB) modulation in early post-alcoholic myocardial damage has been investigated...
April 18, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29679557/acetaminophen-induced-liver-injury-is-attenuated-in-transgenic-fat-1-mice-endogenously-synthesizing-long-chain-n-3-fatty-acids
#4
Ruibing Feng, Yang Wang, Conghui Liu, Chunyan Yan, Hang Zhang, Huanxing Su, Jing X Kang, Chang-Zhen Shang, Jian-Bo Wan
Acetaminophen (APAP) overdose-caused hepatotoxicity is the most commonly cause of drugs-induced liver failurecharacterized by oxidative stress, mitochondrial dysfunction, and cell damage. Therapeutic efficacy of omega-3 polyunsaturated fatty acids (n-3 PUFAs) in several models of liver disease is well documented. However, the impacts of n-3 PUFA on APAP hepatotoxicity are not adequately addressed. In this study, the fat-1 transgenic mice that synthesize endogenous n-3 PUFA and wild type (WT) littermates were injected intraperitoneally with APAP at the dose of 400 mg/kg to induce liver injury, and euthanized at 0 h, 2 h, 4 h and 6 h post APAP injection for sampling...
April 18, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29679289/cross-state-dependency-of-learning-between-tramadol-and-mk-801-in-the-mouse-dorsal-hippocampus-involvement-of-nitric-oxide-no-signaling-pathway
#5
Majid Jafari-Sabet, Shiva Amiri, Ramin Ataee
RATIONALE: Tramadol, an atypical μ-opioid receptor agonist, as a psychoactive drug, is frequently abused by human beings. Understanding the neurobiological mechanisms of drug-associated learning and memory formation may help prevent drug addiction and relapse. Previous study revealed that dorsal hippocampus (CA1) plays a crucial role in the retrieval of tramadol-associated memory and that its role depends on the expression of CA1 N-methyl-D-aspartate (NMDA) receptors (Jafari-Sabet et al...
April 21, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29679285/exploration-of-phyllanthus-acidus-mediated-silver-nanoparticles-and-its-activity-against-infectious-bacterial-pathogen
#6
Cherukuri Sowmya, Vuppalapati Lavakumar, Narayanan Venkateshan, Velayutham Ravichandiran, D V R Saigopal
In our present investigation, synthesis of nontoxic, eco friendly and cost effective silver nanoparticles, Phyllanthus acidus (P. acidus) was used as starting material. The influence of phyto-constituents present in aqueous extracts of Phyllanthus acidus was found to be effective in reduction of silver nitrate to free silver nanoparticles (PA-AgNPs). HPTLC finger print analysis reveals the presence of flavonoid, quercetin in aqueous extracts of Phyllanthus acidus. Surface plasmon racemonance exhibited λ max at 462 nm through UV-Vis spectroscopy...
April 20, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29679075/apkc%C3%AE-dependent-repression-of-yap-is-necessary-for-functional-restoration-of-irradiated-salivary-glands-with-igf-1
#7
Alejandro M Chibly, Wen Yu Wong, Maricela Pier, Hongqiang Cheng, Yongxin Mu, Ju Chen, Sourav Ghosh, Kirsten H Limesand
Xerostomia and salivary hypofunction often result as a consequence of radiation therapy for head and neck cancers, which are diagnosed in roughly 60,000 individuals every year in the U.S. Due to the lack of effective treatments for radiation-induced salivary hypofunction, stem cell-based therapies have been suggested to regenerate the irradiated salivary glands. Pharmacologically, restoration of salivary gland function has been accomplished in mice by administering IGF-1 shortly after radiation treatment, but it is not known if salivary stem and progenitor cells play a role...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678224/evaluation-of-the-mucosal-inflammatory-responses-to-equine-cyathostomins-in-response-to-anthelmintic-treatment
#8
A E Steuer, A T Loynachan, M K Nielsen
Members of Cyathostominae are pervasive parasites of equids that can cause larval cyathostominosis, a potentially life-threatening disease that occurs when a multitude of encysted larvae synchronously excyst from the wall of the large intestine. Moxidectin and fenbendazole are the two current labeled drugs that target the encysted larval stages; however, there is limited knowledge of the local inflammatory response to the larvae and to the two treatments in clinically healthy horses. This study is the first to evaluate the local inflammatory response to cyathostomin larvae and to larvicidal treatment at 2 and 5 weeks post treatment...
May 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29676814/potential-of-carnosine-a-histamine-precursor-in-rat-model-of-bilateral-common-carotid-artery-occlusion-induced-vascular-dementia
#9
Nidhi Tiwari, Pankaj Bhatia, Amit Kumar, Amteshwar S Jaggi, Nirmal Singh
The present study investigates the potential of Carnosine a histamine precursor, in rat model of bilateral common carotid artery occlusion (BCCAo) induced vascular dementia (VaD). Wistar rats were subjected to BCCAo procedure under anesthesia to induce VaD. The rats were subjected to Morris water-maze (MWM) test (6th day onwards post-surgery). MWM test was employed to assess learning and memory of the animals whereby ELT (escape latency time), TSTQ (time spent in target quadrant) and Path length (distance travelled) taken as important parameters...
April 20, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29676776/gene-expression-analysis-of-neuropeptides-in-oral-mucosa-during-periodontal-disease-in-nonhuman-primates
#10
John Ferrin, Jeffrey L Ebersole, Sreenatha Kirakodu, David Jensen, Ahmad Al-Attar, Rebecca Peyyala, M John Novak, Dolph Dawson, Mohanad Al-Sabbagh, Arnold J Stromberg, Luis Orraca, Janis Gonzalez-Martinez, Armando Burgos, Octavio A Gonzalez
BACKGROUND: Neuropeptides (NPs) are innate pivotal regulators of the immunoinflammatory response. Nevertheless, their role in the pathogenesis of the periodontal disease remains unknown. We determined changes in gene expression of 10 NPs and 16 NP receptors (NPRs) coincident with the initiation, progression and resolution of periodontitis. METHODS: The ligature-induced periodontitis model was used in rhesus monkeys (n = 18). Gingival tissue samples were taken at baseline pre-ligature, 2 weeks and 1 month (Initiation), and 3 months (Progression) post-ligation...
April 20, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29676713/-deep-brain-stimulation-for-psychiatric-disorders
#11
M Figee, P R Schuurman, D Denys
- Deep brain stimulation (DBS) corrects pathological activity of neuropsychiatric brain networks with high frequency current via implanted brain electrodes.- DBS is an effective and safe treatment for therapy-refractory obsessive-compulsive disorder and potentially also for therapy-refractory major depressive disorder.- Experimental psychiatric indications for DBS are Tourette syndrome, addiction, anorexia nervosa, post-traumatic stress disorder, autism and schizophrenia.- DBS influences brain networks that are relevant for a variety of psychiatric symptoms...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29676588/lysine-acetyltransferase-inhibitors-structure-activity-relationships-and-potential-therapeutic-implications
#12
Francesco Fiorentino, Antonello Mai, Dante Rotili
Lysine acetylation is a post-translational modification of both histone and nonhistone proteins that is catalyzed by lysine acetyltransferases and plays a key role in numerous biological contexts. The dysregulation of this enzyme activity is implicated in many human pathologies such as cancer, neurological and inflammatory disorders. Many lysine acetyltransferase inhibitors (KATi) have been developed so far, but there is still the need for new, more potent, metabolically stable and selective KATi as chemical tools for studying KAT biology and/or as potential therapeutic agents...
April 20, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29676186/it-takes-one-to-know-one-exploring-patient-dialogue-on-rosacea-web-based-platforms-and-their-potential-for-significant-harm
#13
Laura H Riddoch
BACKGROUND: Rosacea is a non-curable skin condition, leading patients to turn self-management options from web based platforms. Self-management can be dangerous possibly under-reported. AIM: To discover the extent of online material and determine the potential for harm influenced by rosacea internet sources. MATERIALS AND METHODS: Material analysed included search engines, apps, YouTube, forums and Facebook groups. As Facebook and forums were most active, they became the core focus...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29676025/an-unsupervised-automatic-segmentation-algorithm-for-breast-tissue-classification-of-dedicated-breast-computed-tomography-images
#14
Marco Caballo, John M Boone, Ritse Mann, Ioannis Sechopoulos
PURPOSE: To develop and evaluate a new automatic classification algorithm able to identify voxels containing skin, vasculature, adipose and fibroglandular tissue in dedicated breast CT images. METHODS: The proposed algorithm combines intensity and region-based segmentation methods with energy minimizing splines and unsupervised data mining approaches for classifying and segmenting the different tissue types. Breast skin segmentation is achieved by a region growing method which uses constraints from the previously extracted skin centerline to add robustness to the model and to reduce the false positive rate...
April 19, 2018: Medical Physics
https://www.readbyqxmd.com/read/29675416/free-floating-mesothelial-cells-in-pleural-fluid-after-lung-surgery
#15
Arne Kienzle, Andrew B Servais, Alexandra B Ysasi, Barry C Gibney, Cristian D Valenzuela, Willi L Wagner, Maximilian Ackermann, Steven J Mentzer
Objectives: The mesothelium, the surface layer of the heart, lung, bowel, liver, and tunica vaginalis, is a complex tissue implicated in organ-specific diseases and regenerative biology; however, the mechanism of mesothelial repair after surgical injury is unknown. Previous observations indicated seeding of denuded mesothelium by free-floating mesothelial cells may contribute to mesothelial healing. In this study, we investigated the prevalence of mesothelial cells in pleural fluid during the 7 days following pulmonary surgery...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29675269/translation-of-remote-control-regenerative-technologies-for-bone-repair
#16
Hareklea Markides, Jane S McLaren, Neil D Telling, Noura Alom, E'atelaf A Al-Mutheffer, Richard O C Oreffo, Andrew Zannettino, Brigitte E Scammell, Lisa J White, Alicia J El Haj
The role of biomechanical stimuli, or mechanotransduction, in normal bone homeostasis and repair is understood to facilitate effective osteogenesis of mesenchymal stem cells (MSCs) in vitro. Mechanotransduction has been integrated into a multitude of in vitro bone tissue engineering strategies and provides an effective means of controlling cell behaviour towards therapeutic outcomes. However, the delivery of mechanical stimuli to exogenous MSC populations, post implantation, poses a significant translational hurdle...
2018: NPJ Regenerative Medicine
https://www.readbyqxmd.com/read/29673385/risk-based-inspection-as-a-cost-effective-strategy-to-reduce-human-exposure-to-cysticerci-of-taenia-saginata-in-low-prevalence-settings
#17
Bhagyalakshmi Chengat Prakashbabu, Laura Rebecca Marshall, Matteo Crotta, William Gilbert, Jade Cherry Johnson, Lis Alban, Javier Guitian
BACKGROUND: Taenia saginata cysticercus is the larval stage of the zoonotic parasite Taenia saginata, with a life-cycle involving both cattle and humans. The public health impact is considered low. The current surveillance system, based on post-mortem inspection of carcasses has low sensitivity and leads to considerable economic burden. Therefore, in the interests of public health and food production efficiency, this study aims to explore the potential of risk-based and cost-effective meat inspection activities for the detection and control of T...
April 19, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29673373/chorioamnionitis-neuroinflammation-and-injury-timing-is-key-in-the-preterm-ovine-fetus
#18
Ruth Gussenhoven, Rob J J Westerlaken, Daan R M G Ophelders, Alan H Jobe, Matthew W Kemp, Suhas G Kallapur, Luc J Zimmermann, Per T Sangild, Stanislava Pankratova, Pierre Gressens, Boris W Kramer, Bobbi Fleiss, Tim G A M Wolfs
BACKGROUND: Antenatal infection (i.e., chorioamnionitis) is an important risk factor for adverse neurodevelopmental outcomes after preterm birth. Destructive and developmental disturbances of the white matter are hallmarks of preterm brain injury. Understanding the temporal effects of antenatal infection in relation to the onset of neurological injury is crucial for the development of neurotherapeutics for preterm infants. However, these dynamics remain unstudied. METHODS: Time-mated ewes were intra-amniotically injected with lipopolysaccharide at 5, 12, or 24 h or 2, 4, 8, or 15 days before preterm delivery at 125 days gestational age (term ~ 150 days)...
April 19, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29672630/nonclinical-comparability-studies-of-recombinant-human-arylsulfatase-a-addressing-manufacturing-process-changes
#19
Teresa Wright, Aiqun Li, Jason Lotterhand, Anne-Renee Graham, Yan Huang, Nancy Avila, Jing Pan
Recombinant human arylsulfatase A (rhASA) is in clinical development for the treatment of patients with metachromatic leukodystrophy (MLD). Manufacturing process changes were introduced to improve robustness and efficiency, resulting in higher levels of mannose-6-phosphate and sialic acid in post-change (process B) compared with pre-change (process A) rhASA. A nonclinical comparability program was conducted to compare process A and process B rhASA. All doses were administered intrathecally. Pharmacodynamic comparability was evaluated in immunotolerant MLD mice, using immunohistochemical staining of lysosomal-associated membrane protein-1 (LAMP-1)...
2018: PloS One
https://www.readbyqxmd.com/read/29671335/a-decision-support-tool-to-inform-local-suicide-prevention-activity-in-greater-western-sydney-australia
#20
Andrew Page, Jo-An Atkinson, William Campos, Mark Heffernan, Shahana Ferdousi, Adrian Power, Geoff McDonnell, Nereus Maranan, Ian Hickie
OBJECTIVES: This study describes the development of a decision support tool to identify the combination of suicide prevention activities and service priorities likely to deliver the greatest reductions in suicidal behaviour in Western Sydney (Australia) over the period 2018-2028. METHODS: A dynamic simulation model for the WentWest - Western Sydney Primary Health Network population-catchment was developed in partnership with primary health network stakeholders based on defined pathways to mental health care and suicidal behaviour, and which represented the current incidence of suicide and attempted suicide in Western Sydney...
April 1, 2018: Australian and New Zealand Journal of Psychiatry
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