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Marco Krengli, Carla Pisani, Letizia Deantonio
The guidelines of the European and American Societies of Radiation Oncology (GEC-ESTRO and ASTRO) defined the selection criteria to offer partial breast irradiation (PBI) after lumpectomy in patients with low risk breast cancer regardless pre-operative staging. A recent publication by Tallet et al. explored the impact of preoperative magnetic resonance imaging (MRI) on patient eligibility for PBI. From their study, an ipsilateral BC was detected in 4% of patients, excluding these patients from intraoperative radiotherapy (IORT)...
September 2016: Journal of Thoracic Disease
Florence K Keane, Jennifer Y Wo, Cristina R Ferrone, Jeffrey W Clark, Lawrence S Blaszkowsky, Jill N Allen, Eunice L Kwak, David P Ryan, Keith D Lillemoe, Carlos Fernandez-Del Castillo, Theodore S Hong
OBJECTIVES: Improved outcomes with FOLFIRINOX or gemcitabine with nab-paclitaxel in the treatment of metastatic pancreatic adenocarcinoma (PDAC) have prompted incorporation of these regimens into neoadjuvant treatment of locally advanced unresectable PDAC. Whereas some patients remain unresectable on surgical exploration, others are able to undergo resection after intensive neoadjuvant treatment. We evaluated outcomes and toxicity associated with use of intensive neoadjuvant treatment followed by intraoperative radiotherapy (IORT) in combination with resection or exploratory laparotomy...
October 12, 2016: American Journal of Clinical Oncology
Peng Gao, Chengche Tsai, Yuchong Yang, Yingying Xu, Changwang Zhang, Cong Zhang, Longyi Wang, Hongpeng Liu, Zhenning Wang
BACKGROUND: The treatment effects of intraoperative radiotherapy (IORT) for gastric and esophageal cancer remain uncertain. We therefore performed meta-analyses to investigate whether IORT was associated with more favorable oncologic outcomes when compared to non-IORT for patients who have gastric or esophageal cancer. METHODS: PubMed, Embase, and the references of relevant studies were systematically searched up to March 2016. Outcomes were analyzed with fixed-effect or random-effect models, and the meta-analysis was completed with odds ratio (OR), hazards ratio (HR), and 95% confidence intervals (CI) as effect values...
October 4, 2016: Minerva Medica
F Wenz
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
F A Giordano, S Brehmer, B Muerle, G Welzel, E Sperk, F Schneider, S Clausen, P Schmiedek, C Groden, D Hänggi, Y Abo-Madyan, F Wenz
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
A Celejewska, J Wydmanski, W Majewski, G Wozniak, Z Kaniewska-Dorsz
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Y Abo-Madyan, G Welzel, E Sperk, C Neumaier, A Keller, S Clausen, F Schneider, M Ehmann, F Wenz
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
E Sperk, P C Teich, C Weiß, M Sütterlin, F Wenz
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Michał Falco, Bartłomiej Masojć, Magdalena Rolla, Agnieszka Czekała, Jolanta Pietruszewska, Agnieszka Rubik-Leszczyńska, Mirosław Lewocki, Magdalena Łukowiak, Andrzej Kram
BACKGROUND: Novel techniques in oncology provide new treatment opportunities but also introduce different patterns of side effects. Intraoperative radiotherapy (IORT) allows a shortened overall treatment time for early breast cancer either combined with whole breast radiotherapy (WBRT), or alone. Although the early side effects of IORT are well known, data on clinically important late side effects, which require medical intervention, are scarce. AIM: In this study, we analyze risk factors for seroma evacuation more than 6 months after IORT...
May 2016: Reports of Practical Oncology and Radiotherapy
Sandra D Scherer, Jochen Bauer, Anja Schmaus, Christian Neumaier, Carsten Herskind, Marlon R Veldwijk, Frederik Wenz, Jonathan P Sleeman
In patients with low-risk breast cancer, intraoperative radiotherapy (IORT) during breast-conserving surgery is a novel and convenient treatment option for delivering a single high dose of irradiation directly to the tumour bed. However, edema and fibrosis can develop after surgery and radiotherapy, which can subsequently impair quality of life. TGF- β is a strong inducer of the extracellular matrix component hyaluronan (HA). TGF-β expression and HA metabolism can be modulated by irradiation experimentally, and are involved in edema and fibrosis...
2016: PloS One
Tammy Corica, Anna K Nowak, Christobel M Saunders, Max Bulsara, Mandy Taylor, Jayant S Vaidya, Michael Baum, David J Joseph
PURPOSE: To report the first comprehensive investigation of patient-reported cosmesis and breast-related quality of life (QOL) outcomes comparing patients randomized to risk-adapted single-dose intraoperative radiation therapy (TARGIT-IORT) versus external beam radiation therapy (EBRT) on the TARGIT-A trial. METHODS AND MATERIALS: Longitudinal cosmesis and QOL data were collected from a subset of TARGIT-A participants who received TARGIT-IORT as a separate procedure (postpathology)...
September 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Shayna L Showalter, Gina Petroni, Daniel M Trifiletti, Bruce Libby, Anneke T Schroen, David R Brenin, Parchayi Dalal, Mark Smolkin, Kelli A Reardon, Timothy N Showalter
PURPOSE: Existing intraoperative radiation therapy (IORT) techniques are criticized for the lack of image guided treatment planning and energy deposition with, at times, poor resultant dosimetry and low radiation dose. We pioneered a novel method of IORT that incorporates customized, computed tomography (CT)-based treatment planning and high-dose-rate (HDR) brachytherapy to overcome these drawbacks: CT-HDR-IORT. METHODS AND MATERIALS: A phase 1 study was conducted to demonstrate the feasibility and safety of CT-HDR-IORT...
September 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Melinda S Epstein, Melvin J Silverstein, Kevin Lin, Brian Kim, Cristina De Leon, Sadia Khan, Lisa E Guerra, Lincoln Snyder, Colleen Coleman, January Lopez, Ralph Mackintosh, Peter Chen
Intraoperative radiation therapy (IORT) delivers radiation therapy directly to the tumor bed at the time of surgery. Minimal data are available regarding IORT complications in patients diagnosed with ductal carcinoma in situ (DCIS) using the Xoft(®) Axxent eBx(®) System. 146 patients with pure DCIS received X-ray based IORT therapy using the Xoft(®) Axxent eBx(®) System at Hoag Memorial Hospital Presbyterian between June 2010 to April 2016 and were accrued to an IORT data registry study. The protocols were approved by the institutional review board and met the guidelines of their responsible governmental agency...
August 4, 2016: Breast Journal
Daniel J Bourgeois, Sai Yendamuri, Mark Hennon, Jorge Gomez, Harish Malhotra, Lalith Kumaraswamy, Iris Wang, Todd Demmy
BACKGROUND: By avoiding chest wall resection, iridium-192 (Ir-192) high-dose-rate (HDR) intraoperative brachytherapy (IOBT) and video-assisted thoracoscopic surgery (VATS) might improve outcomes for high-risk patients requiring surgical resection for pulmonary malignancy with limited pleura and/or chest wall involvement. METHODS AND MATERIALS: Seven patients with non-small cell lung cancer involving the pleura or chest wall underwent VATS pulmonary resections combined with HDR IOBT...
May 7, 2016: Practical Radiation Oncology
Melinda Epstein, Melvin Silverstein, Kevin Lin, Brian Kim, Sadia Khan, Cristina De Leon, Lisa Guerra, Lincoln Snyder, Colleen Coleman, January Lopez, Ralph Mackintosh, Peter Chen
INTRODUCTION: Intraoperative radiation therapy (IORT) permits the delivery of radiation therapy directly to the tumor bed at the time of surgery. Minimal data are available about the complications associated with this modality of treatment using the Xoft(®) Axxent Electronic Brachytherapy (Axxent) System. METHODS: A total of 702 patients who received IORT using the Xoft(®) Axxent System at Hoag Memorial Hospital Presbyterian between June 2010-February 2016 were accrued in an IORT data registry study...
October 2016: Annals of Surgical Oncology
Florian Ebner, Amelie Schramm, Dirk Bottke, Thomas Wp Friedl, Thomas Wiegel, Visnja Fink, Kristian Lato, Inga Bekes, Wolfgang Janni, Nikolaus de Gregorio
INTRODUCTION: One of the most common complications in breast conserving surgery is seroma formation. The origin of seroma formation remains unclear. While intraoperative radiotherapy (IORT) has been shown to be an alternative to whole breast irradiation, the influence on seroma production is unclear. Therefore, this analysis compares seroma production in patients with breast conserving surgery with or without IORT as tumour bed boost during breast conserving surgery. METHOD: A retrospective analysis of seroma production in patients with nodal-negative (pN0sn) pT1/2 primary breast cancer treated between September 2010 and October 2013 at the Breast Cancer Centre, University Hospital Ulm was performed...
October 2016: Archives of Gynecology and Obstetrics
Emanuela Esposito, Rita Compagna, Massimo Rinaldo, Sara Falivene, Vincenzo Ravo, Bruno Amato, Paolo Muto, Massimiliano D'Aiuto
INTRODUCTION: Screening and adjuvant postoperative therapies have increased survival amongst women with breast cancer, but these tools are seldom applied in elderly patients. Higher rates of local recurrence occur in those elderly patients who avoid radiotherapy. TARGIT-A and ELIOT trials has been reported to not to be inferior to external beam RT in suitable subgroups of patients. The TARGIT-Elderly trial has been launched in order to confirm the efficacy of intraoperative radiotherapy (IORT) in a well selected group of elderly patients who are more likely to decline radiation treatment...
September 2016: International Journal of Surgery
Michael G Haddock
Adjuvant therapy with chemoradiation or short-course radiation in addition to improvements in surgical technique has led to improved outcomes for patients with locally advanced rectal cancer. Local recurrence rates of less than 10% and 5-year survival rate of 60% or higher is expected. However, for patients with very locally advanced primary or locally recurrent disease in whom surgical resection is likely to be associated with incomplete resection, survival and disease control rates are poor and standard doses of adjuvant radiation or chemoradiation are relatively ineffective...
July 2016: Seminars in Radiation Oncology
Ahmed Abu-Zaid, Ayman Azzam, Mohammed Abuzaid, Tusneem Elhassan, Naryman Albadawi, Lynn Alkhatib, Osama AlOmar, Abdullah Alsuhaibani, Tarek Amin, Ismail A Al-Badawi
Aim. To report our preliminary single-center experience with cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for management of peritoneal sarcomatosis (PS). Methods. Eleven patients were retrospectively analyzed for perioperative details. Results. Cytoreduction completeness (CC-0/1) was achieved in all patients with median peritoneal cancer index (PCI) of 14 ± 8.9 (range: 3-29). Combination cisplatin + doxorubicin HIPEC chemotherapy was used in 6 patients. Five patients received intraoperative radiation therapy (IORT)...
2016: Gastroenterology Research and Practice
Michela Massa, Simonetta Franchelli, Renzo Panizza, Tiberio Massa
After the results obtained in the two randomized clinical trial, the ELIOT trial and the TARGIT-A trial, a heated debate is going on concerning the question of applying intraoperative radiotherapy (IORT) instead of postoperative whole breast irradiation (WBI) after breast conservative treatment. Currently, many centers are applying the IORT following the strict selection criteria dictated by the working groups American Society for Radiation Oncology (ASTRO) and Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) and monitoring the oncological outcome together with radiation toxicity on breast tissue...
April 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
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