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https://www.readbyqxmd.com/read/27900811/exuberant-squamous-metaplasia-with-calcification-following-intraoperative-radiotherapy-for-breast-carcinoma-report-of-an-unusual-case-and-retrospective-review-of-cases-from-a-single-institution
#1
Paula S Ginter, John Ng, Rebecca Zhuo, Alexander J Swistel, Timothy M D'Alfonso
Intraoperative radiotherapy (IORT) is a novel and increasingly utilized radiation technique in the treatment of breast carcinoma. There are few reports on the histologic changes seen in breast tissue from patients who have undergone IORT. We sought to evaluate the histologic changes observed in specimens received following IORT, as well as report an unusual case which prompted our study. A retrospective review of patients who received IORT and subsequently had breast tissue histologically evaluated at our institution was performed...
November 30, 2016: Breast Journal
https://www.readbyqxmd.com/read/27900058/effect-of-surgical-wound-fluids-after-intraoperative-electron-radiotherapy-on-the-cancer-stem-cell-phenotype-in-a-panel-of-human-breast-cancer-cell-lines
#2
Karolina Zaleska, Wiktoria Maria Suchorska, Anna Przybyła, Dawid Murawa
The wound healing process after surgery alters the area surrounding the original tumor and around the scar, and the modified microenvironment is more favorable for tumor recurrence. Intraoperative radiotherapy (IORT) is one of the more novel strategies in breast cancer (BC) treatment. Irradiation during surgery has effects on the tumor microenvironment, abrogating the proliferative cascade induced by surgical wound healing. The aim of the present study was to determine the effect of surgical wound fluids from IOERT treatment (RT-WF) compared with wound fluids from conservative-breast surgery only (WF) on the cancer stem cell phenotype in a panel of BC cell lines...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27866865/accelerated-partial-breast-irradiation-executive-summary-for-the-update-of-an-astro-evidence-based-consensus-statement
#3
Candace Correa, Eleanor E Harris, Maria Cristina Leonardi, Benjamin D Smith, Alphonse G Taghian, Alastair M Thompson, Julia White, Jay R Harris
PURPOSE: To update the accelerated partial breast irradiation Consensus Statement published in 2009 and provide guidance on use of intraoperative radiation therapy (IORT) for partial breast irradiation in early-stage breast cancer, based on published evidence complemented by expert opinion. METHODS AND MATERIALS: A systematic PubMed search using the same terms as the original Consensus Statement yielded 419 articles; 44 articles were selected. The authors synthesized the published evidence and, through a series of conference calls and e-mails, reached consensus regarding the recommendations...
September 17, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27861907/factors-predictive-of-failure-to-complete-planned-intraoperative-breast-radiation-using-the-intrabeam%C3%A2-system
#4
Lesly A Dossett, Andrea M Abbott, Weihong Sun, Loretta Loftus, Marie Catherine Lee, Roberto Diaz, Christine Laronga
PURPOSE: Intraoperative radiation therapy (IORT) is a form of breast irradiation that is delivered in a single session at the time of partial mastectomy. In up to 10% of patients, planned IORT is not completed; this leads to wasted resources and decreased patient satisfaction. Our objective was to evaluate factors associated with failure to complete planned IORT. METHODS AND MATERIALS: An IRB-approved review of planned IORT cases from 2011 to 2015 was conducted...
November 11, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27858093/targeted-intraoperative-radiotherapy-tumour-bed-boost-during-breast-conserving-surgery-after-neoadjuvant-chemotherapy
#5
Hans-Christian Kolberg, Gyoergy Loevey, Leyla Akpolat-Basci, Miltiades Stephanou, Peter A Fasching, Michael Untch, Cornelia Liedtke, Max Bulsara, Jayant S Vaidya
INTRODUCTION: The use of targeted intraoperative radiotherapy (TARGIT-IORT) as a tumour bed boost during breast-conserving surgery (BCS) for breast cancer has been reported since 1998. We present its use in patients undergoing breast conservation following neoadjuvant therapy (NACT). METHOD: In this retrospective study involving 116 patients after NACT we compared outcomes of 61 patients who received a tumour bed boost with IORT during lumpectomy versus 55 patients treated in the previous 13 months with external (EBRT) boost...
November 17, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27853900/risk-factors-leading-to-complications-in-early-stage-breast-cancer-following-breast-conserving-surgery-and-intraoperative-radiotherapy
#6
Sunpreet Rakhra, Kevin Bethke, Jonathan Strauss, John P Hayes, Nora Hansen, Seema A Khan, Irene Helenowski, Eric D Donnelly
OBJECTIVE: The aim of this study was to evaluate outcomes after breast-conserving surgery (BCS) and intraoperative radiotherapy (IORT), and to identify risk factors associated with complications. MATERIALS/METHODS: We evaluated patients with early-stage breast cancer treated from January 1, 2011 to January 31, 2014 with BCS and IORT at a single institution. The presence of breast cancer recurrences, complications, or fat necrosis were assessed at subsequent follow-up visits using physical examination and breast imaging...
November 16, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27846840/exclusive-intraoperative-radiotherapy-for-invasive-breast-cancer-in-elderly-patients-70%C3%A2-years-proportion-of-eligible-patients-and-local-recurrence-free-survival
#7
Eric Lambaudie, Gilles Houvenaeghel, Amira Ziouèche, Sophie Knight, François Dravet, Jean Remy Garbay, Sylvie Giard, Hélène Charitansky, Monique Cohen, Christelle Faure, Delphine Hudry, Paul Azuar, Richard Villet, Pierre Gimbergues, Christine Tunon de Lara, Agnès Tallet, Marie Bannier, Mathieu Minsat, Michel Resbeut
BACKGROUND: To estimate the proportion of elderly patients (>70 years) with breast cancer eligible for an Exclusive IntraOperative RadioTherapy (E-IORT) and to evaluate their local recurrence-free survival rate. METHODS: This retrospective study examining two cohorts focuses on patients over 70 years old: a multi-centric cohort of 1411 elderly patients and a mono-centric cohort of 592 elderly patients. All patients underwent conservative surgery followed by external radiotherapy for T0-T3 N0-N1 invasive breast cancer, between 1980 and 2008...
November 15, 2016: BMC Surgery
https://www.readbyqxmd.com/read/27816540/frequency-of-whole-breast-radiation-therapy-after-intraoperative-radiation-therapy-due-to-criteria-identified-by-lumpectomy
#8
Eric A Mellon, Amber Orman, Luis E Joya, Michael E Montejo, Christine Laronga, Susan J Hoover, M Catherine Lee, Nazanin Khakpour, Pamela F Kubal, Roberto Diaz
PURPOSE: For selected early breast cancers, intraoperative radiation therapy (IORT) at the time of lumpectomy can be an efficient alternative to fractionated whole breast radiation therapy (WBRT). However, some patients are later recommended WBRT after IORT due to surgical pathologic findings. To understand risk factor identification rates triggering WBRT recommendation, we analyzed adverse prognostic features based on multiple international criteria for suitability for accelerated partial breast irradiation...
November 2, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27807777/micro-invasive-surgery-combined-with-intraoperative-radiotherapy-for-the-treatment-of-spinal-metastasis
#9
Keng Chen, Lin Huang, Zhaopeng Cai, Juntian Shi, Kaiyun You, Huiyong Shen
PURPOSE: This is a retrospective analysis of the strategy and clinical results of surgery combined with intraoperative radiotherapy (IORT) to treat spinal metastases. METHODS: We delivered tumour-conformal IORT in 40 patients with 52 metastatic vertebrae based on our surgical classification system. The strategies were evaluated with respect to neurologic function and spinal stability. The EORTC QLQ-BM22, visual analogue scale (VAS) and the Frankel Scale were used to assess quality of life, pain and neurologic function...
November 2, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27807504/the-role-of-radiotherapy-in-the-management-of-localized-soft-tissue-sarcomas
#10
Siaw Sze Tiong, Colleen Dickie, Rick L Haas, Brian O'Sullivan
The combination of radiotherapy (RT) and function-preserving surgery is the most usual contemporary approach in the management of soft tissue sarcomas (STS). Pre- and postoperative RT result in similar local control rates, as shown by a landmark trial in extremity STS. In this review, the role of RT in the management of extremity STS will be discussed, but STS in other sites, including retroperitoneal STS, will also be addressed. The focus will consider various aspects of RT including strategies to reduce the volume of tissue being irradiated, dose, scheduling, and the possible of omission of RT in selected cases...
September 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27789182/current-role-of-radiotherapy-for-renal-cell-carcinoma-review
#11
REVIEW
Natalia Dengina, Ilya Tsimafeyeu, Timur Mitin
Surgery is the standard of care for patients with renal-cell carcinoma (RCC). Radiotherapy (RT) can decrease the risk of local recurrence after surgery and can lead to excellent outcomes in patients unfit for surgery. We reviewed clinical experience with various forms of RT, including conventional fractionated RT and intraoperative radiotherapy (IORT) as adjunct to surgery, hypofractionated high-dose stereotactic body radiotherapy (SBRT), and particle therapy in unresectable RCC. We discuss future directions for using RT in the treatment of RCC...
September 19, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27780674/effects-of-shielding-on-pelvic-and-abdominal-iort-dose-distributions
#12
Alessandro Esposito, Taxiarchis Sakellaris, Patrícia Limede, Filipa Costa, Luis T Cunha, Anabela Gregório Dias, Joana Lencart, Sandra Sarmento, Carla Carmelo Rosa
PURPOSE: To study the impact of shielding elements in the proximity of Intra-Operative Radiation Therapy (IORT) irradiation fields, and to generate graphical and quantitative information to assist radiation oncologists in the design of optimal shielding during pelvic and abdominal IORT. METHOD: An IORT system was modeled with BEAMnrc and EGS++ Monte Carlo codes. The model was validated in reference conditions by gamma index analysis against an experimental data set of different beam energies, applicator diameters, and bevel angles...
November 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27747042/patient-selection-for-partial-breast-irradiation-by-intraoperative-radiation-therapy-can-magnetic-resonance-imaging-be-useful-perspective-from-radiation-oncology-point-of-view
#13
Marco Krengli, Carla Pisani, Letizia Deantonio
The guidelines of the European and American Societies of Radiation Oncology (GEC-ESTRO and ASTRO) defined the selection criteria to offer partial breast irradiation (PBI) after lumpectomy in patients with low risk breast cancer regardless pre-operative staging. A recent publication by Tallet et al. explored the impact of preoperative magnetic resonance imaging (MRI) on patient eligibility for PBI. From their study, an ipsilateral BC was detected in 4% of patients, excluding these patients from intraoperative radiotherapy (IORT)...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27740973/intraoperative-radiotherapy-in-the-era-of-intensive-neoadjuvant-chemotherapy-and-chemoradiotherapy-for-pancreatic-adenocarcinoma
#14
Florence K Keane, Jennifer Y Wo, Cristina R Ferrone, Jeffrey W Clark, Lawrence S Blaszkowsky, Jill N Allen, Eunice L Kwak, David P Ryan, Keith D Lillemoe, Carlos Fernandez-Del Castillo, Theodore S Hong
OBJECTIVES: Improved outcomes with FOLFIRINOX or gemcitabine with nab-paclitaxel in the treatment of metastatic pancreatic adenocarcinoma (PDAC) have prompted incorporation of these regimens into neoadjuvant treatment of locally advanced unresectable PDAC. Whereas some patients remain unresectable on surgical exploration, others are able to undergo resection after intensive neoadjuvant treatment. We evaluated outcomes and toxicity associated with use of intensive neoadjuvant treatment followed by intraoperative radiotherapy (IORT) in combination with resection or exploratory laparotomy...
October 12, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27701375/intraoperative-radiotherapy-in-gastric-and-esophageal-cancer-meta-analysis-of-long-term-outcomes-and-complications
#15
Peng Gao, Chengche Tsai, Yuchong Yang, Yingying Xu, Changwang Zhang, Cong Zhang, Longyi Wang, Hongpeng Liu, Zhenning Wang
BACKGROUND: The treatment effects of intraoperative radiotherapy (IORT) for gastric and esophageal cancer remain uncertain. We therefore performed meta-analyses to investigate whether IORT was associated with more favorable oncologic outcomes when compared to non-IORT for patients who have gastric or esophageal cancer. METHODS: PubMed, Embase, and the references of relevant studies were systematically searched up to March 2016. Outcomes were analyzed with fixed-effect or random-effect models, and the meta-analysis was completed with odds ratio (OR), hazards ratio (HR), and 95% confidence intervals (CI) as effect values...
October 4, 2016: Minerva Medica
https://www.readbyqxmd.com/read/27675467/first-outcome-analysis-of-the-targit-e-lderly-trial-prospective-phase-2-study-of-intraoperative-radiation-therapy-iort-in-elderly-patients-with-small-breast-cancer
#16
F Wenz
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675314/initial-results-of-a-phase-1-2-trial-on-intraoperative-radiation-therapy-iort-in-newly-diagnosed-glioblastoma-multiforme-intrago
#17
F A Giordano, S Brehmer, B Muerle, G Welzel, E Sperk, F Schneider, S Clausen, P Schmiedek, C Groden, D Hänggi, Y Abo-Madyan, F Wenz
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674587/the-evaluation-of-tolerance-and-efficacy-of-intraoperative-radiation-therapy-iort-combined-with-external-beam-radiation-therapy-ebrt-in-patients-with-breast-cancer-after-breast-conserving-surgery-bct
#18
A Celejewska, J Wydmanski, W Majewski, G Wozniak, Z Kaniewska-Dorsz
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27673934/intraoperative-iort-versus-whole-breast-radiation-therapy-wbrt-for-early-breast-cancer-single-center-results-from-the-randomized-phase-3-targit-a-trial
#19
Y Abo-Madyan, G Welzel, E Sperk, C Neumaier, A Keller, S Clausen, F Schneider, M Ehmann, F Wenz
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27673827/risk-factors-for-breast-cancer-recurrence-after-intraoperative-radiation-therapy-iort
#20
E Sperk, P C Teich, C Weiß, M Sütterlin, F Wenz
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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