Ting Jin, Liping Yang, Chao Chang, Haojun Luo, Rui Wang, Yubi Gan, Yan Sun, Yuetong Guo, Rui Tang, Shanchun Chen, Die Meng, Peijin Dai, Manran Liu
Regulating nuclear export precisely is essential for maintaining mRNA homeostasis and impacts tumor progression. However, the mechanisms governing nuclear mRNA export remain poorly elucidated. Herein, it is revealed that the enhanced hypoxic long no-ncoding RNA (lncRNA prostate cancer associated transcript 6 (PCAT6) in breast cancer (BC) promotes the nuclear export of m6A-modified mRNAs, bolstering breast cancer stem cells (BCSCs) stemness and doxorubicin resistance. Clinically, hypoxic PCAT6 correlates with malignant BC features and poor prognosis...
April 16, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)