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https://www.readbyqxmd.com/read/29332254/comparison-of-adjustable-continence-therapy-periurethral-balloons-and-artificial-urinary-sphincter-in-female-patients-with-stress-urinary-incontinence-due-to-intrinsic-sphincter-deficiency
#1
Lucas Freton, Lauranne Tondut, Isabelle Enderle, Juliette Hascoet, Andrea Manunta, Benoit Peyronnet
INTRODUCTION AND HYPOTHESIS: The objective was to compare the outcomes of the ACT® device with those of the artificial urinary sphincter (AUS) AMS 800 in the treatment of stress urinary incontinence (SUI) due to sphincter deficiency in women. METHODS: All the women who underwent surgical treatment for SUI due to intrinsic sphincter deficiency from 2007 to 2017 were included in a single-center retrospective study. The primary endpoint was the functional outcome...
January 13, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29332240/preperitoneal-closed-system-suction-drainage-after-totally-extraperitoneal-hernioplasty-in-the-prevention-of-early-seroma-formation-a-prospective-double-blind-randomised-controlled-trial
#2
J K M Fan, J Liu, K Chen, X Yang, X Xu, H K Choi, F S Y Chan, K W H Chiu, C M Lo
OBJECTIVES: Seroma is a virtually unavoidable early sequela after TEP hernioplasty. This randomised controlled trial evaluated the outcomes of preperitoneal closed-system suction drainage in laparoscopic totally extraperitoneal (TEP) hernioplasty for inguinal hernia. METHODS: Ninety patients aged 18-80 years who presented to our hospital between May 2016 and February 2017 with primary unilateral inguinal hernia were randomised into the preperitoneal drain and no-drain groups...
January 13, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29332035/an-aspartyl-cathepsin-targeted-pet-agent-application-in-an-alzheimer-s-disease-mouse-model
#3
Jonatan A Snir, Mojmir Suchy, Geron A Bindseil, Michael Kovacs, Blaine A Chronik, Robert H E Hudson, Stephen H Pasternak, Robert Bartha
BACKGROUND: Early detection of Alzheimer's disease (AD) pathology is a serious challenge for both diagnosis and clinical trials. The aspartyl protease, Cathepsin D (CatD), is overexpressed in AD and could be a biomarker of disease. We have previously designed a unique contrast agent (CA) for dual-optical and magnetic resonance imaging of the activity of the CatD class of enzymes. OBJECTIVE: To compare the uptake and retention of a novel, more sensitive, and clinically-translatable 68Ga PET tracer targeting CatD activity in 5XFAD mice and non-Tg littermates...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29331927/honeycomb-like-polysulphone-polyurethane-nanofiber-filter-for-the-removal-of-organic-inorganic-species-from-air-streams
#4
Xin Chen, Yang Xu, Meimei Liang, Qinfei Ke, Yuanyuan Fang, He Xu, Xiangyu Jin, Chen Huang
Nanofiber nonwoven filters, especially those prepared by electrospinning, are of particular interest because of their high filtration efficiency. However, existing electrospun filters suffer from inherent limitations in that both strengths and filtration resistances of the filters leave much to be desired. Herein, we present a novel nonwoven filter that is composed of polysulphone and polyurethane nanofibers. By mimicking the honeycomb structure, a heterogeneous distribution of both fiber diameter and fiber density has been achieved...
January 8, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29331894/pharmaceutical-concentration-variability-at-sewage-treatment-plant-outlets-dominated-by-hydrology-and-other-factors
#5
Andrea F Brunsch, Thomas L Ter Laak, Huub Rijnaarts, Ekkehard Christoffels
A study was conducted in which the effluent at four small to medium sized sewage treatment plants (STP) in North Rhine-Westphalia, Germany was monitored for three pharmaceutical compounds (carbamazepine, diclofenac, metoprolol) over a period of four years. Grab sampling and auto sampling campaigns were accomplished with respect to various weather conditions in the catchment area. Flow volumes and hydraulic retention times (HRT) from various sampling dates which provide information on processes causing emission changes were additionally taken into account...
January 11, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29331859/development-of-a-method-to-determine-axitinib-lapatinib-and-afatinib-in-plasma-by-micellar-liquid-chromatography-and-validation-by-the-european-medicines-agency-guidelines
#6
Jaume Albiol-Chiva, Josep Esteve-Romero, Juan Peris-Vicente
A method based on micellar liquid chromatography to quantify the tyrosine kinase inhibitors axitinib, lapatinib and afatinib in plasma is reported. The sample pretreatment was a simple 1/5-dilution in a pure micellar solution, filtration and direct injection, without requiring extraction or purification steps. The three drugs were resolved from the matrix in 17min, using an aqueous solution of 0.07M sodium dodecyl sulfate - 6.0% 1-pentanol, buffered at pH7 with 0.01M phosphate salt as mobile phase, running under isocratic mode at 1mL/min through a C18 column...
January 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29331727/individual-variation-in-working-memory-is-associated-with-fear-extinction-performance
#7
Daniel M Stout, Dean T Acheson, Tyler M Moore, Ruben C Gur, Dewleen G Baker, Mark A Geyer, Victoria B Risbrough
PTSD has been associated consistently with abnormalities in fear acquisition and extinction learning and retention. Fear acquisition refers to learning to discriminate between threat and safety cues. Extinction learning reflects the formation of a new inhibitory-memory that competes with a previously learned threat-related memory. Adjudicating the competition between threat memory and the new inhibitory memory during extinction may rely, in part, on cognitive processes such as working memory (WM). Despite significant shared neural circuits and signaling pathways the relationship between WM, fear acquisition, and extinction is poorly understood...
January 5, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29331692/memory-performance-predicts-response-to-psychotherapy-for-depression-in-bipolar-disorder-a-pilot-randomized-controlled-trial-with-exploratory-functional-magnetic-resonance-imaging
#8
Thilo Deckersbach, Amy T Peters, Conor Shea, Aishwarya Gosai, Jonathan P Stange, Andrew D Peckham, Kristen K Ellard, Michael W Otto, Scott L Rauch, Darin D Dougherty, Andrew A Nierenberg
OBJECTIVE: This pilot randomized controlled trial compared Cognitive Behavior Therapy (CBT) and Supportive Psychotherapy (SP) for the treatment of depression in bipolar I disorder. We also examined whether exploratory verbal memory, executive functioning, and neural correlates of verbal memory during functional magnetic resonance imaging (fMRI) predicted change in depression severity. METHODS: Thirty-two adults (ages 18-65) with DSM-IV bipolar I disorder meeting current criteria for a major depressive episode were randomized to 18 weeks of CBT or SP...
December 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331506/hepatocyte-estrogen-receptor-alpha-mediates-estrogen-action-to-promote-reverse-cholesterol-transport-during-western-type-diet-feeding
#9
Lin Zhu, Jeanne Shi, Thao N Luu, Joshua C Neuman, Elijah Trefts, Sophia Yu, Brian T Palmisano, David H Wasserman, MacRae F Linton, John M Stafford
OBJECTIVE: Hepatocyte deletion of estrogen receptor alpha (LKO-ERα) worsens fatty liver, dyslipidemia, and insulin resistance in high-fat diet fed female mice. However, whether or not hepatocyte ERα regulates reverse cholesterol transport (RCT) in mice has not yet been reported. METHODS AND RESULTS: Using LKO-ERα mice and wild-type (WT) littermates fed a Western-type diet, we found that deletion of hepatocyte ERα impaired in vivo RCT measured by the removal of 3H-cholesterol from macrophages to the liver, and subsequently to feces, in female mice but not in male mice...
December 29, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29331225/influence-of-pressure-on-the-retention-of-resorcinarene-based-cavitands
#10
Ibolya Prauda, Endre Bartó, Attila Felinger
The thermodynamics of the retention mechanism of resorcinarene-based cavitands in RPLC as well as the nature of the binding sites have been studied recently. In the present study, the influence of pressure on the retention of the cyclic tetramers on alkylsilyl and polar-embedded C8 and C18 stationary phases is investigated using aqueous methanol mobile phase. The pressure effect for cavity-shaped molecules has been scarcely studied so far. We observed that the retention factors of the analytes increased with the increase of the average column pressure (1-400 bar) when using restricting capillary tubes...
January 9, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29331203/have-we-forgotten-about-forgetting-a-critical-review-of-accelerated-long-term-forgetting-in-temporal-lobe-epilepsy
#11
REVIEW
Anneli Cassel, Michael D Kopelman
Forgetting has been researched for over a century. This literature highlighted how forgetting rates can vary dependent on factors in the design and method. Recent interest in forgetting revived with evidence suggesting that seizures experienced almost immediately after matched learning could accelerate forgetting. This was followed by a growth in forgetting studies in patients with temporal lobe epilepsy (TLE), including a subset of those with transient epileptic amnesia (TEA). These patients have been described as expressing concerns about memory, yet often perform within 'normal' ranges on standard neuropsychological memory assessments...
December 26, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29331033/the-efficacy-and-safety-comparison-of-surgical-treatments-for-stress-urinary-incontinence-a-network-meta-analysis
#12
REVIEW
Pan Song, Yibo Wen, Chuiguo Huang, Wancong Wang, Naijun Yuan, Yinliang Lu, Qingwei Wang, Tao Zhang, Jianguo Wen
AIMS: Stress urinary incontinence (SUI) is a common problem worldwide. Mainstream surgical procedures include tension-free vaginal tape (TVT), transobturator tape (TOT), tension-free vaginal tape-obturator (TVT-O), tension-free vaginal tape SECUR (TVT-S), and adjustable single-incision sling (Ajust). The aim of this study was to compare the efficacy and safety of these surgical procedures and assess which surgery is most optimal for SUI by adopting a network meta-analysis (NMA). METHODS: Electronic databases including PubMed, Cochrance Library, and Embase database were researched systematically, until March 21, 2017...
January 13, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29330925/in-situ-growth-of-mno2-nanosheets-on-n-doped-carbon-nanotubes-derived-from-polypyrrole-tubes-for-supercapacitors
#13
Xu Ou, Qi Li, Dan Xu, Jiangna Guo, Feng Yan
Nitrogen-doped porous carbon nanotubes@MnO2 (N-CNTs@MnO2) nanocomposites are prepared through the in situ growth of MnO2 nanosheets on N-CNTs derived from polypyrrole nanotubes (PNTs). Benefiting from the synergistic effects between N-CNTs (high conductivity and N doping level) and MnO2 nanosheets (high theoretical capacity), the as-prepared N-CNTs@MnO2-800 nanocomposites show a specific capacitance of 219 F g-1 at a current density of 1.0 A g-1, which is higher than that of pure MnO2 nanosheets (128 F g-1) and PNTs (42 F g-1) in 0...
January 13, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29330778/isotopic-exchange-hplc-hrms-ms-applied-to-cyclic-proanthocyanidins-in-wine-and-cranberries
#14
Edoardo Longo, Fabrizio Rossetti, Matteo Scampicchio, Emanuele Boselli
Cyclic B-type proanthocyanidins in red wines and grapes have been discovered recently. However, proanthocyanidins of a different chemical structure (non-cyclic A-type proanthocyanidins) already known to be present in cranberries and wine possess an identical theoretical mass. As a matter of fact, the retention times and the MS/MS fragmentations found for the proposed novel cyclic B-type tetrameric proanthocyanidin in red wine and the known tetrameric proanthocyanidin in a cranberry extract are herein shown to be identical...
January 12, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29330590/a-meta-analysis-of-pesticide-loss-in-runoff-under-conventional-tillage-and-no-till-management
#15
Daniel Elias, Lixin Wang, Pierre-Andre Jacinthe
Global agricultural intensification has led to increased pesticide use (37-fold from 1960 to 2005) and soil erosion (14% since 2000). Conservation tillage, including no-till (NT), has been proposed as an alternative to conventional plow till (PT) to mitigate soil erosion, but past studies have reported mixed results on the effect of conservation tillage on pesticide loss. To explore the underlying factors of these differences, a meta-analysis was conducted using published data on pesticide concentration and load in agricultural runoff from NT and PT fields...
January 12, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29330354/the-res-complex-is-required-for-efficient-transformation-of-the-precatalytic-b-spliceosome-into-an-activated-bact-complex
#16
Penghui Bao, Cindy L Will, Henning Urlaub, Kum-Loong Boon, Reinhard Lührmann
The precise function of the trimeric retention and splicing (RES) complex in pre-mRNA splicing remains unclear. Here we dissected the role of RES during the assembly and activation of yeast spliceosomes. The efficiency of pre-mRNA splicing was significantly lower in the absence of the RES protein Snu17, and the recruitment of its binding partners, Pml1 (pre-mRNA leakage protein 1) and Bud13 (bud site selection protein 13), to the spliceosome was either abolished or substantially reduced. RES was not required for the assembly of spliceosomal B complexes, but its absence hindered efficient Bact complex formation...
January 12, 2018: Genes & Development
https://www.readbyqxmd.com/read/29330349/pharmacologic-inhibition-of-phospholipase-c-in-the-brain-attenuates-early-memory-formation-in-the-honeybee-apis-mellifera-l
#17
Shota Suenami, Shiori Iino, Takeo Kubo
Although the molecular mechanisms involved in learning and memory in insects have been studied intensively, the intracellular signaling mechanisms involved in early memory formation are not fully understood. We previously demonstrated that phospholipase C epsilon (PLCe), whose product is involved in calcium signaling, is almost selectively expressed in the mushroom bodies, a brain structure important for learning and memory in the honeybee. Here, we pharmacologically examined the role of phospholipase C (PLC) in learning and memory in the honeybee...
January 12, 2018: Biology Open
https://www.readbyqxmd.com/read/29330316/myosin-1c-uses-a-novel-phosphoinositide-dependent-pathway-for-nuclear-localization
#18
Ilja Nevzorov, Ekaterina Sidorenko, Weihuan Wang, Hongxia Zhao, Maria K Vartiainen
Accurate control of macromolecule transport between nucleus and cytoplasm underlines several essential biological processes, including gene expression. According to the canonical model, nuclear import of soluble proteins is based on nuclear localization signals and transport factors. We challenge this view by showing that nuclear localization of the actin-dependent motor protein Myosin-1C (Myo1C) resembles the diffusion-retention mechanism utilized by inner nuclear membrane proteins. We show that Myo1C constantly shuttles in and out of the nucleus and that its nuclear localization does not require soluble factors, but is dependent on phosphoinositide binding...
January 12, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29330304/efficient-prion-disease-transmission-through-common-environmental-materials
#19
Sandra Pritzkow, Rodrigo Morales, Adam Lyon, Luis Concha-Marambio, Akihiko Urayama, Claudio Soto
Prion diseases are a group of fatal neurodegenerative diseases associated with a protein-based infectious agent, termed prion. Compelling evidence suggests that natural transmission of prion diseases is mediated by environmental contamination with infectious prions. We hypothesized that several natural and man-made materials, commonly found in the environments of wild and captive animals, can bind prions and may act as vectors for disease transmission. To test our hypothesis, we exposed surfaces composed of various common environmental materials (i...
January 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29330282/population-dependent-intron-retention-and-dna-methylation-in-breast-cancer
#20
Dongwook Kim, Manu Shivakumar, Seonggyun Han, Michael S Sinclair, Youngji Lee, Yonglan Zheng, Olufunmilayo I Olopade, Dokyoon Kim, Younghee Lee
Regulation of gene expression by DNA methylation in gene promoter regions is well-studied; however, the effects of methylation in the gene body (exons and introns) on gene expression are comparatively understudied. Recently, hyper-methylation has been implicated in the inclusion of alternatively spliced exons; moreover, exon recognition can be enhanced by recruiting the methyl-CpG-binding protein (MeCP2) to hyper-methylated sites. This study examines if methylation status of an intron is correlated with how frequently the intron is retained during splicing using DNA methylation and RNA sequencing (RNA-seq) data from breast cancer tissue specimens in The Cancer Genome Atlas (TCGA)...
January 12, 2018: Molecular Cancer Research: MCR
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