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https://www.readbyqxmd.com/read/27070592/distinct-dasatinib-induced-mechanisms-of-apoptotic-response-and-exosome-release-in-imatinib-resistant-human-chronic-myeloid-leukemia-cells
#1
Juan Liu, Yujing Zhang, Aichun Liu, Jinghua Wang, Lianqiao Li, Xi Chen, Xinyu Gao, Yanming Xue, Xiaomin Zhang, Yao Liu
Although dasatinib is effective in most imatinib mesylate (IMT)-resistant chronic myeloid leukemia (CML) patients, the underlying mechanism of its effectiveness in eliminating imatinib-resistant cells is only partially understood. This study investigated the effects of dasatinib on signaling mechanisms driving-resistance in imatinib-resistant CML cell line K562 (K562R(IMT)). Compared with K562 control cells, exsomal release, the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/ mammalian target of rapamycin (mTOR) signaling and autophagic activity were increased significantly in K562R(IMT) cells and mTOR-independent beclin-1/Vps34 signaling was shown to be involved in exosomal release in these cells...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/25712828/a-case-with-neonatal-hyperinsulinemic-hypoglycemia-it-is-a-characteristic-complication-of-sotos-syndrome
#2
Yoshie Nakamura, Masaki Takagi, Hiroshi Yoshihashi, Masaru Miura, Satoshi Narumi, Tomonobu Hasegawa, Yoshishige Miyake, Yukihiro Hasegawa
Sotos syndrome (SoS, OMIM #117550) is an overgrowth syndrome. Deletions or intragenic mutations of the NSD1 , which is located at chromosome 5q35, are responsible for more than 75% of SoS. Conventionally, neonatal hypoglycemia was reported briefly as one of the infrequent symptoms of SoS. However, Matsuo et al. published a report describing five patients with SoS who presented with transient hyperinsulinemic hypoglycemia (HIH) in the neonatal period. We report on an additional patient of SoS, who presented transient HIH in the neonatal period...
May 2015: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/24459776/-national-consensus-of-diagnosis-and-treatment-of-non-small-cell-lung-cancer
#3
Oscar Arrieta, Enrique Guzmán-de Alba, Luis Felipe Alba-López, Alicia Acosta-Espinoza, Jorge Alatorre-Alexander, José Francisco Alexander-Meza, Silvia Rosa Allende-Pérez, Salvador Alvarado-Aguilar, Margarita E Araujo-Navarrete, Luis Marcelo Argote-Greene, Cinthia Alejandra Aquino-Mendoza, Alma Magdalena Astorga-Ramos, Horacio Austudillo-de la Vega, Alejandro Avilés-Salas, Luis Javier Barajas-Figueroa, Nimbe Barroso-Quiroga, Mónica Blake-Cerda, Paula Anel Cabrera-Galeana, Germán Calderillo-Ruíz, Alma Delia Campos-Parra, Ana María Cano-Valdez, Daniel Capdeville-García, Graciano Castillo-Ortega, Catalina Casillas-Suárez, Patricia Castillo-González, José Francisco Corona-Cruz, María Elma Correa-Acevedo, Séfora Sonciry Cortez-Ramírez, Jhony Alberto de la Cruz-Vargas, Jaime G de la Garza-Salazar, María Dolores de la Mata-Moya, María Eugenia Domínguez-Flores, Hugo Ricardo Domínguez-Malagón, Luis Manuel Domínguez-Parra, Alfredo Domínguez-Peregrina, Jaime Durán-Alcocer, María Isabel Enríquez-Aceves, Abelardo Elizondo-Ríos, Moisés Dante Escobedo-Sánchez, Pablo Espinosa-Mireles de Villafranca, Alberto Flores-Cantisani, Juan Pablo Flores-Gutiérrez, Francisco Franco-Marina, Edwin Efraín Franco-González, Ramón Antonio Franco-Topete, Homero Fuentes-de la Peña, Susana Galicia-Amor, Dolores Gallardo-Rincón, Armando Gamboa-Domínguez, Jorge García-Andreu, Claudia María García-Cuéllar, María Cecilia García-Sancho-Figueroa, Rogelio García-Torrentera, Raquel Gerson-Cwilich, Arturo Gómez-González, León Green-Schneeweiss, María del Rocío Guillén-Núñez, Hilda Gutiérrez-Velázquez, Carlos Ibarra-Pérez, Edgardo Jiménez-Fuentes, Paula Juárez-Sánchez, Alejandro Juárez-Ramiro, Javier Kelly-García, Roberto Kuri-Exsome, Jesús Miguel Lázaro-León, Eucario León-Rodríguez, Sara Llanos-Osuna, Sara Llanos-Osuna, Ulises Loyola-García, José Sullivan López-González, Francisco Javier López y de Antuñano, Marco Antonio Loustaunau-Andrade, Eleazar Omar Macedo-Pérez, Limberth Machado-Villarroel, Manuel Magallanes-Maciel, Luis Martínez-Barrera, Jorge Martínez-Cedillo, Gloria Martínez-Martínez, Alfredo Medina-Esparza, Abelardo Meneses-García, Alejandro Mohar-Betancourt, Jaime Morales Blanhir, José Morales-Gómez, Daniel Motola-Kuba, Marcela Patricia Nájera-Cruz, Carolina del Carmen Núñez-Valencia, María Angélica Ocampo-Ocampo, María Dolores Ochoa-Vázquez, Carlos A Olivares-Torres, Andrés Palomar-Lever, Mario Patiño-Zarco, Rogelio Pérez-Padilla, Yolanda Rocío Peña-Alonso, Alfredo Rafael Pérez-Romo, Mario Aquilino Pérez, Paulo Martín Pinaya-Ruíz, María Adela Pointevin-Chacón, Juan José Poot-Braga, Rodolfo Posadas-Valay, Marcelino Ramirez-Márquez, Ivonne Reyes-Martínez, Julio Robledo-Pascual, Jerónimo Rodríguez-Cid, Carlos Enrique Rojas-Marín, Elizabeth Romero-Bielma, Jaime Ernesto Rubio-Gutiérrez, Julia Angelina Sáenz-Frías, Miguel Angel Salazar-Lezama, Karla Sánchez-Lara, Raúl Sansores Martínez, Patricio Santillán-Doherty, Juan Alejandro-Silva, José Luis Téllez-Becerra, Vinicio Toledo-Buenrostro, Luis Torre-Bouscoulet, Laura Torecillas-Torres, Marineé Torres, Víctor Tovar-Guzmán, Jenny Georgina Turcott-Chaparro, Jesús Javier Vázquez-Cortés, María Eugenia Vázquez-Manríquez, Natalia Vilches-Cisneros, José Felipe Villegas-Elizondo, Mauro M Zamboni, Jesús Zamora-Moreno, Juan W Zinser-Sierra
Mexican specialists in oncology, oncologic surgery, thoracic surgery, pneumology, pathology, molecular biology, anesthesiology, algology, psychology, nutrition, and rehabilitation (all of them experts in lung cancer treatment) in order to develop the National Consensus on Lung Cancer. The consensus has been developed as an answer to the need of updated Mexican guidelines for the optimal treatment of the disease, as well as to the requirements that such guidelines be established by multidisciplinary panel, depicting the current attention given to cancer lung cases in Mexico...
March 2013: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/21416918/-the-first-mexican-consensus-of-endometrial-cancer-grupo-de-investigaci%C3%A3-n-en-c%C3%A3-ncer-de-ovario-y-tumores-ginecol%C3%A3-gicos-de-m%C3%A3-xico
#4
Eva Ruvalcaba-Limón, David Cantú-de-León, Eucario León-Rodríguez, Patricia Cortés-Esteban, Alberto Serrano-Olvera, Flavia Morales-Vásquez, Ricardo Sosa-Sánchez, Andrés Poveda-Velasco, Alejandro Crismatt-Zapata, Antonio Santillán-Gómez, Carmen Aguilar-Jiménez, Patricia Alanís-López, Paulino Alfaro-Ramírez, Miguel Angel Alvarez-Avitia, Carlos Eduardo Aranda-Flores, José Héctor Reynaldo Arias-Ceballos, Oscar Arrieta-Rodríguez, Eduardo Barragán-Curiel, Daniel Botello-Hernández, Rocío Brom-Valladares, Paula Anel Cabrera-Galeana, Juan Carlos Cantón-Romero, Daniel Capdeville-García, Jesús Cárdenas-Sánchez, Gerardo Castorena-Roji, Friedman Rafael Cepeda-López, Guadalupe Cervantes-Sánchez, Lucely de Carmen Cetina-Pérez, Jaime Alberto Coronel-Martínez, Seir Alfonso Cortés-Cárdenas, Juan Carlos Cruz-López, Jaime G de la Garza-Salazar, Consuelo Díaz-Romero, Alfonso Dueñas-González, Aura Erazo Valle-Solís, Pedro Escudero-de los Ríos, Efrén Flores-Alvarez, Rolando García-Matus, Raquel Gerson-Cwilich, Aarón González-Enciso, César González-de-León, Alfonso Genaro Guevara-Torres, Guillermo Sidney Herbert-Núñez, Carlos Hernández-Hernández, Dulce María Hernández-Hernández, David Isla-Ortiz, Ramiro Jesús-Sandoval, Carlos Jiménez-Cervantes, Roberto Kuri-Exsome, José Luis López-Obispo, Antonio Maffuz-Aziz, Luis Manuel Martínez-Barrera, Juan Manuel Medina-Castro, Gonzalo Montalvo-Esquivel, Víctor Hugo Mora-Aguilar, Miguel Angel Morales-Palomares, Andrés Morán-Mendoza, Gilberto Morgan-Villela, Aída Mota-García, David Eduardo Muñoz-González, Dino Alberto Murillo-Cruz, Arturo Novoa-Vargas, Francisco J Ochoa-Carrillo, Luis Fernando Oñate-Ocaña, Andrea Ortega-Rojo, Alma Georgina Palacios-Martínez, Antonio Palomeque-López, María Delia Pérez-Montiel, Félix Quijano-Castro, Samuel Rivera-Rivera, Lesbia María Rivera-Rubí, Juan Ubaldo Robles-Flores, Amelia Rodríguez-Trejo, Efraín Salas-Gonzáles, Juan Alejandro Silva, Gilberto Solorza-Luna, Rosalía Souto-del-Bosque, Laura Leticia Tirado-Gómez, Salvador Torrescano-González, Alfonso Torres-Lobatón, Elizabeth Trejo-Durán, Verónica Villavicencio-Valencia, Dolores Gallardo-Rincón
INTRODUCTION: Endometrial cancer (EC) is the second most common gynecologic malignancy worldwide in the peri and postmenopausal period. Most often for the endometrioid variety. In early clinical stages long-term survival is greater than 80%, while in advanced stages it is less than 50%. In our country there is not a standard management between institutions. GICOM collaborative group under the auspice of different institutions have made the following consensus in order to make recommendations for the management of patients with this type of neoplasm...
November 2010: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/20676898/preliminary-data-on-the-association-between-waist-circumference-and-insulin-resistance-in-children-without-a-previous-diagnosis
#5
MULTICENTER STUDY
Elena Rodríguez-Rodríguez, Carolina Palmeros-Exsome, Ana M López-Sobaler, Rosa M Ortega et al.
The aim of the present work was to study the association between different anthropometric parameters and insulin resistance (IR) in Spanish schoolchildren without a previous diagnosis. A total of 443 Spanish schoolchildren (9-11 years of age) were studied in this cross-sectional study. The anthropometric measurements collected were weight, height, body circumferences and skinfolds. Body mass index (BMI), waist/hip ratio, percentage body fat and fat-free body mass were determined. Overnight-fasted blood lipids, insulin and glucose levels were analysed, and estimation of IR, taking into account the homeostasis model assessment (HOMA), was calculated...
January 2011: European Journal of Pediatrics
https://www.readbyqxmd.com/read/18093476/-metabolic-syndrome-prevalence-and-its-association-with-the-body-mass-index-in-university-students
#6
Enrique González Deschamps, Carolina Palmeros Exsome, Javier Villanueva Sánchez, Beatriz Torres Flores, Sara Bastida, M Pilar Vaquero, Francisco J Sánchez-Muniz
BACKGROUND AND OBJECTIVE: Few studies exist about metabolic syndrome (MS) in young Mexican adult populations. The prevalences of overweight, obesity, and MS were evaluated in a sample of university students from Veracruz, México. SUBJECTS AND METHOD: Transversal analytical study performed in 402 student of new admission, aged 20-29 years belonging to Veracruzana University. Waist circumference, systolic and diastolic blood pressures, and serum glucose, triglycerides, and high-density lipoproteins (HDL)-cholesterol were determined...
December 1, 2007: Medicina Clínica
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