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Endometrial stromal sarcoma

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https://www.readbyqxmd.com/read/29275929/endometrial-stromal-sarcomas-and-related-neoplasms-new-developments-and-diagnostic-considerations
#1
REVIEW
Lien Hoang, Sarah Chiang, Cheng-Han Lee
Our understanding of endometrial stromal sarcomas has evolved dramatically since their earliest descriptions from over a century ago. Initial studies focused on establishing the relationship between histological appearances of endometrial stromal sarcomas and their clinical outcomes. Studies performed in the last decade have uncovered several recurrent cytogenetic aberrations occurring in low- and high-grade endometrial stromal sarcomas. Low-grade endometrial stromal sarcomas bear close histopathological resemblance to proliferative-type endometrial stroma, and approximately half harbour t(7;17)(p15;q21) resulting in JAZF1-SUZ12 gene fusion...
December 21, 2017: Pathology
https://www.readbyqxmd.com/read/29245257/endometrial-stromal-sarcoma-in-combination-with-mixed-type-endometrial-carcinomas-a-case-report-and-literature-review
#2
REVIEW
Xiao-Xin Xiu, Hua-Li Wang, Lv Yun-Yi, Kong Fan-Dou, Hou Jin-Ping
RATIONALE: Endometrial stromal sarcoma (ESS) is rare, representing only approximately 0.2% of all uterine malignancies. Mixed type endometrial carcinomas (MT-ECs) are rare tumors with both type I and II features, and are difficult to diagnose. Cases of ESS and MT-ECs coexisting in the same patient are extremely rare. This study aimed to describe a case of ESS in combination with MT-ECs in a 47-year-old premenopausal woman. PATIENT CONCERNS: A woman presented to the hospital complaining of occasional abdominal pain and had high tumor markers: cancer antigen (CA) 19-9 (263...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29225247/hypercalcemia-after-the-discontinuation-of-medroxyprogesterone-acetate
#3
Erina Yuasa-Shibasaki, Sumiyasu Ishii, Shunichi Matsumoto, Takuya Tomaru, Kazuhiko Horiguchi, Aya Osaki, Atsushi Ozawa, Nobuyuki Shibusawa, Tetsurou Satoh, Masanobu Yamada
A 39-year-old woman was admitted to our hospital with symptoms of general fatigue, nausea, and vomiting that appeared three months after she stopped seven years of medroxyprogesterone acetate (MPA) medication for endometrial stromal sarcoma. Laboratory tests demonstrated moderate hypercalcemia. Several tests demonstrated that she was suffering from adrenal insufficiency. Glucocorticoid supplementation decreased her calcium level to a normal range, indicating that hypercalcemia was induced by adrenal insufficiency...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29218216/primary-low-grade-endometrial-stromal-sarcoma-arising-in-the-vagina-report-of-an-unusual-case-and-literature-review
#4
Ghada A Abu Jamea, Ammar C Al Rikabi, Khalid Akkour
Endometrial stromal sarcoma rarely occurs as an extrauterine neoplasm and it is even more unlikely to be found in the vagina. To the best of our knowledge, only six cases of primary vaginal endometrial stromal sarcoma without association with endometriosis have been published to this day. We describe a case of a 58-year-old female with a history of vaginal heaviness caused by a mass lesion. After a biopsy was taken, the histopathological findings and immunohistochemical stains were consistent with low-grade endometrial stromal sarcoma...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29210799/extrauterine-extragenital-endometrial-stromal-sarcoma-in-the-absence-of-endometriosis-a-rare-entity
#5
Pratibha S Shukla, Chris Schwartz
No abstract text is available yet for this article.
November 28, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29200103/bcor-internal-tandem-duplication-in-high-grade-uterine-sarcomas
#6
Adrián Mariño-Enriquez, Alexandra Lauria, Joanna Przybyl, Tony L Ng, Magdalena Kowalewska, Maria Debiec-Rychter, Raji Ganesan, Vaiyapuri Sumathi, Suzanne George, W Glenn McCluggage, Marisa R Nucci, Cheng-Han Lee, Jonathan A Fletcher
Endometrial stromal sarcomas (ESSs) are mesenchymal uterine tumors characterized by recurrent genetic events, most commonly chromosomal rearrangements, that create oncogenic gene fusions. High-grade endometrial stromal sarcomas (HG-ESSs), as defined in the 2014 World Health Organization Classification, typically contain oncogenic YWHAE-NUTM2 fusions; however, although not well characterized, there are tumors morphologically overlapping with HG-ESS that do not contain the YWHAE-NUTM2 fusions. These fusions are also found in certain pediatric primitive sarcomas, including clear cell sarcoma of the kidney and soft tissue undifferentiated round cell sarcoma of infancy...
December 1, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29197420/ovarian-mucinous-borderline-tumor-accompanied-by-lgess-with-myxoid-change-a-case-report-and-literature-review
#7
Wen Wang, Yalin Zhuang, Feng Zhou, Lili Huang
OBJECTIVES: To report an extremely rare case of ovarian borderline mucinous cystic tumor accompanied by low-grade endometrial stromal sarcoma (LGESS) with myxoid change. CASE PRESENTATION: A 42-year-old woman complained of lower left abdominal fullness. Her serum carcinoembryonic antigen, cancer antigen (CA) 125, and CA19-9 levels were normal. Magnetic resonance imaging showed a 10-cm cystic mass with a 5-cm nodule in its wall, and a laparoscopy indicated a cystic mass at the left adnexa...
December 2, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29192652/zc3h7b-bcor-high-grade-endometrial-stromal-sarcomas-a-report-of-17-cases-of-a-newly-defined-entity
#8
Natasha Lewis, Robert A Soslow, Deborah F Delair, Kay J Park, Rajmohan Murali, Travis J Hollmann, Ben Davidson, Francesca Micci, Ioannis Panagopoulos, Lien N Hoang, Javier A Arias-Stella, Esther Oliva, Robert H Young, Martee L Hensley, Mario M Leitao, Meera Hameed, Ryma Benayed, Marc Ladanyi, Denise Frosina, Achim A Jungbluth, Cristina R Antonescu, Sarah Chiang
High-grade endometrial stromal sarcoma likely encompasses underrecognized tumors harboring genetic abnormalities besides YWHAE-NUTM2 fusion. Triggered by three initial endometrial stromal sarcomas with ZC3H7B-BCOR fusion characterized by high-grade morphology and aggressive clinical behavior, we herein investigate the clinicopathologic features of this genetic subset by expanding the analysis to 17 such tumors. All of them occurred in adult women with a median age of 54 (range, 28-71) years. They were predominantly based in the endomyometrium and demonstrated tongue-like and/or pushing myometrial invasion...
December 1, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29185261/pazopanib-monotherapy-in-the-treatment-of-pretreated-metastatic-uterine-sarcoma-a-single-center-retrospective-study
#9
Hyun Jun Kim, Youjin Kim, Su Jin Lee, Jeeyun Lee, Se Hoon Park
OBJECTIVE: In the treatment of metastatic soft tissue sarcoma (STS), pazopanib is considered a standard treatment after failure of chemotherapy. We retrospectively investigated outcomes of pazopanib in patients with metastatic uterine STS. METHODS: A retrospective study was performed on 35 consecutive patients with uterine STS treated with oral pazopanib 800 mg daily as salvage therapy for metastatic disease between September 2013 and December 2015. Endpoints included response rate, survival, and safety...
January 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29136690/-values-of-jazf1-gene-rearrangement-detected-by-fluorescence-in-situ-hybridization-in-diagnosis-of-endometrial-stromal-tumours
#10
Q M Bai, B Chang, X Y Tu, R Bi, Y F Cheng, D Huang, X L Zhu, L J Wu, X Zhang, X Y Zhou, W T Yang
Objective: To investigate the role of JAZF1 gene rearrangement in the diagnosis and differential diagnosis of endometrial stromal sarcomas by fluorescence in situ hybridization (FISH). Methods: JAZF1 gene rearrangement was analyzed by FISH in 129 cases of ESS diagnosed from January 2008 to December 2016 including 105 cases of low-grade endometrial stromal sarcoma (LG-ESS), 21 cases of high-grade endometrial stromal sarcoma (HG-ESS) and 3 cases of undifferentiated uterine sarcoma (UUS). Sixteen cases of the related tumours in uterus were also collected as control group...
November 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29133752/proportion-of-uterine-malignant-tumors-in-patients-with-laparoscopic-myomectomy-a-national-multicenter-study-in-china
#11
Hua Yang, Xiao-Chuan Li, Chen Yao, Jing-He Lang, Hang-Mei Jin, Ming-Rong Xi, Gang Wang, Lu-Wen Wang, Min Hao, Yan Ding, Jie Chen, Jian-Qing Zhang, Lu Han, Cheng-Xiu Guo, Xiang Xue, Yan Li, Jian-Hua Zheng, Man-Hua Cui, Huai-Fang Li, Guang-Shi Tao, Long Chen, Su-Min Wang, An-Wei Lu, Ze-Hua Huang, Qing Liu, Ya-Li Zhuang, Xiang-Hua Huang, Gen-Hai Zhu, Ou-Ping Huang, Li-Na Hu, Mu-Jun Li, Hong-Lin Zhou, Jing-Hui Song, Lan Zhu
BACKGROUND: The Food and Drug Administration recently announced that the use of morcellation may cause fibroids or pelvic dissemination and metastasis of uterine sarcoma; therefore, the use of morcellation is limited in the USA. A large sample study is necessary to assess the proportion of uterine malignant tumors found in patients with laparoscopic myomectomy. METHODS: A national multicenter study was performed in China. From 2002 to 2014, 33,723 cases were retrospectively selected...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29040191/incidence-patterns-and-survival-of-gynecological-sarcoma-in-germany-analysis-of-population-based-cancer-registry-data-on-1066-women
#12
Klaus Pietzner, Nina Buttmann-Schweiger, Jalid Sehouli, Klaus Kraywinkel
OBJECTIVE: Sarcomas of the female genital tract are rare tumors. They are described to be associated with a poor prognosis when compared with gynecogical carcinoma. The aim of this study was to report incidence patterns and survival rates for gynecological sarcoma (GS) in Germany. METHODS/MATERIALS: Clinical data and survival rates for patients with GS diagnosed in Germany between 2009 and 2013 were extracted from the German national center for population-based cancer registry data...
October 17, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28982163/oncogenic-hrasg12v-expression-plus-knockdown-of-cdkn2a-using-ecotropic-lentiviral-vectors-induces-high-grade-endometrial-stromal-sarcoma
#13
Laura P Brandt, Joachim Albers, Tomas Hejhal, Antonella Catalano, Peter J Wild, Ian J Frew
The uterine corpus represents the most common site for tumour development in the female genital system. Uterine neoplasms are categorised as epithelial, mesenchymal, mixed epithelial-mesenchymal or trophoblastic tumours. In this study we employed a mouse genetic approach using the MuLE lentiviral gene regulatory system to functionally test the ability of ecotropic lentiviruses to model epithelial and mesenchymal uterine malignancies ex vivo and in vivo. We discovered that MuLE lentiviruses efficiently infect uterine stromal cells but not endometrial epithelial cells when injected into the uterus of cycling, pseudopregnant or ovarectomized mice...
2017: PloS One
https://www.readbyqxmd.com/read/28967566/multi-institutional-study-of-peritoneal-sarcomatosis-from-uterine-sarcoma-treated-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#14
Armando Sardi, Arkadii Sipok, Dario Baratti, Marcello Deraco, Paul Sugarbaker, George Salti, Yutaka Yonemura, Paolo Sammartino, Olivier Glehen, Naoual Bakrin, Teresa P Díaz-Montes, Vadim Gushchin
OBJECTIVE: Uterine sarcoma (US) is a rare tumor representing 1% of female genital tract malignancies. Peritoneal sarcomatosis (PS) after US, diminishes median overall survival (OS) and progression-free survival (PFS) with cytoreductive surgery (CRS) alone, with or without systemic chemotherapy is <1 year and 6 months, respectively. A multi-institutional review of PS from US was conducted to evaluate CRS and hyperthermic intraperitoneal chemotherapy (HIPEC) and effects on survival outcomes...
September 7, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28967156/cardiac-metastatic-endometrial-stromal-sarcoma-17-years-after-hysterectomy
#15
Valdano Manuel, Fabrício J Dinato, Paulo S Gutierrez, Sheila A C Siqueira, Fábio A Gaiotto, Fábio B Jatene
We report a 60-year-old female who underwent resection of an endometrial stromal sarcoma of the right ventricle 17 years following a hysterectomy and radiation therapy for the same tumor.
October 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28919822/uterine-sarcoma-current-perspectives
#16
REVIEW
Charlotte Benson, Aisha B Miah
Uterine sarcomas comprise a group of rare tumors with differing tumor biology, natural history and response to treatment. Diagnosis is often made following surgery for presumed benign disease. Currently, preoperative imaging does not reliably distinguish between benign leiomyomas and other malignant pathology. Uterine leiomyosarcoma is the most common sarcoma, but other subtypes include endometrial stromal sarcoma (low grade and high grade), undifferentiated uterine sarcoma and adenosarcoma. Clinical trials have shown no definite survival benefit of adjuvant radiotherapy or chemotherapy and have been hampered by the rarity and heterogeneity of these disease types...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28906310/endometrial-stromal-sarcoma-of-the-uterus-magnetic-resonance-imaging-findings-including-apparent-diffusion-coefficient-value-and-its-correlation-with-ki-67-expression
#17
Hai Ming Li, Jia Liu, Jin Wei Qiang, Wei Yong Gu, Guo Fu Zhang, Feng Hua Ma
OBJECTIVE: This study aimed to investigate the conventional magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) features of endometrial stromal sarcoma (ESS) including a preliminary investigation of the correlation between the apparent diffusion coefficient (ADC) value and Ki-67 expression. METHODS: The clinical and MRI data of 15 patients with ESS confirmed by surgery and pathology were analyzed retrospectively. The conventional MR morphological features, signal intensity on DWI, ADC value (n = 14), and clinicopathological marker Ki-67 (n = 13) were evaluated...
November 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28894063/-pneumothorax-caused-by-multiple-pulmonary-metastases-of-a-uterine-endometrial-stromal-sarcoma-report-of-a-case
#18
Shin Shomura, Hitoshi Suzuki, Masaki Yada, Chiaki Kondo
A 53-year-old woman who had undergone hystero-oophorectomy for uterine endometrial stromal sarcoma in our hospital 9 months previously was referred to our hospital because of bilateral pneumothorax. Chest computed tomography scan on admission revealed multiple thin-walled cavity nodules in both lung and a bilateral pneumothorax, suggesting pulmonary metastases of the uterine endometrial stromal sarcoma. We surgically treated the pneumothorax and diagnosed the nodules as metastatic lesions. They were pathologically diagnosed as metastatic uterine endometrial stromal sarcoma...
September 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28863072/ywhae-rearrangement-in-a-purely-conventional-low-grade-endometrial-stromal-sarcoma-that-transformed-over-time-to-high-grade-sarcoma-importance-of-molecular-testing
#19
Omonigho Aisagbonhi, Beth Harrison, Liena Zhao, Rebecca Osgood, Ivan Chebib, Esther Oliva
Low and high-grade endometrial stromal sarcomas (ESS) can be distinguished on a morphologic basis. Low-grade ESS is composed of oval cells that resemble normal proliferative-phase endometrial stroma, while the well-known high-grade ESS is composed of round cells growing in nests separated by delicate sinusoidal vasculature. Recurrent JAZF1 rearrangements have been reported to be most frequent in low-grade stromal sarcomas (up to 60%), while YWHAE rearrangements are characteristic of high-grade ESS. Herein, we report a case of a 45-yr-old woman with stage IA typical low-grade ESS who developed multiple abdominopelvic recurrences and lung metastases 15 mo after her primary tumor was resected...
August 31, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28862061/pulmonary-metastasis-of-undifferentiated-uterine-sarcoma-forming-fluid-containing-cyst
#20
Genki Usui, Hirotsugu Hashimoto, Jun Matsumoto, Masaaki Akahane, Hajime Tsunoda, Yuko Sasajima, Hajime Horiuchi
Undifferentiated uterine sarcoma (UUS) is a high-grade sarcoma with no specific differentiation; however, it exhibits variable positivity for CD10 as an immunohistochemical marker of endometrial stroma, suggesting immunohistochemical differentiation into endometrial stroma. It has been reported that some low-grade endometrial stromal sarcoma pulmonary metastatic foci show cystic changes; however, whether pulmonary metastatic UUS foci are solid or cystic remains undescribed. A 63-year-old woman underwent a hysterectomy...
August 1, 2017: International Journal of Surgical Pathology
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