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Endometrial stromal sarcoma

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https://www.readbyqxmd.com/read/28511398/undifferentiated-uterine-sarcoma-an-uncommon-case-report
#1
Madhumita Mukhopadhyay, Chhanda Das, Tamanna Parvin, Keya Basu
Endometrial Stromal Sarcomas (ESS) are rare uterine malignancy of mesodermal origin. A 65-year-old female presented with postmenopausal bleeding in the Department of Gynaecology in our hospital. Computed Topography (CT) revealed an enlarged uterus with areas of low attenuation. On gross appearance endometrial cavity was distorted with an irregular friable necrotic mass. Histopathologically, it was diagnosed as undifferentiated uterine sarcoma. Rhabdoid, osteoid and cartilaginous differentiation were found along with osteoclast like giant cells...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28498251/undiagnosed-uterine-sarcomas-identified-during-surgery-for-presumed-leiomyoma-at-a-national-tertiary-hospital-in-thailand-a-10-year-review
#2
Irene Ruengkhachorn, Nisarat Phithakwatchara, Katika Nawapun, Suchanan Hanamornroongruang
OBJECTIVES: The aim of this study was to evaluate the rate, clinical characteristics, and survival outcomes of an undiagnosed uterine malignancy in patients who underwent surgical treatment for presumed leiomyomas. METHODS: Medical records of patients who underwent surgical treatment for presumed leiomyomas, from January 2004 to September 2013, were retrospectively reviewed, and the data were followed until September 2016. Demographic data, tumor characteristics, oncologic treatment, and response rate were analyzed by descriptive statistics...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28494324/an-unexpected-diagnosis-of-primary-omental-endometrial-stromal-sarcoma-in-a-patient-with-acute-right-abdominal-pain-a-case-report-and-review-of-literature
#3
Vered Buchholz, George Kiroff, Markus Trochsler, Harsh Kanhere
INTRODUCTION: Extrauterine Endometrial Stromal Sarcoma (EESS) is an extremely rare mesenchymal tumour that simulates other pathologies, and therefore poses a diagnostic challenge. This report outlines a case of EESS arising from the greater omentum mimicking a colonic tumour, with review of literature. PRESENTATION OF CASE: A 47-year-old woman, with history of hysterectomy for menorrhagia and hormone replacement therapy (HRT), presented with right sided abdominal pain and localized peritonism...
April 19, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28464838/primary-extragenital-endometrial-stromal-sarcoma-of-the-lung-first-reported-case-and-review-of-literature
#4
Lara Alessandrini, Francesco Sopracordevole, Giulio Bertola, Simona Scalone, Martina Urbani, Gianmaria Miolo, Tiziana Perin, Fabrizio Italia, Vincenzo Canzonieri
BACKGROUND: Endometrial stromal sarcomas arising in extrauterine and extraovarian sites, in the absence of a primary uterine lesion are quite rare, especially in the absence of endometriosis. They usually present as an abdominal or pelvic mass lesion. CASE PRESENTATION: In 2007, a 45-year-old woman underwent total hysterectomy for in situ squamous cell carcinoma of the cervix. In 2014, an upper left pulmonary lobectomy was performed for a mass, which was provisionally diagnosed as primary carcinosarcoma of the lung...
May 2, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28403089/clinicopathological-characteristics-and-treatment-strategies-for-patients-with-low-grade-endometrial-stromal-sarcoma
#5
REVIEW
Ran Cui, Fang Yuan, Yue Wang, Xia Li, Zhenyu Zhang, Huimin Bai
To investigate and evaluate the clinicopathological characteristics and treatment strategies for patients with low-grade endometrial stromal sarcoma (LG-ESS).The medical records of LG-ESS patients who were treated at 2 cancer referral centers from January 2005 to December 2015 were retrospectively reviewed.Twenty patients with LG-ESS met the inclusion criteria and were included in this analysis. Hysterectomy with bilateral salpingo-oophorectomy was the mainstay of surgery. Lymphadenectomy was performed in 12 (60%) cases, and no positive nodes were identified...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28400352/frequency-of-uterine-sarcomas-in-patients-admitted-for-uterine-fibroids-surgery
#6
Liselotte Mettler, Nicolai Maass, Khulkar Abdusattarova, Astrid Dempfle, Ibrakhim Alkatout
OBJECTIVE: To estimate the frequency of unsuspected uterine sarcoma identified postoperatively in women undergoing surgery for presumed benign uterine fibroids at the single-center university hospital. MATERIAL AND METHODS: This was a retrospective single-center study; the records of all 2,275 patients with uterine fibroids and uterine sarcomas from 2003 to 2015 were reviewed. Descriptive statistics were used to analyze demographic and clinical characteristics. To calculate confidence intervals (CIs), the exact Clopper-Pearson method was applied...
February 7, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28390819/ywhae-rearranged-high-grade-endometrial-stromal-sarcoma-two-center-case-series-and-response-to-chemotherapy
#7
Matthew L Hemming, Andrew J Wagner, Marisa R Nucci, Sarah Chiang, Lu Wang, Martee L Hensley, Suzanne George
OBJECTIVES: YWHAE-rearranged high-grade endometrial stromal sarcoma (HG-ESS) is a rare, recently defined uterine sarcoma harboring t(10;17)(q22;p13) resulting in YWHAE-NUTM2A/B fusion. Chemotherapy sensitivity of metastatic YWHAE-rearranged HG-ESS is unknown. We reviewed the response to chemotherapy in women with YWHAE-rearranged HG-ESS to provide guidance for clinical management. METHODS: We retrospectively identified patients diagnosed with YWHAE-rearranged HG-ESS who received treatment for metastatic disease at our institutions...
April 5, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28384878/a-rare-collision-tumour-of-uterus-squamous-cell-carcinoma-and-endometrial-stromal-sarcoma
#8
Nadeem Tanveer, Bindiya Gupta, Abhishek Pathre, Shalini Rajaram, Neerja Goyal
Collision tumours are defined by co-existence of two tumours in the same or adjacent organs which are topographically and histologically distinct with minimal or no histological admixture. Collision tumours have been described in many organs notably thyroid, brain, adrenal gland, stomach and rarely uterus. Most of the collision tumours reported in uterus have two components; an adenocarcinoma and a sarcoma. We report a case of a 60-year-old lady who presented with complaints of post-menopausal bleeding. A cervical biopsy was performed which showed a non-keratinizing squamous cell carcinoma of cervix...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28353387/recent-developments-in-surgical-pathology-of-the-uterine-corpus
#9
REVIEW
Krisztina Z Hanley, George G Birdsong, Marina B Mosunjac
There have been several updates recently on the classification of uterine tumors. Endometrial carcinomas have traditionally been divided into 2 types, but some are difficult to classify and do not fit readily into either of the currently recognized categories. The Cancer Genome Atlas Research Network has recently defined 4 new categories of endometrial cancer on the basis of mutational spectra, copy number alteration, and microsatellite instability, which might provide independent prognostic information beyond established risk factors...
April 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28335657/molecular-characteristics-of-uterine-sarcomas
#10
Ben Davidson, Francesca Micci
Uterine sarcomas are rare cancers, of which the most common entities are leiomyosarcoma and endometrial stromal sarcoma. These two tumors may have overlapping clinical presentation, morphology and immunohistochemical profile, but are increasingly recognized to be two molecularly distinct entities. Endometrial stromal sarcomas are further currently divided into a low-grade and high-grade group based on molecular characteristics. Area covered: This review discusses recent data which shed light on the molecular profile of these two cancers and may aid in understanding their evolution and progression, in the aim of improving their diagnosis and management...
May 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28331900/a-recurrent-endometrial-stromal-sarcoma-harbors-the-novel-fusion-jazf1-bcorl1
#11
Allison J Allen, Siraj M Ali, Kyle Gowen, Julia A Elvin, Tanja Pejovic
•Genomic alterations may improve diagnostic certainty and subsequent treatment of endometrial stromal sarcoma.•Novel JAZF1-BCORL1 mutation was identified.•Targeted therapeutics to down-stream targets may improve survival benefit in these patients.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28299760/uterine-sarcomas-the-latest-approaches-for-these-rare-but-potentially-deadly-tumors
#12
REVIEW
Jing-Yi Chern, Leslie R Boyd, Stephanie V Blank
Uterine sarcomas are rare malignant uterine neoplasms that are responsible for a large majority of uterine cancer-associated deaths. The subtypes include leiomyosarcomas, endometrial stromal tumors, and adenosarcomas. Standard treatment includes complete surgical resection. Adjuvant treatment with chemotherapy, hormonal therapy, or radiation may be considered in patients with high-risk disease. However, because the ability of adjuvant treatment to improve overall survival in patients with uterine sarcomas is unclear, there is no standard recommendation regarding adjuvant therapy...
March 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28288693/uterine-epithelioid-leiomyosarcoma-with-c-kit-expression-and-ywhae-gene-rearrangement-a-case-report-of-a-diagnostic-pitfall-of-uterine-sarcoma
#13
Terufumi Kubo, Shintaro Sugita, Ryuichi Wada, Noriaki Kikuchi, Masahiro Iwasaki, Yumika Ito, Taro Sugawara, Hiromi Fujita, Makoto Emori, Ryoichi Tanaka, Hiroshi Hirano, Tsuyoshi Saito, Tadashi Hasegawa
BACKGROUND: Uterine sarcoma is a rare tumor that is often difficult to classify based on morphological and immunohistochemical analysis alone. Limited access to molecular biological analysis in routine practice would hinder making a definitive diagnosis. CASE PRESENTATION: In this report, we describe a case of a mesenchymal tumor arising from the uterine cervix in a 52-year-old woman. From microscopic morphology of the resected specimen, epithelioid leiomyosarcoma, high-grade endometrial stromal sarcoma, or uterine gastrointestinal stromal tumor (GIST) were considered as differential diagnoses...
March 14, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28275572/magnetic-resonance-imaging-features-of-endometrial-stromal-sarcoma-a-case-description
#14
Chen Chen, You-Qiang Hu, Xiao-Ming Zhang
No abstract text is available yet for this article.
February 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28271093/uterine-sarcoma-with-ambiguous-histomorphology-a-case-report
#15
Eirwen M Miller, Yumei Fu, Ruben Barrera Vera, Gary L Goldberg, Rouzan G Karabakhtsian
BACKGROUND: Leiomyosarcomas (LMS) and endometrial stromal sarcomas (ESS) may display overlapping histomorphology, which may challenge diagnostic accuracy. Since LMS and ESS have vastly different clinical behavior and adjuvant therapy recommendations, accurate diagnosis is critical. CASE: We present the case of an 83-year-old female with postmenopausal bleeding who underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy for clinically atypical appearing leiomyomata...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28254678/incidence-of-occult-uterine-malignancy-following-vaginal-hysterectomy-with-morcellation
#16
Megan Wasson, Paul Magtibay, Paul Magtibay, Javier Magrina
STUDY OBJECTIVE: To determine the incidence and impact of occult uterine malignancy following vaginal hysterectomy and uncontained morcellation. DESIGN: An Institutional Review Board-approved retrospective cohort study (Canadian Task Force classification II-2). SETTING: Three academic medical centers. PATIENTS: All women who underwent vaginal hysterectomy between January 1, 2008, and August 31, 2015, at 3 institutions were considered for inclusion in the study...
May 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28246921/magnetic-resonance-imaging-features-of-uterine-sarcoma-and-mimickers
#17
REVIEW
Matthias Barral, Vinciane Placé, Raphaël Dautry, Sandra Bendavid, Françoise Cornelis, Romain Foucher, Youcef Guerrache, Philippe Soyer
Uterine myometrial tumors are predominantly benign conditions that affect one-third of women and represent the main indication for hysterectomy. Preoperative imaging is of utmost importance for characterization and for precise mapping of myometrial tumors to best guide therapeutic strategy. New minimally invasive therapeutic strategies including morcellation, myolysis, uterine artery embolization and image-guided radiofrequency or focused ultrasound ablation have been developed for the treatment of uterine leiomyoma...
February 28, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28170091/prevalence-of-occult-pre-malignant-or-malignant-pathology-at-the-time-of-uterine-morcellation-for-benign-disease
#18
Emily C Von Bargen, Cara L Grimes, Kavita Mishra, Rui Wang, Miriam J Haviland, Michele R Hacker, Joseph A Carnevale, Alyssa J Estes, Eman A Elkadry
OBJECTIVE: To determine the prevalence of occult pre-malignant or malignant uterine pathology at the time of laparoscopic surgery with open power morcellation for benign gynecologic disease. METHOD: The present multicenter, retrospective cohort study included women who underwent open power morcellation for benign indications between January 1, 2007, and February 28, 2014, at three academic medical centers in the USA. The primary outcome was pre-malignant or malignant pathology at the time of open power morcellation, and was determined from the patients' pathology reports...
February 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28120430/morcellating-uterine-mesenchymal-tumors-the-pathologist-s-view
#19
Kitty Pavlakis, Irini Messini, Petros Yiannou, Theofani Gavresea, Dimitris Chrysanthakis, Georgios Hilaris, Theodoros Panoskaltsis
AIM: The study was conducted to delineate the histological problems in diagnosing uterine mesenchymal tumors in morcellated material. METHODS: All cases of morcellated uteri performed between 2008 and 2014 were reviewed. The incidence of unexpected malignancy, defined as any neoplasm with a clear-cut diagnosis of leiomyosarcoma (LMS) or endometrial stromal sarcoma (ESS), was noted. Cases with absolute discrepancy between the diagnosis of the morcellated tumor and the subsequent diagnosis were also included in the study...
January 25, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28114189/androgen-receptor-expression-in-endometrial-stromal-sarcoma-correlation-with-clinicopathologic-features
#20
Maitrayee Roy, Sunesh Kumar, Neerja Bhatla, Mukurdipi D Ray, Lalit Kumar, Deepali Jain, Ravi Phulware, Sandeep R Mathur
Endometrial stromal sarcoma (ESS) is a rare neoplasm comprising only 0.2% to 1% of all uterine malignancies and afflicts women between 42 and 59 yr of age. ESSs frequently express estrogen receptor (ER) and progesterone receptor (PR). However, the published literature contains scant data on the expression and therapeutic/prognostic role of androgen receptor (AR) in ESSs. We undertook this study to characterize the expression of AR along with ER and PR in ESSs and correlate it with clinicopathologic features...
January 20, 2017: International Journal of Gynecological Pathology
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