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https://www.readbyqxmd.com/read/29471549/glutamate-dehydrogenase-deficient-mice-display-schizophrenia-like-behavioral-abnormalities-and-ca1-specific-hippocampal-dysfunction
#1
Sharon S Lander, Usman Khan, Nicole Lewandowski, Darpan Chakraborty, Frank A Provenzano, Susana Mingote, Sergiy Chornyy, Francesca Frigerio, Pierre Maechler, Hanoch Kaphzan, Scott A Small, Stephen Rayport, Inna Gaisler-Salomon
Brain imaging has revealed that the CA1 subregion of the hippocampus is hyperactive in prodromal and diagnosed patients with schizophrenia (SCZ), and that glutamate is a driver of this hyperactivity. Strikingly, mice deficient in the glutamate synthetic enzyme glutaminase have CA1 hypoactivity and a SCZ-resilience profile, implicating glutamate-metabolizing enzymes. To address this further, we examined mice with a brain-wide deficit in the glutamate-metabolizing enzyme glutamate dehydrogenase (GDH), encoded by Glud1, which should lead to glutamate excess due to reduced glutamate metabolism in astrocytes...
February 20, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29471216/toward-true-closed-loop-neuromodulation-artifact-free-recording-during-stimulation
#2
REVIEW
Andy Zhou, Benjamin C Johnson, Rikky Muller
Closed-loop and responsive neuromodulation systems improve open-loop neurostimulation by responding directly to measured neural activity and providing adaptive, on-demand therapy. To be effective, these systems must be able to simultaneously record and stimulate neural activity, a task made difficult by persistent stimulation artifacts that distort and obscure underlying biomarkers. To enable simultaneous stimulation and recording, several techniques have been proposed. These techniques involve artifact-preventing system configurations, resilient recording front-ends, and back-end signal processing for removing recorded artifacts...
February 19, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29471203/significance-of-an-in-situ-generated-boundary-film-on-tribocorrosion-behavior-of-polymer-metal-sliding-pair
#3
Yongkun Xu, Huimin Qi, Guitao Li, Xueping Guo, Yong Wan, Ga Zhang
Polymer composites have a high potential for applications as tribo-materials exposed to sea water owing to their self-lubrication characteristic and high chemical stability. In the present work, tribological behaviors of polyetheretherketone (PEEK) composites rubbing with stainless steel in sea water were explored using a pin-on-disc tribometer integrated with a potentiostat for electrochemical control. It was demonstrated that further adding 5 vol% hexagonal boron nitride (h-BN) nanoparticles into PEEK reinforced with short carbon fibers (SCF) significantly enhanced the wear resistance...
February 13, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29471082/anhedonic-behavior-and-%C3%AE-amino-butyric-acid-during-a-sensitive-period-in-female-rats-exposed-to-early-adversity
#4
Jodi L Lukkes, Shirisha Meda, Kevin J Norman, Susan L Andersen
Early life adversity increases depressive behavior that emerges during adolescence. Sensitive periods have been associated with fewer GABAergic interneurons, especially parvalbumin (PV), brain derived growth factor, and its receptor, TrkB. Here, maternal separation (MS) and social isolation (ISO) were used to establish a sensitive period for anhedonic depression using the learned helplessness (LH) paradigm. Female Sprague-Dawley rat pups underwent MS for 4-h/day or received typical care (CON) between postnatal days 2-20; for the ISO condition, separate cohorts were individually housed between days 20-40 or served as controls (CON2)...
February 13, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29471015/biological-profiling-of-plasma-neuropeptide-y-in-relation-to-posttraumatic-stress-symptoms-in-two-combat-cohorts
#5
Alieke Reijnen, Elbert Geuze, Iris Eekhout, Adam X Maihofer, Caroline M Nievergelt, Dewleen G Baker, Eric Vermetten
In order to decrease the risk of developing stress-related disorders after military deployment, biological vulnerability factors should be identified. Neuropeptide Y (NPY) is a peptide neurotransmitter that is associated with modulation of the stress response. Using the data of two longitudinal prospective cohort studies (N = 892 and N = 2427), plasma NPY (pNPY) was assessed as a possible susceptibility biomarker for the development of PTSD symptoms over time. Data collection started prior to deployment and follow-up assessments were completed up to two years after deployment...
February 19, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29470746/nitinol-stents-in-the-femoropopliteal-artery-a-mechanical-perspective-on-material-design-and-performance
#6
REVIEW
Kaspars Maleckis, Eric Anttila, Paul Aylward, William Poulson, Anastasia Desyatova, Jason MacTaggart, Alexey Kamenskiy
Endovascular stenting has matured into a commonly used treatment for peripheral arterial disease (PAD) due to its minimally invasive nature and associated reductions in short-term morbidity and mortality. The mechanical properties of the superelastic Nitinol alloy have played a major role in the explosion of peripheral artery stenting, with modern stents demonstrating reasonable resilience and durability. Yet in the superficial femoral and popliteal arteries, even the newest generation Nitinol stents continue to demonstrate clinical outcomes that leave significant room for improvement...
February 22, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29470601/expansionary-adaptive-transformations-of-socio-hydrological-systems-shss-the-case-of-drought-in-messara-plain-crete-greece
#7
Kalliopi Sapountzaki, Ioannis Daskalakis
The paper attempts to document the ontology of socio-hydrological systems (SHSs), propose approaches of delimitation of SHSs' (territorial) boundaries, and investigate operational aspects of their adaptation to drought including repercussions on sustainability. To this end, a series of hypotheses are tested: (a) SHSs contain social subsystems with different expectations regarding water resources, different adaptive capacities, adaptation limits and prospects of sustainability, (b) SHSs do not adapt homogenously; some of their subsystems manage optimum adaptation, others fail to adapt and (c) territorial transformation of SHSs (e...
February 22, 2018: Environmental Management
https://www.readbyqxmd.com/read/29470532/psychosocial-health-and-suicidal-ideation-among-people-living-with-hiv-aids-a-cross-sectional-study-in-nanjing-china
#8
Wei Wang, Chenchang Xiao, Xing Yao, Yinmei Yang, Hong Yan, Shiyue Li
BACKGROUND: Suicide is a serious cause of mortality worldwide and is considered as a psychiatric emergency. People living with HIV/AIDS (PLWHA) have higher rates of suicidal behavior than the general population. This study assessed the prevalence and verified the syndemic effect of psychosocial health conditions on suicidal ideation among PLWHA in China. METHODS: An institutional-based cross-sectional study was conducted from July to August 2016 in Nanjing, China, using a self-report questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29469926/folic-acid-supplementation-throughout-pregnancy-psychological-developmental-benefits-for-children
#9
Lesley-Anne Henry, Tony Cassidy, Marian McLaughlin, Kristina Pentieva, Helene McNulty, Colum P Walsh, Diane Lees-Murdock
AIM: To test the effect of folic acid supplements taken throughout pregnancy on children's psychosocial development. METHOD: A randomised controlled trial of folic acid supplementation in pregnancy, with parental rating using the Resiliency Attitudes and Skills Profile (RASP), the Strengths and Difficulties Questionnaire (SDQ), and the Trait Emotional Intelligence Questionnaire Child Short Form (TEIQue-CSF). Children aged 6-7 whose mothers received folic acid throughout pregnancy (n= 22) were compared to those whose mothers only received it during the first trimester (n=17)...
February 22, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29469238/fire-retardant-and-thermally-insulating-phenolic-silica-aerogels
#10
Zhi-Long Yu, Ning Yang, Varvara Apostolopoulou-Kalkavoura, Bing Qin, Zhi-Yuan Ma, Wei-Yi Xing, Chan Qiao, Lennart Bergström, Markus Antonietta, Shu-Hong Yu
Energy efficient buildings require materials with a low thermal conductivity and a high fire resistance. Traditional organic insulation materials are limited by a poor fire resistance and inorganic insulation materials display a high thermal conductivity. Here we report a mechanically resilient organic/inorganic composite aerogel with a thermal conductivity significantly lower than expanded polystyrene and excellent fire resistance. Co-polymerization and nanoscale phase separation of the phenol-formaldehyde-resin (PFR) and silica generate a binary network with domain sizes below 20 nm...
February 22, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29468687/genome-wide-association-mapping-of-the-architecture-of-susceptibility-to-the-root-knot-nematode-meloidogyne-incognita-in-arabidopsis-thaliana
#11
Sonja Warmerdam, Mark G Sterken, Casper van Schaik, Marian E P Oortwijn, Octavina C A Sukarta, Jose L Lozano-Torres, Marcel Dicke, Johannes Helder, Jan E Kammenga, Aska Goverse, Jaap Bakker, Geert Smant
Susceptibility to the root-knot nematode Meloidogyne incognita in plants is thought to be a complex trait based on multiple genes involved in cell differentiation, growth and defence. Previous genetic analyses of susceptibility to M. incognita have mainly focused on segregating dominant resistance genes in crops. It is not known if plants harbour significant genetic variation in susceptibility to M. incognita independent of dominant resistance. To study the genetic architecture of susceptibility to M. incognita, we analysed nematode reproduction on a highly diverse set of 340 natural inbred lines of Arabidopsis thaliana with genome-wide association mapping...
February 22, 2018: New Phytologist
https://www.readbyqxmd.com/read/29468533/recalled-early-life-adversity-and-pain-the-role-of-mood-sleep-optimism-and-control
#12
Ambika Mathur, Jennifer E Graham-Engeland, Danica C Slavish, Joshua M Smyth, Richard B Lipton, Mindy J Katz, Martin J Sliwinski
Early life adversity (ELA) has been associated with pain symptomatology in adulthood, but mechanisms and moderators of these associations are unclear. Using recall based and concurrently assessed self-report data, we examined associations between ELA, mood, sleep, and recent pain intensity and interference, and whether optimism and perceived control weakened these associations in a midlife community sample of diverse adults reporting some ELA. Controlling for demographic variables and BMI, higher levels of ELA were associated with more pain intensity and interference; greater sleep disturbance and negative mood accounted for these associations...
February 21, 2018: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29468357/sensitive-fathering-buffers-the-effects-of-chronic-maternal-depression-on-child-psychopathology
#13
Adam Vakrat, Yael Apter-Levy, Ruth Feldman
Maternal depression across the first years of life carries long-term negative consequences for children's well-being; yet, few studies focused on fathers as potential source of resilience in the context of chronic maternal depression. Utilizing an extreme-case design, a community birth cohort of married/cohabitating mothers (N = 1983) with no comorbid risk was repeatedly tested for maternal depression across the first year and again at 6 years, leading to two matched cohorts; 46 mothers with chronic depression and 103 non-depressed controls...
February 21, 2018: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/29467723/impact-of-chemical-and-biological-fungicides-applied-to-grapevine-on-grape-biofilm-must-and-wine-microbial-diversity
#14
Rocío Escribano-Viana, Isabel López-Alfaro, Rosa López, Pilar Santamaría, Ana R Gutiérrez, Lucía González-Arenzana
This study was aimed to measure the impact of the application of a bio-fungicide against Botrytis cinerea on the microbiota involved in the alcoholic fermentation (AF) of Tempranillo Rioja wines. For this purpose, a bio-fungicide composed of the biological control bacterium Bacillus subtilis QST713 was applied to the vineyard. The microbial diversity was analyzed from grape biofilm to wine. Impact on microbial diversity was measured employing indexes assessed with the software PAST 3.10 P.D. Results were compared to non-treated samples and to samples treated with a chemical fungicide mainly composed by fenhexamid...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29467369/transcriptomic-signature-of-drought-response-in-pearl-millet-pennisetum-glaucum-l-and-development-of-web-genomic-resources
#15
Sarika Jaiswal, Tushar J Antala, M K Mandavia, Meenu Chopra, Rahul Singh Jasrotia, Rukam S Tomar, Jashminkumar Kheni, U B Angadi, M A Iquebal, B A Golakia, Anil Rai, Dinesh Kumar
Pearl millet, (Pennisetum glaucum L.), an efficient (C4) crop of arid/semi-arid regions is known for hardiness. Crop is valuable for bio-fortification combating malnutrition and diabetes, higher caloric value and wider climatic resilience. Limited studies are done in pot-based experiments for drought response at gene-expression level, but field-based experiment mimicking drought by withdrawal of irrigation is still warranted. We report de novo assembly-based transcriptomic signature of drought response induced by irrigation withdrawal in pearl millet...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29467051/primary-care-medical-practices-are-community-health-care-providers-ready-for-disasters
#16
Rachel M Peters, Thomas J Hipper, Esther D Chernak
OBJECTIVE: This study seeks to determine the capacity of community primary care practices to meet the needs of patients during public health emergencies and to identify the barriers and resources necessary to participate in a coordinated response with public safety agencies. METHODS: The self-administered web-based survey was distributed in January 2014 via e-mail to primary care providers in Pennsylvania using the listservs of several professional societies. RESULTS: A total of 179 primary care providers participated in the survey...
February 22, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29466995/nothing-in-cancer-makes-sense-except%C3%A2
#17
REVIEW
Mel Greaves
Paraphrasing Dobzhansky's famous dictum, I discuss how interrogating cancer through the lens of evolution has transformed our understanding of its development, causality and treatment resistance. The emerging picture of cancer captures its extensive diversity and therapeutic resilience, highlighting the need for more innovative approaches to control.
February 21, 2018: BMC Biology
https://www.readbyqxmd.com/read/29466321/in-a-quest-for-engineering-acidophiles-for-biomining-applications-challenges-and-opportunities
#18
REVIEW
Yosephine Gumulya, Naomi J Boxall, Himel N Khaleque, Ville Santala, Ross P Carlson, Anna H Kaksonen
Biomining with acidophilic microorganisms has been used at commercial scale for the extraction of metals from various sulfide ores. With metal demand and energy prices on the rise and the concurrent decline in quality and availability of mineral resources, there is an increasing interest in applying biomining technology, in particular for leaching metals from low grade minerals and wastes. However, bioprocessing is often hampered by the presence of inhibitory compounds that originate from complex ores. Synthetic biology could provide tools to improve the tolerance of biomining microbes to various stress factors that are present in biomining environments, which would ultimately increase bioleaching efficiency...
February 21, 2018: Genes
https://www.readbyqxmd.com/read/29465796/conserved-residues-are-critical-for-haloferax-volcanii-archaeosortase-catalytic-activity-implications-for-convergent-evolution-of-the-catalytic-mechanisms-of-non-homologous-sortases-from-archaea-and-bacteria
#19
Mohd Farid Abdul Halim, Ronald Rodriguez, Jonathan D Stoltzfus, Iain G Duggin, Mechthild Pohlschroder
Proper protein anchoring is key to the biogenesis of prokaryotic cell surfaces, dynamic, resilient structures that play crucial roles in various cell processes. A novel surface protein anchoring mechanism in Haloferax volcanii depends upon the peptidase archaeosortaseA (ArtA) processing C-termini of substrates containing C-terminal tripartite structures and anchoring mature substrates to the cell membrane via intercalation of lipid-modified C-terminal amino acid residues. While this membrane protein lacks clear homology to soluble sortase transpeptidases of Gram-positive bacteria, which also process C-termini of substrates whose C-terminal tripartite structures resemble those of ArtA substrates, archaeosortases do contain conserved cysteine, arginine, and arginine/histidine/asparagine residues, reminiscent of His-Cys-Arg residues of sortase catalytic sites...
February 21, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29465774/measuring-resilience-to-operational-stress-in-canadian-armed-forces-personnel
#20
Sarah C Hellewell, Ibolja Cernak
Adaptability to stress is governed by innate resilience, comprised of complex neuroendocrine and immune mechanisms alongside inherited or learned behavioral traits. Based on their capacity to adapt, some people thrive in stressful situations, whereas others experience maladaptation. In our study, we used state-of-the-art tools to assess the resilience level in individuals, as well as their susceptibility to developing military stress-induced behavioral and cognitive deficits. To address this complex question, we tested Canadian Armed Forces (CAF) personnel in three distinct stress environments (baselines): during predeployment training, deployment in Afghanistan, and readjustment upon return to Canada...
February 21, 2018: Journal of Traumatic Stress
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