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https://www.readbyqxmd.com/read/29684286/prevention-of-transfusion-associated-graft-versus-host-disease-with-blood-product-irradiation-the-past-present-and-future
#1
Burak Bahar, Christopher A Tormey
Transfusion-associated graft-versus-host disease (TA-GVHD) is a disease with a very high mortality rate. In this report, we discuss TA-GVHD from a historical perspective, highlight the pathogenesis of TA-GVHD, and emphasize the importance of blood product irradiation, which is a very effective means to prevent this disease. We summarize the current recommendations in different patient populations from different countries and review recent developments, such as alternatives for the use of radioactive materials...
May 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29680907/nlrp3-inflammasome-activation-regulates-aged-rbc-clearance
#2
Li Qin, Zhao Fengyong, Zhang Jiamin, Yang Qixiu, Lu Geming, Xia Rongwei, Zhu Ziyan
The NLR family pyrin domain-containing protein 3 (NLRP3) inflammasome is triggered by various stimuli. Whether the NLRP3 inflammasome is activated during the monocyte clearing of aged or damaged erythrocytes is unknown. This work aimed to determine whether the NLRP3 inflammasome is activated during the THP-1 cell engulfing of aged erythrocytes. In the study, THP-1 cells were treated with PMA and then coincubated with untreated red blood cells (RBCs), 42 °C-treated RBCs, immunoglobulin G (IgG) anti-D-sensitized RBCs, Rhnull/Rhmod RBC sample, hemoglobin, and RBC ghost...
April 21, 2018: Inflammation
https://www.readbyqxmd.com/read/29669792/transfusion-transmitted-infections-an-update-on-product-screening-diagnostic-techniques-and-the-path-ahead
#3
Christina L Dean, Jenna Wade, John D Roback
The first mandated testing of blood components for infectious diseases began in the 1950s to prevent transfusion-transmitted infections (TTI). Since then, changes in pre-donation questionnaires and advances in testing techniques have afforded more sensitive and specific tests for pathogens in addition to allowing for earlier detection. Given that these approaches have very low but detectable failure rates, recent development and implementation of pro-active pathogen reduction approaches is the new forefront of TTI prevention strategies...
April 18, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29669612/prehospital-blood-product-administration-opportunities-in-ground-transport-als-ems-a-descriptive-study
#4
Felicia M Mix, Martin D Zielinski, Lucas A Myers, Kathy S Berns, Anurahda Luke, James R Stubbs, Scott P Zietlow, Donald H Jenkins, Matthew D Sztajnkrycer
IntroductionHemorrhage remains the major cause of preventable death after trauma. Recent data suggest that earlier blood product administration may improve outcomes. The purpose of this study was to determine whether opportunities exist for blood product transfusion by ground Emergency Medical Services (EMS). METHODS: This was a single EMS agency retrospective study of ground and helicopter responses from January 1, 2011 through December 31, 2015 for adult trauma patients transported from the scene of injury who met predetermined hemodynamic (HD) parameters for potential transfusion (heart rate [HR]≥120 and/or systolic blood pressure [SBP]≤90)...
April 19, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29668135/-costs-of-chagas-disease-screening-test-in-blood-donors-in-two-colombian-blood-banks-2015
#5
Nelson José Alvis, Diana Patricia Díaz, Liliana Castillo, Nelson Rafael Alvis, María Isabel Bermúdez, Olga Maritza Berrío, Mauricio Beltrán, Carlos Andrés Castañeda-Orjuela
INTRODUCTION: Transfusion is a mechanism of transmission of Chagas' disease. There are no studies on the costs of the screening test in Colombian blood banks. OBJECTIVE: To estimate the costs of the screening test for Chagas' disease among blood donors in two Colombian blood banks, 2015. MATERIALS AND METHODS: We conducted a micro-costing study from the perspective of the health care provider to estimate the cost of Chagas' disease testing in two blood banks, Banco de Sangre de la Cruz Roja, Seccional Bolívar, and Banco de Sangre del Hospital de Yopal, Casanare, taking into account four cost categories: 1) Administrative costs: public services and insurance costs were calculated based on the blood bank area in square meters; 2) capital costs: building and equipment costs that were annualized using a 3% discount rate and a lifespan of 20 years for building and five for equipment; 3) costs of Chagas' disease test materials and reagents adjusted by blood bank production level, and 4) costs of staff in charge of Chagas' disease test processing...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29668040/graft-loss-attributed-to-possible-transfusion-transmitted-ehrlichiosis-following-cord-blood-stem-cell-transplant
#6
A Mah, G M Viola, E Ariza Heredia, K Rezvani, P Kebriaei, M M Bhatti, X Han, E J Shpall, V Mulanovich
We present a case of possible transfusion-transmitted Ehrlichia chaffeensis infection in a heavily transfused cord blood transplant recipient, resulting in severe infection and graft loss. Transfusion-transmitted, vector-borne infections in immunocompromised individuals can have severe consequences, and should be considered in hospitalized patients receiving blood products with unexplained fever or sepsis. This article is protected by copyright. All rights reserved.
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29667206/surveillance-of-donated-blood-during-the-2016-arbovirus-outbreak-in-brazil
#7
Rohit Sharma, Larissa Costa Santos, Robson Amaro da Silva, Caroline Vieira Gonçalves, Stéfano de Melo Calado, Denisar P Santos, Josana Passos de Andrade de Melo, Rita de Cássia Pontello Rampazzo, Luciana Requião, Marco Aurélio Krieger, Manoel Barral-Netto, Camila I de Oliveira
Reports of arboviral transmission via blood transfusion may be a cause of concern among asymptomatic infected donors. This study evaluated the presence of arboviruses in donated blood products during the 2016 outbreak in Vitória da Conquista (Bahia-Brazil). Serum samples (n = 676) were screened for ZIKV, CHIKV and the four DENV serotypes using a one-step reverse transcriptase-based Real-Time Polymerase Chain Reaction (RT-PCR). No samples tested positive for any of the targets, whereas positive controls performed as expected...
April 17, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29664740/ce-a-review-of-current-practice-in-transfusion-therapy
#8
Margaret Carman, Jennifer Schieferle Uhlenbrock, Sara Marie McClintock
Preventing and recognizing complications, including TACO, TRALI, and TRIM. ABSTRACT: In the United States, roughly 4.5 million patients per year receive transfusions of various blood products. Despite the lifesaving benefits of transfusion therapy, it is an independent risk factor for infection, morbidity, and death in critically ill patients. It's important for nurses to understand the potential complications patients face when blood products are administered and to recognize that patients who have received blood products in the past remain at risk for delayed reactions, including immune compromise and infection...
April 16, 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29664514/-damage-control-resuscitation-in-pediatric-severe-trauma
#9
Adriana Wegner Araya
INTRODUCTION: Trauma is an important cause of morbidity and mortality in the pediatric population. It has the first place in mortality in our country without considering perinatal pathologies and congenital malformations. An important percentage of early and late deaths secondary to this cau se, as well as its sequelae, could be prevented with optimal and timely resuscitation. OBJECTIVE: To review the applicability of damage control resuscitation (DCR) in severe pediatric trauma, with emphasis on medical management...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29664127/cell-free-nucleic-acids-are-present-in-blood-products-and-regulate-genes-of-innate-immune-response
#10
Sophie Waldvogel Abramowski, Diderik Tirefort, Pierre Lau, Arthur Guichebaron, Sofiane Taleb, Christine Modoux, Coralie Lemoine Chaduc, Pascale Bruyere Cerdan, Pascale Roux Lombard, Thomas Lecompte, Olivier Preynat-Seauve
BACKGROUND: Extracellular nucleic acids circulate in plasma. They are expected to be present in manufactured blood products eligible for transfusion, but little is known about their biological activity on human cells. The aim of this study is to investigate whether cell-free nucleic acids (CFNAs) are present and biologically active in red blood cell units (RBCUs), fresh frozen plasmas, and platelet concentrates. STUDY DESIGN AND METHODS: CFNAs were extracted from RBCUs, fresh frozen plasma, and platelet concentrates...
April 17, 2018: Transfusion
https://www.readbyqxmd.com/read/29664114/superior-real-time-polymerase-chain-reaction-detection-of-babesia-microti-parasites-in-whole-blood-utilizing-high-copy-bmn-antigens-as-amplification-targets
#11
Bryan Grabias, Jean Clement, Peter Krause, Timothy Lepore, Sanjai Kumar
BACKGROUND: Babesiosis is a zoonotic disease transmitted to humans by the bite of infected ticks and caused by apicomplexan parasites, most commonly Babesia microti. Additionally, blood and blood products collected from asymptomatically infected blood donors may cause transfusion-transmitted infections in recipients. Highly sensitive molecular assays that detect parasite nucleic acid are needed for laboratory diagnosis and to identify and defer clinically silent but parasitemic blood donors...
April 17, 2018: Transfusion
https://www.readbyqxmd.com/read/29663565/risk-factors-for-early-invasive-fungal-infections-in-pediatric-liver-transplant-recipients
#12
Yehonatan Pasternak, Shiri Rubin, Efraim Bilavsky, Yael Mozer-Glassberg, Itzhak Levy, Elhanan Nahum, Eran Rom, Michael Gurevich, Haim Ben-Zvi, Liat Ashkenazi-Hoffnung
BACKGROUND: Invasive fungal infections (IFIs) post-liver transplantation are a frequent cause of morbidity and mortality;however, studies reporting on these infections in the pediatric population are scarce. OBJECTIVE: To investigate the incidence and risk factors of IFIs in pediatric liver transplant recipients during the early post-transplantation period (≤3 months). MATERIALS AND METHODS: Data were collected for all pediatric liver transplant recipients registered in a national transplantation center from 2004-2014...
April 17, 2018: Mycoses
https://www.readbyqxmd.com/read/29663448/seroprevalence-molecular-epidemiology-and-quantitation-of-parvovirus-b19-dna-levels-in-iranian-blood-donors
#13
Maryam Zadsar, Arezoo Aghakhani, Mohammad Banifazl, Monireh Kazemimanesh, Seyed Morteza Tabatabaei Yazdi, Setareh Mamishi, Anahita Bavand, Mona Sadat Larijani, Amitis Ramezani
Human parvovirus B19 (B19) infection is common among blood donors, and healthy blood donors can transmit virus via transfusion. Due to resistance of B19 to viral inactivation methods, there is a potential concern regarding transfusion safety in blood products. We aimed to determine the seroprevalence, molecular epidemiology and quantitation of B19 DNA levels in blood donors in Tehran, Iran. 500 blood donors from Blood Transfusion Research Center were studied. ELISA was used for detection of B19 IgG and IgM and nested PCR was carried out for detection of B19 DNA...
April 16, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29662742/total-disc-replacement-versus-anterior-posterior-interbody-fusion-in-the-lumbar-spine-and-lumbosacral-junction-a-cost-analysis
#14
Timo Stubig, Malik Ahmed, Amir Ghasemi, Luigi Aurelio Nasto, Michael Grevitt
Study Design: Prospective observational cohort study. Objectives: To analyze clinical and economic results in patients with degenerative disc disease in the lumbar area for patients who received combined anterior and posterior fusion or total disc replacement (TDR). Methods: The study included 75 patients, 38 in the fusion group and 37 in the TDR group, who received either anterior/posterior fusion or TDR for lumbar disc disease from January 2005 to December 2008 with a minimum follow-up of 24 months...
April 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29660827/patient-blood-management-and-the-importance-of-the-transfusion-practitioner-role-to-embed-this-into-practice
#15
REVIEW
L Bielby, R L Moss
Patient blood management (PBM) is a widely established international initiative, with a multidisciplinary approach to reduce transfusion. The Transfusion Practitioner (TP) role is well embedded in the United Kingdom (UK) and Australia. The value of the TP in changing both culture and practice to implement an all-inclusive PBM approach to care will be discussed. The TP role was born from both a safety and haemovigilance culture, where the greatest identified risk to the patient undergoing a transfusion was human error...
April 16, 2018: Transfusion Medicine
https://www.readbyqxmd.com/read/29659551/time-course-investigation-of-small-molecule-metabolites-in-map-stored-red-blood-cells-using-uplc-qtof-ms
#16
Yong Zhou, Zhiyun Meng, Hui Gan, Ying Zheng, Xiaoxia Zhu, Zhuona Wu, Jian Li, Ruolan Gu, Guifang Dou
Red blood cells (RBCs) are routinely stored for 35 to 42 days in most countries. During storage, RBCs undergo biochemical and biophysical changes known as RBC storage lesion, which is influenced by alternative storage additive solutions (ASs). Metabolomic studies have been completed on RBCs stored in a number of ASs, including SAGM, AS-1, AS-3, AS-5, AS-7, PAGGGM, and MAP. However, the reported metabolome analysis of laboratory-made MAP-stored RBCs was mainly focused on the time-dependent alterations in glycolytic intermediates during storage...
April 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29658985/using-rotational-thromboelastometry-clot-firmness-at-5-minutes-rotem-%C3%A2-extem-a5-to-predict-massive-transfusion-and-in-hospital-mortality-in-trauma-a-retrospective-analysis-of-1146-patients
#17
J M Kelly, S Rizoli, P Veigas, S Hollands, A Min
Viscoelastic assays such as TEG® and ROTEM® are increasingly used to guide transfusion of blood products. The EXTEM assay maximum clot firmness (MCF) is a ROTEM measure available after 25-29 min used to guide early decisions. EXTEM A10, the clot firmness at 10 min, is an accepted early surrogate, but investigators differ on whether A5, the clot firmness at 5 min, is acceptable. We re-examined this in a retrospective observational analysis of 1146 trauma patients in one centre who had ROTEM data recorded. A5 and A10 both correlated well with maximum clot firmness, with Pearson coefficients of r = 0...
April 16, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29657946/too-cold-to-clot-does-intraoperative-hypothermia-contribute-to-bleeding-after-aortic-surgery
#18
Louis H Stein, Gregory Rubinfeld, Leora B Balsam, Patricia Ursomanno, Abe DeAnda
Background: We determined the impact of intraoperative hypothermia on postoperative bleeding after thoracic aortic surgery. Methods: We retrospectively analyzed 98 consecutive patients who underwent aortic surgery with deep hypothermic circulatory arrest between 2010 and 2014. We evaluated lowest temperature, absolute decrease in temperature, and rewarming rate. Univariate and multivariate regression were used to determine relationships between temperature, clinical characteristics, and measures of postoperative bleeding...
August 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/29652280/relationship-between-maximum-clot-firmness-in-rotem-%C3%A2-and-postoperative-bleeding-after-coronary-artery-bypass-graft-surgery-in-patients-using-clopidogrel
#19
Rasoul Azarfarin, Fereidoon Noohi, Majid Kiavar, Ziae Totonchi, Avaz Heidarpour, Amir Hendiani, Zahra Sadat Koleini, Saeid Rahimi
Background: The aim of the present study was to investigate the relationship between maximum clot firmness (MCF) in rotational thromboelastometry (ROTEM® ) and postoperative bleeding in patients on clopidogrel after emergency coronary artery bypass graft surgery (CABG). Methods: This observational study recruited 60 patients posted for emergency CABG following unsuccessful primary percutaneous coronary intervention (PCI) while on 600 mg of clopidogrel. The study population was divided into 2 groups on the basis of their MCF in the extrinsically activated thromboelastometric (EXTEM) component of the (preoperative) ROTEM® test: patients with MCF <50 mm (n = 16) and those with MCF ≥50 mm (n = 44)...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29645287/seroprevalence-molecular-epidemiology-and-quantitation-of-parvovirus-b19-dna-levels-in-iranian-blood-donors
#20
Maryam Zadsar, Arezoo Aghakhani, Mohammad Banifazl, Monireh Kazemimanesh, Seyed Morteza Tabatabaei Yazdi, Setareh Mamishi, Anahita Bavand, Mona Sadat Larijani, Amitis Ramezani
Human parvovirus B19 (B19) infection is common among blood donors, and healthy blood donors can transmit virus via transfusion. Due to resistance of B19 to viral inactivation methods, there is a potential concern regarding transfusion safety in blood products. We aimed to determine the seroprevalence, molecular epidemiology and quantitation of B19 DNA levels in blood donors in Tehran, Iran. 500 blood donors from Blood Transfusion Research Center were studied. ELISA was used for detection of B19 IgG and IgM and nested PCR was carried out for detection of B19 DNA...
April 12, 2018: Journal of Medical Virology
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