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https://www.readbyqxmd.com/read/29907206/rotational-thromboelastometry-thresholds-for-patients-at-risk-for-massive-transfusion
#1
Gregory R Stettler, Ernest E Moore, Geoffrey R Nunns, Jim Chandler, Erik Peltz, Christopher C Silliman, Anirban Banerjee, Angela Sauaia
BACKGROUND: Goal-directed hemostatic resuscitation based on thrombelastography has a survival benefit compared to conventional coagulation assays. While thrombelastography transfusion thresholds for patients at risk for massive transfusion (MT) have been defined, similar cutoffs do not exist for the other commonly used viscoelastic assay, rotational thromboelastometry (ROTEM). The purpose of this study was to develop ROTEM blood product thresholds in patients at risk for MT. METHODS: ROTEM was assessed in trauma activation patients admitted from 2010 to 2016 (n = 222)...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29904575/recent-advances-in-transfusions-in-neonates-infants
#2
REVIEW
Ruchika Goel, Cassandra D Josephson
Transfusions of red blood cells (RBCs), platelets, and plasma are critical therapies for infants and neonates (particularly preterm neonates) in the neonatal intensive care unit, who are the most frequently transfused subpopulation across all ages. Although traditionally a significant gap has existed between the blood utilization and the evidence base essential to adequately guide transfusion practices in infants and neonates, pediatric transfusion medicine is evolving from infancy and gradually coming of age...
2018: F1000Research
https://www.readbyqxmd.com/read/29902958/life-threatening-pancreatitis-in-jehovah-s-witness-patients-with-severe-anemia-treated-without-transfusions-and-by-interventional-radiology-techniques
#3
Patrick Kishi, Eric vanSonnenberg, Misa Stroker
Blood transfusions in anemic patients frequently are used for critically ill patients as a life-saving therapeutic maneuver. Jehovah's Witness (JW) patients typically refuse blood transfusions due to religious beliefs. Numerous clinical reports, in a wide spectrum of medical specialties, have shown no greater morbidity or mortality in JW patients or others who refused transfusions compared to those patients who accept transfusions. We report our experience with two JW patients who presented with severe anemia and life-threatening pancreatitis...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29901639/reversible-splenial-lesion-syndrome-after-blood-transfusion-presents-callosal-disconnection-syndrome-a-case-report
#4
Xinxin Ma, Wen Su, Haibo Chen
RATIONALE: Reversible splenial lesion syndrome (RESLES) is a reversible condition with an excellent prognosis in most patients. The clinical features include altered states of consciousness, delirium, headache, and seizures, but no callosal disconnection syndromes have been described in RESLES. PATIENT CONCERNS: We presented a 57-year-old patient with alien hand syndrome, autotopagnosia, gait disorders, and left ideomotor apraxia after blood transfusion. The brain magnetic resonance imaging (MRI) showed a few regions with high signal intensity in the genu, body, and splenium of the right corpus callosum on diffusion weighted images...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29899767/spontaneous-concurrent-intraspinal-and-intracranial-subdural-hematoma-management-and-review-of-literature
#5
REVIEW
Guru Dutta Satyarthee, Faiz Ahmad
Concurrent occurrence of subdural hematoma (SDH) in the cranial as well as spinal compartment of craniospinal axis is extremely uncommon. In a detailed PubMed/Medline search, we could find only four cases of spontaneous concurrent craniospinal SDH, and adding our one case to the preexisting literature and thus reviewing total five cases. Spontaneous concurrent intraspinal and intracranial subdural hematoma affected exclusively male in their fourth to fifth decades of life with a mean age of 37.4 years (range 14-59 years)...
January 2018: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29894326/stress-urinary-incontinence-surgery-in-washington-state-before-and-after-introduction-of-the-mesh-midurethral-sling
#6
Lauren E Stewart, Michelle A Eston, Rebecca G Symons, Michael F Fialkow, Anna C Kirby
OBJECTIVES: Mesh midurethral slings (MUSs) are safe, effective treatments for female stress urinary incontinence (SUI), but many companies have ceased production because of controversies surrounding transvaginal mesh. To determine if introduction of MUS has increased the complication rate associated with SUI surgery, we compared women undergoing SUI surgery in the MUS era to those who had surgery prior its introduction. METHODS: This was a retrospective cohort study of a statewide hospital discharge database...
June 12, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29893672/histidine-tryptophan-ketoglutarate-solution-versus-blood-cardioplegia-in-cardiac-surgery-a-propensity-score-matched-analysis
#7
Alejandro Pizano, Felix Ramon Montes, Marisol Carreño, Dario Echeverri, Juan Pablo Umaña
BACKGROUND: Choosing a cardioplegic solution is a significant issue in modern cardiac surgery. Although different options are available, the optimal strategy for myocardial protection has not been established. The aim of this study was to compare intraoperative and postoperative effects of histidine-tryptophan-ketoglutarate (HTK) solution with those of standard blood cardioplegia with St Thomas No 2 solution. The study was conducted using a large cohort of adult patients undergoing complex cardiac surgery...
May 11, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/29891441/adverse-events-associated-with-infusion-of-hematopoietic-stem-cell-products-a-prospective-and-multicenter-surveillance-study
#8
REVIEW
Kazuhiko Ikeda, Hitoshi Ohto, Yoshiki Okuyama, Minami Yamada-Fujiwara, Heiwa Kanamori, Shin-Ichiro Fujiwara, Kazuo Muroi, Takehiko Mori, Kinuyo Kasama, Tohru Iseki, Tokiko Nagamura-Inoue, Nobuharu Fujii, Takashi Ashida, Kazuaki Kameda, Junya Kanda, Asao Hirose, Tsutomu Takahashi, Kazuhiro Nagai, Keiji Minakawa, Ryuji Tanosaki
Adverse events (AEs) associated with blood transfusions, including component-specific red cell, platelet, and plasma products, have been extensively surveyed. In contrast, surveillance of AEs associated with hematopoietic stem cell (HSC) products in HSC transplantation (HSCT) has been less rigorous, even though HSC products include a diversity of immature and mature hematopoietic cells, substantial plasma, and dimethyl sulfoxide (DMSO) in the case of cryopreserved HSC products. HSC infusion-related AEs have been attributed to DMSO toxicity, but AEs associated with the infusion of noncryopreserved HSC products are not uncommon...
June 1, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29889757/maternal-complications-associated-with-periviable-birth
#9
Robert M Rossi, Emily A DeFranco
OBJECTIVE: To quantify the rate of maternal complications associated with a periviable birth in a contemporary population of live births in the state of Ohio. METHODS: We conducted a population-based retrospective cohort study of all live births in Ohio (2006-2015). Maternal, obstetric, and neonatal characteristics were compared between women who delivered in the periviable period (20-25 weeks of gestation) with those who delivered preterm (26-36 weeks of gestation) and at term (greater than 36 weeks of gestation)...
June 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29880248/red-cell-transfusion-in-paediatric-patients-with-thalassaemia-and-sickle-cell-disease-current-status-challenges-and-perspectives
#10
REVIEW
Vassilis L Tzounakas, Serena I Valsami, Anastasios G Kriebardis, Issidora S Papassideri, Jerard Seghatchian, Marianna H Antonelou
Notwithstanding the high safety level of the currently available blood for transfusion and the decreasing frequency of transfusion-related complications, administration of labile blood products to paediatric patients still poses unique challenges and considerations. The incidence of thalassaemia and sickle cell disease in the paediatric population may be high enough under specific racial and geographical contexts. Red cell transfusion is the cornerstone of β-thalassaemia treatment and one of the most effective ways to prevent or correct specific acute and chronic complications of sickle cell disease...
June 4, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29879861/blood-products-transfusion-and-mid-term-outcomes-of-lung-transplanted-patients-under-extracorporeal-membrane-oxygenation-support
#11
Tommaso Pettenuzzo, Giulio Faggi, Guido Di Gregorio, Marco Schiavon, Giuseppe Marulli, Dario Gregori, Federico Rea, Carlo Ori, Paolo Feltracco
INTRODUCTION: Extracorporeal membrane oxygenation (ECMO) is considered a reliable technique in lung transplantation requiring cardiorespiratory support. However, the impact of this technology on blood product transfusion rate and outcomes compared to off-pump lung transplantation has been rarely investigated. METHODS: Between January 2012 and June 2015, 52 elective adult lung transplants were performed at our institution. Of these, 15 recipients required intraoperative venoarterial extracorporeal support and 37 did not...
January 1, 2018: Progress in Transplantation
https://www.readbyqxmd.com/read/29876866/definitive-erythropoiesis-from-pluripotent-stem-cells-recent-advances-and-perspectives
#12
Selami Demirci, John F Tisdale
Derivation of functional and mature red blood cells (RBCs) with adult globin expression from renewable source such as induced pluripotent stem cells (iPSCs) is of importance from the clinical point of view. Definitive RBC generation can only be succeeded through production of true hematopoietic stem cells (HSCs). There has been a great effort to obtain definitive engraftable HSCs from iPSCs but the results were mostly unsatisfactory due to low, short-term and linage-biased engraftment in mouse models. Moreover, ex vivo differentiation approaches ended up with RBCs with mostly embryonic and fetal globin expression...
June 7, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29863608/fibrinogen-concentrate-in-cardiovascular-surgery-a-meta-analysis-of-randomized-controlled-trials
#13
Jing-Yi Li, Junsong Gong, Fang Zhu, Jessica Moodie, Amy Newitt, Lavanya Uruthiramoorthy, Davy Cheng, Janet Martin
BACKGROUND: Postoperative bleeding remains a frequent complication after cardiovascular surgery and may contribute to serious morbidity and mortality. Observational studies have suggested a relationship between low endogenous plasma fibrinogen concentration and increased risk of postoperative blood loss in cardiac surgery. Although the transfusion of fibrinogen concentrate has been increasing, potential benefits and risks associated with perioperative fibrinogen supplementation in cardiovascular surgery are not fully understood...
May 31, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29859130/thromboelastometry-guided-hemostatic-therapy-for-hemorrhagic-shock-in-the-postoperative-period-of-vascular-surgery-a-case-report
#14
Tomaz Crochemore, Felicio A Savioli
BACKGROUND: Hemorrhagic shock is a medical emergency that often complicates vascular surgery and can lead to death. Hemorrhagic shock is characterized by hypoperfusion and hemodynamic abnormalities leading to the collapse of homeostasis due to massive blood loss. Early diagnosis is critical for a favorable outcome. Thromboelastometry has been considered an effective tool for bleeding management in critically ill patients. Thromboelastometry can guide transfusion therapy quickly, reducing the need for blood products...
June 2, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29808041/topical-use-of-tranexamic-acid-in-open-heart-surgery
#15
Farid Ahmad Chaudhary, Zahid Pervaz, Sana Ilyas, Muhammad Nabeel Niaz
OBJECTIVE: To determine the efficacy of topical pouring of tranexamic acid in reducing post-operative mediastinal bleeding, requirement for blood products and the rate of re-exploration for re-securing haemostasis or relief of pericardial tamponade after open heart surgery. METHODS: The prospective, randomised, placebo-controlled, double-blind comparative study was conducted from March 2013 to September 2015 at Rehmatul-lil-Alameen Institute of Cardiology, Punjab Employees Social Security Institution, Lahore, and comprised patients scheduled for primary isolated elective or urgent open heart surgery...
April 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29806537/chikungunya-fever-a-threat-to-global-public-health
#16
Raíza Nara Cunha Moizéis, Thales Allyrio Araújo de Medeiros Fernandes, Paulo Marcos da Matta Guedes, Hannaly Wana Bezerra Pereira, Daniel Carlos Ferreira Lanza, Judson Welber Veríssimo de Azevedo, Josélio Maria de Araújo Galvão, José Veríssimo Fernandes
Chikungunya fever is an emerging arbovirus infection, representing a serious public health problem. Its etiological agent is the Chikungunya virus (CHIKV). Transmission of this virus is mainly vector by mosquitoes of the genus Aedes, although transmission by blood transfusions and vertical transmission has also been reported. The disease presents high morbidity caused mainly by the arthralgia and arthritis generated. Cardiovascular and neurological manifestations have also been reported. The severity of the infection seems to be directly associated with the action of the virus, but also with the decompensation of preexisting comorbidities...
May 28, 2018: Pathogens and Global Health
https://www.readbyqxmd.com/read/29803284/red-blood-cell-enzyme-disorders
#17
REVIEW
Rachael F Grace, Bertil Glader
Mature red blood cells are reliant on the glycolytic pathway for energy production and the hexose monophosphate shunt for cell protection from oxidative insults. The most common red blood cell enzyme disorders are characterized by hemolysis but with wide clinical variability. Glucose-6-phosphate dehydrogenase deficiency is the most common red cell enzyme disorder worldwide. Frequent clinical presentations include neonatal jaundice and episodic hemolysis after exposure to oxidative stress. Symptoms of pyruvate kinase deficiency and other glycolytic enzyme disorders include neonatal jaundice, chronic hemolytic anemia, gallstones, and transfusion-related and transfusion-independent iron overload...
June 2018: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/29802644/safety-profile-of-uncrossmatched-cold-stored-low-titer-group-o-whole-blood-in-civilian-trauma-patients
#18
Jansen N Seheult, Marshall Bahr, Vincent Anto, Louis H Alarcon, Alain Corcos, Jason L Sperry, Darrell J Triulzi, Mark H Yazer
BACKGROUND: The use of cold-stored low-titer group O whole blood (LTOWB) for civilian trauma patients is gaining popularity. However, hemolysis might occur among non-group O recipients. This study evaluated the serologic safety of transfusing up to 4 units of LTOWB. STUDY DESIGN AND METHODS: Hypotensive male and at least 50-year-old female trauma patients who received leukoreduced, uncrossmatched, group O+, low-titer (<50 anti-A and anti-B), platelet-replete whole blood during initial resuscitation were included in this prospective, observational study...
May 25, 2018: Transfusion
https://www.readbyqxmd.com/read/29795417/bloodless-tandem-autologous-transplant-in-jehovah-s-witness-patients
#19
Rafiullah Khan, Sarah L Mott, Allyson Schultz, Y S Jethava, Guido Tricot
Tandem autologous transplants are generally the preferred therapy for newly diagnosed intermediate- and high-risk myeloma patients. More Jehovah's Witnesses (JW) are receiving single autologous peripheral blood stem cell transplants (PBSCTs). However, tandem autologous transplants have not been reported in JW patients. We performed a retrospective study of 54 patients, including four JW patients who received tandem autologous transplants between August 2000 and January 2017 and the last 50 consecutive tandem autologous transplants performed between August 2014 and August 2016...
May 24, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29791173/-rotational-thromboelastometry-in-therapy-of-life-threatening-bleeding
#20
Miroslav Durila
Bleeding and coagulopathy is a common problem in the fields of internal medicine. In case of life-threatening bleeding, rotational thromboelastometry (ROTEM) has critical role in diagnosis and therapy of coagulopathy. In contrast to commonly used tests such as prothrombin time and activated partial thromboplastin time, ROTEM evaluates coagulation of the whole blood as a bedside method. The use of ROTEM for rapid diagnosis and targeted therapy of coagulopathy leads to reduction in bleeding and thus to reduction in administration of blood transfusion products...
2018: Vnitr̆ní Lékar̆ství
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