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https://www.readbyqxmd.com/read/27679533/characteristics-and-outcomes-of-very-elderly-enrolled-in-a-prehospital-stroke-research-study
#1
Nerses Sanossian, Kathleen C Apibunyopas, David S Liebeskind, Sidney Starkman, Adrian M Burgos, Robin Conwit, Marc Eckstein, Frank Pratt, Sam Stratton, Scott Hamilton, Jeffrey L Saver
BACKGROUND AND PURPOSE: Greater numbers of individuals aged ≥80 years enjoy a high quality of life, yet historically stroke trials have excluded this population. We aimed to describe a population of very elderly successfully enrolled into an acute stroke trial and compare their characteristics and outcomes with the younger cohort. METHODS: We analyzed consecutive patients enrolled <2 hours of symptom onset in a prehospital stroke treatment trial, the FAST-MAG clinical trial (Field Administration of Stroke Therapy-Magnesium)...
November 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27679532/inclusion-of-older-people-in-trials-lessons-from-fast-mag-field-administration-of-stroke-therapy-magnesium
#2
Richard I Lindley
No abstract text is available yet for this article.
November 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27521199/subarachnoid-hemorrhage-an-update
#3
REVIEW
Jeremy S Dority, Jeffrey S Oldham
Subarachnoid hemorrhage (SAH) is a debilitating, although uncommon, type of stroke with high morbidity, mortality, and economic impact. Modern 30-day mortality is as high as 40%, and about 50% of survivors have permanent disability. Care at high-volume centers with dedicated neurointensive care units is recommended. Euvolemia, not hypervolemia, should be targeted, and the aneurysm should be secured early. Neither statin therapy nor magnesium infusions should be initiated for delayed cerebral ischemia. Cerebral vasospasm is just one component of delayed cerebral edema...
September 2016: Anesthesiology Clinics
https://www.readbyqxmd.com/read/27461851/phosphate-binding-agents-in-adults-with-ckd-a-network-meta-analysis-of-randomized-trials
#4
Suetonia C Palmer, Sharon Gardner, Marcello Tonelli, Dimitris Mavridis, David W Johnson, Jonathan C Craig, Richard French, Marinella Ruospo, Giovanni F M Strippoli
BACKGROUND: Guidelines preferentially recommend noncalcium phosphate binders in adults with chronic kidney disease (CKD). We compare and rank phosphate-binder strategies for CKD. STUDY DESIGN: Network meta-analysis. SETTING & POPULATION: Adults with CKD. SELECTION CRITERIA FOR STUDIES: Randomized trials with allocation to phosphate binders. INTERVENTIONS: Sevelamer, lanthanum, iron, calcium, colestilan, bixalomer, nicotinic acid, and magnesium...
July 22, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27439768/is-the-association-between-vitamin-d-and-metabolic-syndrome-independent-of-other-micronutrients
#5
Hossein Khosravi-Boroujeni, Faruk Ahmed, Nizal Sarrafzadegan
The incidence of metabolic syndrome (MetS) has been increasing globally and it is recognized as a major public health problem because MetS is associated with increased risk of diabetes, stroke, cancer, and other chronic diseases. Recently, MetS has been linked to vitamin D deficiency. However, the evidence on the association between vitamin D deficiency and the risk of MetS remains inconclusive. This review therefore aims to depict the existing evidence related to MetS and vitamin D deficiency, and examined some of the possible confounders which may affect the association between vitamin D status and risk of MetS...
July 20, 2016: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/27384400/association-between-anti-apolipoprotein-a-1-antibodies-and-cardiovascular-disease-in-the-general-population-results-from-the-colaus-study
#6
Panagiotis Antiochos, Pedro Marques-Vidal, Julien Virzi, Sabrina Pagano, Nathalie Satta, François Bastardot, Oliver Hartley, Fabrizio Montecucco, François Mach, Gerard Waeber, Peter Vollenweider, Nicolas Vuilleumier
We aimed to determine the association between autoantibodies against apolipoprotein A-1 (anti-apoA-1 IgG) and prevalent cardiovascular (CV) disease (CVD) as well as markers of CV risk in the general population. Cross-sectional data were obtained from 6649 subjects (age 52.6 ± 10.7 years, 47.4 % male) of the population-based CoLaus study. CVD was defined as myocardial infarction, angina pectoris, percutaneous revascularisation or bypass grafting for ischaemic heart disease stroke or transient ischaemic attack, and was assessed according to standardised medical records...
September 27, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27354832/dilemma-in-the-emergency-setting-hypomagnesemia-mimicking-acute-stroke
#7
María Rico, Laura Martinez-Rodriguez, Davinia Larrosa-Campo, Sergio Calleja
BACKGROUND: Stroke mimics may account for up to 30% of all acute stroke consultations. However, in the emergency setting, accurate diagnosis is not always possible. METHODS: Case report and review of the literature. RESULTS: A 73-year-old woman was admitted to the emergency department with acute aphasia and right hemiparesis. The National Institute of Health Stroke Score was 21, compatible with severe stroke, so she received thrombolysis. Laboratory testing demonstrated severe hypomagnesemia...
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/27325362/novel-treatments-in-neuroprotection-for-aneurysmal-subarachnoid-hemorrhage
#8
REVIEW
Robert F James, Daniel R Kramer, Zaid S Aljuboori, Gunjan Parikh, Shawn W Adams, Jessica C Eaton, Hussam Abou Al-Shaar, Neeraj Badjatia, William J Mack, J Marc Simard
New neuroprotective treatments aimed at preventing or minimizing "delayed brain injury" are attractive areas of investigation and hold the potential to have substantial beneficial effects on aneurysmal subarachnoid hemorrhage (aSAH) survivors. The underlying mechanisms for this "delayed brain injury" are multi-factorial and not fully understood. The most ideal treatment strategies would have the potential for a pleotropic effect positively modulating multiple implicated pathophysiological mechanisms at once...
August 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27300498/utilization-of-emergent-neuroimaging-for-thrombolysis-eligible-stroke-patients
#9
Nerses Sanossian, Katherine A Fu, David S Liebeskind, Sidney Starkman, Scott Hamilton, J Pablo Villablanca, Adrian M Burgos, Robin Conwit, Jeffrey L Saver
BACKGROUND: Advances in diagnostic imaging of stroke include multimodal techniques such as noninvasive angiography and perfusion imaging. We aimed to characterize trends in neuroimaging utilization among acute stroke patients. Utilization of multimodal imaging for acute stroke in the community has remained largely uncharacterized despite its increased adoption at academic medical centers. METHODS: We quantified neuroimaging utilization in the emergency department (ED) for 1,700 hyperacute stroke patients presenting <2 hours after symptom onset who participated in the National Institutes of Health Field Administration of Stroke Therapy-Magnesium (FAST-MAG) study throughout Los Angeles and Orange Counties...
June 14, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/27267762/electrolyte-disturbances-and-risk-factors-of-acute-kidney-injury-patients-receiving-dialysis-in-exertional-heat-stroke
#10
Bancha Satirapoj, Suramanat Kongthaworn, Panbubpa Choovichian, Ouppatham Supasyndh
BACKGROUND: Exertional heat stroke (EHS) is a life-threatening illness and leads to multi-organ dysfunction including acute kidney injury (AKI). The clinical significance of abnormal electrolytes and renal outcomes in ESH patients has been poorly documented. We aim to exhibit the electrolyte abnormalities, renal outcomes and risk factors of patients with AKI receiving dialysis in EHS. METHODS: A retrospective cohort study in EHS patients between 2003 and 2014 were conducted...
2016: BMC Nephrology
https://www.readbyqxmd.com/read/27117179/what-we-learned-about-the-role-of-antenatal-magnesium-sulfate-for-the-prevention-of-cerebral-palsy
#11
REVIEW
Dwight J Rouse, Deborah Hirtz
Based on the convincing case control study of Nelson and Grether which suggested that the administration of magnesium sulfate to mothers prior to early preterm birth might protect their offspring from cerebral palsy, and a pilot study by John Hauth et al. at the University of Alabama at Birmingham, the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, with co-funding from the National Institute of Neurologic Disorders and Stroke embarked on the Beneficial Effects of Antenatal Magnesium (BEAM) Trial in 1997...
August 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/26984482/urinary-potassium-excretion-and-risk-of-cardiovascular-events
#12
Lyanne M Kieneker, Ron T Gansevoort, Rudolf A de Boer, Frank P Brouwers, Edith Jm Feskens, Johanna M Geleijnse, Gerjan Navis, Stephan Jl Bakker, Michel M Joosten
BACKGROUND: Observational studies on dietary potassium and risk of cardiovascular disease (CVD) have reported weak-to-modest inverse associations. Long-term prospective studies with multiple 24-h urinary samples for accurate estimation of habitual potassium intake, however, are scarce. OBJECTIVE: We examined the association between urinary potassium excretion and risk of blood pressure-related cardiovascular outcomes. DESIGN: We studied 7795 subjects free of cardiovascular events at baseline in the Prevention of Renal and Vascular End-stage Disease study, a prospective, observational cohort with oversampling of subjects with albuminuria at baseline...
May 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/26843432/myocardial-function-after-polarizing-versus-depolarizing-cardiac-arrest-with-blood-cardioplegia-in-a-porcine-model-of-cardiopulmonary-bypass
#13
Terje Aass, Lodve Stangeland, Christian Arvei Moen, Pirjo-Riitta Salminen, Geir Olav Dahle, David J Chambers, Thomais Markou, Finn Eliassen, Malte Urban, Rune Haaverstad, Knut Matre, Ketil Grong
OBJECTIVES: Potassium-based depolarizing St Thomas' Hospital cardioplegic solution No 2 administered as intermittent, oxygenated blood is considered as a gold standard for myocardial protection during cardiac surgery. However, the alternative concept of polarizing arrest may have beneficial protective effects. We hypothesize that polarized arrest with esmolol/adenosine/magnesium (St Thomas' Hospital Polarizing cardioplegic solution) in cold, intermittent oxygenated blood offers comparable myocardial protection in a clinically relevant animal model...
July 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/26807800/reversible-cerebral-vasoconstriction-syndrome-presenting-with-visual-field-defects
#14
Meisha L Raven, Alexander L Ringeisen, Angela R McAllister, Daniel W Knoch
A 45-year-old woman with a history of depression and anxiety, treated with selective serotonin reuptake inhibitors (SSRIs), experienced acute, recurrent, and severe bifrontal headaches. Over time, she developed a left homonymous hemianopia and mental status changes. MRA revealed segmental vasoconstriction of cerebral arteries in multiple vascular distributions. She was treated with a calcium-channel blocker and magnesium, and there was resolution of her symptoms and cerebrovascular changes. Her clinical course and neuroimaging findings were consistent with reversible cerebral vasoconstriction syndrome...
June 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/26658446/enrollment-yield-and-reasons-for-screen-failure-in-a-large-prehospital-stroke-trial
#15
RANDOMIZED CONTROLLED TRIAL
Dae-Hyun Kim, Jeffrey L Saver, Sidney Starkman, David S Liebeskind, Latisha K Ali, Lucas Restrepo, May Kim-Tenser, Miguel Valdes-Sueiras, Marc Eckstein, Frank Pratt, Samuel Stratton, Scott Hamilton, Robin Conwit, Nerses Sanossian
BACKGROUND AND PURPOSE: The enrollment yield and reasons for screen failure in prehospital stroke trials have not been well delineated. METHODS: The Field Administration of Stroke Therapy-Magnesium (FAST-MAG) trial identified patients for enrollment using a 2 stage screening process-paramedics in person followed by physician-investigators by cell phone. Outcomes of consecutive screening calls from paramedics to enrolling physician-investigators were prospectively recorded...
January 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/26404370/magnesium-in-prevention-and-therapy
#16
REVIEW
Uwe Gröber, Joachim Schmidt, Klaus Kisters
Magnesium is the fourth most abundant mineral in the body. It has been recognized as a cofactor for more than 300 enzymatic reactions, where it is crucial for adenosine triphosphate (ATP) metabolism. Magnesium is required for DNA and RNA synthesis, reproduction, and protein synthesis. Moreover, magnesium is essential for the regulation of muscular contraction, blood pressure, insulin metabolism, cardiac excitability, vasomotor tone, nerve transmission and neuromuscular conduction. Imbalances in magnesium status-primarily hypomagnesemia as it is seen more common than hypermagnesemia-might result in unwanted neuromuscular, cardiac or nervous disorders...
September 2015: Nutrients
https://www.readbyqxmd.com/read/26308509/cerebral-protection-during-neurosurgery-and-stroke
#17
REVIEW
Rafael Badenes, Shaun E Gruenbaum, Federico Bilotta
PURPOSE OF REVIEW: This article reviews the recent evidence on perioperative neuroprotection in patients undergoing brain surgery and in patients with acute stroke. RECENT FINDINGS: With varying degrees of success, numerous pharmacological and nonpharmacological therapies have been employed to provide neuroprotection for patients during the perioperative period and after acute ischemic stroke (IAS). Recent studies have failed to demonstrate neuroprotective effects of intraoperative remifentanil or propofol use, although hypertonic saline may provide better brain relaxation than mannitol during elective intracranial surgery for tumor...
October 2015: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/26282667/the-distinct-role-of-nr2b-subunit-in-the-enhancement-of-visual-plasticity-in-adulthood
#18
Hanxiao Liu, Yue Li, Yan Wang, Xinxing Wang, Xu An, Siying Wang, Lin Chen, Guosong Liu, Yupeng Yang
BACKGROUND: Experience-dependent plasticity is confined to the critical period of early postnatal life, and declines dramatically thereafter. This attenuation promotes the stabilization of cortical circuits, but also limits functional recovery of several brain diseases. The cognitive functions and synaptic plasticity in the hippocampus and prefrontal cortex are elevated following chronic magnesium treatment. Here, we explored the effect of magnesium treatment on visual plasticity and the potential clinical significance...
2015: Molecular Brain
https://www.readbyqxmd.com/read/26105410/pp088-oral-antihypertensive-therapy-for-severe-hypertension-in-pregnancy
#19
T Firoz, L A Magee, S Lalani, D Sawchuck, B Payne, M Vidler, R Gordon, P von Dadelszen
INTRODUCTION: The hypertensive disorders of pregnancy are among the leading causes of maternal mortality and morbidity. The vast majority occurs in low and middle income countries. It is widely accepted that women with severe hypertension are at increased risk of stroke and benefit from blood pressure (BP) reduction. Although traditionally, parenteral antihypertensive agents have been studied for treatment of severe hypertension in pregnancy, oral agents would be ideal for use in the community and in under-resourced settings...
July 2012: Pregnancy Hypertension
https://www.readbyqxmd.com/read/26105361/pp039-the-importance-of-intentionally-considering-class-1-hellp-syndrome-outcomes-versus-all-other-categories-of-hellp-syndrome-or-severe-preeclampsia
#20
J N Martin, J M Brewer, P G Blake, M Y Owens, B LaMarca, I Sunesara
INTRODUCTION: Combining HELLP syndrome patient groups in publications and presentations may obfuscate any potential differences among patient groups with regard to maternal-perinatal outcomes and rendered therapies. OBJECTIVES: We explored the prevalence of major maternal morbidity (MMM) for patients with severe preeclampsia (SPRE) and each defined group of HELLP syndrome. METHODS: Retrospective cohort study 2000-2007 of patients categorized either as class 1 HELLP syndrome (HELLP1, platelets⩽50,000, AST⩽70,LDH⩽600), class 2 (HELLP2, platelets>50,000 to ⩽100,000), class 3 (HELLP3, platelets>100,000 to ⩽150,000), or partial/incomplete (HELLP4) with only 2 of 3 diagnostic parameters present...
July 2012: Pregnancy Hypertension
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