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Stefan Schreiber, Daniel C Baumgart, Joost P H Drenth, Rafał S Filip, Lucy B Clayton, Kerry Hylands, Alessandro Repici, Cesare Hassan
BACKGROUND:  Polyethylene glycol (PEG) bowel preparations are widely used for precolonoscopy bowel cleansing. This phase 3 trial assessed the efficacy, safety, and tolerability of the novel 1 L PEG-based NER1006 vs. sodium picosulfate plus magnesium citrate (SP + MC) in day-before dosing. METHODS:  Patients requiring colonoscopy were randomized (1 : 1) to receive NER1006 or SP + MC. Cleansing was assessed on the Harefield Cleansing Scale (HCS) and Boston Bowel Preparation Scale (BBPS) using central readers...
July 19, 2018: Endoscopy
Raf Bisschops, Jonathan Manning, Lucy B Clayton, Richard Ng Kwet Shing, Marco Álvarez-González
BACKGROUND:  Polyethylene glycol (PEG)-based bowel preparations are effective cleansers but many require high-volume intake. This phase 3, randomized, blinded, multicenter, parallel-group, central reader-assessed study assessed the 1 L PEG NER1006 bowel preparation vs. standard 2 L PEG with ascorbate (2LPEG). METHODS:  Patients undergoing colonoscopy were randomized (1:1:1) to receive NER1006, as an evening/morning (N2D) or morning-only (N1D) regimen, or evening/morning 2LPEG...
July 19, 2018: Endoscopy
Ines Weinhold, Sebastian Gurtner
In light of the rising regional inequalities in primary care provider supply, to ensure equitable access is a pressing issue in health policy. Most policy approaches fall short in considering the patient perspective when defining shortage areas. As a consequence, implementations of new service delivery models might fail to be responsive to patients' expectations. To explore regional differences in the relative importance of structure and process attributes as drivers of patient satisfaction with local primary care, we collected data from residents of three objectively well-supplied urban and six objectively worse-supplied rural areas in Germany and tested a multi-group structural equation model...
June 21, 2018: Social Science & Medicine
Amanda Schenatto Ferreira, Danilo de Oliveira Silva, Liliam Barbuglio Del Priore, Carmen Lucia Gomes Garcia, Matheus Henrique Maiolini Ducatti, Ana Flavia Balotari Botta, Marina Cabral Waiteman, Fábio Mícolis de Azevedo
OBJECTIVES: To investigate pain level and function limitation in adolescent athletes and physically active non-athletes with PFP. DESIGN: Cross-sectional study. SETTING: Adolescent athletes were recruited at a sport center complex. Adolescent non-athletes were recruited from upper secondary schools. PARTICIPANTS: 108 adolescents diagnosed with PFP: 42 adolescent athletes and 66 adolescent non-athletes. MAIN OUTCOME MEASURES: To evaluate the level of pain, a visual analog scale (VAS) was used and to evaluate the overall function, the Knee Outcome in Osteoarthritis Survey (KOOS) was used...
July 11, 2018: Physical Therapy in Sport
Margarita Jiménez-Tototzintle, Izabel Jales Ferreira, Sheila da Silva Duque, Paulo Rubens Guimarães Barrocas, Enrico Mendes Saggioro
The dispersion of pollutants and proliferation of antibiotic resistant bacteria in the aquatic environment are an emerging health concern worldwide. In this sense, it is essential to develop new technologies to increase the quality of wastewater treatment, which is spread throughout the environment. The present study has demonstrated evidence of the existence of antibiotic and mercury-resistant bacteria in the aquatic environment. The application of heterogeneous photocatalysis with UVA/TiO2 P25 slurry (200 mg L-1 ), UVA/TiO2 -immobilized, and UVA/TiO2 -immobilized/H2 O2 were evaluated for the simultaneous elimination of a mixture of contaminants of emerging concern (acetamiprid (ACP), imazalil (IMZ) and bisphenol A (BPA)) and inactivation of antibiotic and mercury-resistant bacteria (Pseudomonas aeruginosa and Bacillus subtilis)...
July 11, 2018: Chemosphere
E Hartl, T Knoche, H M P Choupina, J Rémi, C Vollmar, J P S Cunha, S Noachtar
PURPOSE: To investigate the frequency, localizing significance, and intensity characteristics of ictal vocalization in different focal epilepsy syndromes. METHODS: Up to four consecutive focal seizures were evaluated in 277 patients with lesional focal epilepsy, excluding isolated auras and subclinical EEG seizure patterns. Vocalization was considered to be present if observed in at least one of the analyzed seizures and not being of speech quality. Intensity features of ictal vocalization were analyzed in a subsample of 17 patients with temporal and 19 with extratemporal epilepsy syndrome...
July 11, 2018: Seizure: the Journal of the British Epilepsy Association
Nan Zhou, Shiyu Liu, Yaning Zhang, Liangliang Fan, Yanling Cheng, Yunpu Wang, Yuhuan Liu, Paul Chen, Roger Ruan
Considering a series of issues facing the application of catalysts in large scale catalytic fast pyrolysis systems, a novel composite catalyst of ZSM-5 coatings on SiC foam supports was developed and tested for ex-situ catalytic upgrading of the pyrolytic vapors. Different configurations of catalysts placement were compared and the results showed the composite catalyst could significantly improve the bio-oil quality without significantly reducing the yield. The effect of catalyst to biomass ratio on the product yields and bio-oil composition was studied and the results showed that increasing catalyst to biomass ratio could improve the quality of bio-oil at the cost of its yield...
July 4, 2018: Bioresource Technology
Massimiliano Orri, Lea C Perret, Gustavo Turecki, Marie-Claude Geoffroy
BACKGROUND: Irritability is gaining considerable attention as a risk factor for suicide-related outcomes (suicide mortality, attempt, and ideation). However, the evidence of this association is scant. We conducted a systematic review of the evidence regarding the associations between irritability and suicide-related outcomes across the life-course. METHODS: We conducted a systematic search on Medline and PsycINFO (up to January 2018) for original articles published in English investigating the association between irritability and suicide-related outcomes...
July 4, 2018: Journal of Affective Disorders
Brittany E Hayes, Eryn Nicole O'Neal
Knowledge is lacking regarding the extent to which national norms and policies designed to protect minors influence individual attitudes toward child maltreatment. Relying on the tenets of cultural sociology, we examine whether the orientation of a nation influences individual attitudes toward child maltreatment. Specifically, nations with greater economic and political stability tolerate more self-expressive values, focusing on individual autonomy and enhancing quality of life. Conversely, nations with a survivalist orientation, often characterized by greater economic uncertainty, are less supportive of behaviors that may result in further instability...
July 16, 2018: Child Abuse & Neglect
Elena A Zvereva, Anatoly V Zherdev, Andey A Formanovsky, Ramadan A Abuknesha, Sergei A Eremin, Boris B Dzantiev
In this study, a fluorescence polarization immunoassay (FPIA) technique was developed to determine colchicine (COL), an alkaloid of noxious plants of the order Liliales that is used in a number of medications to treat gout. An optimal combination of the polyclonal antibody and the antigen labelled with fluorescein isothiocyanate (FITC) was selected. Conditions for the competitive interaction of the antigen in the tested samples and its fluorophore conjugate (COL-FITC) with anti-COL antibodies were optimised, and the analytical characteristics of the assay were determined...
July 11, 2018: Journal of Pharmaceutical and Biomedical Analysis
Bahia Abbas Moussa, Marianne Alphonse Mahrouse, Michael Gamal Fawzy
To maintain intensive glucose control early in the type II diabetes mellitus process, novel combinations of canagliflozin/metformin (CAG/MEF) and empagliflozin/linagliptin (EMG/LIG) offer particular treatment benefits. In this study, sensitive and precise spectrophotometric methods were developed for the determination of such hypoglycemic drug combinations in bulk powder and in pharmaceutical dosage form without prior separation. The first method was ratio difference coupled with modified isosbestic point technique where the amplitude difference between 239 and 291 nm on the ratio spectrum of CAG obtained using 4 μg/ml of MEF as divisor was used for determination of CAG...
June 20, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Li Lu, Dan-Dan Xu, Huan-Zhong Liu, Ling Zhang, Chee H Ng, Gabor S Ungvari, Feng-Rong An, Yu-Tao Xiang
Internet addiction (IA) is common amongst young people, but no data on IA are available in Tibetan middle school students in China. This study compared the prevalence of IA between Tibetan and Han Chinese middle school students, and examined its association with quality of life. The study was conducted in two middle schools in the Tibetan area of Qinghai province and two Han Chinese middle schools in Anhui province, China. Internet addiction, depressive symptoms and quality of life were measured using standardized instruments...
July 7, 2018: Psychiatry Research
Friederike Erdmann, Tengfei Li, George Luta, Brenda M Giddings, Guillermo Torres Alvarado, Eva Steliarova-Foucher, Joachim Schüz, Ana M Mora
BACKGROUND: Estimating childhood cancer incidence globally is hampered by a lack of reliable data from low- and middle-income countries. Costa Rica is one of the few middle-income countries (MIC) with a long-term high quality nationwide population-based cancer registry. METHODS: Data on incident cancers in children aged under 15 years reported to the Costa Rica National Cancer Registry between 2000 and 2014 were analyzed by diagnostic group, age, sex, and geographical region and compared with incidence data for Hispanic and Non-Hispanic White (NHW) children in California, USA...
July 16, 2018: Cancer Epidemiology
Yi-Xin Wang, Heng-Gui Chen, Xian-Dong Li, Ying-Jun Chen, Chong Liu, Wei Feng, Qiang Zeng, Peng Wang, An Pan, Wen-Qing Lu
Widespread human exposure to vanadium has been well documented. Vanadium exposure was reported to induce male reproductive toxicity in toxicological studies, yet human epidemiologic studies are lacking. Here we determined the associations between environmental exposure to vanadium and semen quality, spermatozoa DNA damage and serum reproductive hormones. Concentrations of vanadium in seminal plasma and repeated urine samples were determined among 764 men recruited from a reproductive medicine centre. Associations of vanadium concentrations with semen quality parameters (n = 764), DNA integrity measures (n = 404) and serum reproductive hormones (n = 381) were assessed by logistic or linear regression models with adjustment for potential confounders...
July 16, 2018: Science of the Total Environment
Marie-Laure Laroche, Marianne Teste, Julien Vanoost, Hélène Geniaux
An inappropriate immunologic response has been suggested to play a role in the pathogenesis of hidradenitis suppurativa (HS). Adalimumab was the first TNF-α inhibitor approved for moderate to severe HS. We report on a case of HS (Hurley stage 2) in a 39-year-old man, who had received fusidic acid and isotretinoin treatments without evident benefit during the last 8 years. The patient noticed a reduction in the number of lesions and quality of life (DLQI from 27 to 6) in the 2 months following verapamil initiation for cluster headache...
July 19, 2018: Fundamental & Clinical Pharmacology
Tara Neubrand, Natasha Cabrera, Stacey Coss, Anthony Watkins, Michael DiStefano
Each year, an average of 16,000 children require cardiopulmonary resuscitation (CPR) for cardiopulmonary arrest in the United States, and their survival is largely dependent on the provision of optimal and timely resuscitation in concordance with current professional guidelines.1,2 As a profession, emergency department (ED) providers regularly perform inadequate resuscitation for children with cardiopulmonary arrest, and the quality of CPR provided for these patients is not in accordance with accepted standards of care...
July 19, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
M Rizzo, K D Ducheyne, C Deelen, M Beitsma, S Cristarella, M Quartuccio, T A E Stout, M de Ruijter-Villani
BACKGROUND: Advanced mare age is associated with declining fertility and an increased risk of early pregnancy loss. Compromised oocyte quality is probably the primary reason for reduced fertility, but the defects predisposing to embryonic death are unknown. In women, advanced age predisposes to chromosome segregation errors during meiosis, which lead to embryonic aneuploidy and a heightened risk of miscarriage. OBJECTIVES: To evaluate the effect of advanced mare age on chromosome alignment and meiotic spindle morphology in in vitro matured (IVM) oocytes...
July 19, 2018: Equine Veterinary Journal
Lilliana Moreno, Michelle Galusha, Rebecca Just
Massively parallel sequencing (MPS) provides forensic DNA laboratories an option to overcome the limitations associated with capillary electrophoresis (CE) and current STR assays. Verogen's MPS ForenseqTM DNA Signature kit concomitantly amplifies 27 autosomal, 7 X-, and 24 Y-STRs. In addition, 94 identity, 56 ancestry, and 22 phenotypic-informative SNPs are included for a total of over 200 markers in one multiplex. An internal validation of this platform was conducted using reference samples to investigate whether the Forenseq™ DNA Signature Prep kit, specifically primer panel B, has the capability to provide consistent and accurate typing/sequencing data...
July 19, 2018: Electrophoresis
France Légaré, Rhéda Adekpedjou, Dawn Stacey, Stéphane Turcotte, Jennifer Kryworuchko, Ian D Graham, Anne Lyddiatt, Mary C Politi, Richard Thomson, Glyn Elwyn, Norbert Donner-Banzhoff
BACKGROUND: Shared decision making (SDM) is a process by which a healthcare choice is made by the patient, significant others, or both with one or more healthcare professionals. However, it has not yet been widely adopted in practice. This is the second update of this Cochrane review. OBJECTIVES: To determine the effectiveness of interventions for increasing the use of SDM by healthcare professionals. We considered interventions targeting patients, interventions targeting healthcare professionals, and interventions targeting both...
July 19, 2018: Cochrane Database of Systematic Reviews
Akira Obana, Yuko Gohto, Hiroyuki Sasano, Werner Gellermann, Mohsen Sharifzadeh, Takahiko Seto, Paul S Bernstein
Purpose: To evaluate the influence of cataracts on measuring macular pigment optical density (MPOD) using a dual-wavelength confocal scanning autofluorescence imaging technique and to establish methods to compensate for the influence of cataracts. Methods: This prospective case series comprised 100 eyes that underwent cataract surgery. Cataracts were graded based on the World Health Organization classification. MPOD levels were measured with the MPOD module of the Spectralis MultiColor instrument (Spectralis-MP), pre- and postoperatively...
June 1, 2018: Investigative Ophthalmology & Visual Science
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