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https://www.readbyqxmd.com/read/28821671/learning-and-stress-shape-the-reward-response-patterns-of-serotonin-neurons
#1
Zhong Weixin, Yi Li, Qiru Feng, Minmin Luo
The ability to predict reward promotes animal survival. Both dopamine neurons in the ventral tegmental area (VTA) and serotonin neurons in the dorsal raphe nucleus (DRN) participate in reward processing. Although the learning effects on dopamine neurons have been extensively characterized, it remains largely unknown how the response of serotonin neurons evolves during learning. Moreover, while stress is known to strongly influence reward-related behavior, we know very little about how stress modulates neuronal reward responses...
August 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28820016/why-we-stay-with-our-social-partners-neural-mechanisms-of-stay-leave-decision-making
#2
Amber Heijne, Filippo Rossi, Alan G Sanfey
How do we decide to keep interacting (e.g., stay) with a social partner or to switch (e.g., leave) to another? This paper investigated the neural mechanisms of stay/leave decision-making. We hypothesized that these decisions fit within a framework of value-based decision-making, and explored four potential mechanisms underlying a hypothesized bias to stay. Twenty-six participants underwent functional Magnetic Resonance Imaging (fMRI) while completing social and nonsocial versions of a stay/leave decision-making task...
August 18, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/28819323/excessive-body-fat-linked-to-blunted-somatosensory-cortex-response-to-general-reward-in-adolescents
#3
J F Navas, A Barros-Loscertales, V Costumero-Ramos, J Verdejo-Román, R Vilar-López, A Verdejo-García
BACKGROUND AND AIMS: The brain reward system is key to understanding adolescent obesity in the current obesogenic environment, rich in highly appetising stimuli, to which adolescents are particularly sensitive. We aimed to examine the association between body fat levels and brain reward system responsivity to general (monetary) rewards in male and female adolescents. METHOD: Sixty-eight adolescents (34 females; mean age [standard deviation]=16.56 [1.35]) were measured for body fat levels with bioelectric impedance, and underwent a functional magnetic resonance imaging (fMRI) scan during the Monetary Incentive Delay (MID) task...
August 18, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28813815/how-do-strength-and-coordination-recovery-interact-after-stroke-a-computational-model-for-informing-robotic-training
#4
Sumner L Norman, Joan Lobo-Prat, David J Reinkensmeyer
Robotic devices can train strength, coordination, or a combination of both. If a robotic device focuses on coordination, what happens to strength recovery, and vice versa? Understanding this interaction could help optimize robotic training. We developed a computational neurorehabilitation model to gain insight into the interaction between strength and coordination recovery after stroke. In the model, the motor system recovers by optimizing the activity of residual corticospinal cells (focally connected, excitatory and inhibitory) and reticulospinal cells (diffusely connected and excitatory) to achieve a motor task...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813432/basic-reversal-learning-capacity-in-flies-suggests-rudiments-of-complex-cognition
#5
Brad R Foley, Paul Marjoram, Sergey V Nuzhdin
The most basic models of learning are reinforcement learning models (for instance, classical and operant conditioning) that posit a constant learning rate; however many animals change their learning rates with experience. This process is sometimes studied by reversing an existing association between cues and rewards, and measuring the rate of relearning. Augmented reversal-learning, where learning rates increase with practice, can be an important component of behavioral flexibility; and may provide insight into higher cognition...
2017: PloS One
https://www.readbyqxmd.com/read/28811178/acute-%C3%AE-9-tetrahydrocannabinol-administration-in-female-rats-attenuates-immediate-responses-following-losses-but-not-multi-trial-reinforcement-learning-from-wins
#6
Scott A Wong, Sienna H Randolph, Victorita E Ivan, Aaron J Gruber
Δ-9-tetrahydrocannabinol (THC) is the main psychoactive component of marijuana and has potent effects on decision-making, including a proposed reduction in cognitive flexibility. We demonstrate here that acute THC administration differentially affects some of the processes that contribute to cognitive flexibility. Specifically, THC reduces lose-shift responding in which female rats tend to immediately shift choice responses away from options that result in reward omission on the previous trial. THC, however, did not impair the ability of rats to flexibly bias responses toward feeders with higher probability of reward in a reversal task...
August 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28808037/separate-mesocortical-and-mesolimbic-pathways-encode-effort-and-reward-learning-signals
#7
Tobias U Hauser, Eran Eldar, Raymond J Dolan
Optimal decision making mandates organisms learn the relevant features of choice options. Likewise, knowing how much effort we should expend can assume paramount importance. A mesolimbic network supports reward learning, but it is unclear whether other choice features, such as effort learning, rely on this same network. Using computational fMRI, we show parallel encoding of effort and reward prediction errors (PEs) within distinct brain regions, with effort PEs expressed in dorsomedial prefrontal cortex and reward PEs in ventral striatum...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28807763/effects-of-2-2-4-4-tetrabromodiphenyl-ether-on-neurobehavior-and-memory-change-and-bcl-2-c-fos-grin1b-and-lingo1b-gene-expression-in-male-zebrafish-danio-rerio
#8
Shukai Zheng, Caixia Liu, Yanhong Huang, Mian Bao, Yuanni Huang, Kusheng Wu
Polybrominated diphenyl ethers (PBDEs) are persistent organic pollutants in various environmental matrices and organisms and pose a threat to neural systems of organisms. However, though quite a few studies have explored the effect of PBDEs on neural behaviors such as learning and memory abilities in animals, their mechanisms are less known. We used the zebrafish model to evaluate neurotoxicity of PBDEs and observe changes in behavior and related gene expression. In behavioral testing, 50 zebrafish were divided into five groups treated with different concentrations of BDE-47...
August 12, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28805428/ventral-striatum-lesions-do-not-affect-reinforcement-learning-with-deterministic-outcomes-on-slow-time-scales
#9
Raquel Vicario-Feliciano, Elisabeth A Murray, Bruno B Averbeck
A large body of work has implicated the ventral striatum (VS) in aspects of reinforcement learning (RL). However, less work has directly examined the effects of lesions in the VS, or other forms of inactivation, on 2-armed bandit RL tasks. We have recently found that lesions in the VS in macaque monkeys affect learning with stochastic schedules but have minimal effects with deterministic schedules. The reasons for this are not currently clear. Because our previous work used short intertrial intervals, one possibility is that the animals were using working memory to bridge stimulus-reward associations from 1 trial to the next...
August 14, 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28804467/learning-about-expectation-violation-from-prediction-error-paradigms-a-meta-analysis-on-brain-processes-following-a-prediction-error
#10
Lisa D'Astolfo, Winfried Rief
Modifying patients' expectations by exposing them to expectation violation situations (thus maximizing the difference between the expected and the actual situational outcome) is proposed to be a crucial mechanism for therapeutic success for a variety of different mental disorders. However, clinical observations suggest that patients often maintain their expectations regardless of experiences contradicting their expectations. It remains unclear which information processing mechanisms lead to modification or persistence of patients' expectations...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28802898/neurochemical-evidence-that-cocaine-and-amphetamine-regulated-transcript-cart-55-102-peptide-modulates-the-dopaminergic-reward-system-by-decreasing-the-dopamine-release-in-the-mouse-nucleus-accumbens
#11
Angelina Rakovska, Maria Baranyi, Katalin Windish, Polina Petkova-Kirova, Hristo Gagov, Reni Kalfin
CART (Cocaine- and Amphetamine-Regulated Transcript) peptide is a neurotransmitter naturally occurring in the CNS and found mostly in nucleus accumbens, ventrotegmental area, ventral pallidum, amygdalae and striatum, brain regions associated with drug addiction. In the nucleus accumbens, known for its significant role in motivation, pleasure, reward and reinforcement learning, CART peptide inhibits cocaine and amphetamine-induced dopamine-mediated increases in locomotor activity and behavior, suggesting a CART peptide interaction with the dopaminergic system...
August 9, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28801372/multi-variant-genetic-panel-for-genetic-risk-of-opioid-addiction
#12
Keri Donaldson, Laurence Demers, Kirk Taylor, Joe Lopez, Sherman Chang
Over 116 million people worldwide have chronic pain and prescription dependence. In the US, opioids account for the majority of overdose deaths, and in 2014, almost 2 million Americans abused or were dependent on prescription opioids. Genetic factors may play a key role in opioid prescription addiction. Herein, we describe genetic variations between opioid addicted and non-addicted populations and derive a predictive model determining risk of opioid addiction. This case cohort study compares the frequency of 16 single nucleotide polymorphisms involved in the brain reward pathways in patients with and without opioid addiction...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28798918/learning-and-judgment-can-be-affected-by-predisposed-fearfulness-in-laying-hens
#13
Elske N de Haas, Caroline Lee, T Bas Rodenburg
High fearfulness could disrupt learning and likely affects judgment in animals, especially when it is part of an animals' personality, i.e., trait anxiety. Here, we tested whether high fearfulness affects discrimination learning and judgment bias (JB) in laying hens. Based on the response to an open field at 5 weeks of age, birds were categorized as fearful (FC) by showing no walking or vocalizing or non-fearful (NFC) by showing walking and vocalizing. At adult age, birds (n = 24) were trained in a go-go task to discriminate two cues (white or black) with a small or large reward...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28797600/the-rat-retrosplenial-cortex-as-a-link-for-frontal-functions-a-lesion-analysis
#14
Anna L Powell, Andrew Nelson, Emma Hindley, Moira Davies, John P Aggleton, Seralynne D Vann
Cohorts of rats with excitotoxic retrosplenial cortex lesions were tested on four behavioural tasks sensitive to dysfunctions in prelimbic cortex, anterior cingulate cortex, or both. In this way the study tested whether retrosplenial cortex has nonspatial functions that reflect its anatomical interactions with these frontal cortical areas. In Experiment 1, retrosplenial cortex lesions had no apparent effect on a set-shifting digging task that taxed intradimensional and extradimensional attention, as well as reversal learning...
August 7, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28792570/-the-global-model-of-public-mental-health-and-recovery-mentors
#15
Jean-François Pelletier, Émilie Auclair
Objectives The aim of this paper is to revisit the Global Model of Public Mental Health (GMPMH) in light of the 4th Civic Forum. Recovery mentors of the University of Recovery chaired this public event, which was held in East-end Montreal, Canada, in 2016. The University of Recovery is a concept of co-learning among its members.Methods Being able to refer to international conventions and human rights standards is a key component of a genuine global approach that is supportive of individuals and communities in their quest for recovery and full citizenship...
2017: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/28792447/ambiguous-results-when-using-the-ambiguous-cue-paradigm-to-assess-learning-and-cognitive-bias-in-gorillas-and-a-black-bear
#16
Molly C McGuire, Jennifer Vonk, Zoe Johnson-Ulrich
Cognitive bias tests are frequently used to assess affective state in nonhumans. We adapted the ambiguous-cue paradigm to assess affective states and to compare learning of reward associations in two distantly related species, an American black bear and three Western lowland gorillas. Subjects were presented with three training stimuli: one that was always rewarded (P), one that was never rewarded (N) and one that was ambiguous (A) because its reward association depended on whether it had been paired with P (PA pairing) or N (NA pairing)...
August 9, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28791553/sex-differences-in-discrimination-reversal-learning-in-the-guppy
#17
Maria Elena Miletto Petrazzini, Angelo Bisazza, Christian Agrillo, Tyrone Lucon-Xiccato
In several mammalian and avian species, females show a higher performance than males in tasks requiring cognitive flexibility such as the discrimination reversal learning. A recent study showed that female guppies are twice as efficient as males in a reversal learning task involving yellow-red discrimination, suggesting a higher cognitive flexibility in female guppies. However, the possibility exists that the superior performance exhibited by females does not reflect a general sex difference in cognitive abilities, but instead, is confined to colour discrimination tasks...
August 8, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28790900/maladaptive-decision-making-in-adults-with-a-history-of-adolescent-alcohol-use-in-a-preclinical-model-is-attributable-to-the-compromised-assignment-of-incentive-value-during-stimulus-reward-learning
#18
Lauren C Kruse, Abigail G Schindler, Rapheal G Williams, Sophia J Weber, Jeremy J Clark
According to recent WHO reports, alcohol remains the number one substance used and abused by adolescents, despite public health efforts to curb its use. Adolescence is a critical period of biological maturation where brain development, particularly the mesocorticolimbic dopamine system, undergoes substantial remodeling. These circuits are implicated in complex decision making, incentive learning and reinforcement during substance use and abuse. An appealing theoretical approach has been to suggest that alcohol alters the normal development of these processes to promote deficits in reinforcement learning and decision making, which together make individuals vulnerable to developing substance use disorders in adulthood...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28790898/differences-between-dorsal-and-ventral-striatum-in-the-sensitivity-of-tonically-active-neurons-to-rewarding-events
#19
Kevin Marche, Anne-Caroline Martel, Paul Apicella
Within the striatum, cholinergic interneurons, electrophysiologically identified as tonically active neurons (TANs), represent a relatively homogeneous group in terms of their functional properties. They display typical pause in tonic firing in response to rewarding events which are of crucial importance for reinforcement learning. These responses are uniformly distributed throughout the dorsal striatum (i.e., motor and associative striatum), but it is unknown, at least in monkeys, whether differences in the modulation of TAN activity exist in the ventral striatum (i...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28789870/relevance-of-the-nucleus-of-the-solitary-tract-gelatinous-part-in-learned-preferences-induced-by-intragastric-nutrient-administration
#20
María A Zafra, Antonio D Agüera, Filomena Molina, Amadeo Puerto
Food preferences have been investigated in Wistar rats utilizing a learned concurrent flavor preference behavioral procedure. Previous studies have demonstrated that the perivagal administration of neurotoxin capsaicin disrupts the learning of preferences induced by intragastric administration of rewarding nutrients (pre-digested milk). The vagus nerve projects almost exclusively towards the nucleus of the solitary tract (NST), a brain medullary gateway for visceral signals. The objective of this study was to investigate the participation of the lateral portion of the dorsomedial region, the gelatinous subnucleus (SolG), in the learning of a concurrent preference task...
August 5, 2017: Appetite
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