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JOURNAL ARTICLE
María Nieves Saez Perdomo, Ruth Stuckey, Elena González-Pérez, Santiago Sánchez-Sosa, Paula Estupiñan-Cabrera, Sunil Lakhwani Lakhwani, José David González San Miguel, Nuria Hernanz Soler, Marina Gordillo, Gloria González Brito, María Tapia-Torres, Ana Ruano, Adrián Segura-Díaz, Hugo Luzardo, Cristina Bilbao-Sieyro, María Teresa Gómez-Casares
BACKGROUND: Second- and third-generation tyrosine kinase inhibitors (TKIs) are now available to treat chronic-phase chronic myeloid leukemia (CP-CML) in the first and second line. However, vascular adverse events (VAEs) have been reported for patients with CML treated with some TKIs. METHODS: We retrospectively evaluated the cumulative incidence (CI) and cardiovascular risk for 210 patients included in the Canarian Registry of CML. RESULT: With a mean follow up of 6 years, 19/210 (9...
March 12, 2024: Hematology Reports
#2
JOURNAL ARTICLE
Jorge Adolfo Poot-Franco, Anuar Mena-Balan, Adrian Perez-Navarrete, Osvaldo Huchim, Hugo Azcorra-Perez, Nina Mendez-Dominguez
We aimed to analyze the association between the average lumbar subcutaneous fat tissue thickness (LSFTT) at each intervertebral level and the presence of hernias in patients with low back pain from an insurance network hospital in Mexico. This observational prospective study included 174 patients with non-traumatic lumbago who underwent magnetic resonance imaging with a 1.5T resonator. Two independent radiologists made the diagnosis, and a third specialist provided a quality vote when needed. The sample size was calculated with a 95% confidence interval using random order selection...
February 13, 2024: Tomography: a Journal for Imaging Research
#3
JOURNAL ARTICLE
Raquel B Ferioli, Amanda R da Mata, Angélica M Sánchez-Sarmiento, Melissa Marcon, Karina K Marques da Costa Flaiban, Pedro Castilho, Cristiane K M Kolesnikovas, Adriane Steuernagel, Giulia G Lemos, Camila Domit, Renata L Soares, Maria C L Alvarez, Rodrigo Del Rio do Valle, Andrea Maranho, Anneliese C Kyllar, Hugo G Neto, Carla B Barbosa
Complete blood counts (n=566) and serum biochemistry (n=426) were assessed in seven coastal seabirds species that underwent rehabilitation along the southeastern and southern coast of Brazil from Saquarema, Rio de Janeiro State (22°56'16.44″S, 42°18'24.16″W) to Laguna, Santa Catarina State (28°29'43″S, 48°45'39.2″W), from August 2016 to August 2020. Blood samples were collected from four species of Charadriiformes, including Kelp Gull (Larus dominicanus, n=136), South American Tern (Sterna hirundinacea, n=25), Cabot's Tern (Thalasseus acuflavidus, n=17), and Common Tern (Sterna hirundo, n=14) as well as three species of Suliformes, the Brown Booby (Sula leucogaster, n=212), Magnificent Frigatebird (Fregata magnificens, n=104), and Neotropic Cormorant (Nannopterum brasilianum, n=58)...
February 12, 2024: Journal of Wildlife Diseases
#4
JOURNAL ARTICLE
Laurent Truche, Frédéric-Victor Donzé, Edmond Goskolli, Bardhyl Muceku, Corinne Loisy, Christophe Monnin, Hugo Dutoit, Adrian Cerepi
Deep crustal production of hydrogen (H2 ) is a potential source of primary energy if recoverable accumulations in geological formations are sufficiently large. We report direct measurements of an elevated outgassing rate of 84% (by volume) of H2 from the deep underground Bulqizë chromite mine in Albania. A minimum of 200 tons of H2 is vented annually from the mine's galleries, making it one of the largest recorded H2 flow rates to date. We cannot attribute the flux solely to the release of paleo-fluids trapped within the rocks or to present-day active and pervasive serpentinization of ultramafic rocks; rather, our results demonstrate the presence of a faulted reservoir deeply rooted in the Jurassic ophiolite massif...
February 9, 2024: Science
#5
JOURNAL ARTICLE
Addressing climate change with behavioral science: A global intervention tournament in 63 countries.
Madalina Vlasceanu, Kimberly C Doell, Joseph B Bak-Coleman, Boryana Todorova, Michael M Berkebile-Weinberg, Samantha J Grayson, Yash Patel, Danielle Goldwert, Yifei Pei, Alek Chakroff, Ekaterina Pronizius, Karlijn L van den Broek, Denisa Vlasceanu, Sara Constantino, Michael J Morais, Philipp Schumann, Steve Rathje, Ke Fang, Salvatore Maria Aglioti, Mark Alfano, Andy J Alvarado-Yepez, Angélica Andersen, Frederik Anseel, Matthew A J Apps, Chillar Asadli, Fonda Jane Awuor, Flavio Azevedo, Piero Basaglia, Jocelyn J Bélanger, Sebastian Berger, Paul Bertin, Michał Białek, Olga Bialobrzeska, Michelle Blaya-Burgo, Daniëlle N M Bleize, Simen Bø, Lea Boecker, Paulo S Boggio, Sylvie Borau, Björn Bos, Ayoub Bouguettaya, Markus Brauer, Cameron Brick, Tymofii Brik, Roman Briker, Tobias Brosch, Ondrej Buchel, Daniel Buonauro, Radhika Butalia, Héctor Carvacho, Sarah A E Chamberlain, Hang-Yee Chan, Dawn Chow, Dongil Chung, Luca Cian, Noa Cohen-Eick, Luis Sebastian Contreras-Huerta, Davide Contu, Vladimir Cristea, Jo Cutler, Silvana D'Ottone, Jonas De Keersmaecker, Sarah Delcourt, Sylvain Delouvée, Kathi Diel, Benjamin D Douglas, Moritz A Drupp, Shreya Dubey, Jānis Ekmanis, Christian T Elbaek, Mahmoud Elsherif, Iris M Engelhard, Yannik A Escher, Tom W Etienne, Laura Farage, Ana Rita Farias, Stefan Feuerriegel, Andrej Findor, Lucia Freira, Malte Friese, Neil Philip Gains, Albina Gallyamova, Sandra J Geiger, Oliver Genschow, Biljana Gjoneska, Theofilos Gkinopoulos, Beth Goldberg, Amit Goldenberg, Sarah Gradidge, Simone Grassini, Kurt Gray, Sonja Grelle, Siobhán M Griffin, Lusine Grigoryan, Ani Grigoryan, Dmitry Grigoryev, June Gruber, Johnrev Guilaran, Britt Hadar, Ulf J J Hahnel, Eran Halperin, Annelie J Harvey, Christian A P Haugestad, Aleksandra M Herman, Hal E Hershfield, Toshiyuki Himichi, Donald W Hine, Wilhelm Hofmann, Lauren Howe, Enma T Huaman-Chulluncuy, Guanxiong Huang, Tatsunori Ishii, Ayahito Ito, Fanli Jia, John T Jost, Veljko Jovanović, Dominika Jurgiel, Ondřej Kácha, Reeta Kankaanpää, Jaroslaw Kantorowicz, Elena Kantorowicz-Reznichenko, Keren Kaplan Mintz, Ilker Kaya, Ozgur Kaya, Narine Khachatryan, Anna Klas, Colin Klein, Christian A Klöckner, Lina Koppel, Alexandra I Kosachenko, Emily J Kothe, Ruth Krebs, Amy R Krosch, Andre P M Krouwel, Yara Kyrychenko, Maria Lagomarsino, Claus Lamm, Florian Lange, Julia Lee Cunningham, Jeffrey Lees, Tak Yan Leung, Neil Levy, Patricia L Lockwood, Chiara Longoni, Alberto López Ortega, David D Loschelder, Jackson G Lu, Yu Luo, Joseph Luomba, Annika E Lutz, Johann M Majer, Ezra Markowitz, Abigail A Marsh, Karen Louise Mascarenhas, Bwambale Mbilingi, Winfred Mbungu, Cillian McHugh, Marijn H C Meijers, Hugo Mercier, Fenant Laurent Mhagama, Katerina Michalakis, Nace Mikus, Sarah Milliron, Panagiotis Mitkidis, Fredy S Monge-Rodríguez, Youri L Mora, David Moreau, Kosuke Motoki, Manuel Moyano, Mathilde Mus, Joaquin Navajas, Tam Luong Nguyen, Dung Minh Nguyen, Trieu Nguyen, Laura Niemi, Sari R R Nijssen, Gustav Nilsonne, Jonas P Nitschke, Laila Nockur, Ritah Okura, Sezin Öner, Asil Ali Özdoğru, Helena Palumbo, Costas Panagopoulos, Maria Serena Panasiti, Philip Pärnamets, Mariola Paruzel-Czachura, Yuri G Pavlov, César Payán-Gómez, Adam R Pearson, Leonor Pereira da Costa, Hannes M Petrowsky, Stefan Pfattheicher, Nhat Tan Pham, Vladimir Ponizovskiy, Clara Pretus, Gabriel G Rêgo, Ritsaart Reimann, Shawn A Rhoads, Julian Riano-Moreno, Isabell Richter, Jan Philipp Röer, Jahred Rosa-Sullivan, Robert M Ross, Anandita Sabherwal, Toshiki Saito, Oriane Sarrasin, Nicolas Say, Katharina Schmid, Michael T Schmitt, Philipp Schoenegger, Christin Scholz, Mariah G Schug, Stefan Schulreich, Ganga Shreedhar, Eric Shuman, Smadar Sivan, Hallgeir Sjåstad, Meikel Soliman, Katia Soud, Tobia Spampatti, Gregg Sparkman, Ognen Spasovski, Samantha K Stanley, Jessica A Stern, Noel Strahm, Yasushi Suko, Sunhae Sul, Stylianos Syropoulos, Neil C Taylor, Elisa Tedaldi, Gustav Tinghög, Luu Duc Toan Huynh, Giovanni Antonio Travaglino, Manos Tsakiris, İlayda Tüter, Michael Tyrala, Özden Melis Uluğ, Arkadiusz Urbanek, Danila Valko, Sander van der Linden, Kevin van Schie, Aart van Stekelenburg, Edmunds Vanags, Daniel Västfjäll, Stepan Vesely, Jáchym Vintr, Marek Vranka, Patrick Otuo Wanguche, Robb Willer, Adrian Dominik Wojcik, Rachel Xu, Anjali Yadav, Magdalena Zawisza, Xian Zhao, Jiaying Zhao, Dawid Żuk, Jay J Van Bavel
Effectively reducing climate change requires marked, global behavior change. However, it is unclear which strategies are most likely to motivate people to change their climate beliefs and behaviors. Here, we tested 11 expert-crowdsourced interventions on four climate mitigation outcomes: beliefs, policy support, information sharing intention, and an effortful tree-planting behavioral task. Across 59,440 participants from 63 countries, the interventions' effectiveness was small, largely limited to nonclimate skeptics, and differed across outcomes: Beliefs were strengthened mostly by decreasing psychological distance (by 2...
February 9, 2024: Science Advances
#6
Kaiyuan Yang, Fabio Musio, Yihui Ma, Norman Juchler, Johannes C Paetzold, Rami Al-Maskari, Luciano Höher, Hongwei Bran Li, Ibrahim Ethem Hamamci, Anjany Sekuboyina, Suprosanna Shit, Houjing Huang, Diana Waldmannstetter, Florian Kofler, Fernando Navarro, Martin Menten, Ivan Ezhov, Daniel Rueckert, Iris Vos, Ynte Ruigrok, Birgitta Velthuis, Hugo Kuijf, Julien Hämmerli, Catherine Wurster, Philippe Bijlenga, Laura Westphal, Jeroen Bisschop, Elisa Colombo, Hakim Baazaoui, Andrew Makmur, James Hallinan, Bene Wiestler, Jan S Kirschke, Roland Wiest, Emmanuel Montagnon, Laurent Letourneau-Guillon, Adrian Galdran, Francesco Galati, Daniele Falcetta, Maria A Zuluaga, Chaolong Lin, Haoran Zhao, Zehan Zhang, Sinyoung Ra, Jongyun Hwang, Hyunjin Park, Junqiang Chen, Marek Wodzinski, Henning Müller, Pengcheng Shi, Wei Liu, Ting Ma, Cansu Yalçin, Rachika E Hamadache, Joaquim Salvi, Xavier Llado, Uma Maria Lal-Trehan Estrada, Valeriia Abramova, Luca Giancardo, Arnau Oliver, Jialu Liu, Haibin Huang, Yue Cui, Zehang Lin, Yusheng Liu, Shunzhi Zhu, Tatsat R Patel, Vincent M Tutino, Maysam Orouskhani, Huayu Wang, Mahmud Mossa-Basha, Chengcheng Zhu, Maximilian R Rokuss, Yannick Kirchhoff, Nico Disch, Julius Holzschuh, Fabian Isensee, Klaus Maier-Hein, Yuki Sato, Sven Hirsch, Susanne Wegener, Bjoern Menze
The Circle of Willis (CoW) is an important network of arteries connecting major circulations of the brain. Its vascular architecture is believed to affect the risk, severity, and clinical outcome of serious neuro-vascular diseases. However, characterizing the highly variable CoW anatomy is still a manual and time-consuming expert task. The CoW is usually imaged by two angiographic imaging modalities, magnetic resonance angiography (MRA) and computed tomography angiography (CTA), but there exist limited public datasets with annotations on CoW anatomy, especially for CTA...
December 29, 2023: ArXiv
#7
JOURNAL ARTICLE
Lourdes Carrera-Beltrán, Irene Gavilanes-Terán, Julio Idrovo-Novillo, Victor Hugo Valverde, Adrián Rodríguez-Pinos, Concepción Paredes, Antonio J Signes-Pastor, Ángel A Carbonell-Barrachina
Volcanic eruptions can have long-lasting negative effects on nearby environments and communities, especially those relying on agriculture. The Tungurahua and Sangay volcanoes in Ecuador's highlands pose a significant risk to the region's agricultural economy and inhabitants. The most recent eruption of the Tungurahua volcano spanned from September 1999 to March 2016. Volcanic ash is known to contain both non-essential and essential elements for plant growth, but excessive amounts of the latter can also be toxic and disrupt physiological processes...
January 3, 2024: Ecotoxicology and Environmental Safety
#8
JOURNAL ARTICLE
Hayley McKenzie, Deborah Scott, Adrian C Bateman, Hugo De La Pena Gomez
We present a case of pulmonary tumour thrombotic microangiopathy (PTTM) in a patient on adjuvant immunotherapy for resected triple negative breast cancer. The patient presented with deranged liver function tests and subsequently developed severe hypoxia and thrombocytopaenia, with right heart failure. The primary differential diagnosis considered was immunotherapy-associated hepatitis and pneumonitis. Despite organ support, the patient deteriorated rapidly and died of respiratory failure. As is often the case with PTTM, the diagnosis was only found at postmortem...
September 28, 2023: BMJ Case Reports
#9
JOURNAL ARTICLE
Nicolás Francisco Fernández-Martínez, Mario Rivera-Izquierdo, Rocío Ortiz-González-Serna, Virginia Martínez-Ruiz, Pablo Lardelli-Claret, Adrián Hugo Aginagalde-Llorente, María Del Carmen Valero-Ubierna, María Auxiliadora Vergara-Díaz, Nicola Lorusso
BackgroundMultidrug-resistant (MDR) bacteria are among chief causes of healthcare-associated infections (HAIs). In Spain, studies addressing multidrug resistance based on epidemiological surveillance systems are lacking.AimIn this observational study, cases of HAIs by MDR bacteria notified to the epidemiological surveillance system of Andalusia, Spain, between 2014-2021, were investigated. Notified cases and their spatiotemporal distribution were described, with a focus on social determinants of health (SDoH)...
September 2023: Euro Surveillance
#10
JOURNAL ARTICLE
Jorge Velazquez-Roman, Uriel A Angulo-Zamudio, Nidia Leon-Sicairos, Hector Flores-Villaseñor, Miriam Benitez-Baez, Ana Espinoza-Salomón, Alejandra Karam-León, Hugo Villamil-Ramírez, Samuel Canizales-Quinteros, Luis Macías-Kauffer, Jose Monroy-Higuera, Erika Acosta-Smith, Adrian Canizalez-Roman
UNLABELLED: Metabolic diseases, including obesity, diabetes, and metabolic syndrome, are among the most important public health challenges worldwide. Metabolic diseases are classified as multifactorial diseases in which genetic variants such as single-nucleotide polymorphisms (SNPs) may play an important role. The present study aimed to identify associations linking allelic variants of the PCSK1 , TMEM18 , GPX5 , ZPR1 , ZBTB16 , and PPARG1 genes with anthropometric and biochemical traits and metabolic diseases (obesity or metabolic syndrome) in an adult population from northwestern Mexico...
September 8, 2023: Genes
#11
Roberta Esposito, Andrés Lanzós, Tina Uroda, Sunandini Ramnarayanan, Isabel Büchi, Taisia Polidori, Hugo Guillen-Ramirez, Ante Mihaljevic, Bernard Mefi Merlin, Lia Mela, Eugenio Zoni, Lusine Hovhannisyan, Finn McCluggage, Matúš Medo, Giulia Basile, Dominik F Meise, Sandra Zwyssig, Corina Wenger, Kyriakos Schwarz, Adrienne Vancura, Núria Bosch-Guiteras, Álvaro Andrades, Ai Ming Tham, Michaela Roemmele, Pedro P Medina, Adrian F Ochsenbein, Carsten Riether, Marianna Kruithof-de Julio, Yitzhak Zimmer, Michaela Medová, Deborah Stroka, Archa Fox, Rory Johnson
No abstract text is available yet for this article.
September 6, 2023: Nature Communications
#12
JOURNAL ARTICLE
Catalina Dumitrascu, Celine Gys, Sarah M R Wille, Maria Del Mar Ramiréz-Fernandéz, Diona D'Hondt, Alexia Van Goethem, Babette Van Rafelghem, Eline Baetens, Werner Jacobs, Hugo Neels, Adrian Covaci, Alexander L N van Nuijs
Monitoring long-term alcohol use and/or abstinence is essential in clinical and medico-legal cases. Analysis of ethyl glucuronide (EtG) in hair provides information on alcohol consumption over several months. However, there is a lag time between ethanol consumption, incorporation of EtG in the hair bulb and hair growing out of the scalp. Phosphatidylethanol (PEth) 16:0/18:1 analysis in whole blood has a detection window of 2-4 weeks, allowing for the detection of recent alcohol consumption. In this study, 2340 paired samples (of hair and venous whole blood from 1170 individuals) were analysed for EtG in hair (hEtG) and PEth 16:0/18:1 in venous whole blood...
July 28, 2023: Drug Testing and Analysis
#13
JOURNAL ARTICLE
Marcos Valiente Fernández, Carlos García Fuentes, Francisco de Paula Delgado Moya, Adrián Marcos Morales, Hugo Fernández Hervás, Jesús Abelardo Barea Mendoza, Carolina Mudarra Reche, Susana Bermejo Aznárez, Reyes Muñoz Calahorro, Laura López García, Fernando Monforte Escobar, Mario Chico Fernández
OBJECTIVE: Comparison of the predictive ability of various machine learning algorithms (MLA) versus traditional prediction scales (TPS) for massive hemorrhage (MH) in patients with severe traumatic injury (STI). DESIGN: On a database of a retrospective cohort with prehospital clinical variables and MH outcome, a treatment of the database was performed to be able to apply the different AML, obtaining a total set of 473 patients (80% training, 20% validation). For modeling, proportional imputation and cross validation were performed...
July 26, 2023: Medicina intensiva
#14
JOURNAL ARTICLE
Cecilia Castro-López, Alfonso García-Galaz, Hugo S García, Aarón F González-Córdova, Belinda Vallejo-Cordoba, Adrián Hernández-Mendoza
The biosafety of four potentially probiotic lactobacilli strains, isolated from artisanal Mexican Cocido cheese, was assessed through in vitro tests aimed to determine (1) the antibiotic susceptibility profile by broth microdilution, (2) the transferability of antibiotic resistance determinants by filter-mating, and (3) the phenotypic and genotypic stability during serial batch sub-culture (100-day period) by evaluating physiological and probiotic features and RAPD-PCR fingerprinting. Lactobacilli strains exhibited multidrug-resistance; however, resistance determinants were not transferred in the filter-mating assay...
July 14, 2023: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
#15
JOURNAL ARTICLE
Gabriela Angeles de Paz, Hugo Martínez-Gutierrez, Adrián Ramírez-Granillo, Edgar Oliver López-Villegas, María Gabriela Medina-Canales, Aída Verónica Rodríguez-Tovar
Microorganisms showed unique mechanisms to resist and detoxify harmful metals in response to pollution. This study shows the relationship between presence of heavy metals and plant growth regulator compounds. Additionally, the responses of Rhodotorula mucilaginosa YR29 isolated from the rhizosphere of Prosopis sp. growing in a polluted mine jal in Mexico are presented. This research carries out a phenotypic characterization of R. mucilaginosa to identify response mechanisms to metals and confirm its potential as a bioremediation agent...
July 1, 2023: World Journal of Microbiology & Biotechnology
#16
JOURNAL ARTICLE
Macario Martínez-Castillo, Laura Gómez-Romero, Hugo Tovar, Irma Olarte-Carrillo, Anel García-Laguna, Gilberto Barranco-Lampón, Adrián De la Cruz-Rosas, Adolfo Martínez-Tovar, Araceli Hernández-Zavala, Emilio J Córdova
Use of the potent tyrosine kinase inhibitor imatinib as the first-line treatment in chronic myeloid leukemia (CML) has decreased mortality from 20% to 2%. Approximately 30% of CML patients experience imatinib resistance, however, largely because of point mutations in the kinase domain of the BCR-ABL1 fusion gene. The aim of this study was to use next-generation sequencing (NGS) to identify mutations related to imatinib resistance. The study included 22 patients diagnosed with CML and experiencing no clinical response to imatinib...
May 24, 2023: Leukemia Research
#17
JOURNAL ARTICLE
Roberta Esposito, Andrés Lanzós, Tina Uroda, Sunandini Ramnarayanan, Isabel Büchi, Taisia Polidori, Hugo Guillen-Ramirez, Ante Mihaljevic, Bernard Mefi Merlin, Lia Mela, Eugenio Zoni, Lusine Hovhannisyan, Finn McCluggage, Matúš Medo, Giulia Basile, Dominik F Meise, Sandra Zwyssig, Corina Wenger, Kyriakos Schwarz, Adrienne Vancura, Núria Bosch-Guiteras, Álvaro Andrades, Ai Ming Tham, Michaela Roemmele, Adrian F Ochsenbein, Carsten Riether, Marianna Kruithof-de Julio, Yitzhak Zimmer, Michaela Medová, Deborah Stroka, Archa Fox, Rory Johnson
Long noncoding RNAs (lncRNAs) are linked to cancer via pathogenic changes in their expression levels. Yet, it remains unclear whether lncRNAs can also impact tumour cell fitness via function-altering somatic "driver" mutations. To search for such driver-lncRNAs, we here perform a genome-wide analysis of fitness-altering single nucleotide variants (SNVs) across a cohort of 2583 primary and 3527 metastatic tumours. The resulting 54 mutated and positively-selected lncRNAs are significantly enriched for previously-reported cancer genes and a range of clinical and genomic features...
June 8, 2023: Nature Communications
#18
JOURNAL ARTICLE
José Iván Robles-Torres, Luis Roberto García-Chairez, Daniele Castellani, Joana Valeria Enrriquez-Ávila, Juan Francisco Monzón-Falconi, Antonio Esqueda-Mendoza, Juan Pablo Flores-Tapia, Marcelo Langer Wroclawski, Hugo Octaviano Duarte-Santos, Deepak Ragoori, Nariman Gadzhiev, Abhay Mahajan, Santosh Kumar, Mudasir Farooq, Arvind Ganpule, Yiloren Tanidir, Pankaj Nandkishore Maheshwari, Venkat Arjunrao Gite, Mriganka Mani Sinha, Bhaskar K Somani, Adrián Gutiérrez-González, Vineet Gauhar
PURPOSE: To determine the risk factors associated with major complications in patients with histologically confirmed Xanthogranulomatous pyelonephritis (XGP) who underwent nephrectomy. METHODS: A multicenter retrospective study was performed including patients who underwent nephrectomy between 2018 and 2022 with histopathological diagnosis of XGP. Clinical and laboratory parameters at the initial presentation were evaluated. Data on extension of XGP was recorded as per the Malek clinical-radiological classification...
May 12, 2023: World Journal of Urology
#19
Sophie E Waller, Laura Williams, Adrian Y S Lee, Ming-Wei Lin, Elizabeth McCusker, Hugo Morales-Briceño, Victor S C Fung
No abstract text is available yet for this article.
April 2023: Movement Disorders Clinical Practice
#20
JOURNAL ARTICLE
Christopher Abbosh, Alexander M Frankell, Thomas Harrison, Judit Kisistok, Aaron Garnett, Laura Johnson, Selvaraju Veeriah, Mike Moreau, Adrian Chesh, Tafadzwa L Chaunzwa, Jakob Weiss, Morgan R Schroeder, Sophia Ward, Kristiana Grigoriadis, Aamir Shahpurwalla, Kevin Litchfield, Clare Puttick, Dhruva Biswas, Takahiro Karasaki, James R M Black, Carlos Martínez-Ruiz, Maise Al Bakir, Oriol Pich, Thomas B K Watkins, Emilia L Lim, Ariana Huebner, David A Moore, Nadia Godin-Heymann, Anne L'Hernault, Hannah Bye, Aaron Odell, Paula Roberts, Fabio Gomes, Akshay J Patel, Elizabeth Manzano, Crispin T Hiley, Nicolas Carey, Joan Riley, Daniel E Cook, Darren Hodgson, Daniel Stetson, J Carl Barrett, Roderik M Kortlever, Gerard I Evan, Allan Hackshaw, Robert D Daber, Jacqui A Shaw, Hugo J W L Aerts, Abel Licon, Josh Stahl, Mariam Jamal-Hanjani, Nicolai J Birkbak, Nicholas McGranahan, Charles Swanton
Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells persisting after curative intent therapy1 . The study of large patient cohorts incorporating longitudinal plasma sampling and extended follow-up is required to determine the role of ctDNA as a phylogenetic biomarker of relapse in early-stage non-small-cell lung cancer (NSCLC). Here we developed ctDNA methods tracking a median of 200 mutations identified in resected NSCLC tissue across 1,069 plasma samples collected from 197 patients enrolled in the TRACERx study2 ...
April 13, 2023: Nature
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