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Hugo adrian

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https://www.readbyqxmd.com/read/28210927/efficacy-and-safety-of-daclatasvir-plus-pegylated-interferon-alfa-2a-and-ribavirin-in-previously-untreated-hcv-subjects-coinfected-with-hiv-and-hcv-genotype-1-a-phase-iii-open-label-study
#1
Mark S Sulkowski, Walford J Fessel, Adriano Lazzarin, Juan Berenguer, Natalia Zakharova, Hugo Cheinquer, Pierre Côté, Douglas Dieterich, Adrian Gadano, Gail Matthews, Jean-Michel Molina, Christophe Moreno, Juan Antonio Pineda, Federico Pulido, Antonio Rivero, Jurgen Rockstroh, Dennis Hernandez, Fiona McPhee, Timothy Eley, Zhaohui Liu, Patricia Mendez, Eric Hughes, Stephanie Noviello, Peter Ackerman
BACKGROUND: Daclatasvir (DCV) is a potent, pangenotypic, hepatitis C virus (HCV) non-structural protein 5A inhibitor with low potential for drug interactions with antiretroviral therapy (ART). We evaluated the safety and efficacy of DCV plus peginterferon alfa-2a/ribavirin (PegIFN/RBV) in HIV-1/HCV genotype-1-coinfected patients. METHODS: AI444043 (NCT01471574), an open-label, Phase III, single-arm, response-guided treatment (RGT) study included 301 patients. They received DCV doses of 30, 60 or 90 mg once daily (depending on concomitant ART), plus weight-based RBV (<75 kg, 1000 mg/day; or ≥75 kg, 1200 mg/day), and once-weekly PegIFN 180 μg, for 24 weeks...
February 16, 2017: Hepatology International
https://www.readbyqxmd.com/read/28210823/non-ablative-erbium-yag-laser-for-the-treatment-of-type-iii-stress-urinary-incontinence-intrinsic-sphincter-deficiency
#2
Adrian Gaspar, Hugo Brandi
The objective of this pilot study was to determine the safety and efficacy of a new non-ablative erbium YAG laser procedure for the treatment of type III stress urinary incontinence (intrinsic sphincter deficiency) in women. Twenty-two patients with a Valsalva leak point pressure less than 60 cm H2O were recruited and treated with a non-ablative erbium laser delivering low fluence pulses inside the whole length of the urethra through a specially designed cannula. Treatment consisted of two treatment sessions with a 3-week interval in-between...
February 16, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28193352/a-straightforward-validated-liquid-chromatography-coupled-to-tandem-mass-spectrometry-method-for-the-simultaneous-detection-of-nine-drugs-of-abuse-and-their-metabolites-in-hair-and-nails
#3
Delphine Cappelle, Mireille De Doncker, Celine Gys, Kamelia Krysiak, Steven De Keukeleire, Walid Maho, Cleo L Crunelle, Geert Dom, Adrian Covaci, Alexander L N van Nuijs, Hugo Neels
Hair and nails allow for a stable accumulation of compounds over time and retrospective investigation of past exposure and/or consumption. Owing to their long window of detection (weeks to months), analysis of these matrices can provide information complementary to blood and urine analysis or can be used in standalone when e.g. elimination from the body has already occurred. Drugs of abuse are often used together and, therefore, multi-analyte methods capable of detecting several substances and their metabolites in a single run are of importance...
April 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28165283/parasiticidal-effect-of-synthetic-bovine-lactoferrin-peptides-on-the-enteric-parasite-giardia-intestinalis
#4
Hugo Aguilar-Diaz, Adrian Canizalez-Roman, Tomas Nepomuceno-Mejia, Francisco Gallardo-Vera, Yolanda Hornelas-Orozco, Kamran Nazmi, Jan G M Bolscher, Julio Cesar Carrero, Claudia Leon-Sicairos, Nidia Leon-Sicairos
Giardia intestinalis is the most common infectious protozoan parasite in children. Despite the effectiveness of some drugs, the disease remains a major worldwide problem. Consequently, the search for new treatments is important for disease eradication. Biological molecules with antimicrobial properties represent a promising alternative to combat pathogens. Bovine lactoferrin (bLF) is a key component of the innate host defense system, and its peptides have exhibited strong antimicrobial activity. Based on these properties, we evaluated the parasiticidal activity of these peptides on G...
February 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28146631/tunable-doping-in-hydrogenated-single-layered-molybdenum-disulfide
#5
Debora Pierucci, Hugo Henck, Zeineb Ben Aziza, Carl H Naylor, Adrian Balan, Julien E Rault, Mathieu G Silly, Yannick J Dappe, François Bertran, Patrick Le Fèvre, Fausto Sirotti, A T Charlie Johnson, Abdelkarim Ouerghi
Structural defects in the molybdenum disulfide (MoS2) monolayer are widely known for strongly altering its properties. Therefore, a deep understanding of these structural defects and how they affect MoS2 electronic properties is of fundamental importance. Here, we report on the incorporation of atomic hydrogen in monolayered MoS2 to tune its structural defects. We demonstrate that the electronic properties of single layer MoS2 can be tuned from the intrinsic electron (n) to hole (p) doping via controlled exposure to atomic hydrogen at room temperature...
February 6, 2017: ACS Nano
https://www.readbyqxmd.com/read/27881840/a-combined-linkage-and-association-strategy-identifies-a-variant-near-the-gstp1-gene-associated-with-bmi-in-the-mexican-population
#6
Hugo Villamil-Ramírez, Paola León-Mimila, Luis R Macias-Kauffer, Adrián Canizalez-Román, Marisela Villalobos-Comparán, Nidia León-Sicairos, Joel Vega-Badillo, Fausto Sánchez-Muñoz, Blanca López-Contreras, Sofía Morán-Ramos, Teresa Villarreal-Molina, Luis C Zurita, Francisco Campos-Pérez, Adriana Huertas-Vazquez, Rafael Bojalil, Sandra Romero-Hidalgo, Carlos A Aguilar-Salinas, Samuel Canizales-Quinteros
Obesity is a major public health concern in Mexico and worldwide. Although the estimated heritability is high, common variants identified by genome-wide association studies explain only a small proportion of this heritability. A combination of linkage and association strategies could be a more robust and powerful approach to identify other obesity-susceptibility variants. We thus sought to identify novel genetic variants associated with obesity-related traits in the Mexican population by combining these methods...
November 24, 2016: Journal of Human Genetics
https://www.readbyqxmd.com/read/27881084/assessing-characteristics-of-rna-amplification-methods-for-single-cell-rna-sequencing
#7
Hannah R Dueck, Rizi Ai, Adrian Camarena, Bo Ding, Reymundo Dominguez, Oleg V Evgrafov, Jian-Bing Fan, Stephen A Fisher, Jennifer S Herstein, Tae Kyung Kim, Jae Mun Hugo Kim, Ming-Yi Lin, Rui Liu, William J Mack, Sean McGroty, Joseph D Nguyen, Neeraj Salathia, Jamie Shallcross, Tade Souaiaia, Jennifer M Spaethling, Christopher P Walker, Jinhui Wang, Kai Wang, Wei Wang, Andre Wildberg, Lina Zheng, Robert H Chow, James Eberwine, James A Knowles, Kun Zhang, Junhyong Kim
BACKGROUND: Recently, measurement of RNA at single cell resolution has yielded surprising insights. Methods for single-cell RNA sequencing (scRNA-seq) have received considerable attention, but the broad reliability of single cell methods and the factors governing their performance are still poorly known. RESULTS: Here, we conducted a large-scale control experiment to assess the transfer function of three scRNA-seq methods and factors modulating the function. All three methods detected greater than 70% of the expected number of genes and had a 50% probability of detecting genes with abundance greater than 2 to 4 molecules...
November 24, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27797711/influence-of-body-mass-index-on-hair-ethyl-glucuronide-concentrations
#8
Cleo L Crunelle, Hugo Neels, Kristof Maudens, Mireille De Doncker, Delphine Cappelle, Frieda Matthys, Geert Dom, Erik Fransen, Peter Michielsen, Steven De Keukeleire, Adrian Covaci, Michel Yegles
AIM: Analysis of ethyl glucuronide (EtG) concentrations in hair is increasingly used to estimate the consumption of alcohol of the prior months. Linear correlations between the amount of alcohol consumed and the concentration of EtG in hair have been reported, and several variables that may influence this correlation have been investigated: e.g. cosmetic hair treatments, gender influences or hair color. Here, we investigate the influence of body mass index (BMI) on this correlation. METHODS: A post hoc analysis on the influence of BMI on the relation between amounts of alcohol consumed and the measured EtG concentrations in hair in 199 participants...
January 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/27779613/child-turcotte-pugh-class-is-best-at-stratifying-risk-in-variceal-hemorrhage-analysis-of-a-us-multicenter-prospective-study
#9
Brett E Fortune, Guadalupe Garcia-Tsao, Maria Ciarleglio, Yanhong Deng, Michael B Fallon, Samuel Sigal, Naga P Chalasani, Joseph K Lim, Adrian Reuben, Hugo E Vargas, Gary Abrams, Michele D Lewis, Tarek Hassanein, James F Trotter, Arun J Sanyal, Kimberly L Beavers, Daniel Ganger, Paul J Thuluvath, Norman D Grace, Roberto J Groszmann
GOALS/BACKGROUND: Data on acute variceal hemorrhage (AVH) in the United States is limited and the best method to stratify risk is not clear. Taking advantage of a prospective US cohort study, we aimed to (1) describe clinical outcomes of AVH and their predictors; (2) compare predictors of 6-week mortality. STUDY: Prospective 15-center US cohort of patients with cirrhosis presenting with endoscopically proven AVH, all of whom received antibiotics, vapreotide (a somatostain analog) infusion and endoscopic band ligation...
October 24, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27766855/does-biotransformation-of-aryl-phosphate-flame-retardants-in-blood-cast-a-new-perspective-on-their-debated-biomarkers
#10
Nele Van den Eede, Ana Ballesteros-Gómez, Hugo Neels, Adrian Covaci
Aryl phosphate flame retardants (aryl-PFRs), such as triphenyl phosphate (TPHP) and 2-ethylhexyl diphenyl phosphate (EHDPHP), are emerging contaminants that can exhibit toxic properties, including severe aquatic toxicity and endocrine disruptive effects. Monitoring exposure to aryl-PFRs through specific biomarkers is necessary to assess the health risk associated with chronic exposure. Hydrolytic serum enzymes could play an important role in the formation of the hydrolysis product diphenyl phosphate (DPHP), the seemingly most abundant in vivo biomarker of TPHP in urine...
November 15, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27725679/imaging-biomarker-roadmap-for-cancer-studies
#11
James P B O'Connor, Eric O Aboagye, Judith E Adams, Hugo J W L Aerts, Sally F Barrington, Ambros J Beer, Ronald Boellaard, Sarah E Bohndiek, Michael Brady, Gina Brown, David L Buckley, Thomas L Chenevert, Laurence P Clarke, Sandra Collette, Gary J Cook, Nandita M deSouza, John C Dickson, Caroline Dive, Jeffrey L Evelhoch, Corinne Faivre-Finn, Ferdia A Gallagher, Fiona J Gilbert, Robert J Gillies, Vicky Goh, John R Griffiths, Ashley M Groves, Steve Halligan, Adrian L Harris, David J Hawkes, Otto S Hoekstra, Erich P Huang, Brian F Hutton, Edward F Jackson, Gordon C Jayson, Andrew Jones, Dow-Mu Koh, Denis Lacombe, Philippe Lambin, Nathalie Lassau, Martin O Leach, Ting-Yim Lee, Edward L Leen, Jason S Lewis, Yan Liu, Mark F Lythgoe, Prakash Manoharan, Ross J Maxwell, Kenneth A Miles, Bruno Morgan, Steve Morris, Tony Ng, Anwar R Padhani, Geoff J M Parker, Mike Partridge, Arvind P Pathak, Andrew C Peet, Shonit Punwani, Andrew R Reynolds, Simon P Robinson, Lalitha K Shankar, Ricky A Sharma, Dmitry Soloviev, Sigrid Stroobants, Daniel C Sullivan, Stuart A Taylor, Paul S Tofts, Gillian M Tozer, Marcel van Herk, Simon Walker-Samuel, James Wason, Kaye J Williams, Paul Workman, Thomas E Yankeelov, Kevin M Brindle, Lisa M McShane, Alan Jackson, John C Waterton
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and drug development. New IBs need to be established either as useful tools for testing research hypotheses in clinical trials and research studies, or as clinical decision-making tools for use in healthcare, by crossing 'translational gaps' through validation and qualification...
March 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/27588258/a-randomized-controlled-study-of-peginterferon-lambda-1a-ribavirin%C3%A2-%C3%A2-%C3%A2-daclatasvir-for-hepatitis-c-virus-genotype-2-or-3
#12
Graham R Foster, Kazuaki Chayama, Wan-Long Chuang, Hugo Fainboim, Martti Farkkila, Adrian Gadano, Giovanni B Gaeta, Christophe Hézode, Yukiko Inada, Jeong Heo, Hiromitsu Kumada, Sheng-Nan Lu, Patrick Marcellin, Christophe Moreno, Stuart K Roberts, Simone I Strasser, Alexander J Thompson, Joji Toyota, Seung Woon Paik, John M Vierling, Anna L Zignego, David Cohen, Fiona McPhee, Megan Wind-Rotolo, Subasree Srinivasan, Matthew Hruska, Heather Myler, Simon D Portsmouth
BACKGROUND AND PURPOSE: Peginterferon Lambda was being developed as an alternative to alfa interferon for the treatment of chronic hepatitis C virus (HCV) infection. We compared peginterferon Lambda-1a plus ribavirin (Lambda/RBV) and Lambda/RBV plus daclatasvir (DCV; pangenotypic NS5A inhibitor) with peginterferon alfa-2a plus RBV (alfa/RBV) in treatment-naive patients with HCV genotype 2 or 3 infection. METHODS: In this multicenter, double-blind, phase 3 randomized controlled trial, patients were assigned 2:2:1 to receive 24 weeks of Lambda/RBV, 12 weeks of Lambda/RBV + DCV, or 24 weeks of alfa/RBV...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27546524/efficacy-of-erbium-yag-laser-treatment-compared-to-topical-estriol-treatment-for-symptoms-of-genitourinary-syndrome-of-menopause
#13
Adrian Gaspar, Hugo Brandi, Valentin Gomez, Daniel Luque
OBJECTIVES: The objective of this prospective comparative cohort study was to establish the effectiveness and safety of Erbium:YAG (Er:YAG) laser treatment for genitourinary syndrome of menopause and to compare it with an established topical estriol treatment. METHODS: Fifty patients with genitourinary syndrome of menopause were divided into two groups. The estriol group received a treatment of 0.5 mg estriol ovules for 8 weeks and the laser group was first treated for 2 weeks with 0...
August 22, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27404950/a-nanoarchitecture-based-on-silver-and-copper-oxide-with-an-exceptional-response-in-the-chlorine-promoted-epoxidation-of-ethylene
#14
Adrian Ramirez, Jose L Hueso, Hugo Suarez, Reyes Mallada, Alfonso Ibarra, Silvia Irusta, Jesus Santamaria
The selective oxidation of ethylene to ethylene epoxide is highly challenging as a result of competing reaction pathways leading to the deep oxidation of both ethylene and ethylene oxide. Herein we present a novel catalyst based on silver and copper oxide with an excellent response in the selective oxidation pathway towards ethylene epoxide. The catalyst is composed of different silver nanostructures dispersed on a tubular copper oxide matrix. This type of hybrid nanoarchitecture seems to facilitate the accommodation of chlorine promoters, leading to high yields at low reaction temperatures...
September 5, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27350238/comprehensive-study-of-human-external-exposure-to-organophosphate-flame-retardants-via-air-dust-and-hand-wipes-the-importance-of-sampling-and-assessment-strategy
#15
Fuchao Xu, Georgios Giovanoulis, Sofie van Waes, Juan Antonio Padilla-Sanchez, Eleni Papadopoulou, Jorgen Magnér, Line Småstuen Haug, Hugo Neels, Adrian Covaci
We compared the human exposure to organophosphate flame retardants (PFRs) via inhalation, dust ingestion, and dermal absorption using different sampling and assessment strategies. Air (indoor stationary air and personal ambient air), dust (floor dust and surface dust), and hand wipes were sampled from 61 participants and their houses. We found that stationary air contains higher levels of ΣPFRs (median = 163 ng/m(3), IQR = 161 ng/m(3)) than personal air (median = 44 ng/m(3), IQR = 55 ng/m(3)), suggesting that the stationary air sample could generate a larger bias for inhalation exposure assessment...
July 19, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27281693/band-alignment-and-minigaps-in-monolayer-mos2-graphene-van-der-waals-heterostructures
#16
Debora Pierucci, Hugo Henck, Jose Avila, Adrian Balan, Carl H Naylor, Gilles Patriarche, Yannick J Dappe, Mathieu G Silly, Fausto Sirotti, A T Charlie Johnson, Maria C Asensio, Abdelkarim Ouerghi
Two-dimensional layered MoS2 shows great potential for nanoelectronic and optoelectronic devices due to its high photosensitivity, which is the result of its indirect to direct band gap transition when the bulk dimension is reduced to a single monolayer. Here, we present an exhaustive study of the band alignment and relativistic properties of a van der Waals heterostructure formed between single layers of MoS2 and graphene. A sharp, high-quality MoS2-graphene interface was obtained and characterized by micro-Raman spectroscopy, high-resolution X-ray photoemission spectroscopy (HRXPS), and scanning high-resolution transmission electron microscopy (STEM/HRTEM)...
July 13, 2016: Nano Letters
https://www.readbyqxmd.com/read/27246929/large-area-molybdenum-disulphide-epitaxial-graphene-vertical-van-der-waals-heterostructures
#17
Debora Pierucci, Hugo Henck, Carl H Naylor, Haikel Sediri, Emmanuel Lhuillier, Adrian Balan, Julien E Rault, Yannick J Dappe, François Bertran, Patrick Le Fèvre, A T Charlie Johnson, Abdelkarim Ouerghi
Two-dimensional layered transition metal dichalcogenides (TMDCs) show great potential for optoelectronic devices due to their electronic and optical properties. A metal-semiconductor interface, as epitaxial graphene - molybdenum disulfide (MoS2), is of great interest from the standpoint of fundamental science, as it constitutes an outstanding platform to investigate the interlayer interaction in van der Waals heterostructures. Here, we study large area MoS2-graphene-heterostructures formed by direct transfer of chemical-vapor deposited MoS2 layer onto epitaxial graphene/SiC...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26889657/biotransformation-of-three-phosphate-flame-retardants-and-plasticizers-in-primary-human-hepatocytes-untargeted-metabolite-screening-and-quantitative-assessment
#18
Nele Van den Eede, Ingrid de Meester, Walid Maho, Hugo Neels, Adrian Covaci
Tris(2-butoxyethyl) phosphate (TBOEP), triphenyl phosphate (TPHP) and tris(1-chloro-2-propyl) phosphate (TCIPP) are current high-volume organophosphate flame retardants/plasticizers (PFRs) and are abundant in the indoor environment. While recent in vitro research has indicated potential toxic effects in the endocrine system, biotransformation of these compounds is still underexplored. In this study, we aimed to characterize the metabolite formation for three PFRs in primary human hepatocytes, an in vitro system that mimics in vivo liver metabolism more closely than hepatic subcellular fractions or cell lines...
November 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/26851349/hair-ethyl-glucuronide-and-serum-carbohydrate-deficient-transferrin-for-the-assessment-of-relapse-in-alcohol-dependent-patients
#19
Cleo L Crunelle, Jef Verbeek, Geert Dom, Adrian Covaci, Michel Yegles, Peter Michielsen, Mireille De Doncker, Frederik Nevens, Delphine Cappelle, Alexander L N van Nuijs, Hugo Neels
OBJECTIVES: Ethyl glucuronide in hair (hEtG) and serum carbohydrate deficient transferrin (%CDT) are valuable markers for alcohol abuse, but their diagnostic accuracy to monitor abstinence and relapse is unclear. Here, we investigate to what extent repeated measurements of hEtG and %CDT can be used to monitor relapse in alcohol-dependent patients during abstinence treatment. DESIGN AND METHODS: HEtG and %CDT were measured in individuals starting treatment for alcohol dependence both at treatment entry and 3months later...
May 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/26804900/spatial-and-temporal-trends-in-alcohol-consumption-in-belgian-cities-a-wastewater-based-approach
#20
Tim Boogaerts, Adrian Covaci, Juliet Kinyua, Hugo Neels, Alexander L N van Nuijs
BACKGROUND: In recent years, scientific evidence has emerged that wastewater-based epidemiology can deliver complementary information concerning the use of different substances of abuse. In this study, the potential of wastewater-based epidemiology in monitoring spatial and temporal trends in alcohol consumption in different populations in Belgium has been examined. METHODS: Concentrations of ethyl sulphate, a minor Phase-II metabolite of ethanol, in 163 influent wastewater samples from eight wastewater treatment plants in Belgium in the period 2013-2015 were measured with liquid chromatography coupled to tandem mass spectrometry and used to estimate alcohol consumption...
March 1, 2016: Drug and Alcohol Dependence
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