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Behcet's disease

Siyar Erdogmus, Zeynep Kendi Celebi, Serkan Akturk, Gizem Kumru, Neval Duman, Kenan Ates, Sehsuvar Erturk, Gokhan Nergizoglu, Sim Kutlay, Sule Sengul, Kenan Keven
OBJECTIVE: In epidemiological studies of amyloid A (AA) amyloidosis from Turkey, the most frequently cause was familial Mediterranean fever (FMF) and it occurs generally in young age population. However, there are no sufficient data regarding aetiology, clinical presentation and prognosis of renal AA amyloidosis in advanced age patients. In this study, we aimed to investigate demographic, clinical presentation, aetiology and outcomes of adults aged 60 years or older patients with biopsy-proven renal AA amyloidosis...
May 18, 2018: Amyloid: the International Journal of Experimental and Clinical Investigation
Serkan Burç Deşer, Savas Yuruker, Mustafa Kemal Demirag
Compression of the celiac artery by the median arcuate ligament (MAL) and neurofibrous tissue is called MAL syndrome or Dunbar's syndrome. Postprandial abdominal pain, weight loss are the main symptoms. Surgical treatment still remains the gold standard therapy. Here, we present the first case to our knowledge that accompanying Behcet's disease to Median Arcuate Ligament Syndrome.
May 14, 2018: Annals of Vascular Surgery
U Amstutz, D Schaerer, G Andrey, U Wirthmueller, C R Largiadèr
HLA-A*29 and HLA-B*51 are associated with birdshot uveitis and Behçet's disease, respectively, and are used as a diagnostic criterion in patients with suspected disease, requiring their detection in diagnostic laboratories. While commercial tests for individual HLA alleles are available for other disease-associated HLA variants, no similar allele-specific assays are available for HLA-A*29 and -B*51. Here, we report SSP-PCR methods for the detection of HLA-A*29 and -B*51 using a single PCR reaction per allele...
May 15, 2018: HLA
Olga Meltem Akay
Hemostasis is a complex dynamic process involving bleeding and thrombosis as two end-points. Conventional coagulation tests which are measured in plasma examine only isolated portions of the coagulation cascade, thereby giving no information on important interactions essential to the clinical evaluation of hemostatic function. Thromboelastography (TEG), originally described in 1948 has improved over the decades and become a valuable tool of coagulation testing because of the limitations of standard coagulation tests...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
Yoshinori Taniguchi, Shigeru Nojima, Mitsuru Nishiyama, Yoshio Terada
No abstract text is available yet for this article.
May 11, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Weichun Wu, David H Hsi, Haiping Wang, Chao Dong, LiLi Niu, Hao Wang
We report a very rare case of mitral valve dissection and aortic-left ventricular tunnel caused by possible autoimmune vasculitis. We suspected Behcet's disease in this patient. There was no obvious clinical evidence of infective endocarditis. Echocardiography is the diagnostic tool of choice to recognize valvular dysfunction, related pathology, and possible complications. The patient may require immunosuppressive therapy due to the high likelihood of recurrence in the perioperation period.
May 14, 2018: Echocardiography
Doa W Nada, Radwa M El Khouly, Souzan E Gadow, Shymaa A Hablas, Marwa A Aboelhawa, Doaa S Al Ashkar, Amal M El Barbary, Manal S Hussein, Elsayed Rageh, Alaa M Elsalawy, Mohamed H Abo-Zaid, Samah Elshweikh, Amani M El Gharib
OBJECTIVES: To determine the types and to assess the role of auditory evoked potentials and otoacoustic emissions in early detection of hearing abnormalities in Behçet's disease (BD) patients. Their correlations with disease activity were also considered. METHODS: Thirty patients with BD and thirty apparently sex- and age-matched healthy volunteers were included in this study. Auditory evaluation included pure tone audiometry (PTA), otoacoustic emissions (TEOAEs, DPOAE), auditory brainstem response test (ABR) and cortical auditory evoked potentials (tone and speech CAEPs) for all patients and control...
May 10, 2018: Clinical and Experimental Rheumatology
Monica Rodríguez-Carballeira, Roser Solans, Jose Ramon Larrañaga, Francisco Javier García-Hernández, Raquel Rios-Fernández, Javier Nieto, Xavier Solanich, Ferran Martínez-Valle, Eva Fonseca, Francisco Jose Muñoz, Guadalupe Fraile, Begoña de Escalante, Rafael Boldova, Robert Hurtado, Gerard Espinosa
OBJECTIVES: To describe the characteristics of patients with Behçet's disease (BD) who presented with venous thrombosis. In addition, we identified the factors associated with this venous involvement and those related with recurrent venous thrombosis. METHODS: Up to January 2015, 544 BD patients from 20 Spanish hospitals had been included in the REGEB (REGistro de la Enfermedad de Behçet as Spanish nomenclature). We selected those patients who presented venous thrombosis...
May 3, 2018: Clinical and Experimental Rheumatology
Jihye Park, Jae Hee Cheon, Yehyun Park, Soo Jung Park, Tae Il Kim, Won Ho Kim
No abstract text is available yet for this article.
April 2018: Intestinal Research
Yu-Hao Lin, Tzu-Yang Tai, Cheng-Yun Pu, De-Kuang Hwang, Yu-Mei Chung, Yiing-Jeng Chou
PURPOSE: To study the incidence and epidemiology of Behcet's disease in Taiwan. METHODS: This retrospective cohort study was conducted using the nationwide reimbursement database in Taiwan. One million registered beneficiaries of the Taiwan National Health Insurance system in 2000 were randomly selected. All medical claims of these persons were collected. The definition of having Behcet's disease was based on diagnostic codes. Persons who had incomplete registry data or diagnoses prior to 2001 were excluded...
May 4, 2018: Ophthalmic Epidemiology
Mohammed Hamouda, Hanaa Dakour Aridi, Rachel Elizabeth Lee, Jasninder Singh Dhaliwal, Mahmoud B Malas
Only a few cases of infrapopliteal aneurysms are reported in the literature. These are commonly associated with trauma, infection, and iatrogenic injuries and mostly present as pseudoaneurysms. We report the case of a 44-year-old man with Behçet disease and an 8-cm tibioperoneal trunk aneurysm and discuss the management options of these aneurysms.
March 2018: Journal of Vascular Surgery Cases and Innovative Techniques
Seyedeh Maryam Hosseini, Nasser Shoeibi, Raheleh Ebrahimi, Mehdi Ghasemi
Purpose: To describe the demographic and clinical patterns of patients with uveitis referred to a tertiary center in northeastern Iran. Methods: This cross-sectional retrospective study included 235 patients with uveitis who had been referred to the uveitis clinic of Khatam-Al-Anbia eye hospital, affiliated to Mashhad University of Medical Sciences, from February 2013 to March 2014. Data regarding patient age, sex, anatomical location of the disease, and etiologic and clinical features were analyzed...
April 2018: Journal of Ophthalmic & Vision Research
Shahriar Alipour, Mohammad Nouri, Alireza Khbbazi, Nasser Samadi, Zohreh Babaloo, Somayeh Abolhasani, Jafar Farhadi, Neda Roshanravan, Golamreza Jadideslam, Ebrahim Sakhimia
Interleukin-10 (IL-10), produced generally by monocyte, T helper type 2 (Th2), and regulatory T cells (Treg), plays a central role in controlling inflammatory responses and regulating the immune response of the IL-10 mRNA expression. It is significantly down-regulated in many autoimmune diseases such as Behçet's disease; this is mostly associated with more aggressive complications. Nevertheless, the essential molecular process for its low expression has not been completely realized. The aim of this project was attempted to estimate the gene expression, promoter methylation, and protein levels to IL-10's down-regulated expression...
May 2, 2018: Journal of Cellular Biochemistry
Ying-Shiung Kuo, Julia Yu-Fong Chang, Yi-Ping Wang, Yang-Che Wu, Yu-Hsueh Wu, Andy Sun
BACKGROUND/PURPOSE: Behcet's disease (BD) patients may have one or more hematinic deficiencies. This study evaluated whether there were significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia in BD patients. METHODS: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations in 63 BD patients were measured and compared with the corresponding levels in 126 age- and sex-matched healthy control subjects...
April 28, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Ahmed M Abu El-Asrar, Nele Berghmans, Saleh A Al-Obeidan, Priscilla W Gikandi, Ghislain Opdenakker, Jo Van Damme, Sofie Struyf
Purpose: To determine the levels of the neutrophil chemoattractants CXCL1, CXCL2, CXCL5, CXCL6, and CXCL8, the T helper 1 chemoattractants CXCL9, CXCL10 and CXCL11, the lymphoid chemokines CXCL12 and CXCL13 and the soluble form of the transmembrane chemokines CXCL16 and CX3CL1, in aqueous humor samples from patients with specific uveitic entities. Methods: Aqueous humor samples from patients with active uveitis associated with Behçet's disease (n = 13), sarcoidosis (n = 8), HLA-B27-related inflammation (n = 12), Vogt-Koyanagi-Harada (VKH) disease (n = 12), and healthy controls (n = 9) were assayed with the use of a multiplex assay...
May 1, 2018: Investigative Ophthalmology & Visual Science
Cem Cankaya, Tongabay Cumurcu, Abuzer Gunduz, Ilknur Fırat
PURPOSE: To evaluate alterations in the corneal endothelial layer in Behçet's disease (BD) with inactive ocular involvement using specular microscopy. MATERIALS AND METHODS: Thirty-three eyes of 33 BD patients who had at least one anterior segment involvement and no active inflammation in the last 3 months were included in the study (group 1). Twenty-seven of the thirty-three BD patients had an anterior uveitis attack and six of them had a panuveitis (both anterior and posterior involvement) attack...
May 1, 2018: Current Eye Research
C Brenière, C Blanc, H Devilliers, M Samson, B Delpont, P Bielefeld, J-F Besancenot, M Giroud, Y Béjot
Behçet's disease is a rare multisystemic vasculitis with an etiology that is still unknown. Neurological manifestations may be seen in approximately 5-15% of patients, and both parenchymal and extraparenchymal neurological involvement has been described. When cerebral venous thrombosis (CVT) is the main extraparenchymal manifestation of Behçet's disease, the condition is then dubbed "angio-Behçet's syndrome". However, arterial involvement is extremely rare, with only one reported case of vasculo-neuro-Behçet's disease, characterized by both venous and intracranial arterial involvement - until now...
April 25, 2018: Revue Neurologique
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Medicine (Baltimore)
Yue He, Chaokui Wang, Guannan Su, Bolin Deng, Zi Ye, Yang Huang, Gangxiang Yuan, Kijlstra Aize, Hong Li, Peizeng Yang
PURPOSE: A20 is a ubiquitously expressed and inducible cytosolic protein, which plays an important role in the negative regulation of inflammation and immunity. In this study, we investigated the role of A20 in Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) disease. METHODS: The levels of A20 in peripheral blood mononuclear cells (PBMCs) and dendritic cells (DCs) were detected in BD patients with active and inactive uveitis, VKH patients with active and inactive uveitis, and normal subjects, respectively, by real-time PCR...
April 26, 2018: British Journal of Ophthalmology
Ammr Alghamdi, Bahram Bodaghi, Chloé Comarmond, Anne Claire Desbois, Fanny Domont, Bertrand Wechsler, Raphael Depaz, Phuc Le Hoang, Patrice Cacoub, Valérie Touitou, David Saadoun
BACKGROUND: The neuro-ophthalmological manifestations of Behcet's disease (BD) are rare, and data regarding their characteristics and outcome are lacking. OBJECTIVE: To report prevalence, main characteristics and outcome of neuro-ophthalmological manifestations in BD. PATIENTS AND METHODS: This is a retrospective monocentric study of 217 patients diagnosed with neuro-Behçet's disease (NBD), of whom 29 (13.3%) patients presented with neuro-ophthalmological manifestations (55% of men and mean±SD age of 26±8 years)...
April 26, 2018: British Journal of Ophthalmology
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