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https://www.readbyqxmd.com/read/29126099/clinical-utility-of-select-neuropsychological-assessment-battery-tests-in-predicting-functional-abilities-in-dementia
#1
Lee Ashendorf, Michael L Alosco, Hanaan Bing-Canar, Kimberly R Chapman, Brett Martin, Christine E Chaisson, Diane Dixon, Eric G Steinberg, Yorghos Tripodis, Neil W Kowall, Robert A Stern
Objective: Neuropsychological test performance can provide insight into functional abilities in patients with dementia, particularly in the absence of an informant. The relationship between neuropsychological measures and instrumental activities of daily living (IADLs) is unclear due to hetereogeneity in cognitive domains assessed and neuropsychological tests administered. Practical and ecologically valid performance-based measures of IADLs are also limited. The Neuropsychological Assessment Battery (NAB) is uniquely positioned to provide a dual-purpose assessment of cognitive and IADL function, as it includes Daily Living tests that simulate real-world functional tasks...
November 8, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29125488/comparison-between-fcsrt-and-lassi-l-to-detect-early-stage-alzheimer-s-disease
#2
Jordi A Matias-Guiu, María Nieves Cabrera-Martín, Rosie E Curiel, María Valles-Salgado, Teresa Rognoni, Teresa Moreno-Ramos, José Luis Carreras, David A Loewenstein, Jorge Matías-Guiu
BACKGROUND: The Free and Cued Selective Reminding Test (FCSRT) is the most accurate test for the diagnosis of prodromal Alzheimer's disease (AD). Recently, a novel cognitive test, the Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L), has been developed in order to provide an early diagnosis. OBJECTIVE: To compare the diagnostic accuracy of the FCSRT and the LASSI-L for the diagnosis of AD in its preclinical and prodromal stages using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) as a reference...
November 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29119954/-the-role-of-dosed-walking-in-the-combination-with-elements-of-cognitive-training-in-the-comprehensive-treatment-of-the-patients-presenting-with-alzheimer-s-disease
#3
N A Zimushkina, P V Kosareva, V G Cherkasova
AIM: The objective of the present study was to evaluate the effectiveness of dosed physical exercises for the combined treatment of the patients presenting with mild to moderate dementia associated with Alzheimer's disease (AD). MATERIAL AND METHODS: The comprehensive examination involved 41 patients (32 women and 9 men) with the confirmed diagnosis of 'probable' AD with stages 1 and 2 of dementia and 17 healthy volunteers comprising the group of comparison. In all the patients, the neurological examination was supplemented by neuropsychological testing...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29114732/amyloid-%C3%AE-deposition-and-suspected-non-alzheimer-pathophysiology-and-cognitive-decline-patterns-for-12-years-in-oldest-old-participants-without-dementia
#4
Yujing Zhao, Dana L Tudorascu, Oscar L Lopez, Ann D Cohen, Chester A Mathis, Howard J Aizenstein, Julie C Price, Lewis H Kuller, M Ilyas Kamboh, Steven T DeKosky, William E Klunk, Beth E Snitz
Importance: The prevalence of pathologic conditions of the brain associated with Alzheimer disease increases strongly with age. Little is known about the distribution and clinical significance of preclinical biomarker staging in the oldest old, when most individuals without dementia are likely to have positive biomarkers. Objective: To compare the patterns of long-term cognitive decline in multiple domains by preclinical biomarker status in the oldest old without dementia...
November 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29111487/cortical-%C3%AE-amyloid-burden-gray-matter-and-memory-in-adults-at-varying-apoe-%C3%AE%C2%B54-risk-for-alzheimer-s-disease
#5
Adam P Mecca, Nicole M Barcelos, Shuo Wang, Anna Brück, Nabeel Nabulsi, Beata Planeta-Wilson, Jennifer Nadelmann, Amanda L Benincasa, Jim Ropchan, Yiyun Huang, Joel Gelernter, Peter H Van Ness, Richard E Carson, Christopher H van Dyck
Models of preclinical Alzheimer's disease (AD) propose that cerebral amyloidosis leads to neurodegeneration and subsequent cognitive decline. This study investigated whether APOE genotype is related to β-amyloid (Aβ) burden in brain regions preferentially affected by AD and whether Aβ burden is associated with gray-matter (GM) fraction (as a marker of neurodegeneration) and episodic memory performance in cognitively normal middle-aged individuals at varying genetic risk for AD. Three groups of cognitively normal participants aged 50-65 years with a first-degree family history of AD (APOE genotype ε4ε4 [n = 15], ε3ε4 [n = 15], and ε3ε3 [n = 15]) underwent [(11)C]PiB positron emission tomography scans to quantify cortical Aβ, brain magnetic resonance imaging, and neuropsychological testing...
October 6, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29111486/gray-matter-network-measures-are-associated-with-cognitive-decline-in-mild-cognitive-impairment
#6
Ellen Dicks, Betty M Tijms, Mara Ten Kate, Alida A Gouw, Marije R Benedictus, Charlotte E Teunissen, Frederik Barkhof, Philip Scheltens, Wiesje M van der Flier
Gray matter networks are disrupted in Alzheimer's disease and related to cognitive impairment. However, it is still unclear whether these disruptions are associated with cognitive decline over time. Here, we studied this question in a large sample of patients with mild cognitive impairment with extensive longitudinal neuropsychological assessments. Gray matter networks were extracted from baseline structural magnetic resonance imaging, and we tested associations of network measures and cognitive decline in Mini-Mental State Examination and 5 cognitive domains (i...
October 6, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29111133/in-vivo-brain-plaque-and-tangle-burden-mediates-the-association-between-diastolic-blood-pressure-and-cognitive-functioning-in-nondemented-adults
#7
Florence F Roussotte, Prabha Siddarth, David A Merrill, Katherine L Narr, Linda M Ercoli, Jacqueline Martinez, Natacha D Emerson, Jorge R Barrio, Gary W Small
OBJECTIVE: Growing evidence supports an association between increased blood pressure and: (a) poor cognitive performance in older adults, and (b) various biomarkers of increased Alzheimer's disease (AD) neuropathology. The objective of this study was to determine whether systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly associated with cognitive functioning in non-demented adults, and to examine in vivo AD pathology as a possible mediator of this association...
September 15, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29111023/can-fibrinolytic-system-components-explain-cognitive-impairment-in-multiple-sclerosis
#8
María Yaiza Pérez-Martín, Montserrat González-Platas, Alejandro Jiménez-Sosa, Julio Plata-Bello, Francisco Javier Carrillo-Padilla, Andrés Franco-Maside, Pablo Eguia-Del Río
BACKGROUND: The fibrinolytic system is capable of modulating inflammatory and degenerative events within the central nervous system. Specifically, the plasminogen activator inhibitor-1 (PAI-1) has been associated with different pathological conditions in multiple sclerosis (MS) and its role in cognitive functioning is also known. OBJECTIVES AND METHODS: To study the association between plasma levels and the polymorphic variants of the PAI-1 gene and cognitive performance in MS...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29110613/a-biomarker-combining-imaging-and-neuropsychological-assessment-for-tracking-early-alzheimer-s-disease-in-clinical-trials
#9
Nishant Verma, S Natasha Beretvas, Belen Pascual, Joseph C Masdeu, Mia K Markey, The Alzheimer S Disease Neuroimaging Initiative
BACKGROUND: Combining optimized cognitive (Alzheimer's Disease Assessment Scale-Cognitive subscale, ADAS-Cog) and atrophy markers of Alzheimer's disease for tracking progression in clinical trials may provide greater sensitivity than currently used methods, which have yielded negative results in multiple recent trials. Furthermore, it is critical to clarify the relationship among the subcomponents yielded by cognitive and imaging testing, to address the symptomatic and anatomical variability of Alzheimer's disease...
November 6, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29107184/anxiety-like-behavior-as-an-early-endophenotype-in-the-tgf344-ad-rat-model-of-alzheimer-s-disease
#10
Nathan S Pentkowski, Laura E Berkowitz, Shannon M Thompson, Emma N Drake, Carlos R Olguin, Benjamin J Clark
Alzheimer's disease (AD) is characterized by progressive cognitive decline and the presence of aggregates of amyloid beta (plaques) and hyperphosphorylated tau (tangles). Early diagnosis through neuropsychological testing is difficult due to comorbidity of symptoms between AD and other types of dementia. As a result, there is a need to identify the range of behavioral phenotypes expressed in AD. In the present study, we utilized a transgenic rat (TgF344-AD) model that bears the mutated amyloid precursor protein as well as presenilin-1 genes, resulting in progressive plaque and tangle pathogenesis throughout the cortex...
October 5, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29103404/the-cerad-neuropsychological-assessment-battery-is-sensitive-to-alcohol-related-cognitive-deficiencies-in-elderly-patients-a-retrospective-matched-case-control-study
#11
Liane Kaufmann, Stefan Huber, Daniel Mayer, Korbinian Moeller, Josef Marksteiner
OBJECTIVES: Adverse effects of heavy drinking on cognition have frequently been reported. In the present study, we systematically examined for the first time whether clinical neuropsychological assessments may be sensitive to alcohol abuse in elderly patients with suspected minor neurocognitive disorder. METHODS: A total of 144 elderly with and without alcohol abuse (each group n=72; mean age 66.7 years) were selected from a patient pool of n=738 by applying propensity score matching (a statistical method allowing to match participants in experimental and control group by balancing various covariates to reduce selection bias)...
November 6, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29097166/24-month-intervention-with-a-specific-multinutrient-in-people-with-prodromal-alzheimer-s-disease-lipididiet-a-randomised-double-blind-controlled-trial
#12
Hilkka Soininen, Alina Solomon, Pieter Jelle Visser, Suzanne B Hendrix, Kaj Blennow, Miia Kivipelto, Tobias Hartmann
BACKGROUND: Nutrition is an important modifiable risk factor in Alzheimer's disease. Previous trials of the multinutrient Fortasyn Connect showed benefits in mild Alzheimer's disease dementia. LipiDiDiet investigated the effects of Fortasyn Connect on cognition and related measures in prodromal Alzheimer's disease. Here, we report the 24-month results of the trial. METHODS: LipiDiDiet was a 24-month randomised, controlled, double-blind, parallel-group, multicentre trial (11 sites in Finland, Germany, the Netherlands, and Sweden), with optional 12-month double-blind extensions...
October 30, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/29096697/race-modifies-the-relationship-between-cognition-and-alzheimer-s-disease-cerebrospinal-fluid-biomarkers
#13
Jennifer C Howell, Kelly D Watts, Monica W Parker, Junjie Wu, Alexander Kollhoff, Thomas S Wingo, Cornelya D Dorbin, Deqiang Qiu, William T Hu
BACKGROUND: African Americans have been reported to have a higher prevalence of Alzheimer's disease (AD) than Caucasians, but etiology-specific AD biomarkers have not been systematically analyzed in older African Americans. Coexisting cerebrovascular disease may also contribute to this increased prevalence. We hypothesized that cerebrospinal fluid (CSF) biomarkers of amyloid, neurodegeneration, and endothelial dysfunction would differ between older African Americans and Caucasians with normal cognition and cognitive impairment associated with AD...
November 2, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29082658/cognitive-impairment-in-progressive-supranuclear-palsy-is-associated-with-tau-burden
#14
Shunsuke Koga, Adam Parks, Koji Kasanuki, Monica Sanchez-Contreras, Matthew C Baker, Keith A Josephs, J Eric Ahlskog, Ryan J Uitti, Neill Graff-Radford, Jay A van Gerpen, Zbigniew K Wszolek, Rosa Rademakers, Dennis W Dickson
BACKGROUND: Cognitive impairment is one of the core features of progressive supranuclear palsy. This study aimed to clarify the profile of cognitive impairment and its underlying pathology in progressive supranuclear palsy. METHODS: We retrospectively reviewed medical records to evaluate the pattern and severity of cognitive impairment in 121 autopsy-confirmed progressive supranuclear palsy patients. A subset of 37 patients underwent neuropsychological evaluation as part of their clinical workup...
October 30, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29072103/posterior-cortical-atrophy-of-a-suspected-non-alzheimer-type-a-case-report
#15
Mark T Wagner, Dana M Szeles, Blakely Mulder, Mimi Sohn, Aljoeson Walker
OBJECTIVE: A case of Posterior Cortical Atrophy syndrome of a suspected non-Alzheimer disease pathology type is presented to illustrate prospective diagnosis and course. METHOD: A 54-year-old woman with vague memory complaints underwent serial neuropsychological assessment, MRI, PET, and CSF screening; data are reviewed. RESULTS: While early diagnosis was confounded by multiple factors, classic visuospatial symptoms were later demonstrated using routine neuropsychological methods...
October 26, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29067339/the-bdnf-val66met-polymorphism-moderates-the-effect-of-cognitive-reserve-on-36-month-cognitive-change-in-healthy-older-adults
#16
David D Ward, Ross Andel, Nichole L Saunders, Megan E Thow, Shannon Z Klekociuk, Aidan D Bindoff, James C Vickers
INTRODUCTION: Cognitive reserve (CR) and BDNF Val66Met are independently associated with the rate of cognitive decline in preclinical Alzheimer's disease. This study was designed to investigate the interactive effects of these variables on 36-month cognitive change in cognitively intact older adults. METHODS: Data for this investigation were obtained from 445 community-residing participants of the Tasmanian Healthy Brain Project, who underwent genetic screening and annual assessment of neuropsychological, health, and psychosocial function...
September 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29067331/inferior-parietal-transcranial-direct-current-stimulation-with-training-improves-cognition-in-anomic-alzheimer-s-disease-and-frontotemporal-dementia
#17
Carlos Roncero, Heike Kniefel, Erik Service, Alexander Thiel, Stephan Probst, Howard Chertkow
INTRODUCTION: We evaluated whether transcranial direct current stimulation (tDCS) can improve picture-naming abilities in subjects with anomic Alzheimer or frontotemporal dementias. METHODS: Using a double-blind crossover design, 10 participants were trained on picture naming over a series of 10 sessions with either 30 minutes of anodal (2 mA) tDCS stimulation to the left inferior parieto-temporal region (P3) or sham stimulation. We evaluated performance on a trained picture-naming list, an equivalent untrained list, and additional neuropsychological tasks...
June 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29066367/brain-metabolic-correlates-of-csf-tau-protein-in-a-large-cohort-of-alzheimer-s-disease-patients-a-csf-and-fdg-pet-study
#18
Agostino Chiaravalloti, Gaetano Barbagallo, Maria Ricci, Alessandro Martorana, Francesco Ursini, Pasqualina Sannino, Georgios Karalis, Orazio Schillaci
AIMS: physiopathological mechanisms of Alzheimer's disease (AD) are still matter of debate. Especially the role of amyloid β and tau pathology in the development of the disease are still matter of debate. Changes in tau and amyloid β peptide concentration in cerebrospinal fluid (CSF) and hypometabolic patterns at fluorine-18 fluorodeoxyglucose ((18)F-FDG) PET scanning are considered as biomarkers of AD. The present study was aimed to evaluate the relationships between the concentrations of CSF total Tau (t-Tau), phosphorilated Tau (p-Tau) and Aβ1-42 amyloid peptide with (18)F-FDG brain distribution in a group of patients with AD...
October 21, 2017: Brain Research
https://www.readbyqxmd.com/read/29065419/cognitive-aging-in-dogs
#19
Durga Chapagain, Friederike Range, Ludwig Huber, Zsófia Virányi
A decline in the physical or mental health of older dogs can be a challenge for the owners, whose relationship with their dog is compromised by the cognitive and behavioral changes in their dogs. Although dog owners tend to consider many physiological and behavioral changes in old dogs as part of the normal aging process, it is important to differentiate between normal aging and pathologic aging, since behavioral changes may be the first indication of declining health and welfare in old dogs. Most reviews on cognitive aging in dogs have focused on translational approaches to human Alzheimer's disease; from a practical perspective, however, understanding normal cognitive aging in pet dogs and screening cognitively affected dogs are important in their own right...
October 25, 2017: Gerontology
https://www.readbyqxmd.com/read/29064406/diosgenin-rich-yam-extract-enhances-cognitive-function-a-placebo-controlled-randomized-double-blind-crossover-study-of-healthy-adults
#20
Chihiro Tohda, Ximeng Yang, Mie Matsui, Yuna Inada, Emika Kadomoto, Shotaro Nakada, Hidetoshi Watari, Naotoshi Shibahara
Diosgenin, a yam-derived compound, was found to facilitate the repair of axonal atrophy and synaptic degeneration and improve memory dysfunction in a transgenic mouse model of Alzheimer's disease (AD). It was also found to enhance neuronal excitation and memory function even in normal mice. We hypothesized that diosgenin, either isolated or in an extract, may represent a new category of cognitive enhancers with essential activities that morphologically and functionally reinforce neuronal networks. This study aimed to investigate the effects of a diosgenin-rich yam extract on cognitive enhancement in healthy volunteers...
October 24, 2017: Nutrients
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