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https://www.readbyqxmd.com/read/28731452/temporal-order-of-alzheimer-s-disease-related-cognitive-marker-changes-in-blsa-and-wrap-longitudinal-studies
#1
Murat Bilgel, Rebecca L Koscik, Yang An, Jerry L Prince, Susan M Resnick, Sterling C Johnson, Bruno M Jedynak
Investigation of the temporal trajectories of currently used neuropsychological tests is critical to identifying earliest changing measures on the path to dementia due to Alzheimer's disease (AD). We used the Progression Score (PS) method to characterize the temporal trajectories of measures of verbal memory, executive function, attention, processing speed, language, and mental status using data spanning normal cognition, mild cognitive impairment, and AD from 1,661 participants with a total of 7,839 visits (age at last visit 77...
July 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28731439/antihypertensive-treatment-is-associated-with-mri-derived-markers-of-neurodegeneration-and-impaired-cognition-a-propensity-weighted-cohort-study
#2
Jodi D Edwards, Joel Ramirez, Brandy L Callahan, Sheldon W Tobe, Paul Oh, Courtney Berezuk, Krista Lanctôt, Walter Swardfager, Sean Nestor, Alexander Kiss, Stephen Strother, Sandra E Black
BACKGROUND: Hypertension is an important risk factor for Alzheimer's disease (AD) and cerebral small vessel disease. Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are common anti-hypertensive treatments, but have differential effects on cortical amyloid. OBJECTIVE: The objective of this study was to evaluate associations between anti-hypertensive treatment, brain volume, and cognition, using a propensity-weighted analysis to account for confounding by indication...
July 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28731436/impaired-processing-of-serial-order-determines-working-memory-impairments-in-alzheimer-s-disease
#3
Maya De Belder, Patrick Santens, Anne Sieben, Wim Fias
BACKGROUND: Working memory (WM) problems are commonly observed in Alzheimer's disease (AD), but the affected mechanisms leading to impaired WM are still insufficiently understood. The ability to efficiently process serial order in WM has been demonstrated to be fundamental to fluent daily life functioning. The decreased capability to mentally process serial position in WM has been put forward as the underlying explanation for generally compromised WM performance. OBJECTIVE: Determine which mechanisms, such as order processing, are responsible for deficient WM functioning in AD...
July 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28731429/severity-of-depression-impacts-imminent-conversion-from-mild-cognitive-impairment-to-alzheimer-s-disease
#4
Michaela Defrancesco, Josef Marksteiner, Georg Kemmler, Walter Wolfgang Fleischhacker, Imrich Blasko, Eberhard A Deisenhammer
BACKGROUND: Mild cognitive impairment (MCI) has been suggested to represent a prodromal stage of dementia and to confer a high risk for conversion to dementia Alzheimer's type (DAT). OBJECTIVES: In this study, we examined the predictive value of depressive symptoms and neuropsychological variables on conversion of MCI to DAT. METHODS: Neuropsychological and clinical follow-up data of 260 MCI patients seen at the Psychiatric Memory Clinic of the Medical University of Innsbruck between 2005 and 2015 were analyzed retrospectively...
July 19, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28726593/validation-and-normalization-of-the-tower-of-london-drexel-university-test-2nd-edition-in-an-adult-population-with-intellectual-disability
#5
Javier García-Alba, Susanna Esteba-Castillo, Miguel Ángel Castellanos López, Emili Rodríguez Hidalgo, Nuria Ribas Vidal, Fernando Moldenhauer Díaz, Ramón Novell-Alsina
Despite how important it is to assess executive functioning in persons with Intellectual Disability (ID), instruments adapted and validated for this population are scarce. This study's primary goal was to find evidence for the validity of the ID version of the Tower of London (TOLDXtm) test in persons with mild (IDMi) and moderate (IDMo) levels of ID with Down Syndrome (DS). A multicenter study was carried out. Subjects (n = 63, ≥ 39 years old) had DS with mild (n = 39) or moderate ID (n = 24) with no minor neurocognitive disorder or Alzheimer's disease...
July 20, 2017: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/28723964/development-of-the-korean-adult-reading-test-kart-to-estimate-premorbid-intelligence-in-dementia-patients
#6
Dahyun Yi, Eun Hyun Seo, Ji Young Han, Bo Kyung Sohn, Min Soo Byun, Jun Ho Lee, Young Min Choe, Suzy Ahn, Jong Inn Woo, Jongho Jun, Dong Young Lee
We aimed to develop a word-reading test for Korean-speaking adults using irregularly pronounced words that would be useful for estimation of premorbid intelligence. A linguist who specialized in Korean phonology selected 94 words that have irregular relationship between orthography and phonology. Sixty cognitively normal elderly (CN) and 31 patients with Alzheimer's disease (AD) were asked to read out loud the words and were administered the Wechsler Adult Intelligence Scale, 4th edition, Korean version (K-WAIS-IV)...
2017: PloS One
https://www.readbyqxmd.com/read/28721741/the-relevance-of-hippocampal-subfield-integrity-and-clock-drawing-test-performance-for-the-diagnosis-of-alzheimer-s-disease-and-mild-cognitive-impairment
#7
Dusan Hirjak, Fabio Sambataro, Barbara Remmele, Katharina M Kubera, Johannes Schröder, Ulrich Seidl, Anne K Thomann, Klaus H Maier-Hein, Robert C Wolf, Philipp A Thomann
OBJECTIVES: The clock drawing test (CDT) is one of the worldwide most used screening tests for Alzheimer's disease (AD). MRI studies have identified temporo-parietal regions being involved in CDT impairment. However, the contributions of the hippocampal formation to CDT performance in AD and mild cognitive impairment (MCI) have not been investigated so far. It is unclear whether morphological alterations or CDT score, or a combination of both, are able to predict AD. METHODS: 38 AD patients, 38 MCI individuals and 31 healthy controls underwent neuropsychological assessment and MRI at 3 Tesla...
July 19, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28715933/neuropsychological-tools-to-predict-conversion-from-amnestic-mild-cognitive-impairment-to-dementia-the-tredem-registry
#8
Maurizio Gallucci, Maria Elena Di Battista, Giuseppe Battistella, Chiara Falcone, Patrizia Silvia Bisiacchi, Enrico Di Giorgi
Most of the studies about conversion from Mild cognitive impairment (MCI) to dementia have focused on amnestic MCI (aMCI) which is considered a preclinical phase of Alzheimer's disease. The aim of the present study was to identify neuropsychological tools that would best predict conversion from aMCI to dementia. Fifty-five aMCI subjects on the Treviso Dementia Registry were investigated. They underwent a neuropsychological evaluation during their first assessment and again at follow-up. Cox proportional-hazard regression models were created to measure the association between the dependent variable (dementia diagnosis or MCI status maintenance) and the neuropsychological test scores at baseline...
July 18, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28714589/meg-biomarker-of-alzheimer-s-disease-absence-of-a-prefrontal-generator-during-auditory-sensory-gating
#9
Sanja Josef Golubic, Cheryl J Aine, Julia M Stephen, John C Adair, Janice E Knoefel, Selma Supek
Magnetoencephalography (MEG), a direct measure of neuronal activity, is an underexplored tool in the search for biomarkers of Alzheimer's disease (AD). In this study, we used MEG source estimates of auditory gating generators, nonlinear correlations with neuropsychological results, and multivariate analyses to examine the sensitivity and specificity of gating topology modulation to detect AD. Our results demonstrated the use of MEG localization of a medial prefrontal (mPFC) gating generator as a discrete (binary) detector of AD at the individual level and resulted in recategorizing the participant categories in (1) controls with mPFC generator localized in response to both the standard and deviant tones; (2) a possible preclinical stage of AD participants (a lower functioning group of controls) in which mPFC activation was localized to the deviant tone only; and (3) symptomatic AD in which mPFC activation was not localized to either the deviant or standard tones...
July 17, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28714354/is-cerebral-microbleed-prevalence-relevant-as-a-biomarker-in-amnestic-mild-cognitive-impairment-and-mild-alzheimer-s-disease
#10
Ana Gb Rabelo, Camila Vl Teixeira, Thamires Nc Magalhães, Ana Flávia Mk Carletti-Cassani, Augusto Cs Amato Filho, Helena Pg Joaquim, Leda L Talib, Orestes Forlenza, Patrícia Ao Ribeiro, Rodrigo Secolin, Iscia Lopes-Cendes, Fernando Cendes, Marcio Lf Balthazar
Introduction The search for a reliable neuroimaging biomarker in Alzheimer's disease is a matter of intense research. The presence of cerebral microbleeds seems to be a potential biomarker. However, it is not clear if the presence of microbleeds has clinical usefulness to differentiate mild Alzheimer's disease and amnestic mild cognitive impairment from normal aging. We aimed to verify if microbleed prevalence differs among three groups: mild Alzheimer's disease, amnestic mild cognitive impairment due to Alzheimer's disease, and normal controls...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28710524/altered-n100-potential-associates-with-working-memory-impairment-in-parkinson-s-disease
#11
Tua Annanmaki, Kirsi Palmu, Kari Murros, Juhani Partanen
The diagnosis of cognitive impairment and dementia often occurring with Parkinson's disease (PD) is still based on the clinical picture and neuropsychological examination. Ancillary methods to detect cognitive decline in these patients are, therefore, needed. Alterations in the latencies and amplitudes of evoked response potential (ERP) components N100 and P200 have been described in PD. Due to limited number of studies their relation to cognitive deficits in PD remains obscure. The present study was designed to examine if alterations in the N100- and P200-potentials associate with neuropsychological impairment in PD...
July 14, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28705033/differences-in-performance-in-camcog-r-domains-between-old-and-oldest-old-patients-with-alzheimer-s-disease
#12
B Canneti, A J Mosqueira, T Carreras, A B Gago-Veiga, C Onsurbe, M Ruiz, J Vivancos
The purpose of this study is to evaluate the neuropsychological performance in a ≥90-year-old population with Alzheimer disease (AD) in comparison with younger elderly patients. We retrospectively studied all patients with AD attended in a specialized clinic between 1999 and 2011. Age, sex, educational level, and sensory loss data were collected. Neuropsychological evaluation included Mini-Mental State Examination and Global Deterioration Scale. We used the eight Cambridge Cognitive Assessment (CAMCOG-R) domains to evaluate and compare the neuropsychological performance in the younger than 90 years old (<90) and older than 90 years old (≥90) groups...
July 13, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28702365/abnormal-amyloid-%C3%AE-42-expression-and-increased-oxidative-stress-in-plasma-of-ckd-patients-with-cognitive-dysfunction-a-small-scale-case-control-study-comparison-with-alzheimer-s-disease
#13
G Vinothkumar, C Kedharnath, S Krishnakumar, S Sreedhar, K Preethikrishnan, S Dinesh, A Sundaram, D Balakrishnan, G Shivashekar, Sureshkumar, P Venkataraman
BACKGROUND: Cognitive dysfunction has been increasingly recognized in chronic kidney disease (CKD) patients. Senile plaques are important pathophysiological characteristic of cognitive dysfunction. The major component of plaques is the amyloid β (Aβ) peptide released from proteolytic cleavage of amyloid precursor protein (APP). Plasma Aβ has been a focus of the growing literature on blood based biomarkers for cognitive dysfunction. Oxidative stress is prevalent in CKD and it plays an important role in cognitive dysfunction...
December 2017: BBA Clinical
https://www.readbyqxmd.com/read/28697555/subjective-cognitive-complaints-in-cognitively-healthy-older-adults-and-their-relationship-to-cognitive-performance-and-depressive-symptoms
#14
Hana Markova, Ross Andel, Hana Stepankova, Miloslav Kopecek, Tomas Nikolai, Jakub Hort, Catherine Thomas-Antérion, Martin Vyhnalek
BACKGROUND: Subjective cognitive complaints (SCCs) may be an early marker of prodromal Alzheimer's disease. OBJECTIVES: Using a 10-item yes/no SCCs questionnaire (Le Questionnaire de Plainte Cognitive [QPC]), we evaluated the prevalence and distribution of SCCs in cognitively healthy Czech older adults and examined total score and specific QPC items in relation to depressive symptomology and cognitive performance. METHODS: A sample of 340 cognitively healthy older community-dwelling volunteers aged 60 or older from the third wave of the longitudinal project National Normative Study of Cognitive Determinants of Healthy Aging, who underwent a comprehensive neuropsychological assessment and completed the QPC and the 15-item Geriatric Depression Scale (GDS-15)...
July 4, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28697554/egocentric-versus-allocentric-spatial-memory-in-behavioral-variant-frontotemporal-dementia-and-alzheimer-s-disease
#15
Sicong Tu, Hugo J Spiers, John R Hodges, Olivier Piguet, Michael Hornberger
BACKGROUND: Diagnosis of behavioral variant frontotemporal dementia (bvFTD) can be challenging, in particular when patients present with significant memory problems, which can increase the chance of a misdiagnosis of Alzheimer's disease (AD). Growing evidence suggests spatial orientation is a reliable cognitive marker able to differentiate these two clinical syndromes. OBJECTIVE: Assess the integrity of egocentric and allocentric heading orientation and memory in bvFTD and AD, and their clinical implications...
July 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28692710/association-of-plasma-total-tau-level-with-cognitive-decline-and-risk-of-mild-cognitive-impairment-or-dementia-in-the-mayo-clinic-study-on-aging
#16
Michelle M Mielke, Clinton E Hagen, Alexandra M V Wennberg, David C Airey, Rodolfo Savica, David S Knopman, Mary M Machulda, Rosebud O Roberts, Clifford R Jack, Ronald C Petersen, Jeffrey L Dage
Importance: The utility of plasma total tau level as a prognostic marker for cognitive decline and dementia is not well understood. Objectives: To determine (1) the association between plasma total tau level, cognitive decline, and risk of mild cognitive impairment (MCI) and dementia; (2) whether this association differs by the presence of elevated brain amyloid β (Aβ); and (3) whether plasma total tau level is associated with cognitive decline over a short interval of 15 months...
July 10, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28690632/neuropsychological-differences-related-to-age-in-dementia-with-lewy-bodies
#17
Yasuhiro Nagahama, Tomoko Okina, Norio Suzuki
BACKGROUND/AIMS: To examine the influence of age on neuropsychological performances in dementia with Lewy bodies (DLB) and Alzheimer disease (AD) patients. METHODS: We examined memory, executive, and visuo-constructional performances in 202 DLB patients and 236 AD patients. We divided the subjects into three age groups (65-74, 75-84, and 85-95 years old), and evaluated the differences in neuropsychological performances. RESULTS: Recent memory in the DLB group was significantly better than that in the age-matched AD group when comparing the age groups 65-74 years and 75-84 years; however, memory impairment in the DLB patients in the age group 85-95 years was comparable with that in the age-matched AD patients...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28689508/social-inappropriateness-in-neurodegenerative-disorders
#18
Philippe Desmarais, Krista L Lanctôt, Mario Masellis, Sandra E Black, Nathan Herrmann
BACKGROUND: New onset of mood and behavioral changes in middle-aged patients are frequently the first manifestations of an unrecognized neurocognitive disorder. Impairment of social cognition, the cognitive ability to process social information coming from others, such as emotions, to attribute mental states to others, and to respond appropriately to them, is often at the origin of behavioral manifestations in neurodegenerative disorders. METHODS: This paper reviews the current literature on social cognition impairment in neurocognitive disorders, particularly in prodromal stages of behavioral-variant frontotemporal dementia (bvFTD), Alzheimer's disease (AD), idiopathic Parkinson's disease (IPD), and Lewy body dementia (LBD)...
July 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28681740/cognition-in-advanced-normal-pressure-hydrocephalus-a-pilot-study-from-south-india
#19
Robert Mathew, Sauda Pavithran
BACKGROUND: Literature on cognition in normal pressure hydrocephalus (NPH) is sparse and more so on cognition in advanced NPH. OBJECTIVE: To study the cognitive profile in a hospital-based cohort of cognitively-advanced NPH. SETTINGS AND DESIGN: This was a prospective cross-sectional study. The patients included those availing dementia care service from three different tertiary care centres during a period of 5 years from 2010 to 2014. Patients were considered to have cognitively-advanced NPH if the Addenbrooke's Cognitive Examination(ACE) score was 50 or less...
July 2017: Neurology India
https://www.readbyqxmd.com/read/28675110/metabolic-regional-and-network-changes-in-alzheimer-s-disease-subtypes
#20
Karl Herholz, Cathleen Haense, Alex Gerhard, Matthew Jones, José Anton-Rodriguez, Shailendra Segobin, Julie S Snowden, Jennifer C Thompson, Christopher Kobylecki
Clinical variants of Alzheimer's disease (AD) include the common amnestic subtype as well as subtypes characterised by leading visual processing impairments or by multimodal neurocognitive deficits. We investigated regional metabolic patterns and networks between AD subtypes. The study comprised 9 age-matched controls and 25 patients with mild to moderate AD. Methods included clinical and neuropsychological assessment, high-resolution FDG PET and T1-weighted 3D MR imaging with PET-MR coregistration, grey matter segmentation, atlas-based regions-of-interest, linear mixed effects and regional correlation analysis...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
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