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https://www.readbyqxmd.com/read/29341070/personality-changes-during-the-transition-from-cognitive-health-to-mild-cognitive-impairment
#1
Richard J Caselli, Blake T Langlais, Amylou C Dueck, Bruce R Henslin, Travis A Johnson, Bryan K Woodruff, Charlene Hoffman-Snyder, Dona E C Locke
BACKGROUND/OBJECTIVES: Behavioral problems in individuals with Alzheimer's disease (AD) impose major management challenges. Current prevention strategies are anchored to cognitive outcomes, but behavioral outcomes may provide another, clinically relevant opportunity for preemptive therapy. We sought to determine whether personality changes that predispose to behavioral disorders arise during the transition from preclinical AD to mild cognitive impairment (MCI). DESIGN: Longitudinal observational cohort study...
January 17, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29332045/the-uniform-data-set-czech-version-normative-data-in-older-adults-from-an-international-perspective
#2
Tomas Nikolai, Hana Stepankova, Miloslav Kopecek, Zdenek Sulc, Martin Vyhnalek, Ondrej Bezdicek
BACKGROUND: Outside of the United States, international perspectives on normative data for neuropsychological test performance, within diverse populations, have been scarce. The neuropsychological test battery from the Uniform Data Set (UDS) of the Alzheimer's Disease Centers (ADC) program of the United States National Institute on Aging (NIA) is one of the most sensitive batteries for the evaluation of both normal cognitive aging and pathological cognitive decline. OBJECTIVE: This study aimed to determine the feasibility of the Czech Neuropsychological Test Battery from the Uniform Data Set (UDS-Cz 2...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29332036/relationships-between-lower-olfaction-and-brain-white-matter-lesions-in-elderly-subjects-with-mild-cognitive-impairment
#3
Juliette Heinrich, Jean-Sébastien Vidal, Axelle Simon, Anne-Sophie Rigaud, Olivier Hanon, Jacques Epelbaum, Cecile Viollet, Emmanuelle Duron
BACKGROUND: Olfactory impairment is reported in mild cognitive impairment (MCI) and Alzheimer's disease (AD) and is associated with hippocampal atrophy. In elderly people, dementia with AD neuropathology and white matter lesions (WML) is common. In this context, olfactory impairment could also depend on the presence of WML. OBJECTIVE: To assess the cross-sectional relationship between olfaction and WML in elderly subjects with MCI. METHODS: Consecutive subjects, >65 years old, diagnosed as MCI after a comprehensive neuropsychological assessment in an expert memory center, with a brain MRI performed within a year and without major depressive state, were included...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29329363/validity-of-teleneuropsychological-assessment-in-older-patients-with-cognitive-disorders
#4
Hannah E Wadsworth, Kaltra Dhima, Kyle B Womack, John Hart, Myron F Weiner, Linda S Hynan, C Munro Cullum
Objective: The feasibility and reliability of neuropsychological assessment at a distance have been demonstrated, but the validity of this testing medium has not been adequately demonstrated. The purpose of this study was to determine the ability of video teleconferencing administration of neuropsychological measures (teleneuropsychology) in discriminating cognitively impaired from non-impaired groups of older adults. It was predicted that measures administered via video teleconference would distinguish groups and that the magnitude of differences between impaired and non-impaired groups would be similar to group differences achieved in traditional administration...
January 10, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29319601/the-moca-memory-index-score-an-efficient-alternative-to-paragraph-recall-for-the-detection-of-amnestic-mild-cognitive-impairment
#5
Antarpreet Kaur, Steven D Edland, Guerry M Peavy
OBJECTIVE: To compare ability of 2 measures of delayed memory (word list, story paragraph) to discriminate Normal Control (NC) subjects from those with amnestic mild cognitive impairment (aMCI). METHODS: Demographic, neuropsychological, and diagnostic data contributed by 34 Alzheimer's Disease Centers to the National Alzheimer's Coordinating Center characterized 2717 individuals with a diagnosis of either NC (n=2205) or aMCI (n=512). The Montreal Cognitive Assessment-Memory Index Score (MoCA-MIS) assessed delayed word recall, and the Craft Story 21, delayed story recall...
January 9, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29307083/in-thai-nationals-the-apoe4-allele-affects-multiple-domains-of-neuropsychological-biobehavioral-and-social-functioning-thereby-contributing-to-alzheimer-s-disorder-while-the-apoe3-allele-protects-against-neuropsychiatric-symptoms-and-psychosocial-deficits
#6
Sookjaroen Tangwongchai, Thitiporn Supasitthumrong, Solaphat Hemrunroj, Chavit Tunvirachaisakul, Phenphichcha Chuchuen, Natnicha Houngngam, Thiti Snabboon, Ittipol Tawankanjanachot, Yuthachai Likitchareon, Kamman Phanthumchindad, Michael Maes
The apolipoprotein E epsilon 4 (ApoE4) allele is the strongest genetic risk factor for Alzheimer's disorder (AD) and is associated with semantic and episodic memory deficits. The aim of this study was to examine the associations between ApoE alleles (E2, E3, E4) and genotypes and neuropsychological tests, behavioral functions, and dementia symptoms as assessed using Consortium to Establish a Registry for Alzheimer's Disease (CERAD). This study included 60 patients with Alzheimer's disorder (AD), 60 with mild cognitive disorder (MCI), and 62 normal volunteers...
January 6, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29298174/reduced-walking-speed-in-subjective-and-mild-cognitive-impairment-a-cross-sectional-study
#7
Mari Kalland Knapstad, Ole Martin Steihaug, Mona Kristin Aaslund, Arne Nakling, Ingvill Fjell Naterstad, Tormod Fladby, Dag Aarsland, Lasse Melvaer Giil
BACKGROUND AND PURPOSE: Walking speed is reduced in people with dementia, but less is known about predementia conditions. We, therefore, studied the relationship between walking speed, cognition, and cerebrospinal fluid biomarkers in persons with subjective (SCI) and mild cognitive impairment (MCI). METHODS: We conducted a cross-sectional study of 22 healthy controls, 30 SCI and 17 MCI (N = 69). Walking speed was measured by a 10-m gait test at usual and fast pace...
January 2, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29296659/unmasking-the-benefits-of-donepezil-via-psychometrically-precise-identification-of-mild-cognitive-impairment-a-secondary-analysis-of-the-adcs-vitamin-e-and-donepezil-in-mci-study
#8
Emily C Edmonds, M Colin Ard, Steven D Edland, Douglas R Galasko, David P Salmon, Mark W Bondi
Introduction: Criteria for mild cognitive impairment (MCI) used in many clinical trials are susceptible to "false-positive (FP)" errors that can be avoided by an actuarial psychometric approach. Methods: Cluster analysis was applied to baseline neuropsychological test data from 756 MCI participants in the Alzheimer's Disease Cooperative Study donepezil trial. Treatment groups were compared after FP MCI cases were removed. Results: Cluster analyses revealed three groups: "single-domain amnestic MCI" (31%), "multi-domain amnestic MCI" (39%), and "FP MCI" (30%)...
2018: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29295652/long-lasting-neuropsychological-effects-of-a-computerized-cognitive-training-in-patients-affected-by-early-stage-alzheimer-s-disease-are-they-stable-over-time
#9
Marco Cavallo, Chiara Angilletta
INTRODUCTION: We investigated the stability of effects of a computerized cognitive training previously administered to a large group of early stage Alzheimer's disease (AD) patients, as compared with a control group. METHOD: Eighty AD patients were randomized in two groups and underwent a computerized cognitive training, or a control intervention. RESULTS: A Repeated Measures General Linear Model (RM-GLM) showed a significant interaction effect for the following neuropsychological tests: the digit span forward and backward, and the two-syllable words test, as measures of short-term memory and working memory; the Rivermead Behavioural Memory Test (RBMT) story immediate and the RBMT story delayed, as measures of ecologically oriented memory; the Token test, as measure of language comprehension; and the Brixton test, as an executive functions measure...
January 1, 2018: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29282641/the-efficacy-of-cognitive-intervention-in-mild-cognitive-impairment-mci-a-meta-analysis-of-outcomes-on-neuropsychological-measures
#10
REVIEW
Dale S Sherman, Justin Mauser, Miriam Nuno, Dean Sherzai
Cognitive training in MCI may stimulate pre-existing neural reserves or recruit neural circuitry as "compensatory scaffolding" prompting neuroplastic reorganization to meet task demands (Reuter-Lorenz & Park, 2014). However, existing systematic reviews and meta-analytic studies exploring the benefits of cognitive interventions in MCI have been mixed. An updated examination regarding the efficacy of cognitive intervention in MCI is needed given improvements in adherence to MCI diagnostic criteria in subject selection, better defined interventions and strategies applied, increased use of neuropsychological measures pre- and post-intervention, as well as identification of moderator variables which may influence treatment...
December 27, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/29282409/longitudinal-changes-in-performance-on-cognitive-screening-tests-in-patients-with-mild-cognitive-impairment-and-alzheimer-disease
#11
Fangzhou Li, Hajime Takechi, Atsuko Kokuryu, Ryosuke Takahashi
Background: Neuropsychological tests that can track changes in cognitive functions after diagnosis of Alzheimer disease (AD) and mild cognitive impairment (MCI), including episodic memory, should be further developed. Methods: The participants of our study consisted of 22 mild AD patients and 11 MCI patients. They were followed up for 2 years. Brief cognitive screening tests were administered to the participants. Longitudinal changes in test performance were evaluated and analyzed...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29282336/csf-neurofilament-light-chain-and-phosphorylated-tau-181-predict-disease-progression-in-psp
#12
Julio C Rojas, Jee Bang, Iryna V Lobach, Richard M Tsai, Gil D Rabinovici, Bruce L Miller, Adam L Boxer
OBJECTIVE: To determine the ability of CSF biomarkers to predict disease progression in progressive supranuclear palsy (PSP). METHODS: We compared the ability of baseline CSF β-amyloid1-42, tau, phosphorylated tau 181 (p-tau), and neurofilament light chain (NfL) concentrations, measured by INNO-BIA AlzBio3 or ELISA, to predict 52-week changes in clinical (PSP Rating Scale [PSPRS] and Schwab and England Activities of Daily Living [SEADL]), neuropsychological, and regional brain volumes on MRI using linear mixed effects models controlled for age, sex, and baseline disease severity, and Fisher F density curves to compare effect sizes in 50 patients with PSP...
December 27, 2017: Neurology
https://www.readbyqxmd.com/read/29278291/rating-scales-for-cognition-in-huntington-s-disease-critique-and-recommendations
#13
REVIEW
Tiago A Mestre, Anne-Catherine Bachoud-Lévi, Johan Marinus, Julie C Stout, Jane S Paulsen, Peter Como, Kevin Duff, Cristina Sampaio, Christopher G Goetz, Esther Cubo, Glenn T Stebbins, Pablo Martinez-Martin
Cognitive impairment is one of the main features of Huntington's disease and is present across the disease spectrum. As part of the International Parkinson's Disease and Movement Disorder Society-sponsored project to review all clinical rating scales used in Huntington's disease, a systematic review of the literature was performed to identify cognitive scales used in Huntington's disease and make recommendations for their use. A total of 17 cognitive scales were identified and evaluated. None of the scales met criteria for a "recommended" status...
December 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29275535/correction-to-detectable-neuropsychological-differences-in-early-preclinical-alzheimer-s-disease-a-meta-analysis
#14
S Duke Han, Caroline P Nguyen, Nikki H Stricker, Daniel A Nation
Errors were discovered in the reporting of processing speed data that do not impact the interpretation of findings.
December 23, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/29274595/florbetapir-pet-%C3%AE-amyloid-imaging-and-associated-neuropsychological-trajectories-in-survivors-of-critical-illness-a-case-series
#15
James C Jackson, Hillary J Warrington, Robert Kessler, Amy L Kiehl, E Wesley Ely
PURPOSE: Cognitive impairment resembling Alzheimer's disease is common in survivors of critical illness. We hypothesized that Intensive Care Unit (ICU) survivors with cognitive impairment would have significant amyloid and designed a pilot study to explore this relationship. MATERIALS AND METHODS: A pilot, case series of a convenience sample of 14 adult medical and surgical ICU survivors, in a clinical neuroradiology clinic. Patients underwent cognitive testing at 3months, 1year, 4years, and 6years after hospital discharge with the Repeatable Battery for the Assessment of Neuropsychological Status...
October 19, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29273521/the-pathology-and-pathophysiology-of-vascular-dementia
#16
REVIEW
Raj N Kalaria
Vascular dementia (VaD) is widely recognised as the second most common type of dementia. Consensus and accurate diagnosis of clinically suspected VaD relies on wide-ranging clinical, neuropsychological and neuroimaging measures in life but more importantly pathological confirmation. Factors defining subtypes of VaD include the nature and extent of vascular pathologies, degree of involvement of extra and intracranial vessels and the anatomical location of tissue changes as well as time after the initial vascular event...
December 19, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29249956/the-mirror-neurons-network-in-aging-mild-cognitive-impairment-and-alzheimer-disease-a-functional-mri-study
#17
Elisabetta Farina, Francesca Baglio, Simone Pomati, Alessandra D'Amico, Isabella C Campini, Sonia Di Tella, Giulia Belloni, Thierry Pozzo
The aim of the current study is to investigate the integrity of the Mirror Neurons (MN) network in normal aging, Mild Cognitive Impairment (MCI), and Alzheimer disease (AD). Although AD and MCI are considered "cognitive" diseases, there has been increasing recognition of a link between motor function and AD. More recently the embodied cognition hypothesis has also been developed: it postulates that a part of cognition results from the coupling between action and perception representations. MN represent a neuronal population which links perception, action, and cognition, therefore we decided to characterize MN functioning in neurodegenerative cognitive decline...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29247390/cognitive-impairment-in-celiac-disease-and-non-celiac-gluten-sensitivity-review-of-literature-on-the-main-cognitive-impairments-the-imaging-and-the-effect-of-gluten-free-diet
#18
REVIEW
Sinda Makhlouf, Mariem Messelmani, Jamel Zaouali, Ridha Mrissa
Celiac disease (CD) and non celiac gluten sensitivity (NCGS) can be responsible for neurological complications such as ataxia and peripheral neuropathies but also cognitive impairment. This cognitive involvement is variable in its expression, its duration and its prognosis ranging from transient and reversible subtle involvement to dementia itself. Through this article, we tried to achieve a review of the literature to better understand this topic. Several mechanisms were proposed to explain the deleterious influence of gluten-related pathologies on cognitive functions: nutritional deficiencies, elevation of circulating cytokine levels due to systemic inflammation, low brain serotonin levels… Several types of dementia such as Alzheimer dementia, vascular dementia, frontotemporal dementia were reported in association with CD...
December 15, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29246249/oligomeric-forms-of-amyloid-%C3%AE-protein-in-plasma-as-a-potential-blood-based-biomarker-for-alzheimer-s-disease
#19
Min Jeong Wang, SangHak Yi, Jee-Young Han, So Young Park, Jae-Won Jang, In Kook Chun, Sang Eun Kim, Byoung Sub Lee, Gwang Je Kim, Ji Sun Yu, Kuntaek Lim, Sung Min Kang, Young Ho Park, Young Chul Youn, Seong Soo A An, SangYun Kim
BACKGROUND: Soluble amyloid-β (Aβ) oligomers are the major toxic substances associated with the pathology of Alzheimer's disease (AD). The ability to measure Aβ oligomer levels in the blood would provide simple and minimally invasive tools for AD diagnostics. In the present study, the recently developed Multimer Detection System (MDS) for AD, a new enzyme-linked immunosorbent assay for measuring Aβ oligomers selectively, was used to detect Aβ oligomers in the plasma of patients with AD and healthy control individuals...
December 15, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29241403/social-support-and-verbal-interaction-are-differentially-associated-with-cognitive-function-in-midlife-and-older-age
#20
Megan L Zuelsdorff, Rebecca L Koscik, Ozioma C Okonkwo, Paul E Peppard, Bruce P Hermann, Mark A Sager, Sterling C Johnson, Corinne D Engelman
Social engagement is associated with healthy aging and preserved cognition. Two dimensions of engagement, verbal interactions and perceived support, likely impact cognition via distinct mechanistic pathways. We explored the cognitive benefit of each construct among enrollees (N = 1,052, mean age = 60.2 years) in the Wisconsin Registry for Alzheimer's Prevention study, who provide neuropsychological and sociobehavioral data at two-year intervals. Outcomes included six cognitive factor scores representing key domains of executive function and memory...
December 15, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
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