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https://www.readbyqxmd.com/read/28541543/validation-of-the%C3%A2-d%C3%A3-pistage-cognitif-de-qu%C3%A3-bec-a-new-cognitive-screening-tool-for-atypical-dementias
#1
Robert Laforce, Leila Sellami, David Bergeron, Audrey Paradis, Louis Verret, Marie-Pierre Fortin, Michèle Houde, Martin Roy, Stéphane Poulin, Joël Macoir, Carol Hudon, Rémi W Bouchard
Objective: This study aimed to validate and provide normative data for the Dépistage Cognitif de Québec (DCQ; www.dcqtest.org), a new cognitive screening tool for atypical dementias. Method: The DCQ was developed by expert behavioral neurologists and clinical neuropsychologists based on updated criteria for Alzheimer's disease, primary progressive aphasia, and behavioral variant frontotemporal dementia. It targets five relevant domains: Memory, Visuospatial, Executive, Language, and Behavior...
May 25, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28534796/predicting-progression-from-mild-cognitive-impairment-to-alzheimer-s-disease-using-autoregressive-modelling-of-longitudinal-and-multimodal-biomarkers
#2
Sidra Minhas, Aasia Khanum, Farhan Riaz, Shoab Khan, Atif Alvi
Mild Cognitive Impairment is a preclinical stage of Alzheimer's disease (AD). For effective treatment of AD, it is important to identify MCI patients who are at a high risk of developing AD over the course of time. İn this study, autoregressive modelling of multiple heterogeneous predictors of Alzheimer's dısease is performed to capture their evolution over time. The models are trained using three different arrangements of longitudinal data. These models are then used to estimate future biomarker readings of individual test subjects...
May 16, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28532271/prospective-memory-and-subjective-memory-decline-a-neuropsychological-indicator-of-memory-difficulties-in-community-dwelling-older-people
#3
Stephen D Lee, Ben Ong, Kerryn E Pike, Glynda J Kinsella
INTRODUCTION: Prospective memory difficulties are known to occur in Alzheimer's disease, and may provide an early indicator of cognitive decline. Older people reporting high levels of subjective memory decline (SMD) but without evidence of cognitive decline on standard neuropsychological tests are increasingly considered at increased risk for Alzheimer's disease. Therefore, the objective of this study was to investigate whether prospective memory performance is differentially impaired in older people reporting high levels of SMD as compared to a control group...
May 22, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28527215/diagnostic-and-prognostic-value-of%C3%A2-the%C3%A2-combination-of-two-measures-of%C3%A2-verbal-memory-in-mild-cognitive-impairment-due%C3%A2-to-alzheimer-s-disease
#4
Isabel Sala, Ignacio Illán-Gala, Daniel Alcolea, Ma Belén Sánchez-Saudinós, Sergio Andrés Salgado, Estrella Morenas-Rodríguez, Andrea Subirana, Laura Videla, Jordi Clarimón, María Carmona-Iragui, Roser Ribosa-Nogué, Rafael Blesa, Juan Fortea, Alberto Lleó
BACKGROUND: Episodic memory impairment is the core feature of typical Alzheimer's disease. OBJECTIVE: To evaluate the performance of two commonly used verbal memory tests to detect mild cognitive impairment due to Alzheimer's disease (MCI-AD) and to predict progression to Alzheimer's disease dementia (AD-d). METHODS: Prospective study of MCI patients in a tertiary memory disorder unit. Patients underwent an extensive neuropsychological battery including two tests of declarative verbal memory: The Free and Cued Selective Reminding Test (FCSRT) and the word list learning task from the Consortium to Establish a Registry for Alzheimer's disease (CERAD-WL)...
May 13, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28527210/cerebrospinal-fluid-biomarkers-and-clinical-progression-in-patients-with-subjective-cognitive-decline-and-mild-cognitive-impairment
#5
Steffen Wolfsgruber, Alexandra Polcher, Alexander Koppara, Luca Kleineidam, Lutz Frölich, Oliver Peters, Michael Hüll, Eckart Rüther, Jens Wiltfang, Wolfgang Maier, Johannes Kornhuber, Piotr Lewczuk, Frank Jessen, Michael Wagner
BACKGROUND: There is very limited data on the prevalence of abnormal cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and their predictive value for clinical progression in memory clinic patients with subjective cognitive decline (SCD). OBJECTIVE: To assess the frequency of abnormal CSF biomarkers of AD and their predictive value for clinical progression in memory clinic patients with SCD in comparison to patients with mild cognitive impairment (MCI) from the same cohort...
May 13, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28525567/saccadic-eye-movements-and-attentional-control-in-alzheimer-s-disease
#6
Nicolas Noiret, Nicolas Carvalho, Éric Laurent, Gilles Chopard, Mickaël Binetruy, Magali Nicolier, Julie Monnin, Eloi Magnin, Pierre Vandel
Objective: Several studies have demonstrated saccadic eye movement (SEM) abnormalities in Alzheimer's disease (AD) when patients performed prosaccade (PS) and antisaccade (AS) tasks. Some studies have also showed that SEM abnormalities were correlated with dementia rating tests such as the Mini Mental State Evaluation (MMSE). Therefore, it has been suggested that SEMs could provide useful information for diagnosis. However, little is known about predictive saccades (PreS)-saccades triggered before or very quickly after stimuli appearance-and their relationships with cognition in AD...
May 19, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28522971/altered-functional-connectivity-of-the-basal-nucleus-of-meynert-in-mild-cognitive-impairment-a-resting-state-fmri-study
#7
Hui Li, Xiuqin Jia, Zhigang Qi, Xiang Fan, Tian Ma, Hong Ni, Chiang-Shan R Li, Kuncheng Li
Background: Cholinergic dysfunction plays an important role in mild cognitive impairment (MCI). The basal nucleus of Meynert (BNM) provides the main source of cortical cholinergic innervation. Previous studies have characterized structural changes of the cholinergic basal forebrain in individuals at risk of developing Alzheimer's disease (AD). However, whether and how functional connectivity of the BNM (BNM-FC) is altered in MCI remains unknown. Objective: The aim of this study was to identify alterations in BNM-FC in individuals with MCI as compared to healthy controls (HCs), and to examine the relationship between these alterations with neuropsychological measures in individuals with MCI...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28515546/use-of-jonkman-et-al-score-for-visual-quantification-of-electroencephalography-as-a-tool-to-assess-disease-severity-in-cortical-dementias
#8
R Kiran Kumar, Sadanandavalli Retnaswami Chandra, Girish B Kulkarni, Rose Dawn Bharath
OBJECTIVES: To study electroencephalography (EEG) changes in patients with cortical dementias (Alzheimer's disease [AD] and frontotemporal dementia (FTD). (1) To correlate EEG changes with clinical severity of dementia as assessed by rating scales. (2) To correlate global gray matter volume (GGMV) with EEG scores and clinical severity rating scales. PATIENTS AND METHODS: This is a prospective cross-sectional study involving patients fulfilling the criteria for Probable AD and FTD...
March 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28511918/molecular-imaging-of-serotonin-degeneration-in-mild-cognitive-impairment
#9
Gwenn S Smith, Frederick S Barrett, Jin Hui Joo, Najlla Nassery, Alena Savonenko, Devin J Sodums, Christopher M Marano, Cynthia A Munro, Jason Brandt, Michael A Kraut, Yun Zhou, Dean F Wong, Clifford I Workman
Neuropathological and neuroimaging studies have consistently demonstrated degeneration of monoamine systems, especially the serotonin system, in normal aging and Alzheimer's disease. The evidence for degeneration of the serotonin system in mild cognitive impairment is limited. Thus, the goal of the present study was to measure the serotonin transporter in vivo in mild cognitive impairment and healthy controls. The serotonin transporter is a selective marker of serotonin terminals and of the integrity of serotonin projections to cortical, subcortical and limbic regions, as well as the cell bodies of origin (raphe nuclei)...
May 13, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28507319/longitudinal-changes-of-tau-pet-imaging-in-relation-to-hypometabolism-in-prodromal-and-alzheimer-s-disease-dementia
#10
K Chiotis, L Saint-Aubert, E Rodriguez-Vieitez, A Leuzy, O Almkvist, I Savitcheva, M Jonasson, M Lubberink, A Wall, G Antoni, A Nordberg
The development of tau-specific positron emission tomography (PET) tracers allows imaging in vivo the regional load of tau pathology in Alzheimer's disease (AD) and other tauopathies. Eighteen patients with baseline investigations enroled in a 17-month follow-up study, including 16 with AD (10 had mild cognitive impairment and a positive amyloid PET scan, that is, prodromal AD, and six had AD dementia) and two with corticobasal syndrome. All patients underwent PET scans with [(18)F]THK5317 (tau deposition) and [(18)F]FDG (glucose metabolism) at baseline and follow-up, neuropsychological assessment at baseline and follow-up and a scan with [(11)C]PIB (amyloid-β deposition) at baseline only...
May 16, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28507298/protective-effects-of-apoe-e2-against-disease-progression-in-subcortical-vascular-mild-cognitive-impairment-patients-a-three-year-longitudinal-study
#11
Yeo Jin Kim, Sang Won Seo, Seong Beom Park, Jin Ju Yang, Jin San Lee, Juyoun Lee, Young Kyoung Jang, Sung Tae Kim, Kyung-Han Lee, Jong Min Lee, Jae-Hong Lee, Jae Seung Kim, Duk L Na, Hee Jin Kim
Although the association between apolipoprotein E (APOE) genotype and disease progression is well characterized in patients with Alzheimer's disease, such a relationship is unknown in patients with subcortical vascular cognitive impairment. We evaluated whether APOE genotype is associated with disease progression in subcortical vascular mild cognitive impairment (svMCI) patients. We prospectively recruited 72 svMCI patients (19 APOE4 carriers, 42 APOE3 homozygotes, and 11 APOE2 carriers). Patients were annually followed-up with brain MRI and neuropsychological tests for three years and underwent a second Pittsburgh compound B (PiB)-PET at a mean interval of 32...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28502043/different-hippocampus-functional-connectivity-patterns-in-healthy-young-adults-with-mutations-of-app-presenilin-1-2-and-apoe%C3%AE%C2%B54
#12
Li Juan Zheng, Yun Yan Su, Yun Fei Wang, U Joseph Schoepf, Akos Varga-Szemes, Jonathan Pannell, Xue Liang, Gang Zheng, Guang Ming Lu, Gui Fen Yang, Long Jiang Zhang
This study aims to explore the hippocampus-based functional connectivity patterns in young, healthy APP and/or presenilin-1/2 mutation carriers and APOE ε4 subjects. Seventy-eight healthy young adults (33 male, mean age 24.0 ± 2.2 years; 18 APP and/or presenilin1/2 mutation carriers [APP/presenilin-1/2 group], 30 APOE ε4 subjects [APOE ε4 group], and 30 subjects without the above-mentioned genes [control group]) underwent resting-state functional MR imaging and neuropsychological assessments. Bilateral hippocampus functional connectivity patterns were compared among three groups...
May 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28497179/detectable-neuropsychological-differences-in-early-preclinical-alzheimer-s-disease-a-meta-analysis
#13
REVIEW
S Duke Han, Caroline P Nguyen, Nikki H Stricker, Daniel A Nation
The development of methods for in vivo detection of cerebral beta amyloid retention and tau accumulation have been increasingly useful in characterizing preclinical Alzheimer's disease (AD). While the association between these biomarkers and eventual AD has been demonstrated among cognitively intact older adults, the link between biomarkers and neurocognitive ability remains unclear. We conducted a meta-analysis to test the hypothesis that cognitively intact older adults would show statistically discernable differences in neuropsychological performance by amyloid status (amyloid negative = A-, amyloid positive = A+)...
May 11, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/28496183/everyday-cognition-scales-are-related-to-cognitive-function-in-the-early-stage-of-probable-alzheimer-s-disease-and-fdg-pet-findings
#14
Jung-Lung Hsu, Wen-Chuin Hsu, Chiung-Chih Chang, Kun-Ju Lin, Ing-Tsung Hsiao, Yen-Chun Fan, Chyi-Huey Bai
We applied the Everyday Cognition (ECog) scale in normal aging adults and patients with Alzheimer's disease (AD) to investigate associations between neuropsychological tests and neuroimaging markers. A total of 160 normal aging adults and 40 patients with the early stage of probable AD were included. Neuropsychological performance was assessed using the Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-NAB). (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans were used to measure AD-related hypometabolism...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28495939/apoe-e4-is-associated-with-gray-matter-loss-in-the-posterior-cingulate-cortex-in-healthy-elderly-controls-subsequently-developing-subtle-cognitive-decline
#15
S Haller, M-L Montandon, C Rodriguez, M Ackermann, F R Herrmann, P Giannakopoulos
BACKGROUND AND PURPOSE: The presence of apolipoprotein E4 (APOE*E4) is the strongest currently known genetic risk factor for Alzheimer disease and is associated with brain gray matter loss, notably in areas involved in Alzheimer disease pathology. Our objective was to assess the effect of APOE*E4 on brain structures in healthy elderly controls who subsequently developed subtle cognitive decline. MATERIALS AND METHODS: This prospective study included 382 community-dwelling elderly controls...
May 11, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28488297/frailty-in-older-adults-with-amnestic-mild-cognitive-impairment-as-a-result-of-alzheimer-s-disease-a-comparison-of-two-models-of-frailty-characterization
#16
Natália O C Cezar, Rafael Izbicki, Diego Cardoso, Jouce G Almeida, Leandro Valiengo, Marina V Z Camargo, Orestes V Forlenza, Monica S Yassuda, Ivan Aprahamian
AIM: To verify the prevalence and presence of frailty markers, and their relationship to cognitive function among older adults with amnestic mild cognitive impairment (aMCI). METHODS: This was an observational study with transversal analyses. Older adults with aMCI as a result of Alzheimer's disease (n = 40) were compared with healthy controls (n = 26) at the Psychogeriatric Outpatient Unit, Institute and Department of Psychiatry, Faculty of Medicine of the University of São Paulo...
May 10, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28487650/neuropsychological-testing-and-machine-learning-distinguish-alzheimer-s-disease-from-other-causes-for-cognitive-impairment
#17
Pavel Gurevich, Hannes Stuke, Andreas Kastrup, Heiner Stuke, Helmut Hildebrandt
With promising results in recent treatment trials for Alzheimer's disease (AD), it becomes increasingly important to distinguish AD at early stages from other causes for cognitive impairment. However, existing diagnostic methods are either invasive (lumbar punctures, PET) or inaccurate Magnetic Resonance Imaging (MRI). This study investigates the potential of neuropsychological testing (NPT) to specifically identify those patients with possible AD among a sample of 158 patients with Mild Cognitive Impairment (MCI) or dementia for various causes...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28487004/longitudinal-trajectories-of-informant-reported-daily-functioning-in-empirically-defined-subtypes-of-mild-cognitive-impairment
#18
Kelsey R Thomas, Emily C Edmonds, Lisa Delano-Wood, Mark W Bondi
OBJECTIVES: Within the Alzheimer's Disease Neuroimaging Initiative (ADNI)'s mild cognitive impairment (MCI) cohort, we previously identified MCI subtypes as well as participants initially diagnosed with MCI but found to have normal neuropsychological, biomarker, and neuroimaging profiles. We investigated the functional change over time in these empirically derived MCI subgroups. METHODS: ADNI MCI participants (n=654) were classified using cluster analysis as Amnestic MCI (single-domain memory impairment), Dysnomic MCI (memory+language impairments), Dysexecutive/Mixed MCI (memory+language+attention/executive impairments), or Cluster-Derived Normal (CDN)...
May 10, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28485663/can-8-months-of-daily-tdcs-application-slow-the-cognitive-decline-in-alzheimer-s-disease-a-case-study
#19
Martin Bystad, Ingrid Daae Rasmussen, Ole Grønli, Per M Aslaksen
This case study presents a patient with early-onset Alzheimer`s disease, who applied transcranial direct current stimulation (tDCS) daily for 8 consecutive months. This was a much higher frequency than previous tDCS studies. Neuropsychological assessments were conducted before the first tDCS session, after 5 months and after 8 months. After 8 months, the patient's immediate recall improved with 39%, whereas delayed recall improved 23%. Overall, the results revealed that patient's cognitive functions were stabilized...
May 9, 2017: Neurocase
https://www.readbyqxmd.com/read/28482688/subjective-cognitive-decline-in-preclinical-alzheimer-s-disease
#20
Laura A Rabin, Colette M Smart, Rebecca E Amariglio
Older adults with subjective cognitive decline (SCD) in the absence of objective neuropsychological dysfunction are increasingly viewed as at risk for non-normative cognitive decline and eventual progression to Alzheimer's disease (AD) dementia. The past decade has witnessed tremendous growth in research on SCD, which may reflect the recognition of SCD as the earliest symptomatic manifestation of AD. Yet methodological challenges associated with establishing common assessment and classification procedures hamper the construct...
May 8, 2017: Annual Review of Clinical Psychology
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