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https://www.readbyqxmd.com/read/28228653/drug-prescription-appropriateness-in-the-elderly-an-italian-study
#1
Nicola Allegri, Federica Rossi, Federica Del Signore, Paolo Bertazzoni, Roberto Bellazzi, Giorgio Sandrini, Tomaso Vecchi, Davide Liccione, Alessia Pascale, Stefano Govoni
PURPOSE: Correct drug prescription in the elderly is a difficult task that requires careful survey of the current pharmacological therapies. In this article, we reviewed the drug prescriptions provided to 860 persons aged 65 years or over, residing in a small city of Lombardy, Italy. METHODS: Subjects were recruited from a local nursing home, the Pavia and Vigevano Neuropsychological Center for Alzheimer's Disease, general practitioners' offices, and the local University of the Third Age...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28227897/predicting-rapid-cognitive-decline-in-alzheimer-s-disease-patients-using-quantitative-eeg-markers-and-neuropsychological-test-scores
#2
Carmina Reyes-Coronel, Markus Waser, Heinrich Garn, Manfred Deistler, Peter Dal-Bianco, Thomas Benke, Gerhard Ransmayr, Dieter Grossegger, Reinhold Schmidt, Carmina Reyes-Coronel, Markus Waser, Heinrich Garn, Manfred Deistler, Peter Dal-Bianco, Thomas Benke, Gerhard Ransmayr, Dieter Grossegger, Reinhold Schmidt, Carmina Reyes-Coronel, Gerhard Ransmayr, Dieter Grossegger, Markus Waser, Peter Dal-Bianco, Thomas Benke, Manfred Deistler, Reinhold Schmidt, Heinrich Garn
Alzheimer's Disease (AD) can take different courses: some patients remain relatively stable while others decline rapidly within a given period of time. Losing more than 3 Mini-Mental State Examination (MMSE) points in one year is classified as rapid cognitive decline (RCD). This study used neuropsychological test scores and quantitative EEG (QEEG) markers obtained at a baseline examination to identify if an AD patient will be suffering from RCD. Data from 68 AD patients of the multi-centric cohort study PRODEM-Austria were applied...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227768/measures-of-the-brain-functional-network-that-correlate-with-alzheimer-s-neuropsychological-test-scores-an-fmri-and-graph-analysis-study
#3
Soroosh Golbabaei, Amin Dadashi, Hamid Soltanian-Zadeh, Soroosh Golbabaei, Amin Dadashi, Hamid Soltanian-Zadeh, Soroosh Golbabaei, Amin Dadashi, Hamid Soltanian-Zadeh
Neural degeneration in Alzheimer's disease (AD) leads to structural topology deformation that in turn changes brain functionality. The main aim of the present study is to find the brain's functional connectivity network (FCN) correlates of Alzheimer's psychological test scores. To this end, the brain's FCN is extracted from the resting state functional magnetic resonance images (rs-fMRI) of healthy controls and patients with AD and represented as a graph. Then, network measures are calculated from the graphs...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227007/identification-of-blood-biomarkers-for-use-in-point-of-care-diagnosis-tool-for-alzheimer-s-disease
#4
E Jammeh, P Zhao, C Carroll, S Pearson, E Ifeachor, E Jammeh, P Zhao, C Carroll, S Pearson, E Ifeachor, C Carroll, E Jammeh, E Ifeachor, S Pearson, P Zhao
Early diagnosis of Alzheimer's Disease (AD) is widely regarded as necessary to allow treatment to be started before irreversible damage to the brain occur and for patients to benefit from new therapies as they become available. Low-cost point-of-care (PoC) diagnostic tools that can be used to routinely diagnose AD in its early stage would facilitate this, but such tools require reliable and accurate biomarkers. However, traditional biomarkers for AD use invasive cerebrospinal fluid (CSF) analysis and/or expensive neuroimaging techniques together with neuropsychological assessments...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222531/physical-exercise-with-music-maintains-activities-of-daily-living-in-patients-with-dementia-mihama-kiho-project-part-21
#5
Masayuki Satoh, Jun-Ichi Ogawa, Tomoko Tokita, Noriko Nakaguchi, Koji Nakao, Hirotaka Kida, Hidekazu Tomimoto
BACKGROUND: Recent studies suggest that combined non-pharmacological interventions are more beneficial than single interventions for primary and secondary prevention of dementia. We previously reported enhanced effects of physical exercise with music (ExM) on cognitive function in normal elderly people compared to exercise alone. OBJECTIVE: To identify if ExM improves cognitive function and activities of daily living (ADLs) in dementia patients over cognitive stimulation (CS)...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222504/bimanual-gesture-imitation-in-alzheimer-s-disease
#6
G Nter Sanin, Thomas Benke
BACKGROUND/OBJECTIVE: Unimanual gesture production or imitation has often been studied in Alzheimer's disease (AD) during apraxia testing. In the present study, it was hypothesized that bimanual motor tasks may be a sensitive method to detect impairments of motor cognition in AD due to increased demands on the cognitive system. METHODS: We investigated bimanual, meaningless gesture imitation in 45 AD outpatients, 38 subjects with mild cognitive impairment (MCI), and 50 normal controls (NC) attending a memory clinic...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222369/what-can-gait-tell-us-about-dementia-review-of-epidemiological-and-neuropsychological-evidence
#7
REVIEW
Vyara Valkanova, Klaus P Ebmeier
BACKGROUND: Cognitive impairment and gait disorders in people over the age of 65 represent major public health issues because of their high frequency, their link to poor outcomes and high costs. Research has demonstrated that these two geriatric syndromes are closely related. METHODS AND RESULTS: We aim to review the evidence supporting the relationship between gait and cognitive impairment, particularly focusing on epidemiological and neuropsychological studies in patients with Mild cognitive impairment, Alzheimer's disease and Vascular dementia...
February 9, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28213293/relations-between-personality-changes-and-cerebrospinal-fluid-biomarkers-of-alzheimer-s-disease-pathology
#8
D Tautvydaitė, J P Antonietti, H Henry, A von Gunten, J Popp
Specific changes in personality profiles may represent early non-cognitive symptoms of Alzheimer's disease (AD). Evaluating the subject's personality changes may add significant clinical information, as well as help to better understand the interaction between personality change, cognitive decline, and cerebral pathology. With this study we aimed to describe the relationship between personality changes and cerebrospinal fluid (CSF) markers of AD pathology at early clinical stages of the disease. One hundred and ten subjects, of whom 66 cognitively impaired patients (57 with mild cognitive impairment (MCI), and 9 with mild dementia) and 44 healthy controls, had neuropsychological examination as well as lumbar puncture to determine concentrations of CSF biomarkers of AD pathology (amyloid beta1-42 (Aβ1-42), phosphorylated tau (ptau-181), and total-tau (tau))...
February 4, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28208063/white-matter-lesions-and-the-cholinergic-deficit-in-aging-and-mild-cognitive-impairment
#9
Nils Richter, Anne Michel, Oezguer A Onur, Lutz Kracht, Markus Dietlein, Marc Tittgemeyer, Bernd Neumaier, Gereon R Fink, Juraj Kukolja
In Alzheimer's disease (AD), white matter lesions (WMLs) are associated with an increased risk of progression from mild cognitive impairment (MCI) to dementia, while memory deficits have, at least in part, been linked to a cholinergic deficit. We investigated the relationship between WML load assessed with the Scheltens scale, cerebral acetylcholinesterase (AChE) activity measured with [(11)C]N-methyl-4-piperidyl acetate PET, and neuropsychological performance in 17 patients with MCI due to AD and 18 cognitively normal older participants...
January 18, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28199994/association-between-montreal-cognitive-assessment-sub-item-scores-and-corresponding-cognitive-test-performance-in-patients-with-frontotemporal-dementia-and-related-disorders
#10
Kristy K L Coleman, Brenda L Coleman, Julia D MacKinley, Stephen H Pasternak, Elizabeth C Finger
The Montreal Cognitive Assessment (MoCA), a brief screening test developed to detect patients with mild cognitive impairment, is used in clinical settings across North America [Nasreddine et al.: J Am Geriatr Soc 2005;53:695-699]. The MoCA has been demonstrated to be sensitive to cognitive deficits in frontotemporal dementias (FTD) and related disorders [Coleman et al.: Alzheimer Dis Assoc Disord 2016;30:258-263]. Given attentional impairments in patients with FTD, whether and to what extent the abbreviated items on the MoCA may predict performance on corresponding assessments is not known...
February 16, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28187125/aerobic-exercise-for-alzheimer-s-disease-a-randomized-controlled-pilot-trial
#11
Jill K Morris, Eric D Vidoni, David K Johnson, Angela Van Sciver, Jonathan D Mahnken, Robyn A Honea, Heather M Wilkins, William M Brooks, Sandra A Billinger, Russell H Swerdlow, Jeffrey M Burns
BACKGROUND: There is increasing interest in the role of physical exercise as a therapeutic strategy for individuals with Alzheimer's disease (AD). We assessed the effect of 26 weeks (6 months) of a supervised aerobic exercise program on memory, executive function, functional ability and depression in early AD. METHODS AND FINDINGS: This study was a 26-week randomized controlled trial comparing the effects of 150 minutes per week of aerobic exercise vs. non-aerobic stretching and toning control intervention in individuals with early AD...
2017: PloS One
https://www.readbyqxmd.com/read/28183277/language-background-in-early-life-may-be-related-to-neuropsychiatry-symptoms-in-patients-with-alzheimer-disease
#12
Yi-Chien Liu, Jung-Lung Hsu, Shuu-Jin Wang, Ping-Keung Yip, Kenichi Meguro, Jong-Ling Fuh
BACKGROUND: The relationship between early life experience and the occurrence of neuropsychiatry symptoms (NPSs) in patients with Alzheimer disease (AD) is unclear. METHODS: From 2012 to 2014, we prospectively recruited 250 patients with probable AD from the memory clinic of Taipei Veterans General Hospital. All patients underwent standard assessments, including brain magnetic resonance imaging or computed tomography, neuropsychological tests, neuropsychiatry inventory (NPI-Q) and related blood tests...
February 10, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28179036/multiple-category-verbal-fluency-in-mild-cognitive-impairment-and-correlation-with-csf-biomarkers-for-alzheimer-s-disease
#13
Roberta M Mirandez, Ivan Aprahamian, Leda L Talib, Orestes V Forlenza, Marcia Radanovic
BACKGROUND: Verbal fluency (VF) tasks are widely used in neuropsychological evaluations, as a measure of executive/semantic dysfunction. The revised criteria for Alzheimer's disease (AD) diagnosis (National Institute on Aging and the Alzheimer Association, 2011) incorporating biomarkers has increased the interest in finding algorithms that combine neuropsychological and biomarkers features to better predict conversion from mild cognitive impairment (MCI) to AD. Our aim was to compare the most frequently used VF categories to determine which best discriminated cognitively healthy elderly from MCI patients, and whether cerebrospinal fluid (CSF) biomarkers levels (Aβ42, P-tau, T-tau, and Aβ42/P-tau) correlated with patient's performance in MCI...
February 9, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28167926/disrupted-causal-connectivity-anchored-in-the-posterior-cingulate-cortex-in-amnestic-mild-cognitive-impairment
#14
Hong Yang, Chengwei Wang, Yumei Zhang, Liming Xia, Zhan Feng, Deqiang Li, Shunliang Xu, Haiyan Xie, Feng Chen, Yushu Shi, Jue Wang
Amnestic mild cognitive impairment (aMCI) is a transitional stage between normal cognitive aging and Alzheimer's disease. Previous studies have found that neuronal activity and functional connectivity impaired in many functional networks, especially in the default mode network (DMN), which is related to significantly impaired cognitive and memory functions in aMCI patients. However, few studies have focused on the effective connectivity of the DMN and its subsystems in aMCI patients. The posterior cingulate cortex (PCC) is considered a crucial region in connectivity of the DMN and its key subsystem...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28161156/amyloid-beta-deposition-is-associated-with-increased-medial-temporal-lobe-activation-during-memory-encoding-in-the-cognitively-normal-elderly
#15
Kathryn Edelman, Dana Tudorascu, Christian Agudelo, Beth Snitz, Helmet Karim, Ann Cohen, Chester Mathis, Julie Price, Lisa Weissfeld, William Klunk, Howard Aizenstein
BACKGROUND: Much is unknown about changes that occur in the brain in the years preceding the cognitive and functional impairment associated with Alzheimer disease (AD). This period before mild cognitive impairment is present has been referred to as preclinical AD, and is thought to begin with amyloid-beta deposition and then progress to neurodegeneration and functional brain circuit alterations. Prior studies have shown that there is increased medial temporal lobe activation on functional magnetic resonance imaging (fMRI) early in the course of mild cognitive impairment...
January 19, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28161090/repetitive-transcranial-magnetic-stimulation-combined-with-cognitive-training-for-the-treatment-of-alzheimer-s-disease
#16
Jean-Paul Nguyen, Alcira Suarez, Gilles Kemoun, Michel Meignier, Estelle Le Saout, Philippe Damier, Julien Nizard, Jean-Pascal Lefaucheur
OBJECTIVE: To assess the efficacy of a combination of cognitive training (COG) and repetitive transcranial magnetic stimulation (rTMS), on cognitive performance, locomotor activity, apathy, caregiver burden and dependence of patients with Alzheimer's disease (AD). METHODS: A combination of COG and rTMS was performed in 10 patients with AD (NeuroAD procedure) for a period of 5weeks (one session per day, 5days a week), without maintenance sessions. Patients were evaluated at the end of the treatment (D45) and 6months later (M6) by the Mini Mental State Examination (MMSE), the Alzheimer disease assessment scale - cognitive subscale (ADAS-Cog), various neuropsychological tests and clinical scores specific for locomotor activity, apathy, caregiver burden, and dependence, recorded before the study (baseline)...
February 1, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28153054/interaction-between-personality-traits-and-cerebrospinal-fluid-biomarkers-of-alzheimer-s-disease-pathology-modulates-cognitive-performance
#17
Domilė Tautvydaitė, Deepti Kukreja, Jean-Philippe Antonietti, Hugues Henry, Armin von Gunten, Julius Popp
BACKGROUND: During adulthood, personality characteristics may contribute to the individual capacity to compensate the impact of developing cerebral Alzheimer's disease (AD) pathology on cognitive impairment in later life. In this study we aimed to investigate whether and how premorbid personality traits interact with cerebrospinal fluid (CSF) markers of AD pathology to predict cognitive performance in subjects with mild cognitive impairment or mild AD dementia and in participants with normal cognition...
February 2, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28152536/convergent-results-from-neuropsychology-and-from-neuroimaging-in-patients-with-mild-cognitive-impairment
#18
Carl Fredrik Eliassen, Ivar Reinvang, Per Selnes, Tormod Fladby, Erik Hessen
BACKGROUND/AIMS: To investigate the correspondence between neuropsychological single measures and variation in fludeoxyglucose positron emission tomography (FDG PET) glucose metabolism and magnetic resonance imaging (MRI) cortical thickness in mild cognitive impairment (MCI) patients. METHODS: Forty-two elderly controls and 73 MCI subjects underwent FDG PET and MRI scanning. Backward regression analyses with PET and MRI regions were used as dependent variables, while Rey Auditory Verbal Memory Test (RAVLT) recall, Trail Making Test B (TMT B), and a composite test score (RAVLT learning and immediate recall, TMT A, COWAT, and letter-number sequencing) were used as predictor variables...
February 3, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28152169/albuminuria-in-association-with-cognitive-function-and-dementia-a-systematic-review-and-meta-analysis
#19
Marios K Georgakis, Nikolaos G Dimitriou, Maria A Karalexi, Constantinos Mihas, Efthimia G Nasothimiou, Dimitrios Tousoulis, Georgios Tsivgoulis, Eleni Th Petridou
OBJECTIVES: Cerebral microvascular disease is considered to contribute to cognitive dysfunction. We opted to explore whether albuminuria, a marker of systemic microangiopathy, is associated with cognitive impairment, dementia, and cognitive function. DESIGN: Systematic review; independent reviewers screened 2359 articles, derived through the search strategy, for identification of observational studies quantifying an association of albuminuria with the outcomes of interest, abstracted data on study characteristics and results and evaluated studies on quality using the Newcastle-Ottawa scale...
February 2, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28151820/associations-between-impaired-cerebral-blood-flow-autoregulation-cerebral-oxygenation-and-biomarkers-of-brain-injury-and-postoperative-cognitive-dysfunction-in-elderly-patients-after-major-noncardiac-surgery
#20
Nicolai Goettel, Christoph S Burkhart, Ariane Rossi, Brenno C T Cabella, Manfred Berres, Andreas U Monsch, Marek Czosnyka, Luzius A Steiner
BACKGROUND: Increasing evidence links postoperative cognitive dysfunction (POCD) to surgery and anesthesia. POCD is recognized as an important neuropsychological adverse outcome in surgical patients, particularly the elderly. This prospective cohort study aimed to investigate whether POCD is associated with impaired intraoperative cerebral autoregulation and oxygenation, and increased levels of biomarkers of brain injury. METHODS: Study subjects were patients ≥65 years of age scheduled for major noncardiac surgery...
March 2017: Anesthesia and Analgesia
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