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Platelet lymphocyte ratio

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https://www.readbyqxmd.com/read/28732365/preoperative-neutrophil-to-lymphocyte-ratio-and-tumor-related-factors-to-predict-microvascular-invasion-in-patients-with-hepatocellular-carcinoma
#1
Yanlong Yu, Jiuling Song, Ran Zhang, Zhonghua Liu, Qiang Li, Ying Shi, Ying Chen, Jinming Chen
Small hepatocellular carcinoma (HCC) is less invasive and has a better prognosis, but it still has a high recurrence rate. Microvascular invasion (MVI), as a poor prognostic indicator, is of great importance for treating of patients with HCC. The objective of the present study was to evaluate the predictive value of preoperative neutrophil-to-lymphocyte ratio and possible clinical parameters to MVI in patients with HCC. A total of 157 operable patients with HCC having a tumor diameter of less than or equal to 5 cm were enrolled in this study...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28727131/evaluation-of-the-hematologic-system-as-a-marker-of-subclinical-inflammation-in-hyperemesis-gravidarum-a-case-control-study
#2
Fatma Beyazit, Filiz Halici Öztürk, Eren Pek, Mesut Abdülkerim Ünsal
OBJECTIVES: Current evidence suggests that subclinical inflammation plays a significant role in the development of hyperemesis gravidarum (HEG). Simple hematological markers, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have been shown to reflect inflammatory burden and disease activity in several disorders. This study aimed to determine the diagnostic value of these hematological parameters for HEG. MATERIAL AND METHODS: A total of 54 HEG patients and 58 age- and gestational-age-matched control subjects were studied...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28718070/platelet-lymphocyte-and-neutrophil-lymphocyte-ratios-are-prognostic-but-not-predictive-of-response-to-abiraterone-acetate-in-metastatic-castration-resistant-prostate-cancer
#3
A J Lozano Martínez, R Moreno Cano, S Escobar Páramo, R Salguero Aguilar, E Gonzalez Billalabeitia, R García Fernández, I De La Fuente Muñoz, A Romero Borque, M Porras Martínez, F Lopez Soler, E Cardenas Cánovas, I Ortega Martín
PURPOSE: Recently neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have been reported to be inflammatory parameters that confer poorer outcome in metastatic castration-resistant prostate cancer (mCPRPC). However, these ratios have not been analyzed in patients treated with abiraterone acetate. We explored the relationship between different values of PLR and NLR and survival in mCPRCP treated with abiraterone and their possible relation with a prostate specific antigen (PSA) response...
July 17, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28715072/association-of-mean-platelet-volume-with-presence-of-non-viable-myocardium-in-ischemic-cardiomyopathy
#4
Semi Ozturk, Ahmed Seyfettin Gürbüz, Süleyman Çağan Efe, Mehmet Fatih Yılmaz, Özden Savaş Den Hartigh, Ferahnaz Çınaral Sayın, Cevat Kırma
BACKGROUND AND AIMS: Parameters derived from complete blood count such as mean platelet volume (MPV), neutrophil to lymphocyte (NLR), platelet to lymphocyte (PLR) are recently proposed as measures of inflammation in addition to C-reactive protein (CRP), a classical inflammatory marker. Significant association of these parameters with atherosclerosis and complications have increasingly been reported. Our aim is to evaluate relationship between these parameters and presence of myocardial viability assessed with positron emission tomography (PET) in patients with ischemic cardiomyopathy...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28712557/age-modulates-the-relationship-between-platelet-to-lymphocyte-ratio-and-coronary-artery-disease
#5
Issada Trakarnwijitr, Bobby Li, Heath Adams, Jamie Layland, John Garlick, Andrew Wilson
BACKGROUND: Thrombocytosis and inflammation are vital elements in the pathogenesis of atherosclerosis. The platelet-to-lymphocyte ratio (PLR) is a novel biomarker that combines these parameters and has been shown to be associated with cardiovascular disease (CVD). This study aimed to determine whether PLR correlates with coronary artery disease (CAD) in high-risk patients, and if the relationship is affected by age. METHODS: Consecutive patients referred for coronary angiogram were evaluated (n=822)...
July 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28711490/long-term-response-to-sunitinib-treatment-in-metastatic-renal-cell-carcinoma-a-pooled-analysis-of-clinical-trials
#6
Nizar M Tannir, Robert A Figlin, Martin E Gore, M Dror Michaelson, Robert J Motzer, Camillo Porta, Brian I Rini, Caroline Hoang, Xun Lin, Bernard Escudier
BACKGROUND: We characterized clinical outcomes of patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib who were long-term responders (LTRs), defined as patients having progression-free survival (PFS) > 18 months. PATIENTS AND METHODS: A retrospective analysis of data from 5714 patients with mRCC treated with sunitinib in 8 phase II/III clinical trials and the expanded access program. Duration on-study and objective response rate (ORR) were compared between LTRs and patients with PFS ≤ 18 months ("others")...
June 20, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28710916/systemic-immune-inflammation-index-and-circulating-t-cell-immune-index-predict-outcomes-in-high-risk-acral-melanoma-patients-treated-with-high-dose-interferon
#7
Jiayi Yu, Xiaowen Wu, Huan Yu, Siming Li, LiLi Mao, Zhihong Chi, Lu Si, Xinan Sheng, Chuanliang Cui, Jie Dai, Meng Ma, Huan Tang, Tianxiao Xu, Junya Yan, Yan Kong, Jun Guo
High-dose interferon alfa-2b (IFN-α-2b) improves the survival of patients with high-risk melanoma. We aimed to identify baseline peripheral blood biomarkers to predict the outcome of acral melanoma patients treated with IFN-α-2b. Pretreatment baseline parameters and clinical data were assessed in 226 patients with acral melanoma. Relapse-free survival (RFS) and overall survival (OS) were assessed using the Kaplan-Meier method, and multivariate Cox regression analyses were applied after adjusting for stage, lactate dehydrogenase (LDH), and ulceration...
July 12, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28706446/derived-neutrophil-to-lymphocyte-ratio-and-monocyte-to-lymphocyte-ratio-may-be-better-biomarkers-for-predicting-overall-survival-of-patients-with-advanced-gastric-cancer
#8
Shubin Song, Chunfeng Li, Sen Li, Hongyu Gao, Xiuwen Lan, Yingwei Xue
BACKGROUND AND OBJECTIVES: Preoperative systemic inflammatory response and nutritional status play important roles in the tumorigenesis, progression, and prognosis of gastric cancer (GC). This research is designed to investigate the prognostic value of the biomarkers including the neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), and prognostic nutritional index (PNI) in predicting overall survival in patients with GC...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28706093/does-neutrophil-to-lymphocyte-ratio-predict-1-year-mortality-in-patients-with-primary-biliary-cholangitis-results-from-a-retrospective-study-with-validation-cohort
#9
Lin Lin, Meiyu Piao, Xihui Jiang, Houning Lv, Ningning Zhao, Fang Yang, Chao Sun
OBJECTIVES: Neutrophil-to-lymphocyte ratio (NLR) has been used to predict prognosis in various liver diseases, but its role in primary biliary cholangitis (PBC) is not clarified. We aimed to investigate the prognostic usefulness of NLR for 1-year mortality in PBC. METHODS: The study recruited a retrospective cohort with 88 patients with PBC and a prospective validation cohort with 63 participants who were followed-up for 1 year. NLR and other laboratory measurements were analysed by multivariate regression model for identifying independent factors for early mortality...
July 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28700514/low-volume-high-intensity-interval-versus-continuous-endurance-training-effects-on-hematological-and-cardiorespiratory-system-adaptations-in-professional-canoe-polo-athletes
#10
Mohsen Sheykhlouvand, Mohammadali Gharaat, Erfan Khalili, Hamid Agha-Alinejad, Farhad Rahmaninia, Hamid Arazi
The aim of this study was to compare the effect of two paddling-based high-intensity interval training (HIIT) and continuous endurance training (CET) on hematological, immunological, and cardiorespiratory adaptations in professional canoe polo athletes. Twenty one male canoe polo athletes were randomly divided into one of three groups (N=7): 1) HIIT with variable intensity (VIHIIT) (6×60-second at 100,110,120,130,130, 130,120,110,100% vV[Combining Dot Above]O2peak from 1 to 9 session respectively, 1:3 work to recovery ratio); 2) HIIT with variable volume (VVHIIT) (6,7,8,9,9,9,8,7,6 repetitions/session from 1 to 9 session respectively)×60-second at lowest velocity that elicited V[Combining Dot Above]O2peak (vV[Combining Dot Above]O2peak), 1:3 work to recovery ratio); and 3) the CET group performed 3 times × 60 min paddling sessions (75% vV[Combining Dot Above]O2peak) per week for 3 weeks...
July 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28697193/the-value-of-18-fdg-pet-ct-parameters-hematological-parameters-and-tumor-markers-in-predicting-kras-oncogene-mutation-in-colorectal-cancer
#11
Ali Ozan Oner, Evrim Surer Budak, Senay Yıldırım, Funda Aydın, Cem Sezer
OBJECTIVE: In this study we investigated the predictive value of maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), neutrophils/lymphocytes ratio (NLR), platelets/lymphocytes ratio (PLR), carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) in the prediction of KRAS gene mutation which plays an important role in the choice of treatment in colorectal cancer patients. SUBJECTS AND METHODS: A total of 55 cases with untreated colorectal cancer who had undergone both PET/CT examinations for initial staging and also mutation analysis of KRAS oncogene were studied...
July 12, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28694726/a-nationwide-multicentre-study-in-turkey-for-establishing-reference-intervals-of-haematological-parameters-with-novel-use-of-a-panel-of-whole-blood
#12
Yesim Ozarda, Kiyoshi Ichihara, Ebubekir Bakan, Harun Polat, Nurinnisa Ozturk, Nurcan K Baygutalp, Fatma Taneli, Yesim Guvenc, Murat Ormen, Zubeyde Erbayraktar, Nurten Aksoy, Hatice Sezen, Meltem Demir, Gulcin Eskandari, Gurbuz Polat, Nuriye Mete, Hatice Yuksel, Husamettin Vatansev, Fatma Gun, Okhan Akin, Ozlem Ceylan, Tevfik Noyan, Ozgul Gozlukaya, Yuksel Aliyazicioglu, Sevim Kahraman, Melahat Dirican, Gul Ozlem Tuncer, Shogo Kimura, Pinar Eker
INTRODUCTION: A nationwide multicentre study was conducted to establish well-defined reference intervals (RIs) of haematological parameters for the Turkish population in consideration of sources of variation in reference values (RVs). MATERIALS AND METHODS: K2-EDTA whole blood samples (total of 3363) were collected from 12 laboratories. Sera were also collected for measurements of iron, UIBC, TIBC, and ferritin for use in the latent abnormal values exclusion (LAVE) method...
June 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28685599/prognostic-potential-of-neutrophil-to-lymphocyte-ratio-and-lymphocyte-nadir-in-stage-iii-non-small-cell-lung-cancer
#13
Kylie H Kang, Jimmy T Efird, Neelesh Sharma, Michael Yang, Afshin Dowlati, Philip Linden, Mitchell Machtay, Tithi Biswas
AIM: Studies have shown increased pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios to be predictive of survival in various cancers. Our aim was to evaluate the prognostic role of such inflammatory markers in non-small-cell lung cancer (NSCLC). METHODS: One hundred and sixty-three patients with stage III NSCLC who received definitive treatment were included. Survival analysis was performed using Kaplan-Meier method. Hazard ratios for overall and recurrence-free survival were estimated using Cox proportional hazards model...
July 7, 2017: Future Oncology
https://www.readbyqxmd.com/read/28681683/coagulation-status-in-women-with-endometriosis
#14
Paola Viganò, Jessica Ottolina, Veronica Sarais, Giorgia Rebonato, Edgardo Somigliana, Massimo Candiani
Subtle alterations in coagulation and fibrinolysis have been recently reported in patients with endometriosis supporting a potential hypercoagulable status associated with the disease. This cross-sectional study aimed at evaluating some variables of coagulation status and inflammatory markers in women with endometriosis. A total of 314 women who underwent surgery were considered. The case group (n = 169) included patients with a surgical diagnosis of endometriosis, at any stage of disease. The control group (n = 145) included women with a surgical diagnosis of benign gynecologic pathology...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28681242/the-potential-role-of-platelets-in-the-consensus-molecular-subtypes-of-colorectal-cancer
#15
REVIEW
Michael Lam, Jason Roszik, Preeti Kanikarla-Marie, Jennifer S Davis, Jeffrey Morris, Scott Kopetz, David G Menter
The consensus molecular subtypes (CMS) in colorectal cancer (CRC) represent distinct molecular subcategories of disease as reflected by comprehensive molecular profiling. The four CMS subtypes represent unique biology. CMS1 represents high immune infiltration. CMS2 demonstrates upregulation of canonical pathways such as WNT signaling. Widespread metabolic changes are seen in CMS3. CMS4 represents a mesenchymal phenotype with hallmark features including complement activation, matrix remodeling, angiogenesis, epithelial-mesechymal transition (EMT), integrin upregulation and stromal infiltration...
July 6, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28681116/the-relationship-of-platelet-to-lymphocyte-ratio-and-neutrophil-to-monocyte-ratio-to-radiographic-grades-of-knee-osteoarthritis
#16
J Shi, W Zhao, H Ying, J Du, J Chen, S Chen, B Shen
OBJECTIVE: Accumulating data show that platelet to lymphocyte ratio (PLR) and neutrophil to monocyte ratio (NMR) undergo changes during inflammation in various diseases; however, the clinical features remain unclear in knee osteoarthritis (OA) patients. The purpose of our study was to evaluate PLR and NMR in knee OA patients, and assess their relationship to knee OA's radiographic grades. METHODS: A retrospective study on 132 adult knee OA patients and 162 healthy controls (HC) was performed...
July 5, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28678144/relationship-of-mean-platelet-volume-to-lymphocyte-ratio-and-coronary-collateral-circulation-in-patients-with-stable-angina-pectoris
#17
Ender Ornek, Alparslan Kurtul
BACKGROUND: In patients with coronary artery disease, coronary collateral circulation (CCC) develops as an adaptation to ischemia and contributes toward reduction of cardiovascular events. Recently, the mean platelet volume-to-lymphocyte ratio (MPVLR) has emerged as a novel and readily available marker of inflammation and thrombosis. This study aimed to investigate the relationship between MPVLR and development of CCC. PATIENTS AND METHODS: A total of 332 patients with stable angina pectoris undergoing coronary arteriography were enrolled and divided on the basis of the development of CCC into two groups: group with adequate CCC (n=243) and group with impaired CCC (n=89)...
July 3, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28676731/the-ratio-of-c-reactive-protein-albumin-is-a-novel-inflammatory-predictor-of-overall-survival-in-cisplatin-based-treated-patients-with-metastatic-nasopharyngeal-carcinoma
#18
Peng Sun, Cui Chen, Yi Xia, Xiwen Bi, Panpan Liu, Fei Zhang, Hang Yang, Xin An, Wenqi Jiang, Fenghua Wang
The C-reactive protein/albumin (CRP/Alb) ratio has been recently identified as a prognostic factor in various cancers, whereas its role remains unclear in metastatic nasopharyngeal carcinoma (NPC). The current study retrospectively analyzed 148 patients with metastatic NPC who underwent cisplatin-based chemotherapy and further evaluated the prognostic value of the CRP/Alb ratio and its association with clinical characteristics in these patients. The optimal cut-off value was 0.189 for the CRP/Alb ratio. The high CRP/Alb ratio was significantly associated with elevated NLR, platelet-to-lymphocyte ratio (PLR), and EBV-DNA levels and decreased haemoglobin level (all p < 0...
2017: Disease Markers
https://www.readbyqxmd.com/read/28673240/association-of-platelet-to-lymphocyte-ratio-with-non-culprit-atherosclerotic-plaque-vulnerability-in-patients-with-acute-coronary-syndrome-an-optical-coherence-tomography-study
#19
Xuedong Wang, Zulong Xie, Xinxin Liu, Xingtao Huang, Jiale Lin, Dan Huang, Bo Yu, Jingbo Hou
BACKGROUND: The platelet to lymphocyte ratio (PLR), an indirect inflammatory biomarker, has been recently demonstrated to be associated with severity of coronary artery disease. In the present study, we sought to investigate whether PLR is associated with vulnerable plaque characteristics of non-culprit lesions in patients with acute coronary syndrome (ACS). METHODS: The patients in our study were divided into two groups (high PLR group and low PLR group). A total of 119 non-culprit plaques from 71 patients with ACS were assessed by optical coherence tomography (OCT)...
July 3, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28647740/integrative-assessment-of-pretreatment-inflammation-nutrition-and-muscle-based-prognostic-markers-in-patients-with-muscle-invasive-bladder-cancer-undergoing-radical-cystectomy
#20
Makito Miyake, Yosuke Morizawa, Shunta Hori, Nagaaki Marugami, Kota Iida, Kenta Ohnishi, Daisuke Gotoh, Yoshihiro Tatsumi, Yasushi Nakai, Takeshi Inoue, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Nobumichi Tanaka, Keiji Shimada, Noboru Konishi, Kiyohide Fujimoto
OBJECTIVE: The present study evaluated the clinical relevance of an integrative preoperative assessment of inflammation-, nutrition-, and muscle-based markers for patients with muscle-invasive bladder cancer (MIBC) undergoing curative radical cystectomy (RC). METHODS: The analysis enrolled 117 patients and the variables included age, body mass index (BMI), neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, modified Glasgow Prognostic Score (mGPS), prognostic nutritional index (PNI), Controlling Nutritional Status score, psoas muscle index (PMI), and peak expiratory flow (PEF)...
June 24, 2017: Oncology
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