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https://www.readbyqxmd.com/read/28098460/sulfate-mediated-end-to-end-assembly-of-gold-nanorods
#1
Seyyed Mohammad Hossein Abtahi, Nathan D Burrows, Fred A Idesis, Catherine J Murphy, Navid B Saleh, Peter J Vikesland
There is interest in the controlled aggregation of gold nanorods (GNRs) for the production of extended nanoassemblies. Prior studies have relied upon chemical modification of the GNR surface to achieve a desired final aggregate structure. Herein, we illustrate that control of electrolyte composition can facilitate end-to-end assembly of cetyltrimethylammonium bromide (CTAB) coated GNRs. By adjusting either the sulfate anion concentration or the exposure time it is possible to connect GNRs in chain-like assemblies...
January 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28098310/a-computational-model-predicts-genetic-nodes-that-allow-switching-between-species-specific-responses-in-a-conserved-signaling-network
#2
Adriana T Dawes, David Wu, Karley K Mahalak, Edward M Zitnik, Natalia Kravtsova, Haiwei Su, Helen M Chamberlin
Cell signaling networks regulate a variety of developmental and physiological processes, and changes in their response to external stimuli are often implicated in disease initiation and progression. To elucidate how different responses can arise from conserved signaling networks, we have developed a mathematical model of the well-characterized Caenorhabditis vulval development network involving EGF, Wnt and Notch signaling that recapitulates biologically observed behaviors. We experimentally block a specific element of the EGF pathway (MEK), and find different behaviors in vulval development in two Caenorhabditis species, C...
January 18, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28094490/urinary-incontinence-in-women-non-pharmacologic-approaches-and-newer-pharmacotherapies-an-update
#3
Casey G Kowalik, Joshua A Cohn, Alex Gomelsky, Roger R Dmochowski
Urinary incontinence is a widespread problem for women, with stress urinary incontinence (SUI) being the most common type. An updated review of PubMed literature using the following keywords was performed: stress urinary incontinence, women, midurethral slings, bulking agents, pubovaginal slings, retropubic suspension, postoperative complications, and treatment outcome. More recent publications, systematic reviews, and meta-analyses were given preference. The aging population will increase the demand for care of women with SUI...
January 17, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28094392/3d-printing-of-self-assembling-thermoresponsive-nanoemulsions-into-hierarchical-mesostructured-hydrogels
#4
Lilian C Hsiao, Abu Zayed Md Badruddoza, Li-Chiun Cheng, Patrick S Doyle
Spinodal decomposition and phase transitions have emerged as viable methods to generate a variety of bicontinuous materials. Here, we show that when arrested phase separation is coupled to the time scales involved in three-dimensional (3D) printing processes, hydrogels with multiple length scales spanning nanometers to millimeters can be printed with high fidelity. We use an oil-in-water nanoemulsion-based ink with rheological and photoreactive properties that satisfy the requirements of stereolithographic 3D printing...
January 17, 2017: Soft Matter
https://www.readbyqxmd.com/read/28093973/adsorptive-removal-of-metal-ions-from-water-using-functionalized-biomaterials
#5
Kanchanmala Deshpande
BACKGROUND: Synthesis and modification of cost-effective sorbents for removing heavy metals from water resources is an area of significance. It had been reported that materials with biological origins, such as agricultural and animal waste, are excellent alternatives to conventional adsorbents due to their higher affinity, capacity and selectivity towards metal ions. These properties of biomaterials help to reduce or detoxify metal ions concentration in contaminated water to acceptable regulatory standards...
January 16, 2017: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/28090036/fabrication-and-functionalization-of-inorganic-materials-using-amphiphilic-molecules
#6
Hirobumi Shibata
In this review, the synthesis of inorganic materials with various properties using amphiphilic molecules is examined. Amphiphilic molecules are used for the formation of highly ordered mesostructures and the surface modification. Two examples of the mesostructures are crystalline mesoporous titania (TiO2) and the novel visible light responsive mesostuructured titania modified with dye in the pores, which can be fabricated using the molecular self-assemblies of amphiphiles as templates. Surface modification using amphiphilic molecules enables the construction of self-assembled arrays of silica particles and the preparation of a film that can control adsorption/desorption behavior of bovine serum albumin (BSA) by light irradiation...
January 16, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28087979/rapid-antidepressant-effect-of-ketamine-correlates-with-astroglial-plasticity-in-the-hippocampus
#7
Maryam Ardalan, Ali H Rafati, Jens R Nyengaard, Gregers Wegener
BACKGROUND AND PURPOSE: Astroglia contributes to the pathophysiology of major depression and the action of antidepressant drugs through modulating synaptic plasticity; therefore, present study investigated whether fast antidepressant action of ketamine is reflected in the rapid alteration of the astrocytes morphology in a genetic animal model of depression. EXPERIMENTAL APPROACH: S-Ketamine (15 mg/kg) or saline was administered as a single injection to Flinders Line (FSL/FRL) rats...
January 14, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28087354/effect-of-piroxicam-on-lipid-membranes-drug-encapsulation-and-gastric-toxicity-aspects
#8
Natalia Wilkosz, Sami Rissanen, Małgorzata Cyza, Renata Szybka, Maria Nowakowska, Alex Bunker, Tomasz Róg, Mariusz Kepczynski
Uptake of piroxicam, a non-steroidal anti-inflammatory drug, from the intestines after oral intake is limited due to its low solubility and its wide use is associated with several side effects related to the gastrointestinal tract. In this study, all-atom molecular dynamics (MD) simulations and fluorescent spectroscopy were employed to investigate the interaction of piroxicam in neutral, zwitterionic, and cationic forms with lipid bilayers composed of phosphatidylcholine, cholesterol, and PEGylated lipids. Our study was aimed to assess the potential for encapsulation of piroxicam in liposomal carriers and to shed more light on the process of gastrointestinal tract injury by the drug...
January 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28079616/evaluation-of-an-outpatient-rehabilitative-program-to-address-mobility-limitations-among-older-adults
#9
Lorna G Brown, Meng Ni, Catherine T Schmidt, Jonathan F Bean
Live Long Walk Strong is a clinical demonstration program for community-dwelling older patients. It was designed to be consistent with current fall prevention guidelines and reimbursed under the Medicare model. Patients were screened within primary care and referred to a physiatrist followed by systematic assessment and treatment within an outpatient rehabilitative care setting. The treatment included behavioral modification, fall prevention education, community/home exercise integration, and exercise targeting strength, power, flexibility, balance, and endurance...
January 11, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28079355/self-assembled-architectures-of-alkynylplatinum-ii-amphiphiles-and-their-structural-optimization-a-balance-of-the-interplay-among-pt%C3%A2-%C3%A2-%C3%A2-pt-%C3%AF-%C3%AF-stacking-and-hydrophobic-hydrophobic-interactions
#10
Heidi Li-Ki Fu, Charlotte Po, Sammual Yu-Lut Leung, Vivian Wing-Wah Yam
A series of alkynylplatinum(II) terpyridine complexes with triethylene glycol units was synthesized, and their self-assembly properties were investigated in solution by UV-vis absorption, emission, and (1)H NMR spectroscopy. The aggregation behaviors of several water-soluble complexes were investigated in aqueous media. Some of them were found to give rise to uniform fibers, suggesting the important role that triethylene glycol units has in regulating their self-assembly properties. Further modifications of these structures through the incorporation of alkyl chains and changes in counter-anions have rendered the complexes more amphiphilic in nature, and the effect of their alkyl chain lengths was studied and optimized...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28075561/selective-tuning-of-elastin-like-polypeptide-properties-via-methionine-oxidation
#11
Rosine Petitdemange, Elisabeth Garanger, Laure Bataille, Katell Bathany, Bertrand Garbay, Timothy J Deming, Sebastien Lecommandoux
We have designed and prepared a recombinant elastin-like polypeptide (ELP) containing precisely positioned methionine residues, and performed the selective and complete oxidation of its methionine thioether groups to both sulfoxide and sulfone derivatives. Since these oxidation reactions substantially increase methionine residue polarity, they were found to be a useful means to precisely adjust the temperature responsive behavior of ELPs in aqueous solutions. In particular, lower critical solution temperatures were found to be elevated in oxidized sample solutions, but were not eliminated...
January 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28075346/automated-surveillance-of-fruit-flies
#12
Ilyas Potamitis, Iraklis Rigakis, Nicolaos-Alexandros Tatlas
Insects of the Diptera order of the Tephritidae family cause costly, annual crop losses worldwide. Monitoring traps are important components of integrated pest management programs used against fruit flies. Here we report the modification of typical, low-cost plastic traps for fruit flies by adding the necessary optoelectronic sensors to monitor the entrance of the trap in order to detect, time-stamp, GPS tag, and identify the species of incoming insects from the optoacoustic spectrum analysis of their wingbeat...
January 8, 2017: Sensors
https://www.readbyqxmd.com/read/28074747/liraglutide-a-glucagon-like-peptide-1-agonist-for-chronic-weight-management
#13
Kendra R Manigault, Maria Miller Thurston
OBJECTIVE: To review the efficacy and safety of liraglutide 3.0 mg for weight loss. DATA SOURCE: A literature search was performed using PubMed and MEDLINE from 2000 to 2016. The following key terms were used alone or in combination: glucagon-like peptide-1 agonist, liraglutide, obesity, overweight, and weight loss. Additional supporting literature was identified utilizing the reference lists of the preceding articles. STUDY SELECTION: Analyzed studies were published in English and investigated use of liraglutide and its impact on weight loss...
December 1, 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28073958/rudeness-and-medical-team-performance
#14
Arieh Riskin, Amir Erez, Trevor A Foulk, Kinneret S Riskin-Geuz, Amitai Ziv, Rina Sela, Liat Pessach-Gelblum, Peter A Bamberger
OBJECTIVES: Rudeness is routinely experienced by medical teams. We sought to explore the impact of rudeness on medical teams' performance and test interventions that might mitigate its negative consequences. METHODS: Thirty-nine NICU teams participated in a training workshop including simulations of acute care of term and preterm newborns. In each workshop, 2 teams were randomly assigned to either an exposure to rudeness (in which the comments of the patient's mother included rude statements completely unrelated to the teams' performance) or control (neutral comments) condition, and 2 additional teams were assigned to rudeness with either a preventative (cognitive bias modification [CBM]) or therapeutic (narrative) intervention...
January 10, 2017: Pediatrics
https://www.readbyqxmd.com/read/28073834/dynamic-and-coordinated-single-molecular-interactions-at-tm4sf5-enriched-microdomains-guide-invasive-behaviors-in-2-and-3-dimensional-environments
#15
Hye-Jin Kim, Sojung Kwon, Seo Hee Nam, Jae Woo Jung, Minkyung Kang, Jihye Ryu, Ji Eon Kim, Jin-Gyu Cheong, Chang Yun Cho, Somi Kim, Dae-Geun Song, Yong-Nyun Kim, Tai Young Kim, Min-Kyo Jung, Kyung-Min Lee, Chan-Gi Pack, Jung Weon Lee
Membrane proteins sense extracellular cues and transduce intracellular signaling to coordinate directionality and speed during cellular migration. They are often localized to specific regions, as with lipid rafts or tetraspanin-enriched microdomains; however, the dynamic interactions of tetraspanins with diverse receptors within tetraspanin-enriched microdomains on cellular surfaces remain largely unexplored. Here, we investigated effects of tetraspan(in) TM4SF5 (transmembrane 4 L six family member 5)-enriched microdomains (T5ERMs) on the directionality of cell migration...
January 10, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28073732/insecticide-resistance-in-anopheles-mosquitoes%C3%A2-additional-obstacles-in-the-battle-against-malaria
#16
A Rubert, L Guillon-Grammatico, J Chandenier, I Dimier-Poisson, G Desoubeaux
Mosquitoes of the genus Anopheles are malaria vectors in tropical areas and were of course designated as primary targets by programs for malaria control. Repellent sprays, indoor use of insecticides, and massive delivery of mosquito nets are standard examples of the means widely used to combat malaria. This synthetic review supplies an overview of all of the modes of resistance developed by Anopheles mosquitoes against these human actions. The misuse of each available tool has gradually led to a decrease in its global effectiveness...
November 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28071595/hybrid-3d-2d-printing-for-bone-scaffolds-fabrication
#17
V A Seleznev, V Ya Prinz
It is a well-known fact that bone scaffold topography on micro- and nanometer scale influences the cellular behavior. Nano-scale surface modification of scaffolds allows the modulation of biological activity for enhanced cell differentiation. To date, there has been only a limited success in printing scaffolds with micro- and nano-scale features exposed on the surface. To improve on the currently available imperfect technologies, in our paper we introduce new hybrid technologies based on a combination of 2D (nano imprint) and 3D printing methods...
January 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28070121/nrsf-dependent-epigenetic-mechanisms-contribute-to-programming-of-stress-sensitive-neurons-by-neonatal-experience-promoting-resilience
#18
A Singh-Taylor, J Molet, S Jiang, A Korosi, J L Bolton, Y Noam, K Simeone, J Cope, Y Chen, A Mortazavi, T Z Baram
Resilience to stress-related emotional disorders is governed in part by early-life experiences. Here we demonstrate experience-dependent re-programming of stress-sensitive hypothalamic neurons, which takes place through modification of neuronal gene expression via epigenetic mechanisms. Specifically, we found that augmented maternal care reduced glutamatergic synapses onto stress-sensitive hypothalamic neurons and repressed expression of the stress-responsive gene, Crh. In hypothalamus in vitro, reduced glutamatergic neurotransmission recapitulated the repressive effects of augmented maternal care on Crh, and this required recruitment of the transcriptional repressor repressor element-1 silencing transcription factor/neuron restrictive silencing factor (NRSF)...
January 10, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28069555/self-assembled-protein-nanocarrier-for-intracellular-delivery-of-antibody
#19
Sung In Lim, Cyril I Lukianov, Julie A Champion
Despite the great potential of antibodies as intracellular therapeutics, there is a significant, unmet challenge in delivering sufficient amounts of folded antibodies inside cells. We describe an all-protein self-assembled nanocarrier capable of delivering functional antibodies to the cytosol. By combining an α-helical peptide that self-assembles into a hexameric coiled-coil bundle and an Fc-binding Protein A fragment, we generated the Hex nanocarrier that is efficiently internalized by cells without cytotoxicity...
January 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28067775/the-impact-of-transformational-leadership-on-safety-climate-and-individual-safety-behavior-on-construction-sites
#20
Yuzhong Shen, Chuanjing Ju, Tas Yong Koh, Steve Rowlinson, Adrian J Bridge
Unsafe acts contribute dominantly to construction accidents, and increasing safety behavior is essential to reduce accidents. Previous research conceptualized safety behavior as an interaction between proximal individual differences (safety knowledge and safety motivation) and distal contextual factors (leadership and safety climate). However, relatively little empirical research has examined this conceptualization in the construction sector. Given the cultural background of the sample, this study makes a slight modification to the conceptualization and views transformational leadership as an antecedent of safety climate...
January 5, 2017: International Journal of Environmental Research and Public Health
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