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https://www.readbyqxmd.com/read/29227723/interventions-to-address-sexual-problems-in-people-with-cancer-american-society-of-clinical-oncology-clinical-practice-guideline-adaptation-of-cancer-care-ontario-guideline
#1
Jeanne Carter, Christina Lacchetti, Barbara L Andersen, Debra L Barton, Sage Bolte, Shari Damast, Michael A Diefenbach, Katherine DuHamel, Judith Florendo, Patricia A Ganz, Shari Goldfarb, Sigrun Hallmeyer, David M Kushner, Julia H Rowland
Purpose The adaptation of the Cancer Care Ontario (CCO) guideline Interventions to Address Sexual Problems in People With Cancer provides recommendations to manage sexual function adverse effects that occur as a result of cancer diagnosis and/or treatment. Methods ASCO staff reviewed the guideline for developmental rigor and updated the literature search. An ASCO Expert Panel ( Table A1 ) was assembled to review the guideline content and recommendations. Results The ASCO Expert Panel determined that the recommendations from the 2016 CCO guideline are clear, thorough, and based upon the most relevant scientific evidence...
December 11, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29227391/the-role-of-the-faith-community-nurse-in-weight-management
#2
Sabrina Kelley
Over two thirds of U.S. adults are overweight or obese; many view long-term behavior change as unachievable. Faith community nurses are ideally positioned to help people learn strategies for successful weight management. This article discusses the role of faith in lifestyle modification, and the use of the 5 A's Model for weight management.
January 2018: Journal of Christian Nursing: a Quarterly Publication of Nurses Christian Fellowship
https://www.readbyqxmd.com/read/29223644/functional-significance-of-o-glcnac-modification-in-regulating-neuronal-properties
#3
REVIEW
Hongik Hwang, Hyewhon Rhim
Post-translational modifications (PTMs) covalently modify proteins and diversify protein functions. Along with protein phosphorylation, another common PTM is the addition of O-linked β-N-acetylglucosamine (O-GlcNAc) to serine and/or threonine residues. O-GlcNAc modification is similar to phosphorylation in that it occurs to serine and threonine residues and cycles on and off with a similar time scale. However, a striking difference is that the addition and removal of the O-GlcNAc moiety on all substrates are mediated by the two enzymes regardless of proteins, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), respectively...
December 6, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29222842/kinetic-characterisation-of-wild-type-and-mutant-human-thioredoxin-glutathione-reductase-defines-its-reaction-and-regulatory-mechanisms
#4
Christina Brandstaedter, Karin Fritz-Wolf, Stine Weder, Marina Fischer, Beate Hecker, Stefan Rahlfs, Katja Becker
In most cells the thioredoxin (Trx) and glutathione systems are essentially involved in maintaining redox homeostasis. The selenoprotein thioredoxin glutathione reductase (TGR) is a hybrid enzyme in which a glutaredoxin (Grx) domain is linked to a thioredoxin reductase (TrxR). Notably, the protein is also capable of reducing glutathione disulfide (GSSG) thus representing an important link between the two redox systems. In this study, we recombinantly produced human TGR (hTGR wild type) by fusing its open reading frame with a bacterial SECIS element and co-expressing the construct in E...
December 8, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29222774/preparation-of-adult-rat-sensory-neuron-cultures-and-their-application-to-growth-cone-turning-assays
#5
Christine A Webber, Douglas W Zochodne
The directional trajectory of growing peripheral nerve axons in the adult impacts their successful regeneration to denervated target tissues. Misdirected axons in neuromas, injured nerve trunks, or nerves with attempted repair diminish the success of regeneration. The behavior of adult rodent peripheral sensory neurons in vitro, in turn, is helpful in predicting axonal behavior in vivo. Here, we describe the adaptation of embryonic neuron growth cone turning assays, an important technique in developmental neurobiology, to adult rat sensory neurons...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222089/core-binding-factor-%C3%AE-and-runx-transcription-factors-promote-adaptive-natural-killer-cell-responses
#6
Moritz Rapp, Colleen M Lau, Nicholas M Adams, Orr-El Weizman, Timothy E O'Sullivan, Clair D Geary, Joseph C Sun
Natural killer (NK) cells are innate lymphocytes that have features of adaptive immunity such as clonal expansion and generation of long-lived memory. Interleukin-12 (IL-12) signaling through its downstream transcription factor signal transducer and activator of transcription 4 (STAT4) is required for the generation of memory NK cells after expansion. We identify gene loci that are highly enriched for STAT4 binding using chromatin immunoprecipitation sequencing for STAT4 and the permissive histone mark H3K4me3 in activated NK cells...
December 8, 2017: Science Immunology
https://www.readbyqxmd.com/read/29222069/cooperativity-between-different-trna-modifications-and-their-modification-pathways
#7
REVIEW
Mikołaj Sokołowski, Roland Klassen, Alexander Bruch, Raffael Schaffrath, Sebastian Glatt
Ribonucleotide modifications perform a wide variety of roles in synthesis, turnover and functionality of tRNA molecules. The presence of particular chemical moieties can refine the internal interaction network within a tRNA molecule, influence its thermodynamic stability, contribute novel chemical properties and affect its decoding behavior during mRNA translation. As the lack of specific modifications in the anticodon stem and loop causes disrupted proteome homeostasis, diminished response to stress conditions, and the onset of human diseases, the underlying modification cascades have recently gained particular scientific and clinical interest...
December 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29221919/impact-of-lifestyle-interventions-targeting-healthy-diet-physical-activity-and-weight-loss-on-asthma-in-adults-what-is-the-evidence
#8
Sharmilee M Nyenhuis, Anne E Dixon, Jun Ma
Unhealthy lifestyle factors such as poor diet quality, sedentary lifestyle, and obesity are associated with negative health consequences in asthma including poor asthma control, impaired quality of life, and greater health care utilization. Lifestyle modification is the cornerstone of behavioral treatments and has been effective in chronic diseases such as atherothrombotic vascular disease and diabetes. There is a critical need for lifestyle interventions in asthma care that address obesity and its intimately linked risk behaviors in terms of poor diet and physical inactivity...
December 5, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29217409/proteasome-phosphorylation-regulates-cocaine-induced-sensitization
#9
Frankie R Gonzales, Kristin K Howell, Lara E Dozier, Stephan G Anagnostaras, Gentry N Patrick
Repeated exposure to cocaine produces structural and functional modifications at synapses from neurons in several brain regions including the nucleus accumbens. These changes are thought to underlie cocaine-induced sensitization. The ubiquitin proteasome system plays a crucial role in the remodeling of synapses and has recently been implicated in addiction-related behavior. The ATPase Rpt6 subunit of the 26S proteasome is phosphorylated by Ca2+/calmodulin-dependent protein kinases II alpha at ser120 which is thought to regulate proteasome activity and distribution in neurons...
December 4, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29214844/barriers-to-quitting-smoking-among-young-adults-the-role-of-socioeconomic-status
#10
Samantha Carlson, Rachel Widome, Lindsey Fabian, Xianghua Luo, Jean Forster
PURPOSE: The aims of this analysis were to explore how self-reported barriers to quitting vary by socioeconomic status (SES) among young-adult smokers and to assess their relationship to quitting. DESIGN: This analysis uses 2 waves of telephone-survey data from the Minnesota Adolescent Community Cohort study. SETTING: Midwestern United States. PARTICIPANTS: Participants (n = 419) were smokers aged 17 to 24 years. MEASURES: Socioeconomic status was estimated using the highest level of education completed by the participants' parents...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29214239/protonation-enhances-the-inherent-helix-forming-propensity-of-phlip
#11
Chitrak Gupta, Blake Mertz
Cell-penetrating peptides (CPPs) can be potentially used in targeted delivery of therapeutic cargoes. However, their conformation in solution is poorly understood. We employed molecular dynamics simulations to probe the structural fluctuations of an anionic CPP, pH Low Insertion Peptide (pHLIP), in solution to determine the effects of modifications to selected residues on the structure of pHLIP. Two types of modifications were tested: (1) protonation of aspartic acid residues and (2) point mutations known to affect the acid sensitivity of pHLIP...
November 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/29214139/the-effects-of-advance-notice-on-problem-behavior-occasioned-by-interruptions-of-an-ongoing-activity-in-a-young-girl-with-autism
#12
Stephanie Vasquez, Adam Brewer, Yanerys Leon, Janet Vasquez
The current study describes a trial-based functional analysis of problem behavior conducted in a home setting for a 7-year-old girl with autism. Problem behavior was occasioned by interruptions to an ongoing activity. Advance notice, in the form of a 2-min warning, and the sound of a timer were used to signal termination of a current activity and were effective at reducing problem behavior along with increasing compliance to the interruptive demands. A trial-based functional analysis, which are not common in the applied literature, was conducted in a home setting for young girl with autism, using antecedent and consequence modifications described by Hagopian, Bruzek, Bowman, and Jennett (2007), identified the variables that occasioned and maintained problem behavior were interruptions to an ongoing activity followed by regaining uninterrupted access to the previous activity...
December 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/29213229/reflex-modification-audiometry-reveals-dual-roles-for-olivocochlear-neurotransmission
#13
Paul D Allen, Anne E Luebke
Approximately 15% of American adults report some degree of difficulty hearing in a noisy environment or have auditory filtering difficulties. There are objective clinical tests of auditory filtering, yet few tests exist for mouse models that do not rely on extensive training. We have used reflex modification audiometry (RMA) and developed exclusion criteria for the mouse model. This RMA based test makes use of the acoustic startle response (ASR) and the ability of prepulses to inhibit the ASR [i.e., prepulse inhibition (PPI)] to assess the mouse's ability to detect prepulse signals presented in quiet or embedded in masking noise...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29212351/the-multi-faceted-impact-of-peroxiredoxins-on-aging-and-disease
#14
Svetlana N Radyuk, William C Orr
<i>Significance:</i> Peroxiredoxins, a family of thiol-associated peroxidases, are purported to play a major role in sensing and managing H2O2 concentrations and transducing peroxide-derived signals. <i>Recent advances:</i> Peroxiredoxins can act as detoxifying factors and impart effects to cells that can be either sparing or suicidal. Advances have been made to address the qualitative changes in peroxiredoxin function in response to quantitative changes in the signal level and to understand how peroxidredoxin activity could be affected by their own substrates...
December 6, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29210386/platinum-for-hydrogen-sensing-surface-and-grain-boundary-scattering-antagonistic-effects-in-pt-au-core-shell-nanoparticle-assemblies-prepared-using-a-langmuir-blodgett-method
#15
K Rajouâ, L Baklouti, F Favier
Hydrogen resistive sensors are fabricated through the synthesis of a series of Pt@Au core-shell nanoparticles showing various Pt shell thicknesses. Resulting colloids are assembled as hexagonal close-packed 2D monolayers of various dimension characteristics using a simple Langmuir-Blodgett method. The fabricated sensors show attractive hydrogen sensing performances with reversible responses in extended sensing ranges, a good specificity towards H2, short response and recovery times… Sensing measurements and data analyses allow the demonstration of the associated sensing mechanisms...
December 6, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29208680/subtle-modifications-to-oxytocin-produce-ligands-that-retain-potency-and-improved-selectivity-across-species
#16
Markus Muttenthaler, Åsa Andersson, Irina Vetter, Rohit Menon, Marta Busnelli, Lotten Ragnarsson, Christian Bergmayr, Sarah Arrowsmith, Jennifer R Deuis, Han Sheng Chiu, Nathan J Palpant, Margaret O'Brien, Terry J Smith, Susan Wray, Inga D Neumann, Christian W Gruber, Richard J Lewis, Paul F Alewood
Oxytocin and vasopressin mediate various physiological functions that are important for osmoregulation, reproduction, cardiovascular function, social behavior, memory, and learning through four G protein-coupled receptors that are also implicated in high-profile disorders. Targeting these receptors is challenging because of the difficulty in obtaining ligands that retain selectivity across rodents and humans for translational studies. We identified a selective and more stable oxytocin receptor (OTR) agonist by subtly modifying the pharmacophore framework of human oxytocin and vasopressin...
December 5, 2017: Science Signaling
https://www.readbyqxmd.com/read/29205175/anomalous-water-dynamics-at-surfaces-and-interfaces-synergistic-effects-of-confinement-and-surface-interactions
#17
Rajib Biswas, Biman Bagchi
In nature, water is often found in contact with surfaces that are extended on the scale of molecule size but small on a macroscopic scale. Examples include lipid bilayers and reverse micelles as well as biomolecules like proteins, DNA and zeolites, to name a few. While the presence of surfaces and interfaces interrupts the continuous hydrogen bond network of liquid water, confinement on a mesoscopic scale introduces new features. Even when extended on a molecular scale, natural and biological surfaces often have features (like charge, hydrophobicity) that vary on the scale of the molecular diameter of water...
December 5, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29204711/voltage-sensitive-potassium-channels-of-the-bk-type-and-their-coding-genes-are-alcohol-targets-in-neurons
#18
Alex M Dopico, Anna N Bukiya, Jill C Bettinger
Among all members of the voltage-gated, TM6 ion channel superfamily, the proteins that constitute calcium- and voltage-gated potassium channels of large conductance (BK) and their coding genes are unique for their involvement in ethanol-induced disruption of normal physiology and behavior. Moreover, in vitro studies document that BK activity is modified by ethanol with an EC50~23 mM, which is near blood alcohol levels considered legal intoxication in most states of the USA (0.08 g/dL = 17.4 mM). Following a succinct introduction to our current understanding of BK structure and function in central neurons, with a focus on neural circuits that contribute to the neurobiology of alcohol use disorders (AUD), we review the modifications in organ physiology by alcohol exposure via BK and the different molecular elements that determine the ethanol response of BK in alcohol-naïve systems, including the role of an ethanol-recognizing site in the BK-forming slo1 protein, modulation of accessory BK subunits, and their coding genes...
December 5, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29203518/dna-methylation-in-epigenetic-inheritance-of-metabolic-diseases-through-the-male-germ-line
#19
Louise Rh Illum, Stine T Bak, Sten Lund, Anders Lade Nielsen
The global rise in metabolic diseases can be attributed to a complex interplay between biology, behavior and environmental factors. This article reviews the current literature concerning DNA methylation-based epigenetic inheritance (intergenerational and transgenerational) of metabolic diseases through the male germ line. Included are a presentation of the basic principles for DNA methylation in developmental programming, and a description of windows of susceptibility for the inheritance of environmentally induced aberrations in DNA methylation and their associated metabolic disease phenotypes...
December 4, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29203016/investigate-moped-car-conflicts-in-china-using-a-naturalistic-driving-study-approach
#20
Yi G Glaser, Feng Guo, Youjia Fang, Bing Deng, Jonathan Hankey
PROBLEM: Mopeds are a popular transportation mode in Europe and Asia. Moped-related traffic accidents account for a large proportion of crash fatalities. To develop moped-related crash countermeasures, it is important to understand the characteristics of moped-related conflicts. METHOD: Naturalistic driving study data were collected in Shanghai, China from 36 car drivers. The data included 2,878h and 78,296km driven from 13,149 trips. Moped-car conflicts were identified and examined from the passenger car driver's perspective using kinematic trigger algorithms and manual video reduction...
December 2017: Journal of Safety Research
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