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https://www.readbyqxmd.com/read/29909453/m-6-a-rna-methylation-controls-neural-development-and-is-involved-in-human-diseases
#1
REVIEW
Kunzhao Du, Longbin Zhang, Trevor Lee, Tao Sun
RNA modifications are involved in many aspects of biological functions. N6-methyladenosine (m6 A) is one of the most important forms of RNA methylation and plays a vital role in regulating gene expression, protein translation, cell behaviors, and physiological conditions in many species, including humans. The dynamic and reversible modification of m6 A is conducted by three elements: methyltransferases ("writers"), such as methyltransferase-like protein 3 (METTL3) and METTL14; m6 A-binding proteins ("readers"), such as the YTH domain family proteins (YTHDFs) and YTH domain-containing protein 1 (YTHDC1); and demethylases ("erasers"), such as fat mass and obesity-associated protein (FTO) and AlkB homolog 5 (ALKBH5)...
June 16, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29908975/differential-effect-of-hydroxyapatite-nano-particle-versus-nano-rod-decorated-titanium-micro-surface-on-osseointegration
#2
Long Bai, Yanlian Liu, Zhibin Du, Zeming Weng, Wei Yao, Xiangyu Zhang, Xiaobo Huang, Xiaohong Yao, Ross Crawford, Ruiqiang Hang, Di Huang, Bin Tang, Yin Xiao
Coating materials applied for intraosseous implants must be optimized to stimulate osseointegration. Osseointegration is a temporal and spatial physiological process that not only requires interactions between osteogenesis and angiogenesis but also necessitates a favorable immune microenvironment. It is now well-documented that hierarchical nano-micro surface structures promote the long-term stability of implants, the interactions between nano-micro structure and the immune response are largely unknown. Here, we report the effects of microporous titanium (Ti) surfaces coated with nano-hydroxyapatite (HA) produced by micro-arc oxidation and steam-hydrothermal treatment (SHT) on multiple cell behavior and osseointegration...
June 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29908771/cognitive-behavioral-therapy-improves-weight-loss-and-quality-of-life-in-women-with-polycystic-ovary-syndrome-a-pilot-randomized-clinical-trial
#3
Laura G Cooney, Lauren W Milman, Liisa Hantsoo, Sara Kornfield, Mary D Sammel, Kelly C Allison, C Neill Epperson, Anuja Dokras
OBJECTIVE: To compare the effects of cognitive-behavioral therapy (CBT) and lifestyle modification (LS) versus LS alone on weight, depressive and anxiety symptoms, and stress response in women with polycystic ovary syndrome (PCOS), overweight/obesity, and depressive symptoms. DESIGN: A 16-week pilot randomized clinical trial. SETTING: Tertiary-care PCOS center. PATIENT(S): Overweight/obese women with PCOS and depressive symptoms...
June 13, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29908306/listeria-monocytogenes-and-salmonella-enterica-affect-the-expression-of-nisin-gene-and-its-production-by-lactococcus-lactis
#4
Soosan Abdollahi, Mohammad Hossein Ghahremani, Neda Setayesh, Nasrin Samadi
The Lactococcus lactis is known as a probiotic bacterium and also as a producer of nisin. Nisin has been approved by related legal agencies to be used as an antimicrobial peptide in food preservation. In fact, the L. lactis is present in different food products along with other micro-organisms especially pathogenic bacteria. So, it is important to predict the behavior of nisin-producer strain in contact with other pathogens. In this regard, nisin gene expression and the level of secreted biologically active form of nisin by L...
June 13, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29908287/characterization-of-nanomedicines-surface-coverage-using-molecular-probes-and-capillary-electrophoresis
#5
J-B Coty, F Varenne, A Benmalek, O Garsaa, I Le Potier, M Taverna, C Smadja, C Vauthier
A faithful characterization of nanomedicine (NM) is needed for a better understanding of their in vivo outcomes. Size and surface charge are studied with well-established methods. However, other relevant parameters for the understanding of NM behavior in vivo remain largely inaccessible. For instance, the reactive surface of nanomedicines, which are often grafted with macromolecules to decrease their recognition by the immune system, is excluded from a systematic characterization. Yet, it is known that a subtle modification of NM's surface characteristics (grafting density, molecular architecture and conformation of macromolecules) is at the root of major changes in the presence of biological components...
June 13, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29908060/information-cost-memory-length-and-market-instability
#6
Cees Diks, Xindan Li, Chengyao Wu
In this article, we study the instability of a stock market with a modified version of Diks and Dindo's (2008) model where the market is characterized by nonlinear interactions between informed traders and uninformed traders. In the interaction of heterogeneous agents, we replace the replicator dynamics for the fractions by logistic strategy switching. This modification makes the model more suitable for describing realistic price dynamics, as well as more robust with respect to parameter changes. One goal of our paper is to use this model to explore if the arrival of new information (news) and investor behavior have an effect on market instability...
July 2018: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/29907738/epigenetic-regulation-of-the-oxytocin-receptor-is-associated-with-neural-response-during-selective-social-attention
#7
Meghan H Puglia, Jessica J Connelly, James P Morris
Aberrant attentional biases to social stimuli have been implicated in a number of disorders including autism and social anxiety disorder. Oxytocin, a naturally-occurring mammalian hormone and neuromodulator involved in regulating social behavior, has been proposed to impact basic biological systems that facilitate the detection of and orientation to social information. Here, we investigate a role for naturally-occurring variability in the endogenous oxytocinergic system in regulating neural response during attention to social information...
June 15, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29907046/high-density-liquid-structure-enhancement-in-glass-forming-aqueous-solution-of-licl
#8
G Camisasca, M De Marzio, M Rovere, P Gallo
We investigate using molecular dynamics simulations the dynamical and structural properties of LiCl:6H2 O aqueous solution upon supercooling. This ionic solution is a glass forming liquid of relevant interest in connection with the study of the anomalies of supercooled water. The LiCl:6H2 O solution is easily supercooled and the liquid state can be maintained over a large decreasing temperature range. We performed simulations from ambient to 200 K in order to investigate how the presence of the salt modifies the behavior of supercooled water...
June 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29906092/nanoscale-control-of-oxygen-defects-and-metal-insulator-transition-in-epitaxial-vanadium-dioxides
#9
Yogesh Sharma, Janakiraman Balachandran, Changhee Sohn, Jaron T Krogel, Panchapakesan Ganesh, Liam Collins, Anton V Ievlev, Qian Li, Xiang Gao, Nina Balke, Olga S Ovchinnikova, Sergei V Kalinin, Olle Heinonen, Ho Nyung Lee
Strongly correlated vanadium dioxide (VO2) is one of the most promising materials to exhibit temperature-driven, metal-insulator transition (MIT) near room temperature. The ability to manipulate the MIT at nanoscale offers both an insight to understand the energetics of phase transition and a promising potential for nanoelectronic devices. In this work, we study nanoscale electrical modifications of the MIT in epitaxial VO2 thin films using a combined approach with scanning probe microscopy (SPM) and theoretical calculations...
June 15, 2018: ACS Nano
https://www.readbyqxmd.com/read/29905972/feeling-the-force-how-pollen-tubes-deal-with-obstacles
#10
Jan T Burri, Hannes Vogler, Nino F Läubli, Chengzhi Hu, Ueli Grossniklaus, Bradley J Nelson
Physical forces are involved in the regulation of plant development and morphogenesis by translating mechanical stress into the modification of physiological processes, which, in turn, can affect cellular growth. Pollen tubes respond rapidly to external stimuli and provide an ideal system to study the effect of mechanical cues at the single-cell level. Here, pollen tubes were exposed to mechanical stress while monitoring the reconfiguration of their growth and recording the generated forces in real-time. We combined a lab-on-a-chip device with a microelectromechanical systems (MEMS)-based capacitive force sensor to mimic and quantify the forces that are involved in pollen tube navigation upon confronting mechanical obstacles...
June 15, 2018: New Phytologist
https://www.readbyqxmd.com/read/29904329/an-exploratory-study-of-selfitis-and-the-development-of-the-selfitis-behavior-scale
#11
Janarthanan Balakrishnan, Mark D Griffiths
In 2014, stories appeared in national and international media claiming that the condition of "selfitis" (the obsessive taking of selfies) was to be classed as a mental disorder by the American Psychiatric Association and that the condition could be borderline, acute, or chronic. However, the stories were a hoax but this did not stop empirical research being carried out into the concept. The present study empirically explored the concept and collected data on the existence of selfitis with respect to the three alleged levels (borderline, acute, and chronic) and developed the Selfitis Behavior Scale (SBS)...
2018: International Journal of Mental Health and Addiction
https://www.readbyqxmd.com/read/29904025/stabilization-of-loess-using-nano-sio%C3%A2
#12
Ran Kong, Fanyu Zhang, Gonghui Wang, Jianbing Peng
Improving the performance of loess is of significant importance for lowering its collapsibility and water sensitivity to construction requirements and for geohazard mitigation. The present paper studies the changes in mechanical, structural, and mineralogical properties of nano-SiO₂-treated loess with different contents and curing days. The mechanical behavior was examined by unconfined compressive strength (UCS) of untreated and treated loess. To better understand the mechanisms of stabilization, particle size distributions, scanning electron microscope (SEM) images, and X-ray diffraction (XRD) analyses were carried out...
June 14, 2018: Materials
https://www.readbyqxmd.com/read/29903996/applications-of-nanomaterials-based-on-magnetite-and-mesoporous-silica-on-the-selective-detection-of-zinc-ion-in-live-cell-imaging
#13
Roghayeh Sadeghi Erami, Karina Ovejero, Soraia Meghdadi, Marco Filice, Mehdi Amirnasr, Antonio Rodríguez-Diéguez, María Ulagares De La Orden, Santiago Gómez-Ruiz
Functionalized magnetite nanoparticles (FMNPs) and functionalized mesoporous silica nanoparticles (FMSNs) were synthesized by the conjugation of magnetite and mesoporous silica with the small and fluorogenic benzothiazole ligand, that is, 2(2-hydroxyphenyl)benzothiazole ( hpbtz ). The synthesized fluorescent nanoparticles were characterized by FTIR, XRD, XRF, 13 C CP MAS NMR, BET, and TEM. The photophysical behavior of FMNPs and FMSNs in ethanol was studied using fluorescence spectroscopy. The modification of magnetite and silica scaffolds with the highly fluorescent benzothiazole ligand enabled the nanoparticles to be used as selective and sensitive optical probes for zinc ion detection...
June 14, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29902642/diagnosis-and-treatment-of-rumination-syndrome
#14
Magnus Halland, John Pandolfino, Elizabeth Barba
Rumination syndrome is a functional gastrointestinal disorder characterized by effortless post-prandial regurgitation. The disorder appears uncommon, although only limited epidemiological data are available. Awareness of the characteristic symptoms is essential for recognizing the disorder, and thus avoiding the long delay in diagnosis which many patients experience. Whilst objective testing by post-prandial esophageal high resolution impedance manometry is available in select referral centers, a clinical diagnosis can be made in most patients...
June 11, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29902282/lack-of-complex-type-n-glycans-lessens-aberrant-neuronal-properties
#15
M Kristen Hall, Douglas A Weidner, Austin A Whitman, Ruth A Schwalbe
Modifications in surface glycans attached to proteins via N-acetylglucosamine-β1-N-asparagine linkage have been linked to tumor development and progression. These modifications include complex N-glycans with high levels of branching, fucose and sialic acid residues. Previously, we silenced Mgat2 in neuroblastoma (NB) cells, which halted the conversion of hybrid type N-glycans to complex type, to generate a novel cell line, NB_1(-Mgat2). By comparing the aberrant cell properties of the NB_1(-Mgat2) cell line to the parental cell line (NB_1), we investigated the impact of eliminating complex type N-glycans on NB cell behavior...
2018: PloS One
https://www.readbyqxmd.com/read/29899666/epigenetic-mechanisms-of-alcohol-neuroadaptation-insights-from-drosophila
#16
REVIEW
Maria E Ramirez-Roman, Carlos E Billini, Alfredo Ghezzi
Alcohol addiction is a serious condition perpetuated by enduring physiological and behavioral adaptations. An important component of these adaptations is the long-term rearrangement of neuronal gene expression in the brain of the addicted individual. Epigenetic histone modifications have recently surfaced as important modulators of the transcriptional adaptation to alcohol as these are thought to represent a form of transcriptional memory that is directly imprinted on the chromosome. Some histone modifications affect transcription by modulating the accessibility of the underlying DNA, whereas others have been proposed to serve as marks read by transcription factors as a "histone code" that helps to specify the expression level of a gene...
2018: Journal of Experimental Neuroscience
https://www.readbyqxmd.com/read/29898692/the-implementation-and-adherence-to-evidence-based-protocols-for-psychotherapy-for-depression-the-perspective-of-therapists-in-dutch-specialized-mental-healthcare
#17
Sanne J E Bruijniks, Gerdien Franx, Marcus J H Huibers
BACKGROUND: Although psychotherapy is an effective treatment for depression, a large number of patients still do not receive care according to the protocols that are used in clinical trials. Instead, patients often receive a modified version of the original intervention. It is not clear how and when treatment protocols are used or modified in the Dutch specialized mental health care and whether these changes lead to suboptimal adherence to treatment protocols. METHODS: In the context of an ongoing multicenter trial that investigates whether twice-weekly sessions of protocolized interpersonal psychotherapy (IPT) and cognitive behavioral therapy (CBT) for depression lead to better treatment outcomes compared to once-weekly sessions, two focus groups using semi-structured interviews were organized...
June 14, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29895814/changes-associated-with-improved-outcomes-for-cats-entering-rspca-queensland-shelters-from-2011-to-2016
#18
Caroline Audrey Kerr, Jacquie Rand, John Murray Morton, Ronelle Reid, Mandy Paterson
This retrospective study of cat admissions to RSPCA Queensland shelters describes changes associated with improved outcomes ending in live release in 2016 compared to 2011. There were 13,911 cat admissions in 2011 and 13,220 in 2016, with approximately 50% in both years admitted as strays from the general public or council contracts. In contrast, owner surrenders halved from 30% to 15% of admissions. Percentages of admissions ending in euthanasia decreased from 58% to 15%. Only 5% of cat admissions were reclaimed in each of these years, but the percentage rehomed increased from 34% to 74%, of which 61% of the increase was contributed by in-shelter adoptions and 39% from non-shelter sites, predominately retail partnerships...
June 12, 2018: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29894973/simultaneous-functionalization-and-magnetization-of-biochar-via-nh-3-ambiance-pyrolysis-for-efficient-removal-of-cr-vi
#19
Md Manik Mian, Guijian Liu, Balal Yousaf, Biao Fu, Habib Ullah, Muhammad Ubaid Ali, Qumber Abbas, Mehr Ahmed Mujtaba Munir, Liu Ruijia
Enhancing biochar adsorption capabilities and recollection ability is essential for efficient biochar application. In this study, Nitrogen-doped magnetic biochar was prepared via one-step heating of FeCl3 -laden agar biomass under NH3 environment. Synthesized magnetic biochar ABF-N800 shows a maximum Cr (VI) adsorption capacity up to 142.86 mg g-1 , outperforming that of magnetic biochar and many other previously reported materials. Moreover, a significant increase of magnetic properties obtained by NH3 ambiance pyrolysis enables easy separation of the adsorbent from the solution after treated with Cr (VI)...
June 6, 2018: Chemosphere
https://www.readbyqxmd.com/read/29893856/biallelic-missense-variants-in-zbtb11-can-cause-intellectual-disability-in-human
#20
Zohreh Fattahi, Taimoor I Sheikh, Luciana Musante, Memoona Rasheed, Ibrahim Ihsan Taskiran, Ricardo Harripaul, Hao Hu, Somayeh Kazeminasab, Muhammad Rizwan Alam, Masoumeh Hosseini, Farzaneh Larti, Zhila Ghaderi, Arzu Celik, Muhammad Ayub, Muhammad Ansar, Mohammad Haddadi, Thomas F Wienker, Hans Hilger Ropers, Kimia Kahrizi, John B Vincent, H Najmabadi
Exploring genes and pathways underlying Intellectual Disability (ID) provides insight into brain development and function, clarifying the complex puzzle of how cognition develops. As part of ongoing systematic studies to identify candidate ID genes, linkage analysis and next generation sequencing revealed ZBTB11, as a novel candidate ID gene. ZBTB11 encodes a less-studied transcription regulator and the two identified missense variants in this study may disrupt canonical Zn2+-binding residues of its C2H2 zinc finger domain, leading to possible altered DNA binding...
June 8, 2018: Human Molecular Genetics
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