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Bryce Andrew Allio, Andrew Charles Peterson
The clinical presentation of the neurogenic bladder can be as vast as the pathologic causes however urodynamics (UDS) can help guide clinical decision-making and help simplify a complex disease state. UDS may be considered as the gold standard in helping to break down complex and multifactorial voiding dysfunction into manageable goals; these include protecting the upper tracts, limiting urinary tract infections (UTI) via avoiding urinary stasis, and maintaining quality of life. Included within are examples of normal to pathologic tracings including normal filling and voiding, detrusor sphincteric coordination, changes in compliance, etc...
February 2016: Translational Andrology and Urology
Matthia A Karreman, Luc Mercier, Nicole L Schieber, Gergely Solecki, Guillaume Allio, Frank Winkler, Bernhard Ruthensteiner, Jacky G Goetz, Yannick Schwab
Intravital microscopy provides dynamic understanding of multiple cell biological processes, but its limited resolution has so far precluded structural analysis. Because it is difficult to capture rare and transient events, only a few attempts have been made to observe specific developmental and pathological processes in animal models using electron microscopy. The multimodal correlative approach that we propose here combines intravital microscopy, microscopic X-ray computed tomography and three-dimensional electron microscopy...
January 15, 2016: Journal of Cell Science
Marta Tello, Caroline Spenlé, Joseph Hemmerlé, Luc Mercier, Roxane Fabre, Guillaume Allio, Patricia Simon-Assmann, Jacky G Goetz
Mechanical interaction between cells and their surrounding extracellular matrix (ECM) controls key processes such as proliferation, differentiation and motility. For many years, two-dimensional (2D) models were used to better understand the interactions between cells and their surrounding ECM. More recently, variation of the mechanical properties of tissues has been reported to play a major role in physiological and pathological scenarios such as cancer progression. The 3D architecture of the ECM finely tunes cellular behavior to perform physiologically relevant tasks...
February 1, 2016: Methods: a Companion to Methods in Enzymology
Arianna Allio, Chiara Calorio, Claudio Franchino, Daniela Gavello, Emilio Carbone, Andrea Marcantoni
ETHNOPHARMACOLOGICAL RELEVANCE: Tilia tomentosa Moench bud extracts (TTBEs) is used in traditional medicine for centuries as sedative compound. Different plants belonging to the Tilia genus have shown their efficacy in the treatment of anxiety but still little is known about the mechanism of action of their bud extracts. AIM OF THE STUDY: To evaluate the action of TTBEs as anxiolytic and sedative compound on in vitro hippocampal neurons. MATERIAL AND METHODS: The anxiolytic effect of TTBEs was assayed by testing the effects of these compounds on GABAA receptor-activated chloride current of hippocampal neurons by means of the patch-clamp technique and microelectrode-arrays (MEAs)...
August 22, 2015: Journal of Ethnopharmacology
David H F Vandael, Matteo M Ottaviani, Christian Legros, Claudie Lefort, Nathalie C Guérineau, Arianna Allio, Valentina Carabelli, Emilio Carbone
KEY POINTS: Mouse chromaffin cells (MCCs) of the adrenal medulla possess fast-inactivating Nav channels whose availability alters spontaneous action potential firing patterns and the Ca(2+)-dependent secretion of catecholamines. Here, we report MCCs expressing large densities of neuronal fast-inactivating Nav1.3 and Nav1.7 channels that carry little or no subthreshold pacemaker currents and can be slowly inactivated by 50% upon slight membrane depolarization. Reducing Nav1.3/Nav1.7 availability by tetrodotoxin or by sustained depolarization near rest leads to a switch from tonic to burst-firing patterns that give rise to elevated Ca(2+)-influx and increased catecholamine release...
February 15, 2015: Journal of Physiology
Mery Malandrino, Agnese Giacomino, Ornella Abollino, Arianna Allio, Rosanna Toniolo, Maria Laura Colombo
Glyceric Macerates (GMs) and Mother Tinctures (MTs) are liquid preparations obtained from plant buds (for GMs) and flowers, leaves or roots (for MT) by extraction with a mixture of solvents. Their quality depends on the quality of the plant materials and on the preparation procedures. In this work we determined the concentrations of major, minor and trace elements in buds, flowers and other plant components and in the GMs and MTs obtained from them by Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) after microwave mineralization...
March 15, 2015: Journal of Pharmaceutical and Biomedical Analysis
Julien Armijo, Raphaël Allio, Cristian Mejía-Cortés
We demonstrate a method to experimentally calibrate the refractive index modulation in photorefractive lattices, a task rarely addressed that is crucial for quantitative comparisons of theories with experiments. We consider the linear propagation of a normally incident plane wave through simple lattices and its modulation amplitude at crystal output face. Finding no evidence of longitudinal (Talbot-like) oscillations, we discard an ideal propagation theory and construct a simple effective model that includes longitudinal relaxation...
August 25, 2014: Optics Express
Karl R J Link, Ileana Allio, Jacqueline S Rand, Elisabeth Eppler
Like in humans, diabetes mellitus is on the rise in cats. Feline diabetes is a suitable model for human type-2 diabetes. We investigated magnitude and timing of insulin suppression with induced hyperglycaemia and its relationship to plasma and urinary ketones and to pancreatic islet insulin. IGF-I is under discussion as a protective mechanism but little is known about its role in diabetes in general and its distinct localisation in feline pancreatic islets in particular. Thirteen healthy, adult cats were allocated to 2 groups and infused with glucose to maintain their blood glucose at a high or moderate concentration for 42 days resulting in insulin secretion suppression...
July 1, 2013: General and Comparative Endocrinology
R Allio
No abstract text is available yet for this article.
2002: Studi Piemontesi
Woojin Han, Bryce A Allio, David G Foster, Michael R King
Recently, a flow-based selectin-dependent method for the capture and enrichment of specific types of cells (CD34+ hematopoetic stem and progenitor cells and human leukemia HL60) from peripheral blood was demonstrated. However, these devices depend on a monolayer of selectin protein, which has been shown to have a maximum binding efficiency as a function of surface area. A novel surface coating of colloidal silica nanoparticles was designed that alters the surface roughness resulting in increased surface area...
January 26, 2010: ACS Nano
Sadeq Haouzir, Xavier Lemoine, Marie Desbordes, Mathieu Follet, Claire Meunier, Zohra Baarir, Gabrielle Allio, Jean-François Menard, Laurence Briant, Freddy Jouen, Michel Petit
Catatonia is a common but under-diagnosed neuropsychiatric syndrome characterized by the occurrence in a single patient of concomitant affective, motor and behavioral symptoms with a hazardous outcome (called lethal catatonia: LC). Deaths by thromboembolic disease have been previously reported in LC. A 2-year prospective study was carried out to examine D-dimer levels, an early and sensitive coagulation marker, in patients with catatonic disorders. Twenty-five acute catatonic patients and 50 psychiatric control patients - matched on age, gender, psychiatric diagnosis, general psychopathology and neuroleptic medication matched - were investigated and considered in relation to D-dimer blood levels and other biological variables (serum iron, creatine phosphokinase, leukocytosis)...
June 30, 2009: Psychiatry Research
Solenn Legallic, Jacqueline Bou, Sadeq Haouzir, Gabrielle Allio, Caroline Demily, Michel Petit, Thierry Frebourg, Florence Thibaut, Dominique Campion
A translocation disrupting the DISC 1 gene segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Mutation screening of this gene by routine PCR-based methods has remained largely negative. We sought to detect rearrangements affecting DISC 1 in 347 individuals meeting the DSM3R criteria for schizophrenia or schizoaffective disorder, 70 subjects with bipolar disorder and 377 psychiatrically healthy controls, but failed to detect any pathological rearrangement.
January 5, 2009: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Stéphanie Caharel, Christian Bernard, Florence Thibaut, Sadec Haouzir, Carole Di Maggio-Clozel, Gabrielle Allio, Gaël Fouldrin, Michel Petit, Robert Lalonde, Mohamed Rebaï
BACKGROUND: The main objective of the study was to determine whether patients with schizophrenia are deficient relative to controls in the processing of faces at different levels of familiarity and types of emotion and the stage where such differences may occur. METHODS: ERPs based on 18 patients with schizophrenia and 18 controls were compared in a face identification task at three levels of familiarity (unknown, familiar, subject's own) and for three types of emotion (disgust, smiling, neutral)...
September 2007: Schizophrenia Research
Céline Allio, Bernd Harbrecht
The crystal structure, phase relations and some physical properties of the binary zinc-rich phase RuZn3 are reported. The title compound is accessible via high-temperature reaction from the elements in the appropriate substance amount ratio. Its crystal structure was determined from a Rietveld profile fit to an X-ray diffractogram of pristine RuZn3 and confirmed by single-crystal X-ray structure analysis. The title compound adopts a tetragonal Al3Zr-type structure corresponding to an A2B2 anti-phase domain structure of the cubic AuCu3-type: a=376...
December 7, 2006: Dalton Transactions: An International Journal of Inorganic Chemistry
Lorenzo Allio, Bruce Ballantine, Richard Meads
Used well, science provides effective ways of identifying potential risks, protecting citizens, and using resources wisely. It enables government decisions to be based on evidence and provides a foundation for a rule-based framework that supports global trade. To ensure that the best available science becomes a key input in the decisions made by EU institutions, this abridged version of a working paper produced for the European Policy Centre, a leading, independent think tank, considers how science is currently used in the policy and decision-making processes of the EU, what the limitations of scientific evidence are, and how a risk assessment process based on scientific 'good practices' can be advantageous...
February 2006: Regulatory Toxicology and Pharmacology: RTP
Sandrine Louchart-de la Chapelle, Daniel Levillain, Jean-François Ménard, Alexis Van der Elst, Gabrielle Allio, Sadeq Haouzir, Sonia Dollfus, Dominique Campion, Florence Thibaut
Abnormal sensory gating in schizophrenia has frequently been reported. The strength of central inhibitory pathways was measured using the P50 component of the auditory evoked potential in a conditioning-testing paradigm. The relationships between a relative decrease in P50 amplitude to repeated auditory stimuli and clinical symptoms remain controversial. Using the Positive and Negative Syndrome Scale, we studied the P50 auditory conditioning-testing paradigm in 81 schizophrenic subjects, categorized into subgroups with and without prominent negative symptoms, in comparison with 88 control subjects...
July 15, 2005: Psychiatry Research
Debra Krupke, Dieter Näf, Matthew Vincent, Theresa Allio, Igor Mikaelian, John Sundberg, Carol Bult, Janan Eppig
Mice have long been used as models for the study of human cancer. The National Cancer Institute has included among its research areas of extraordinary opportunity the development of new mouse genetic models of human cancer and the exploration of cancer imaging as a research tool. Because of the volume and interconnectedness of relevant data, the creation and maintenance of bioinformatics resources of mouse tumor biology is necessary to facilitate current and future cancer research. The Mouse Tumor Biology (MTB) Database provides electronic access to data generated through the study of spontaneous and induced tumors in genetically defined mice (inbred, hybrid, spontaneous and induced mutant, and genetically engineered strains of mice)...
March 2005: Experimental Lung Research
H Jacquet, C Demily, E Houy, B Hecketsweiler, J Bou, G Raux, J Lerond, G Allio, S Haouzir, A Tillaux, C Bellegou, G Fouldrin, P Delamillieure, J F Ménard, S Dollfus, T D'Amato, M Petit, F Thibaut, T Frébourg, D Campion
DNA sequence variations within the 22q11 DiGeorge chromosomal region are likely to confer susceptibility to psychotic disorders. In a previous report, we identified several heterozygous alterations, including a complete deletion, of the proline dehydrogenase (PRODH) gene, which were associated with moderate hyperprolinemia in a subset of DSM III schizophrenic patients. Our objective was (i) to determine whether hyperprolinemia is associated with increased susceptibility for any of three psychiatric conditions (schizophrenia, schizoaffective disorder and bipolar disorder) and (ii) to establish a correlation between hyperprolinemia and PRODH genotypes...
May 2005: Molecular Psychiatry
Yanping Zhang, Gabrielle White Wolf, Krishna Bhat, Aiwen Jin, Theresa Allio, William A Burkhart, Yue Xiong
The gene encoding p53 mediates a major tumor suppression pathway that is frequently altered in human cancers. p53 function is kept at a low level during normal cell growth and is activated in response to various cellular stresses. The MDM2 oncoprotein plays a key role in negatively regulating p53 activity by either direct repression of p53 transactivation activity in the nucleus or promotion of p53 degradation in the cytoplasm. DNA damage and oncogenic insults, the two best-characterized p53-dependent checkpoint pathways, both activate p53 through inhibition of MDM2...
December 2003: Molecular and Cellular Biology
E Houy, G Raux, F Thibaut, A Belmont, C Demily, G Allio, S Haouzir, G Fouldrin, M Petit, T Frebourg, D Campion
As suggested by several studies, abnormal sensory gating measured by the P50 paradigm could be an endophenotype predisposing to schizophrenia. In a previous work, we have shown a significant association between the presence of at least one -2 bp deletion located within exon 6 of the CHRNA7-like gene and the P50 abnormality in the general population. A recent study involved polymorphisms located in the core promoter region of the CHRNA7 gene as risk factors for the P50 inhibitory deficit. Screening for promoter variants in a large population of schizophrenic patients (n=111) and control subjects (85), for whom auditory-evoked potentials had been recorded did not allow us to replicate these results...
March 2004: Molecular Psychiatry
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