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https://www.readbyqxmd.com/read/28981721/large-variation-in-the-ratio-of-mitochondrial-to-nuclear-mutation-rate-across-animals-implications-for-genetic-diversity-and-the-use-of-mitochondrial-dna-as-a-molecular-marker
#1
Remi Allio, Stefano Donega, Nicolas Galtier, Benoit Nabholz
It is commonly assumed that mitochondrial DNA (mtDNA) evolves at a faster rate than nuclear DNA (nuDNA) in animals. This has contributed to the popularity of mtDNA as a molecular marker in evolutionary studies. Analyzing 121 multilocus data sets and four phylogenomic data sets encompassing 4,676 species of animals, we demonstrate that the ratio of mitochondrial over nuclear mutation rate is highly variable among animal taxa. In nonvertebrates, such as insects and arachnids, the ratio of mtDNA over nuDNA mutation rate varies between 2 and 6, whereas it is above 20, on average, in vertebrates such as scaled reptiles and birds...
November 1, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28887470/direct-measurement-of-individual-phonon-lifetimes-in-the-clathrate-compound-ba7-81ge40-67au5-33
#2
Pierre-François Lory, Stéphane Pailhès, Valentina M Giordano, Holger Euchner, Hong Duong Nguyen, Reiner Ramlau, Horst Borrmann, Marcus Schmidt, Michael Baitinger, Matthias Ikeda, Petr Tomeš, Marek Mihalkovič, Céline Allio, Mark Robert Johnson, Helmut Schober, Yvan Sidis, Frédéric Bourdarot, Louis Pierre Regnault, Jacques Ollivier, Silke Paschen, Yuri Grin, Marc de Boissieu
Engineering lattice thermal conductivity requires to control the heat carried by atomic vibration waves, the phonons. The key parameter for quantifying it is the phonon lifetime, limiting the travelling distance, whose determination is however at the limits of instrumental capabilities. Here, we show the achievement of a direct quantitative measurement of phonon lifetimes in a single crystal of the clathrate Ba7.81Ge40.67Au5.33, renowned for its puzzling 'glass-like' thermal conductivity. Surprisingly, thermal transport is dominated by acoustic phonons with long lifetimes, travelling over distances of 10 to 100 nm as their wave-vector goes from 0...
September 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28605260/cellular-therapies-for-treatment-of-radiation-injury-report-from-a-nih-niaid-and-irsn-workshop
#3
Andrea L DiCarlo, Radia Tamarat, Carmen I Rios, Marc Benderitter, Christine W Czarniecki, Theresa C Allio, Francesca Macchiarini, Bert W Maidment, Jean-Rene Jourdain
In recent years, there has been increasing concern over the possibility of a radiological or nuclear incident occurring somewhere in the world. Intelligence agencies frequently report that terrorist groups and rogue nations are seeking to obtain radiological or nuclear weapons of mass destruction. In addition, there exists the real possibility that safety of nuclear power reactors could be compromised by natural (such as the tsunami and subsequent Fukushima accident in Japan in March, 2011) or accidental (Three Mile Island, 1979 and Chernobyl, 1986) events...
August 2017: Radiation Research
https://www.readbyqxmd.com/read/28408310/patient-satisfaction-regarding-outpatient-mastectomy-in-saint-nazaire-hospital-center
#4
M Simoni, F-X Laurent, S Evrard, L Bruneau, N Allio, M Randet
OBJECTIVES: To assess patient satisfaction with outpatient mastectomy and their postoperative quality of life. MATERIALS AND METHODS: A retrospective descriptive study was conducted of patients who had a mastectomy as outpatients at the hospital of Saint-Nazaire between January 2013 and May 2015. Patients were contacted by phone to answer a survey assessing their satisfaction. RESULTS: Out of 16 eligible patients for an outpatient mastectomy, 11 patients were included in our study (4 [25%] had to remain hospitalized after their intervention and one patient could not be contacted)...
February 22, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/26904410/urodynamic-and-physiologic-patterns-associated-with-the-common-causes-of-neurogenic-bladder-in-adults
#5
REVIEW
Bryce Andrew Allio, Andrew Charles Peterson
The clinical presentation of the neurogenic bladder can be as vast as the pathologic causes however urodynamics (UDS) can help guide clinical decision-making and help simplify a complex disease state. UDS may be considered as the gold standard in helping to break down complex and multifactorial voiding dysfunction into manageable goals; these include protecting the upper tracts, limiting urinary tract infections (UTI) via avoiding urinary stasis, and maintaining quality of life. Included within are examples of normal to pathologic tracings including normal filling and voiding, detrusor sphincteric coordination, changes in compliance, etc...
February 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/26659665/fast-and-precise-targeting-of-single-tumor-cells-in-vivo-by-multimodal-correlative-microscopy
#6
Matthia A Karreman, Luc Mercier, Nicole L Schieber, Gergely Solecki, Guillaume Allio, Frank Winkler, Bernhard Ruthensteiner, Jacky G Goetz, Yannick Schwab
Intravital microscopy provides dynamic understanding of multiple cell biological processes, but its limited resolution has so far precluded structural analysis. Because it is difficult to capture rare and transient events, only a few attempts have been made to observe specific developmental and pathological processes in animal models using electron microscopy. The multimodal correlative approach that we propose here combines intravital microscopy, microscopic X-ray computed tomography and three-dimensional electron microscopy...
January 15, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/26439175/generating-and-characterizing-the-mechanical-properties-of-cell-derived-matrices-using-atomic-force-microscopy
#7
Marta Tello, Caroline Spenlé, Joseph Hemmerlé, Luc Mercier, Roxane Fabre, Guillaume Allio, Patricia Simon-Assmann, Jacky G Goetz
Mechanical interaction between cells and their surrounding extracellular matrix (ECM) controls key processes such as proliferation, differentiation and motility. For many years, two-dimensional (2D) models were used to better understand the interactions between cells and their surrounding ECM. More recently, variation of the mechanical properties of tissues has been reported to play a major role in physiological and pathological scenarios such as cancer progression. The 3D architecture of the ECM finely tunes cellular behavior to perform physiologically relevant tasks...
February 1, 2016: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/26144285/bud-extracts-from-tilia-tomentosa-moench-inhibit-hippocampal-neuronal-firing-through-gabaa-and-benzodiazepine-receptors-activation
#8
Arianna Allio, Chiara Calorio, Claudio Franchino, Daniela Gavello, Emilio Carbone, Andrea Marcantoni
ETHNOPHARMACOLOGICAL RELEVANCE: Tilia tomentosa Moench bud extracts (TTBEs) is used in traditional medicine for centuries as sedative compound. Different plants belonging to the Tilia genus have shown their efficacy in the treatment of anxiety but still little is known about the mechanism of action of their bud extracts. AIM OF THE STUDY: To evaluate the action of TTBEs as anxiolytic and sedative compound on in vitro hippocampal neurons. MATERIAL AND METHODS: The anxiolytic effect of TTBEs was assayed by testing the effects of these compounds on GABAA receptor-activated chloride current of hippocampal neurons by means of the patch-clamp technique and microelectrode-arrays (MEAs)...
August 22, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/25620605/reduced-availability-of-voltage-gated-sodium-channels-by-depolarization-or-blockade-by-tetrodotoxin-boosts-burst-firing-and-catecholamine-release-in-mouse-chromaffin-cells
#9
David H F Vandael, Matteo M Ottaviani, Christian Legros, Claudie Lefort, Nathalie C Guérineau, Arianna Allio, Valentina Carabelli, Emilio Carbone
KEY POINTS: Mouse chromaffin cells (MCCs) of the adrenal medulla possess fast-inactivating Nav channels whose availability alters spontaneous action potential firing patterns and the Ca(2+)-dependent secretion of catecholamines. Here, we report MCCs expressing large densities of neuronal fast-inactivating Nav1.3 and Nav1.7 channels that carry little or no subthreshold pacemaker currents and can be slowly inactivated by 50% upon slight membrane depolarization. Reducing Nav1.3/Nav1.7 availability by tetrodotoxin or by sustained depolarization near rest leads to a switch from tonic to burst-firing patterns that give rise to elevated Ca(2+)-influx and increased catecholamine release...
February 15, 2015: Journal of Physiology
https://www.readbyqxmd.com/read/25554479/determination-of-major-minor-and-trace-elements-in-glyceric-macerates-and-mother-tinctures-and-in-the-starting-plant-materials
#10
Mery Malandrino, Agnese Giacomino, Ornella Abollino, Arianna Allio, Rosanna Toniolo, Maria Laura Colombo
Glyceric Macerates (GMs) and Mother Tinctures (MTs) are liquid preparations obtained from plant buds (for GMs) and flowers, leaves or roots (for MT) by extraction with a mixture of solvents. Their quality depends on the quality of the plant materials and on the preparation procedures. In this work we determined the concentrations of major, minor and trace elements in buds, flowers and other plant components and in the GMs and MTs obtained from them by Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) after microwave mineralization...
March 15, 2015: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/25321262/absolute-calibration-of-the-refractive-index-in-photo-induced-photonic-lattices
#11
Julien Armijo, Raphaël Allio, Cristian Mejía-Cortés
We demonstrate a method to experimentally calibrate the refractive index modulation in photorefractive lattices, a task rarely addressed that is crucial for quantitative comparisons of theories with experiments. We consider the linear propagation of a normally incident plane wave through simple lattices and its modulation amplitude at crystal output face. Finding no evidence of longitudinal (Talbot-like) oscillations, we discard an ideal propagation theory and construct a simple effective model that includes longitudinal relaxation...
August 25, 2014: Optics Express
https://www.readbyqxmd.com/read/23660449/the-effect-of-experimentally-induced-chronic-hyperglycaemia-on-serum-and-pancreatic-insulin-pancreatic-islet-igf-i-and-plasma-and-urinary-ketones-in-the-domestic-cat-felis-felis
#12
Karl R J Link, Ileana Allio, Jacqueline S Rand, Elisabeth Eppler
Like in humans, diabetes mellitus is on the rise in cats. Feline diabetes is a suitable model for human type-2 diabetes. We investigated magnitude and timing of insulin suppression with induced hyperglycaemia and its relationship to plasma and urinary ketones and to pancreatic islet insulin. IGF-I is under discussion as a protective mechanism but little is known about its role in diabetes in general and its distinct localisation in feline pancreatic islets in particular. Thirteen healthy, adult cats were allocated to 2 groups and infused with glucose to maintain their blood glucose at a high or moderate concentration for 42 days resulting in insulin secretion suppression...
July 1, 2013: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/20191702/-chocolate-makers-without-cocoa-notes-on-the-problems-of-the-confectionary-industry-in-turin-in-1946
#13
R Allio
No abstract text is available yet for this article.
2002: Studi Piemontesi
https://www.readbyqxmd.com/read/20017520/nanoparticle-coatings-for-enhanced-capture-of-flowing-cells-in-microtubes
#14
Woojin Han, Bryce A Allio, David G Foster, Michael R King
Recently, a flow-based selectin-dependent method for the capture and enrichment of specific types of cells (CD34+ hematopoetic stem and progenitor cells and human leukemia HL60) from peripheral blood was demonstrated. However, these devices depend on a monolayer of selectin protein, which has been shown to have a maximum binding efficiency as a function of surface area. A novel surface coating of colloidal silica nanoparticles was designed that alters the surface roughness resulting in increased surface area...
January 26, 2010: ACS Nano
https://www.readbyqxmd.com/read/19447502/the-role-of-coagulation-marker-fibrin-d-dimer-in-early-diagnosis-of-catatonia
#15
COMPARATIVE STUDY
Sadeq Haouzir, Xavier Lemoine, Marie Desbordes, Mathieu Follet, Claire Meunier, Zohra Baarir, Gabrielle Allio, Jean-François Menard, Laurence Briant, Freddy Jouen, Michel Petit
Catatonia is a common but under-diagnosed neuropsychiatric syndrome characterized by the occurrence in a single patient of concomitant affective, motor and behavioral symptoms with a hazardous outcome (called lethal catatonia: LC). Deaths by thromboembolic disease have been previously reported in LC. A 2-year prospective study was carried out to examine D-dimer levels, an early and sensitive coagulation marker, in patients with catatonic disorders. Twenty-five acute catatonic patients and 50 psychiatric control patients - matched on age, gender, psychiatric diagnosis, general psychopathology and neuroleptic medication matched - were investigated and considered in relation to D-dimer blood levels and other biological variables (serum iron, creatine phosphokinase, leukocytosis)...
June 30, 2009: Psychiatry Research
https://www.readbyqxmd.com/read/18395819/no-pathogenic-rearrangement-within-the-disc-1-gene-in-psychosis
#16
Solenn Legallic, Jacqueline Bou, Sadeq Haouzir, Gabrielle Allio, Caroline Demily, Michel Petit, Thierry Frebourg, Florence Thibaut, Dominique Campion
A translocation disrupting the DISC 1 gene segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Mutation screening of this gene by routine PCR-based methods has remained largely negative. We sought to detect rearrangements affecting DISC 1 in 347 individuals meeting the DSM3R criteria for schizophrenia or schizoaffective disorder, 70 subjects with bipolar disorder and 377 psychiatrically healthy controls, but failed to detect any pathological rearrangement.
January 5, 2009: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/17644314/the-effects-of-familiarity-and-emotional-expression-on-face-processing-examined-by-erps-in-patients-with-schizophrenia
#17
COMPARATIVE STUDY
Stéphanie Caharel, Christian Bernard, Florence Thibaut, Sadec Haouzir, Carole Di Maggio-Clozel, Gabrielle Allio, Gaël Fouldrin, Michel Petit, Robert Lalonde, Mohamed Rebaï
BACKGROUND: The main objective of the study was to determine whether patients with schizophrenia are deficient relative to controls in the processing of faces at different levels of familiarity and types of emotion and the stage where such differences may occur. METHODS: ERPs based on 18 patients with schizophrenia and 18 controls were compared in a face identification task at three levels of familiarity (unknown, familiar, subject's own) and for three types of emotion (disgust, smiling, neutral)...
September 2007: Schizophrenia Research
https://www.readbyqxmd.com/read/17102860/synthesis-crystal-structure-and-some-physical-properties-of-ruzn3
#18
Céline Allio, Bernd Harbrecht
The crystal structure, phase relations and some physical properties of the binary zinc-rich phase RuZn3 are reported. The title compound is accessible via high-temperature reaction from the elements in the appropriate substance amount ratio. Its crystal structure was determined from a Rietveld profile fit to an X-ray diffractogram of pristine RuZn3 and confirmed by single-crystal X-ray structure analysis. The title compound adopts a tetragonal Al3Zr-type structure corresponding to an A2B2 anti-phase domain structure of the cubic AuCu3-type: a=376...
December 7, 2006: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/16266777/enhancing-the-role-of-science-in-the-decision-making-of-the-european-union
#19
Lorenzo Allio, Bruce Ballantine, Richard Meads
Used well, science provides effective ways of identifying potential risks, protecting citizens, and using resources wisely. It enables government decisions to be based on evidence and provides a foundation for a rule-based framework that supports global trade. To ensure that the best available science becomes a key input in the decisions made by EU institutions, this abridged version of a working paper produced for the European Policy Centre, a leading, independent think tank, considers how science is currently used in the policy and decision-making processes of the EU, what the limitations of scientific evidence are, and how a risk assessment process based on scientific 'good practices' can be advantageous...
February 2006: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/16014313/p50-inhibitory-gating-deficit-is-correlated-with-the-negative-symptomatology-of-schizophrenia
#20
Sandrine Louchart-de la Chapelle, Daniel Levillain, Jean-François Ménard, Alexis Van der Elst, Gabrielle Allio, Sadeq Haouzir, Sonia Dollfus, Dominique Campion, Florence Thibaut
Abnormal sensory gating in schizophrenia has frequently been reported. The strength of central inhibitory pathways was measured using the P50 component of the auditory evoked potential in a conditioning-testing paradigm. The relationships between a relative decrease in P50 amplitude to repeated auditory stimuli and clinical symptoms remain controversial. Using the Positive and Negative Syndrome Scale, we studied the P50 auditory conditioning-testing paradigm in 81 schizophrenic subjects, categorized into subgroups with and without prominent negative symptoms, in comparison with 88 control subjects...
July 15, 2005: Psychiatry Research
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