Amelia M Stanton, Ryan L Boyd, Conall O'Cleirigh, Stephen Olivier, Brett Dolotina, Resign Gunda, Olivier Koole, Dickman Gareta, Tshwaraganang H Modise, Zahra Reynolds, Thandeka Khoza, Kobus Herbst, Thumbi Ndung'u, Willem A Hanekom, Emily B Wong, Deenan Pillay, Mark J Siedner
Health-related quality of life (HRQoL) assesses the perceived impact of health status across life domains. Although research has explored the relationship between specific conditions, including HIV, and HRQoL in low-resource settings, less attention has been paid to the association between multimorbidity and HRQoL. In a secondary analysis of cross-sectional data from the Vukuzazi ("Wake up and know ourselves" in isiZulu) study, which identified the prevalence and overlap of non-communicable and infectious diseases in the uMkhanyakunde district of KwaZulu-Natal, we (1) evaluated the impact of multimorbidity on HRQoL; (2) determined the relative associations among infectious diseases, non-communicable diseases (NCDs), and HRQoL; and (3) examined the effects of controlled versus non-controlled disease on HRQoL...
2024: PloS One