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https://www.readbyqxmd.com/read/27913795/prevalence-of-sti-symptoms-and-high-levels-of-stigma-in-sti-healthcare-among-men-who-have-sex-with-men-in-dar-es-salaam-tanzania-a-respondent-driven-sampling-study
#1
Michael W Ross, Markus Larsson, Joyce E Nyoni, Anette Agardh
Symptoms of sexually transmitted infections (STIs), whether they are presented for treatment or diagnosis, and how they are received by the clinician where they are presented, may be concomitants of stigma associated with homosexuality in homophobic climates. We analyzed respondent-driven sampling data from a study on 200 young men who have sex with men (MSM) in Dar es Salaam, Tanzania to examine sample prevalence, treatment and clinician response to 10 symptoms potentially associated with STIs. Survey measures included 10 self-reported STI symptoms, further specified according to location (genital, anal, oral), further specified according to place of diagnosis, place of, treatment whether there was pharmacy treatment or self-medication, healthcare worker (HCW) inquiries about source of infection and whether the HCW was polite...
December 2, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27906015/validation-of-a-self-reported-hiv-symptoms-list-the-iss-hiv-symptoms-scale
#2
Raffaella Bucciardini, Katherina Pugliese, Daniela Francisci, Andrea Costantini, Elisabetta Schiaroli, Miriam Cognigni, Chiara Tontini, Stefano Lucattini, Luca Fucili, Massimiliano Di Gregorio, Marco Mirra, Vincenzo Fragola, Sara Pompili, Rita Murri, Stefano Vella
BACKGROUND: To describe the development and the psychometric properties of the Istituto Superiore di Sanità-HIV symptoms scale (lSS-HIV symptoms scale). METHODS: The ISS-HIV symptom scale was developed by an Italian working team including researchers, physicians and people living with HIV. The development process went through the following steps: (1) review of HIV/AIDS literature; (2) focus group; (3) pre-test analysis; (4) scale validation. RESULTS: The 22 symptoms of HIV-ISS symptoms scale were clustered in five factors: pain/general discomfort (7 items); depression/anxiety (4 items); emotional reaction/psychological distress (5 items); gastrointestinal discomfort (4 items); sexual discomfort (2 items)...
April 9, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27836795/ultrasound%C3%A2-for%C3%A2-patients%C3%A2-in-a-high-hiv-tb-prevalence-setting-a%C3%A2-needs-assessment-and-review-of-focused-applications-for-sub-saharan-africa
#3
REVIEW
Tom Heller, Eric A Mtemang'ombe, Michaëla A M Huson, Charlotte C Heuvelings, Sabine Bélard, Saskia Janssen, Sam Phiri, Martin P Grobusch
Ultrasound is increasingly used in point-of-care applications and has great potential to support the diagnosis of infectious diseases, especially in resource-limited settings. We performed a cross-sectional study including 100 Malawian patients with a clinical indication for ultrasound and reviewed the literature on point-of-care ultrasound (POCUS) in Sub-Saharan Africa to establish its applicability, most frequent indications, findings, and implications for treatment, and therefore relevance in POCUS curricula, with a main focus on infectious diseases...
November 8, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27829064/acceptability-study-on-hiv-self-testing-among-transgender-women-men-who-have-sex-with-men-and-female-entertainment-workers-in-cambodia-a-qualitative-analysis
#4
Khuondyla Pal, Chanrith Ngin, Sovannary Tuot, Pheak Chhoun, Cheaty Ly, Srean Chhim, Minh-Anh Luong, Brent Tatomir, Siyan Yi
BACKGROUND: In Cambodia, HIV prevalence is high while HIV testing rates remain low among transgender women (TG women), men who have sex with men (MSM), and female entertainment workers (FEW). Introducing self-testing for HIV to these key populations (KPs) could potentially overcome the under-diagnosis of HIV and significantly increase testing rates and receipt of the results, and thus could decrease transmission. Therefore, this study aimed to determine the acceptability of HIV self-testing (HIVST) among these three categories of KPs...
2016: PloS One
https://www.readbyqxmd.com/read/27803833/coexistent-pseudogout-and-mycobacterium-avium-intracellulare-septic-arthritis-in-a-patient-with-hiv-and-esrd
#5
Wais Afzal, Omer M Wali, Kelly L Cervellione, Bhupinder B Singh, Farshad Bagheri
Pseudogout is a crystal-induced arthropathy characterized by the deposition of calcium pyrophosphate dihydrate (CPPD) crystals in synovial fluid, menisci, or articular cartilage. Although not very common, this entity can be seen in patients with chronic kidney disease (CKD). Septic arthritis due to Mycobacterium avium-intracellulare (MAI) is a rare entity that can affect immunocompromised patients such as those with acquired immunodeficiency syndrome (AIDS) or those who are on immunosuppressive drugs. Here, we describe a 51-year-old female who presented with fever, right knee pain, swelling, warmth, and decreased range of motion for several days...
2016: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/27799824/profile-of-cabotegravir-and-its-potential-in-the-treatment-and-prevention-of-hiv-1-infection-evidence-to-date
#6
REVIEW
Thomas Whitfield, Adele Torkington, Clare van Halsema
Modern antiretroviral therapy has demonstrated effectiveness in preexposure prophylaxis (PrEP) and treatment of HIV infection. There is a demand for prevention and treatment regimens that could overcome challenges of improving adherence, toxicity, and dosing convenience. Cabotegravir is an integrase strand transfer inhibitor and an analog of dolutegravir. Unlike dolutegravir, cabotegravir has a long half-life and can be formulated into a long-acting nanosuspension for parenteral administration. Initial pharmokinetic studies in humans have demonstrated adequate drug levels with intramuscular (IM) administration at 4 weekly and 8 weekly intervals, with few interactions with commonly used concomitant medications...
2016: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/27799651/diagnosis-of-visceral-leishmaniasis-using-peripheral-blood-microscopy-in-ethiopia-a-prospective-phase-iii-study-of-the-diagnostic-performance-of-different-concentration-techniques-compared-to-tissue-aspiration
#7
Ermias Diro, Cedric Yansouni, Yegnasew Takele, Bewketu Mengesha, Lutgarde Lynen, Asrat Hailu, Johan van Griensven, Marleen Boelaert, Philippe Büscher
Visceral leishmaniasis (VL) is a fatal parasitic disease. Unfortunately, diagnosis of VL in east Africa currently relies on aspiration of tissue from the spleen or bone marrow, which is painful and potentially dangerous. We sought to determine whether peripheral blood could be used instead of invasive tissue aspirates to diagnose VL, using three parasite concentration techniques. Three hundred and one consecutive people suspected of having VL were recruited. Compared with microscopy of tissue aspirates, the diagnostic accuracy of peripheral blood microscopy was as follows: whole blood thin smear sensitivity 1...
October 31, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27798775/attitudes-toward-naloxone-prescribing-in-clinical-settings-a-qualitative-study-of-patients-prescribed-high-dose-opioids-for-chronic-non-cancer-pain
#8
Shane R Mueller, Stephen Koester, Jason M Glanz, Edward M Gardner, Ingrid A Binswanger
BACKGROUND: Over the last 2 decades, medical providers have increasingly prescribed pharmaceutical opioids for chronic non-cancer pain, while opioid overdose death rates have quadrupled. Naloxone, an opioid antagonist, can be prescribed to patients with chronic pain to reverse an opioid overdose, yet little is known about how patients perceive this emerging practice. OBJECTIVE: This study assessed the knowledge and attitudes toward naloxone prescribing among non-cancer patients prescribed opioids in primary care...
October 31, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27796941/hepatic-porphyria-a-narrative-review
#9
REVIEW
Sumant Arora, Steven Young, Sudha Kodali, Ashwani K Singal
Porphyrias are a group of metabolic disorders, which result from a specific abnormality in one of the eight enzymes of the heme biosynthetic pathway. These have been subdivided based on the predominant site of enzyme defect into hepatic and erythropoietic types and based on clinical presentation into acute neurovisceral and cutaneous blistering porphyrias. This review focuses on hepatic porphyrias, which include acute intermittent porphyria (AIP), variegate porphyria (VP), hereditary coproporphyria (HCP), aminolevulinic acid dehydratase deficiency porphyria (ADP), and porphyria cutanea tarda (PCT)...
October 31, 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27788232/diagnostic-utility-of-ocular-symptoms-and-vision-for-cytomegalovirus-retinitis
#10
Yingna Liu, Alexander S Chen, Siripim Kamphaengkham, Prattana Leenasirimakul, Choeng Jirawison, Somsanguan Ausayakhun, Todd P Margolis, Jeremy D Keenan
PURPOSE: Cytomegalovirus (CMV) retinitis remains a leading cause of blindness in countries with a high burden of AIDS. Although dilated fundus examinations are recommended for those with CD4 counts below 100 cells/μL, in practice only those with poor vision and/or symptoms are routinely referred for screening. Therefore, the predictive value of this common practice should be assessed. METHODS: This is a prospective cross-sectional study. Patients with known HIV and a CD4 count of less than 100 cells/μL attending an HIV clinic in Chiang Mai, Thailand completed a standardized questionnaire about visual symptoms and underwent visual acuity testing and dilated fundus examination...
2016: PloS One
https://www.readbyqxmd.com/read/27787674/pain-and-risk-behaviors-among-hiv-infected-persons-in-st-petersburg-russia
#11
Judith I Tsui, Debbie M Cheng, Sharon M Coleman, Elena Blokhina, Natalia Gnatienko, Kendall Bryant, Evgeny Krupitsky, Edwin Zvartau, Jeffrey H Samet
We analyzed baseline data from an observational cohort of HIV-infected ART-naïve patients in St. Petersburg, Russia to explore whether pain was associated with HIV risk behaviors. The primary outcomes were (1) unprotected vaginal or anal sex in the past 90 days and (2) sharing of needles or equipment in the past month. Secondary outcomes included: use of alcohol prior to sex, current injection drug use, number of unprotected sex and sharing episodes, and days injected in the past month. The main independent variable was any past week pain...
October 27, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27787673/patient-provider-engagement-and-chronic-pain-in-drug-using-primarily-african-american-persons-living-with-hiv-aids
#12
Mary M Mitchell, Trang Q Nguyen, Allysha C Maragh-Bass, Sarina R Isenberg, Mary Catherine Beach, Amy R Knowlton
Among disadvantaged persons living with HIV/AIDS (PLHIV), patient-provider engagement, which has been defined as patient-provider relationships that promote the use of health care services and are characterized by active listening and supportive decision making, has been associated with antiretroviral therapy (ART) maintenance and viral suppression. However, chronic pain, depression, and substance use, all of which are prevalent in this population, can reduce the quality of patient-provider engagement. We hypothesized a model in which chronic pain, depression, and substance use would be associated with poorer patient-provider engagement, which would be positively associated with adherence, with the latter associated positively with viral suppression...
October 27, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27781103/ageing-and-menopause-considerations-for-women-with-hiv-in-the-uk
#13
EDITORIAL
L Sherr, A Molloy, A Macedo, N Croome, M A Johnson
OBJECTIVES: Treatment rollout has dramatically improved life expectancy for people with HIV and AIDS. Women represent a substantial proportion of patients in the UK (approximately one-third of patients in care are female according to the HIV Annual Report 2014). This study examines psychosocial and biomedical issues for women diagnosed with HIV in the UK, comparing those above and below 45 years of age to examine menopause and ageing issues. METHODS: Consecutive clinic attenders in a large outpatient London HIV clinic were invited to participate in the study...
October 5, 2016: Journal of Virus Eradication
https://www.readbyqxmd.com/read/27768079/exergaming-in-older-people-living-with-hiv-improves-balance-mobility-and-ameliorates-some-aspects-of-frailty
#14
Suhitha Veeravelli, Bijan Najafi, Ivan Marin, Fernando Blumenkron, Shannon Smith, Stephen A Klotz
Approximately 1.2 million people in the United States live with HIV infection. Medical advancements have increased the life expectancy and this cohort is aging. HIV-positive individuals have a high incidence of frailty (~20%) characterized by depression and sedentary behavior. Exercise would be healthy, but due to the frail status of many HIV-positive individuals, conventional exercise is too taxing. The aim of this study was to evaluate the effectiveness and acceptability of a novel game-based training program (exergame) in ameliorating some aspects of frailty in HIV-infected individuals...
October 6, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27765666/safety-efficacy-and-pharmacokinetics-of-a-single-tablet-regimen-containing-elvitegravir-cobicistat-emtricitabine-and-tenofovir-alafenamide-in-treatment-naive-hiv-infected-adolescents-a-single-arm-open-label-trial
#15
Aditya H Gaur, Hilda Kizito, Wasana Prasitsueubsai, Natella Rakhmanina, Mohammed Rassool, Rana Chakraborty, Jagmohan Batra, Pope Kosalaraksa, Wicharn Luesomboon, Danielle Porter, Yongwu Shao, Michael Myers, Lillian Ting, Devi SenGupta, Erin Quirk, Martin S Rhee
BACKGROUND: The prodrug tenofovir alafenamide is associated with improved renal and bone safety compared with tenofovir disoproxil fumarate. We aimed to assess safety, pharmacokinetics, and efficacy of this single-tablet, fixed-dose combination of elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in HIV-infected, treatment-naive adolescents. METHODS: We did a 48 week, single-arm, open-label trial in treatment-naive adolescents with HIV from ten hospital clinics in South Africa, Thailand, Uganda, and the USA...
December 2016: Lancet HIV
https://www.readbyqxmd.com/read/27765581/anogenital-infection-by-chlamydia-trachomatis-and-neisseria-gonorrhoeae-in-hiv-infected-men-and-women-in-salvador-brazil
#16
Ana Gabriela Travassos, Eveline Xavier Pereira de Souza, Eduardo Netto, Eda Vinhaes Dantas, Maiara Timbó, Isabella Nóbrega, Tatiana Haguihara, Júlia Maria de Oliveira Neumeyer, Nathalia Araújo Lisboa, Maria Angela Soidan, Fábio Ferreira, Carlos Brites
BACKGROUND: Infections caused by Chlamydia trachomatis and Neisseria gonorrhoeae are the most common bacterial sexually transmitted infections throughout the world. These sexually transmitted infections are a growing problem in people living with HIV/AIDS. However, the presence of these agents in extra genital sites, remains poorly studied in our country. The objective of this study was to estimate the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae anal and genital infection in people living with HIV/AIDS followed in a reference center in Salvador, Brazil...
October 17, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27764177/development-validation-and-field-testing-of-an-instrument-for-clinical-assessment-of-hiv-associated-neuropathy-and-neuropathic-pain-in-resource-restricted-and-large-population-study-settings
#17
Yohannes W Woldeamanuel, Peter R Kamerman, Demetri G A Veliotes, Tudor J Phillips, David Asboe, Marta Boffito, Andrew S C Rice
HIV-associated sensory peripheral neuropathy (HIV-SN) afflicts approximately 50% of patients on antiretroviral therapy, and is associated with significant neuropathic pain. Simple accurate diagnostic instruments are required for clinical research and daily practice in both high- and low-resource setting. A 4-item clinical tool (CHANT: Clinical HIV-associated Neuropathy Tool) assessing symptoms (pain and numbness) and signs (ankle reflexes and vibration sense) was developed by selecting and combining the most accurate measurands from a deep phenotyping study of HIV positive people (Pain In Neuropathy Study-HIV-PINS)...
2016: PloS One
https://www.readbyqxmd.com/read/27761646/-viral-arthritis-and-vasculitis
#18
U Sixdorf, E Märker-Hermann
Viral arthritis and vasculitis are important differential diagnoses primarily in patients with acute polyarticular arthritis in association with fever and rash, in populations specially at risk and in returning travellers. Parvovirus B19 is the most frequent cause of viral arthritis in Europe, whereas rubella, hepatitis B and C viruses have become less common. Due to worldwide tourism arthritogenic alphaviruses, which are transmitted by mosquito vectors have come into the focus of tropical medicine and rheumatology...
October 19, 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27760883/evaluating-mobile-phone-applications-for-health-behaviour-change-a-systematic-review
#19
Fiona H McKay, Christina Cheng, Annemarie Wright, Jane Shill, Hugh Stephens, Mary Uccellini
INTRODUCTION: Increasing smartphones access has allowed for increasing development and use of smart phone applications (apps). Mobile health interventions have previously relied on voice or text-based short message services (SMS), however, the increasing availability and ease of use of apps has allowed for significant growth of smartphone apps that can be used for health behaviour change. This review considers the current body of knowledge relating to the evaluation of apps for health behaviour change...
October 18, 2016: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/27733282/global-regional-and-national-incidence-prevalence-and-years-lived-with-disability-for-310-diseases-and-injuries-1990-2015-a-systematic-analysis-for-the-global-burden-of-disease-study-2015
#20
COMMENT
(no author information available yet)
BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015...
October 8, 2016: Lancet
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