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Maximal lactate state

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https://www.readbyqxmd.com/read/28712262/evaluation-of-efforts-in-untrained-wistar-rats-following-exercise-on-forced-running-wheel-at-maximal-lactate-steady-state
#1
Sajjad Rezaei, Hamid Agha-Alinejad, Mahdieh Molanouri Shamsi, Mahvash Jafari, Fabricio Azevedo Voltarelli, Alireza Naderi, Conrad Earnest
PURPOSE: We aimed to examine the effect of running speed on metabolic responses associated with maximal lactate steady state (MLSS) in rats during forced running wheel (FRW) exercise. METHODS: Forty male adult Wistar rats were divided into seven groups. The blood lactate threshold and peak running speed were determined for an incremental power test group. Five groups participated in constant power tests at intensities 10, 13, 14.5, 16, and 17.5 m/min to determine MLSS and a non-exercise group was chosen as the control...
March 31, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28642717/the-lactate-minimum-test-concept-methodological-aspects-and-insights-for-future-investigations-in-human-and-animal-models
#2
REVIEW
Leonardo H D Messias, Claudio A Gobatto, Wladimir R Beck, Fúlvia B Manchado-Gobatto
In 1993, Uwe Tegtbur proposed a useful physiological protocol named the lactate minimum test (LMT). This test consists of three distinct phases. Firstly, subjects must perform high intensity efforts to induce hyperlactatemia (phase 1). Subsequently, 8 min of recovery are allowed for transposition of lactate from myocytes (for instance) to the bloodstream (phase 2). Right after the recovery, subjects are submitted to an incremental test until exhaustion (phase 3). The blood lactate concentration is expected to fall during the first stages of the incremental test and as the intensity increases in subsequent stages, to rise again forming a "U" shaped blood lactate kinetic...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28593171/withania-somnifera-targets-interleukin-8-and-cyclooxygenase-2-in-human-prostate-cancer-progression
#3
Anand Setty Balakrishnan, Abel Arul Nathan, Mukesh Kumar, Sudhakar Ramamoorthy, Sathish Kumar Ramia Mothilal
BACKGROUND: Prostate cancer (PC) is a common noncutaneous malignancy in men. The incidence of PC is increasing at an alarming rate across the globe. Progression of PC is associated with elevated levels of interleukin-8 (IL-8) and cyclooxygenase-2 (COX-2) in malignant cells. Overexpression of these players is accompanied by chronic inflammation, increased angiogenesis, proliferation, migration, and inhibition of apoptosis. Moreover, their elevated circulating levels promote the disease progression from androgen-dependent to androgen-independent state...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28583599/serum-concentration-dynamic-of-energy-homeostasis-hormones-leptin-insulin-thyroid-hormones-and-cortisol-throughout-canine-pregnancy-and-lactation
#4
L Cardinali, A Troisi, J P Verstegen, L Menchetti, A Elad Ngonput, C Boiti, S Canello, R Zelli, A Polisca
Pregnancy and lactation represent critical periods of canine reproductive life and different hormones are required to maintain homeostasis and the correct energy requirements. The aim of this study was to evaluate leptin, insulin, triiodotyronine (T3), thyroxin (T4) and cortisol serum concentrations to better describe the canine maternal energy metabolism. Twelve Bloodhound bitches that had at least one litter and were considered to be healthy submitted blood samples every 15 days starting from day 0 (ovulation) throughout pregnancy up to the end of lactation (day 120)...
July 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28526448/the-catechol-o-methyltransferase-inhibitors-tolcapone-and-entacapone-uncouple-and-inhibit-the-mitochondrial-respiratory-chain-in-heparg-cells
#5
David Grünig, Andrea Felser, Jamal Bouitbir, Stephan Krähenbühl
The catechol-O-methyltransferase inhibitor tolcapone causes hepatotoxicity and mitochondrial damage in animal models. We studied the interaction of tolcapone with mitochondrial respiration in comparison to entacapone in different experimental models. In HepaRG cells (human cell-line), tolcapone decreased the ATP content (estimated IC50 100±15μM) and was cytotoxic (estimated IC50 333±45μM), whereas entacapone caused no cytotoxicity and no ATP depletion up to 200μM. Cytochrome P450 induction did not increase the toxicity of the compounds...
May 16, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28499395/time-course-of-blood-lactate-levels-inflammation-and-mitochondrial-function-in-experimental-sepsis
#6
Thiago Domingos Corrêa, Adriano José Pereira, Sebastian Brandt, Madhusudanarao Vuda, Siamak Djafarzadeh, Jukka Takala, Stephan Mathias Jakob
BACKGROUND: A decrease in blood lactate levels (Lac) >10% during the first hours of resuscitation in sepsis is associated with better outcomes, but the mechanisms are unclear. Our objective was to investigate the relationship between the time course of Lac, inflammatory response, and mitochondrial respiration during experimental sepsis. METHODS: Original data from two previously published studies were reanalyzed. In cohort 1, pigs were randomized to be resuscitated for 48 h starting at 6, 12, and 24 h, respectively, after fecal peritonitis induction (n = 8 each)...
May 12, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28489460/a-preliminary-study-in-the-alterations-of-mitochondrial-respiration-in-patients-with-carbon-monoxide-poisoning-measured-in-blood-cells
#7
David H Jang, Matthew Kelly, Kevin Hardy, David S Lambert, Frances S Shofer, David M Eckmann
OBJECTIVES: Carbon monoxide (CO) is a colorless and odorless gas responsible for poisoning mortality and morbidity in the United States. At this time, there is no reliable method to predict the severity of poisoning or clinical prognosis following CO exposure. Whole blood cells, such as peripheral blood mononuclear cells (PBMCs) and platelets, have been explored for their potential use to act as sensitive biomarkers for mitochondrial dysfunction which may have a role in CO poisoning. DESIGN: The objective of this study was to measure mitochondrial respiration using intact cells obtained from patients exposed to CO as a potential biomarker for mitochondrial inhibition with results that can be obtained in a time frame useful for guiding clinical care...
July 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28488826/soccer-training-high-intensity-interval-training-is-mood-disturbing-while-small-sided-games-ensure-mood-balance
#8
Okba Selmi, Monoem Haddad, Lina Majed, Wissam Ben Khalifa, Marzougui Hamza, Karim Chamari
BACKGROUNDː The aim of the study was to compare the effects of high-intensity intermittent training (HIIT) versus small-sided games (SSG) in soccer on both the physiological responses and the mood state of players. METHODS: Sixteen professional soccer players took part in the study (age: 24.1±0.9 years). Testing of players was conducted on separate days in a randomized and counter-balanced order (each training session: 28-min: 4x4 minutes work with 3-min of passive recovery in-between)...
May 9, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28345160/increasing-skeletal-muscle-carnitine-availability-does-not-alter-the-adaptations-to-high-intensity-interval-training
#9
Christopher E Shannon, Reza Ghasemi, Paul L Greenhaff, Francis B Stephens
Increasing skeletal muscle carnitine availability alters muscle metabolism during steady-state exercise in healthy humans. We investigated whether elevating muscle carnitine, and thereby the acetyl-group buffering capacity, altered the metabolic and physiological adaptations to 24 weeks of high-intensity interval training (HIIT) at 100% maximal exercise capacity (Wattmax ). Twenty-one healthy male volunteers (age 23±2 years; BMI 24.2±1.1 kg/m(2) ) performed 2 × 3 minute bouts of cycling exercise at 100% Wattmax , separated by 5 minutes of rest...
March 27, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28302463/critical-power-testing-or-self-selected-cycling-which-one-is-the-best-predictor-of-maximal-metabolic-steady-state
#10
Felipe Mattioni Maturana, Daniel A Keir, Kaitlin M McLay, Juan M Murias
Critical power (CP) demarcates the boundary between heavy and very heavy exercise intensity domains, and therefore, the power output (PO) that can be sustained at the maximal metabolic steady-state during constant-PO exercise (i.e., maximal lactate steady-state (MLSS)). However, the estimated CP does not always reflect a sustainable intensity of exercise, where blood lactate concentration ([La]) and oxygen uptake (V˙O2) reach a plateau. OBJECTIVES: To test cyclists' ability to predict their highest PO associated with metabolic steady-state based on their own perception of effort...
January 24, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28282663/reliability-and-validity-of-a-new-specific-field-test-of-aerobic-capacity-with-the-ball-for-futsal-players
#11
Ricardo Barbieri, Fabio Barbieri, Fabio Milioni, Julio Dos-Santos, Marcelo Soares, Alessandro Zagatto, Marcelo Papoti
The aim of this study was to establish the validity and reliability and verification of the reproducibility of the lactate minimum test (LM) to predict the maximal lactate steady state exercise intensity (MLSS) on a futsal-specific circuit (Futsal_circuit) which takes into consideration the technical movements performed. 16 male Brazilian futsal players (body mass: 67.7±8.3 kg; height: 1.73±0.05 m) were distributed randomly into 2 studies with 8 athletes in each (Study A - reproducibility; Study B - validity)...
March 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28245246/oxygen-uptake-kinetics-and-energy-system-s-contribution-around-maximal-lactate-steady-state-swimming-intensity
#12
Jailton Gregório Pelarigo, Leandro Machado, Ricardo Jorge Fernandes, Camila Coelho Greco, João Paulo Vilas-Boas
The purpose of this study was to examine the oxygen uptake ([Formula: see text]) kinetics and the energy systems' contribution at 97.5, 100 and 102.5% of the maximal lactate steady state (MLSS) swimming intensity. Ten elite female swimmers performed three-to-five 30 min submaximal constant swimming bouts at imposed paces for the determination of the swimming velocity (v) at 100%MLSS based on a 7 x 200 m intermittent incremental protocol until voluntary exhaustion to find the v associated at the individual anaerobic threshold...
2017: PloS One
https://www.readbyqxmd.com/read/28240707/comparison-of-different-methods-for-the-swimming-aerobic-capacity-evaluation
#13
Jailton Gregório Pelarigo, Ricardo Jorge Fernandes, João Ribeiro, Benedito Sérgio Denadai, Camila Coelho Greco, João Paulo Vilas-Boas
This study compared velocity (v) and bioenergetical factors using different methods applied for the swimming aerobic capacity evaluation. Ten elite female swimmers (17.6 ± 1.9 yrs., 1.70 ± 0.05 m and 61.3 ± 5.8 kg) performed an intermittent incremental velocity protocol until voluntary exhaustion to determine the v associated to the individual anaerobic threshold (IAnT), ventilatory threshold (VT), heart rate threshold (HRT), lactate threshold fixed in 3.5 mmol.L (LT3.5) and maximal oxygen uptake (V[Combining Dot Above]O2max)...
February 23, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28128633/reliability-of-time-to-exhaustion-and-selected-psycho-physiological-variables-during-constant-load-cycling-at-the-maximal-lactate-steady-state
#14
Oliver Faude, Anne Hecksteden, Daniel Hammes, Franck Schumacher, Eric Besenius, Billy Sperlich, Tim Meyer
The maximal lactate steady-state (MLSS) is frequently assessed for prescribing endurance exercise intensity. Knowledge of the intra-individual variability of the MLSS is important for practical application. To date, little is known about the reliability of time-to-exhaustion and physiological responses to exercise at MLSS. Twenty-one healthy men (age, 25.2 (SD 3.3) years; height, 1.83 (0.06) m; body mass, 78.9 (8.9) kg; maximal oxygen uptake, 57.1 (10.7) mL·min(-1)·kg(-1)) performed 1 incremental exercise test, and 2 constant-load tests to determine MLSS intensity...
February 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28090142/the-midpoint-between-ventilatory-thresholds-approaches-maximal-lactate-steady-state-intensity-in-amateur-cyclists
#15
A B Peinado, Dm Pessôa Filho, V Díaz, P J Benito, M Álvarez-Sánchez, A G Zapico, F J Calderón
The aim was to determine whether the midpoint between ventilatory thresholds (MPVT) corresponds to maximal lactate steady state (MLSS). Twelve amateur cyclists (21.0 ± 2.6 years old; 72.2 ± 9.0 kg; 179.8 ± 7.5 cm) performed an incremental test (25 W·min(-1)) until exhaustion and several constant load tests of 30 minutes to determine MLSS, on different occasions. Using MLSS determination as the reference method, the agreement with five other parameters (MPVT; first and second ventilatory thresholds: VT1 and VT2; respiratory exchange ratio equal to 1: RER = 1...
December 2016: Biology of Sport
https://www.readbyqxmd.com/read/28044281/the-effects-of-mental-fatigue-on-physical-performance-a-systematic-review
#16
REVIEW
Jeroen Van Cutsem, Samuele Marcora, Kevin De Pauw, Stephen Bailey, Romain Meeusen, Bart Roelands
BACKGROUND: Mental fatigue is a psychobiological state caused by prolonged periods of demanding cognitive activity. It has recently been suggested that mental fatigue can affect physical performance. OBJECTIVE: Our objective was to evaluate the literature on impairment of physical performance due to mental fatigue and to create an overview of the potential factors underlying this effect. METHODS: Two electronic databases, PubMed and Web of Science (until 28 April 2016), were searched for studies designed to test whether mental fatigue influenced performance of a physical task or influenced physiological and/or perceptual responses during the physical task...
August 2017: Sports Medicine
https://www.readbyqxmd.com/read/28033123/accuracy-of-a-modified-lactate-minimum-test-and-reverse-lactate-threshold-test-to-determine-maximal-lactate-steady-state
#17
Patrick Wahl, Christian Manunzio, Florian Vogt, Sarah Strütt, Prisca Volmary, Wilhelm Bloch, Joachim Mester
This study evaluated the accuracy of a modified-lactate-minimum-test (mLMT), a modified-reverse-lactate-threshold-test (mRLT), in comparison to two established threshold concepts (OBLA & mDmax) to determine power output at maximal-lactate-steady-state (MLSS) in cycling. Nineteen subjects performed an mLMT, an mRLT, a graded-exercise-test (100W start, +20W every 3 min) and 3 or more constant-load tests of 30 minutes to determine power output at MLSS. The mLMT and mRLT both consisted of an initial lactate priming-segment, followed by a short recovery phase...
December 20, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28006434/lactate-minimum-underestimates-the-maximal-lactate-steady-state-in-swimming-mice
#18
COMPARATIVE STUDY
Natalia Almeida Rodrigues, Adriana Souza Torsoni, Thais Fante, Ivan Gustavo Masselli Dos Reis, Claudio Alexandre Gobatto, Fúlvia Barros Manchado-Gobatto
The intensity of lactate minimum (LM) has presented a good estimate of the intensity of maximal lactate steady-state (MLSS); however, this relationship has not yet been verified in the mouse model. We proposed validating the LM protocol for swimming mice by investigating the relationship among intensities of LM and MLSS as well as differences between sexes, in terms of aerobic capacity. Nineteen mice (male: 10, female: 9) were submitted to the evaluation protocols for LM and MLSS. The LM protocol consisted of hyperlactatemia induction (30 s exercise (13% body mass (bm)), 30 s resting pause and exhaustive exercise (13% bm), 9 min resting pause and incremental test)...
January 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27918656/aerobic-evaluation-in-elite-slalom-kayakers-using-tethered-canoe-system-a-new-proposal
#19
Homero Gustavo Ferrari, Leonardo H D Messias, Ivan G M Reis, Claudio A Gobatto, Filipe A B Sousa, Camila C S Serra, Fúlvia B Manchado-Gobatto
BACKGROUND: Among other aspects, aerobic fitness is indispensable for performance in slalom canoe. PURPOSE: The aims of the study were to propose the maximal lactate steady state (MLSS) and critical force (CF) tests using a tethered canoe system as new strategies for aerobic evaluation in elite slalom kayakers. Also, we studied the relationship between the aerobic parameters from these tests and the kayakers' performances. METHODS: Twelve male elite slalom kayakers from the Brazilian National Team participated in this study...
December 5, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27917127/maternal-high-fat-diet-alters-skeletal-muscle-mitochondrial-catalytic-activity-in-adult-male-rat-offspring
#20
Chantal A Pileggi, Christopher P Hedges, Stephanie A Segovia, James F Markworth, Brenan R Durainayagam, Clint Gray, Xiaoyuan D Zhang, Matthew P G Barnett, Mark H Vickers, Anthony J R Hickey, Clare M Reynolds, David Cameron-Smith
A maternal high-fat (HF) diet during pregnancy can lead to metabolic compromise, such as insulin resistance in adult offspring. Skeletal muscle mitochondrial dysfunction is one mechanism contributing to metabolic impairments in insulin resistant states. Therefore, the present study aimed to investigate whether mitochondrial dysfunction is evident in metabolically compromised offspring born to HF-fed dams. Sprague-Dawley dams were randomly assigned to receive a purified control diet (CD; 10% kcal from fat) or a high fat diet (HFD; 45% kcal from fat) for 10 days prior to mating, throughout pregnancy and during lactation...
2016: Frontiers in Physiology
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