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Maximal lactate state

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https://www.readbyqxmd.com/read/29895681/cardiac-mitochondrial-metabolism-may-contribute-to-differences-in-thermal-tolerance-of-red-and-white-blooded-antarctic-notothenioid-fishes
#1
Kristin M O'Brien, Anna S Rix, Stuart Egginton, Anthony P Farrell, Elizabeth L Crockett, Karen Schlauch, Rebekah Woolsey, Megan Hoffman, Sean Merriman
Studies in temperate fishes provide evidence that cardiac mitochondrial function and the capacity to fuel cardiac work contributes to thermal tolerance. Here we tested the hypothesis that decreased cardiac aerobic metabolic capacity contributes to the lower thermal tolerance of the haemoglobinless Antarctic icefish, Chaenocephalus aceratus , compared to the red-blooded Antarctic species, Notothenia coriiceps. Maximal activities of citrate synthase (CS) and lactate dehydrogenase (LDH), respiration rates of isolated mitochondria, adenylate levels, and changes in mitochondrial protein expression were quantified from hearts of animals held at ambient temperature or exposed to their critical thermal maximum (CTMAX )...
June 12, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29877961/endovascular-perfusion-augmentation-for-critical-care-partial-aortic-occlusion-for-treatment-of-severe-ischemia-reperfusion-shock
#2
M Austin Johnson, Emily M Tibbits, Guillaume L Hoareau, Meryl A Simon, Anders J Davidson, Erik S DeSoucy, E Robert Faulconer, J Kevin Grayson, Lucas P Neff, Timothy K Williams
BACKGROUND: The resuscitation of patients in shock is materially intensive and many patients are refractory to maximal therapy. We hypothesized that partial inflation of an intra-aortic balloon, termed Endovascular Perfusion Augmentation for Critical Care (EPACC), would minimize material requirements while improving physiologic metrics. METHODS: Swine underwent a 25% controlled bleed and 45 minutes of complete aortic occlusion to create a severe ischemia-reperfusion shock state...
June 5, 2018: Shock
https://www.readbyqxmd.com/read/29803737/an-equation-to-predict-the-maximal-lactate-steady-state-from-ramp-incremental-exercise-test-data-in-cycling
#3
Danilo Iannetta, Federico Y Fontana, Felipe Mattioni Maturana, Erin Calaine Inglis, Silvia Pogliaghi, Daniel A Keir, Juan M Murias
OBJECTIVES: The maximal lactate steady state (MLSS) represents the highest exercise intensity at which an elevated blood lactate concentration ([Lac]b ) is stabilized above resting values. MLSS quantifies the boundary between the heavy-to-very-heavy intensity domains but its determination is not widely performed due to the number of trials required. DESIGN: This study aimed to: (i) develop a mathematical equation capable of predicting MLSS using variables measured during a single ramp-incremental cycling test and (ii) test the accuracy of the optimized mathematical equation...
May 23, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29795741/simulated-altitude-via-re-breathing-creates-arterial-hypoxemia-but-fails-to-improve-elements-of-running-performance
#4
Matthew J Garver, Cory M Scheadler, Logan M Smith, Sarah J Taylor, Chase M Harbach
Acclimatization to altitude has been shown to improve elements of performance. Use of simulated altitude is popular among athletes across the sports spectrum. This work was on a handheld, re-breathing device touted to enhance performance. Seven recreationally-trained athletes used the device for 18 hours over the course of the 37-day intervention trial. The elevations simulated were progressively increased from 1,524m to 6,096m. To ascertain potential efficacy, four performance trials were included (familiarization, baseline, and 2 follow-ups)...
2018: International Journal of Exercise Science
https://www.readbyqxmd.com/read/29785087/transcriptomic-impacts-of-rumen-epithelium-induced-by-butyrate-infusion-in-dairy-cattle-in-dry-period
#5
Ransom L Baldwin, Robert W Li, Yankai Jia, Cong-Jun Li
The purpose of this study was to evaluate the effects of butyrate infusion on rumen epithelial transcriptome. Next-generation sequencing (NGS) and bioinformatics are used to accelerate our understanding of regulation in rumen epithelial transcriptome of cattle in the dry period induced by butyrate infusion at the level of the whole transcriptome. Butyrate, as an essential element of nutrients, is a histone deacetylase (HDAC) inhibitor that can alter histone acetylation and methylation, and plays a prominent role in regulating genomic activities influencing rumen nutrition utilization and function...
2018: Gene Regulation and Systems Biology
https://www.readbyqxmd.com/read/29775989/higher-accuracy-of-the-lactate-minimum-test-compared-to-established-threshold-concepts-to-determine-maximal-lactate-steady-state-in-running
#6
Patrick Wahl, Lukas Zwingmann, Christian Manunzio, Jacob Wolf, Wilhelm Bloch
This study evaluated the accuracy of the lactate minimum test, in comparison to a graded-exercise test and established threshold concepts (OBLA and mDmax) to determine running speed at maximal lactate steady state. Eighteen subjects performed a lactate minimum test, a graded-exercise test (2.4 m·s-1 start,+0.4 m·s-1 every 5 min) and 2 or more constant-speed tests of 30 min to determine running speed at maximal lactate steady state. The lactate minimum test consisted of an initial lactate priming segment, followed by a short recovery phase...
May 18, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29651253/a-lactate-kinetics-method-for-assessing-the-maximal-lactate-steady-state-workload
#7
Gernot O Hering, Ewald M Hennig, Hartmut J Riehle, Jens Stepan
During a continuously increasing exercise workload (WL) a point will be reached at which arterial lactate accumulates rapidly. This so-called lactate threshold (LT) is associated with the maximal lactate steady state workload (MLSSW ), the highest WL, at which arterial lactate concentration [LA] does not change. However, the physiological range in which the LT and the MLSSW occur has not been demonstrated directly. We used minor WL variations in the MLSSW range to assess arterial lactate kinetics in 278 treadmill and 148 bicycle ergometer exercise tests...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29368654/identifying-individual-animal-factors-associated-with-mycobacterium-avium-subsp-paratuberculosis-map-milk-elisa-positivity-in-dairy-cattle-in-the-midwest-region-of-the-united-states
#8
Gustavo Machado, Kaushi Kanankege, Val Schumann, Scott Wells, Andres Perez, Julio Alvarez
BACKGROUND: Mycobacterium avium subsp. paratuberculosis (MAP) is a widespread chronic disease of ruminants that causes severe economic losses to the dairy cattle industry worldwide. The objective of this study was to evaluate the association between individual cow MAP-ELISA and relevant milk production predictors in dairy cattle using data routinely collected as part of quality and disease control programs in the Midwest region of the U.S. Milk ELISA results of 45,652 animals from 691 herds from November 2014 to August 2016 were analyzed...
January 25, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29290449/lactation-response-to-soybean-meal-and-rumen-protected-methionine-supplementation-of-corn-silage-based-diets
#9
H Nursoy, M Gonzalez Ronquillo, A P Faciola, G A Broderick
Corn silage, an important forage fed to dairy cows in the United States, is energy rich but protein poor. The objectives of this experiment were to investigate the effects on production of milk and milk components of feeding corn silage-based diets with 4 levels of dietary crude protein (CP) plus rumen-protected methionine (RPM). Thirty-six cows were blocked by days in milk into 9 squares and randomly assigned to 9 balanced 4 × 4 Latin squares with four 4-wk periods. All diets were formulated to contain, as a percent of dry matter (DM), 50% corn silage, 10% alfalfa silage, 4% soyhulls, 2...
March 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29163332/clinical-use-of-cerebral-microdialysis-in-patients-with-aneurysmal-subarachnoid-hemorrhage-state-of-the-art
#10
REVIEW
Raimund Helbok, Mario Kofler, Alois Josef Schiefecker, Maxime Gaasch, Verena Rass, Bettina Pfausler, Ronny Beer, Erich Schmutzhard
Objective: To review the published literature on the clinical application of cerebral microdialysis (CMD) in aneurysmal subarachnoid hemorrhage (SAH) patients and to summarize the evidence relating cerebral metabolism to pathophysiology, secondary brain injury, and outcome. Methods: Study selection : Two reviewers identified all manuscripts reporting on the clinical use of CMD in aneurysmal SAH patients from MEDLINE. All identified studies were grouped according to their focus on brain metabolic changes during the early and subacute phase after SAH, their association with mechanisms of secondary brain injury and outcome...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29161112/reply-to-discussion-of-can-measures-of-critical-power-precisely-estimate-the-maximal-metabolic-steady-state-is-it-still-necessary-to-compare-critical-power-to-maximal-lactate-steady-state-when-is-it-appropriate-to-compare-critical-power-to-maximal-lactate-steady
#11
Daniel A Keir, Felipe Mattioni Maturana, Juan M Murias
No abstract text is available yet for this article.
January 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29161111/discussion-of-can-measures-of-critical-power-precisely-estimate-the-maximal-metabolic-steady-state-is-it-still-necessary-to-compare-critical-power-to-maximal-lactate-steady-state
#12
Ricardo Dantas de Lucas
No abstract text is available yet for this article.
January 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29148629/carbohydrate-mouth-rinse-improves-cycling-performance-carried-out-until-the-volitional-exhaustion
#13
Bruno Bavaresco Gambassi, Ylana Gomes de Santana Barros Leal, Edson R Pinheiro Dos Anjos, Bruna A Antonelli, Daniela C Gomes Gonçalves E Silva, Iracema H Pires de Mélo Montenegro, Rita di Cássia de Oliveira Angelo, Isis S Correia Moura, Paulo A Schwingel
BACKGROUND: Carbohydrates (CHO) are among the most investigated nutritional ergogenic aids, and may be consumed in different forms, e.g., mouth rinse with carbohydrate solution (MRCS). In this sense, the aim of this study was to evaluate the impact of MRCS on the performance of physically active individuals undergoing a physical exercise session carried out until the volitional exhaustion. METHODS: This is a counter-balanced randomized study, with a double-blind design...
November 17, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29035635/effects-of-varying-the-step-duration-on-the-determination-of-lactate-thresholds-in-elite-rowers
#14
Pitre C Bourdon, Sarah M Woolford, Jonathan D Buckley
This study aimed to identify the minimum increment duration required to accurately assess two distinct lactate thresholds. Twenty-one elite rowers (12 female, 9 males) each performed 8-9 rowing tests comprising: 1) five progressive incremental tests (3, 4, 5, 7 or 10 min steps); and 2) at least three 30-min constant-intensity maximal lactate steady state (MLSS) assessments. Power output (PO) at lactate threshold 1 (LT1) was higher in the 3- and 4-min incremental tests. No other measures were different for LT1...
October 16, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28952829/mental-fatigue-and-physical-and-cognitive-performance-during-a-2-bout-exercise-test
#15
Susan Vrijkotte, Romain Meeusen, Cloe Vandervaeren, Luk Buyse, Jeroen van Cutsem, Nathalie Pattyn, Bart Roelands
PURPOSE: The 2-bout exercise protocol has been developed to diagnose nonfunctional overreaching and the "overtraining syndrome." It consists of 2 maximal exercise bouts separated by 4 hours. Mental fatigue negatively influences performance, but the effects of its occurrence during the 2-bout exercise protocol have never been investigated. The aim of this study was to examine whether mental fatigue (induced during the rest period) influences physical and cognitive performance during/after the second exercise bout of the 2-bout exercise protocol...
April 1, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28712262/evaluation-of-efforts-in-untrained-wistar-rats-following-exercise-on-forced-running-wheel-at-maximal-lactate-steady-state
#16
Sajjad Rezaei, Hamid Agha-Alinejad, Mahdieh Molanouri Shamsi, Mahvash Jafari, Fabricio Azevedo Voltarelli, Alireza Naderi, Conrad Earnest
PURPOSE: We aimed to examine the effect of running speed on metabolic responses associated with maximal lactate steady state (MLSS) in rats during forced running wheel (FRW) exercise. METHODS: Forty male adult Wistar rats were divided into seven groups. The blood lactate threshold and peak running speed were determined for an incremental power test group. Five groups participated in constant power tests at intensities 10, 13, 14.5, 16, and 17.5 m/min to determine MLSS and a non-exercise group was chosen as the control...
March 31, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28642717/the-lactate-minimum-test-concept-methodological-aspects-and-insights-for-future-investigations-in-human-and-animal-models
#17
REVIEW
Leonardo H D Messias, Claudio A Gobatto, Wladimir R Beck, Fúlvia B Manchado-Gobatto
In 1993, Uwe Tegtbur proposed a useful physiological protocol named the lactate minimum test (LMT). This test consists of three distinct phases. Firstly, subjects must perform high intensity efforts to induce hyperlactatemia (phase 1). Subsequently, 8 min of recovery are allowed for transposition of lactate from myocytes (for instance) to the bloodstream (phase 2). Right after the recovery, subjects are submitted to an incremental test until exhaustion (phase 3). The blood lactate concentration is expected to fall during the first stages of the incremental test and as the intensity increases in subsequent stages, to rise again forming a "U" shaped blood lactate kinetic...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28593171/withania-somnifera-targets-interleukin-8-and-cyclooxygenase-2-in-human-prostate-cancer-progression
#18
Anand Setty Balakrishnan, Abel Arul Nathan, Mukesh Kumar, Sudhakar Ramamoorthy, Sathish Kumar Ramia Mothilal
BACKGROUND: Prostate cancer (PC) is a common noncutaneous malignancy in men. The incidence of PC is increasing at an alarming rate across the globe. Progression of PC is associated with elevated levels of interleukin-8 (IL-8) and cyclooxygenase-2 (COX-2) in malignant cells. Overexpression of these players is accompanied by chronic inflammation, increased angiogenesis, proliferation, migration, and inhibition of apoptosis. Moreover, their elevated circulating levels promote the disease progression from androgen-dependent to androgen-independent state...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28583599/serum-concentration-dynamic-of-energy-homeostasis-hormones-leptin-insulin-thyroid-hormones-and-cortisol-throughout-canine-pregnancy-and-lactation
#19
L Cardinali, A Troisi, J P Verstegen, L Menchetti, A Elad Ngonput, C Boiti, S Canello, R Zelli, A Polisca
Pregnancy and lactation represent critical periods of canine reproductive life and different hormones are required to maintain homeostasis and the correct energy requirements. The aim of this study was to evaluate leptin, insulin, triiodotyronine (T3), thyroxin (T4) and cortisol serum concentrations to better describe the canine maternal energy metabolism. Twelve Bloodhound bitches that had at least one litter and were considered to be healthy submitted blood samples every 15 days starting from day 0 (ovulation) throughout pregnancy up to the end of lactation (day 120)...
July 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28526448/the-catechol-o-methyltransferase-inhibitors-tolcapone-and-entacapone-uncouple-and-inhibit-the-mitochondrial-respiratory-chain-in-heparg-cells
#20
David Grünig, Andrea Felser, Jamal Bouitbir, Stephan Krähenbühl
The catechol-O-methyltransferase inhibitor tolcapone causes hepatotoxicity and mitochondrial damage in animal models. We studied the interaction of tolcapone with mitochondrial respiration in comparison to entacapone in different experimental models. In HepaRG cells (human cell-line), tolcapone decreased the ATP content (estimated IC50 100±15μM) and was cytotoxic (estimated IC50 333±45μM), whereas entacapone caused no cytotoxicity and no ATP depletion up to 200μM. Cytochrome P450 induction did not increase the toxicity of the compounds...
August 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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