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https://www.readbyqxmd.com/read/28936693/effects-of-intra-operative-fluoroscopic-3d-imaging-on-peri-operative-imaging-strategy-in-calcaneal-fracture-surgery
#1
M S H Beerekamp, M Backes, N W L Schep, D T Ubbink, J S Luitse, T Schepers, J C Goslings
INTRODUCTION: Previous studies demonstrated that intra-operative fluoroscopic 3D-imaging (3D-imaging) in calcaneal fracture surgery is promising to prevent revision surgery and save costs. However, these studies limited their focus to corrections performed after 3D-imaging, thereby neglecting corrections after intra-operative fluoroscopic 2D-imaging (2D-imaging). The aim of this study was to assess the effects of additional 3D-imaging on intra-operative corrections, peri-operative imaging used, and patient-relevant outcomes compared to 2D-imaging alone...
September 21, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28935923/formation-and-purification-of-tailored-liposomes-for-drug-delivery-using-a-module-based-micro-continuous-flow-system
#2
Nikolay Dimov, Elisabeth Kastner, Maryam Hussain, Yvonne Perrie, Nicolas Szita
Liposomes are lipid based bilayer vesicles that can encapsulate, deliver and release low-soluble drugs and small molecules to a specific target site in the body. They are currently exploited in several nanomedicine formulations. However, their development and application is still limited by expensive and time-consuming process development and production methods. Therefore, to exploit these systems more effectively and support the rapid translation of new liposomal nanomedicines from bench to bedside, new cost-effective and scalable production methods are needed...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935769/mof-derived-cobalt-nanoparticles-catalyze-a-general-synthesis-of-amines
#3
Rajenahally V Jagadeesh, Kathiravan Murugesan, Ahmad S Alshammari, Helfried Neumann, Marga-Martina Pohl, Jörg Radnik, Matthias Beller
The development of base metal catalysts for the synthesis of pharmaceutically relevant compounds remains an important goal of chemical research. Here, we report that cobalt nanoparticles encapsulated by a graphitic shell are broadly effective reductive amination catalysts. Their convenient and practical preparation entailed template assembly of cobalt-diamine-dicarboxylic acid metal organic frameworks on carbon and subsequent pyrolysis under inert atmosphere. The resulting stable and reusable catalysts were active for synthesis of primary, secondary, tertiary and N-methylamines (>140 examples)...
September 21, 2017: Science
https://www.readbyqxmd.com/read/28935360/when-guidelines-conflict-a-case-study-of-mammography-screening-initiation-in-the-1990s
#4
Mireille Jacobson, Srikanth Kadiyala
BACKGROUND: Cancer screening guidelines communicate important information to patients and physicians regarding the costs and benefits of screening. Currently, guideline recommendations from major organizations conflict regarding the age of mammography screening initiation. To understand current and future U.S. mammography screening patterns we study age-mammography patterns from the 1990s, another period of conflicting guideline recommendations. METHODS: We examine mammography use rates by single year of age to understand compliance with guideline-recommended initiation ages in the 1990s...
September 18, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28934608/chemical-free-fabrication-of-n-p-dual-doped-honeycomb-like-carbon-as-an-efficient-electrocatalyst-for-oxygen-reduction
#5
Lianwen Zhu, Jun Wu, Qiao Zhang, Xiangkui Li, Yiming Li, Xuebo Cao
Heteroatom-doped nanoporous carbons are now emerging as alternatives to platinum and its alloys as electrocatalysts to facilitate oxygen reduction reaction in metal-air batteries and fuel cells. However, the synthesis of nanoporous carbons usually involve in complicated procedures and intensive chemicals, which may dramatically raise their manufacture cost that even surpasses that of precious platinum. Herein, we demonstrate the single-step, chemical-free fabrication of N, P dualdoped honeycomb carbon that has hierarchically porous structure and oxygen electrocatalysis activity close to the benchmark Pt/C...
August 23, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28934320/household-costs-and-time-to-seek-care-for-pregnancy-related-complications-the-role-of-results-based-financing
#6
Jobiba Chinkhumba, Manuela De Allegri, Jacob Mazalale, Stephan Brenner, Don Mathanga, Adamson S Muula, Bjarne Robberstad
Results-based financing (RBF) schemes-including performance based financing (PBF) and conditional cash transfers (CCT)-are increasingly being used to encourage use and improve quality of institutional health care for pregnant women in order to reduce maternal and neonatal mortality in low-income countries. While there is emerging evidence that RBF can increase service use and quality, little is known on the impact of RBF on costs and time to seek care for obstetric complications, although the two represent important dimensions of access...
2017: PloS One
https://www.readbyqxmd.com/read/28933936/value-of-public-health-funding-in-preventing-hospital-bloodstream-infections-in-the-united-states
#7
Melanie D Whittington, Cathy J Bradley, Adam J Atherly, Jonathan D Campbell, Richard C Lindrooth
OBJECTIVES: To estimate the association of 1 activity of the Prevention and Public Health Fund with hospital bloodstream infections and calculate the return on investment (ROI). METHODS: The activity was funded for 1 year (2013). A difference-in-differences specification evaluated hospital standardized infection ratios (SIRs) before funding allocation (years 2011 and 2012) and after funding allocation (years 2013 and 2014) in the 15 US states that received the funding compared with hospital SIRs in states that did not receive the funding...
September 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28933487/scalable-cross-point-resistive-switching-memory-and-mechanism-through-an-understanding-of-h2o2-glucose-sensing-using-an-irox-al2o3-w-structure
#8
Somsubhra Chakrabarti, Siddheswar Maikap, Subhranu Samanta, Surajit Jana, Anisha Roy, Jian-Tai Qiu
The resistive switching characteristics of a scalable IrOx/Al2O3/W cross-point structure and its mechanism for pH/H2O2 sensing along with glucose detection have been investigated for the first time. Porous IrOx and Ir(3+)/Ir(4+) oxidation states are observed via high-resolution transmission electron microscope, field-emission scanning electron spectroscopy, and X-ray photo-electron spectroscopy. The 20 nm-thick IrOx devices in sidewall contact show consecutive long dc cycles at a low current compliance (CC) of 10 μA, multi-level operation with CC varying from 10 μA to 100 μA, and long program/erase endurance of >10(9) cycles with 100 ns pulse width...
September 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28933359/a-prospective-treatment-option-for-lysosomal-storage-diseases-crispr-cas9-gene-editing-technology-for-mutation-correction-in-induced-pluripotent-stem-cells
#9
REVIEW
Chloe L Christensen, Francis Y M Choy
Ease of design, relatively low cost and a multitude of gene-altering capabilities have all led to the adoption of the sophisticated and yet simple gene editing system: clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9). The CRISPR/Cas9 system holds promise for the correction of deleterious mutations by taking advantage of the homology directed repair pathway and by supplying a correction template to the affected patient's cells. Currently, this technique is being applied in vitro in human-induced pluripotent stem cells (iPSCs) to correct a variety of severe genetic diseases, but has not as of yet been used in iPSCs derived from patients affected with a lysosomal storage disease (LSD)...
February 24, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/28933002/mepolizumab-for-treating-severe-eosinophilic-asthma-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#10
REVIEW
Iñigo Bermejo, Matt Stevenson, Katy Cooper, Sue Harnan, Jean Hamilton, Mark Clowes, Christopher Carroll, Tim Harrison, Shironjit Saha
As part of its single technology appraisal (STA) process, the National Institute for Health and Care Excellence (NICE) invited the company (GlaxoSmithKline) that manufactures mepolizumab (Nucala(®)) to submit evidence on the clinical and cost effectiveness of mepolizumab for the treatment of severe eosinophilic asthma. The School of Health and Related Research Technology Appraisal Group (ScHARR-TAG) at the University of Sheffield was commissioned to act as the independent evidence review group (ERG). The ERG produced a review of the evidence for the clinical and cost effectiveness of mepolizumab as add-on to standard of care (SoC) compared with SoC and omalizumab, based upon the company's submission to NICE...
September 20, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28932340/contact-lenses-for-keratoconus-current-practice
#11
Marilita M Moschos, Eirini Nitoda, Panagiotis Georgoudis, Miltos Balidis, Eleftherios Karageorgiadis, Nikos Kozeis
BACKGROUND: Keratoconus is a chronic, bilateral, usuallly asymmetrical, non-inflammatory, ectatic disorder, being characterized by progressive steepening, thinning and apical scarring of the cornea. Initially, the patient is asymptomatic, but the visual acuity gradually decreases, resulting in significant vision loss due to the development of irregular astigmatism, myopia, corneal thinning and scarring. The classic treatment of visual rehabilitation in keratoconus is based on spectacles and contact lenses (CLs)...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28932106/out-of-pocket-costs-and-adherence-to-antihypertensive-agents-among-older-adults-covered-by-the-public-drug-insurance-plan-in-quebec
#12
Raymond Milan, Helen-Maria Vasiliadis, Samantha Gontijo Guerra, Djamal Berbiche
OBJECTIVE: To evaluate the effect of patient out-of-pocket costs on adherence to antihypertensive agents (AHA) in community-dwelling older adults covered by the public drug insurance plan in Quebec. METHODS: This is a secondary analysis of data from the "Étude sur la santé des aînés" study (2005-2008) on community-dwelling older adults in Quebec aged 65 years and older (N=2,811). The final sample included 881 participants diagnosed with arterial hypertension and treated with AHA...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28929899/nutrition-as-a-component-of-dementia-risk-reduction-strategies
#13
Carol E Greenwood, Matthew D Parrott
According to the Alzheimer Society of Canada, within the next generation, Canada will experience a more than doubling of individuals living with dementia and a potentially economically crippling 10-fold increase in costs to Canadians. Up to 50% of cases with dementia can be attributed to seven modifiable, predominantly vascular and/or lifestyle-associated, risk factors. Multi-modal dementia risk reduction strategies, targeting diet, exercise, mental stimulation, and vascular risk monitoring, are likely to be the most successful...
January 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28929886/water-recycling-at-the-nova-scotia-hospital-central-laundry
#14
David Bligh, Dylan Dingwell
A water recycling system was installed at the Nova Scotia Hospital Central Laundry in Dartmouth, Nova Scotia in the spring of 2014. The consequent reductions in the consumption of water and steam at this facility have been measured over a 20-month period and are presented here in nominal units and as a financial analysis. Cumulative savings over this period have been calculated to be $351,567, representing a 53% annual return on investment after accounting for annual operating and maintenance costs.
March 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28929769/design-and-solidification-of-fast-releasing-clofazimine-nanoparticles-for-treatment-of-cryptosporidiosis
#15
Yingyue Zhang, Jie Feng, Simon A McManus, Hoang D Lu, Kurt D Ristroph, Eugene J Cho, Ellen L Dobrijevic, Hak-Kim Chan, Robert K Prud'homme
Clofazimine, a lipophilic (log P = 7.66) riminophenazine antibiotic approved by the US Food and Drug Administration (FDA) with a good safety record, was recently identified as a lead hit for cryptosporidiosis through a high-throughput phenotypic screen. Cryptosporidiosis requires fast-acting treatment as it leads to severe symptoms which, if untreated, result in morbidity for infants and small children. Consequently, a fast-releasing oral formulation of clofazimine in a water-dispersible form for pediatric administration is highly desirable...
September 20, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28929297/discontinuous-permeable-adsorptive-barrier-design-and-cost-analysis-a-methodological-approach-to-optimisation
#16
Giovanni Francesco Santonastaso, Immacolata Bortone, Simeone Chianese, Armando Di Nardo, Michele Di Natale, Alessandro Erto, Despina Karatza, Dino Musmarra
The following paper presents a method to optimise a discontinuous permeable adsorptive barrier (PAB-D). This method is based on the comparison of different PAB-D configurations obtained by changing some of the main PAB-D design parameters. In particular, the well diameters, the distance between two consecutive passive wells and the distance between two consecutive well lines were varied, and a cost analysis for each configuration was carried out in order to define the best performing and most cost-effective PAB-D configuration...
September 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28929170/comparison-of-two-6-minute-walk-tests-to-assess-walking-capacity-in-polio-survivors
#17
Merel-Anne Brehm, Suzan Verduijn, Jurgen Bon, Nicoline Bredt, Frans Nollet
OBJECTIVE: To compare walking dynamics and test-retest reliability for 2 frequently applied walk tests in polio survivors: the 6-minute walk test (6MWT) to walk as far as possible; and the 6-minute walking energy cost test (WECT) at comfortable speed. DESIGN: Observational study. PARTICIPANTS: Thirty-three polio survivors, able to walk ≥ 150 m. METHODS: On the same day participants performed a 6MWT and a WECT, which were repeated 1-3 weeks later...
September 20, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28929051/comparison-of-effectiveness-of-calendula-officinalis-extract-gel-with-lycopene-gel-for-treatment-of-tobacco-induced-homogeneous-leukoplakia-a-randomized-clinical-trial
#18
Manisha Singh, Anjana Bagewadi
AIM: The aim of the study is to assess the efficacy of Calendula officinalis gel as cost-effective treatment modality in comparison to lycopene gel in the treatment of leukoplakia. MATERIALS AND METHODS: The study comprised of sixty patients of clinically diagnosed and histopathologically confirmed cases of homogeneous leukoplakia which were divided into Group I and Group II with thirty patients each. Group I patients were dispensed C. officinalis extract gel whereas Group II patients were given lycopene gel...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28928111/personalized-hypertension-management-using-patient-generated-health-data-integrated-with-electronic-health-records-empower-h-six-month-pre-post-study
#19
Nan Lv, Lan Xiao, Martha L Simmons, Lisa G Rosas, Albert Chan, Martin Entwistle
BACKGROUND: EMPOWER-H (Engaging and Motivating Patients Online With Enhanced Resources-Hypertension) is a personalized-care model facilitating engagement in hypertension self-management utilizing an interactive Web-based disease management system integrated with the electronic health record. The model is designed to support timely patient-provider interaction by incorporating decision support technology to individualize care and provide personalized feedback for patients with chronic disease...
September 19, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28927978/approaching-zero-implications-of-a-computed-tomography-reduction-program-for-pediatric-appendicitis-evaluation
#20
K Tinsley Anderson, Marisa Bartz-Kurycki, Mary T Austin, Akemi Kawaguchi, Susan D John, Lillian S Kao, KuoJen Tsao
PURPOSE: Because of awareness of iatrogenic radiation exposure, there is a national trend of diminishing computed tomography (CT) use for pediatric suspected appendicitis. The purpose of this study was to evaluate the effects of a CT reduction program for evaluation of appendicitis. METHODS: A multidisciplinary group (emergency medicine, radiology, and surgery) at a children's hospital developed a reduction program which included: ultrasound (U/S) first (2012), magnetic resonance imaging (MRI) second (2014), and standardized U/S reports (2016)...
September 5, 2017: Journal of Pediatric Surgery
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