I L Haeusler, O Daniel, C Isitt, R Watts, L Cantrell, S Feng, M Cochet, M Salloum, S Ikram, E Hayter, S Lim, T Hall, S Athaide, C A Cosgrove, J S Tregoning, K Le Doare
Group B Streptococcus (GBS) is a leading cause of adverse pregnancy outcomes due to invasive infection. This study investigated longitudinal variation in GBS rectovaginal colonisation, serum and vaginal GBS capsular polysaccharide (CPS)-specific antibody levels. Non-pregnant women were recruited in the UK, and were sampled every two weeks over a 12-week period. GBS isolates were taken from recto-vaginal swabs and serotyped by polymerase chain reaction. Serum and vaginal immunoglobulin G (IgG) and nasal immunoglobulin A (IgA) specific to CPS were measured by Luminex, and total IgG/A by ELISA...
July 8, 2022: Clinical and Experimental Immunology