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https://www.readbyqxmd.com/read/29453695/temporary-assist-device-support-for-the-right-ventricle-pre-implant-and-post-implant-challenges
#1
REVIEW
Michael Dandel, Roland Hetzer
Severe right ventricular (RV) failure is more likely reversible than similar magnitudes of left ventricular (LV) failure and, because reversal of both adaptive remodeling and impaired contractility require most often only short periods of support, the use of temporary RV assist devices (t-RVADs) can be a life-saving therapy option for many patients. Although increased experience with t-RVADs and progresses made in the development of safer devices with lower risk for complications has improved both recovery rate of RV function and patient survival, the mortality of t-RVAD recipients can still be high but it depends mainly on the primary cause of RV failure (RVF), the severity of end-organ dysfunction, and the timing of RVAD implantation, and much less on adverse events and complications related to RVAD implantation, support, or removal...
February 17, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29396208/the-impact-of-perceptual-changes-to-studied-items-on-erp-correlates-of-familiarity-and-recollection-is-subject-to-hemispheric-asymmetries
#2
Kristina Küper, Hubert D Zimmer
It is still unclear which role the right hemisphere (RH) preference for perceptually specific and the left hemisphere (LH) bias towards abstract memory representations play at the level of episodic memory retrieval. When stimulus characteristics hampered the retrieval of abstract memory representations, these hemispheric asymmetries have previously only modulated event-related potential (ERP) correlates of recollection (late positive complex, LPC), but not of familiarity (FN400). In the present experiment, we used stimuli which facilitated the retrieval of abstract memory representations...
January 19, 2018: Brain and Cognition
https://www.readbyqxmd.com/read/29393391/stage%C3%A2-dependent-changes-of-%C3%AE-2%C3%A2-adrenergic-receptor-signaling-in-right-ventricular-remodeling-in-monocrotaline%C3%A2-induced-pulmonary-arterial-hypertension
#3
Fengjiao Sun, Zhiqiang Lu, Yidan Zhang, Shihan Geng, Mengxi Xu, Liman Xu, Yingying Huang, Pengwei Zhuang, Yanjun Zhang
Right ventricular (RV) remodeling coupled with extensive apoptosis in response to unrestrained biomechanical stress may lead to RV failure (RVF), which is the immediate cause of death in the majority of patients with pulmonary arterial hypertension (PAH). Overexpression of β2‑adrenergic receptor (β2‑AR) signaling has been reported to induce myocardiotoxicity in patients with left heart failure. However, the role of β2‑AR signaling in the pathophysiology of PAH development has remained elusive. To address this issue, the present study investigated the changes in cardiopulmonary function and structure, as well as the expression of regulators of fibrosis and apoptosis in RVF following monocrotaline (MCT; 60 mg/kg, i...
February 1, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29391128/rift-valley-fever-in-egypt-and-other-african-countries-historical-review-recent-outbreaks-and-possibility-of-disease-occurrence-in-egypt
#4
REVIEW
Mohamed A Kenawy, Yousrya M Abdel-Hamid, John C Beier
This article reviews and discusses the historical and recent status of Rift Valley Fever (RVF) in Egypt and the other African countries based on the available and scattered reports. The recent outbreaks in African countries were reviewed and mapped out. Four major epidemics have been recorded in Egypt (1977, 1978, 1993 and 2003). The outbreak resulted in unpredicted human disease with severe clinical manifestations and heavy mortality as well as many abortions and deaths in sheep, goats, cattle, water buffalo and camels...
January 31, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29370905/right-ventricular-involution-what-can-we-learn-from-nature-s-model-of-compensated-hypertrophy
#5
Megan E Bowen, Xiaoqing Liu, Peter M Sundwall, Stavros G Drakos, Dean Y Li, Craig H Selzman, Stephen H McKellar
BACKGROUND: Right ventricular (RV) failure (RVF) is a vexing problem facing patients with various disease processes and carries a high mortality. RVF is a poorly understood phenomenon with limited treatment options. In mammalian fetal circulation, the right ventricle is the systemic ventricle. In neonates, however, the left ventricle assumes that role and gradually thickens compared with the right ventricle. This process, known as right ventricular involution (RVI), is poorly understood...
December 19, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29367547/the-dark-side-of-the-moon-the-right-ventricle
#6
REVIEW
Massimiliano Foschi, Michele Di Mauro, Fabrizio Tancredi, Carlo Capparuccia, Renata Petroni, Luigi Leonzio, Silvio Romano, Sabina Gallina, Maria Penco, Mario Cibelli, Antonio Calafiore
The aim of this review article is to summarize current knowledge of the pathophysiology underlying right ventricular failure (RVF), focusing, in particular, on right ventricular assessment and prognosis. The right ventricle (RV) can tolerate volume overload well, but is not able to sustain pressure overload. Right ventricular hypertrophy (RVH), as a response to increased afterload, can be adaptive or maladaptive. The easiest and most common way to assess the RV is by two-dimensional (2D) trans-thoracic echocardiography measuring surrogate indexes, such as tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), and tissue Doppler velocity of the lateral aspect of the tricuspid valvular plane...
October 20, 2017: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29366750/defining-the-molecular-signatures-of-human-right-heart-failure
#7
Jordan L Williams, Omer Cavus, Emefah C Loccoh, Sara Adelman, John C Daugherty, Sakima A Smith, Benjamin Canan, Paul M L Janssen, Sara Koenig, Crystal F Kline, Peter J Mohler, Elisa A Bradley
AIMS: Right ventricular failure (RVF) varies significantly from the more common left ventricular failure (LVF). This study was undertaken to determine potential molecular pathways that are important in human right ventricular (RV) function and may mediate RVF. MATERIALS AND METHODS: We analyzed mRNA of human non-failing LV and RV samples and RVF samples from patients with pulmonary arterial hypertension (PAH), and post-LVAD implantation. We then performed transcript analysis to determine differential expression of genes in the human heart samples...
January 20, 2018: Life Sciences
https://www.readbyqxmd.com/read/29363462/seroprevalence-of-rift-valley-fever-virus-antibodies-in-cattle-in-mali-2005-2014
#8
Sonu Subudhi, Martin Dakouo, Angela Sloan, Derek R Stein, Allen Grolla, Shane Jones, Antonia Dibernardo, Kyle Rosenke, Miriam Sas, Abdalah Traore, Robbin Lindsay, Martin H Groschup, Vikram Misra, Heinz Feldmann, Nafomon Sogoba, David Safronetz, Mamadou Niang
Rift Valley fever virus (RVFV) outbreaks have considerable impact on human and animal health. Here, we are reporting a serosurvey of cattle from all regions of Mali. These demonstrated that few had been exposed to RVFV from 2005 to 2014. Recent outbreaks of RVF in Niger and a single human case in Mali provide justification for further entomological and ecological studies of this virus.
January 22, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29360066/perkat%C3%A2-rv-first-in-vivo-data-of-a-novel-right-heart-assist-device
#9
Daniel Kretzschmar, Alexander Lauten, Harald Schubert, Sabine Bischoff, Christian Schulze, Markus W Ferrari
AIMS: Mechanical right ventricular (RV) support offers a treatment option for critically ill patients with RV failure (RVF). We developed an assist device for rapid percutaneous implantation. METHODS AND RESULTS: The PERKAT® RV ("PERkutane KATheterpumptechnologie") device consists of a nitinol chamber covered by foils containing inflow valves. An outlet tube is attached to its distal part. The system is designed for 18F percutaneous implantation. The chamber is unfolded in the inferior vena cava while the outlet tube bypasses the right heart with the tip in the pulmonary trunk...
January 23, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29351273/understanding-the-legal-trade-of-cattle-and-camels-and-the-derived-risk-of-rift-valley-fever-introduction-into-and-transmission-within-egypt
#10
Sebastian Napp, Veronique Chevalier, Núria Busquets, Paolo Calistri, Jordi Casal, Mohamed Attia, Rehab Elbassal, Heba Hosni, Hatem Farrag, Noura Hassan, Rasha Tawfik, Sohair Abd Elkader, Shahin Bayomy
Rift Valley Fever (RVF) is a mosquito-borne zoonosis, which may cause significant losses for the livestock sector and have serious public health implications. Egypt has been repeatedly affected by RVF epidemics, mainly associated to the importation of animals from sub-Saharan countries, where the disease is endemic. The objective of our study was the improvement of the surveillance and control strategies implemented in Egypt. In order to do that, first we evaluated the legal trade of live animals into and within Egypt...
January 19, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29276743/datasets-for-mapping-pastoralist-movement-patterns-and-risk-zones-of-rift-valley-fever-occurrence
#11
Gladys Mosomtai, Magnus Evander, Charles Mundia, Per Sandström, Clas Ahlm, Osama Ahmed Hassan, Olivia Wesula Lwande, Moses K Gachari, Tobias Landmann, Rosemary Sang
Rift Valley fever (RVF) is a zoonotic disease affecting humans and animals. It is caused by RVF virus transmitted primarily by Aedes mosquitoes. The data presented in this article propose environmental layers suitable for mapping RVF vector habitat zones and livestock migratory routes. Using species distribution modelling, we used RVF vector occurrence data sampled along livestock migratory routes to identify suitable vector habitats within the study region which is located in the central and the north-eastern part of Kenya...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29210774/liberal-right-ventricular-assist-device-extracorporeal-membrane-oxygenation-support-for-right-ventricular-failure-after-implantable-left-ventricular-assist-device-placement
#12
Quentin Fischer, Matthias Kirsch
Refractory right ventricular failure (RVF) after implantation of left ventricular assist device (LVAD) is a dramatic complication. The addition of right ventricular assist device (RVAD) may improve RV recovery and lead to improve outcomes. From February 2012 to September 2014, 44 patients received a HeartMate II. These patients were retrospectively compared in two groups according to early liberal implantation of an extracorporeal membrane oxygenation (ECMO) used as a RVAD established between a femoral vein and the pulmonary artery...
November 27, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29196275/global-risk-mapping-for-major-diseases-transmitted-by-aedes-aegypti-and-aedes-albopictus
#13
Samson Leta, Tariku Jibat Beyene, Eva M De Clercq, Kebede Amenu, Crawford Revie
OBJECTIVES: The objective of this study was to map the global risk of the major arboviral diseases transmitted by Aedes aegypti and Ae. albopictus by identifying areas where the diseases are reported either through active transmission or travel related outbreaks, as well as areas where the diseases are not currently reported but are nonetheless suitable for the vector. METHODS: This study extracts data from some of the largest contemporary databases relating to five arboviral diseases (Zika, dengue fever, chikungunya, yellow fever and RVF) and pairs these data with the known distribution of their vectors, Ae...
November 28, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29172742/the-risk-of-right-ventricular-failure-with-current-continuous-flow-left-ventricular-assist-devices
#14
Antonio Loforte, Francesco Grigioni, Giuseppe Marinelli
Right ventricular failure (RVF) still results as the major cause of morbidity and mortality after left ventricular assist device (LVAD) implantation. Despite overall improved outcomes and lower rates of RVF with the use of the newer, continuous-flow (CF) LVADs over pulsatile-flow devices, and development of clinical prediction scores to facilitate preoperative identification of patients at risk for RVF after implantation, RVF occurs in 13% to 40% of continuous-flow device. Areas covered: In this article, a review has been carried out on the current evidence for preoperative assessment of RV function and RVF risk for appropriate patient selection mainly focusing on current imaging and invasive assessment tools...
November 25, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29167748/genetic-stability-of-rift-valley-fever-virus-mp-12-vaccine-during-serial-passages-in-culture-cells
#15
Nandadeva Lokugamage, Tetsuro Ikegami
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa which affects both ruminants and humans. RVF causes serious damage to the livestock industry and is also a threat to public health. The Rift Valley fever virus has a segmented negative-stranded RNA genome consisting of Large (L)-, Medium (M)-, and Small (S)-segments. The live-attenuated MP-12 vaccine is immunogenic in livestock and humans, and is conditionally licensed for veterinary use in the U.S. The MP-12 strain encodes 23 mutations (nine amino acid substitutions) and is attenuated through a combination of mutations in the L-, M-, and S-segments...
2017: NPJ Vaccines
https://www.readbyqxmd.com/read/29151490/ppar%C3%AE-alleviates-right-ventricular-failure-secondary-to-pulmonary-arterial-hypertension-in-rats
#16
Ying Xu, Qin Gu, Ning Liu, Yan Yan, Xilan Yang, Yingying Hao, Chen Qu
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling leading to right ventricular hypertrophy (RVH) and failure. Peroxisome proliferator-activated receptor γ (PPARγ), a member of nuclear receptors, has been proved to ameliorate PAH. However, its effect on PAH-induced right ventricular failure (RVF) remains unknown. Therefore, we investigated the therapeutic potential of PPARγ in preventing monocrotaline (MCT) -induced RV dysfunction. The PAH model was induced by MCT administration...
November 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29145262/management-of-radiation-induced-rectovesical-fistula-in-a-woman-using-ileum-a-case-report-and-review-of-the-literature
#17
Qiqi Mao, Jindan Luo, Jiajie Fang, Hai Jiang
BACKGROUND: Radiation-induced rectovesical fistulas (RVFs) require the most demanding treatment. We presented a rare case of postradiation RVF in a woman repaired with ileum. CASE PRESENTATION: A 49-year-old women was referred to our department for fecaluria and dysuria after radiation for cervical cancer. The voiding cystourethrography demonstrated a large RVF. A segment of ileum was separated into 2 parts for the simultaneous reconstruction of bladder and rectum, which led to a permanently closed fistula...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29141494/influence-of-script-direction-on-word-processing-modes-in-left-and-right-visual-fields
#18
Eric Siéroff, Yael Slama
Word processing in left (LVF) and right (RVF) visual fields may be affected by left hemisphere activation during reading and by script direction. We evaluated the effect of script direction by presenting words in left-to-right (French) and right-to-left (Hebrew) scripts to bilingual French participants. Words of different lengths were presented in the LVF and the RVF in a naming task. Results showed (1) a stronger word length effect in the LVF than in the RVF in French, and no difference of word length effect between LVF and RVF in Hebrew; (2) a first-letter advantage only in the LVF in French and in the RVF in Hebrew, showing an effect of script direction on letter processing; and (3) a stronger advantage of external over internal letters in words presented in the LVF than in the RVF for both languages, showing a left hemisphere influence on letter activation...
November 15, 2017: Laterality
https://www.readbyqxmd.com/read/29126956/effect-of-graduated-compression-stockings-on-venous-lower-limb-hemodynamics-in-healthy-amateur-runners
#19
Oswaldo Teno Castilho Junior, Nei Rodrigues Alves Dezotti, Marcelo Bellini Dalio, Edwaldo Edner Joviliano, Carlos Eli Piccinato
OBJECTIVE: The objective of this study was to analyze the effect of graduated compression stockings (GCS) on venous lower limb hemodynamics in healthy amateur runners. METHODS: Ten runners were evaluated during rest and after a 10-km run without and with knee-high GCS of 20 to 30 mm Hg. Air plethysmography evaluated venous filling index (VFI), ejection fraction, and residual volume fraction (RVF) in both limbs. Capillary lactate level and heart rate were also measured...
November 7, 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29118127/peripheral-blood-biomarkers-of-disease-outcome-in-a-monkey-model-of-rift-valley-fever-encephalitis
#20
Elizabeth R Wonderlich, Amy L Caroline, Cynthia M McMillen, Aaron W Walters, Douglas S Reed, Simon M Barratt-Boyes, Amy L Hartman
Rift Valley Fever (RVF) is an emerging arboviral disease of livestock and people. Although a mosquito-borne virus, humans are infected through contact with or inhalation of virus-laden particles from contaminated animal carcasses. Some individuals infected with RVF virus (RVFV) develop meningoencephalitis resulting in morbidity and mortality. Little is known about the pathogenic mechanisms that lead to neurologic sequelae, and thus animal models that represent human disease are needed. African green monkeys (AGM) exposed to aerosols containing RVFV develop a reproducibly lethal neurological disease that resembles human illness...
November 8, 2017: Journal of Virology
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