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https://www.readbyqxmd.com/read/29652643/expression-of-a-recombinant-nucleocapsid-protein-of-rift-valley-fever-virus-in-vero-cells-as-an-immunofluorescence-antigen-and-its-use-for-serosurveillance-in-traditional-cattle-herds-in-zambia
#1
Ngonda Saasa, Masahiro Kajihara, George Dautu, Akina Mori-Kajihara, Shuetsu Fukushi, Yona Sinkala, Shigeru Morikawa, Aaron Mweene, Ayato Takada, Kumiko Yoshimatsu, Jiro Arikawa
The open reading frame of the nucleocapsid protein (NP) of Rift Valley fever virus (RVFV) strain MP12 was cloned and expressed in Vero E6 cells. The recombinant NP (rNP)-expressing cells were used as antigens for an indirect immunofluorescent antibody assay (IFA). The rNP-based IFA and RVFV-infected Vero E6 cell (authentic antigen)-based IFA showed similar IFA profiles with immune rabbit serum, which was prepared by immunization with rNP expressed using a baculovirus vector. A total of 942 traditional cattle sera obtained in five districts in Central, Southern, and Western provinces of Zambia were screened for anti-RVFV antibodies by the authentic antigen-based and rNP-based IFAs...
March 13, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29629994/the-achilles-heel-of-left-ventricular-assist-device-therapy-right-ventricle
#2
Neel K Ranganath, Deane E Smith, Nader Moazami
PURPOSE OF REVIEW: Many patients suffer from either persistent right ventricular failure (RVF) at the time of left ventricular assist device (LVAD) or have ongoing symptoms consistent with RVF during chronic mechanical circulatory support. The lack of long-term right ventricular assist devices (RVADs) has limited the impact that mechanical circulatory support can provide to patients with biventricular failure. We aim to review the entire spectrum of RVF in patients receiving LVADs and reflect on why this entity remains the Achilles' heel of LVAD therapy...
April 7, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29614252/hemispheric-processing-in-conventional-metaphor-comprehension-the-role-of-general-knowledge
#3
Stephen W Briner, Michael C Schutzenhofer, Sandra M Virtue
This study explored the relation between general knowledge and the hemispheric processing of metaphoric expressions in college age students. We hypothesized that prior knowledge influences how the hemispheres process metaphors in these individuals. In this study, 97 young (college-aged) adults completed a general knowledge and vocabulary test, and were then divided into high-knowledge/high-vocabulary and low-knowledge/low-vocabulary groups. Next, participants viewed word pairs consisting of conventional metaphors, novel metaphors, word pairs with a literal meaning, and unrelated word pairs...
March 31, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29603042/a-transvaginal-approach-to-rectovaginal-fistulae-for-the-colorectal-surgeon-technical-notes-and-case-series
#4
R Bhome, A Monga, K P Nugent
Rectovaginal fistulae (RVF) are not uncommonly seen by the colorectal surgeon and gynaecologist, often debilitating for patients and typically managed with multiple operative procedures, achieving control rather than cure. Transvaginal repair is the least common surgical approach but has clear advantages and equivalent healing rates to other approaches. Here, we describe a simple, safe and effective flapless transvaginal technique for the repair of primary and recurrent low- and mid-level RVF of varying aetiology...
March 30, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29514112/rift-valley-fever-vaccines-current-and-future-needs
#5
REVIEW
Baptiste Dungu, Baratang A Lubisi, Tetsuro Ikegami
Rift Valley fever (RVF) is a zoonotic mosquito-borne bunyaviral disease associated with high abortion rates, neonatal deaths, and fetal malformations in ruminants, and mild to severe disease in humans. Outbreaks of RVF cause huge economic losses and public health impacts in endemic countries in Africa and the Arabian Peninsula. A proper vaccination strategy is important for preventing or minimizing outbreaks. Vaccination against RVF is not practiced in many countries, however, due to absence or irregular occurrences of outbreaks, despite serological evidence of RVF viral activity...
March 4, 2018: Current Opinion in Virology
https://www.readbyqxmd.com/read/29511676/effect-of-riociguat-and-sildenafil-on-right-heart-remodeling-and-function-in-pressure-overload-induced-model-of-pulmonary-arterial-banding
#6
Nabham Rai, Swathi Veeroju, Yves Schymura, Wiebke Janssen, Astrid Wietelmann, Baktybek Kojonazarov, Norbert Weissmann, Johannes-Peter Stasch, Hossein Ardeschir Ghofrani, Werner Seeger, Ralph Theo Schermuly, Tatyana Novoyatleva
Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by remodeling of the pulmonary vasculature and a rise in right ventricular (RV) afterload. The increased RV afterload leads to right ventricular failure (RVF) which is the reason for the high morbidity and mortality in PAH patients. The objective was to evaluate the therapeutic efficacy and antiremodeling potential of the phosphodiesterase type 5 (PDE5) inhibitor sildenafil and the soluble guanylate cyclase stimulator riociguat in a model of pressure overload RV hypertrophy induced by pulmonary artery banding (PAB)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29511136/one-or-two-stages-procedure-for-repair-of-rectovestibular-fistula-which-is-safer-a-single-institution-experience
#7
Mohammed Khalifa, Khalid Shreef, Mohammad Ahmad Al Ekrashy, Tarek Abdelazim Gobran
Background: Rectovestibular fistula (RVF) is the most common type of anorectal malformations in females. The need for a diverting colostomy during correction of defect has ignited a heated debate. In this study, we reviewed the girls with RVF that had been treated by either one or two stage procedure in the past 10 years in our institution to define whether one stage or two stage procedures is safer and more beneficial for the patients. Materials and Methods: Seventy girls with RVF that had been operated from January 2005 to January 2015 were studied retrospectively...
April 2017: African Journal of Paediatric Surgery: AJPS
https://www.readbyqxmd.com/read/29505579/rift-valley-fever-a-survey-of-knowledge-attitudes-and-practice-of-slaughterhouse-workers-and-community-members-in-kabale-district-uganda
#8
Annabelle de St Maurice, Luke Nyakarahuka, Lawrence Purpura, Elizabeth Ervin, Alex Tumusiime, Stephen Balinandi, Jackson Kyondo, Sophia Mulei, Patrick Tusiime, Craig Manning, Pierre E Rollin, Barbara Knust, Trevor Shoemaker
BACKGROUND: Rift Valley Fever virus (RVF) is a zoonotic virus in the Phenuiviridae family. RVF outbreaks can cause significant morbidity and mortality in humans and animals. Following the diagnosis of two RVF cases in March 2016 in southern Kabale district, Uganda, we conducted a knowledge, attitudes and practice (KAP) survey to identify knowledge gaps and at-risk behaviors related to RVF. METHODOLOGY/PRINCIPAL FINDINGS: A multidisciplinary team interviewed 657 community members, including abattoir workers, in and around Kabale District, Uganda...
March 5, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29462214/a-phytosociological-analysis-and-description-of-wetland-vegetation-and-ecological-factors-associated-with-locations-of-high-mortality-for-the-2010-11-rift-valley-fever-outbreak-in-south-africa
#9
Robert F Brand, Melinda K Rostal, Alan Kemp, Assaf Anyamba, Herman Zwiegers, Cornelius W Van Huyssteen, William B Karesh, Janusz T Paweska
Rift Valley fever (RVF) is endemic in Africa and parts of the Middle East. It is an emerging zoonotic disease threat to veterinary and public health. Outbreaks of the disease have severe socio-economic impacts. RVF virus emergence is closely associated with specific endorheic wetlands that are utilized by the virus' mosquito vectors. Limited botanical vegetation surveys had been published with regard to RVF virus (RVFV) ecology. We report on a phytosociological classification, analysis and description of wetland vegetation and related abiotic parameters to elucidate factors possibly associated with the 2010-2011 RVFV disease outbreak in South Africa...
2018: PloS One
https://www.readbyqxmd.com/read/29460865/the-first-positive-serological-study-on-rift-valley-fever-in-ruminants-of-iran
#10
Shahin Fakour, Salahedin Naserabadi, Elham Ahmadi
Background & objectives: Rift Valley fever (RVF) is a zoonotic vector-borne disease that primarily affects domestic animals but can also infect humans. The purpose of the present study was to investigate the presence of antibodies against RVF virus (RVFV) in ruminants, viz. cattle, sheep, and goats in Kurdistan Province of western Iran. Methods: Blood samples were collected from 288 ruminants (118 cattle, 142 sheep and 28 goats) of both sexes, under age groups ≤1, 1-3, 3-5 and ≥5 yr, from January 2016 to December 2016...
October 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29453695/temporary-assist-device-support-for-the-right-ventricle-pre-implant-and-post-implant-challenges
#11
REVIEW
Michael Dandel, Roland Hetzer
Severe right ventricular (RV) failure is more likely reversible than similar magnitudes of left ventricular (LV) failure and, because reversal of both adaptive remodeling and impaired contractility require most often only short periods of support, the use of temporary RV assist devices (t-RVADs) can be a life-saving therapy option for many patients. Although increased experience with t-RVADs and progresses made in the development of safer devices with lower risk for complications has improved both recovery rate of RV function and patient survival, the mortality of t-RVAD recipients can still be high but it depends mainly on the primary cause of RV failure (RVF), the severity of end-organ dysfunction, and the timing of RVAD implantation, and much less on adverse events and complications related to RVAD implantation, support, or removal...
February 17, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29396208/the-impact-of-perceptual-changes-to-studied-items-on-erp-correlates-of-familiarity-and-recollection-is-subject-to-hemispheric-asymmetries
#12
Kristina Küper, Hubert D Zimmer
It is still unclear which role the right hemisphere (RH) preference for perceptually specific and the left hemisphere (LH) bias towards abstract memory representations play at the level of episodic memory retrieval. When stimulus characteristics hampered the retrieval of abstract memory representations, these hemispheric asymmetries have previously only modulated event-related potential (ERP) correlates of recollection (late positive complex, LPC), but not of familiarity (FN400). In the present experiment, we used stimuli which facilitated the retrieval of abstract memory representations...
January 19, 2018: Brain and Cognition
https://www.readbyqxmd.com/read/29393391/stage%C3%A2-dependent-changes-of-%C3%AE-2%C3%A2-adrenergic-receptor-signaling-in-right-ventricular-remodeling-in-monocrotaline%C3%A2-induced-pulmonary-arterial-hypertension
#13
Fengjiao Sun, Zhiqiang Lu, Yidan Zhang, Shihan Geng, Mengxi Xu, Liman Xu, Yingying Huang, Pengwei Zhuang, Yanjun Zhang
Right ventricular (RV) remodeling coupled with extensive apoptosis in response to unrestrained biomechanical stress may lead to RV failure (RVF), which is the immediate cause of death in the majority of patients with pulmonary arterial hypertension (PAH). Overexpression of β2‑adrenergic receptor (β2‑AR) signaling has been reported to induce myocardiotoxicity in patients with left heart failure. However, the role of β2‑AR signaling in the pathophysiology of PAH development has remained elusive. To address this issue, the present study investigated the changes in cardiopulmonary function and structure, as well as the expression of regulators of fibrosis and apoptosis in RVF following monocrotaline (MCT; 60 mg/kg, i...
February 1, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29391128/rift-valley-fever-in-egypt-and-other-african-countries-historical-review-recent-outbreaks-and-possibility-of-disease-occurrence-in-egypt
#14
REVIEW
Mohamed A Kenawy, Yousrya M Abdel-Hamid, John C Beier
This article reviews and discusses the historical and recent status of Rift Valley Fever (RVF) in Egypt and the other African countries based on the available and scattered reports. The recent outbreaks in African countries were reviewed and mapped out. Four major epidemics have been recorded in Egypt (1977, 1978, 1993 and 2003). The outbreak resulted in unpredicted human disease with severe clinical manifestations and heavy mortality as well as many abortions and deaths in sheep, goats, cattle, water buffalo and camels...
January 31, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29370905/right-ventricular-involution-what-can-we-learn-from-nature-s-model-of-compensated-hypertrophy
#15
Megan E Bowen, Xiaoqing Liu, Peter M Sundwall, Stavros G Drakos, Dean Y Li, Craig H Selzman, Stephen H McKellar
BACKGROUND: Right ventricular (RV) failure (RVF) is a vexing problem facing patients with various disease processes and carries a high mortality. RVF is a poorly understood phenomenon with limited treatment options. In mammalian fetal circulation, the right ventricle is the systemic ventricle. In neonates, however, the left ventricle assumes that role and gradually thickens compared with the right ventricle. This process, known as right ventricular involution (RVI), is poorly understood...
December 19, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29367547/the-dark-side-of-the-moon-the-right-ventricle
#16
REVIEW
Massimiliano Foschi, Michele Di Mauro, Fabrizio Tancredi, Carlo Capparuccia, Renata Petroni, Luigi Leonzio, Silvio Romano, Sabina Gallina, Maria Penco, Mario Cibelli, Antonio Calafiore
The aim of this review article is to summarize current knowledge of the pathophysiology underlying right ventricular failure (RVF), focusing, in particular, on right ventricular assessment and prognosis. The right ventricle (RV) can tolerate volume overload well, but is not able to sustain pressure overload. Right ventricular hypertrophy (RVH), as a response to increased afterload, can be adaptive or maladaptive. The easiest and most common way to assess the RV is by two-dimensional (2D) trans-thoracic echocardiography measuring surrogate indexes, such as tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), and tissue Doppler velocity of the lateral aspect of the tricuspid valvular plane...
October 20, 2017: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29366750/defining-the-molecular-signatures-of-human-right-heart-failure
#17
Jordan L Williams, Omer Cavus, Emefah C Loccoh, Sara Adelman, John C Daugherty, Sakima A Smith, Benjamin Canan, Paul M L Janssen, Sara Koenig, Crystal F Kline, Peter J Mohler, Elisa A Bradley
AIMS: Right ventricular failure (RVF) varies significantly from the more common left ventricular failure (LVF). This study was undertaken to determine potential molecular pathways that are important in human right ventricular (RV) function and may mediate RVF. MATERIALS AND METHODS: We analyzed mRNA of human non-failing LV and RV samples and RVF samples from patients with pulmonary arterial hypertension (PAH), and post-LVAD implantation. We then performed transcript analysis to determine differential expression of genes in the human heart samples...
March 1, 2018: Life Sciences
https://www.readbyqxmd.com/read/29363462/seroprevalence-of-rift-valley-fever-virus-antibodies-in-cattle-in-mali-2005-2014
#18
Sonu Subudhi, Martin Dakouo, Angela Sloan, Derek R Stein, Allen Grolla, Shane Jones, Antonia Dibernardo, Kyle Rosenke, Miriam Sas, Abdalah Traore, Robbin Lindsay, Martin H Groschup, Vikram Misra, Heinz Feldmann, Nafomon Sogoba, David Safronetz, Mamadou Niang
Rift Valley fever virus (RVFV) outbreaks have considerable impact on human and animal health. Here, we are reporting a serosurvey of cattle from all regions of Mali. These demonstrated that few had been exposed to RVFV from 2005 to 2014. Recent outbreaks of RVF in Niger and a single human case in Mali provide justification for further entomological and ecological studies of this virus.
March 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29360066/perkat-rv-first-in-vivo-data-of-a-novel-right-heart-assist-device
#19
Daniel Kretzschmar, Alexander Lauten, Harald Schubert, Sabine Bischoff, Christian Schulze, Markus W Ferrari
AIMS: Mechanical right ventricular (RV) support offers a treatment option for critically ill patients with RV failure (RVF). We developed an assist device for rapid percutaneous implantation. The aim of the present study was to investigate the implantation procedure, haemodynamic performance and possible side effects of the novel right ventricular assist device - PERKAT RV - in an animal model. METHODS AND RESULTS: The PERkutane KATheterpumptechnologie RV (PERKAT RV) device consists of a nitinol chamber covered by foil containing inflow valves...
April 6, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29351273/understanding-the-legal-trade-of-cattle-and-camels-and-the-derived-risk-of-rift-valley-fever-introduction-into-and-transmission-within-egypt
#20
Sebastian Napp, Veronique Chevalier, Núria Busquets, Paolo Calistri, Jordi Casal, Mohamed Attia, Rehab Elbassal, Heba Hosni, Hatem Farrag, Noura Hassan, Rasha Tawfik, Sohair Abd Elkader, Shahin Bayomy
Rift Valley Fever (RVF) is a mosquito-borne zoonosis, which may cause significant losses for the livestock sector and have serious public health implications. Egypt has been repeatedly affected by RVF epidemics, mainly associated to the importation of animals from sub-Saharan countries, where the disease is endemic. The objective of our study was the improvement of the surveillance and control strategies implemented in Egypt. In order to do that, first we evaluated the legal trade of live animals into and within Egypt...
January 2018: PLoS Neglected Tropical Diseases
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