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dementia pugilistica

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https://www.readbyqxmd.com/read/27395469/-late-onset-neurodegenerative-diseases-following-traumatic-brain-injury-chronic-traumatic-encephalopathy-cte-and-alzheimer-s-disease-secondary-to-tbi-ad-tbi
#1
Keisuke Takahata, Hajime Tabuchi, Masaru Mimura
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease, which is associated with mild repetitive traumatic brain injury (TBI). This long-term and progressive symptom due to TBI was initially called punch-drunk syndrome or dementia pugilistica, since it was believed to be associated with boxing. However, serial neuropathological studies of mild repetitive TBI in the last decade have revealed that CTE occurs not only in boxers but also in a wider population including American football players, wrestlers, and military personnel...
July 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/27021775/chronic-traumatic-encephalopathy-and-movement-disorders-update
#2
REVIEW
Apameh Tarazi, Charles H Tator, Maria Carmela Tartaglia
Association of repetitive brain trauma with progressive neurological deterioration has been described since the 1920s. Punch drunk syndrome and dementia pugilistica (DP) were introduced first to explain symptoms in boxers, and more recently, chronic traumatic encephalopathy (CTE) has been used to describe a neurodegenerative disease in athletes and military personal with a history of multiple concussions. Although there are many similarities between DP and CTE, a number of key differences are apparent especially when comparing movement impairments...
May 2016: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/26772317/chronic-traumatic-encephalopathy-the-neuropathological-legacy-of-traumatic-brain-injury
#3
Jennifer Hay, Victoria E Johnson, Douglas H Smith, William Stewart
Almost a century ago, the first clinical account of the punch-drunk syndrome emerged, describing chronic neurological and neuropsychiatric sequelae occurring in former boxers. Thereafter, throughout the twentieth century, further reports added to our understanding of the neuropathological consequences of a career in boxing, leading to descriptions of a distinct neurodegenerative pathology, termed dementia pugilistica. During the past decade, growing recognition of this pathology in autopsy studies of nonboxers who were exposed to repetitive, mild traumatic brain injury, or to a single, moderate or severe traumatic brain injury, has led to an awareness that it is exposure to traumatic brain injury that carries with it a risk of this neurodegenerative disease, not the sport or the circumstance in which the injury is sustained...
May 23, 2016: Annual Review of Pathology
https://www.readbyqxmd.com/read/25933385/chronic-effects-of-mild-neurotrauma-putting-the-cart-before-the-horse
#4
REVIEW
Rudy J Castellani, George Perry, Grant L Iverson
Accumulation of phosphorylated tau (p-tau) is accepted by many as a long-term consequence of repetitive mild neurotrauma based largely on brain findings in boxers (dementia pugilistica) and, more recently, former professional athletes, military service members, and others exposed to repetitive head trauma. The pathogenic construct is also largely accepted and suggests that repetitive head trauma (typically concussions or subconcussive forces) acts on brain parenchyma to produce a deleterious neuroinflammatory cascade, encompassing p-tau templating, transsynaptic neurotoxicity, progressive neurodegenerative disease, and associated clinical features...
June 2015: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/25828776/dementia-pugilistica-a-severe-tribute-to-a-career
#5
Sébastien Lepreux, Sophie Auriacombe, Claude Vital, Bruno Dubois, Anne Vital
A 59-year-old man, ex-professional boxer, met clinical criteria for probable Alzheimer's disease. The patient agreed to be included in a clinico-pathological study with donation to the brain bank, and he died at 71. The brain was grossly atrophic, with a prominent atrophy of the entorhinal cortex and hippocampus, and with pallor of the substantia nigra. Immunohistochemistry with anti-τ A4 revealed abundant and diffuse deposits in the neo-cortex, whereas amyloid angiopathy was absent. Coupled anti-τ AT8 immunohistochemistry and Congo red staining showed no neuritic plaques...
July 2015: Clinical Neuropathology
https://www.readbyqxmd.com/read/25580160/clinical-subtypes-of-chronic-traumatic-encephalopathy-literature-review-and-proposed-research-diagnostic-criteria-for-traumatic-encephalopathy-syndrome
#6
REVIEW
Philip H Montenigro, Christine M Baugh, Daniel H Daneshvar, Jesse Mez, Andrew E Budson, Rhoda Au, Douglas I Katz, Robert C Cantu, Robert A Stern
The long-term consequences of repetitive head impacts have been described since the early 20th century. Terms such as punch drunk and dementia pugilistica were first used to describe the clinical syndromes experienced by boxers. A more generic designation, chronic traumatic encephalopathy (CTE), has been employed since the mid-1900s and has been used in recent years to describe a neurodegenerative disease found not just in boxers but in American football players, other contact sport athletes, military veterans, and others with histories of repetitive brain trauma, including concussions and subconcussive trauma...
2014: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/25421001/chronic-neurodegeneration-after-traumatic-brain-injury-alzheimer-disease-chronic-traumatic-encephalopathy-or-persistent-neuroinflammation
#7
REVIEW
Alan I Faden, David J Loane
It has long been suggested that prior traumatic brain injury (TBI) increases the subsequent incidence of chronic neurodegenerative disorders, including Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis. Among these, the association with Alzheimer disease has the strongest support. There is also a long-recognized association between repeated concussive insults and progressive cognitive decline or other neuropsychiatric abnormalities. The latter was first described in boxers as dementia pugilistica, and has received widespread recent attention in contact sports such as professional American football...
January 2015: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/25231386/chronic-traumatic-encephalopathy-clinical-biomarker-correlations-and-current-concepts-in-pathogenesis
#8
REVIEW
Sam Gandy, Milos D Ikonomovic, Effie Mitsis, Gregory Elder, Stephen T Ahlers, Jeffrey Barth, James R Stone, Steven T DeKosky
BACKGROUND: Chronic traumatic encephalopathy (CTE) is a recently revived term used to describe a neurodegenerative process that occurs as a long term complication of repetitive mild traumatic brain injury (TBI). Corsellis provided one of the classic descriptions of CTE in boxers under the name "dementia pugilistica" (DP). Much recent attention has been drawn to the apparent association of CTE with contact sports (football, soccer, hockey) and with frequent battlefield exposure to blast waves generated by improvised explosive devices (IEDs)...
2014: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/24398724/chronic-neurodegenerative-consequences-of-traumatic-brain-injury
#9
REVIEW
Neelima B Chauhan
Traumatic brain injury (TBI) is a serious public health concern and a major cause of death and disability worldwide. Each year, an estimated 1.7 million Americans sustain TBI of which ~52,000 people die, ~275,000 people are hospitalized and 1,365,000 people are treated as emergency outpatients. Currently there are ~5.3 million Americans living with TBI. TBI is more of a disease process than of an event that is associated with immediate and long-term sensomotor, psychological and cognitive impairments. TBI is the best known established epigenetic risk factor for later development of neurodegenerative diseases and dementia...
2014: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/24264648/modern-chronic-traumatic-encephalopathy-in-retired-athletes-what-is-the-evidence
#10
REVIEW
Stella Karantzoulis, Christopher Randolph
It has been theorized that a career in contact sports may be associated with long-term neurodegenerative changes. This idea dates as far back as the 1920s, was initially reported in boxers, colloquially termed 'punch drunk,' later more formally termed dementia pugilistica (DP), and now coined chronic traumatic encephalopathy (CTE). Despite considerable ongoing interest on this topic, there is so far only limited evidence showing an association between sport-related concussion (SRC) and increased risk for late-life cognitive and neuropsychiatric impairment, with no causality or risk factors yet determined...
December 2013: Neuropsychology Review
https://www.readbyqxmd.com/read/24190181/chronic-traumatic-encephalopathy-a-critical-appraisal
#11
REVIEW
Benjamin Levin, Anish Bhardwaj
Chronic traumatic encephalopathy (CTE) formerly known as dementia pugilistica is a long-term neurodegenerative disorder associated with repeated subconcussive head injuries in high-contact sports. We reviewed the existing literature on CTE and examined epidemiological trends, risk factors, and its temporal progression, and proposed the underlying pathophysiological mechanisms that may provide unique insights to clinicians with an in-depth understanding of the disease to aid in the diagnosis and prevention, and provide future perspectives for research via search of Medline and Cochrane databases as well as manual review of bibliographies from selected articles and monographs...
April 2014: Neurocritical Care
https://www.readbyqxmd.com/read/24136455/chronic-traumatic-encephalopathy-where-are-we-and-where-are-we-going
#12
REVIEW
Jesse Mez, Robert A Stern, Ann C McKee
Chronic traumatic encephalopathy (CTE, previously called punch drunk and dementia pugilistica) has a rich history in the medical literature in association with boxing, but has only recently been recognized with other contact sports, such as football and ice hockey, as well as with military blast injuries. CTE is thought to be a neurodegenerative disease associated with repeated concussive and subconcussive blows to the head. There is characteristic gross and microscopic pathology found in the brain, including frontal and temporal atrophy, axonal degeneration, and hyperphosphorylated tau and TAR DNA-binding protein 43 pathology...
December 2013: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/23702075/mild-head-injury-in-pediatrics-algorithms-for-management-in-the-ed-and-in-young-athletes
#13
REVIEW
Burkhard Simma, Jürg Lütschg, James M Callahan
Mild head injury is of interest because of a history of under diagnosis and underestimated clinical importance. Half of the patients with mild head injuries or concussions have sport-related injuries. Knowledge of symptoms and appropriate management can be improved and is a matter of practical interest. Several algorithms exist for discharge, admission or for cranial computed tomography (CT).These employ different risk factors and calculate their sensitivity of correctly identifying children with traumatic brain injury (TBI)...
July 2013: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/23479493/what-is-the-evidence-for-chronic-concussion-related-changes-in-retired-athletes-behavioural-pathological-and-clinical-outcomes
#14
REVIEW
Paul McCrory, Willem H Meeuwisse, Jeffrey S Kutcher, Barry D Jordan, Andrew Gardner
OBJECTIVE: The purpose of this paper was to review the current state of evidence for chronic traumatic encephalopathy (CTE) in retired athletes and to consider the potential differential diagnoses that require consideration when retired athletes present with cognitive and psychiatric problems. DATA SOURCES: MEDLINE, CINAHL, EMBASE, Mosby's Index, PsycEXTRA, PsycINFO and Scopus. Key words included CTE, dementia pugilistica, punch drunk syndrome, traumatic encephalopathy, CTE, repetitive head injury, sports concussion, multiple concussions, chronic concussions, subconcussive blow and sports-related traumatic brain injury...
April 2013: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/23478462/the-clinical-spectrum-of-sport-related-traumatic-brain-injury
#15
REVIEW
Barry D Jordan
Acute and chronic sports-related traumatic brain injuries (TBIs) are a substantial public health concern. Various types of acute TBI can occur in sport, but detection and management of cerebral concussion is of greatest importance as mismanagement of this syndrome can lead to persistent or chronic postconcussion syndrome (CPCS) or diffuse cerebral swelling. Chronic TBI encompasses a spectrum of disorders that are associated with long-term consequences of brain injury, including chronic traumatic encephalopathy (CTE), dementia pugilistica, post-traumatic parkinsonism, post-traumatic dementia and CPCS...
April 2013: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/23458973/chronic-neuropathologies-of-single-and-repetitive-tbi-substrates-of-dementia
#16
REVIEW
Douglas H Smith, Victoria E Johnson, William Stewart
Traumatic brain injury (TBI) has long been recognized to be a risk factor for dementia. This association has, however, only recently gained widespread attention through the increased awareness of 'chronic traumatic encephalopathy' (CTE) in athletes exposed to repetitive head injury. Originally termed 'dementia pugilistica' and linked to a career in boxing, descriptions of the neuropathological features of CTE include brain atrophy, cavum septum pellucidum, and amyloid-β, tau and TDP-43 pathologies, many of which might contribute to clinical syndromes of cognitive impairment...
April 2013: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/23268705/neurochemical-profile-of-dementia-pugilistica
#17
Tyler A Kokjohn, Chera L Maarouf, Ian D Daugs, Jesse M Hunter, Charisse M Whiteside, Michael Malek-Ahmadi, Emma Rodriguez, Walter Kalback, Sandra A Jacobson, Marwan N Sabbagh, Thomas G Beach, Alex E Roher
Dementia pugilistica (DP), a suite of neuropathological and cognitive function declines after chronic traumatic brain injury (TBI), is present in approximately 20% of retired boxers. Epidemiological studies indicate TBI is a risk factor for neurodegenerative disorders including Alzheimer disease (AD) and Parkinson disease (PD). Some biochemical alterations observed in AD and PD may be recapitulated in DP and other TBI persons. In this report, we investigate long-term biochemical changes in the brains of former boxers with neuropathologically confirmed DP...
June 1, 2013: Journal of Neurotrauma
https://www.readbyqxmd.com/read/23217738/the-neuropathology-and-neurobiology-of-traumatic-brain-injury
#18
REVIEW
Kaj Blennow, John Hardy, Henrik Zetterberg
The acute and long-term consequences of traumatic brain injury (TBI) have received increased attention in recent years. In this Review, we discuss the neuropathology and neural mechanisms associated with TBI, drawing on findings from sports-induced TBI in athletes, in whom acute TBI damages axons and elicits both regenerative and degenerative tissue responses in the brain and in whom repeated concussions may initiate a long-term neurodegenerative process called dementia pugilistica or chronic traumatic encephalopathy (CTE)...
December 6, 2012: Neuron
https://www.readbyqxmd.com/read/23206160/review-the-long-term-consequences-of-microglial-activation-following-acute-traumatic-brain-injury
#19
REVIEW
C Smith
The brain is vulnerable to a number of acute insults, with traumatic brain injury being among the commonest. Neuroinflammation is a common response to acute injury and microglial activation is a key component of the inflammatory response. In the acute and subacute phase it is likely that this response is protective and forms an important part of the normal tissue reaction. However, there is considerable literature demonstrating an association between acute traumatic brain injury to the brain and subsequent cognitive decline...
February 2013: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/23199428/an-overview-of-the-basic-science-of-concussion-and-subconcussion-where-we-are-and-where-we-are-going
#20
REVIEW
Matthew L Dashnaw, Anthony L Petraglia, Julian E Bailes
There has been a growing interest in the diagnosis and management of mild traumatic brain injury (TBI), or concussion. Repetitive concussion and subconcussion have been linked to a spectrum of neurological sequelae, including postconcussion syndrome, chronic traumatic encephalopathy, mild cognitive impairment, and dementia pugilistica. A more common risk than chronic traumatic encephalopathy is the season-ending or career-ending effects of concussion or its mismanagement. To effectively prevent and treat the sequelae of concussion, it will be important to understand the basic processes involved...
December 2012: Neurosurgical Focus
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