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Malcolm Proudfoot, Freek van Ede, Andrew Quinn, Giles L Colclough, Joanne Wuu, Kevin Talbot, Michael Benatar, Mark W Woolrich, Anna C Nobre, Martin R Turner
OBJECTIVES: The neural activity of the primary motor cortex is variably synchronised with contralateral peripheral electromyographic signals, which is thought to facilitate long-range communication through the motor system. Such corticomuscular coherence (CMC) is typically observed in the beta-band (15-30 Hz) range during steady force production. We aimed to measure pathological alteration to CMC resulting from ALS. METHODS: CMC was appraised during a forearm grip task in 17 ALS patients contrasted against age-matched healthy controls...
April 6, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Yui Yamaoka, Nanako Tamiya, Akimitsu Watanabe, Yayoi Miyazono, Ryuta Tanaka, Akemi Matsuzawa, Ryo Sumazaki
BACKGROUND: Few researches have been reported hospital-based care utilization of children with medical complexity (CMC) in Japan. This study examined frequency and differences of hospital-based care utilization among moderate and severe CMC in Japan. METHODS: This study utilized medical records of three pediatric tertiary hospitals in one prefecture, 2014. We examined the numbers of outpatient visits and admissions to the hospital for CMC during 5 years after medical care at home was introduced...
April 20, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Beatrice L Grasu, Andrew J Trontis, Brent G Parks, Raymond A Wittstadt
BACKGROUND: Suture-button fixation is an alternative to no fixation, first metacarpal distraction techniques, or Kirschner wire fixation after trapeziectomy in treatment of first carpometacarpal (CMC) arthritis. A 4-strand suture-button construct requires a 2.7-mm tunnel, whereas a 2-strand construct requires a 1.1-mm tunnel, potentially decreasing the risk of metacarpal fracture. We compared stability and failure criteria of 4-strand versus 2-strand construct in a biomechanical model of first CMC joint arthroplasty...
April 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
Michaeline Jensen, Andrea M Hussong, Jeesook Baik
Alcohol-related content on public social networking sites (SNS) has been linked to collegiate alcohol use, but we know little about whether and how private forms of computer-mediated communication (CMC), like text messaging, are related to collegiate drinking, nor how alcohol-related CMC content and drinking are associated in non-Western cultures. We examined the ways in which private text messaging and SNS are used to facilitate alcohol involvement among U.S. (n = 575) and Korean (n = 462) college students (total N = 1037), two technologically wired cultures with prevalent collegiate alcohol misuse...
April 18, 2018: Cyberpsychology, Behavior and Social Networking
Kaibo Huang, Guining Lu, Zhiqiang Zheng, Rui Wang, Ting Tang, Xueqin Tao, Ruibing Cai, Zhi Dang, Pingxiao Wu, Hua Yin
Currently, photodegradation has been proven to be an important way of eliminating polybrominated diphenyl ethers (PBDEs) from the environment. However, the mechanism of PBDE photodegradation in surfactants by UV light is still unclear. In this study, 2,4,4'-tribrominated diphenyl ether (BDE-28) was selected as the target pollutant to investigate the photodegradation of PBDEs in Triton X-100 (TX-100), sodium dodecylbenzenesulfonate (SDBS) and cetyltrimethylammonium bromide (CTAB) solutions. All photolysis experiments were performed above the critical micelle concentration (CMC)...
April 17, 2018: Environmental Science. Processes & Impacts
Laura Engelke, Gerhard Winter, Julia Engert
The intradermal delivery of biologics has long been recognized as attractive approach for cutaneous immunotherapy, particularly vaccination. Although intradermal (i.d.) or subcutaneous (s.c.) injection provide reproducible dosing and good cost- and delivery efficiency, the major objective to avoid sharps and the need for enhanced storage stability have renewed the interest in alternative needle-free delivery strategies. This study presents a new concept for the delivery of macromolecules and nanoparticles to viable skin layers with a high density of professional antigen-presenting cells (APCs)...
April 13, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Jun Hai, Tianrong Li, Junxia Su, Wensheng Liu, Yanmin Ju, Baodui Wang, Yanglong Hou
Fingerprint fluorescence imaging has become one of the most prominent technologies in the field of forensic medicine, but it seldom considers the security protection of detection information, which is of great importance in modern society. Here we demonstrate that ClO-/SCN- reversibly responsive luminescent Tb(III) carboxymethyl-cellulose (CMC) complex-binding aptamer hydrogels can be used to realize selective detection, protection, and storage of fingerprint information. The imaging information of the fingerprint can be quenched and recovered by using ClO-/SCN- regulation, respectively, resulting in reversible on/off conversion of the luminescent signals in the process of encryption and decryption of multiple information...
April 16, 2018: Angewandte Chemie
Xin Xin Zhou, Long Jin, Rui Qun Qi, Teng Ma
In the present study, a novel pH-responsive amphiphilic copolymer, 1,2-distearoyl- sn -glycero-3-phosphoethanolamine- N -[methoxy(polyethylene glycol)] conjugated poly(β-amino esters) (DSPE- b -PEG- b -PAE- b -PEG- b -DSPE), was designed and successfully synthesized via Michael-type step polymerization. The chemical structure of the pentablock copolymer was confirmed with proton nuclear magnetic resonance (1 H-NMR) and Fourier transform infrared (FT-IR) spectroscopy. The copolymer was able to self-assemble into core/shell polymeric micelles in aqueous solution at low concentrations, and its critical micelle concentration (CMC) value was 4...
March 2018: Royal Society Open Science
Xiao-Kui Huo, Jing Liu, Zhen-Long Yu, Yi-Fei Wang, Chao Wang, Xiang-Ge Tian, Jing Ning, Lei Feng, Cheng-Peng Sun, Bao-Jing Zhang, Xiao-Chi Ma
BACKGROUND: Cholestasis is a clinical syndrome of liver damage that is caused by accumulation of bile acids in the liver and systemic circulation. Farnesoid X receptor (FXR) can regulate synthesis, metabolism, and excretion of bile acids. The rhizomes of Alisma orientale is a well-known traditional Chinese medicine to treat edema, obesity, gonorrhea, leukorrhea, diarrhea, hyperlipidemia, and diabetes in China. HYPOTHESIS/PURPOSE: We hypothesized Alisma orientale extract (AOE) to exert hepatoprotective effect against α-naphthylisothiocyanate (ANIT) induced cholestasis in rat...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Michael A Vogelbaum, Cathy Brewer, Gene H Barnett, Alireza M Mohammadi, David M Peereboom, Manmeet S Ahluwalia, Shenqiang Gao
OBJECTIVE Progress in management of high-grade gliomas (HGGs) has been hampered by poor access of potential therapeutics to the CNS. The Cleveland Multiport Catheter (CMC), which deploys 4 independent delivery microcatheters, was developed to be a reliable, high-volume delivery device for delivery of therapeutic agents to the brain and other solid organs. The authors undertook this first-in-human clinical trial effort to evaluate the delivery characteristics of the CMC in patients with HGGs. METHODS A series of pilot studies were launched after approval of a sponsor-investigator IND (investigational new drug) application to evaluate the delivery of topotecan and gadolinium-DTPA (Gd-DTPA) via the CMC in patients with recurrent HGG...
April 13, 2018: Journal of Neurosurgery
M Kaci, A Belhaffef, S Meziane, G Dostert, P Menu, É Velot, S Desobry, E Arab-Tehrany
Emulsion-based delivery systems have been developed to increase the topical bioavailability of lipophilic active compounds within skin membrane. The aim was to develop nanoemulsion from natural sources (rapeseed oil) with the same sources of pure phospholipids (lecithin) rich on mono and polyunsaturated fatty acids for encapsulation of hydrophobic antioxidant (Coenzyme Q10 ) giving nanoemulsion with double functionality. Nanoemulsions were used for cream preparation using xanthan gum and carboxylmethylcellulose as texturizing agents...
April 5, 2018: Colloids and Surfaces. B, Biointerfaces
Apichai Sawisit, Surawee Jampatesh, Sirima Suvarnakuta Jantama, Kaemwich Jantama
Rice straw was pretreated with sodium hydroxide (NaOH) before subsequent use for succinate production by Escherichia coli KJ122 under simultaneous saccharification and fermentation (SSF). The NaOH pretreated rice straw was significantly enhanced lignin removal up to 95%. With the optimized enzyme loading of 4% cellulase complex + 0.5% xylanase (endo-glucanase 67 CMC-U/g, β-glucosidase 26 pNG-U/g and xylanase 18 CMC-U/g dry biomass), total sugar conversion reached 91.7 ± 0.8% (w/w). The physicochemical analysis of NaOH pretreated rice straw indicated dramatical changes in its structure, thereby favoring enzymatic saccharification...
March 30, 2018: Bioresource Technology
Rosa D'Apolito, Antonio Perazzo, Valentina Preziosi, Mariapia D'Antuono, Giovanna Tomaiuolo, Reinhard Miller, Stefano Guido
Interfacial tension is a key parameter affecting industrially-relevant properties of emulsions, such as morphology and stability. Although several methods are available from the literature to measure interfacial tension, they are based on generation of droplets starting from separate emulsion components and cannot directly probe the interfacial tension of an emulsion the way it is. Here, a novel microfluidic tensiometry device to measure interfacial tension of a water in oil emulsion in situ as a function of surfactant concentration is presented...
April 11, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Jun Ye, Mingming Zhang, Jian Xiong
A novel, rapid, high selective and sensitive probe, carboxymethyl cellulose (CMC)/Tb(III) with green fluorescence, for detecting Mn2+ in aqueous solution during pH = 4-10 was proposed in this work. The probe's synthesis had benefits of mild reaction condition, organic solvent-free and facile operation. A linear relationship between the fluorescence intensity of CMC/Tb(III) probe at 544 nm with 0.046 μM detection limitation and the concentration of Mn2+ in the range of 0.1-100 μM was obtained. The probe was also used to detected Mn2+ in tap water and the recoveries were between 97...
June 15, 2018: Carbohydrate Polymers
Martina Cecotti, Bibiana M Coppotelli, Verónica C Mora, Marisa Viera, Irma S Morelli
Shifts in the bacterial-community dynamics, bioavailability, and biodegradation of polycyclic aromatic hydrocarbons (PAHs) of chronically contaminated soil were analyzed in Triton X-100-treated microcosms at the critical micelle concentration (T-CMC) and at two sub-CMC doses. Only the sub-CMC-dose microcosms reached sorbed-PAH concentrations significantly lower than the control: 166±32 and 135±4mgkg-1 dry soil versus 266±51mgkg-1 ; consequently an increase in high- and low-molecular-weight PAHs biodegradation was observed...
April 5, 2018: Science of the Total Environment
Neshatul Haque, N Prakash Prabhu
The interfacial activity of pancreatic lipases (PL) depends on the presence of colipase and bile salt. The activity of PL is inhibited by micellar concentrations of bile salt which can be restored by the addition of colipase. Though the formation of 1:1:1 tertiary complex by lipase-colipase-bile salt micelle is well accepted, the residue-level interactions between lipase-colipase and bile salt are yet to be clearly understood. Molecular dynamic simulations of lipase-colipase complex, lipase and colipase were performed in the presence of a model bile salt, sodium taurocholate (NaTC), at its near-CMC and supra-micellar concentrations...
April 4, 2018: Biochemical and Biophysical Research Communications
Sampson Anankanbil, Bianca Pérez, Chiranjib Banerjee, Zheng Guo
HYPOTHESIS: In multi-phase systems, many complex reactions take place at the interface where a molecule equipped with manifold functionalities is demanded. By taking advantage of the surface-active property of phosphatidylcholine (PC) scaffold and antioxidant properties of phenolic acids, new multifunctional molecules are generated, which are expected to confer physical and oxidative stability to sensitive bioactive ingredients in delivery systems. EXPERIMENTS: This work reports a successful synthesis of two new arrays of phenophospholipids sn-1-acyl(C12-C18)-sn-2-caffeoyl and sn-1-caffeoyl-sn-2-acyl phosphatidylcholines via mild scalable regiospecific pathways; as structurally verified by MS,1 H/13 C NMR analyses, and characterized by critical micelle concentrations (CMC), FTIR, and DSC analysis...
March 28, 2018: Journal of Colloid and Interface Science
Jian Tang, Shufang Ye, Xueliang Ji, Feng Liu, Zhaoshen Li
BACKGROUND AND AIM: Esophageal stricture is a serious adverse event secondary to extensive endoscopic submucosal dissection (ESD). This study aimed to investigate the efficacy of carboxymethyl cellulose (CMC) sheets for the prevention of esophageal stricture after full circumferential ESD in animal model. METHODS: Fourteen porcine models were randomized into a control group (n=7) and a CMC group (n=7). Five centimeters long circumferential esophageal ESD was performed at a distance of 40 to 45cm from the incisors in all models...
April 4, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Sarwat Jahan, Abira Abid, Sidra Khalid, Tayyaba Afsar, Qurat-Ul-Ain, Ghazala Shaheen, Ali Almajwal, Suhail Razak
BACKGROUND: PCOS is a leading endocrinopathy of young women instigating androgens elevation, insulin resistance, obesity, cardiometabolic and menstrual complications. The study investigated the effects of quercetin in a letrozole induced rat model of polycystic ovarian syndrome, which displayed both clinical and metabolic features as in PCOS women. METHODS: Female Sprague Dawley (SD) rats were divided into four groups; control group received aqueous solution of carboxymethyl (CMC 0...
April 3, 2018: Journal of Ovarian Research
Iana Pyrogova, Limsoon Wong
Proteins physically interact with each other and form protein complexes to perform their biological functions. The prediction of protein complexes from protein-protein interaction (PPI) network is usually difficult when the complexes are overlapping with each other in a dense region of the network. To address the problem of predicting overlapping complexes, a previously proposed network-decomposition approach is promising. It decomposes a PPI network by e.g. removing proteins with high degree (hubs) which may participate in different complexes...
March 23, 2018: Computational Biology and Chemistry
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