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https://www.readbyqxmd.com/read/28646437/cytotoxic-and-genotoxic-effects-of-silver-nanoparticle-carboxymethyl-cellulose-on-allium-cepa
#1
Aline A Becaro, Maria Célia Siqueira, Fernanda C Puti, Marcia Regina de Moura, Daniel S Correa, José Manoel Marconcini, Luiz H C Mattoso, Marcos David Ferreira
Several mutagenic agents may be present in substances released in the environment, which may cause serious environmental impacts. Among these substances, there is a special concern regarding the widespread use of silver nanoparticles (AgNP) in several products due to their widely known bactericidal properties, including in the medical field and the food industry (e.g., active packaging). The assessment of the effects of AgNP released in the environment, having different concentrations, sizes, and being associated or not to other types of materials, including polymers, is therefore essential...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28642862/fabrication-of-cmc-g-pam-superporous-polymer-monoliths-via-eco-friendly-pickering-mipes-for-superior-adsorption-of-methyl-violet-and-methylene-blue
#2
Feng Wang, Yongfeng Zhu, Wenbo Wang, Li Zong, Taotao Lu, Aiqin Wang
A series of superporous carboxymethylcellulose-graft-poly(acrylamide)/palygorskite (CMC-g-PAM/Pal) polymer monoliths presenting interconnected pore structure and excellent adsorption properties were prepared by one-step free-radical grafting polymerization reaction of CMC and acrylamide (AM) in the oil-in-water (O/W) Pickering-medium internal phase emulsions (Pickering-MIPEs) composed of non-toxic edible oil as a dispersion phase and natural Pal nanorods as stabilizers. The effects of Pal dosage, AM dosage, and co-surfactant Tween-20 (T-20) on the pore structures of the monoliths were studied...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28638287/use-of-sodium-hyaluronate-carboxymethylcellulose-bioresorbable-membrane-in-loop-ileostomy-construction-facilitates-stoma-closure
#3
Danielle M Bertoni, Kerry L Hammond, David E Beck, Terry C Hicks, Charles B Whitlow, H David Vargas, David A Margolin
BACKGROUND: Loop ileostomy is a common adjunct to surgical procedures for low rectal cancers and inflammatory bowel disease. Ileostomy closure through a limited incision can be technically challenging. We hypothesized that placing a sodium hyaluronate/carboxymethylcellulose (SH/CMC) bioresorbable membrane at loop ileostomy creation would decrease stoma closure time without increasing morbidity. METHODS: In a retrospective review at a single institution with 6 board-certified colorectal surgeons, patients with loop ileostomy creation and closure between September 1999 and December 2011 were grouped based on SH/CMC placement at ileostomy creation...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28637416/mixed-micelles-as-nano-polymer-therapeutics-of-docetaxel-increased-in-vitro-cytotoxicity-and-decreased-in-vivo-toxicity
#4
Arehalli S Manjappa, Popat S Kumbhar, Prajakta S Khopade, Ajit B Patil, John I Disouza
Docetaxel (DTX) has been used to treat several types of cancers, but it has provided pharmaceutical challenges due to its poor water solubility and toxicities associated with the co-solvents (tween-80 and ethanol). Nanopolymer therapeutics can be engineered to deliver anticancer agent specifically to cancer cells, thereby leaving normal healthy cells unaffected by toxic drugs such as DTX. The objective of the present study was to synthesize the polyacrylic acid (PAA)-DTX conjugate (PAADC) and preparation of nanopolymer therapeutics such as PAADC/DSPE-mPEG2000 mixed micelles (PAADC-DP MMs)...
June 21, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28637187/identification-of-pulmonary-vein-reconnection-gaps-with-high-density-mapping-in-redo-atrial-fibrillation-ablation-procedures
#5
Ignacio García-Bolao, Gabriel Ballesteros, Pablo Ramos, Diego Menéndez, Ane Erkiaga, Renzo Neglia, Marta Jiménez Martín, Enrique Vives-Rodríguez
Aims: Maps obtained by means of electroanatomic high-density mapping (HDM) systems have shown their use in the identification of conduction gaps in experimental atrial linear lesion models. The objective of this study was to assess the use of HDM in the recognition of reconnection gaps in pulmonary veins (PV) in redo atrial fibrillation (AF) ablation procedures. Methods and results: One hundred and eight patients were included in a non-randomized study that assessed the recognition of reconnection gaps in PV by means of HDM compared to a control group that received conventional non-fluoroscopic guidance with a circular multipolar catheter (CMC)...
June 20, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28630840/suspension-arthroplasty-combined-with-ligament-reconstruction-of-the-thumb-carpometacarpal-joint-to-salvage-two-failed-arthroplasties-a-case-report
#6
Ryosuke Kakinoki, Kazuhiko Hashimoto, Hiroki Tanaka, Masao Akagi
INTRODUCTION: Thumb basal joint arthroplasty with removal of the entire trapezium is often followed by proximal subsidence and impingement of the thumb metacarpal to the scaphoid, which is a common cause of post-operative thumb pain. Treatment of this impingement is a challenge among surgeons. We performed suspension arthroplasty combined with intercarpal ligament reconstruction using a strip of the extensor carpi radialis longus (ECRL) tendon on a patient suffering from pain caused by this type of the impingement and obtained a successful outcome...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28629858/preparation-characterization-and-antioxidant-activity-of-silk-peptides-grafted-carboxymethyl-chitosan
#7
Meng Liu, Lian Min, Chen Zhu, Ziqie Rao, Liangling Liu, Wenyan Xu, Pengfeng Luo, Lihong Fan
Free radicals are closely related to the occurrence and development of aging, cancer and inflammation, the ability to scavenge free radicals is an important indicator of the antioxidant activity. In this study, we prepared a water soluble, free radical scavenging and biocompatible copolymer for regenerative therapy. Carboxymethyl chitosan (CMC) was modified with silk peptide (SP) by microbial transglutaminase (MTGase), FT-IR and NMR spectroscopy were used to confirm the successful grafting of SP to CMC. The degree of substitution was determined by ultraviolet spectrophotometry...
June 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28629036/intestine-targeted-delivery-potency-of-the-o-carboxymethyl-chitosan-gum-arabic-coacervate-effects-of-coacervation-acidity-and-possible-mechanism
#8
Guo-Qing Huang, Li-Na Liu, Xiao-Na Han, Jun-Xia Xiao
The potential of the glutaraldehyde-crosslinked O-carboxymethyl chitosan (O-CMC)-gum Arabic (GA) coacervate as an intestine-targeted delivery system for hydrophobic compounds was concerned. OCMC-GA coacervates and emulsified bovine serum albumin (BSA)-loaded microcapsules were prepared in pH3.0, 4.5, and 6.0 and their swelling behaviors as well as BSA release profiles in simulated gastrointestinal fluids were measured. All the coacervates showed higher swelling ratios in the simulated gastric solution than in the simulated intestine and colon solutions and the values increased as the coacervation pH increased from 3...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628296/enhanced-antibacterial-properties-of-self-assembling-peptide-amphiphiles-functionalized-with-heparin-binding-cardin-motifs
#9
Run Chang, Keerthana Subramanian, Mian Wang, Thomas J Webster
The emergence of antibiotic resistance in bacteria has caused many healthcare problems and social burdens. Herein, we designed and studied self-assembled peptide amphiphiles (PAs) functionalized with a heparin-binding Cardin-motif peptide (sequence (AKKARK)2) to combat bacteria drug resistance. These amphiphilic Cardin antimicrobial peptides (ACA-PAs) self-assembled into nanorods (7-10 nm in diameter) with the cationic Cardin-motif peptide exposed on the surface. The ACA nanorods formed above the critical micelle concentration (CMC) of 45 µM into a β-sheet secondary structure...
June 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28627875/preparation-of-gemini-surfactant-conjugated-polymer-aggregates-for-enhanced-fluorescence-and-bioimaging-application
#10
Hua Wang, Lingyun Zhou, Chengcheng Zhou, Weiwei Zhao, Jianwu Wang, Libing Liu, Shu Wang, Yilin Wang
Conjugated polymers have great potential applications in bioimaging. However, the aggregation of conjugated polymers driven by electrostatic and hydrophobic interactions in aqueous media results in the reduction of photoluminescence quantum efficiency. In present work we synthesized a carboxylate gemini surfactant (SDHC) to adjust the aggregation behaviors and fluorescence properties of conjugated polymers (anionic MPS-PPV and cationic PMNT). This gemini surfactant shows very low critical micellar concentration (CMC) in aqueous solution and forms vesicles above CMC...
June 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28627454/synthesis-physiochemical-characterization-and-in-vitro-antitumor-activity-of-the-amide-and-ph-cleavable-hydrazone-conjugates-of-%C3%AE-tocotrienol-isomer-of-vitamin-e-with-methoxy-poly-ethylene-glycol
#11
Ahmed Abu-Fayyad, Sami Nazzal
The anticancer activity of water soluble methoxy polyethylene glycol (mPEG) derivatives of tocotrienol (T3) isomers of vitamin E was previously found to be reduced when compared to the parent free isomers. This could be due to the ester bond formation between the mPEG and the 6-OH group on the chroman moiety of the T3 isomer. To further investigate, the objectives of the current study were to (1) synthesize and characterize stable amide and cleavable hydrazone conjugates between mPEG and carbon-5 on the chroman moiety of T3, and (2) examine the cytotoxicity of the newly synthesized mPEG conjugates against breast (MCF-7 and MDA-MB-231) and pancreatic (BxPC-3 and PANC-1) cancer cells...
June 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28624736/fluorescence-of-tautomeric-forms-of-curcumin-in-different-ph-and-biosurfactant-rhamnolipids-systems-application-towards-on-off-ratiometric-fluorescence-temperature-sensing
#12
Zeinab Moussa, Mazhar Chebl, Digambara Patra
Medicinal properties of curcumin are widely getting realized. For its applicability as a hydrophobic drug molecule and food spice interaction of curcumin with rhamnolipids, a biosurfactant, bears importance. Here we have explored interaction of curcumin with rhamnolipids biosurfactant and its aggregation behavior. The impact of pH on critical micelle concentration (cmc) of rhamnolipids has been studied using fluorescence of curcumin and found that cmc of rhamnolipids increases with increase in pH of the medium...
June 11, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28624378/glucose-triggered-enhanced-solubilisation-release-and-cytotoxicity-of-poorly-water-soluble-anti-cancer-drugs-fromt1307-micelles
#13
Pooja Patidar, Sadafara A Pillai, Urjita Sheth, Pratap Bahadur, Anita Bahadur
Tetronic(®) 1307 (here after written as T1307) is a hydrophilic ethylene oxide-propylene oxide (EO-PO) star block copolymer with long EO chains (Total MW- 18000 and 70% EO). Although biocompatible, its use as a nanocarrier is restricted owing to its high critical micelle concentration (CMC) and temperature (CMT). We examined if the addition of glucose, a common pharmaceutical ingredient promotes micellization. Scattering and thermal studies show formation of stable unimodal micelles and cloud point (CP) decreased linearly...
June 15, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28623337/impact-of-module-x2-and-carbohydrate-binding-module-3-on-the-catalytic-activity-of-associated-glycoside-hydrolases-towards-plant-biomass
#14
Nandita Pasari, Nidhi Adlakha, Mayank Gupta, Zeenat Bashir, Girish H Rajacharya, Garima Verma, Manoj Munde, Rakesh Bhatnagar, Syed Shams Yazdani
Cellulolytic enzymes capable of hydrolyzing plant biomass are secreted by microbial cells specifically in response to the carbon substrate present in the environment. These enzymes consist of a catalytic domain, generally appended to one or more non-catalytic Carbohydrate Binding Module (CBM), which enhances their activity towards recalcitrant biomass. In the present study, the genome of a cellulolytic microbe Paenibacillus polymyxa A18 was annotated for the presence of CBMs and analyzed their expression in response to the plant biomass and model polysaccharides Avicel, CMC and xylan using quantitative PCR...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28622416/rosacea-and-demodicidosis-associated-with-gain-of-function-mutation-in-stat1
#15
Julie Second, Anne-Sophie Korganow, Sarah Jannier, Anne Puel, Dan Lipsker
We report a family in which 3 of 5 children as well as the mother, had a gain-of-function (GOF) mutation in the signal transducer and activator of transcription (STAT1) associated with early-onset rosacea and demodicidosis. The proband case (Fig. 1) was a 13-year-old boy of non-consanguineous parents, known for a hypothyroidism, failure to thrive and chronic mucocutaneous candidiasis (CMC) since he was 5-6 years old. On examination, he had medio-facial erythema with telangiectasia, as well as sometimes pruritic papulopustular lesions of the face and neck...
June 16, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28617325/development-of-biopolymer-composite-films-using-a-microfluidization-technique-for-carboxymethylcellulose-and-apple-skin-particles
#16
Inyoung Choi, Yoonjee Chang, So-Hyang Shin, Eunmi Joo, Hyun Ju Song, Haeyoung Eom, Jaejoon Han
Biopolymer films based on apple skin powder (ASP) and carboxymethylcellulose (CMC) were developed with the addition of apple skin extract (ASE) and tartaric acid (TA). ASP/CMC composite films were prepared by mixing CMC with ASP solution using a microfluidization technique to reduce particle size. Then, various concentrations of ASE and TA were incorporated into the film solution as an antioxidant and an antimicrobial agent, respectively. Fourier transform infrared (FTIR), optical, mechanical, water barrier, and solubility properties of the developed films were then evaluated to determine the effects of ASE and TA on physicochemical properties...
June 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28616787/subtle-radiographic-signs-of-hamate-body-fracture-a-diagnosis-not-to-miss-in-the-emergency-department
#17
Nathan D Cecava, Mary F Finn, Liem T Mansfield
Hamate fractures are estimated to represent 1.7% of all carpal fractures and can occur at the hamulus (hook) or hamate body depending on mechanism of injury. Fractures of the hamate body can be exceedingly difficult to identify on standard wrist and hand radiographs in the emergency department. If the diagnosis is missed in the emergency department, orthopedic referral is often delayed. This can result in lasting functional disability for the patient, as these fractures have a propensity to destabilize the fourth and fifth carpometacarpal (CMC) joints...
June 14, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28611745/the-hybrid-strategy-of-thermoactinospora-rubra-yim-77501-t-for-utilizing-cellulose-as-a-carbon-source-at-different-temperatures
#18
Yi-Rui Yin, Zhao-Hui Meng, Qing-Wen Hu, Zhao Jiang, Wen-Dong Xian, Lin-Hua Li, Wei Hu, Feng Zhang, En-Min Zhou, Xiao-Yang Zhi, Wen-Jun Li
Thermoactinospora rubra YIM 77501(T) is an aerobic, Gram-positive, spore-forming and cellulose degrading thermophilic actinomycete isolated from a sandy soil sample of a volcano. Its growth temperature range is 28-60°C. The genomic sequence of this strain revealed that there are 27 cellulase genes belonging to six glycoside hydrolase families. To understand the strategy that this strain uses to utilize carbon sources such as cellulose at different temperatures, comparative transcriptomics analysis of T. rubra YIM 77501(T) was performed by growing it with cellulose (CMC) and without cellulose (replaced with glucose) at 30, 40, and 50°C, respectively...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28608760/plga-peg-ra-based-polymeric-micelles-for-tumor-targeted-delivery-of-irinotecan
#19
Jaber Emami, Parnian Maghzi, Farshid Hasanzadeh, Hojjat Sadeghi, Mina Mirian, Mahboubeh Rostami
To develop an effective therapeutic treatment, the potential of poly (lactic-co-glycolic acid)-polyethylene glycol-retinoic acid (PLGA-PEG-RA) polymeric micelles for targeted delivery of irinotecan to hepatocellular carcinoma (HepG2) and colorectal cancer cell lines (HT-29) was evaluated. PLGA-PEG-RA was synthesized by amide reaction of PLGA with NH2-PEG-NH2 and then PLGA-PEG-NH2 with RA and confirmed by FTIR and (1)H NMR spectroscopy. Irinotecan-loaded nanomicelles were prepared using thin-film hydration method and the impact of various formulation variables on their particle size (PS), polydispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE), and mean release time (MRT) were assessed using a Taguchi design...
June 13, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28605906/micellization-and-antimicrobial-properties-of-surface-active-ionic-liquids-containing-cleavable-carbonate-linkages
#20
M Teresa Garcia, Isabel Ribosa, Lourdes Perez, Angeles Manresa, Francesc Comelles
Imidazolium-based ionic liquids (ILs) containing cleavable carbonate linkages, 1-alkyloxycarbonyloxyethyl-3-methylimidazolium chlorides with alkyl chains of 10, 12, and 14 carbon atoms, were synthesized, and their self-assembly behavior and antimicrobial activity were investigated. Differential scanning calorimetry and polarized optical microscopy studies reveal that carbonate-functionalized ILs form stable thermotropic smectic liquid-crystalline phases over a wide range of temperature. The surface activity and aggregation behavior of these new ILs were investigated by tensiometry, conductometry, potentiometry, and spectrofluorimetry...
June 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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