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https://www.readbyqxmd.com/read/28543788/automated-verification-of-pulmonary-vein-isolation-in-radiofrequency-and-cryoballoon-guided-ablation
#1
Jan De Pooter, Thomas Phlips, Milad El Haddad, Frederic van Heuverswyn, Liesbeth Timmers, René Tavernier, Sebastien Knecht, Yves Vandekerckhove, Mattias Duytschaever
BACKGROUND: Verification of pulmonary vein isolation (PVI) can be challenging due to the coexistence of pulmonary vein potentials (PVP) and far field potentials. This study aimed to prospectively validate a novel algorithm for automated verification of PVI in radiofrequency-guided (RF) and cryoballoon-guided (CB) ablation strategies. METHODS: A dataset of 620 (RF: 516 EGMs and CB: 104 EGMs) bipolar electrograms (EGM), recorded by circular mapping catheter (CMC) placed at the left atrium-pulmonary vein (PV) junction, were prospectively analyzed by a two-step algorithm...
May 25, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28539204/nurses-perceptions-of-caring-for-parents-of-children-with-chronic-medical-complexity-in-the-pediatric-intensive-care-unit
#2
Gabrielle Denis-Larocque, Karl Williams, Isabelle St-Sauveur, Margaret Ruddy, Janet Rennick
OBJECTIVES: The aim of this study was to explore nurses' perceptions of caring for parents of children with medical complexity [CMC] in the pediatric intensive care unit [PICU]. RESEARCH METHODOLOGY: An interpretive descriptive design was used to explore nurses' perceptions of caring for parents of CMC in the PICU. Semi-structured interviews were conducted with ten nurses. Interview data were collected and analyzed using qualitative inductive content analysis. FINDINGS: Nurses revealed that their experiences of caring for parents of CMC evolved over time as they learned to tailor a caregiving partnership based on trust...
May 20, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28535067/emulsion-polymerization-with-a-biosurfactant
#3
Aya Kurozuka, Shohei Onishi, Takuto Nagano, Katsumi Yamaguchi, Toyoko Suzuki, Hideto Minami
Emulsion polymerization of styrene was conducted using a biosurfactant (i.e., sodium surfactin, hereinafter called just "surfactin") having very low critical micelle concentration (CMC, 2.9 × 10-3 mmol/L) and biodegradability characteristics. The nucleation mechanism was investigated by comparing with a conventional surfactant (i.e., sodium dodecyl sulfate, SDS) system. Unlike the emulsion polymerization systems using conventional surfactants, nucleation mechanisms changed above CMC in the presence of a biosurfactant...
May 23, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28534851/respiratory-care-considerations-for-children-with-medical-complexity
#4
REVIEW
Jackie Chiang, Reshma Amin
Children with medical complexity (CMC) are a growing population of diagnostically heterogeneous children characterized by chronic conditions affecting multiple organ systems, the use of medical technology at home as well as intensive healthcare service utilization. Many of these children will experience either a respiratory-related complication and/or they will become established on respiratory technology at home during their care trajectory. Therefore, healthcare providers need to be familiar with the respiratory related complications commonly experienced by CMC as well as the indications, technical and safety considerations and potential complications that may arise when caring for CMC using respiratory technology at home...
May 19, 2017: Children
https://www.readbyqxmd.com/read/28534138/a-chemically-modified-curcumin-cmc-2-24-inhibits-nuclear-factor-%C3%AE%C2%BAb-activation-and-inflammatory-bone-loss-in-murine-models-of-lps-induced-experimental-periodontitis-and-diabetes-associated-natural-periodontitis
#5
Muna S Elburki, Carlos Rossa, Morgana R Guimarães-Stabili, Hsi-Ming Lee, Fabiana A Curylofo-Zotti, Francis Johnson, Lorne M Golub
The purpose of this study was to assess the effect of a novel chemically modified curcumin (CMC 2.24) on NF-κB and MAPK signaling and inflammatory cytokine production in two experimental models of periodontal disease in rats. Experimental model I: Periodontitis was induced by repeated injections of LPS into the gingiva (3×/week, 3 weeks); control rats received vehicle injections. CMC 2.24, or the vehicle, was administered by daily oral gavage for 4 weeks. Experimental model II: Diabetes was induced in adult male rats by streptozotocin injection; periodontal breakdown then results as a complication of uncontrolled hyperglycemia...
May 22, 2017: Inflammation
https://www.readbyqxmd.com/read/28532666/transcription-of-immune-related-genes-in-solea-senegalensis-vaccinated-against-photobacterium-damselae-subsp-piscicida-identification-of-surrogates-of-protection
#6
J A Núñez-Díaz, I García de la Banda, C Lobo, M A Moriñigo, M C Balebona
Solea senegalensis is a flatfish with a great potential for aquaculture, but infectious diseases restrict its production, being this fish species highly susceptible to Photobacterium damselae subsp. piscicida (Phdp) infections. A better understanding of the mechanisms related to fish immune response is crucial for the development of effective approaches in disease management. In the present work, transcriptional changes of immune related genes have been evaluated in farmed S. senegalensis specimens vaccinated against Phdp by intraperitoneal injection (IP) and immersion (IM)...
May 19, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28532064/encapsulation-of-lactobacillus-kefiri-in-alginate-microbeads-using-a-double-novel-aerosol-technique
#7
Christian Demitri, Leonardo Lamanna, Egidio De Benedetto, Fabrizio Damiano, Maria Stella Cappello, Luisa Siculella, Alessandro Sannino
Alginate micro beads containing Lactobacillus kefiri (the principal bacteria present in the kefir probiotic drink) were produced by a novel technique based on dual aerosols spaying of alginate based solution and CaCl2 as cross linking agent. Carboxymethylcellulose (CMC) has been also added to the alginate in order to change the physic-chemical properties (viscosity and permeability) of the microbeads. Calcium alginate and CMC are biopolymers that can be used for developing oral drug-delivery systems. These biopolymers have been reported to show a pH-dependent swelling behaviour...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532038/dynamic-covalent-linked-triblock-copolymer-micelles-for-glutathione-mediated-intracellular-drug-delivery
#8
Xueli Wang, Changyu He, Qinglai Yang, Lianjiang Tan, Bingya Liu, Zhenggang Zhu, Bing Gong, Yu-Mei Shen
Redox-responsive linkages dispersed in the backbones of the synthetic polymers, while young in the current spectrum of the biomedical application, are rapidly extending into their niche. In the present work, triblock copolymer PEG-PLA-PEG synthesized and characterized by (1)H -NMR and SEC can self-assemble into redox-responsive micelles in aqueous media with nanosized 33nm and 47nm. And the copolymers PEG2000-PLA3000-PEG2000 and PEG2000-PLA5000-PEG2000 present lower CMC with 0.034 and 0.022mg/mL, and higher DLC of 4...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531980/self-assembled-nanomicelles-of-damnacanthal-loaded-amphiphilic-modified-chitosan-preparation-characterization-and-cytotoxicity-study
#9
Pakin Sukamporn, Seung Joon Baek, Wandee Gritsanapan, Suwabun Chirachanchai, Thararat Nualsanit, Pleumchitt Rojanapanthu
Damnacanthal (Dam) is a phytochemical with many pharmacological properties including anticancer activity. However, its hydrophobicity, poor bioavailability and stability limit its application in many biological approaches. In this study, Dam nanomicelles as an emerging platform were developed to overcome limitations. The deoxycholic and poly(ethylene glycol) methyl ether grafted chitosan (DCA-CS-mPEG) was synthesized and characterized by FTIR and (1)H NMR and the degree of substitution (DS) was determined by elemental analysis (EA)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28528299/selective-targeting-and-therapy-of-metastatic-and-multidrug-resistant-tumors-using-a-long-circulating-podophyllotoxin-nanoparticle
#10
Aniruddha Roy, Yucheng Zhao, Yang Yang, Andras Szeitz, Tara Klassen, Shyh-Dar Li
Treatment options for metastatic and multidrug resistant (MDR) tumors are limited, and most of the chemotherapeutic drugs exhibit low efficacy against MDR cancers. An anti-tubulin agent podophyllotoxin (PPT) displays high potency against MDR tumor cells. However, due to its poor solubility and non-specificity, PPT cannot be used systemically. We have developed a self-assembling nanoparticle dosage form for PPT (named Celludo) by covalently conjugating PPT and polyethylene glycol (PEG) to acetylated carboxymethyl cellulose (CMC-Ac) via ester linkages...
May 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28526342/ph-controlled-drug-delivery-with-hybrid-aerogel-of-chitosan-carboxymethyl-cellulose-and-graphene-oxide-as-the-carrier
#11
Ren Wang, Dan Shou, Ouyang Lv, Yong Kong, Linhong Deng, Jian Shen
Hybrid aerogels of chitosan (CS), carboxymethyl cellulose (CMC) and graphene oxide (GO) are successfully prepared by using calcium ion (Ca(2+)) as the crosslinker. The resultant hybrid aerogels, CS/CMC/Ca(2+)/GO, are characterized by field emission scanning electron microscopy (FESEM) and Fourier transform infrared (FT-IR) spectroscopy. Due to the pH sensitivity of CS and CMC, pH-controlled drug delivery with CS/CMC/Ca(2+)/GO as the carrier is investigated using 5-fluorouracil (5-FU), an effective chemotherapeutic agent in the treatment of cancers, as the model drug...
May 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28525958/necessity-of-immobilizing-the-metacarpophalangeal-joint-in-carpometacarpal-osteoarthritis-short-term-effect
#12
Raquel Cantero-Téllez, Kristin Valdes, Deborah A Schwartz, Ivan Medina-Porqueres, Jean Christophe Arias, Jorge H Villafañe
BACKGROUND: Conservative treatment for carpometacarpal (CMC) joint osteoarthritis (OA) may include orthotic fabrication to decrease pain. Different types of orthoses have been used as conservative interventions to improve symptoms, but there are no guidelines specifying if inclusion of the thumb metacarpophalangeal (MCP) in an orthosis is required in the treatment of thumb CMC joint OA. The main objective of this study is to determine the effectiveness of 2 different thumb CMC joint orthotic designs on pain reduction and improved hand function: one design immobilizes both the MCP joint and the CMC joint and the other design immobilizes only the CMC joint...
May 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28523480/2-methoxylated-fa-display-unusual-antibacterial-activity-towards-clinical-isolates-of-methicillin-resistant-staphylococcus-aureus-cimrsa-and-escherichia-coli
#13
Néstor M Carballeira, Nashbly Montano, Christian Morales, Joseph Mooney, Xiomara Torres, Dakeishla Díaz, David J Sanabria-Rios
The naturally occurring (6Z)-(±)-2-methoxy-6-hexadecenoic acid (1) and (6Z)-(±)-2-methoxy-6-octadecenoic acid (2) were synthesized in 7-8 steps with 38 and 13% overall yields, respectively, by using an acetylide coupling approach, which made it possible to obtain a 100% cis-stereochemistry for the double bonds. In a similar fashion, the acetylenic analogs (±)-2-methoxy-6-hexadecynoic acid (3) and (±)-2-methoxy-6-octadecynoic acid (4) were also synthesized in 6-7 steps with 48 and 16% overall yields, respectively...
May 18, 2017: Lipids
https://www.readbyqxmd.com/read/28518073/extraction-and-characterization-of-surfactants-from-atmospheric-aerosols
#14
Barbara Nozière, Violaine Gérard, Christine Baduel, Corinne Ferronato
Surface-active compounds, or surfactants, present in atmospheric aerosols are expected to play important roles in the formation of liquid water clouds in the Earth's atmosphere, a central process in meteorology, hydrology, and for the climate system. But because specific extraction and characterization of these compounds have been lacking for decades, very little is known on their identity, properties, mode of action and origins, thus preventing the full understanding of cloud formation and its potential links with the Earth's ecosystems...
April 21, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28516499/spectrofluorometric-determination-of-clonazepam-in-dosage-forms-application-to-content-uniformity-testing-and-human-plasma
#15
Fathalla Belal, Fawzia Ibrahim, Zainab Sheribah, Heba Alaa
The present paper describes a developed and validated simple, highly sensitive and cost-effective spectrofluorometric method for determination of clonazepam (CNP). The proposed method depends on forming a highly fluorescent product through the reduction of CNP with Zn/HCl. The produced fluorophore exhibits a strong fluorescence at λem 350 nm after excitation at λex 250 nm. The use of carboxymethylcellulose (CMC) greatly enhanced the fluorescence intensity of the produced fluorophore to the extent of about 100%...
May 18, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28515785/recombinant-expression-of-thermostable-processive-mteg5-endoglucanase-and-its-synergism-with-mtlpmo-from-myceliophthora-thermophila-during-the-hydrolysis-of-lignocellulosic-substrates
#16
Anthi Karnaouri, Madhu Nair Muraleedharan, Maria Dimarogona, Evangelos Topakas, Ulrika Rova, Mats Sandgren, Paul Christakopoulos
BACKGROUND: Filamentous fungi are among the most powerful cellulolytic organisms in terrestrial ecosystems. To perform the degradation of lignocellulosic substrates, these microorganisms employ both hydrolytic and oxidative mechanisms that involve the secretion and synergism of a wide variety of enzymes. Interactions between these enzymes occur on the level of saccharification, i.e., the release of neutral and oxidized products, but sometimes also reflected in the substrate liquefaction...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28510440/fundamental-characterization-of-the-micellar-self-assembly-of-sophorolipid-esters
#17
Amanda Koh, Katherine Todd, Ezekiel Sherbourne, Richard A Gross
Surfactants are ubiquitous constituents of commercial and biological systems that function based on complex structure-dependent interactions. Sophorolipid (SL) n-alkyl esters (SL-esters) comprise a group of modified naturally derived glycolipids from Candida bombicola. Herein, micellar self-assembly behavior as a function of SL-ester chain length was studied. Surface tensions as low as 31.2 mN/m and critical micelle concentrations (CMCs) as low as 1.1µM were attained for diacetylated SL-decyl ester (dASL-DE) and SL-octyl ester, respectively...
May 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28507982/the-role-of-carrageenan-and-carboxymethylcellulose-in-the-development-of-intestinal-inflammation
#18
REVIEW
John Vincent Martino, Johan Van Limbergen, Leah E Cahill
Although the exact pathophysiology remains unknown, the development of inflammatory bowel disease (IBD) is influenced by the interplay between genetics, the immune system, and environmental factors such as diet. The commonly used food additives, carrageenan and carboxymethylcellulose (CMC), are used to develop intestinal inflammation in animal models. These food additives are excluded from current dietary approaches to induce disease remission in Crohn's disease such as exclusive enteral nutrition (EEN) using a polymeric formula...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28507538/candida-lipolytica-ucp0988-biosurfactant-potential-as-a-bioremediation-agent-and-in-formulating-a-commercial-related-product
#19
Danyelle K F Santos, Ana H M Resende, Darne G de Almeida, Rita de Cássia F Soares da Silva, Raquel D Rufino, Juliana M Luna, Ibrahim M Banat, Leonie A Sarubbo
The aim of the present study was to investigate the potential application of the biosurfactant from Candida lipolytica grown in low-cost substrates, which has previously been produced and characterized under optimized conditions as an adjunct material to enhance the remediation processes of hydrophobic pollutants and heavy metals generated by the oil industry and propose the formulation of a safe and stable remediation agent. In tests carried out with seawater, the crude biosurfactant demonstrated 80% oil spreading efficiency...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28506726/influence-of-xanthan-guar-cmc-and-gum-acacia-on-functional-properties-of-water-chestnut-trapa-bispinosa-starch
#20
Zubala Lutfi, Anjum Nawab, Feroz Alam, Abid Hasnain, Syed Zia Haider
This study was performed to determine the effect of xanthan, guar, CMC and gum acacia on functional and pasting properties of starch isolated from water chestnut (Trapa bispinosa). Morphological properties of water chestnut starch with CMC were studied by scanning electron microscopy (SEM). The addition of hydrocolloids significantly enhanced the solubility of water chestnut starch (WCS) while reduced swelling power and freeze-thaw stability. The hydrophilic tendency of WCS was increased by xanthan gum; however, with addition of gum acacia it decreased significantly...
May 12, 2017: International Journal of Biological Macromolecules
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