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https://www.readbyqxmd.com/read/29324406/a-novel-multi-class-eeg-based-sleep-stage-classification-system
#1
Pejman Memar, Farhad Faradji
Sleep stage classification is one of the most critical steps in effective diagnosis and the treatment of sleep-related disorders. Visual inspection undertaken by sleep experts is a time-consuming and burdensome task. A computer-assisted sleep stage classification system is thus essential for both sleep-related disorders diagnosis and sleep monitoring. In this paper, we propose a system to classify the wake and sleep stages with high rates of sensitivity and specificity. The EEG signals of 25 subjects with suspected sleep-disordered breathing, and the EEG signals of 20 healthy subjects from three data sets are used...
January 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29297590/involvement-of-the-delayed-rectifier-outward-potassium-channel-kv2-1-in-methamphetamine-induced-neuronal-apoptosis-via-the-p38-mitogen-activated-protein-kinase-signaling-pathway
#2
Jingying Zhu, Songsong Zang, Xufeng Chen, Lei Jiang, Aihua Gu, Jie Cheng, Li Zhang, Jun Wang, Hang Xiao
Methamphetamine (Meth) is an illicit psychostimulant with high abuse potential and severe neurotoxicity. Recent studies have shown that dysfunctions in learning and memory induced by Meth may partially reveal the mechanisms of neuronal channelopathies. Kv2.1, the primary delayed rectifying potassium channel in neurons, is responsible for mediating apoptotic current surge. However, whether Kv2.1 is involved in Meth-mediated neural injury remains unknown. In the present study, the treatment of primary cultured hippocampal neurons with Meth indicated that Meth induced a time- and dose-dependent augmentation of Kv2...
January 3, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29291374/af710b-an-m1-sigma-1-receptor-agonist-with-long-lasting-disease-modifying-properties-in-a-transgenic-rat-model-of-alzheimer-s-disease
#3
Hélène Hall, M Florencia Iulita, Palma Gubert, Lisi Flores Aguilar, Adriana Ducatenzeiler, Abraham Fisher, A Claudio Cuello
INTRODUCTION: AF710B (aka ANAVEX 3-71) is a novel selective allosteric M1 muscarinic and sigma-1 receptor agonist. In 3×Tg-AD mice, AF710B attenuates cognitive deficits and decreases Alzheimer-like hallmarks. We now report on the long-lasting disease-modifying properties of AF710B in McGill-R-Thy1-APP transgenic (Tg) rats. METHODS: Chronic treatment with AF710B (10 μg/kg) was initiated in postplaque 13-month-old Tg rats. Drug or vehicle was administered orally daily for 4...
December 29, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29289721/spinal-sigma-1-receptor-mediated-dephosphorylation-of-astrocytic-aromatase-plays-a-key-role-in-formalin-induced-inflammatory-nociception
#4
Hoon-Seong Choi, Mi-Ji Lee, Sheu-Ran Choi, Branden A Smeester, Alvin J Beitz, Jang-Hern Lee
Aromatase is a key enzyme responsible for the biosynthesis of estrogen from testosterone. Although recent evidence indicates that spinal cord aromatase participates in nociceptive processing, the mechanisms underlying its regulation and its involvement in nociception remain unclear. The present study focuses on the potential role of astrocyte aromatase in formalin-induced acute pain and begins to uncover one mechanism by which spinal aromatase activation is controlled. Following intraplantar formalin injection, nociceptive responses were quantified and immunohistochemistry/co-immunoprecipitation assays were used to investigate the changes in spinal Fos expression and the phospho-serine levels of spinal aromatase...
December 28, 2017: Neuroscience
https://www.readbyqxmd.com/read/29288053/the-histidine-phosphocarrier-protein-hpr-binds-to-the-highly-thermostable-regulator-of-sigma-d-protein-rsd-and-its-isolated-helical-fragments
#5
José L Neira, Felipe Hornos, Concetta Cozza, Ana Cámara-Artigas, Olga Abián, Adrián Velázquez-Campoy
The phosphotransferase system (PTS) controls the preferential use of sugars in bacteria and it is also involved in other processes, such as chemotaxis. It is formed by a protein cascade in which the first two proteins are general (namely, EI and HPr) and the others are sugar-specific permeases. The Rsd protein binds specifically to the RNA polymerase (RNAP) σ70 factor. We first characterized the conformational stability of Escherichia coli Rsd. And second, we delineated the binding regions of Streptomyces coelicolor, HPrsc, and E...
December 26, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29287249/multifunctional-thiosemicarbazones-and-deconstructed-analogues-as-a-strategy-to-study-the-involvement-of-metal-chelation-sigma-2-%C3%AF-2-receptor-and-p-gp-protein-in-the-cytotoxic-action-in%C3%A2-vitro-and-in%C3%A2-vivo-activity-in-pancreatic-tumors
#6
Maria Laura Pati, Mauro Niso, Dirk Spitzer, Francesco Berardi, Marialessandra Contino, Chiara Riganti, William G Hawkins, Carmen Abate
The aggressiveness of pancreatic cancer urgently requires more efficient treatment options. Because the sigma-2 (σ2) receptor was recently proposed as a promising target for pancreatic cancer therapy, we explored our previously developed multifunctional thiosemicarbazones, designed to synergistically impair cell energy levels, by targeting σ2 and P-gp proteins and chelating Iron. A deconstruction approach was herein applied by removing one function at a time from the potent multifunctional thiosemicarbazones 1 and 2, to investigate the contribution to cytotoxicity of each target involved...
December 8, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29281856/solar-irradiance-limits-the-long-term-survival-of-listeria-monocytogenes-in-seawater
#7
Kerrie NicAogáin, Denise Magill, Beth O'Donoghue, Alan Conneely, Claire Bennett, Conor P O'Byrne
Seafood has often been implicated in outbreaks of food-borne illness caused by Listeria monocytogenes but the source of contamination is usually not known. In this study we investigated the possibility that this pathogen could survive in seawater for an extended time period. Freshly collected seawater samples were inoculated with 1 x 108 CFU ml-1 of L. monocytogenes EGD-e and survival was monitored by plate counting for up to 25 d. When incubated in the dark, either at ambient temperatures (4-14°C) or at 16°C, greater than 104 CFU ml-1 survivors were present after 25 d...
December 27, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29273788/structure-of-a-wbl-protein-and-implications-for-no-sensing-by-m-tuberculosis
#8
Bassam K Kudhair, Andrea M Hounslow, Matthew D Rolfe, Jason C Crack, Debbie M Hunt, Roger S Buxton, Laura J Smith, Nick E Le Brun, Michael P Williamson, Jeffrey Green
Mycobacterium tuberculosis causes pulmonary tuberculosis (TB) and claims ~1.8 million human lives per annum. Host nitric oxide (NO) is important in controlling TB infection. M. tuberculosis WhiB1 is a NO-responsive Wbl protein (actinobacterial iron-sulfur proteins first identified in the 1970s). Until now, the structure of a Wbl protein has not been available. Here a NMR structural model of WhiB1 reveals that Wbl proteins are four-helix bundles with a core of three α-helices held together by a [4Fe-4S] cluster...
December 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29273047/donepezil-suppresses-intracellular-ca2-mobilization-through-the-pi3k-pathway-in-rodent-microglia
#9
Yoshinori Haraguchi, Yoshito Mizoguchi, Masahiro Ohgidani, Yoshiomi Imamura, Toru Murakawa-Hirachi, Hiromi Nabeta, Hiroshi Tateishi, Takahiro A Kato, Akira Monji
BACKGROUND: Microglia are resident innate immune cells which release many factors including proinflammatory cytokines or nitric oxide (NO) when they are activated in response to immunological stimuli. Pathophysiology of Alzheimer's disease (AD) is related to the inflammatory responses mediated by microglia. Intracellular Ca2+ signaling is important for microglial functions such as release of NO and cytokines. In addition, alteration of intracellular Ca2+ signaling underlies the pathophysiology of AD, while it remains unclear how donepezil, an acetylcholinesterase inhibitor, affects intracellular Ca2+ mobilization in microglial cells...
December 22, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29261160/smoothed-body-composition-percentiles-curves-for-mexican-children-aged-6-to-12-years
#10
Melchor Alpizar, Vanessa-Giselle Peschard, Fabiola Escalante-Araiza, Nelly F Altamirano-Bustamante, Chiharu Murata, Ramón Arenas-Pérez, Ernesto Rodriguez-Ayala
Overweight children and childhood obesity are a public health problem in Mexico. Obesity is traditionally assessed using body mass index (BMI), but an excess of adiposity does not necessarily reflect a high BMI. Thus, body composition indexes are a better alternative. Our objective was to generate body composition percentile curves in children from Mexico City. A total of 2026 boys and 1488 girls aged 6 to 12 years old were studied in Mexico City. Body weight, height, and BMI calculation were measured. Total body fat percentage (TBFP) was derived from the skinfold thicknesses, and fat mass (FMI) and free fat mass indexes (FFMI) were calculated...
December 20, 2017: Children
https://www.readbyqxmd.com/read/29259241/computational-detection-and-quantification-of-human-and-mouse-neutrophil-extracellular-traps-in-flow-cytometry-and-confocal-microscopy
#11
Brandon G Ginley, Tiffany Emmons, Brendon Lutnick, Constantin F Urban, Brahm H Segal, Pinaki Sarder
Neutrophil extracellular traps (NETs) are extracellular defense mechanisms used by neutrophils, where chromatin is expelled together with histones and granular/cytoplasmic proteins. They have become an immunology hotspot, implicated in infections, but also in a diverse array of diseases such as systemic lupus erythematosus, diabetes, and cancer. However, the precise assessment of in vivo relevance in different disease settings has been hampered by limited tools to quantify occurrence of extracellular traps in experimental models and human samples...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29240820/age-related-nomograms-for-antral-follicle-count-and-anti-mullerian-hormone-for-subfertile-chinese-women-in-singapore
#12
See Ling Loy, Yin Bun Cheung, Marielle Valerie Fortier, Chiou Li Ong, Heng Hao Tan, Sadhana Nadarajah, Jerry Kok Yen Chan, Veronique Viardot-Foucault
BACKGROUND: Antral follicle count (AFC) and anti-Mullerian hormone (AMH) are known as the most reliable markers of a woman's ovarian reserve and are related to age. There is currently no specific local age-related centile charts for AFC and AMH. Therefore, we aim to examine the relationship between AFC and AMH with age and construct age-related nomograms among a subfertile Asian population. METHODS: This is a study involving Chinese women who had their AFC and AMH measured as part of their subfertility screening from December 2010 until November 2014 in KK Women's and Children's Hospital, Singapore...
2017: PloS One
https://www.readbyqxmd.com/read/29238093/circhipk2-mediated-%C3%AF-1r-promotes-endoplasmic-reticulum-stress-in-human-pulmonary-fibroblasts-exposed-to-silica
#13
Zhouli Cao, Qingling Xiao, Xiaoniu Dai, Zewei Zhou, Rong Jiang, Yusi Cheng, Xiyue Yang, Huifang Guo, Jing Wang, Zhaoqing Xi, Honghong Yao, Jie Chao
Silicosis is characterized by fibroblast accumulation and excessive deposition of extracellular matrix. Although the roles of SiO2-induced chemokines and cytokines released from alveolar macrophages have received significant attention, the direct effects of SiO2 on protein production and functional changes in pulmonary fibroblasts have been less extensively studied. Sigma-1 receptor, which has been associated with cell proliferation and migration in the central nervous system, is expressed in the lung, but its role in silicosis remains unknown...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29233169/an-evidence-based-gamified-mhealth-intervention-for-overweight-young-adults-with-maladaptive-eating-habits-study-protocol-for-a-randomized-controlled-trial
#14
Ioana R Podina, Liviu A Fodor, Ana Cosmoiu, Rareș Boian
BACKGROUND: Cognitive behavior therapy (CBT) is the first-line of treatment for overweight and obesity patients whose problems originate in maladaptive eating habits (e.g., emotional eating). However, in-person CBT is currently difficult to access by large segments of the population. The proposed SIGMA intervention (i.e., the Self-help, Integrated, and Gamified Mobile-phone Application) is a mHealth intervention based on CBT principles. It specifically targets overweight young adults with underlying maladaptive behaviors and cognitions regarding food...
December 12, 2017: Trials
https://www.readbyqxmd.com/read/29230093/tld-and-osld-dosimetry-systems-for-remote-audits-of-radiotherapy-external-beam-calibration
#15
P Alvarez, S F Kry, F Stingo, D Followill
The Imaging and Radiation Oncology Core QA Center in Houston (IROC-H) performs remote dosimetry audits of more than 20,000 megavoltage photon and electron beams each year. Both a thermoluminescent dosimeter (TLD-100) and optically stimulated luminescent dosimeter (OSLD; nanoDot) system are commissioned for this task, with the OSLD system being predominant due to the more time-efficient read-out process. The measurement apparatus includes 3 TLD or 2 OSLD in an acrylic mini-phantom, which are irradiated by the institution under reference geometry...
November 2017: Radiation Measurements
https://www.readbyqxmd.com/read/29229460/effect-of-low-surface-tension-edta-solutions-on-the-bond-strength-of-resin-based-sealer-to-young-and-old-root-canal-dentin
#16
Cigdem Güzel, Emel Uzunoglu, Hatice Dogan Buzoglu
INTRODUCTION: The purpose of this study was to evaluate the effect of low-surface tension EDTA solutions on the push-out bond strength of resin-based sealer to young and old root canal dentin. METHODS: Root canals from 64 (n = 32 age <30 years old and n = 32 >60 years old) extracted, decoronized, single-rooted human teeth were prepared with ProTaper rotary instruments (Dentsply Maillefer, Ballaigues, Switzerland) up to size F4 using 3 mL 2.5% sodium hypochlorite (NaOCl) between each file...
December 8, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29229316/risk-adjusted-hospital-outcomes-in-elective-carotid-artery-surgery-in-patients-with-medicare
#17
Donald E Fry, Susan M Nedza, Michael Pine, Agnes M Reband, Chun-Jung Huang, Gregory Pine
BACKGROUND: The risk-adjusted outcomes by hospital of elective carotid endarterectomy that is inclusive of inpatient and 90-day postdischarge adverse outcomes have not been studied. METHODS: We studied Medicare inpatients to identify hospitals with 25 or more qualifying carotid endarterectomy cases between 2012-2014. Risk-adjusted prediction models were designed for adverse outcomes of inpatient deaths, 3-sigma prolonged duration-of-stay outliers, 90-day postdischarge deaths without readmission, and 90-day postdischarge associated readmissions...
December 8, 2017: Surgery
https://www.readbyqxmd.com/read/29226684/quantum-dot-based-luminescent-nanoprobes-for-sigma-2-receptor-imaging
#18
Maria Laura Pati, Elisabetta Fanizza, Sonja Hager, Diana Groza, Petra Heffeter, Amelita Grazia Laurenza, Valentino Laquintana, Maria Lucia Curri, Nicoletta Depalo, Carmen Abate, Nunzio Denora
The increasing importance of sigma-2 receptor as target for the diagnosis and therapy of tumours paves the way for the development of innovative optically traceable fluorescent probes as tumour cell contrast and therapeutic agents. Here, a novel hybrid organic-inorganic nanostructure is developed by combining the superior fluorescent properties of inorganic quantum dots (QDs), coated with a hydrophilic silica shell (QD@SiO2 NPs), the versatility of the silica shell and the high selectivity for sigma-2 receptors of the two synthetic ligands, namely the 6-[(6-aminohexyl)oxy]-2-(3-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3,4-dihydroisoquinolin-1(2H)-one (MLP66) and 6-[1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy]hexylamine (TA6)...
December 11, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29226483/boron-nanowheel-with-an-axle-containing-noble-gas-atoms-viable-noble-gas-bound-mb10-clusters-m-nb-ta
#19
Sudip Pan, Susmita Kar, Ranajit Saha, Edison Osorio, Ximena Zarate, Lili Zhao, Gabriel Merino, Pratim K Chattaraj
The viability of noble gas axled boron nanowheel, NgnMB10- (Ng = Ar-Rn, M = Nb, Ta; n = 1, 2), is explored via ab initio computations. In the resulting Ng2-M complexes, the Ng-M-Ng nanorod passes through the center of B10- ring, providing them with an inverse sandwich like structure. While in single Ng bound analogue, the Ng binding enthalpy (Hb) at 298 K ranges from 2.5 to 10.6 kcal/mol, in two Ng bound cases it becomes very low for Ng2MB10- -> Ng + NgMB10- dissociation channel, except for Rn case. For a given Ng, Ta has slightly higher Ng binding ability than Nb...
December 11, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29220177/-methyl-1r-2s-2-4-4-chlorophenyl-4-hydroxypiperidin-1-yl-methyl-1-phenylcyclopropanecarboxylate-mr200-derivatives-as-potent-and-selective-sigma-receptor-ligands-stereochemistry-and-pharmacological-properties
#20
Emanuele Amata, Antonio Rescifina, Orazio Prezzavento, Emanuela Arena, Maria Dichiara, Valeria Pittalà, Ángeles Montilla-García, Francesco Punzo, Pedro Merino, Enrique J Cobos, Agostino Marrazzo
Methoxycarbonyl-1-phenyl-2-cyclopropylmethyl based derivatives cis-(+)-1a [cis-(+)-MR200], cis-(-)-1a [cis-(-)-MR201], and trans-(±)-1a [trans-(±)-MR204], have been identified as new potent sigma (σ) receptor ligands. In the present paper, novel enantiomerically pure analogues were synthesized and optimized for their σ receptor affinity and selectivity. Docking studies rationalized the results obtained in the radioligand binding assay. Absolute stereochemistry was unequivocally established by X-ray analysis of precursor trans-(+)-5a as camphorsulfonyl derivative 9...
December 8, 2017: Journal of Medicinal Chemistry
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