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https://www.readbyqxmd.com/read/28210821/p-f-c-sigma-%C3%A2-cruciate-retaining-fixed-bearing-versus-mobile-bearing-knee-arthroplasty-a-prospective-comparative-study-with-minimum-10-year-follow-up
#1
O Riaz, A Aqil, G Sisodia, G Chakrabarty
AIMS: To prospectively compare long-term clinical and radiological outcomes following a cruciate retaining fixed-bearing (FB) and a mobile-bearing (MB) primary total knee replacement (TKR). METHODS: We prospectively reviewed 113 TKRs in 99 patients (14 bilateral) with a PFC sigma cruciate retaining rotating platform system, at an average follow-up of 11.1 years (range 10-12). Results were contrasted with those from 89 TKRs in 72 patients (17 bilateral) with a PFC sigma cruciate fixed-bearing prosthesis, at an average follow-up of 12...
February 16, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28210787/articular-surface-mounted-navigated-total-knee-arthroplasty-improves-the-reliability-of-component-alignment
#2
N D Clement, D MacDonald, A G Burgess, C R Howie
PURPOSE: The primary aim was to compare the early knee-specific functional outcome after articular surface mounted (ASM) navigation with non-navigated TKA. The secondary aims were to compare general physical and mental health improvement, patient satisfaction, and reliability of component alignment in the sagittal and coronal planes between ASM navigated TKA with that of non-navigated TKA. METHODS: Prospective functional outcome and radiographic data were collect for 123 patients undergoing ASM navigation and 172 patients undergoing non-navigated TKA by a high volume single surgeon...
February 16, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28190561/correlation-between-the-high-frequency-content-of-the-qrs-on-murine-surface-electrocardiogram-and-the-sympathetic-nerves-density-in-left-ventricle-after-myocardial-infarction-experimental-study
#3
Golriz Sedaghat, Ryan T Gardner, Muammar M Kabir, Elyar Ghafoori, Beth A Habecker, Larisa G Tereshchenko
Denervated post-infarct scar is arrhythmogenic. Our aim was to compare QRS frequency content in denervated and innervated left ventricular (LV) scar. In-vivo single lead ECG telemetry device was implanted in 17 heterozygous PTPσ (HET) and 7 lacking PTPσ (KO) transgenic mice. Myocardial infarction (MI) with reperfusion and sham surgery was performed. HET mice developed a denervated scar, whereas KO mice developed innervated scar. The power spectral density was used to assess the QRS frequency content. Denervated as compared to innervated post-MI scar was characterized by the higher relative contribution of 300-500Hz (14±1 vs...
February 3, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28188803/activation-of-the-sigma-1-receptor-by-haloperidol-metabolites-facilitates-brain-derived-neurotrophic-factor-secretion-from-human-astroglia
#4
Dhwanil A Dalwadi, Seongcheol Kim, John A Schetz
Glial cells play a critical role in neuronal support which includes the production and release of the neurotrophin brain-derived neurotrophic factor (BDNF). Activation of the sigma-1 receptor (S1R) has been shown to attenuate inflammatory stress-mediated brain injuries, and there is emerging evidence that this may involve a BDNF-dependent mechanism. In this report we studied S1R-mediated BDNF release from human astrocytic glial cells. Astrocytes express the S1R, which mediates BDNF release when stimulated with the prototypical S1R agonists 4-PPBP and (+)-SKF10047...
February 8, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28186787/strange-quark-magnetic-moment-of-the-nucleon-at-the-physical-point
#5
Raza Sabbir Sufian, Yi-Bo Yang, Andrei Alexandru, Terrence Draper, Jian Liang, Keh-Fei Liu
We report a lattice QCD calculation of the strange quark contribution to the nucleon's magnetic moment and charge radius. This analysis presents the first direct determination of strange electromagnetic form factors including at the physical pion mass. We perform a model-independent extraction of the strange magnetic moment and the strange charge radius from the electromagnetic form factors in the momentum transfer range of 0.051  GeV^{2}≲Q^{2}≲1.31  GeV^{2}. The finite lattice spacing and finite volume corrections are included in a global fit with 24 valence quark masses on four lattices with different lattice spacings, different volumes, and four sea quark masses including one at the physical pion mass...
January 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28176045/molecular-probes-for-imaging-the-sigma-2-receptor-in-vitro-and-in-vivo-imaging-studies
#6
Chenbo Zeng, Elizabeth S McDonald, Robert H Mach
The sigma-2 (σ2) receptor has been validated as a biomarker of the proliferative status of solid tumors. Therefore, radiotracers having a high affinity and high selectivity for σ2 receptors have the potential to assess the proliferative status of human tumors using noninvasive imaging techniques such as Positron Emission Tomography (PET). Since the σ2 receptor has not been cloned, the current knowledge of this receptor has relied on receptor binding studies with the radiolabeled probes and investigation of the effects of the σ2 receptor ligands on tumor cells...
February 8, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28172705/dop088-somatic-and-visceral-hypersensitivity-associated-to-acute-intestinal-inflammation-are-absent-in-sigma-1-receptor-knockout-mice
#7
S Lόpez-Estévez, G Gris, B de la Puente, X Codony, M Merlos, V Martínez
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172547/p033-dss-induced-colitis-is-attenuated-in-sigma-1-receptor-knockout-mice
#8
S Lόpez-Estévez, M Aguilera, G Gris, B de la Puente, X Codony, D Zamanillo, V Martínez
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28164511/application-of-six-sigma-model-to-evaluate-the-analytical-quality-of-four-hba1c-analyzers
#9
Jos Eacute M Maesa, Patricia Fern Aacute Ndez-Riejos, Catalina S Aacute Nchez-Mora, Mar Iacute A De Toro-Crespo, Concepci Oacute N Gonz Aacute Lez-Rodriguez
BACKGROUND: The Six Sigma Model is a global quality management system applicable to the determination of glycated hemoglobin (HbA1c). In addition, this model can ensure the three characteristics influencing the patient risk: the correct performance of the analytical method with low inaccuracy and bias, the quality control strategy used by the laboratory, and the necessary quality of the analyte. The aim of this study is to use the Six Sigma Model for evaluating quality criteria in the determination of glycated hemoglobin HbA1c and its application to assess four different HbA1c analyzers...
January 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28153289/on-line-automated-system-for-the-determination-of-sb-v-sb-iii-thrimethyl-antimony-v-and-total-antimony-in-soil-employing-multisyringe-flow-injection-analysis-coupled-to-hg-afs
#10
Mario M Silva Junior, Lindomar A Portugal, Antonio M Serra, Laura Ferrer, Victor Cerdà, Sergio L C Ferreira
This paper proposes the use of a multisyringe flow injection analysis (MSFIA) system for inorganic antimony speciation analysis, trimethyl antimony(V) and determination of total antimony in soil samples using hydride generation atomic fluorescence spectrometry (HG-AFS). Total antimony has been determined after reduction of antimony(V) to antimony(III) using potassium iodide and ascorbic acid. For determination of total inorganic antimony the sample is percolated in a mini-column containing the Dowex 50W-X8 resin for retention of the organic species of antimony...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28152184/analytic-and-quality-control-validation-and-assessment-of-field-performance-of-a-point-of-care-chemistry-analyzer-for-use-in-the-white-rhinoceros
#11
Emma H Hooijberg, Gerhard Steenkamp, Jacques P du Preez, Amelia Goddard
BACKGROUND: A chemistry point-of-care analyzer would be useful for evaluating injured wildlife, particularly White rhinoceros (Ceratotherium simum) that survive poaching attempts. The IDEXX VetTest could be suitable, but species-specific validation, development of a statistical quality control (QC) strategy, and evaluation under field conditions are necessary. OBJECTIVES: The objectives were to (1) validate the VetTest for the White rhinoceros, (2) perform QC validation on the VetTest and generate a statistical QC strategy, and (3) apply this QC strategy to monitor performance under typical field conditions...
February 2, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28149022/application-of-sigma-metrics-analysis-for-the-assessment-and-modification-of-quality-control-program-in-the-clinical-chemistry-laboratory-of-a-tertiary-care-hospital
#12
Sahar Iqbal, Tazeen Mustansar
Sigma is a metric that quantifies the performance of a process as a rate of Defects-Per-Million opportunities. In clinical laboratories, sigma metric analysis is used to assess the performance of laboratory process system. Sigma metric is also used as a quality management strategy for a laboratory process to improve the quality by addressing the errors after identification. The aim of this study is to evaluate the errors in quality control of analytical phase of laboratory system by sigma metric. For this purpose sigma metric analysis was done for analytes using the internal and external quality control as quality indicators...
March 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28144920/the-impact-of-a-single-nucleotide-polymorphism-in-sigmar1-on-depressive-symptoms-in-major-depressive-disorder-and-bipolar-disorder
#13
Laura Mandelli, Sheng-Min Wang, Changsu Han, Soo-Jung Lee, Ashwin A Patkar, Prakash S Masand, Chi-Un Pae, Alessandro Serretti
INTRODUCTION: Ample evidence suggested a role of sigma-1 receptor in affective disorders since the interaction of numerous antidepressants with sigma receptors was discovered. A recent study on Japanese subjects found a genetic variant within the encoding gene SIGMAR1 (rs1800866A>C) associated with major depressive disorder (MDD). We aimed to evaluate the same polymorphism in both MDD and bipolar disorder (BD) as well as its relationship to response to treatment with antidepressants and mood stabilizers...
January 31, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28144220/exploring-drug-receptor-interaction-kinetics-lessons-from-a-sigma-1-receptor-transmembrane-biosensor
#14
Víctor Fernández-Dueñas, Javier Burgueño, Francisco Ciruela
No abstract text is available yet for this article.
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28142345/total-knee-arthroplasty-conversion-for-patients-with-ankylosed-knees
#15
Hee-June Kim, Jong-Uk Mun, Kwang-Hwan Kim, Hee-Soo Kyung
INTRODUCTION: The purpose of this study was to evaluate the results of total knee arthroplasty for patients with ankylosed knees. METHODS: We evaluated seven patients (10 knees) who underwent total knee arthroplasties for ankylosed knees from 1995 to 2008. There were two men and five women, with a mean age of 44.1 years (42-48 years). The mean follow-up period was 10.2 years (1-19.5 years). A rectus snip was performed in all cases, and V-Y quadricepsplasty was used in one case of severe quadriceps contracture...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28135101/design-and-investigation-of-a-18f-labeled-benzamide-derivative-as-a-high-affinity-dual-sigma-receptor-subtype-radioligand-for-prostate-tumor-imaging
#16
Dongzhi Yang, Anthony Comeau, Wayne D Bowen, Robert H Mach, Brian D Ross, Hao Hong, Marcian E Van Dort
High overexpression of sigma (σ) receptors (σ1 and σ2 subtypes) in a variety of human solid tumors has prompted the development of σ receptor-targeting radioligands, as imaging agents for tumor detection. A majority of these radioligands to date, target the σ2 receptor, a potential marker of tumor proliferative status. The identification of approximately equal proportions of both σ receptor subtypes in prostate tumors, suggests that a high affinity, dual σ receptor-targeting radioligand could potentially provide enhanced tumor targeting efficacy in prostate cancer...
January 30, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28133984/new-arylsparteine-derivatives-as-positive-inotropic-drugs
#17
Vito Boido, Marcella Ercoli, Michele Tonelli, Federica Novelli, Bruno Tasso, Fabio Sparatore, Elena Cichero, Paola Fossa, Paola Dorigo, Guglielmina Froldi
Positive inotropic agents are fundamental in the treatment of heart failure; however, their arrhythmogenic liability and the increased myocardial oxygen demand strongly limit their therapeutic utility. Pursuing our study on cardiovascular activities of lupin alkaloid derivatives, several 2-(4-substituted-phenyl)-2-dehydrosparteines and 2-(4-substituted-phenyl)sparteines were prepared and tested for inotropic and chronotropic activities on isolated guinea pig atria. Four compounds (6b, 6e, 7b, and 7f) exhibited significant inotropism that, at the higher concentrations, was followed by negative inotropism or toxicity...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28129990/chiral-resolution-of-serial-potent-and-selective-%C3%AF-1-ligands-and-biological-evaluation-of-18-f-tz3108-in-rodent-and-the-nonhuman-primate-brain
#18
Xuyi Yue, Hongjun Jin, Zonghua Luo, Hui Liu, Xiang Zhang, Ethan D McSpadden, Linlin Tian, Hubert P Flores, Joel S Perlmutter, Stanley M Parsons, Zhude Tu
Twelve optically pure enantiomers were obtained using either crystallization or chiral high performance liquid chromatography (HPLC) separation methodologies to resolve six racemic sigma-1 (σ1) receptor ligands. The in vitro binding affinities of each enantiomer for σ1, σ2 receptors and vesicular acetylcholine transporter (VAChT) were determined. Out of the 12 optically pure enantiomers, five displayed very high affinities for σ1 (Ki<2nM) and high selectivity for σ1 versus σ2 and VAChT (>100-fold)...
February 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28125455/the-role-of-accountable-care-organization-affiliation-and-ownership-in-promoting-physician-practice-participation-in-quality-improvement-collaboratives
#19
Vanessa B Hurley, Hector P Rodriguez, Stephen M Shortell
BACKGROUND: Quality improvement collaboratives (QICs) have emerged as an important strategy to improve processes and outcomes of clinical care through interorganizational learning. Little is known about the organizational factors that support or deter physician practice participation in QICs. PURPOSE: The aim of this study was to examine organizational influences on physician practices' propensity to participate in QICs. We hypothesized that practice affiliation with an accountable care organization (ACO) and practice ownership by a system or community health center (CHC) would increase the propensity of physician practices to participate in a QIC...
January 25, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28123452/s2rsldb-a-comprehensive-manually-curated-internet-accessible-database-of-the-sigma-2-receptor-selective-ligands
#20
Giovanni Nastasi, Carla Miceli, Valeria Pittalà, Maria N Modica, Orazio Prezzavento, Giuseppe Romeo, Antonio Rescifina, Agostino Marrazzo, Emanuele Amata
BACKGROUND: Sigma (σ) receptors are accepted as a particular receptor class consisting of two subtypes: sigma-1 (σ1) and sigma-2 (σ2). The two receptor subtypes have specific drug actions, pharmacological profiles and molecular characteristics. The σ2 receptor is overexpressed in several tumor cell lines, and its ligands are currently under investigation for their role in tumor diagnosis and treatment. The σ2 receptor structure has not been disclosed, and researchers rely on σ2 receptor radioligand binding assay to understand the receptor's pharmacological behavior and design new lead compounds...
2017: Journal of Cheminformatics
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