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https://www.readbyqxmd.com/read/27910870/antinociceptive-profile-of-levo-tetrahydropalmatine-in-acute-and-chronic-pain-mice-models-role-of-spinal-sigma-1-receptor
#1
Dong-Wook Kang, Ji-Young Moon, Jae-Gyun Choi, Suk-Yun Kang, Yeonhee Ryu, Jin Bong Park, Jang-Hern Lee, Hyun-Woo Kim
We have recently reported that repeated systemic treatments of extract from Corydalis yanhusuo alleviate neuropathic pain and levo-tetrahydropalmatine (l-THP) is one of active components from Corydalis. We designed this study to investigate antinociceptive effect of l-THP in acute and chronic pain models and related mechanism within the spinal cord. We found that intraperitoneal pretreatment with l-THP significantly inhibited the second phase of formalin-induced pain behavior. In addition, intrathecal as well as intraperitoneal pretreatment with l-THP reduced the mechanical allodynia (MA) induced by direct activation of sigma-1 receptor (Sig-1)...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905666/spectral-electroencephalography-profile-of-rapid-eye-movement-sleep-at-sleep-onset-in-narcolepsy-type-1
#2
F Pizza, R Ferri, S Vandi, F Rundo, M Iloti, G Neccia, G Plazzi
BACKGROUND AND PURPOSE: The sleep-onset rapid eye movement (REM) period (SOREMP), the hallmark of narcolepsy, may be a specific state and not the simple anticipation of REM sleep. METHODS: We analyzed the electroencephalographic spectral content in untreated patients with narcolepsy type 1 (NT1) during the sleep-onset period (SOP) and during nocturnal REM sleep in two consecutive nocturnal recordings from 31 patients with NT1 (mean age 34 ± 15 years, 18 males) and a single nocturnal recording from 36 controls (mean age 38 ± 13 years, 21 males)...
December 1, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27900790/revealing-germylene-compounds-to-attain-superbasicity-with-sigma-donor-substituents-a-density-functional-theory-study
#3
Bishwajit Ganguly, Abul Kalam Biswas
This study reports for the first time that compounds of Ge (II) can function as superbases. Two B(N=PiPr3)2 groups attached to a germanium (II) center show a gas phase proton affinity of 296.2 kcal/mol, close to the range of a hyperbase as revealed by B3LYP-D3/6-31G(2d,p) level of theory. These DFT calculations showed better agreement of geometrical parameters for the reported stable germylene compound 1 than previously reported calculations at the B3LYP/6-31G(2d,p) and PBE/DZP level of theory. A systematic study performed with different substitutions of Ge(II) revealed that such system can achieve basicity close to a hyperbase...
November 30, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27895516/a-prospective-observational-study-comparing-the-pk-pd-relationships-of-generic-meropenem-mercide-%C3%A2-to-the-innovator-brand-in-critically-ill-patients
#4
Mervyn Mer, Jacques Rene Snyman, Constance Elizabeth Jansen van Rensburg, Jacob John van Tonder, Ilze Laurens
INTRODUCTION: Clinicians' skepticism, fueled by evidence of inferiority of some multisource generic antimicrobial products, results in the underutilization of more cost-effective generics, especially in critically ill patients. The aim of this observational study was to demonstrate equivalence between the generic or comparator brand of meropenem (Mercide(®)) and the leading innovator brand (Meronem(®)) by means of an ex vivo technique whereby antimicrobial activity is used to estimate plasma concentration of the active moiety...
2016: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/27886264/sigma-1-receptor-agonism-promotes-mechanical-allodynia-after-priming-the-nociceptive-system-with-capsaicin
#5
J M Entrena, C Sánchez-Fernández, F R Nieto, R González-Cano, S Yeste, E J Cobos, J M Baeyens
Sigma-1 receptor antagonists promote antinociception in several models of pain, but the effects of sigma-1 agonists on nociception (particularly when the nociceptive system is primed) are not so well characterized; therefore we evaluated the effects of sigma-1 agonists on pain under different experimental conditions. The systemic administration of the selective sigma-1 agonists (+)-pentazocine and PRE-084, as well as the nonselective sigma-1 agonist carbetapentane (used clinically as an antitussive drug), did not alter sensitivity to mechanical stimulation under baseline conditions...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27885719/targeting-nanocarriers-with-anisamide-fact-or-artifact
#6
Athanasia Dasargyri, Carole D Kümin, Jean-Christophe Leroux
Encapsulating chemotherapeutics in nanoparticles can reduce the side effects of intravenous administration and improve their antitumor efficacy. Additionally, surface decoration of the nanocarriers with tumor-targeting ligands may enhance their specificity for cancer cells overexpressing the corresponding ligand-binding counterpart. The focus here is on anisamide, a low-molecular-weight benzamide derivative used as a tumor-directing moiety in functionalized nanosystems, based on its alleged interaction with Sigma receptors...
November 25, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27878231/sirt1-exerts-neuroprotective-effects-by-attenuating-cerebral-ischemia-reperfusion-induced-injury-via-targeting-p53-microrna-22
#7
Hui Lu, Bincheng Wang
The aim of this study was to investigate whether the SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury (CIRI) via targeting p53/microRNA-22. We found that the overexpression of sirtuin 1 (SIRT1) decreased the infarct volume, suppressed p53 protein expression and activated microRNA-22 expression following CIRI. An injection of lipopolysaccharide (LPS, 1 mg/ml; Sigma, St. Louis, MO USA) into the corpus callosum was used to induce CIRI in rats. The infarct volume and neurological deficit score were used to examine the effects of SIRT1 on CIRI...
November 18, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27865495/assessment-of-multifunctional-activity-of-bioactive-peptides-derived-from-fermented-milk-by-specific-lactobacillus-plantarum-strains
#8
J E Aguilar-Toalá, L Santiago-López, C M Peres, C Peres, H S Garcia, B Vallejo-Cordoba, A F González-Córdova, A Hernández-Mendoza
Milk-derived bioactive peptides with a single activity (e.g., antioxidant, immunomodulatory, or antimicrobial) have been previously well documented; however, few studies describe multifunctional bioactive peptides, which may be preferred over single-activity peptides, as they can simultaneously trigger, modulate, or inhibit multiple physiological pathways. Hence, the aim of this study was to assess the anti-inflammatory, antihemolytic, antioxidant, antimutagenic, and antimicrobial activities of crude extracts (CE) and peptide fractions (<3 and 3-10 kDa) obtained from fermented milks with specific Lactobacillus plantarum strains...
November 16, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27862689/applying-lean-six-sigma-methodology-to-reduce-cesarean-section-rate
#9
Ze-Ying Chai, Hua-Min Hu, Xiu-Ling Ren, Bao-Jin Zeng, Ling-Zhi Zheng, Feng Qi
OBJECTIVES: This study aims to reduce cesarean section rate and increase rate of vaginal delivery. METHODS: By using Lean Six Sigma (LSS) methodology, the cesarean section rate was investigated and analyzed through a 5-phase roadmap consisting of Define, Measure, Analyze, Improve, and Control. The principal causes of cesarean section were identified, improvement measures were implemented, and the rate of cesarean section before and after intervention was compared...
November 14, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27857729/sigma-1-receptor-and-neuroprotection-current-outlook-and-potential-therapeutic-effects
#10
Giovanni Li Volti, Paolo Murabito
No abstract text is available yet for this article.
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27856693/construction-of-lambda-mu-sigma-values-for-determining-mid-upper-arm-circumference-z-scores-in-u-s-children-aged-2-months-through-18-years
#11
Susan M Abdel-Rahman, Charlie Bi, Kristi Thaete
BACKGROUND: Mid-upper arm circumference (MUAC) has proven highly predictive of morbidity and mortality associated with malnutrition better, in some cases, than other growth indicators, including body mass index (BMI) z scores and weight-for-height z scores. A recent consensus statement recommended the inclusion of MUAC and MUAC z scores in the nutrition assessment of children in the United States; however, the requisite data to permit z score calculations for children aged >5 years have not been published...
November 17, 2016: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/27851908/n-phenylpropyl-n-substituted-piperazines-occupy-sigma-receptors-and-alter-methamphetamine-induced-hyperactivity-in-mice
#12
Dennis K Miller, Eric S Park, Susan Z Lever, John R Lever
This study examined the effect of the N-phenylpropyl-N'-substituted piperazine ligands SA4503 (3.4-dimethoxyphenethyl), YZ-067 (4-methoxyphenethyl), YZ-185 (3-methoxyphenethyl) and Nahas-3h (4-methoxybenzyl) on methamphetamine-induced hyperactivity in mice. In a previous study in rats, SA4503 increased methamphetamine-induced hyperactivity at a lower ligand dose and enhanced it at a higher dose. The other ligands have not been investigated in this assay. Presently, mice were administered sigma ligands, and specific [(125)I]E-IA-DM-PE-PIPZE and [(125)I]RTI-121 binding was measured to determine σ1 sigma receptor and dopamine transporter occupancy, respectively...
November 13, 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/27844108/transcriptional-responses-of-the-bacterium-burkholderia-terrae-bs001-to-the-fungal-host-lyophyllum-sp-strain-karsten-under-soil-mimicking-conditions
#13
Irshad Ul Haq, Francisco Dini-Andreote, Jan Dirk van Elsas
In this study, the mycosphere isolate Burkholderia terrae BS001 was confronted with the soil fungus Lyophyllum sp. strain Karsten on soil extract agar plates in order to examine its transcriptional responses over time. At the initial stages of the experiment (T1-day 3; T2-day 5), contact between both partner organisms was absent, whereas in the final stage (T3-day 8), the two populations made intimate physical contact. Overall, a strong modulation of the strain BS001 gene expression patterns was found. First, the stationary-phase sigma factor RpoS, and numerous genes under its control, were strongly expressed as a response to the soil extract agar, and this extended over the whole temporal regime...
November 14, 2016: Microbial Ecology
https://www.readbyqxmd.com/read/27829319/effect-of-different-concentrations-of-oxygen-on-expression-of-sigma-1-receptor-and-superoxide-dismutases-in-human-colon-adenocarcinoma-cell-lines
#14
Michał Skrzycki, Hanna Czeczot, Magdalena Mielczarek-Puta, Dagmara Otto-Ślusarczyk, Wojciech Graboń
CONTEXT: Tumor cells due to distance from capillary vessels exist in different oxygenation conditions (anoxia, hypoxia, normoxia). Changes in cell oxygenation lead to reactive oxygen species production and oxidative stress. Sigma 1 receptor (Sig1R) is postulated to be stress responding agent and superoxide dismutases (SOD1 and SOD2) are key antioxidant enzymes. It is possible that they participate in tumor cells adaptation to different concentrations of oxygen. OBJECTIVE: Evaluation of Sig1R, SOD1, and SOD2 expression in different concentrations of oxygen (1%, 10%, 21%) in colon adenocarcinoma cell lines...
November 9, 2016: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/27821430/mitochondria-associated-membrane-collapse-is-a-common-pathomechanism-in-sigmar1-and-sod1-linked-als
#15
Seiji Watanabe, Hristelina Ilieva, Hiromi Tamada, Hanae Nomura, Okiru Komine, Fumito Endo, Shijie Jin, Pedro Mancias, Hiroshi Kiyama, Koji Yamanaka
A homozygous mutation in the gene for sigma 1 receptor (Sig1R) is a cause of inherited juvenile amyotrophic lateral sclerosis (ALS16). Sig1R localizes to the mitochondria-associated membrane (MAM), which is an interface of mitochondria and endoplasmic reticulum. However, the role of the MAM in ALS is not fully elucidated. Here, we identified a homozygous p.L95fs mutation of Sig1R as a novel cause of ALS16. ALS-linked Sig1R variants were unstable and incapable of binding to inositol 1,4,5-triphosphate receptor type 3 (IP3R3)...
December 1, 2016: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/27818324/the-sigma-1-receptor-mediates-the-beneficial-effects-of-pridopidine-in-a-mouse-model-of-huntington-disease
#16
Daniel Ryskamp, Jun Wu, Michal Geva, Rebecca Kusko, Iris Grossman, Michael Hayden, Ilya Bezprozvanny
The tri-nucleotide repeat expansion underlying Huntington disease (HD) results in corticostriatal synaptic dysfunction and subsequent neurodegeneration of striatal medium spiny neurons (MSNs). HD is a devastating autosomal dominant disease with no disease-modifying treatments. Pridopidine, a postulated "dopamine stabilizer", has been shown to improve motor symptoms in clinical trials of HD. However, the target(s) and mechanism of action of pridopidine remain to be fully elucidated. As binding studies identified sigma-1 receptor (S1R) as a high-affinity receptor for pridopidine, we evaluated the relevance of S1R as a therapeutic target of pridopidine in HD...
November 3, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27812412/in-silico-study-on-anti-chikungunya-virus-activity-of-hesperetin
#17
Adrian Oo, Pouya Hassandarvish, Sek Peng Chin, Vannajan Sanghiran Lee, Sazaly Abu Bakar, Keivan Zandi
BACKGROUND: The re-emerging, Aedes spp. transmitted Chikungunya virus (CHIKV) has recently caused large outbreaks in a wide geographical distribution of the world including countries in Europe and America. Though fatalities associated with this self-remitting disease were rarely reported, quality of patients' lives have been severely diminished by polyarthralgia recurrence. Neither effective antiviral treatment nor vaccines are available for CHIKV. Our previous in vitro screening showed that hesperetin, a bioflavonoid exhibits inhibitory effect on the virus intracellular replication...
2016: PeerJ
https://www.readbyqxmd.com/read/27810787/pharmacological-importance-of-sulphated-polysaccharide-carrageenan-from-red-seaweed-kappaphycus-alvarezii-in-comparison-with-commercial-carrageenan
#18
Arumugampillai Manimehalai Suganya, Muthusamy Sanjivkumar, Manohar Navin Chandran, Arunachalam Palavesam, Grasian Immanuel
Pharmacological properties of native carrageenan (κ) extracted from Kappaphycus alvarezii and commercial carrageenan (Sigma-Aldrich) were evaluated using in vitro antioxidant, anticancer and antidiabetic studies. Phytochemical analysis of native and commercial carrageenans showed the presence of alkaloids, saponins, steroids, gums & mucilages and carbohydrate. Both native and commercial carrageenans exhibited better antioxidant activities such as total antioxidant capacity (87±0.47 and 82.6±0.47μg A.A/g), hydroxyl radical scavenging activity (61...
October 28, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27809529/spin-delocalization-in-a-helical-open-shell-hydrocarbon
#19
Prince Ravat, Peter Ribar, Michel Rickhaus, Daniel Häussinger, Markus Neuburger, Michal Juricek
Neutral open-shell molecules, in which spin density is delocalized through a helical conjugated backbone, hold promise as models for investigating phenomena arising from the interplay of magnetism and chirality. Apart from a handful of examples, however, the chemistry of these compounds remains largely unexplored. Here, we examine the prospect of extending spin-delocalization over a helical backbone in a model compound naphtho[3,2,1-no]tetraphene, the first helically chiral open-shell hydrocarbon, in which one benzene ring is fused to [5]helicene, forming a phenalenyl subunit...
November 3, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27788206/full-genome-sequencing-and-confirmation-of-the-causative-agent-of-erythrocytic-inclusion-body-syndrome-in-coho-salmon-identifies-a-new-type-of-piscine-orthoreovirus
#20
Tomokazu Takano, Akatsuki Nawata, Takamitsu Sakai, Tomomasa Matsuyama, Takafumi Ito, Jun Kurita, Sachiko Terashima, Motoshige Yasuike, Yoji Nakamura, Atushi Fujiwara, Akira Kumagai, Chihaya Nakayasu
Erythrocytic inclusion body syndrome (EIBS) causes mass mortality in farmed salmonid fish, including the coho salmon, Onchorhynchus kisutchi, and chinook salmon, O. tshawytscha. The causative agent of the disease is a virus with an icosahedral virion structure, but this virus has not been characterized at the molecular level. In this study, we sequenced the genome of a virus purified from EIBS-affected coho salmon. The virus has 10 dsRNA genomic segments (L1, L2, L3, M1, M2, M3, S1, S2, S3, and S4), which closely resembles the genomic organization of piscine orthoreovirus (PRV), the causative agent of heart and skeletal inflammation (HSMI) in Atlantic salmon and HSMI-like disease in coho salmon...
2016: PloS One
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