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https://www.readbyqxmd.com/read/28549166/acute-granulomatous-hepatitis-in-an-immunosuppressed-patient-secondary-to-q-fever
#1
Alaa Alakkari, Roisin Stack, Vikrant Parihar, Stephen Crowther, Barbara Ryan
No abstract text is available yet for this article.
May 26, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28546336/the-value-of-18-f-fdg-pet-ct-in-diagnosis-and-during-follow-up-in-273-patients-with-chronic-q-fever
#2
Ilse Kouijzer, Linda Kampschreur, Peter Wever, Corneline Hoekstra, Marjo van Kasteren, Monique de Jager-Leclercq, Marrigje Nabuurs-Franssen, Marjolijn Wegdam-Blans, Heidi Ammerlaan, Jacqueline Buijs, Lioe-Fee de Geus-Oei, Wim Oyen, Chantal Bleeker-Rovers
In 1-5% of all acute Q fever infections, chronic Q fever develops, mostly manifesting as endocarditis, infected aneurysms, or infected vascular prostheses. In this study, we investigated the diagnostic value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) in chronic Q fever at diagnosis and during follow-up. Methods: All Dutch adult patients suspected of chronic Q fever who were diagnosed since 2007 were retrospectively included until March 2015 when at least one (18)F-FDG-PET/CT was performed...
May 25, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28545666/mahuannin-b-an-adenylate-cyclase-inhibitor-attenuates-hyperhidrosis-via-suppressing-%C3%AE-2-adrenoceptor-camp-signaling-pathway
#3
Zengyong Wang, Yu Cui, Guoyu Ding, Mengge Zhou, Xiaoyao Ma, Yuanyuan Hou, Min Jiang, Dailin Liu, Gang Bai
BACKGROUND: Based on the traditional application of traditional Chinese Medicines (TCMs), Ephedra Herba (EH) is used to cure cold fever by inducing sweating, whereas Ephedra Radix (ER) is used to treat hyperhidrosis. Although they come from the same plant, Ephedra sinica Stapf, but have play opposing roles in clinical applications. EH is known to contain ephedrine alkaloids, which is the driver of the physiological changes in sweating, heart rate and blood pressure. However, the active pharmacological ingredients (APIs) of ER and the mechanisms by which it restricts sweating remain unknown...
July 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28540258/horizontally-acquired-biosynthesis-genes-boost-coxiella-burnetii-s-physiology
#4
Abraham S Moses, Jess A Millar, Matteo Bonazzi, Paul A Beare, Rahul Raghavan
Coxiella burnetii, the etiologic agent of acute Q fever and chronic endocarditis, has a unique biphasic life cycle, which includes a metabolically active intracellular form that occupies a large lysosome-derived acidic vacuole. C. burnetii is the only bacterium known to thrive within such an hostile intracellular niche, and this ability is fundamental to its pathogenicity; however, very little is known about genes that facilitate Coxiella's intracellular growth. Recent studies indicate that C. burnetii evolved from a tick-associated ancestor and that the metabolic capabilities of C...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28520862/q-fever-confusion-between-chronic-infection-and-chronic-fatigue
#5
Didier Raoult
No abstract text is available yet for this article.
May 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28502643/are-brucellosis-q-fever-and-melioidosis-potential-causes-of-febrile-illness-in-madagascar
#6
Ides Boone, Klaus Henning, Angela Hilbert, Heinrich Neubauer, Vera von Kalckreuth, Denise Myriam Dekker, Norbert Georg Schwarz, Gi Deok Pak, Andreas Krüger, Ralf Matthias Hagen, Hagen Frickmann, Jean Noël Heriniaina, Raphael Rakotozandrindrainy, Jean Philibert Rakotondrainiarivelo, Tsiry Razafindrabe, Benedikt Hogan, Jürgen May, Florian Marks, Sven Poppert, Sascha Al Dahouk
Brucellosis, Q fever and melioidosis are zoonoses, which can lead to pyrexia. These diseases are often under-ascertained and underreported because of their unspecific clinical signs and symptoms, insufficient awareness by physicians and public health officers and limited diagnostic capabilities, especially in low-resource countries. Therefore, the presence of Brucella spp., Coxiella burnetii and Burkholderia pseudomallei was investigated in Malagasy patients exhibiting febrile illness. In addition, we analyzed zebu cattle and their ticks as potential reservoirs for Brucella and C...
May 11, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28496435/serum-metabolomic-profiling-of-piglets-infected-with-virulent-classical-swine-fever-virus
#7
Wenjie Gong, Junjie Jia, Bikai Zhang, Shijiang Mi, Li Zhang, Xiaoming Xie, Huancheng Guo, Jishu Shi, Changchun Tu
Classical swine fever (CSF) is a highly contagious swine infectious disease and causes significant economic losses for the pig industry worldwide. The objective of this study was to determine whether small molecule metabolites contribute to the pathogenesis of CSF. Birefly, serum metabolomics of CSFV Shimen strain-infected piglets were analyzed by ultraperformance liquid chromatography/electrospray ionization time-of-flight mass spectrometry (UPLC/ESI-Q-TOF/MS) in combination with multivariate statistical analysis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28484683/alterations-of-the-coxiella-burnetii-replicative-vacuole-membrane-integrity-and-interplay-with-the-autophagy-pathway
#8
María E Mansilla Pareja, Antonino Bongiovanni, Frank Lafont, María I Colombo
Coxiella burnetii, the etiologic agent of Q fever, is a Gram-negative obligate intracellular bacterium. It has been previously described that both the endocytic and autophagic pathways contribute to the Coxiella replicative vacuole (CRV) generation. Galectins are β-galactoside-binding lectins that accumulate in the cytosol before being secreted via a non-conventional secretory pathway. It has been shown that Galectin-3, -8, -9 monitor bacteria vacuolar rupture and endosomal and lysosomal loss of membrane integrity through binding of host glycans exposed in the cytoplasm after membrane damage...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28482392/-three-cases-with-familial-mediterranean-fever-misdiagnosed-as-juvenile-idiopathic-arthritis
#9
J Li, Y Zhang, W Wang, L Q Zhong, H M Song
Objective: To explore the key points of diagnosis and treatment of familial Mediterranean fever(FMF). Method: The clinical data of 3 cases with FMF misdiagnosed as Juvenile idiopathic arthritis(JIA)seen from January 2014 to June 2016 in Peking Union Medical College Hospital were retrospectively collected. The clinical manifestations, gene mutation characteristics, treatment and prognosis were also evaluated. Result: Two cases were male and 1 was female. The mean age of onset was 17 months (3 months to 36 months), while the average age of diagnosis was 6 years and 8 months (24 months to 11 years)...
May 4, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28482385/-a-multicenter-randomized-controlled-study-of-saccharomyces-boulardii-in-the-prevention-of-antibiotic-associated-diarrhea-in-infants-and-young-children
#10
C M Wan, H Yu, G Liu, H M Xu, Z Q Mao, Y Xu, Y Jin, R P Luo, W J Wang, F Fang
Objective: To evaluate the efficacy and safety of Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea (AAD) in infants and young children. Method: From November 2012 to September 2013, ten research units of large teaching hospitals or children's hospitals participated in this multicenter randomized controlled clinical trial. Hospitalized young children aged between 1 month and 3 years (nongastrointestinal infection and antibiotic therapy required)were involved in our study. The children were randomly divided into control group and prevention group by means of block random allocation method...
May 4, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28480664/clinical-and-genetic-features-of-coxiella-burnetii-in-a-patient-with-an-acute-febrile-illness-in-korea
#11
Seung Hun Lee, Jung Yeon Heo, Hae Kyung Lee, Yeong Seon Lee, Hye Won Jeong, Seon Do Hwang
Although Q fever is an important zoonotic infection with a worldwide distribution, no human isolates of Coxiella burnetii have been identified in Korea. For the first time, we identified the nucleotide sequence of C. burnetii from a 32-year-old man with an acute febrile illness in Korea. Diagnosis of acute Q fever was confirmed by seroconversion using indirect immunofluorescence antibody assays. Phylogenetic analysis demonstrated high sequence similarity (99.6%-100%) with C. burnetii 16S rRNA sequences identified from the reservoir...
June 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28479768/laparoscopic-sacrocolpopexy-using-barbed-sutures-for-mesh-fixation-and-peritoneal-closure-a-safe-option-to-reduce-operational-times
#12
Panagiotis Kallidonis, Abdulrahman Al-Aown, Marinos Vasilas, Iason Kyriazis, Vasilis Panagopoulos, Fotini Fligou, Anastasios Athanasopoulos, Bagheri Fariborz, Evangelos Liatsikos, Mehmet Özsoy
INTRODUCTION: Laparoscopic sacrocolpopexy (LSC) has established itself as a safe method for the management of pelvic organ prolapse (POP). Laparoscopic suturing is a time-consuming intraoperative task during LSC. Self-retaining barbed sutures (SBSs) are known to reduce the operative time in laparoscopic cases. The current study aimed to evaluate the efficacy and safety of SBS during the performance of LSC. MATERIALS AND METHODS: Twenty female patients with symptomatic POP were treated with LSC by an expert surgeon...
April 2017: Urology Annals
https://www.readbyqxmd.com/read/28468073/-characteristics-on-the-onset-features-of-scarlet-fever-in-beijing-2006-2015
#13
S S Wu, C N Ma, X M Peng, D T Zhang, Q Y Wang, P Yang
Objective: This study aimed to explore the incidence trends and onset features of scarlet fever during the years of epidemic, from 2006 to 2015, in Beijing. Methods: Spatial, temporal and population distributions, prognosis of the reported cases and surveillance data on scarlet fever and other streptococcal infections (including the patients of streptococcal infection, tonsillitis and isthmitis) were analyzed by the descriptive epidemiological methods. Results: A total of 27 987 scarlet fever cases were reported from 2006 to 2015, with the incidence rates as 7...
April 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28464594/-analysis-on-the-performance-evaluation-of-the-global-fund-malaria-programme-in-china-from-2003-to-2013
#14
Q F Zhang, R B Wang, B Zheng, Z G Xia, S S Zhou
Objective: To analyze the performance of the 5 Global Fund Malaria Programmes in China from 2003 to 2013. Methods: All of the proposals, summaries, progress reports, survey reports, Monitoring& Evaluation reports, and performance rating reports of the 5 Global Fund Malaria Programmes in China and the epidemic data of program areas were collected for statistical analysis from 2012 to 2014. Symposiums were held with relevant experts from national and provincial Centers for Disease Control and Prevention, program managers and staffs from national and provincial Global Fund Malaria Programme offices...
May 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28462725/coxiella-burnetii-q-fever-infection-in-dairy-cattle-and-associated-risk-factors-in-latvia
#15
A Boroduske, J Trofimova, J Kibilds, U Papule, M Sergejeva, I Rodze, L Grantina-Ievina
The purpose of this study was to describe prevalence and spatial distribution of Coxiella burnetii infections in dairy cow sheds in Latvia and to investigate risk factors contributing to C. burnetii infections. Blood serum samples from abortion cases from 1010 sheds have been tested by ELISA for the presence of C. burnetii antibodies and bulk tank milk (BTM) samples from 252 sheds have been tested by real time polymerase chain reaction and ELISA for the presence of C. burnetii DNA and antibodies. Prevalence of C...
May 2, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28455328/coxiella-burnetii-circulation-in-a-naturally-infected-flock-of-sheep-individual-follow-up-of-antibodies-in-serum-and-milk
#16
A Joulié, E Rousset, P Gasqui, E Lepetitcolin, A Leblond, K Sidi-Boumedine, E Jourdain
The control of Q fever, a zoonotic disease caused by the Coxiella burnetii bacterium, remains a scientific challenge. Domestic ruminants are considered the main reservoir, shedding C. burnetii essentially through parturition products during abortion or birth. Sheep are particularly frequently associated with human outbreaks, but there are insufficient field data to fully understand disease dynamics and instigate efficient control measures.A longitudinal follow-up study of a naturally infected sheep flock was performed in order to: (a) investigate relationships between seropositivity and bacterial shedding in the vaginal mucus, (b) describe the kinetics of antibodies, including responses to vaccination, (c) monitor maternal antibodies in ewe lambs, and (d) compare serological results in milk and serum samples...
April 28, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28449081/the-coxiella-burnetii-type-ivb-secretion-system-t4bss-component-dota-is-released-secreted-during-infection-of-host-cells-and-during-in-vitro-growth-in-a-t4bss-dependent-manner
#17
Brandon E Luedtke, Saugata Mahapatra, Erika I Lutter, Edward I Shaw
Coxiella burnetii is a Gram-negative intracellular pathogen and is the causative agent of the zoonotic disease Q fever. To cause disease, C. burnetii requires a functional type IVB secretion system (T4BSS) to transfer effector proteins required for the establishment and maintenance of a membrane-bound parasitophorous vacuole (PV) and further modulation of host cell process. However, it is not clear how the T4BSS interacts with the PV membrane since neither a secretion pilus nor an extracellular pore forming apparatus has not been described...
June 1, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28441826/-a-childhood-onset-rapid-onset-dystonia-parkinsonism-family-with-atp1a3-gene-mutation-and-literatures-review
#18
C L Zhang, F Yin, F He, N Gai, Z Q Shi, J Peng
Objective: To explore clinical characteristics, treatment, and prognosis of a family with childhood-onset rapid-onset dystonia parkinsonism (RDP) caused by ATP1A3 gene mutation and review literatures. Method: The clinical data of a RDP child, his brother and mother had been analyzed retrospectively. This family was admitted to Xiangya Hospital in January 2016. DNA samples were analyzed by the next-generation sequencing and confirmed by Sanger sequencing. Related literature from PubMed, Online Mendelian Inheritance in Man (OMIM), CNKI and Wanfang databases to date (up to October 2016) with"Rapid-onset dystonia-parkinsonism"RDP"DYT12" as key words was reviewed...
April 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28441824/-clinical-and-neuroimaging-features-of-acute-encephalopathy-after-status-epilepticus-in-dravet-syndrome
#19
X J Tian, Y H Zhang, A J Liu, X L Yang, Q Zeng, Z X Yang, J T Ye, X Y Liu, Y W Jiang, X R Wu
Objective: To investigate the clinical and neuroimaging characteristics of acute encephalopathy (AE) after status epilepticus (SE) of patients with Dravet syndrome (DS). Method: The clinical data of DS patients who had AE (coma ≥24 h) after SE were retrospectively collected from February 2005 to August 2016 in Peking University First Hospital and SCN1A gene tests were performed.The clinical and neuroimaging features were summarized. Result: Twenty-two patients (9 males and 13 females) with AE were collected among 412 DS patients during follow-up...
April 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28438980/host-and-bacterial-factors-control-susceptibility-of-drosophila-melanogaster-to-coxiella-burnetii-infection
#20
Reginaldo G Bastos, Zachary P Howard, Aoi Hiroyasu, Alan G Goodman
Coxiella burnetii is the causative agent of Q fever, a zoonotic disease that threatens both human and animal health. Due to the paucity of experimental animal models, little is known about how host factors interface with bacterial components and affect pathogenesis. Here we used Drosophila melanogaster, in conjunction with the BSL2 Nine Mile phase II (NMII) clone 4 strain of C. burnetii, as a model to investigate host and bacterial components implicated in infection. We demonstrated that adult Drosophila are susceptible to C...
April 24, 2017: Infection and Immunity
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