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https://www.readbyqxmd.com/read/28434420/environmental-sampling-coupled-with-real-time-pcr-and-genotyping-to-investigate-the-source-of-a-q-fever-outbreak-in-a-work-setting
#1
A Hurtado, E Alonso, I Aspiritxaga, I López Etxaniz, B Ocabo, J F Barandika, J I Fernández-Ortiz DE Murúa, F Urbaneja, R Álvarez-Alonso, I Jado, A L García-Pérez
A Q fever outbreak was declared in February 2016 in a company that manufactures hoists and chains and therefore with no apparent occupational-associated risk. Coxiella burnetii infection was diagnosed by serology in eight of the 29 workers of the company; seven of them had fever or flu-like signs and five had pneumonia, one requiring hospitalisation. A further case of C. burnetii pneumonia was diagnosed in a local resident. Real-time PCR (RTi-PCR) showed a widespread distribution of C. burnetii DNA in dust samples collected from the plant facilities, thus confirming the exposure of workers to the infection inside the factory...
April 24, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28420442/updated-systematic-review-associations-between-proximity-to-animal-feeding-operations-and-health-of-individuals-in-nearby-communities
#2
REVIEW
Annette M O'Connor, Brent W Auvermann, Rungano S Dzikamunhenga, Julie M Glanville, Julian P T Higgins, Shelley P Kirychuk, Jan M Sargeant, Sarah C Totton, Hannah Wood, Susanna G Von Essen
OBJECTIVE: The objective of this review was to update a systematic review of associations between living near an animal feeding operation (AFO) and human health. METHODS: The MEDLINE® and MEDLINE® In-Process, Centre for Agricultural Biosciences Abstracts, and Science Citation Index databases were searched. Reference lists of included articles were hand-searched. Eligible studies reported exposure to an AFO and an individual-level human health outcome. Two reviewers performed study selection and data extraction...
April 18, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28418317/no-such-thing-as-chronic-q-fever
#3
Matthieu Million, Didier Raoult
Modern diagnostic methods enable clinicians to look beyond a diagnosis of chronic Q fever and discern whether patients instead have persistent focalized Coxiella burnetii infection(s). Use of these methods and development of criteria to define and treat such infections, especially cardiovascular infections, will improve the prognosis for patients previously thought to have chronic Q fever.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28407772/the-end-of-a-dogma-the-safety-of-doxycycline-use-in-young-children-for-malaria-treatment
#4
REVIEW
Tiphaine Gaillard, Sébastien Briolant, Marylin Madamet, Bruno Pradines
Anti-malarial drug resistance to chloroquine and sulfadoxine-pyrimethamine has spread from Southeast Asia to Africa. Furthermore, the recent emergence of resistance to artemisinin-based combination therapy (ACT) in Southeast Asia highlights the need to identify new anti-malarial drugs. Doxycycline is recommended for malaria chemoprophylaxis for travel in endemic areas, or in combination with the use of quinine for malaria treatment when ACT is unavailable or when the treatment of severe malaria with artesunate fails...
April 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28403767/tick-borne-infectious-diseases-in-australia
#5
REVIEW
Stephen R Graves, John Stenos
Tick bites in Australia can lead to a variety of illnesses in patients. These include infection, allergies, paralysis, autoimmune disease, post-infection fatigue and Australian multisystem disorder. Rickettsial (Rickettsia spp.) infections (Queensland tick typhus, Flinders Island spotted fever and Australian spotted fever) and Q fever (Coxiella burnetii) are the only systemic bacterial infections that are known to be transmitted by tick bites in Australia. Three species of local ticks transmit bacterial infection following a tick bite: the paralysis tick (Ixodes holocyclus) is endemic on the east coast of Australia and causes Queensland tick typhus due to R...
April 17, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28395434/-efficacy-and-safety-of-linezolid-among-patients-with-methicillin-resistant-staphylococcus-aureus-bacteremia
#6
S L Chen, C Y Zhu, H Zhou, Q Yang, Y H Shen, J Y Zhou
Objective: To study the efficacy and safety of linezolid for the treatment of patients with bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA). Methods: Totally 52 cases of MRSA bacteremia patients, from January 2010 to April 2014 in the First Affiliated Hospital, School of Medicine, Zhejiang University, were retrospectively analyzed. They were classified into two groups based on linezolid therapeutic regimen: primary treatment with linezolid (19 cases) and alternated to linezolid (33 cases)...
April 11, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28394892/acute-q-fever-in-febrile-patients-in-northwestern-of-iran
#7
Saber Esmaeili, Farhad Golzar, Erfan Ayubi, Behrooz Naghili, Ehsan Mostafavi
BACKGROUND: Q fever is an endemic disease in different parts of Iran. This study aimed to investigate the prevalence of acute Q fever disease among at-risk individuals in northwestern Iran. METHODOLOGY: An etiological study was carried out in 2013 in Tabriz County. A total of 116 individuals who were in contact with livestock and had a nonspecific febrile illness were enrolled in the study. IgG phase II antibodies against Coxiella burnetii were detected using ELISA...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28394889/seroprevalence-of-q-fever-among-human-and-animal-in-iran-a-systematic-review-and-meta-analysis
#8
Ashraf Mohabbati Mobarez, Fahimeh Bagheri Amiri, Saber Esmaeili
BACKGROUND: Q fever is a main zoonotic disease around the world. The aim of this meta-analysis was to estimate the overall seroprevalence of Coxiella burnetii among human and animal population in Iran. METHODS: Major national and international databases were searched from 2005 up to August 2016. We extracted the prevalence of Q fever antibodies (IgG) as the main primary outcome. We reported the prevalence of the seropositivity as point and 95% confidence intervals...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28387835/coxiella-burnetii-isolates-originating-from-infected-cattle-induce-a-more-pronounced-pro-inflammatory-cytokine-response-compared-to-isolates-from-infected-goats-and-sheep
#9
Anne Ammerdorffer, Runa Kuley, Annemieke Dinkla, Leo A B Joosten, Rudolf Toman, Hendrik-Jan Roest, Tom Sprong, Johanna M Rebel
Coxiella burnetii is the causative agent of Q fever. Although the prevalence of C. burnetii in cattle is much higher than in goats and sheep, infected cattle are rarely associated with human outbreaks. We investigated whether the immune response of humans differs after contact with C. burnetii isolates from different host origins or with different multi-locus variable number of tandem repeat analysis (MLVA) genotypes.Cytokine responses were measured in human peripheral blood mononuclear cells (PBMCs) stimulated with 16 C...
April 6, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28373734/prevalence-and-risk-factors-for-coxiella-burnetii-seropositivity-in-small-ruminant-veterinarians-and-veterinary-students-in-ontario-canada
#10
Shannon L Meadows, Andria Jones-Bitton, Scott A McEwen, Jocelyn Jansen, Samir N Patel, Catherine Filejski, Paula Menzies
Coxiella burnetii is a zoonotic pathogen that causes Q fever in humans. Serological and questionnaire data on C. burnetii were obtained from 32 small ruminant veterinarians and veterinary students in Ontario, Canada, in February 2012. Overall, 59% of participants were seropositive; advanced stage of career and increased age were associated with seropositivity.
April 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28364833/peripartum-dynamics-of-coxiella-burnetii-infections-in-intensively-managed-dairy-goats-associated-with-a-q-fever-outbreak-in-australia
#11
Michael Muleme, John Stenos, Gemma Vincent, Colin R Wilks, Joanne M Devlin, Angus Campbell, Alexander Cameron, Mark A Stevenson, Stephen Graves, Simon M Firestone
Coxiella burnetii may cause reproduction disorders in pregnant animals but subclinical infection in other animals. Unrecognised disease may delay implementation of control interventions, resulting in transmission of infection to other livestock and to humans. Seroreactivity to C. burnetii phase-specific antigens, is routinely used to interpret the course of human Q fever. This approach could be similarly useful in identifying new and existing infections in livestock herds to help describe risk factors or production losses associated with the infections and the implementation of disease-control interventions...
April 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28362816/livestock-associated-risk-factors-for-pneumonia-in-an-area-of-intensive-animal-farming-in-the-netherlands
#12
Gudrun S Freidl, Ineke T Spruijt, Floor Borlée, Lidwien A M Smit, Arianne B van Gageldonk-Lafeber, Dick J J Heederik, Joris Yzermans, Christel E van Dijk, Catharina B M Maassen, Wim van der Hoek
Previous research conducted in 2009 found a significant positive association between pneumonia in humans and living close to goat and poultry farms. However, as this result might have been affected by a large goat-related Q fever epidemic, the aim of the current study was to re-evaluate this association, now that the Q-fever epidemic had ended. In 2014/15, 2,494 adults (aged 20-72 years) living in a livestock-dense area in the Netherlands participated in a medical examination and completed a questionnaire on respiratory health, lifestyle and other items...
2017: PloS One
https://www.readbyqxmd.com/read/28355731/-the-455th-case-swollen-leg-jaundice-and-mental-disturbance
#13
R Dong, L Weng, T Guo, T N Zhu, J L Zhao, Q J Wu, X F Zeng
A 17-year-old young man with a history of swollen leg and intermittent jaundice was presented to Peking Union Medical College Hospital with acute fever and mental disturbance. He developed deep venous thrombosis, acute myocardial infarction and plantar skin necrosis during the past four years, and was presented with an acute episode of fever, thrombocytopenia, acute kidney injury, acute myocardial infarction, mental disturbance, and obstructive jaundice. Laboratory tests showed schistocytes on peripheral blood smear...
April 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28355687/-clinical-analysis-of-pelvic-abscess-with-endometriosis
#14
Y T Liu, H H Shi, X Yu, S Wang, Q B Fan, H Y Liu
Objective: To investigate the clinical features, diagnosis and treatments of pelvic abscess with endometriosis. Methods: A retrospective analysis was performed on 129 cases of pelvic abscess in Peking Union Medical College Hospital from January 2000 to January 2016. Among them, 34 women with endometriosis were divided into the study group and the others were in the control group. The clinical characteristics, therapeutic regimens and outcomes were compared. Results: (1) General conditions: there were no statistic differences between the two groups in age, WBC, serum CA(125), intrauterine device in use, pelvic inflammatory disease history; while incidence rates of dysmenorrhea (65%, 22/34) and infertility (21%, 7/34) in the study group were higher than those in the control group (all P<0...
March 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28355352/a-novel-frameshift-mutation-of-chediak-higashi-syndrome-and-treatment-in-the-accelerated-phase
#15
X L Wu, X Q Zhao, B X Zhang, F Xuan, H M Guo, F T Ma
Chediak-Higashi syndrome (CHS) is a rare autosomal recessive immunodeficiency disease characterized by frequent infections, hypopigmentation, progressive neurologic deterioration and hemophagocytic lymphohistiocytosis (HLH), known as the accelerated phase. There is little experience in the accelerated phase of CHS treatment worldwide. Here, we present a case of a 9-month-old boy with continuous high fever, hypopigmentation of the skin, enlarged lymph nodes, hepatosplenomegaly and lung infection. He was diagnosed with CHS by gene sequencing, and had entered the accelerated phase...
March 23, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28350402/metabolomics-approach-for-multibiomarkers-determination-to-investigate-dengue-virus-infection-in-human-patients
#16
Nurul Shahfiza, Hasnah Osman, Tang Thean Hock, Abdel-Hamid Zaki Abdel-Hamid
BACKGROUND: Dengue is one of the major public health problems in the world, affecting more than fifty million cases in tropical and subtropical region every year. The metabolome, as pathophysiological end-points, provide significant understanding of the mechanism and progression of dengue pathogenesis via changes in the metabolite profile of infected patients. Recent developments in diagnostic technologies provide metabolomics for the early detection of infectious diseases. METHODS: The mid-stream urine was collected from 96 patients diagnosed with dengue fever at Penang General Hospital (PGH) and 50 healthy volunteers...
March 30, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28348863/massive-dispersal-of-coxiella-burnetii-among-cattle-across-the-united-states
#17
Sonora Olivas, Heidie Hornstra, Rachael A Priestley, Emily Kaufman, Crystal Hepp, Derek L Sonderegger, Karthik Handady, Robert F Massung, Paul Keim, Gilbert J Kersh, Talima Pearson
Q-fever is an underreported disease caused by the bacterium Coxiella burnetii, which is highly infectious and has the ability to disperse great distances. It is a completely clonal pathogen with low genetic diversity and requires whole-genome analysis to identify discriminating features among closely related isolates. C. burnetii, and in particular one genotype (ST20), is commonly found in cow's milk across the entire dairy industry of the USA. This single genotype dominance is suggestive of host-specific adaptation, rapid dispersal and persistence within cattle...
August 2016: Microbial Genomics
https://www.readbyqxmd.com/read/28347916/cimicifugamide-from-cimicifuga-rhizomes-functions-as-a-nonselective-%C3%AE-ar-agonist-for-cardiac-and-sudorific-effects
#18
ZengYong Wang, Qian Wang, Man Zhang, XueYan Hu, GuoYu Ding, Min Jiang, Gang Bai
Cimicifuga rhizomes (CR) are used in the treatment of respiratory and cardiovascular diseases in traditional Chinese medicine, but their key effective components and mechanism of action have not yet been reported. In this study, the cardiac, antipyretic and sudorific effects of CR were evaluated using the toad heart failure in vitro model and mice fever and sweating in vivo models. Moreover, the UPLC/Q-TOF-MS-integrated β2-AR luciferase reporter gene assay system was used to screen the bioactive ingredients from CR extract, and the activity of this ingredient were verified using the above-mentioned in vitro and vivo models...
March 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28333617/yellow-fever-in-a-traveller-returning-from-suriname-to-the-netherlands-march-2017
#19
Marjan Wouthuyzen-Bakker, Marjolein Knoester, Aad P van den Berg, Corine H GeurtsvanKessel, Marion Pg Koopmans, Coretta Van Leer-Buter, Bob Oude Velthuis, Suzan D Pas, Wilhelmina Lm Ruijs, Jonas Schmidt-Chanasit, Stephen Gs Vreden, Tjip S van der Werf, Chantal Bem Reusken, Wouter Fw Bierman
A Dutch traveller returning from Suriname in early March 2017, presented with fever and severe acute liver injury. Yellow fever was diagnosed by (q)RT-PCR and sequencing. During hospital stay, the patient's condition deteriorated and she developed hepatic encephalopathy requiring transfer to the intensive care. Although yellow fever has not been reported in the last four decades in Suriname, vaccination is recommended by the World Health Organization for visitors to this country.
March 16, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28329131/effectiveness-of-long-term-doxycycline-treatment-and-cognitive-behavioral-therapy-on-fatigue-severity-in-patients-with-q-fever-fatigue-syndrome-qure-study-a-randomized-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
Stephan P Keijmel, Corine E Delsing, Gijs Bleijenberg, Jos W M van der Meer, Rogier T Donders, Monique Leclercq, Linda M Kampschreur, Michel van den Berg, Tom Sprong, Marrigje H Nabuurs-Franssen, Hans Knoop, Chantal P Bleeker-Rovers
Background.: Approximately 20% of patients with acute Q fever will develop chronic fatigue, referred to as Q fever fatigue syndrome (QFS). The objective of this randomized controlled clinical trial was to assess the efficacy of either long-term treatment with doxycycline or cognitive-behavioral therapy (CBT) in reducing fatigue severity in patients with QFS. Methods.: Adult patients were included who met the QFS criteria according to the Dutch guideline: a new onset of severe fatigue lasting ≥6 months with significant disabilities, related to an acute Q fever infection, without other somatic or psychiatric comorbidity explaining the fatigue...
April 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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