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Q fever

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https://www.readbyqxmd.com/read/28938256/chronic-q-fever-infections-in-israeli-children-a-25-year-nationwide-study
#1
Nimrod Sachs, Yafit Atiya-Nasagi, Adi Beth-Din, Itzhak Levy, Shalom Ben-Shimol, Diana Tasher, Galia Grisaru-Soen, Haleema Dabaja, Imad Kassis, Shiri Spilman, Efraim Bilavsky
BACKGROUND: Q fever is a zoonosis caused by the bacterium Coxiella burnetii (C. burnetii) with a worldwide distribution. Our aim was to assess the epidemiology, clinical manifestations and treatment regimens of chronic Q fever infections in Israeli children during the past 25 years. METHODS: Cases were collected from the national Q fever reference laboratory database. Demographic, epidemiologic, and clinical data were reviewed using a structured questionnaire sent to the referring physician...
September 20, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28935742/draft-genome-sequences-of-three-coxiella-burnetii-strains-isolated-from-q-fever-patients
#2
Paul A Beare, Brendan M Jeffrey, Craig A Martens, Robert A Heinzen
In the current study, we determined the draft genome sequences of three Coxiella burnetii human disease isolates. The Coxiella burnetii Turkey (RSA315) and Dyer (RSA345) strains were isolated from acute Q fever patients, while the Ko (Q229) strain was isolated from a Q fever endocarditis patient.
September 21, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28935173/coxiella-burnetiias-a-useful-tool-to-investigate-bacteria-friendly-host-cell-compartments
#3
REVIEW
Julian Pechstein, Jan Schulze-Luehrmann, Anja Lührmann
Coxiella burnetii is an obligate intracellular and airborne pathogen which can cause the zoonotic disease Q fever. After inhalation of contaminated aerosols alveolar macrophages are taking up C. burnetii into a phagosome. This phagosome matures to a very large vacuole called the C. burnetii-containing vacuole (CCV). Host endogenous and bacterial driven processes lead to the biogenesis of this unusual compartment, which resembles partially a phagolysosome. However, there are several important differences to the classical phagolysosome, which are crucial for the ability of C...
September 14, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28933682/q-vaxcelerate-a-distributed-development-approach-for-a-new-coxiella-burnetii-vaccine
#4
Patrick M Reeves, Susan Raju Paul, Ann E Sluder, Timothy A Brauns, Mark C Poznansky
Development of vaccines that are both safe and effective remains a costly and time-consuming challenge. To accelerate the pace of development and improve the efficacy and safety of candidate vaccines for both existing and emerging infectious agents, we have employed a distributed development approach. This features the managed integration of individual expert groups having the requisite vaccine platforms, pre-clinical models, assays, skills and knowledge pertinent to a specific pathogen into a single, end-to-end development team capable of producing a new vaccine tailored to that particular agent...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28932685/pig-s-ear-streptococcus-suis-meningitis-and-its-associated-inner-ear-implications
#5
S Sena Esteves, J Carvalho de Almeida, J Abrunhosa, C Almeida E Sousa, Q Arshad
Streptococcus suis (S. suis) is a zoonotic pathogen commonly found in Asian countries. Infection with this bacterium typically clinically presents as meningitis and individuals whom handle swine are at increased risk of developing infections. We present a case of a patient with a S. suis meningitis who worked as a butcher. The 48-year-old man was admitted to our department with headaches, fevers, nausea and bilateral hearing loss. According to his medical history, the patient had sustained a cut on his finger while preparing pork meat...
2017: IDCases
https://www.readbyqxmd.com/read/28915918/a-longitudinal-study-of-serological-responses-to-coxiella-burnetii-and-shedding-at-kidding-among-intensively-managed-goats-supports-early-use-of-vaccines
#6
Michael Muleme, Angus Campbell, John Stenos, Joanne M Devlin, Gemma Vincent, Alexander Cameron, Stephen Graves, Colin R Wilks, Simon Firestone
Vaccination against Coxiella burnetii, the cause of Q fever, is reportedly the only feasible strategy of eradicating infection in ruminant herds. Preventive vaccination of seronegative goats is more effective in reducing shedding of C. burnetii than vaccinating seropositive goats. The age at which goats born on heavily-contaminated farms first seroconvert to C. burnetii has not yet been documented. In a 16-month birth cohort study, the age at which goats seroconverted against C. burnetii was investigated; 95 goats were bled every 2 weeks and tested for antibodies against C...
September 15, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28899604/clinical-and-epidemiological-use-of-nested-pcr-targeting-the-repetitive-element-is1111-associated-with-the-transposase-gene-from-coxiella-burnetii
#7
Maria Angélica M M Mares-Guia, Alexandro Guterres, Tatiana Rozental, Michelle Dos Santos Ferreira, Elba R S Lemos
Q fever is a worldwide zoonosis caused by Coxiella burnetii-a small obligate intracellular Gram-negative bacterium found in a variety of animals. It is transmitted to humans by inhalation of contaminated aerosols from urine, feces, milk, amniotic fluid, placenta, abortion products, wool, and rarely by ingestion of raw milk from infected animals. Nested PCR can improve the sensitivity and specificity of testing while offering a suitable amplicon size for sequencing. Serial dilutions were performed tenfold to test the limit of detection, and the result was 10× detection of C...
August 24, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28899307/atypical-outbreak-of-q-fever-affecting-low-risk-residents-of-a-remote-rural-town-in-new-south-wales
#8
Brett N Archer, Cathie Hallahan, Priscilla Stanley, Kathy Seward, Margaret Lesjak, Kirsty Hope, Anthony Brown
We investigated an outbreak of Q fever in a remote rural town in New South Wales, Australia. Cases identified through active and passive case finding activities, and retrospective laboratory record review were interviewed using a standard questionnaire. Two sets of case-case analyses were completed to generate hypotheses regarding clinical, epidemiological and exposure risk factors associated with infection during the outbreak. Laboratory-confirmed outbreak cases (n=14) were compared with an excluded case group (n=16) and a group of historic Q fever cases from the region (n=106)...
June 30, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28893076/seroprevalence-and-risk-factors-for-i-coxiella-burnetii-i-the-causative-agent-of-q-fever-in-the-dromedary-camel-i-camelus-dromedarius-i-population-in-algeria
#9
Mohammed H Benaissa, Samir Ansel, Abdallah Mohamed-Cherif, Karima Benfodil, Djamel Khelef, Curtis R Youngs, Rachid Kaidi, Khatima Ait-Oudhia
Query (Q) fever is a globally distributed zoonotic disease caused by Coxiella burnetii, a bacterial agent for which ruminants are the most prevalent natural reservoir. Data regarding Q fever infection in camels in Algeria are limited. Therefore, a survey to detect seroprevalence of C. burnetii antibodies was conducted among healthy camel populations in a vast area in southeastern Algeria to determine distribution of the Q fever causative organism and to identify risk factors associated with infection. Between January and March 2016, blood samples were collected from 184 camels and serum samples were subsequently analysed using a commercial Enzyme-Linked Immunosorbent Assay (ELISA) kit...
August 31, 2017: Onderstepoort Journal of Veterinary Research
https://www.readbyqxmd.com/read/28886329/a-case-of-igg4-related-retroperitoneal-fibrosis-with-multiple-involvement
#10
Y-K Zheng, N-Y Gu, J Wu, X Fang, C Zhang, Q-Y Li
To increase awareness of IgG4-related retroperitoneal fibrosis (IgG4-RRPF) and reduce clinical misdiagnosis. We report a 79-year-old man with multiple organs involvement of IgG4-RRPF, who developed right lower extremity edema, hemoptysis and fever. The abdomen computed tomography (CT) scan image showed lymph nodes enlargement. The positron emission tomography/CT scan image showed pancreatic malignancy with multiple nodal lymph node metastasis, lung fibroblast proliferation, and right lung apex bullae. The chest CT scan image showed pulmonary multiple lymph nodes with calcification in the mediastinum...
August 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28873022/seroprevalence-of-leptospirosis-brucellosis-and-q-fever-in-a-wild-red-deer-cervus-elaphus-population-kept-in-a-fenced-reserve-in-absence-of-contact-with-livestock
#11
Jose María San-Miguel Ayanz, Francisco Javier Garcia-Peña, Paula García-Lunar, Luis Miguel Ortega-Mora, María José Ruano, Gema Álvarez-García, Esther Collantes-Fernández
Wildlife health is of interest for public and animal health because wild animals have been identified as important sentinels for the surveillance for zoonotic pathogens. This work investigated Brucella spp., Coxiella burnetii, and Leptospira spp. infection seroprevalence in a free-ranging red deer population. The study was conducted in a fenced reserve with controlled hunting activity in central Spain with animals that did not have any contact with livestock. Sampling was performed at two time points before and 5 years after the implementation of new management measures, including a reduction in the red deer population in the reserve...
September 5, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28868312/a-case-of-primary-aortoduodenal-fistula-and-abdominal-aortic-aneurysm-in-a-patient-with-chronic-q-fever
#12
Arne de Niet, Ignace F J Tielliu, Paul M van Schaik, Jan J A M van den Dungen, Clark J Zeebregts
A 70-year-old man was successfully treated for an aortoduodenal fistula originating from a Q fever-related abdominal aortic aneurysm. He had no known history of contact with cattle or sheep. Although the combination of abdominal aortic aneurysm and aortoduodenal fistula is rare, one should be suspicious of Q fever infection as the causative agent, and additional medical treatment should be initiated.
February 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/28867393/reprint-of-epidemiology-of-brucellosis-q-fever-and-rift-valley-fever-at-the-human-and-livestock-interface-in-northern-c%C3%A3-te-d-ivoire
#13
Youssouf B Kanouté, Biégo G Gragnon, Christian Schindler, Bassirou Bonfoh, Esther Schelling
Northern Côte d'Ivoire is the main livestock breeding zone and has the highest livestock cross-border movements in Côte d'Ivoire. The aim of this study was to provide updated epidemiological data on three neglected zoonotic diseases, namely brucellosis, Q Fever and Rift Valley Fever (RVF). We conducted three-stage cross-sectional cluster surveys in livestock and humans between 2012 and 2014 in a random selection of 63 villages and a sample of 633 cattle, 622 small ruminants and 88 people. We administered questionnaires to capture risk factors and performed serological tests including the Rose Bengal Plate Test (RBPT), Brucella spp...
September 1, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28859349/from-expert-protocols-to-standardized-management-of-infectious-diseases
#14
Jean-Christophe Lagier, Camille Aubry, Marion Delord, Pierre Michelet, Hervé Tissot-Dupont, Matthieu Million, Philippe Brouqui, Didier Raoult, Philippe Parola
We report here 4 examples of management of infectious diseases (IDs) at the University Hospital Institute Méditerranée Infection in Marseille, France, to illustrate the value of expert protocols feeding standardized management of IDs. First, we describe our experience on Q fever and Tropheryma whipplei infection management based on in vitro data and clinical outcome. Second, we describe our management-based approach for the treatment of infective endocarditis, leading to a strong reduction of mortality rate...
August 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28858264/comparison-of-chemical-profiles-anti-inflammatory-activity-and-uplc-q-tof-ms-based-metabolomics-in-endotoxic-fever-rats-between-synthetic-borneol-and-natural-borneol
#15
Liang Zou, Yan Zhang, Wei Li, Jinming Zhang, Dan Wang, Jia Fu, Ping Wang
Natural borneol (NB, called "Bingpian") is an important traditional Chinese medicine to restore consciousness, remove heat and relieve pain, all of which are inflammation-related diseases. Recently, due to the limited source of NB, synthetic borneol (SB) is widely used as a substitute for NB in clinics. However, little is known about the effects of SB instead of NB. Herein, the aim of the present study was to compare NB and SB on chemical profiles by gas chromatography-mass spectrometer (GC-MS) analysis, anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW 264...
August 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28854806/coxiella-burnetii-immunogenic-proteins-as-a-basis-for-new-q-fever-diagnostic-and-vaccine-development
#16
C Gerlach, Ľ Škultéty, K Henning, H Neubauer, K Mertens
Coxiella burnetii is the etiological agent of the zoonosis Q fever, which can cause an acute or a chronic, life-threatening disease in humans. It presents a highly stable cell form, which persists in the environment and is transmitted via contaminated aerosols. Ruminants are considered as the main reservoir for human infections but are usually asymptomatic. Subclinical infection in these animals and the occurrence of serologically negative shedders hamper the identification of infected animals with the currently used diagnostic techniques...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28854805/two-mice-models-for-transferability-of-zoonotic-bacteria-via-tick-vector
#17
B Sallay, T Vaculová, M Derdáková, V Rusňáková Tarageľová, E Špitalská, Ľ Škultéty
Spotted fever and typhus-related diseases caused by rickettsiae, Lyme borreliosis induced by spirochetes from Borrelia burgdorferii sensu lato complex, and Q fever evoked by Coxiella burnetii, are important zoonoses occurring worldwide. In order to study the pathogenesis of these infections, the efficacy of vaccines from the perspective of protection against the pathogens, pathogen - pathogen interactions during co-infections or pathogen-vector-host interrelationship, a suitable animal model should be established...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28854804/seroprevalence-of-coxiella-burnetii-among-domestic-ruminants-and-horses-in-poland
#18
M Szymańska-Czerwińska, A Jodełko, M Pluta, S Kowalik, K Niemczuk
Coxiella burnetii is the causative agent of Q fever. The cases of the disease are recorded in various species, including domestic animals. The aim of this investigation was to estimate the seroprevalence of C. burnetii in ruminants including cattle, sheep, goats, and horses. Totally, 2082 serum samples from 936 goats, 933 cattle, 89 sheep, and 124 horses, including various horse breeds, were tested by ELISA or complement fixation test. The examination revealed that Polish horses are seronegative while in the populations of cattle and small ruminants, seropositive animals are presented...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28854803/protein-composition-of-the-phase-i-coxiella-burnetii-soluble-antigen-prepared-by-extraction-with-trichloroacetic-acid
#19
G Flores-Ramírez, M Kmeťová, M Danchenko, E Špitalská, V Havlíček, Ľ Škultéty
Q fever is a highly infectious, widespread airborne zoonosis caused by Coxiella burnetii bacterium. Humans usually acquire the disease by inhalation of contaminated aerosol produced by infected livestock. Vaccination is the most practical way for prevention and control of the disease in the exposed population. In this work, we reviewed the most important Q-fever outbreaks in Slovakia as well as the progress in vaccine development. One of them represents a soluble antigen complex produced by extraction with trichloroacetic acid from a highly purified C...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28854800/workshop-on-q-fever
#20
Ľ Škultéty
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2017: Acta Virologica
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