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https://www.readbyqxmd.com/read/29168790/coxiella-burnetii-lipopolysaccharide-what-do-we-know
#1
REVIEW
Prasad Abnave, Xavier Muracciole, Eric Ghigo
A small gram-negative bacterium, Coxiella burnetii (C. burnetii), is responsible for a zoonosis called Q fever. C. burnetii is an intracellular bacterium that can survive inside microbicidal cells like monocytes and macrophages by hijacking several functions of the immune system. Among several virulence factors, the lipopolysaccharide (LPS) of C. burnetii is one of the major factors involved in this immune hijacking because of its atypical composition and structure. Thus, the aim of this mini-review is to summarize the repressive effects of C...
November 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29166732/-application-of-pegylated-recombinant-human-granulocyte-colony-stimulating-factor-to-prevent-chemotherapy-induced-neutropenia-in-patients-with-lymphoma-a-prospective-multicenter-open-label-clinical-trial
#2
H Q Huang, B Bai, Y H Gao, D H Zou, S H Zou, H Tan, Y P Song, Z Y Li, J Jin, W Li, H Su, Y P Gong, M Z Zhong, Y R Shuang, J Zhu, J Q Zhang, Z Cai, Q L Teng, W J Sun, Y Yang, Z J Xia, H L Chen, L M Hua, Y Y Bao, N Wu
Objective: To evaluate the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in prophylaxis neutropenia after chemotherapy in patients with lymphoma. Methods: This was a multicenter, single arm, open, phase Ⅳ clinical trial. Included 410 patients with lymphoma received multiple cycles of chemotherapy and PEG-rhG-CSF was administrated as prophylactic. The primary endpoint was the incidence of Ⅲ/Ⅳ grade neutropenia and febrile neutropenia (FN) after each chemotherapy cycle...
October 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29157226/remarkable-spatial-variation-in-the-seroprevalence-of-coxiella-burnetii-after-a-large-q-fever-epidemic
#3
Roan Pijnacker, Johan Reimerink, Lidwien A M Smit, Arianne B van Gageldonk-Lafeber, Jan-Paul Zock, Floor Borlée, Joris Yzermans, Dick J J Heederik, Catharina B M Maassen, Wim van der Hoek
BACKGROUND: Prior to the 2007-2010 Q fever epidemic in the Netherlands, the seroprevalence of antibodies against Coxiella burnetii in the general population was 1.5%, which is low compared to other countries. We aimed to determine the seroprevalence after the Q fever epidemic among people living in the affected area, compare the seroprevalence with the incidence of Q fever notifications during the 2007-2010 Q fever epidemic, and to identify farm exposures associated with having antibodies against C...
November 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29142131/single-dose-trivalent-vesiculovax-vaccine-protects-macaques-from-lethal-ebolavirus-and-marburgvirus-challenge
#4
Demetrius Matassov, Chad E Mire, Theresa Latham, Joan B Geisbert, Rong Xu, Ayuko Ota-Setlik, Krystle N Agans, Dean J Kobs, Morgan Q S Wendling, Amanda Burnaugh, Thomas L Rudge, Carol L Sabourin, Michael A Egan, David K Clarke, Thomas W Geisbert, John H Eldridge
Previous studies demonstrated that a single intramuscular (IM) dose of an attenuated vesicular stomatitis virus vector (Vesiculovax™, rVSV-N4CT1) expressing the glycoprotein (GP) from the Mayinga strain of Zaire ebolavirus (EBOV) protected nonhuman primates (NHP) from lethal challenge with EBOV Kikwit and Makona strains. Here we studied the immunogenicity of an expanded range of attenuated rVSV vectors expressing filovirus GP in mice. Based on data from those studies an optimal attenuated tri-valent rVSV vector formulation was identified which included rVSV vectors expressing EBOV, Sudan ebolavirus (SUDV) or Angola strain of Marburg marburgvirus (MARV) GPs...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29141767/acute-q-fever-case-detection-among-acute-febrile-illness-patients-thailand-2002-2005
#5
Ashley L Greiner, Saithip Bhengsri, Matthieu Million, Sophie Edouard, Somsak Thamthitiwat, Kevin Clarke, Gilbert J Kersh, Christopher J Gregory, Didier Raoult, Philippe Parola
Acute Q fever cases were identified from a hospital-based acute febrile illness study conducted in six community hospitals in rural north and northeast Thailand from 2002 to 2005. Of 1,784 participants that underwent Coxiella burnetii testing, nine (0.5%) participants were identified in this case-series as acute Q fever cases. Eight case-patients were located in one province. Four case-patients were hospitalized. Median age was 13 years (range: 7-69); five were male. The proportion of children with acute Q fever infection was similar to adults (P = 0...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29141338/-spatial-and-temporal-clustering-characteristics-of-typhoid-and-paratyphoid-fever-and-its-change-pattern-in-3-provinces-in-southwestern-china-2001-2012
#6
L X Wang, B Yang, M Y Yan, Y Q Tang, Z C Liu, R Q Wang, S Li, L Ma, B Kan
Objective: To analyze the spatial and temporal clustering characteristics of typhoid and paratyphoid fever and its change pattern in Yunnan, Guizhou and Guangxi provinces in southwestern China in recent years. Methods: The incidence data of typhoid and paratyphoid fever cases at county level in 3 provinces during 2001-2012 were collected from China Information System for Diseases Control and Prevention and analyzed by the methods of descriptive epidemiology and geographic informatics. And the map showing the spatial and temporal clustering characters of typhoid and paratyphoid fever cases in three provinces was drawn...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29141337/-epidemiology-of-imported-infectious-diseases-in-china-2013-2016
#7
Y L Wang, X Wang, R Q Ren, L Zhou, W W Tu, D X Ni, Q Li, Z J Feng, Y P Zhang
Objective: To describe the epidemic of imported infectious diseases in China between 2013 and 2016, including the kinds of infectious diseases, affected provinces, source countries and the epidemiological characteristics, and provide scientific information for the prevention and control of imported infectious diseases. Methods: Data of cases of imported infectious diseases in China from 2013 to 2016 were collected from national information reporting system of infectious diseases, Microsoft Excel 2010 and SPSS 18...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29141329/-association-between-illness-and-mental-status-in-pregnant-women-and-birth-defects
#8
D D Zhao, Y X Dai, L Q Guo, R Liu, H L Wang, B B Mi, S N Dang, H Yan
Objective: To understand the prevalence of birth defects, related diseases and mental status of women during pregnancy in Shaanxi province and to analyse the major risk factors on birth defects and congenital heart disease. Possible association between maternal diseases or mental status and the risk of birth defects, was also explored. Methods: A cross-sectional design was used in this study and stratified multistage random sampling method was used. The whole survey was from Jury 2013 to November 2013. Logistic regression method was used to analyze the association between maternal diseases, mental status during pregnancy and birth defects...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29141313/-tocilizumab-for-refractory-systemic-juvenile-idiopathic-arthritis
#9
J M Lai, F Q Wu, Z X Zhou, M Kang, X L Huang, G X Su, S N Li, J Zhu, X N Wang
Objective: To evaluate the efficacy and side effects of tocilizumab for the treatment of systemic juvenile idiopathic arthritis. Method: In this prospective self case-control study, the children diagnosed with refractory systemic juvenile idiopathic arthritis admitted to Department of Rheumatism and Immunology of Children's Hospital Affiliated to Capital Institute of Pediatrics from December 2013 to June 2016 were enrolled and information before and after treatment of tocilizumab was analyzed. The tocilizumab was introvenously guttae in a dose of 8-12 mg/kg every 2 weeks...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29141023/domestic-sheep-show-average-coxiella-burnetii-seropositivity-generations-after-a-sheep-associated-human-q-fever-outbreak-and-lack-detectable-shedding-by-placental-vaginal-and-fecal-routes
#10
Ryan D Oliveira, Michelle R Mousel, Kristy L Pabilonia, Margaret A Highland, J Bret Taylor, Donald P Knowles, Stephen N White
Coxiella burnetii is a globally distributed zoonotic bacterial pathogen that causes abortions in ruminant livestock. In humans, an influenza-like illness results with the potential for hospitalization, chronic infection, abortion, and fatal endocarditis. Ruminant livestock, particularly small ruminants, are hypothesized to be the primary transmission source to humans. A recent Netherlands outbreak from 2007-2010 traced to dairy goats resulted in over 4,100 human cases with estimated costs of more than 300 million euros...
2017: PloS One
https://www.readbyqxmd.com/read/29140515/surveillance-for-q-fever-endocarditis-in-the-united-states-1999-2015
#11
Anne Straily, F Scott Dahlgren, Amy Peterson, Christopher D Paddock
Background: Q fever is a worldwide zoonosis caused by Coxiella burnetii. In some persons, particularly those with cardiac valve disease, infection with C. burnetii can cause a life-threatening infective endocarditis. There are few descriptive analyses of Q fever endocarditis in the United States. Methods: Q fever case report forms submitted during 1999-2015 were reviewed to identify reports describing endocarditis. Cases were categorized as confirmed or probable using criteria defined by the Council for State and Territorial Epidemiologists (CSTE)...
November 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29136691/-tumors-of-lymphoid-and-hematopoietic-tissue-of-spleen-a-clinicopathologic-analysis-of-53-cases
#12
D B Chen, D H Shen, H Zhang, Y Wang, Q J Song, S M Yang, X Z Fang
Objective: To study the clinicopathologic features, diagnosis and differential diagnosis of the tumors of lymphoidand hematopoietic tissue of the spleen(TLTS). Methods: Fifty-three cases of TLTS were selected from the pathologic files from Peking University People's Hospital from April 2002 to April 2017. According to WHO classification of tumors of hematopoietic and lymphoid tissues (2008) and its updated classification (2016), the cases were studied by microscopy, immunohistochemistry and in situ hybridization, combined with the bone marrow biopsy and clinical examination...
November 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29132996/q-vax-q-fever-vaccine-failures-victoria-australia-1994-2013
#13
Katherine A Bond, Lucinda J Franklin, Brett Sutton, Simon M Firestone
Q-Vax®, a whole cell formalin inactivated vaccine, is currently the only licensed Q fever vaccine for humans world-wide. Efficacy is high, although vaccine failures have been described for those vaccinated within the incubation of a naturally acquired infection. In Australia, it is widely used to prevent occupational acquisition of Q fever and is the mainstay for outbreak control. A retrospective review of all notified cases of acute Q fever to the Victorian department of health, 1993-2013, revealed 34 of 659 cases were previously vaccinated and 10 cases were positive on pre-vaccination screening, precluding vaccination...
November 10, 2017: Vaccine
https://www.readbyqxmd.com/read/29130123/informal-value-chain-actors-knowledge-and-perceptions-about-zoonotic-diseases-and-biosecurity-in-kenya-and-the-importance-for-food-safety-and-public-health
#14
Simon Nyokabi, Regina Birner, Bernard Bett, Linda Isuyi, Delia Grace, Denise Güttler, Johanna Lindahl
Zoonotic diseases, transmitted from animals to humans, are a public health challenge in developing countries. Livestock value chain actors have an important role to play as the first line of defence in safeguarding public health. However, although the livelihood and economic impacts of zoonoses are widely known, adoption of biosecurity measures aimed at preventing zoonoses is low, particularly among actors in informal livestock value chains in low and middle-income countries. The main objective of this study was to investigate knowledge of zoonoses and adoption of biosecurity measures by livestock and milk value chain actors in Bura, Tana River County, in Kenya, where cattle, camels, sheep and goats are the main livestock kept...
November 13, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29120485/measuring-ph-of-the-coxiella-burnetii-parasitophorous-vacuole
#15
Dhritiman Samanta, Stacey D Gilk
Coxiella burnetii is the causative agent of human Q fever, a zoonotic disease that can cause a debilitating, flu-like illness in acute cases, or a life-threatening endocarditis in chronic patients. An obligate intracellular bacterial pathogen, Coxiella survives and multiplies in a large lysosome-like vacuole known as the Coxiella parasitophorous vacuole (CPV). A unique characteristic of the CPV is the acidic environment (pH ∼5.0), which is required to activate Coxiella metabolism and the Coxiella type 4 secretion system (T4SS), a major virulence factor required for intracellular survival...
November 9, 2017: Current Protocols in Microbiology
https://www.readbyqxmd.com/read/29069320/breast-implant-q-fever-as-a-source-of-in-hospital-transmission
#16
Ayal Hassidim, Hila Elinav, Ayelet Michael-Gayego, Shmuel Benenson, Shlomi Yaalomy, Karen Meir, Uriel Elchalal, Tomer Tzur
Herein, we describe the first case of mammary implant infection caused by Coxiella b urnetii , resulting in delayed diagnosis and treatment and an in-hospital cross transmission of Q-fever to medical personnel.
October 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29060965/-clinical-retrospective-control-study-of-single-port-laparoendoscopic-and-multi-port-laparoscopic-ovarian-cystectomy
#17
X Liu, M K Wen, H Y Liu, D W Sun, J H Lang, Q B Fan, H H Shi
Objective: To investigate clinical outcomes of laparoendoscopic single-site ovarian cystectomy compared with traditional multi-port laparoscopic ovarian cystectomy. Methods: Data of 81 patients with ovarian cystectomy from January 2016 to May 2017, the single-site group (n=40) and the multi-port group (n=41) in Peking Union Medical College Hospital were retrospectively collected. The outcomes of single-site and multi-port groups were analyzed and compared, including: postoperative fever, operation time, blood loss, hemoglobin change, surgical complications, postoperative pain score, postoperative analgesic requirements, body image scale and cosmetic score, length of hospital stay, postoperative total cost...
October 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29057336/evaluation-of-the-stability-of-lyophilized-loop-mediated-isothermal-amplification-reagents-for-the-detection-of-coxiella-burnetii
#18
Hua-Wei Chen, Wei-Mei Ching
Coxiella burnetii, the causative pathogen for Q fever, is an obligate intracellular bacterium and designated as a biosafety level 3 agent. Detection and quantification of the bacteria with conventional culturing methods is time-consuming and poses significant health risks. Polymerase chain reaction (PCR)-based assays have been developed for detecting C. burnetii and could provide rapid diagnosis. However, they require specialized equipment, including a cold chain for PCR reagents that maintains their stability during storage and transport...
October 2017: Heliyon
https://www.readbyqxmd.com/read/29056687/the-epidemiology-of-q-fever-in-england-and-wales-2000-2015
#19
Kate D Halsby, Hilary Kirkbride, Amanda L Walsh, Ebere Okereke, Timothy Brooks, Matthew Donati, Dilys Morgan
Between 2000 and 2015, 904 cases of acute Q fever were reported in England and Wales. The case dataset had a male to female ratio of 2.5:1, and a median age of 45 years. Two outbreaks were recognised during this time period, and the incidence of sporadic cases was highest across the southwest of England, and Wales. There are limitations in the surveillance system for Q fever, including possible geographical differences in reporting and limited epidemiological data collection. The surveillance system needs to be strengthened in order to improve the quality and completeness of the epidemiological dataset...
May 19, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29050175/-effects-of-retroperitoneal-laparoscopic-ureterolithotomy-and-flexible-ureteroscopic-holmium-laser-lithotripsy-for-complex-upper-ureteral-calculi
#20
L J Zhang, B Wu, Z L Zha, H Zhao, W Yang, X H Chen, B Jiang, Q Huang, W J Li, J Yuan
Objective: To explore the clinical effects of retroperitoneal laparoscopic ureterolithotomy (RPLU) and flexible-ureteroscopic holmium laser lithotripsy (f-UHLL) for complicated upper ureteral calculi. Methods: A total of 45 cases of complicated upper ureteral calculi between March 2014 and January 2016 in Department of Urology, Affiliated Jiangyin Hospital of Southeast University Medical College were retrospectively analyzed, there were 32 males and 13 females, ranging from 27 to 45 years with an average age of (34...
October 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
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