keyword
https://read.qxmd.com/read/37509519/post-traumatic-stress-response-and-appendicitis-in-children-clinical-usefulness-of-selected-biomarkers
#21
JOURNAL ARTICLE
Jarosław Sobczak, Monika Burzyńska, Anna Sikora, Anna Wysocka, Jakub Karawani, Janusz P Sikora
Acute appendicitis is an inflammatory process which is one of the most frequent global causes of surgical interventions in children. The goal of the study was to determine whether acute phase proteins, that is, C-reactive protein (CRP), procalcitonin (PCT) and neutrophil gelatinase-associated lipocalin (NGAL), interleukin 6 (IL-6), transforming growth factor-beta1 (TGF-β1) and cortisol (HC) play a role in the pathomechanism of post-trauma stress response of the organism and to establish the impact of the applied surgical procedure and/or of inflammation on their concentrations...
July 2, 2023: Biomedicines
https://read.qxmd.com/read/37398193/dna-guided-transcription-factor-cooperativity-shapes-face-and-limb-mesenchyme
#22
Seungsoo Kim, Ekaterina Morgunova, Sahin Naqvi, Maram Bader, Mervenaz Koska, Alexander Popov, Christy Luong, Angela Pogson, Peter Claes, Jussi Taipale, Joanna Wysocka
Transcription factors (TFs) can define distinct cellular identities despite nearly identical DNA-binding specificities. One mechanism for achieving regulatory specificity is DNA-guided TF cooperativity. Although in vitro studies suggest it may be common, examples of such cooperativity remain scarce in cellular contexts. Here, we demonstrate how 'Coordinator', a long DNA motif comprised of common motifs bound by many basic helix-loop-helix (bHLH) and homeodomain (HD) TFs, uniquely defines regulatory regions of embryonic face and limb mesenchyme...
May 29, 2023: bioRxiv
https://read.qxmd.com/read/37394917/a-single-amino-acid-substitution-in-mdlazy1a-dominantly-impairs-shoot-gravitropism-in-malus
#23
JOURNAL ARTICLE
Laura Dougherty, Ewa Borejsza-Wysocka, Alexandre Miaule, Ping Wang, Desen Zheng, Michael Jansen, Susan Brown, Miguel Piñeros, Christopher Dardick, Kenong Xu
Plant architecture is one of the most important factors that determines crop yield potential and productivity. In apple (Malus domestica), genetic improvement of tree architecture has been challenging due to a long juvenile phase and growth as complex trees composed of a distinct scion and a rootstock. To better understand the genetic control of apple tree architecture, the dominant weeping growth phenotype was investigated. We report the identification of MdLAZY1A (MD13G1122400) as the genetic determinant underpinning the Weeping (W) locus that largely controls weeping growth in Malus...
July 3, 2023: Plant Physiology
https://read.qxmd.com/read/37189058/a-systematic-review-of-biologically-informed-deep-learning-models-for-cancer-fundamental-trends-for-encoding-and-interpreting-oncology-data
#24
JOURNAL ARTICLE
Magdalena Wysocka, Oskar Wysocki, Marie Zufferey, Dónal Landers, André Freitas
BACKGROUND: There is an increasing interest in the use of Deep Learning (DL) based methods as a supporting analytical framework in oncology. However, most direct applications of DL will deliver models with limited transparency and explainability, which constrain their deployment in biomedical settings. METHODS: This systematic review discusses DL models used to support inference in cancer biology with a particular emphasis on multi-omics analysis. It focuses on how existing models address the need for better dialogue with prior knowledge, biological plausibility and interpretability, fundamental properties in the biomedical domain...
May 15, 2023: BMC Bioinformatics
https://read.qxmd.com/read/37179464/alternative-three-point-lead-configuration-for-successful-external-dc-cardioversion-in-seven-feet-tall-former-basketball-player
#25
JOURNAL ARTICLE
Katarzyna Wysokińska, Katarzyna Wojewoda, Krzysztof Poleszak, Marcin Janowski, Anna Wysocka, Andrzej Wysokinski, Andrzej Glowniak
No abstract text is available yet for this article.
May 14, 2023: Kardiologia Polska
https://read.qxmd.com/read/37164018/co-transcriptional-genome-surveillance-by-hush-is-coupled-to-termination-machinery
#26
JOURNAL ARTICLE
Andrew L Spencley, Shiran Bar, Tomek Swigut, Ryan A Flynn, Cameron H Lee, Liang-Fu Chen, Michael C Bassik, Joanna Wysocka
The HUSH complex recognizes and silences foreign DNA such as viruses, transposons, and transgenes without prior exposure to its targets. Here, we show that endogenous targets of the HUSH complex fall into two distinct classes based on the presence or absence of H3K9me3. These classes are further distinguished by their transposon content and differential response to the loss of HUSH. A de novo genomic rearrangement at the Sox2 locus induces a switch from H3K9me3-independent to H3K9me3-associated HUSH targeting, resulting in silencing...
April 28, 2023: Molecular Cell
https://read.qxmd.com/read/37110142/the-effect-of-75-grams-of-glucose-during-ogtt-on-plasma-markers-of-lipid-and-lipoprotein-peroxidation-oxidized-ldl-and-thiobarbituric-acid-reactive-substances-in-people-with-increased-body-mass
#27
JOURNAL ARTICLE
Lena Bielawska, Ewa Wysocka, Aleksandra Baszczuk, Anna Dżumak, Aleksandra Ludziejewska, Maciej Cymerys, Alicja Płóciniczak
Obesity, currently defined as a disease, is associated with a number of metabolic disorders, and oxidative stress is discussed as the link between them. The aim of this study was to analyze the plasma markers reflecting oxidative modification of lipids and lipoproteins, oxidized LDL (oxLDL) and thiobarbituric acid reactive substances (TBARS), under the influence of the 75 g of oral glucose during oral glucose tolerance test (OGTT), in patients with increased body mass. One hundred twenty individuals of both genders (46 women and 74 men) aged 26 to 75 years with increased body mass (BMI > 25 kg/m2 ) were recruited for the study...
March 27, 2023: Metabolites
https://read.qxmd.com/read/37105509/meta-analysis-informed-machine-learning-supporting-cytokine-storm-detection-during-car-t-cell-therapy
#28
JOURNAL ARTICLE
Alex Bogatu, Magdalena Wysocka, Oskar Wysocki, Holly Butterworth, Manon Pillai, Jennifer Allison, Dónal Landers, Elaine Kilgour, Fiona Thistlethwaite, André Freitas
Cytokine release syndrome (CRS), also known as cytokine storm, is one of the most consequential adverse effects of chimeric antigen receptor therapies that have shown otherwise promising results in cancer treatment. When emerging, CRS could be identified by the analysis of specific cytokine and chemokine profiles that tend to exhibit similarities across patients. In this paper, we exploit these similarities using machine learning algorithms and set out to pioneer a meta-review informed method for the identification of CRS based on specific cytokine peak concentrations and evidence from previous clinical studies...
April 25, 2023: Journal of Biomedical Informatics
https://read.qxmd.com/read/37067900/snrk1-kinase-mediated-phosphorylation-of-transcription-factor-bzip39-regulates-sorbitol-metabolism-in-apple
#29
JOURNAL ARTICLE
Dong Meng, Hongyan Cao, Qing Yang, Mengxia Zhang, Ewa Borejsza-Wysocka, Huicong Wang, Abhaya M Dandekar, Zhangjun Fei, Lailiang Cheng
Sorbitol is a major photosynthate produced in leaves and transported through the phloem of apple (Malus domestica) and other tree fruits in Rosaceae. Sorbitol stimulates its own metabolism, but the underlying molecular mechanism remains unknown. Here we show that sucrose non-fermenting 1 (SNF1)-related protein kinase 1 (SnRK1) is involved in regulating the sorbitol-responsive expression of both SORBITOL DEHYDROGENASE 1 (SDH1) and ALDOSE-6-PHOSPHATE REDUCTASE (A6PR), encoding two key enzymes in sorbitol metabolism...
April 17, 2023: Plant Physiology
https://read.qxmd.com/read/37059813/a%C3%A2-new-extremophile-ostracod-crustacean-from-the-movile-cave-sulfidic-chemoautotrophic-ecosystem-in-romania
#30
JOURNAL ARTICLE
Sanda Iepure, Anna Wysocka, Serban M Sarbu, Michalina Kijowska, Tadeusz Namiotko
Sulfidic cave ecosystems are remarkable evolutionary hotspots that have witnessed adaptive radiation of their fauna represented by extremophile species having particular traits. Ostracods, a very old group of crustaceans, exhibit specific morphological and ecophysiological features that enable them to thrive in groundwater sulfidic environments. Herein, we report a peculiar new ostracod species Pseudocandona movilaensis sp. nov. thriving in the chemoautotrophic sulfidic groundwater ecosystem of Movile Cave (Romania)...
April 14, 2023: Scientific Reports
https://read.qxmd.com/read/37046920/time-perspective-as-a-mediator-of-depressive-symptoms-in-patients-with-polycystic-ovary-syndrome
#31
JOURNAL ARTICLE
Agnieszka Adamczak, Włodzimierz Płotek, Aleksandra Głowińska, Małgorzata Sobol, Ewa Wysocka, Grzegorz Polak, Izabela Dymanowska-Dyjak, Julia Spaczyńska, Łukasz Adamczak, Beata Banaszewska
BACKGROUND: Polycystic ovary syndrome (PCOS) is a chronic endocrinopathy characterized by oligo- or anovulation, clinical and/or biochemical markers of hyperandrogenism, and polycystic ovaries, and it is associated with an increased prevalence of depression. Research conducted on psychiatric patients has shown correlations between depression and decreased cognitive function. The aim of this study was to examine the possible mediation of the time perspective (TP) in the development of depressive symptoms in patients with PCOS...
March 30, 2023: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/37031588/the-frequency-and-macromorphological-classification-of-abnormal-blood-vessel-impressions-and-periosteal-appositions-of-the-dura-mater-in-an-early-modern-osteological-collection-from-poland
#32
JOURNAL ARTICLE
Joanna Wysocka, Agata Cieślik
OBJECTIVE: The macromorphological characteristics and frequency of endocranial abnormal blood vessel impressions (ABVI) and periosteal appositions of dura mater (PADM), and their association with sex, age-at-death and scurvy-like lesions were studied. The possible etiologies of these lesions were discussed. MATERIALS: A total of 144 adult skulls excavated from an early modern (16th-19th c. CE) cemetery at the Czysty Square in Wrocław (Poland) were examined, most of which were intact...
April 7, 2023: International Journal of Paleopathology
https://read.qxmd.com/read/37024583/precise-modulation-of-transcription-factor-levels-identifies-features-underlying-dosage-sensitivity
#33
JOURNAL ARTICLE
Sahin Naqvi, Seungsoo Kim, Hanne Hoskens, Harold S Matthews, Richard A Spritz, Ophir D Klein, Benedikt Hallgrímsson, Tomek Swigut, Peter Claes, Jonathan K Pritchard, Joanna Wysocka
Transcriptional regulation exhibits extensive robustness, but human genetics indicates sensitivity to transcription factor (TF) dosage. Reconciling such observations requires quantitative studies of TF dosage effects at trait-relevant ranges, largely lacking so far. TFs play central roles in both normal-range and disease-associated variation in craniofacial morphology; we therefore developed an approach to precisely modulate TF levels in human facial progenitor cells and applied it to SOX9, a TF associated with craniofacial variation and disease (Pierre Robin sequence (PRS))...
May 2023: Nature Genetics
https://read.qxmd.com/read/36996812/structural-elements-promote-architectural-stripe-formation-and-facilitate-ultra-long-range-gene-regulation-at-a-human-disease-locus
#34
JOURNAL ARTICLE
Liang-Fu Chen, Hannah Katherine Long, Minhee Park, Tomek Swigut, Alistair Nicol Boettiger, Joanna Wysocka
Enhancer clusters overlapping disease-associated mutations in Pierre Robin sequence (PRS) patients regulate SOX9 expression at genomic distances over 1.25 Mb. We applied optical reconstruction of chromatin architecture (ORCA) imaging to trace 3D locus topology during PRS-enhancer activation. We observed pronounced changes in locus topology between cell types. Subsequent analysis of single-chromatin fiber traces revealed that these ensemble-average differences arise through changes in the frequency of commonly sampled topologies...
March 22, 2023: Molecular Cell
https://read.qxmd.com/read/36983153/selected-serum-markers-associated-with-pathogenesis-and-clinical-course-of-type-1-diabetes-in-pediatric-patients-the-effect-of-disease-duration
#35
JOURNAL ARTICLE
Agnieszka Ochocińska, Marta Wysocka-Mincewicz, Jolanta Świderska, Bożena Cukrowska
Biochemical abnormalities in the course of type 1 diabetes (T1D) may cause the production/activation of various proteins and peptides influencing treatment and causing a risk of complications. The aim of this study was to assess concentrations of selected serum substances involved in the pathogenesis and course of T1D and to correlate their concentrations with the duration of T1D. The study included patients with T1D ( n = 156) at the age of 3-17, who were divided according to the duration of the disease into those newly diagnosed ( n = 30), diagnosed after 3-5 ( n = 77), 6-7 ( n = 25), and over 7 ( n = 24) years from the onset of T1D, and age-matched healthy controls ( n = 30)...
March 9, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/36952092/correction-high-light-inducible-proteins-hlia-and-hlib-pigment-binding-and-protein-protein-interactions
#36
Minna M Konert, Anna Wysocka, Peter Koník, Roman Sobotka
No abstract text is available yet for this article.
March 23, 2023: Photosynthesis Research
https://read.qxmd.com/read/36951492/theory-of-mind-and-parental-mental-state-talk-in-children-with-cis
#37
JOURNAL ARTICLE
Agnieszka Pluta, Magdalena Krysztofiak, Małgorzata Zgoda, Joanna Wysocka, Karolina Golec, Katarzyna Gajos, Tadeusz Dołyk, Tomasz Wolak, Maciej Haman
Previous studies have suggested that parents may support the development of theory of mind (ToM) in their child by talking about mental states (mental state talk; MST). However, MST has not been sufficiently explored in deaf children with cochlear implants (CIs). This study investigated ToM and availability of parental MST in deaf children with CIs (n = 39, Mage = 62.92, SD = 15.23) in comparison with their peers with typical hearing (TH; n = 52, Mage = 52...
March 23, 2023: Journal of Deaf Studies and Deaf Education
https://read.qxmd.com/read/36837399/asymptomatic-bacteriuria-in-kidney-transplant-recipients-a-narrative-review
#38
REVIEW
Justyna E Gołębiewska, Beata Krawczyk, Magdalena Wysocka, Aleksandra Dudziak, Alicja Dębska-Ślizień
Urinary tract infections (UTIs) are the most prevalent complications in kidney transplant (KTx) recipients. The most frequent finding in this group of patients is asymptomatic bacteriuria (ASB). Here, we provide an overview of the available evidence regarding ASB in KTx recipients, including its etiopathology, clinical impact and management. There is a growing body of evidence from clinical trials that screening for and treating ASB is not beneficial in most KTx recipients. However, there are insufficient data to recommend or discourage the use of a "screen-and-treat strategy" for ASB during the first 1-2 months post-transplant or in the case of an indwelling urinary catheter...
January 19, 2023: Medicina
https://read.qxmd.com/read/36835040/matrix-metalloproteinases-in-cardioembolic-stroke-from-background-to-complications
#39
REVIEW
Anna Wysocka, Jacek Szczygielski, Marta Kopańska, Joachim M Oertel, Andrzej Głowniak
Matrix metalloproteinases (MMPs) are endopeptidases participating in physiological processes of the brain, maintaining the blood-brain barrier integrity and playing a critical role in cerebral ischemia. In the acute phase of stroke activity, the expression of MMPs increase and is associated with adverse effects, but in the post-stroke phase, MMPs contribute to the process of healing by remodeling tissue lesions. The imbalance between MMPs and their inhibitors results in excessive fibrosis associated with the enhanced risk of atrial fibrillation (AF), which is the main cause of cardioembolic strokes...
February 11, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36834417/effect-of-physical-activity-on-static-and-dynamic-postural-balance-in-women-treated-for-breast-cancer-a-systematic-review
#40
REVIEW
Aleksandra Bula, Karolina Tatar, Regina Wysocka, Kasper Chyrek, Laura Piejko, Agnieszka Nawrat-Szołtysik, Anna Polak
BACKGROUND: Therapies against breast cancer (BC) frequently involve complications that impair patients' daily function and quality of life, the most common of which are motor coordination and balance disorders, increasing the risk of falls and injuries. In such cases, physical activity is recommended. Designed following the PRISMA guidelines, this study presents a systematic review of randomised and pilot clinical trials investigating the effect of physical exercises on postural balance in women treated for BC...
February 20, 2023: International Journal of Environmental Research and Public Health
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