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https://www.readbyqxmd.com/read/29699766/factors-associated-with-preservation-of-c-peptide-levels-at-the-diagnosis-of-type-1-diabetes
#1
Agnieszka Szypowska, Lidia Groele, Marta Wysocka-Mincewicz, Artur Mazur, Lucyna Lisowicz, Iwona Ben-Skowronek, Joanna Sieniawska, Bożenna Klonowska, Dorota Charemska, Jolanta Nawrotek, Irena Jałowiec, Artur Bossowski, Klaudyna Noiszewska, Beata Pyrżak, Izabela Rogozińska, Mieczysław Szalecki
AIMS: The level of C-peptide can identify individuals most likely to respond to immune interventions carried out to prevent pancreatic β-cell damage. The aim of the study was to evaluate factors associated with C-peptide levels at type 1 diabetes (T1D) diagnosis. METHODS: This study included 1098 children aged 2-17 with newly recognized T1D. Data were collected from seven Polish hospitals. The following variables were analyzed: date of birth, fasting C-peptide, HbA1c, sex, weight, height, pH at diabetes onset...
March 23, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29655493/hepatic-inflammatory-pseudotumor-related-with-igg4
#2
Oleksandr Legkiy, Justyna Wajda, Anna Ćwierz, Joanna Wysocka, Andrzej L Komorowski
BACKGROUND: Hepatic inflammatory pseudotumor (HIP) related to IgG4 is a poorly understood entity. It is a rare finding that can simulate malignant liver tumors. Pathogenesis has been associated with pathological inflammatory response. Corticosteroids are considered standard of care once a firm diagnosis has been established. CASE REPORT: We report a case of a 60-year-old man with chronic pancreatitis who was admitted to our hospital with suspicious liver tumor. Imaging studies were inconclusive...
April 11, 2018: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29624000/the-occurrence-of-dynamic-structural-disorders-in-the-pharynx-and-larynx-at-rest-and-during-exercise-in-horses-diagnosed-with-mild-and-moderate-equine-asthma-inflammatory-airway-disease
#3
B Wysocka, W Kluciński
The goal of the present study was to establish the occurrence of structural disorders in the larynx and pharynx during treadmill exercise tests in horses diagnosed with Equine Asthma (EA). Investigation was performed in 29 horses, patients of the Equine Clinic of the Warsaw University of Life Sciences in Poland, admitted with poor exercise performance. Upper and lower airway examinations were performed in all patients revealing both mild to moderate Equine Asthma (13 horses), and no lower airway abnormalities (16 animals)...
March 2018: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29611640/influence-of-simvastatin-on-red-blood-cell-line-in-porcine-bone-marrow
#4
A Snarska, S Gonkowski, L Rytel, A Pomianowski, I Babińska, I Otrocka-Domagała, K Żarczyńska, D Wysocka, P Sobiech
Simvastatin is a drug commonly used to reduce the cholesterol level. 32 clinically healthy female pigs with a bodyweight of 35-40 kg, kept in standard laboratory conditions were chosen for the experiment and divided into 2 groups (control and experimental) consisting of 16 animals. The experimental group received simvastatin orally at a dose of 40 mg (one tablet once a day) for 56 days, and at the same time the control group received placebo (empty gelatin capsules). Bone marrow smears and peripheral blood samples were evaluated...
December 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29578476/urinary-incontinence-due-to-lumbar-spinal-stenosis-causing-disability-and-lowering-quality-of-life
#5
Aleksandra Truszczyńska-Baszak, Edyta Wysocka, Małgorzata Starzec, Justyna Drzał-Grabiec, Adam Tarnowski
OBJECTIVES: Lumbar spinal stenosis may lead to urinary inconsistence and negatively impact quality of life. The aim of the study was to assess the incidence of urinary incontinence and quality of life in female patients with spinal canal stenosis comparing to control group. METHODS: The study population consisted of 50 women diagnosed with severe lumbar spinal canal stenosis. Their mean age was 55.32 ± 12.97 years. The clinical control group consisted of 30 women who did not suffer from any spine disorders...
March 16, 2018: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29558031/interleukin-6-osteoprotegerin-srankl-and-bone-metabolism-in-inflammatory-bowel-diseases
#6
Iwona Krela-Kaźmierczak, Aleksandra Szymczak-Tomczak, Liliana Łykowska-Szuber, Ewa Wysocka, Michał Michalak, Kamila Stawczyk-Eder, Katarzyna Waszak, Krzysztof Linke, Piotr Eder
BACKGROUND: Cytokines are mediators of inflammatory processes in the course of inflammatory bowel disease (IBD) and participate in the bone metabolism. Interleukin 6 (IL-6) initiates osteoclastogenesis by modulating the activity of soluble receptor activator of nuclear factor kappa B ligand (sRANKL) and osteoprotegerin. OBJECTIVES: The aim of the study was to evaluate bone mineral density (BMD) by densitometry and the concentration of interleukin 6, osteoprotegerin (OPG) and sRANKL protein (sRANKL) by ELISA in patients with IBD in relation to the control group; to assess the relationship between IL-6, OPG, sRANKL and BMD; and to assess the impact of disease duration and number hospitalization on BMD...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29523408/tg-hdl-c-ratio-and-visceral-adiposity-index-may-be-useful-in-assessment-of-insulin-resistance-in-adults-with-type-1-diabetes-in-clinical-practice
#7
Aleksandra Uruska, Dorota Zozulinska-Ziolkiewicz, Pawel Niedzwiecki, Monika Pietrzak, Bogna Wierusz-Wysocka
BACKGROUND: Insulin resistance (IR) is an important clinical issue in patients with type 1 diabetes due to worse metabolic control and risk of development of chronic complications. OBJECTIVE: The aim of the study was to evaluate simple and easily available parameters as indirect markers of IR in adults with type 1 diabetes and correlate it with the results of hyperinsulinemic-euglycemic clamp. METHODS: The study included 88 patients (62 men), aged 34...
January 31, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29517181/the-occurrence-of-resveratrol-in-foodstuffs-and-its-potential-for-supporting-cancer-prevention-and-treatment-a-review
#8
Ewa Dybkowska, Anna Sadowska, Franciszek Świderski, Rita Rakowska, Katarzyna Wysocka
Over recent years, there has been increasing interest noted in those active substances derived from plants that show potential for preventing cancer development. The most promising candidate is resveratrol which can be found in large amounts in the skin of grapes, tomatoes and in red wine. Its beneficial effects on the human body are seen both in prevention and therapy. The anti-carcinogenic action of resveratrol is linked with its ability to neutralise reactive oxygen species and to modulate cellular processes such as apoptosis, and both cancerous cell proliferation and differentiation...
2018: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/29507566/oncogenic-braf-mutations-and-p16-expression-in-melanocytic-nevi-and-melanoma-in-the-polish-population
#9
Małgorzata Mackiewicz-Wysocka, Patrycja Czerwińska, Violetta Filas, Elżbieta Bogajewska, Agata Kubicka, Anna Przybyła, Ewelina Dondajewska, Tomasz Kolenda, Andrzej Marszałek, Andrzej Mackiewicz
Introduction: Twenty-five - fifty percent of skin melanomas arise from nevi. Melanocyte proliferation is activated by BRAF V600E , then is arrested, but single nevi transform to melanomas. p16 controls arrest, and p16 loss may promote transformation. Aim: To analyze BRAF V600E , p16 expression and melanocyte proliferation in dermal, compound and dysplastic nevi, cells of primary and metastatic melanoma in the Polish population. Material and methods: One hundred and thirty-two nevi (dermal, compound, dysplastic) and 41 melanomas ( in situ , primary, metastatic) were studied...
October 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29506312/seasonal-variation-in-month-of-diagnosis-of-polish-children-with-type-1-diabetes-a-multicenter-study
#10
Agnieszka Szypowska, Anna Ramotowska, Marta Wysocka-Mincewicz, Artur Mazur, Lucyna Lisowicz, Iwona Beń-Skowronek, Joanna Sieniawska, Bożenna Klonowska, Dorota Charemska, Jolanta Nawrotek, Irena Jałowiec, Artur Bossowski, Milena Jamiołkowska, Beata Pyrżak, Grażyna Miszkurka, Mieczysław Szalecki
AIM: The seasonal variation of incidence of type 1 diabetes (T1D) theory supports the hypothesis that environmental factors play a role in the onset of the disease. The aim of this study is to assess seasonality of month of diagnosis in children with T1D in Poland. MATERIAL AND METHODS: the study group consisted of 2174 children from eastern and central Poland diagnosed with T1D between 2010 and 2014. Analysis was performed in different age groups, based on place of residence (rural/urban area) and depending on sex...
March 5, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29505511/cardiovascular-risk-factors-in-patients-with-combined-central-retinal-vein-occlusion-and-cilioretinal-artery-occlusion-case-report
#11
Andrzej Grzybowski, Waldemar Elikowski, Magdalena Gaca-Wysocka
RATIONALE: To analyze cardiovascular risk factors and comorbidity of acute unilateral visual loss due to combined central retinal vein occlusion (CRVO) and cilioretinal artery occlusion (CLRAO). PATIENT CONCERNS: Among patients with retinal vein or artery occlusion hospitalized at the Department of Ophthalmology between January 2011 and August 2017, subjects with combined CRVO/CLRAO were selected. All of them underwent ophthalmologic and cardiologic examination, including fluorescein angiography, optical coherence tomography, 12-lead electrocardiogram, transthoracic and transesophageal echocardiography, carotid Doppler sonography, cerebral magnetic resonance imaging, and a panel of laboratory tests...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29497152/histone-h3-lysine-4-monomethylation-modulates-long-range-chromatin-interactions-at-enhancers
#12
Jian Yan, Shi-An A Chen, Andrea Local, Tristin Liu, Yunjiang Qiu, Kristel M Dorighi, Sebastian Preissl, Chloe M Rivera, Chaochen Wang, Zhen Ye, Kai Ge, Ming Hu, Joanna Wysocka, Bing Ren
This corrects the article DOI: 10.1038/cr.2018.1.
March 2018: Cell Research
https://www.readbyqxmd.com/read/29459680/genome-wide-mapping-of-global-to-local-genetic-effects-on-human-facial-shape
#13
Peter Claes, Jasmien Roosenboom, Julie D White, Tomek Swigut, Dzemila Sero, Jiarui Li, Myoung Keun Lee, Arslan Zaidi, Brooke C Mattern, Corey Liebowitz, Laurel Pearson, Tomás González, Elizabeth J Leslie, Jenna C Carlson, Ekaterina Orlova, Paul Suetens, Dirk Vandermeulen, Eleanor Feingold, Mary L Marazita, John R Shaffer, Joanna Wysocka, Mark D Shriver, Seth M Weinberg
Genome-wide association scans of complex multipartite traits like the human face typically use preselected phenotypic measures. Here we report a data-driven approach to phenotyping facial shape at multiple levels of organization, allowing for an open-ended description of facial variation while preserving statistical power. In a sample of 2,329 persons of European ancestry, we identified 38 loci, 15 of which replicated in an independent European sample (n = 1,719). Four loci were completely new. For the others, additional support (n = 9) or pleiotropic effects (n = 2) were found in the literature, but the results reported here were further refined...
March 2018: Nature Genetics
https://www.readbyqxmd.com/read/29414572/magnetic-polymer-microcapsules-loaded-with-nile-red-fluorescent-dye
#14
Marta Bartel, Barbara Wysocka, Pamela Krug, Daria Kępińska, Krystyna Kijewska, Gary J Blanchard, Katarzyna Kaczyńska, Katarzyna Lubelska, Katarzyna Wiktorska, Paulina Głowala, Marcin Wilczek, Marcin Pisarek, Jacek Szczytko, Andrzej Twardowski, Maciej Mazur
Fabrication of multifunctional smart vehicles for drug delivery is a fascinating challenge of multidisciplinary research at the crossroads of materials science, physics and biology. We demonstrate a prototypical microcapsule system that is capable of encapsulating hydrophobic molecules and at the same time reveals magnetic properties. The microcapsules are prepared using a templated synthesis approach where the molecules to be encapsulated (Nile Red) are present in the organic droplets that are suspended in the polymerization solution which also contains magnetic nanoparticles...
April 15, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29403261/maximum-human-objectively-measured-pharmacologically-stimulated-accommodative-amplitude
#15
Andrzej Grzybowski, Ronald A Schachar, Magdalena Gaca-Wysocka, Ira H Schachar, Barbara K Pierscionek
Purpose: To measure the maximum, objectively measured, accommodative amplitude, produced by pharmacologic stimulation. Methods: Thirty-seven healthy subjects were enrolled, with a mean age of 20.2±1.1 years, corrected visual acuity of 20/20, and mean spherical equivalent refraction (SER) =-0.83±1.60 diopters. For each subject, the right pupil was dilated with phenylephrine 10%. After 30 minutes, the pupil was measured, the left eye was patched, and the right eye was autorefracted...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29371426/transcription-coupled-changes-in-nuclear-mobility-of-mammalian-cis-regulatory-elements
#16
Bo Gu, Tomek Swigut, Andrew Spencley, Matthew R Bauer, Mingyu Chung, Tobias Meyer, Joanna Wysocka
To achieve guide RNA (gRNA) multiplexing and an efficient delivery of tens of distinct gRNAs into single cells, we developed a molecular assembly strategy termed chimeric array of gRNA oligonucleotides (CARGO). We coupled CARGO with dCas9 (catalytically dead Cas9) imaging to quantitatively measure the movement of enhancers and promoters that undergo differentiation-associated activity changes in live embryonic stem cells. Whereas all examined functional elements exhibited subdiffusive behavior, their relative mobility increased concurrently with transcriptional activation...
March 2, 2018: Science
https://www.readbyqxmd.com/read/29364875/tissue-selective-effects-of-nucleolar-stress-and-rdna-damage-in-developmental-disorders
#17
Eliezer Calo, Bo Gu, Margot E Bowen, Fardin Aryan, Antoine Zalc, Jialiang Liang, Ryan A Flynn, Tomek Swigut, Howard Y Chang, Laura D Attardi, Joanna Wysocka
Many craniofacial disorders are caused by heterozygous mutations in general regulators of housekeeping cellular functions such as transcription or ribosome biogenesis. Although it is understood that many of these malformations are a consequence of defects in cranial neural crest cells, a cell type that gives rise to most of the facial structures during embryogenesis, the mechanism underlying cell-type selectivity of these defects remains largely unknown. By exploring molecular functions of DDX21, a DEAD-box RNA helicase involved in control of both RNA polymerase (Pol) I- and II-dependent transcriptional arms of ribosome biogenesis, we uncovered a previously unappreciated mechanism linking nucleolar dysfunction, ribosomal DNA (rDNA) damage, and craniofacial malformations...
February 1, 2018: Nature
https://www.readbyqxmd.com/read/29316667/uv-vis-induced-degradation-of-phenol-over-magnetic-photocatalysts-modified-with-pt-pd-cu-and-au-nanoparticles
#18
Izabela Wysocka, Ewa Kowalska, Konrad Trzciński, Marcin Łapiński, Grzegorz Nowaczyk, Anna Zielińska-Jurek
The combination of TiO₂ photocatalyst and magnetic oxide nanoparticles enhances the separation and recoverable properties of nanosized TiO₂ photocatalyst. Metal-modified (Me = Pd, Au, Pt, Cu) TiO₂/SiO₂@Fe₃O₄ nanocomposites were prepared by an ultrasonic-assisted sol-gel method. All prepared samples were characterized by X-ray powder diffraction (XRD) analysis, Brunauer-Emmett-Teller (BET) method, X-ray photoelectron spectroscopy (XPS), scanning transmission electron microscopy (STEM), Mott-Schottky analysis and photoluminescence spectroscopy (PL)...
January 7, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29313530/histone-h3-lysine-4-monomethylation-modulates-long-range-chromatin-interactions-at-enhancers
#19
Jian Yan, Shi-An A Chen, Andrea Local, Tristin Liu, Yunjiang Qiu, Kristel M Dorighi, Sebastian Preissl, Chloe M Rivera, Chaochen Wang, Zhen Ye, Kai Ge, Ming Hu, Joanna Wysocka, Bing Ren
Long-range chromatin interactions between enhancers and promoters are essential for transcription of many developmentally controlled genes in mammals and other metazoans. Currently, the exact mechanisms that connect distal enhancers to their specific target promoters remain to be fully elucidated. Here, we show that the enhancer-specific histone H3 lysine 4 monomethylation (H3K4me1) and the histone methyltransferases MLL3 and MLL4 (MLL3/4) play an active role in this process. We demonstrate that in differentiating mouse embryonic stem cells, MLL3/4-dependent deposition of H3K4me1 at enhancers correlates with increased levels of chromatin interactions, whereas loss of this histone modification leads to reduced levels of chromatin interactions and defects in gene activation during differentiation...
February 2018: Cell Research
https://www.readbyqxmd.com/read/29289303/determination-of-ultra-trace-level-of-232-th-in-seawater-by-icp-sfms-after-matrix-separation-and-preconcentration
#20
Irena Wysocka, Emilia Vassileva
This article describes the development and validation of an analytical procedure for the matrix separation, preconcentration and determination of sub-ng kg-1 levels232 Th in a small volume (20 mL) of seawater samples. The matrix separation and Th preconcentration was carried out using a commercially available ion-chelation system seaFAST-pico. The acidified to pH < 2 seawater samples were mixed on-line with the ammonium acetate buffer (pH of 6.0 ± 0.2) before loading on the column containing resin with iminodiacetic and ethylenediaminetriacetic functional groups...
February 13, 2018: Analytica Chimica Acta
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