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Agnieszka Szypowska, Katarzyna Dżygało, Marta Wysocka-Mincewicz, Artur Mazur, Lucyna Lisowicz, Iwona Ben-Skowronek, Joanna Sieniawska, Bożenna Klonowska, Dorota Charemska, Jolanta Nawrotek, Irena Jałowiec, Artur Bossowski, Milena Jamiołkowska, Beata Pyrżak, Izabela Rogozińska, Mieczysław Szalecki
AIM: Despite its characteristic symptoms, type 1 diabetes (T1D) is still diagnosed late causing the development of diabetic ketoacidosis (DKA). The aim of this study was to estimate the incidence of DKA and factors associated with the development of acidosis at T1D recognition in Polish children aged 0-17. METHODS: The study population consisted of 2100 children with newly diagnosed T1D in the years 2010-2014 in 7 hospitals in eastern and central Poland. The population living in these areas accounts for 35% of the Polish population...
October 11, 2016: Pediatric Diabetes
Ilona Kurnatowska, Aneta Małyska, Kamila Wysocka, Katarzyna Mazur, Joanna Krawczyk, Michał Nowicki
BACKGROUND Both adiposity and underweight are negatively associated with graft and patient survival after kidney transplantation (KTx). The aim of this longitudinal study was to evaluate the changes in body mass index (BMI) after KTx and their relations with graft damage markers. MATERIAL AND METHODS The anthropometric measurements of body mass and height were performed in 92 consecutive deceased donor kidney transplant recipients (37 F; 55 M) from a single transplant center. Patient medical history, estimated glomerular filtration rate (eGFR), serum lipids, and ACR (urine albumin-to-creatinine ratio) was obtained from medical charts...
October 11, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
Olga Wysocka, Julita Kulbacka, Jolanta Saczko
Pancreatic cancer is one of the most aggressive and deadly malignancies. Despite better understanding of its biology and pathogenesis, contemporary treatment regimens are still insufficient. Along with the introduction of new treatment agents and combination therapy, the response rates are increasing, but these scores do not go with overall survival, and results are frequently conflicting. Therefore, contemporary medicine faces the challenge of expanding the knowledge base and practice on all grounds - pathology, factor risk, diagnosis, and finally surgical and palliative treatment of this disease...
2016: Przegla̜d Gastroenterologiczny
Nicholas L Bayless, Rachel S Greenberg, Tomek Swigut, Joanna Wysocka, Catherine A Blish
Zika virus (ZIKV) infection during pregnancy is linked to microcephaly, which is attributed to infection of developing brain structures. ZIKV infects neural progenitor cells in vitro, though its effects on other developmentally relevant stem cell populations, including cranial neural crest cells (CNCCs), have not been assessed. CNCCs give rise to most cranial bones and exert paracrine effects on the developing brain. Here, we report that CNCCs are productively infected by ZIKV, but not by the related dengue virus...
October 12, 2016: Cell Host & Microbe
Sylwia Dzięgielewska-Gęsiak, Lena Bielawska, Miłosława Zowczak-Drabarczyk, Karolina Hoffmann, Maciej Cymerys, Małgorzata Muc-Wierzgoń, Ewa Wysocka, Wiesław Bryl
INTRODUCTION    There is an inverse relationship between high density lipoprotein cholesterol concentration and risk of atherosclerosis.  OBJECTIVES    The aim of the study was to assess an oxidant-antioxidant balance in elderly subjects with different concentrations of high density lipoprotein cholesterol. PATIENTS AND METHODS    541 elderly persons ≥ 60 years were investigated. 90 of them, with no acute or severe chronic disorder were assessed:  waist circumference (WC), body mass index (BMI), percentage of body fat (FAT) and blood pressure...
September 20, 2016: Polskie Archiwum Medycyny Wewnętrznej
Iwona Krela-Kaźmierczak, Marta Kaczmarek-Ryś, Aleksandra Szymczak, Michał Michalak, Marzena Skrzypczak-Zielińska, Natalia Drwęska-Matelska, Michalina Marcinkowska, Piotr Eder, Lilianna Łykowska-Szuber, Ewa Wysocka, Krzysztof Linke, Ryszard Słomski
Osteoporosis is more frequent in inflammatory bowel disease (IBD) patients. A reduction in bone mineral mass in these individuals is caused not only by inflammatory processes in the bowel, because osteoporosis occurs already in very young IBD patients and in newly diagnosed individuals who have not yet undergone any pharmacological treatment. One of individual determinants of the bone turnover parameters is osteoprotegerin (OPG) encoded by the TNFRSF11B gene. The c.-223C > T polymorphism in this gene has been extensively studied in post-menopausal osteoporosis patients...
September 17, 2016: Calcified Tissue International
Dinar Yunusov, Leticia Anderson, Lucas Ferreira DaSilva, Joanna Wysocka, Toshihiko Ezashi, R Michael Roberts, Sergio Verjovski-Almeida
Eukaryotic genomes are transcribed into numerous regulatory long non-coding RNAs (lncRNAs). Compared to mRNAs, lncRNAs display higher developmental stage-, tissue-, and cell-subtype-specificity of expression, and are generally less abundant in a population of cells. Despite the progress in single-cell-focused research, the origins of low population-level expression of lncRNAs in homogeneous populations of cells are poorly understood. Here, we identify HIPSTR (Heterogeneously expressed from the Intronic Plus Strand of the TFAP2A-locus RNA), a novel lncRNA gene in the developmentally regulated TFAP2A locus...
2016: Scientific Reports
Neha Jariwala, Bernice Benoit, Andrew V Kossenkov, Landon K Oetjen, Timothy M Whelan, Christine M Cornejo, Junko Takeshita, Brian S Kim, Louise C Showe, Maria Wysocka, Alain H Rook
No abstract text is available yet for this article.
September 1, 2016: Journal of Investigative Dermatology
Paweł Burchardt, Agnieszka Zawada, Jolanta Kaczmarek, Justyna Marcinkaniec, Henryk Wysocki, Bogna Wierusz-Wysocka, Marian Grzymisławski, Janusz Rzeźniczak, Dorota Zozulińska-Ziółkiewicz, Dariusz Naskręt
INTRODUCTION    Lipoprotein-associated phospholipase A2 (Lp-PLA2) and cholesteryl ester lipase (CEL) may oxidize low-density lipoproteins (oxLDL). OBJECTIVES    The aim of the study was to determine the influence of metformin on the metabolism of atherogenic lipid fractions in relation to Lp-PLA2 and CEL levels, as well as assess consequent improvement in the intima-media thickness (IMT) of the common carotid artery in young type 1 diabetes patients with excess body fat. PATIENTS AND METHODS    It was an open-label randomized clinical trial that lasted 6 months...
August 25, 2016: Polskie Archiwum Medycyny Wewnętrznej
Mohammed A Amin, Emad M Ahmed, Nasser Y Mostafa, Mona M Alotibi, Gitashree Darabdhara, Manash R Das, Joanna Wysocka, Jacek Ryl, Sayed S Abd El-Rehim
In this paper, we demonstrated, for the first time, aluminum titania nanoparticle (Al-TiO2 NP) composites with variable amounts of TiO2 NPs as nonprecious active catalysts for the electrochemical generation of H2. These materials were synthesized by mixing desired amounts of hydrogen titanate nanotubes (TNTs), fabricated here by a cost-effective approach at moderate hydrothermal conditions, with aluminum powder (purity 99.7%; size 35 μm). The mixture was compacted under an applied uniaxial stress of 300 MPa followed by sintering at 500 °C for 1 h...
September 14, 2016: ACS Applied Materials & Interfaces
Anna Adamska, Michalina Nowak, Stanisław Piłaciński, Aleksandra Araszkiewicz, Monika Litwinowicz, Małgorzata Tomaszewska, Bogna Wierusz-Wysocka, Marian Grzymisławski, Dorota Zozulińska-Ziółkiewicz
INTRODUCTION Gastrointestinal symptoms may occur in 50% to 70% of patients with diabetes. OBJECTIVES The aim of this study was to evaluate the prevalence of small intestinal bacterial overgrowth (SIBO) in patients with diabetes, as well as the relationship between SIBO and metabolic control of diabetes and the presence of chronic complications of the disease. PATIENTS AND METHODS The study group included 148 patients with type 1 diabetes, treated in the years 2013-2015. The control group consisted of 41 healthy volunteers...
August 18, 2016: Polskie Archiwum Medycyny Wewnętrznej
Amy L Klocko, Ewa Borejsza-Wysocka, Amy M Brunner, Olga Shevchenko, Herb Aldwinckle, Steven H Strauss
We investigated the ability of RNA interference (RNAi) directed against two co-orthologs of AGAMOUS (AG) from Malus domestica (domestic apple, MdAG) to reduce the risks of invasiveness and provide genetic containment of transgenes, while also promoting the attractiveness of flowers for ornamental usage. Suppression of two MdAG-like genes, MdMADS15 and MdMADS22, led to the production of trees with highly showy, polypetalous flowers. These "double-flowers" had strongly reduced expression of both MdAG-like genes...
2016: PloS One
Anna Zielińska-Jurek, Zuzanna Bielan, Izabela Wysocka, Judyta Strychalska, Marcin Janczarek, Tomasz Klimczuk
In the present study treatability of persistent organic compounds from the flow back water after hydrauling fracturing was investigated. The combination of TiO2 photocatalyst and magnetic oxide nanoparticles enhance the separation and recoverable property of nanosized TiO2 photocatalyst. Fe3O4/TiO2 and Fe3O4@SiO2/TiO2 nanocomposites were prepared by heteroagglomeration. The photocatalysts' characteristics by X-ray diffractometry (XRD), scanning electron microscopy (SEM), diffuse reflectance spectroscopy (DRS) showed that sample with the mass ratio of Fe3O4 to TiO2 equal 1:4 and molar ratio of TEOS:Fe3O4 = 8:1 and NH4OH:TEOS = 16:1 obtained by deposition TiO2 P25 (Evonik) on magnetite core had about 124 m(2) g(-1) specific surface area and superparamagnetic properties...
July 6, 2016: Journal of Environmental Management
Brice Korkmaz, Adam Lesner, Carla Guarino, Magdalena Wysocka, Christine Kellenberger, Hervé Watier, Ulrich Specks, Francis Gauthier, Dieter E Jenne
Proteinase 3 (PR3) has received great scientific attention after its identification as the essential antigenic target of antineutrophil cytoplasm antibodies in Wegener's granulomatosis (now called granulomatosis with polyangiitis). Despite many structural and functional similarities between neutrophil elastase (NE) and PR3 during biosynthesis, storage, and extracellular release, unique properties and pathobiological functions have emerged from detailed studies in recent years. The development of highly sensitive substrates and inhibitors of human PR3 and the creation of PR3-selective single knockout mice led to the identification of nonredundant roles of PR3 in cell death induction via procaspase-3 activation in cell cultures and in mouse models...
July 2016: Pharmacological Reviews
Natalia Gruba, Magdalena Wysocka, Magdalena Brzezińska, Dawid Dębowski, Marcin Sieńczyk, Ewa Gorodkiewicz, Tomasz Guszcz, Cezary Czaplewski, Krzysztof Rolka, Adam Lesner
The 20S catalytic core of the human 26S proteasome can be secreted from cells, and high levels of extracellular 20S proteasome have been linked to many types of cancers and autoimmune diseases. Several diagnostic approaches have been developed that detect 20S proteasome activity in plasma, but these suffer from problems with efficiency and sensitivity. In this report, we describe the optimization and synthesis of an internally quenched fluorescent substrate of the 20S proteasome, and investigate its use as a potential diagnostic test in bladder cancer...
August 2016: FEBS Journal
Krystyna Pyrzynska, Anna Kubiak, Irena Wysocka
Determination of rare earth elements in environmental samples requires often pre-concentration and separation step due to a low metal content and high concentration of the interfering matrix components. A solid phase extraction technique with different kind of solid sorbents offers a high enrichment factor, rapid phase separation and the possibility of its combination with various detection techniques used either in on-line or off-line mode. The recent developments in this area published over the last five years are presented and discussed in this paper...
July 1, 2016: Talanta
Anna Socha-Banasiak, Barbara Kamer, Agnieszka Gach, Urszula Wysocka, Lucjusz Jakubowski, Ewa Głowacka, Elżbieta Czkwianianc
PURPOSE: This study aimed to investigate early-life folate serum concentrations in children with food, inhalant or mixed type allergy. The influence of folate levels on the FoxP3 expression in Treg (regulatory T) cells in the studied children, taking into account the MTHFR (5,10-methylenetetrahydrofolate reductase) genotypes was also analyzed. MATERIAL AND METHODS: The study was performed in 83 allergic children (study group) and 49 healthy children (control group), aged 2-72 months...
April 8, 2016: Advances in Medical Sciences
Iwona Krela-Kaźmierczak, Ewa Wysocka, Aleksandra Szymczak, Piotr Eder, Michał Michalak, Liliana Łykowska-Szuber, Kamila Stawczyk-Eder, Katarzyna Klimczak, Krzysztof Linke, Wanda Horst-Sikorska
INTRODUCTION: Crohn's disease (CD) promotes the development of osteopaenia/osteoporosis, the cytokine background of which is not fully known. AIM: Evaluation of bone mineral density (BMD), the prevalence of osteopaenia and osteoporosis, and the determination of the levels of selected interleukins (IL), osteoprotegerin (OPG), and s-RANKL proteins in patients with CD in relation to a control group and assessment of the relationship between the tested cytokines, OPG, s-RANKL, and BMD...
2016: Przegla̜d Gastroenterologiczny
Katarzyna Pawlak-Buś, Magdalena Gaca-Wysocka, Andrzej Grzybowski, Piotr Leszczyński
Anti-malarial drugs specifically hydroxychloroquine (HCQ) or chloroquine (CQ) are very effective in treating and preventing the symptoms of systemic lupus erythematosus and other connective tissue diseases. These medications have shown to improve joint and muscle pain and arthritis, skin rashes, fatique, fever and also to control systemic signs of lupus as pericarditis or pleuritis. Shortterm and long-term treatment reduce cholesterol and have anti-platelet effect with decreasing risk of cardiovascular disease...
March 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Magdalena Wysocka, Natalia Gruba, Renata Grzywa, Artur Giełdoń, Remigiusz Bąchor, Krzysztof Brzozowski, Marcin Sieńczyk, Jenne Dieter, Zbigniew Szewczuk, Krzysztof Rolka, Adam Lesner
Herein we present the synthesis of a novel type of peptidomimetics composed of repeating diaminopropionic acid residues modified with structurally diverse heterobifunctional polyethylene glycol chains (abbreviated as DAPEG). Based on the developed compounds, a library of fluorogenic substrates was synthesized. Further library deconvolution towards human neutrophil serine protease 4 (NSP4) yielded highly sensitive and selective internally quenched peptidomimetic substrates. In silico analysis of the obtained peptidomimetics revealed the presence of an interaction network with distant subsites located on the enzyme surface...
2016: Scientific Reports
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