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https://www.readbyqxmd.com/read/28484674/identification-of-demographic-factors-and-health-problems-that-affect-the-acceptance-of-disease-and-health-behaviors-of-patients-with-osteoarthritis
#1
Matylda Sierakowska, Izabela Wysocka-Skurska, Wojciech Kułak
INTRODUCTION: Osteoarthritis (OA) is one of the most common causes of musculoskeletal system's ailments. In the prevention of the disease and in its comprehensive treatment, proper health-related behavior becomes an extremely important factor for maintaining an optimal health condition. The aim of the study is to assess the relationship between the reported pain and the disability level, and the health-related behaviors undertaken by OA patients as well as their acceptance of the disease...
2017: PeerJ
https://www.readbyqxmd.com/read/28483418/mll3-and-mll4-facilitate-enhancer-rna-synthesis-and-transcription-from-promoters-independently-of-h3k4-monomethylation
#2
Kristel M Dorighi, Tomek Swigut, Telmo Henriques, Natarajan V Bhanu, Benjamin S Scruggs, Nataliya Nady, Christopher D Still, Benjamin A Garcia, Karen Adelman, Joanna Wysocka
Monomethylation of histone H3 at lysine 4 (H3K4me1) and acetylation of histone H3 at lysine 27 (H3K27ac) are correlated with transcriptionally engaged enhancer elements, but the functional impact of these modifications on enhancer activity is not well understood. Here we used CRISPR/Cas9 genome editing to separate catalytic activity-dependent and independent functions of Mll3 (Kmt2c) and Mll4 (Kmt2d, Mll2), the major enhancer H3K4 monomethyltransferases. Loss of H3K4me1 from enhancers in Mll3/4 catalytically deficient cells causes partial reduction of H3K27ac, but has surprisingly minor effects on transcription from either enhancers or promoters...
May 18, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28434841/transcriptional-dependencies-in-diffuse-intrinsic-pontine-glioma
#3
Surya Nagaraja, Nicholas A Vitanza, Pamelyn J Woo, Kathryn R Taylor, Fang Liu, Lei Zhang, Meng Li, Wei Meng, Anitha Ponnuswami, Wenchao Sun, Jie Ma, Esther Hulleman, Tomek Swigut, Joanna Wysocka, Yujie Tang, Michelle Monje
Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric cancer with limited therapeutic options. The majority of cases of DIPG exhibit a mutation in histone-3 (H3K27M) that results in oncogenic transcriptional aberrancies. We show here that DIPG is vulnerable to transcriptional disruption using bromodomain inhibition or CDK7 blockade. Targeting oncogenic transcription through either of these methods synergizes with HDAC inhibition, and DIPG cells resistant to HDAC inhibitor therapy retain sensitivity to CDK7 blockade...
May 8, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28386369/prognostic-role-of-lymphatic-vessel-density-and-lymphovascular-invasion-in-chemotherapy-naive-and-chemotherapy-treated-patients-with-invasive-breast-cancer
#4
Joanna A Niemiec, Agnieszka Adamczyk, Aleksandra Ambicka, Anna Mucha-Małecka, Wojciech M Wysocki, Beata Biesaga, Marek Ziobro, Ida Cedrych, Aleksandra Grela-Wojewoda, Małgorzata Domagała-Haduch, Joanna Wysocka, Janusz Ryś, Beata Sas-Korczyńska
It is assumed that the spread of breast cancer cells via the lymphatic system might be influenced by inflammatory reactions and/or the application of chemotherapy or molecularly targeted therapy. Therefore, we analysed survival according to lymphatic vessel density (LVD), lymphovascular invasion (LVI) (both assessed using podoplanin as immunohistochemical marker of lymphatic endothelium) and well-established clinico-pathological features in a group of 358 patients with invasive ductal breast cancer: 139 chemotherapy-naïve (pT1-2/pN0/M0) and 219 treated with chemotherapy (pT1-4/pN1-3/M0)...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28376720/dynamic-changes-of-paraoxonase-1-activity-towards-paroxon-and-phenyl-acetate-during-coronary-artery-surgery
#5
Anna Wysocka, Marek Cybulski, Henryk Berbeć, Andrzej Wysokiński, Janusz Stążka, Jadwiga Daniluk, Tomasz Zapolski
BACKGROUND: Serum paraoxonase 1 (PON1), an enzyme associated with high - density lipoproteins (HDL) particles, inhibits the oxidation of serum lipoproteins and cell membranes. PON1 activity is lower in patients with atherosclerosis and in inflammatory diseases. The systemic inflammatory response provoked during cardiopulmonary bypass grafting may contribute to the development of postoperative complications. The aim of the present study was to estimate the dynamic changes in paraoxonase 1 (PON1) activity towards paraoxon and phenyl acetate during and after coronary artery surgery...
April 4, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28367440/analysis-of-early-neurovascular-complications-of-pediatric-supracondylar-humerus-fractures-a-long-term-observation
#6
Ryszard Tomaszewski, Artur Wozowicz, Paulina Wysocka-Wojakiewicz
Purpose. Analysis of early vascular and nerve complications of supracondylar humerus fractures in children. Material and Methods. 220 children hospitalized in the Pediatric Trauma-Orthopedic Department in the years 2004-2014. The group consisted of 143 males and 77 females. Results. Acute neurovascular complications occurred in 16.81% of patients with displaced supracondylar fracture (37 children). Nerve damage was found in 10% of patients with displaced fracture (22 children). The most injured nerve was median nerve; this complication occurred in 15 patients (68...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28348501/an-investigation-into-the-relation-between-the-technique-of-movement-and-overload-in-step-aerobics
#7
Alicja Rutkowska-Kucharska, Katarzyna Wysocka, Sławomir Winiarski, Agnieszka Szpala, Małgorzata Sobera
The aim of this research was to determine the features of a step workout technique which may be related to motor system overloading in step aerobics. Subjects participating in the research were instructors (n = 15) and students (n = 15) without any prior experience in step aerobics. Kinematic and kinetic data was collected with the use of the BTS SMART system comprised of 6 calibrated video cameras and two Kistler force plates. The subjects' task was to perform basic steps. The following variables were analyzed: vertical, anteroposterior, and mediolateral ground reaction forces; foot flexion and abduction and adduction angles; knee joint flexion angle; and trunk flexion angle in the sagittal plane...
2017: Applied Bionics and Biomechanics
https://www.readbyqxmd.com/read/28339523/factors-affecting-the-quality-of-life-of-chronic-dialysis-patients
#8
Beata Jankowska-Polanska, Izabella Uchmanowicz, Agata Wysocka, Bartosz Uchmanowicz, Katarzyna Lomper, Andrzej M Fal
: Patients on hemodialysis must adjust their life plans to the treatment. They are aware of losing their health and independence. Therefore, acceptance of illness (AI) is important and allows the patient to adjust to new situation and alleviates negative emotions The aim of study was to assess the impact of AI and other socioclinical variables on hemodialysis patients' quality of life (QoL).The study included 100 patients aged 20-85 (M = 57), treated with hemodialysis for at least 2 years. Two validated instruments were used: the Acceptance of Illness Scale (AIS) and the World Health Organization Quality of Life questionnaire...
October 19, 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/28300214/corrigendum-hipstr-and-thousands-of-lncrnas-are-heterogeneously-expressed-in-human-embryos-primordial-germ-cells-and-stable-cell-lines
#9
Dinar Yunusov, Leticia Anderson, Lucas Ferreira DaSilva, Joanna Wysocka, Toshihiko Ezashi, R Michael Roberts, Sergio Verjovski-Almeida
No abstract text is available yet for this article.
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28255979/epidemiology-of-gastroenteropancreatic-neuroendocrine-neoplasms-in-krakow-and-krakow-district-in-2007-2011
#10
Małgorzata Trofimiuk-Müldner, Ewelina Lewkowicz, Katarzyna Wysocka, Dorota Pach, Agnieszka Kiełtyka, Agnieszka Stefańska, Anna Sowa-Staszczak, Romana Tomaszewska, Alicja Hubalewska-Dydejczyk
INTRODUCTION: Gastroenteropancreatic neuroendocrine neoplasms (GEPNEN) are rare and heterogeneous tumours with variable biology. The aim of this study was to evaluate the epidemiology of GEPNEN in the population of Krakow and Krakow district in 2007-2011. MATERIAL AND METHODS: The Database of the Chair and Department of Endocrinology, Jagiellonian University Medical College, comprising the data on NEN cases collected from the Endocrinology Department, University Hospital in Krakow and from independent sources: surgery, pathology, and endocrinology departments located in the Krakow area, was searched for cases of GEPNEN patients living in Krakow and Krakow district, diagnosed between 2007 and 2011...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28235699/long-term-changes-in-the-concentration-of-radium-in-discharge-waters-of-coal-mines-and-upper-silesian-rivers
#11
Stanisław Chałupnik, Małgorzata Wysocka, Ewa Janson, Izabela Chmielewska, Marta Wiesner
According to the latest guidelines of the International Atomic Energy Agency (IAEA, 2016), coal mining is one of the most important contributors to occupational exposure. Coal mining contributes about 45% of the total annual collective dose obtained by workers due to the exposure at places of working. One of the sources of exposure in mining are formation brines with elevated concentrations of natural radionuclides, the most common are radium (226)Ra and (228)Ra. Radium isotopes often occur in formation waters in underground collieries in the Upper Silesian region (USCB) in Poland...
May 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28182108/assessment-of-the-usefulness-of-multiplex-real-time-pcr-tests-in-the-diagnostic-and-therapeutic-process-of-pneumonia-in-hospitalized-children-a-single-center-experience
#12
Ewelina Gowin, Alicja Bartkowska-Śniatkowska, Katarzyna Jończyk-Potoczna, Joanna Wysocka-Leszczyńska, Waldemar Bobkowski, Piotr Fichna, Paulina Sobkowiak, Katarzyna Mazur-Melewska, Anna Bręborowicz, Jacek Wysocki, Danuta Januszkiewicz-Lewandowska
The aim of the study was assessment of the usefulness of multiplex real-time PCR tests in the diagnostic and therapeutic process in children hospitalized due to pneumonia and burdened with comorbidities. Methods. The study group included 97 children hospitalized due to pneumonia at the Karol Jonscher Teaching Hospital in Poznań, in whom multiplex real-time PCR tests (FTD respiratory pathogens 33; fast-track diagnostics) were used. Results. Positive test results of the test were achieved in 74 patients (76...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28181910/clinical-usefulness-of-serum-free-light-chains-measurement-in-patients-with-multiple-myeloma-comparative-analysis-of-two-different-tests
#13
Tadeusz Kubicki, Dominik Dytfeld, Aleksandra Baszczuk, Ewa Wysocka, Mieczysław Komarnicki, Krzysztof Lewandowski
INTRODUCTION: There are two commercially available tests for measurement of serum free light chains (sFLC) in multiple myeloma (MM) patients - Freelite and N Latex FLC. The aim of this study was to perform an assessment and direct comparison of the usefulness of the methods in routine clinical practice. METHODS: 40 refractory/relapsed MM patients underwent routine disease activity assessment studies, along with sFLC analysis using both assays. Correlation and concordance between the tests and sensitivity of studied methods of sFLC assessment were established...
January 4, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28114900/the-reverse-remodeling-of-the-aorta-in-patients-after-renal-transplantation-the-value-of-aortic-stiffness-index-prospective-echocardiographic-study
#14
Tomasz Zapolski, Jacek Furmaga, Andrzej Jaroszyński, Anna Wysocka, Sławomir Rudzki, Andrzej P Wysokiński
BACKGROUND: Atherosclerosis is regarded as a combination of two major separate diseases: atherosis and sclerosis. Sclerotic component depends on deterioration of elastic properties of the aortic wall and is called aortic stiffness. The most valuable, non-invasive method of aortic stiffness assessment is echocardiography, which allows to calculate the aortic stiffness index (ASI). ASI is an independent predictor of all-cause and cardiovascular mortality in different groups of patients...
January 23, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28075427/evaluation-of-sudomotor-function-in-adult-patients-with-long%C3%A2-lasting-type-1-diabetes
#15
Agnieszka Gandecka, Aleksandra Araszkiewicz, Stanisław Piłaciński, Bogna Wierusz-Wysocka, Dorota Zozulińska-Ziółkiewicz
INTRODUCTION The function of the sweat glands appears to be impaired in patients with diabetic complications. OBJECTIVES The aim of the study was to evaluate sudomotor function in adult patients with type 1 diabetes (DM1) and healthy controls and its relationship with metabolic control and diabetic complications. PATIENTS AND METHODS The study group included 404 patients with DM1 (194 women), aged 41 years (interquartile range [IQR], 32-51 years) and with disease duration of 23 years (IQR, 18-31 years). The control group included 84 healthy volunteers...
January 10, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/27932870/evaluation-of-quality-of-life-in-chronic-progressing-rheumatic-diseases-based-on-the-example-of-osteoarthritis-and-rheumatoid-arthritis
#16
Izabela Wysocka-Skurska, Matylda Sierakowska, Wojciech Kułak
BACKGROUND: Rheumatic diseases, irrespective of etiology and clinical course, influence different areas of a patient's life. Adapting to disability and limitations caused by an illness is very difficult for many patients. The main goal of a therapeutic procedure should be improvement of health-related quality of life (QoL). OBJECTIVE: Evaluation of the factors that influence the QoL that are conditioned by the state of health of patients with osteoarthritis (OA) and rheumatoid arthritis (RA)...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27930568/does-vaccination-ensure-protection-assessing-diphtheria-and-tetanus-antibody-levels-in-a-population-of-healthy-children-a-cross-sectional-study
#17
Ewelina Gowin, Jacek Wysocki, Ewelina Kałużna, Bogna Świątek-Kościelna, Joanna Wysocka-Leszczyńska, Michał Michalak, Danuta Januszkiewicz-Lewandowska
Vaccination effectiveness is proven when the disease does not develop after a patient is exposed to the pathogen. In the case of rare diseases, vaccination effectiveness is assessed by monitoring specific antibody levels in the population. Such recurrent analyses allow the evaluation of vaccination programs. The primary schedule of diphtheria and tetanus vaccinations is similar in various countries, with differences mainly in the number and timing of booster doses. The aim of the study was to assess diphtheria and tetanus antibody concentrations in a population of healthy children...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27906877/association-between-small-fiber-neuropathy-and-higher-skin-accumulation-of-advanced-glycation-end-products-in-patients-with-type-1-diabetes
#18
Aleksandra Araszkiewicz, Agnieszka Gandecka, Michał Nowicki, Aleksandra Uruska, Agnieszka Malińska, Katarzyna Kowalska, Bogna Wierusz-Wysocka, Dorota Zozulińska-Ziółkiewicz
INTRODUCTION Advanced glycation end products (AGEs) play a crucial role in the pathogenesis of diabetic peripheral neuropathy (DPN). OBJECTIVES The aim of the study was to assess the skin accumulation of AGEs in patients with long‑lasting type 1 diabetes in relation to the presence of DPN. PATIENTS AND METHODS We evaluated 178 patients with type 1 diabetes (99 men; age, 43 years [interquartile range [IQR], 34-54 years]; disease duration, 25 years [IQR, 18-31 years]). DPN was diagnosed if 2 or more of the following 5 abnormalities were present: symptoms of neuropathy, lack of ankle reflexes, and impaired sensation of touch, temperature, and/or vibration...
November 22, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27863239/ever-changing-landscapes-transcriptional-enhancers-in-development-and-evolution
#19
REVIEW
Hannah K Long, Sara L Prescott, Joanna Wysocka
A class of cis-regulatory elements, called enhancers, play a central role in orchestrating spatiotemporally precise gene-expression programs during development. Consequently, divergence in enhancer sequence and activity is thought to be an important mediator of inter- and intra-species phenotypic variation. Here, we give an overview of emerging principles of enhancer function, current models of enhancer architecture, genomic substrates from which enhancers emerge during evolution, and the influence of three-dimensional genome organization on long-range gene regulation...
November 17, 2016: Cell
https://www.readbyqxmd.com/read/27768595/is-senescence-associated-%C3%AE-galactosidase-a-marker-of-neuronal-senescence
#20
Malgorzata Piechota, Piotr Sunderland, Adrianna Wysocka, Maria Nalberczak, Malgorzata A Sliwinska, Kasia Radwanska, Ewa Sikora
One of the features of cellular senescence is the activity of senescence-associated- β-galactosidase (SA-β-gal). The main purpose of this study was to evaluate this marker of senescence in aging neurons. We found that cortical neurons exhibited noticeable SA-β-gal activity quite early in culture. Many SA-β-gal-positive neurons were negative for another canonical marker of senescence, namely, double-strand DNA breaks (DSBs). Moreover, DDR signalling triggered by low doses of doxorubicin did not accelerate the appearance of neuronal SA-β-gal...
December 6, 2016: Oncotarget
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