keyword
https://read.qxmd.com/read/38394684/epidemiology-studies-on-effects-of-lithium-salts-in-pregnancy-are-confounded-by-the-inability-to-control-for-other-potentially-teratogenic-factors
#21
JOURNAL ARTICLE
Carr J Smith, Victoria M Payne
INTRODUCTION: In bipolar women who took lithium during pregnancy, several epidemiology studies have reported small increases in a rare fetal cardiac defect termed Ebstein's anomaly. METHODS: Behavioral, environmental, and lifestyle-associated risk factors associated with bipolar disorder and health insurance status were determined from an Internet search. The search was conducted from October 1, 2023, through October 14, 2023. The search terms employed included the following: bipolar, bipolar disorder, mood disorders, pregnancy, congenital heart defects, Ebstein's anomaly, diabetes, hypertension, Medicaid, Medicaid patients, alcohol use, cigarette smoking, marijuana, cocaine, methamphetamine, narcotics, nutrition, diet, obesity, body mass index, environment, environmental exposures, poverty, socioeconomic status, divorce, unemployment, and income...
2024: Human & Experimental Toxicology
https://read.qxmd.com/read/38389989/hypothyroidism-and-sinus-dysfunction-associated-with-lithium-paliperidone-combination-therapy-for-bipolar-disorder-with-psychotic-symptoms-a-case-report
#22
Wenjian Wei, Yonglan Yang, Haifeng Wang, Yunbin Yang, Jizhou Liu, Jinfeng Li
BACKGROUND AND AIM: Lithium is considered to be the first-line treatment for bipolar disorder, and paliperidone was approved for the treatment of schizophrenia and acute bipolar manic/mixed episodes. However, both agents have been associated with thyroid dysfunction and cardiovascular adverse effects like subclinical hypothyroidism, bradycardia, and sinus arrest, even at therapeutic doses. CASE PRESENTATION: Here, we reported a case of a 17-year-old Han Chinese female who developed symptomatic hypothyroidism, sinus bradycardia, and sinus arrest while being treated with lithium and paliperidone for bipolar disorder with psychotic features including auditory hallucinations...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38386042/doxycycline-reversal-of-amphetamine-induced-mania-like-behavior-is-related-to-adjusting-brain-monoamine-abnormalities-and-antioxidant-effects-in-primary-hippocampal-neurons
#23
JOURNAL ARTICLE
Adriano José Maia Chaves-Filho, Michele Verde-Ramo Soares, Paloma Marinho Jucá, Tatiana de Queiroz Oliveira, Dino Cesar da Silva Clemente, Carlos Eduardo da Silva Monteiro, Francisca Géssica Oliveira Silva, Pedro Everson Alexandre de Aquino, Danielle S Macedo
Mania is associated with disturbed dopaminergic transmission in frontotemporal regions. D-amphetamine (AMPH) causes increased extracellular DA levels, considered an acknowledged mania model in rodents. Doxycycline (DOXY) is a second-generation tetracycline with promising neuroprotective properties. Here, we tested the hypothesis that DOXY alone or combined with Lithium (Li) could reverse AMPH-induced mania-like behavioral alterations in mice by the modulation of monoamine levels in brain areas related to mood regulation, as well as cytoprotective and antioxidant effects in hippocampal neurons...
February 22, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38382831/magnesium-lithium-thin-films-for-neurological-applications-an-in-vitro-investigation-of-glial-cytocompatibility-and-neuroinflammatory-response
#24
JOURNAL ARTICLE
Krathika Bhat, Luise Schlotterose, Lisa Hanke, Heike Helmholz, Eckhard Quandt, Kirsten Hattermann, Regine Willumeit-Römer
Lithium (Li), a widely used drug for bipolar disorder management, is associated with many side effects due to systemic exposure. The localized delivery of lithium through implants could be an approach to overcome this challenge, for which biodegradable magnesium (Mg)-based materials are a promising choice. In this study, we focus on Mg-Li thin film alloys as potential Li-releasing implants. Therefore, we investigated the in vitro short-term corrosion behavior and cytocompatibility of two alloys, Mg-1.6wt%Li and Mg-9...
February 19, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38381901/prospective-comparative-pilot-study-of-maintenance-treatment-in-comorbid-bipolar-disorders-with-post-traumatic-stress-disorder
#25
JOURNAL ARTICLE
Hernán F Guillen-Burgos, Juan F Gálvez-Flórez, Sergio Moreno-Lopez, Angela T H Kwan, Roger S McIntyre
There is limited real-world evidence that evaluates the impact of monotherapy vs. combination therapy as a maintenance treatment in comorbid post-traumatic stress disorder (PTSD) in bipolar disorder (BD). Our aim was to compare lithium vs. lithium plus quetiapine in maintenance treatment in a sample of comorbid BD with PTSD. An exploratory, comparative pilot study over a 28-week period in 34 comorbid BD with PTSD patients was performed to compare monotherapy (n = 18) vs. combination therapy (n = 16) during maintenance treatment...
February 22, 2024: International Clinical Psychopharmacology
https://read.qxmd.com/read/38374833/chronic-lithium-intoxication-a-challenging-diagnosis
#26
Sofia Ferreira, Sara Santos, Sérgio Gomes Ferreira, Luís Fernandes, Penélope Almeida
Lithium has been used in clinical practice since the 1970s. This medication is commonly used to treat and prevent bipolar disorder, but it has a narrow therapeutic index, making toxicity a frequent occurrence. Chronic lithium intoxication can arise due to progressive accumulation, particularly in contexts of dehydration. The effects of chronic lithium intoxication on the nervous, renal, and cardiac systems, as well as on the thyroid and parathyroid glands, are well documented in the literature. The authors present the case of a 66-year-old woman with schizoaffective psychosis and chronic kidney disease, admitted due to altered mental status and dysarthria...
January 2024: Curēus
https://read.qxmd.com/read/38352640/sinus-node-dysfunction-and-pulmonary-hypertension-double-trouble-with-lithium-therapy
#27
Shweta Vohra, Akshyaya Pradhan, Rishi Sethi, Monika Bhandari
Lithium is considered a gold standard drug for the management of bipolar disorder and is a widely used mood-stabilizing drug in psychiatry practice. However, its side effects are of important concern. The narrow therapeutic index of lithium predispose to its toxicity/side effects, but various case reports and research has shown that adverse drug reactions can occur even in the therapeutic range. We present the case of a 56-year-old woman with no history of cardiac illness presenting with tachycardia-bradycardia syndrome along with moderate pulmonary hypertension...
February 2024: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://read.qxmd.com/read/38321324/syndrome-of-irreversible-lithium-effectuated-neurotoxicity-silent-a-preventable-cerebellar-disorder
#28
JOURNAL ARTICLE
Sarah Marmol, Nestor Beltre, Jason Margolesky
We report a case study of a 60-year-old man with bipolar disorder on stable lithium treatment who developed severe toxicity while admitted to ICU with sepsis and multiorgan failure. Despite unchanged lithium administration, his serum levels escalated due to renal dysfunction, resulting in lithium toxicity. After regaining consciousness, he exhibited a cerebellar syndrome marked by ataxia, tremor, and scanning speech. MRI revealed cerebellar atrophy. Following discontinuation of lithium and hemodialysis, the patient's symptoms remained static...
February 7, 2024: Cerebellum
https://read.qxmd.com/read/38310671/should-lithium-be-used-in-children-and-adolescents-with-bipolar-disorder
#29
JOURNAL ARTICLE
Gonzalo Salazar de Pablo, Allan H Young
No abstract text is available yet for this article.
February 3, 2024: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/38306997/cell-type-deconvolution-of-bulk-blood-rna-seq-reveals-biological-insights-into-neuropsychiatric-disorders
#30
JOURNAL ARTICLE
Toni Boltz, Tommer Schwarz, Merel Bot, Kangcheng Hou, Christa Caggiano, Sandra Lapinska, Chenda Duan, Marco P Boks, Rene S Kahn, Noah Zaitlen, Bogdan Pasaniuc, Roel Ophoff
Genome-wide association studies (GWASs) have uncovered susceptibility loci associated with psychiatric disorders such as bipolar disorder (BP) and schizophrenia (SCZ). However, most of these loci are in non-coding regions of the genome, and the causal mechanisms of the link between genetic variation and disease risk is unknown. Expression quantitative trait locus (eQTL) analysis of bulk tissue is a common approach used for deciphering underlying mechanisms, although this can obscure cell-type-specific signals and thus mask trait-relevant mechanisms...
February 1, 2024: American Journal of Human Genetics
https://read.qxmd.com/read/38291410/chronic-kidney-disease-incidences-in-thai-outpatients-diagnosed-with-psychiatric-illnesses-receiving-lithium-maintenance-therapy-a-university-hospital-based-study
#31
JOURNAL ARTICLE
Jarurin Pitanupong, Chavisa Jittpratoom, Kanthee Anantapong
BACKGROUND: There has been no previous study in Thailand regarding the incidence of lithium-induced abnormal renal function. Hence, this study aimed to assess the effect of lithium maintenance therapy on chronic kidney disease, and associated factors among outpatients diagnosed with a psychiatric illness within Southern Thailand. METHODS: This was a retrospective study, using an information review from the electronic medical records of Songklanagarind Hospital computer system in the last ten years; from 1 January 2013 until 31 September 2022...
January 30, 2024: BMC Psychiatry
https://read.qxmd.com/read/38290587/areas-of-interest-and-sentiment-analysis-towards-second-generation-antipsychotics-lithium-and-mood-stabilizing-anticonvulsants-unsupervised-analysis-using-twitter
#32
JOURNAL ARTICLE
J P Chart-Pascual, M Montero-Torres, Miguel Angel Ortega, L Mar-Barrutia, I Zorrilla, Melchor Alvarez-Mon, A Gonzalez-Pinto, Miguel Angel Alvarez-Mon
BACKGROUND: Severe mental disorders like Schizophrenia and related psychotic disorders (SRD) or Bipolar Disorder (BD) require pharmacological treatment for relapse prevention and quality of life improvement. Yet, treatment adherence is a challenge, partly due to patients' attitudes and beliefs towards their medication. Social media listening offers insights into patient experiences and preferences, particularly in severe mental disorders. METHODS: All tweets posted between 2008 and 2022 mentioning the names of the main drugs used in SRD and BD were analyzed using advanced artificial intelligence techniques such as machine learning (ML) and deep learning (DL), along with natural language processing (NLP), RESULTS: In this 15-year study analyzing 893,289 tweets, second generation antipsychotics received more mentions in English tweets, whereas mood stabilizers received more tweets in Spanish...
January 28, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38289730/chronic-lithium-toxicity-in-old-age-patients-taking-angiotensin-receptor-blocker-a-case-report
#33
JOURNAL ARTICLE
Asim Pandey, Kunjan Khanal, Anushree Jha, Prava Basnet, Dipesh Bhattarai
UNLABELLED: Chronic lithium toxicity is a potentially serious side effect on patients taking lithium for a prolonged period with the diagnosis of mood disorders. The toxicity is even higher in patients taking drugs that interfere with the metabolism of lithium like angiotensin receptor blockers and in older patients with reduced kidney function. In this report, we present the case of a 62-year-old woman who presented to the emergency department with symptoms including loose stools, generalised body weakness, slurred speech, coarse hand tremors, and dystonia persisting for fifteen days...
November 1, 2023: JNMA; Journal of the Nepal Medical Association
https://read.qxmd.com/read/38280568/a-pilot-study-examining-the-impact-of-lithium-treatment-and-responsiveness-on-mnemonic-discrimination-in-bipolar-disorder
#34
JOURNAL ARTICLE
Dhanyaasri Madanlal, Christian Guinard, Vanessa Pardo Nuñez, Suzanna Becker, Julie Garnham, Anouar Khayachi, Simon Léger, Claire O'Donovan, Selena Singh, Shani Stern, Claire Slaney, Thomas Trappenberg, Martin Alda, Abraham Nunes
INTRODUCTION: Mnemonic discrimination (MD), the ability to discriminate new stimuli from similar memories, putatively involves dentate gyrus pattern separation. Since lithium may normalize dentate gyrus functioning in lithium-responsive bipolar disorder (BD), we hypothesized that lithium treatment would be associated with better MD in lithium-responsive BD patients. METHODS: BD patients (N = 69; NResponders  = 16 [23 %]) performed the Continuous Visual Memory Test (CVMT), which requires discriminating between novel and previously seen images...
January 25, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38275522/international-trends-in-lithium-use-for-pharmacotherapy-and-clinical-correlates-in-bipolar-disorder-a-scoping-review
#35
REVIEW
Yao Kang Shuy, Sanjana Santharan, Qian Hui Chew, Kang Sim
Lithium remains an effective option in the treatment of bipolar disorder (BD). Thus, we aim to characterize the pharmaco-epidemiological patterns of lithium use internationally over time and elucidate clinical correlates associated with BD using a scoping review, which was conducted using the methodological framework by Arksey and O'Malley (2005). We searched several databases for studies that examined the prescriptions for lithium and clinical associations in BD from inception until December 2023. This review included 55 articles from 1967 to 2023, which collected data from North America ( n = 24, 43...
January 20, 2024: Brain Sciences
https://read.qxmd.com/read/38266158/ferrocene-appended-porphyrin-based-bipolar-electrode-material-for-high-performance-energy-storage
#36
JOURNAL ARTICLE
Shagor Chowdhury, Saibal Jana, Sai Panguluri, Wolfgang Wenzel, Svetlana Klayatskaya, Mario Ruben, Sai P K Panguluri
The versatile properties of bipolar organic electrode materials have attracted considerable attention in the field of electrochemical energy storage (EES). However, their practical application is hindered by their inherent limitations including low intrinsic electrical conductivity, low specific capacity, and high solubility. Herein, a bipolar organic molecule combining both porphyrin and ferrocene moieties (CuDEFcP) [5,15-bis(ethynyl)-10,20-di ferrocenyl porphinato]copper(II)) has been developed. It is proposed as a new organic electrode material with multifunctional application for rechargeable organic lithium-based batteries (ROLBs) and dual-ion organic symmetric batteries (SDIBs)...
January 24, 2024: ChemSusChem
https://read.qxmd.com/read/38253983/valproate-induced-hyperammonemia-neuroleptic-sensitivity-and-cerebellar-atrophy-a-clinical-conundrum-in-the-management-of-bipolar-disorder
#37
JOURNAL ARTICLE
Samarth S Shetty, Harshitha H AnnajiGowda, Ajit Bhalchandra Dahale
OBJECTIVE: Treatment of bipolar disorder (BD) involves complexities especially when patients come with significant sensitivity to various psychotropic medications and comorbidities. The following cases aim to recapitulate and discuss some of such situations. CASES: Case 1: A 36-year-old man with intellectual development disorder and BD experienced catatonia, seizures, and hyperammonemia following valproate administration. Treatment involved electroconvulsive therapy (ECT) and a tailored medication regimen, ultimately leading to stability...
January 22, 2024: Bipolar Disorders
https://read.qxmd.com/read/38253804/marked-alteration-of-phosphoinositide-signaling-associated-molecules-in-postmortem-prefrontal-cortex-with-bipolar-disorder
#38
JOURNAL ARTICLE
Mizuki Hino, Yasuto Kunii, Risa Shishido, Atsuko Nagaoka, Junya Matsumoto, Hiroyasu Akatsu, Yoshio Hashizume, Hideki Hayashi, Akiyoshi Kakita, Hiroaki Tomita, Hirooki Yabe
AIM: The etiology of bipolar disorder (BD) remains unknown; however, lipid abnormalities in BD have received increasing attention in recent years. In this study, we examined the expression levels of enzyme proteins associated with the metabolic pathway of phosphoinositides (PIs) and their downstream effectors, protein kinase B (Akt1) and glycogen synthase kinase 3β (GSK3β), which have been assumed to be the targets of mood stabilizers such as lithium, in the postmortem brains of patients with BD...
January 22, 2024: Neuropsychopharmacology Reports
https://read.qxmd.com/read/38248232/what-came-first-mania-or-depression-polarity-at-onset-in-bipolar-i-and-ii-temperament-and-clinical-course
#39
JOURNAL ARTICLE
Delfina Janiri, Alessio Simonetti, Lorenzo Moccia, Daniele Hirsch, Silvia Montanari, Marianna Mazza, Marco Di Nicola, Georgios D Kotzalidis, Gabriele Sani
(1) Background: Bipolar disorder (BD) is divided into type I (BD-I) and type II (BD-II). Polarity at onset (PO) is a proposal to specify the clinical course of BD, based on the type of the first episode at disorder onset-depressive (D-PO) or manic (M-PO). At the same time, affective temperaments represent preexisting variants of the spectrum of affective disorders. Our objectives were to investigate the hypothesis that temperament may exert an influence on PO, and that this factor can serve as an indicator of the forthcoming course of the disorder, carrying significant therapeutic implications...
December 23, 2023: Brain Sciences
https://read.qxmd.com/read/38240178/lithium-use-and-bone-health-in-women-with-bipolar-disorder-a-cross-sectional-study
#40
JOURNAL ARTICLE
Lana J Williams, Bruno Agustini, Amanda L Stuart, Julie A Pasco, Jason M Hodge, Rasika M Samarasinghe, Ottar Bjerkeset, Shae E Quirk, Heli Koivumaa-Honkanen, Risto Honkanen, Jeremi Heikkinen, Michael Berk
INTRODUCTION: Several psychiatric disorders and medications used to treat them appear to be independently associated with skeletal deficits. As there is increasing evidence that lithium possesses skeletal protective properties, we aimed to investigate the association between lithium use and bone health in a group of women with bipolar disorder. METHOD: Women with bipolar disorder (n = 117, 20+ years) were recruited from south-eastern Australia...
January 19, 2024: Acta Psychiatrica Scandinavica
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