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https://www.readbyqxmd.com/read/28076953/effects-of-lithium-and-other-monovalent-ions-on-palmitoyl-oleoyl-phosphatidylcholine-bilayer
#1
James Kruczek, See-Wing Chiu, Eric Jakobsson, Sagar A Pandit
Interations of monovalent salts with lipid membranes are explored with Molecular Dynamic (MD) simulations. The simulations included the monovalent ions Na(+) and K(+), for their importance in physiology, Li(+) for its small size and importance in several medical conditions including bipolar disorder, and Rb(+) for its large size. All the simulations included Cl(-) as counter ions. One bilayer was simulated without salt as a control. POPC bilayers experienced reductions in area per lipid with the addition of salt, the smaller the ion the smaller the area, with the exception of Li(+)...
January 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28068832/book-review-finding-sanity-john-cade-lithium-and-the-taming-of-bipolar-disorder-de-moore-greg-westmore-ann-allen-and-unwin-sydney
#2
Richard T White
No abstract text is available yet for this article.
January 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28066149/neuroprotective-effect-of-lithium-after-pilocarpine-induced-status-epilepticus-in-mice
#3
Namgue Hong, Yun-Sik Choi, Seong Yun Kim, Hee Jung Kim
Status epilepticus is the most common serious neurological condition triggered by abnormal electrical activity, leading to severe and widespread cell loss in the brain. Lithium has been one of the main drugs used for the treatment of bipolar disorder for decades, and its anticonvulsant and neuroprotective properties have been described in several neurological disease models. However, the therapeutic mechanisms underlying lithium's actions remain poorly understood. The muscarinic receptor agonist pilocarpine is used to induce status epilepticus, which is followed by hippocampal damage...
January 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28064463/global-research-trends-in-lithium-toxicity-from-1913-to-2015-a-bibliometric-analysis
#4
Sa'ed H Zyoud, W Stephen Waring, Waleed M Sweileh, Samah W Al-Jabi
Lithium salts have been used to treat psychiatric disorders since the 1940s and are currently used in prophylaxis and treatment of depression and bipolar disorder. Therefore, we conducted this study to assess lithium toxicity-related publications using bibliometric approaches from a health point of view to assess global research trends in the lithium toxicity field to offer guidance to future research in this field. The data were retrieved from the online version of Scopus database on 6 August 2016. All records with the term "lithium" in the title were retrieved, and those related to lithium toxicity were evaluated...
January 8, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28063207/lithiumeter-version-2-0
#5
Gin S Malhi, Samuel Gershon, Tim Outhred
BACKGROUND: The Lithiumeter was developed as a visual and practical guide for determining lithium levels in the management of bipolar disorder (BD). It appears to have been well received, as evidenced by its increasing popularity amongst doctors as a deskside clinical aide, and adoption and reproduction of the schematic in clinical guidelines and texts. However, since its publication 5 years ago, key basic neuroscience and clinical research developments pertaining to lithium have significantly advanced our understanding, necessitating further refinement of guidance concerning the practicalities of lithium therapy...
December 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/28054457/doping-control-analysis-of-lithium-in-horse-urine-and-plasma-by-inductively-coupled-plasma-mass-spectrometry
#6
Timmy L S Choi, Jenny K Y Wong, Emmie N M Ho, Wai Him Kwok, Gary N W Leung, Peter Curl, Terence S M Wan
Lithium salts are commonly prescribed to treat bipolar disorder in humans. They are effective for the treatment of acute mania and the prophylaxis of manic relapses through long-term use. Although there is no reported legitimate therapeutic use of lithium in horses, its potential mood stabilizing effect, low cost and being readily available make lithium salt a potential agent of abuse in equine sports, especially for equestrian competition horses. Lithium can be found in soil, plants and water, as such it is naturally present in the equine body, thus a threshold is necessary to control its misuse in horses...
January 5, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28044944/a-pragmatic-approach-to-the-diagnosis-and-treatment-of-mixed-features-in-adults-with-mood-disorders
#7
Roger S McIntyre, Yena Lee, Rodrigo B Mansur
Mixed features specifier (MFS) is a new nosological entity defined and operationalized in the Diagnostic and Statistical Manual of Mental Disorders (DSM), 5th Edition. The impetus to introduce the MFS and supplant mixed states was protean, including the lack of ecological validity, high rates of misdiagnosis, and guideline discordant treatment for mixed states. Mixed features specifier identifies a phenotype in psychiatry with greater illness burden, as evidenced by earlier age at onset, higher episode frequency and chronicity, psychiatric and medical comorbidity, suicidality, and suboptimal response to conventional antidepressants...
December 2016: CNS Spectrums
https://www.readbyqxmd.com/read/28040641/psychopharmacological-drug-utilization-patterns-in-pregnant-women-with-bipolar-disorder-a-nationwide-register-based-study
#8
S C Broeks, H Thisted Horsdal, K Glejsted Ingstrup, C Gasse
BACKGROUND: Bipolar disorder is often associated with a lifetime indication for treatment with psychotropic drugs, thus pregnant women face the dilemma whether to continue treatment or not. This study describes the psychopharmacological drug utilization patterns among women with bipolar disorder from 12 months preconception to 12 months postpartum. METHODS: We conducted a register-based cohort study among all Danish women aged 15-55 with a diagnosis of bipolar disorder, who gave birth to their first and singleton child between January 1997 and December 2012...
December 8, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28035180/bipolar-disorder-associated-microrna-mir-1908-5p-regulates-the-expression-of-genes-functioning-in-neuronal-glutamatergic-synapses
#9
Yoonhee Kim, Yinhua Zhang, Kaifang Pang, Hyojin Kang, Heejoo Park, Yeunkum Lee, Bokyoung Lee, Heon-Jeong Lee, Won-Ki Kim, Dongho Geum, Kihoon Han
Bipolar disorder (BD), characterized by recurrent mood swings between depression and mania, is a highly heritable and devastating mental illness with poorly defined pathophysiology. Recent genome-wide molecular genetic studies have identified several protein-coding genes and microRNAs (miRNAs) significantly associated with BD. Notably, some of the proteins expressed from BD-associated genes function in neuronal synapses, suggesting that abnormalities in synaptic function could be one of the key pathogenic mechanisms of BD...
December 2016: Experimental Neurobiology
https://www.readbyqxmd.com/read/28004626/treating-mixed-mania-hypomania-a-review-and-synthesis-of-the-evidence
#10
Minoru Takeshima
The DSM-5 incorporates a broad concept of mixed states and captured ≥3 nonoverlapping symptoms of the opposite polarity using a "with mixed features" specifier to be applied to manic/hypomanic and major depressive episodes. Pharmacotherapy of mixed states is challenging because of the necessity to treat both manic/hypomanic and depressive symptoms concurrently. High-potency antipsychotics used to treat manic symptoms and antidepressants can potentially deteriorate symptoms of the opposite polarity. This review aimed to provide a synthesis of the current evidence for pharmacotherapy of mixed states with an emphasis on mixed mania/hypomania...
December 22, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/28002662/association-between-lithium-use-and-risk-of-alzheimer-s-disease
#11
Chin Cheng, Peter Zandi, Elizabeth Stuart, Ching-Heng Lin, Pei-Yu Su, G Caleb Alexander, Tsuo-Hung Lan
OBJECTIVE: Current evidence for the association between use of lithium and risk of dementia is mixed. The objective of this study was to assess the risk of Alzheimer's disease associated with use of lithium. METHODS: A population-based, nested case-control study was conducted using data from the National Health Insurance Research Database in 2002 covering 24.5 million beneficiaries of the Taiwan National Health Insurance Program from January 1, 1997, to December 31, 2009...
December 20, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27999548/low-dose-lithium-stabilizes-human-endothelial-barrier-by-decreasing-mlc-phosphorylation-and-universally-augments-cholinergic-vasorelaxation-capacity-in-a-direct-manner
#12
Bert Bosche, Marek Molcanyi, Soham Rej, Thorsten R Doeppner, Mark Obermann, Daniel J Müller, Anupam Das, Jürgen Hescheler, R Loch Macdonald, Thomas Noll, Frauke V Härtel
Lithium at serum concentrations up to 1 mmol/L has been used in patients suffering from bipolar disorder for decades and has recently been shown to reduce the risk for ischemic stroke in these patients. The risk for stroke and thromboembolism depend not only on cerebral but also on general endothelial function and health; the entire endothelium as an organ is therefore pathophysiologically relevant. Regardless, the knowledge about the direct impact of lithium on endothelial function remains poor. We conducted an experimental study using lithium as pharmacologic pretreatment for murine, porcine and human vascular endothelium...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27996307/clock-genes-associate-with-white-matter-integrity-in-depressed-bipolar-patients
#13
Irene Bollettini, Elisa Maria Teresa Melloni, Veronica Aggio, Sara Poletti, Cristina Lorenzi, Adele Pirovano, Benedetta Vai, Sara Dallaspezia, Cristina Colombo, Francesco Benedetti
Human genetic studies have implicated specific genes that constitute the molecular clock in the manifestation of bipolar disorder (BD). Among the clock genes involved in the control system of circadian rhythms, CLOCK 3111 T/C and Period3 (PER3) influence core psychopathological features of mood disorders, such as patterns of sleep, rest, and activity, diurnal preference, cognitive performances after sleep loss, age at the onset of the illness, and response to antidepressant treatment. Furthermore, several studies pointed out that bipolar symptomatology is associated with dysfunctions in white matter (WM) integrity, suggesting these structural alterations as a possible biomarker of the disorder...
December 20, 2016: Chronobiology International
https://www.readbyqxmd.com/read/27992666/lithium-toxicity-in-a-pregnant-woman
#14
Nasim Zamani, Maryam Paeezi, Hossein Hassanian-Moghaddam
Lithium is recommended in bipolar disorder and can be accompanied by significant toxicity in pregnant women. A 25-year-old single-gestation pregnant woman (28 weeks) was referred with suspicion of lithium toxicity. Serum lithium was 2.1 meq/L. Despite conservative therapy with intravenous fluids, lithium concentration increased to 5.0 meq/L 6 hr post admission mandating an emergent hemodialysis during which foetal heart rate decreased to 90 bpm. The gynaecologist ordered termination of pregnancy while the mother was still on hemodialysis...
December 19, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27987204/childhood-trauma-and-mixed-episodes-are-associated-with-poor-response-to-lithium-in-bipolar-disorders
#15
B Etain, M Lajnef, C Brichant-Petitjean, P A Geoffroy, C Henry, S Gard, J P Kahn, M Leboyer, A H Young, F Bellivier
OBJECTIVES: Reliable predictors of response to lithium are still lacking in bipolar disorders (BDs). However, childhood trauma has been hypothesized to be associated with poor response to lithium. METHODS: We included 148 patients with BD, euthymic when retrospectively and clinically assessed for response to lithium and childhood trauma using reliable scales. RESULTS: According to the 'Alda scale', the sample consisted in 20.3% of excellent responders, 49...
December 16, 2016: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/27974284/decreased-responsiveness-following-lithium-discontinuation-in-bipolar-disorder-a-naturalistic-observation-study
#16
Sibel Cakir, Olcay Yazıcı, Robert M Post
Lithium is a cornerstone in treatment of bipolar disorder. Findings are conflicting as to whether acquired unresponsiveness occurs following the discontinuation. Retrospective life chart data were evaluated to investigate the incidence of loss of response. Sixty-five patients chosen from a larger cohort, followed with prospective life charts, who discontinued lithium and had a second lithium treatment. Patients who had at least 2 mood episodes when they were drug naïve to describe the natural frequency of illness and 3 mood episodes before the discontinuation were included...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27972878/clinical-outcomes-of-bipolar-disorder-on-long-term-treatment-with-lithium-with-or-without-mood-stabilizers
#17
G Q De Guzman, Virgen Milagrosa
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27941079/the-international-college-of-neuro-psychopharmacology-cinp-treatment-guidelines-for-bipolar-disorder-in-adults-cinp-bd-2017-part-3-the-clinical-guidelines
#18
REVIEW
Konstantinos N Fountoulakis, Heinz Grunze, Eduard Vieta, Allan Young, Lakshmi Yatham, Pierre Blier, Siegfried Kasper, Hans Jurgen Moeller
BACKGROUND: The current paper introduces the actual CINP clinical guidelines for the treatment of Bipolar disorder (BD). CONCEPT AND STRUCTURE OF THE GUIDELINES: The current clinical guidelines are based on evidence based data, but they also intend to be clinically useful, while a rigid algorithm was developed on the basis of firm evidence alone. Monotherapy was prioritised over combination therapy. There are separate recommendations for each of the major phases of BD expressed as a five-step algorithm...
December 10, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27933713/antipsychotic-adjunctive-therapy-to-mood-stabilizers-and-1-year-rehospitalization-rates-in-bipolar-disorder-a-cohort-study
#19
Eldar Hochman, Amir Krivoy, Ayal Schaffer, Abraham Weizman, Avi Valevski
OBJECTIVES: Antipsychotic adjunctive therapy to mood stabilizers (MSs) may improve relapse prevention; however, only a few naturalistic studies, reflecting more generalizable bipolar disorder (BD) samples, support this notion. We compared the 1-year rehospitalization rates of manic patients with bipolar I disorder (BD-I) who were discharged with MS (lithium or valproate) monotherapy or with adjunctive atypical or typical antipsychotic therapy. METHODS: A total of 201 patients with BD-I who were hospitalized with manic episodes between 2005 and 2013 were retrospectively followed for 1-year rehospitalization rates according to treatment at discharge: MS monotherapy, MS with atypical antipsychotics, and MS with typical antipsychotics...
December 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27923663/pharmacogenetics-of-lithium-effects-on-glomerular-function-in-bipolar-disorder-patients-under-chronic-lithium-treatment-a-pilot-study
#20
Evangelia Eirini Tsermpini, Yanfei Zhang, Paola Niola, Caterina Chillotti, Raffaella Ardau, Alberto Bocchetta, George P Patrinos, Maria Del Zompo, Giovanni Severino, Ming Ta Michael Lee, Alessio Squassina
Bipolar disorder (BD) is a psychiatric disease characterized by alternating episodes of mania and depression. Lithium (Li) represents the mainstay treatment for BD, although a significant proportion of patients shows insufficient or no response. Li is also associated with potentially severe side effects, including renal effects. Several studies reported that Li may induce reduction of glomerular filtration rate (GFR) in patients under long-term treatment. The biological systems and the genetic factors involved in susceptibility to Li-induced renal-side effects have been scarcely explored...
December 5, 2016: Neuroscience Letters
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