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https://www.readbyqxmd.com/read/29331701/the-use-of-triiodothyronine-t3-in-the-treatment-of-bipolar-depression-a-review-of-the-literature
#1
REVIEW
T Parmentier, P Sienaert
BACKGROUND: There is a paucity of treatment options for bipolar depression. The use of triiodothyronine (T3) has been suggested as adjunctive treatment. METHODS: A search on Medline, Limo and ScienceDirect was performed using the search terms bipolar disorder, bipolar depression, treatment resistant, treatment refractory, thyroid hormones, triiodothyronine, T3, acceleration and augmentation. RESULTS: We retrieved three open studies, one comparative study, two double blind and one retrospective chart review...
January 9, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331696/does-early-response-predict-subsequent-remission-in-bipolar-depression-treated-with-repeated-sleep-deprivation-combined-with-light-therapy-and-lithium
#2
Masahiro Suzuki, Sara Dallaspezia, Clara Locatelli, Makoto Uchiyama, Cristina Colombo, Francesco Benedetti
BACKGROUND: The combination of three cycles of sleep deprivation (SD), light therapy (LT), and lithium has recently been proposed as a possible first-line treatment for bipolar depression. However, it is unclear whether early improvement predicts final response/remission in bipolar depression treated with this regimen. METHOD: We studied 220 consecutively admitted inpatients with a major depressive episode in the course of bipolar disorder. The relation between response to first SD and response/remission at the end of the treatment (day 6) was analyzed using logistic regression analysis...
January 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29329498/treatment-outcomes-of-acute-bipolar-depressive-episode-with-psychosis
#3
Marco Antonio Caldieraro, Steven Dufour, Louisa G Sylvia, Keming Gao, Terence A Ketter, William V Bobo, Samantha Walsh, Jessica Janos, Mauricio Tohen, Noreen A Reilly-Harrington, Susan L McElroy, Richard C Shelton, Charles L Bowden, Thilo Deckersbach, Andrew A Nierenberg
BACKGROUND: The impact of psychosis on the treatment of bipolar depression is remarkably understudied. The primary aim of this study was to compare treatment outcomes of bipolar depressed individuals with and without psychosis. The secondary aim was to compare the effect of lithium and quetiapine, each with adjunctive personalized treatments (APTs), in the psychotic subgroup. METHODS: We assessed participants with DSM-IV bipolar depression included in a comparative effectiveness study of lithium and quetiapine with APTs (the Bipolar CHOICE study)...
January 12, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29310970/lithium-stress-and-resilience-in-bipolar-disorder-deciphering-this-key-homeostatic-synaptic-plasticity-regulator
#4
REVIEW
Rodrigo Machado-Vieira
BACKGROUND: Lithium is the lightest metal and the only mood stabilizer that has been used for over half a century for the treatment of bipolar disorder (BD). As a small ion, lithium is omnipresent, and consequently, its molecular mechanisms and targets are widespread. Currently, lithium is a crucial pharmacotherapy for the treatment of acute mood episodes, prophylactic therapy, and suicide prevention in BD. Besides, lithium blood level is the most widely used biomarker in clinical psychiatry...
December 22, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29301431/more-efforts-needed-to-clarify-the-effect-of-lithium-in-bipolar-disorder-response-to-terao-et-al
#5
Mikael Landén, Jie Song
No abstract text is available yet for this article.
January 1, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29301424/mixed-features-in-bipolar-i-disorder-and-the-effect-of-lithium-on-suicide
#6
Takeshi Terao, Masayuki Kanehisa, Ippei Shiotsuki, Nobuyoshi Ishii
No abstract text is available yet for this article.
January 1, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29298279/severe-chronic-lithium-intoxication-in-patient-treated-for-bipolar-disorder
#7
Ivana Stetkarova, Vaclav Bocek, Alsu Gismatullina, Zuzana Svobodova, Tomas Peisker
OBJECTIVE: Lithium has been long used in psychiatry as an adjuvant treatment for bipolar disorder. Chronic lithium intoxication is very rare. DESIGN: We present the case of a 72-year-old female, treated with lithium for more than 10 years for bipolar disorder, who was admitted for gait impairment with weakness of limbs, myoclonus, speech impairment and memory disturbances. RESULTS: Diagnosis of lithium intoxication was based on clinical picture and determination of serum lithium levels...
December 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29283064/glycogen-synthase-kinase-3%C3%AE-as-a-putative-therapeutic-target-for-bipolar-disorder
#8
Manoj P Dandekar, Samira S Valvassori, Gustavo Colombo Dal-Pont, Joao L DeQuevedo
BACKGROUND: Bipolar disorder (BD) is a debilitating mental ailment characterized by recurrent episodes of mania and depression. Primary mood-stabilizing drugs like lithium and valproate alleviate the hypomanic or mild to moderate manic episodes in patients with BD. One of the extensively studied underlying mechanisms for these pharmacological interventions is inhibition of intracellular signaling cascades associated with glycogen synthase kinase-3 beta (GSK-3β), a multi-functional serine-threonine kinase...
December 27, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29274567/is-there-consensus-across-international-evidence-based-guidelines-for-the-psychotropic-drug-management-of-bipolar-disorder-during-the-perinatal-period
#9
REVIEW
Rebecca K Graham, Gabriela Tavella, Gordon B Parker
BACKGROUND: Clinicians treating a patient with bipolar disorder who is pregnant or breastfeeding may seek advice from bipolar management guidelines that provide recommendations for perinatal treatment. We examine the consistency of such recommendations across several evidence-based guidelines. METHODS: A literature search in the National Guideline Clearinghouse, the Cochrane Database of Systematic Reviews, PsycInfo and PubMed was undertaken using the search terms "bipolar disorder" and "guidelines," which generated 11 sets of evidence-based guidelines published by professional organizations during the 2005-2015 period...
December 12, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29261491/-bipolar-disorder-advances-in-the-prediction-of-lithium-response-and-development-of-new-therapies-using-induced-pluripotent-stem-cells
#10
Renata Santos, Patrick Charnay
No abstract text is available yet for this article.
December 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29260296/lithium-associated-hypercalcemia-pathophysiology-prevalence-management
#11
Adrian D Meehan, Ruzan Udumyan, Mathias Kardell, Mikael Landén, Johannes Järhult, Göran Wallin
BACKGROUND: Lithium-associated hypercalcemia (LAH) is an ill-defined endocrinopathy. The aim of the present study was to determine the prevalence of hypercalcemia in a cohort of bipolar patients (BP) with and without concomitant lithium treatment and to study surgical outcomes for lithium-associated hyperparathyroidism. METHODS: Retrospective data, including laboratory results, surgical outcomes and medications, were collected from 313 BP treated with lithium from two psychiatric outpatient units in central Sweden...
December 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29260083/lithium-induced-downbeat-nystagmus
#12
Flora Schein, Pierre Manoli, Pascal Cathébras
We report the case of a 76-year old lady under lithium carbonate for a bipolar disorder who presented with a suspected optic neuritis. A typical lithium-induced downbeat nystagmus was observed. Discontinuation of lithium therapy resulted in frank improvement in visual acuity and disappearance of the nystagmus.
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29250539/xanthine-catechin-mixture-enhances-lithium-induced-anti-inflammatory-response-in-activated-macrophages-in-vitro
#13
Fernanda Barbisan, Verônica Farina Azzolin, Cibele Ferreira Teixeira, Moisés Henrique Mastella, Euler Esteves Ribeiro, Pedro Antonio Schmidt do Prado-Lima, Raquel de Souza Praia, Marta Maria Medeiros Frescura Duarte, Ivana Beatrice Mânica da Cruz
Lithium (Li) is a chemical element used for treating and preventing bipolar disorder (BD) and exerts positive effects such as anti-inflammatory effects as well as undesirable side effects. These effects of Li can be influenced by interaction with some nutritional elements. Therefore, we investigated the potential effects of xanthine (caffeine and theobromine) and catechin molecules present in some food beverages broadly consumed worldwide, such as coffee and tea, on Li-induced anti-inflammatory effects. In the present study, we concomitantly exposed RAW 264...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29247520/lithium-induced-electrocardiographic-changes-a-complete-review
#14
REVIEW
Nikhil Mehta, Robert Vannozzi
Lithium has been used for the treatment of bipolar disorder for more than 6 decades. Reports of cardiac side effects resulting in both benign electrocardiographic (ECG) changes and near fatal arrhythmias have been reported in the literature. A systematic literature search was conducted on 2 electronic databases-PubMed and Medline-for the time period between January 1970 and March 2016 using the key word "lithium," along with "electrocardiography" or "ECG." All articles and their references were then screened by title for relevance by 2 authors and a librarian...
December 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29245092/predictors-of-hospitalization-length-of-stay-among-re-admitted-treatment-resistant-bipolar-disorder-inpatients
#15
M Fornaro, F Iasevoli, S Novello, A Fusco, A Anastasia, D De Berardis, A Valchera, A de Bartolomeis
BACKGROUND: Hospitalization accounts for significant health care resource utilization for treatment-resistant Bipolar Disorder (BD), especially among frequent users of acute inpatient psychiatric units. Appraisal of the clinical features and predictive role of selected variables is therefore crucial in such population, representing the aim of the present research. METHODS: A hundred and nineteen BD inpatients with an established history of pharmacological treatment resistance for either mania or bipolar depression were classified as long hospitalization cases (LOS+) and their controls and compared against each other for a number of demographic, clinical, and psychopathological features...
December 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29234900/trace-lithium-and-mental-health
#16
REVIEW
Nobuyoshi Ishii, Takeshi Terao
Lithium therapy is generally accepted as a first-line treatment for bipolar disorder, and it is also identified as one of the best augmenting options for treatment-resistant depression. Furthermore, lithium has been investigated in association with suicide, dementia and aggressiveness. In this review, we examined articles about the effects of very small amounts of lithium in treating suicide, dementia, bipolar disorder and temperament, to assess the present state of trace lithium's effect on mental state. The results indicate that trace lithium may be effective for suicide prevention but randomized, placebo-controlled trials are required to draw a definite conclusion...
December 12, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29232923/an-oldie-but-goodie-lithium-in-the-treatment-of-bipolar-disorder-through-neuroprotective-and-neurotrophic-mechanisms
#17
REVIEW
Eunsoo Won, Yong-Ku Kim
Lithium has been used for the treatment of bipolar disorder (BD) for the last sixty or more years, and recent studies with more reliable designs and updated guidelines have recommended lithium to be the treatment of choice for acute manic, mixed and depressive episodes of BD, along with long-term prophylaxis. Lithium's specific mechanism of action in mood regulation is progressively being clarified, such as the direct inhibition on glycogen synthase kinase 3β, and its various effects on neurotrophic factors, neurotransmitters, oxidative metabolism, apoptosis, second messenger systems, and biological systems are also being revealed...
December 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29232311/lithium-colchicine-a-potential-strategy-to-reduce-pro-inflammatory-effects-of-lithium-treatment
#18
John J Mooney, Roscoe O Brady
PURPOSE: Rosenblat and McIntyre (Acta Psychiatr Scand. 2015;132: 180-191) propose that immune disorders are important mediators between bipolar disorders and medical comorbidities. Rosenblat et al (Bipolar Disord. 2016;18:89-101) present a meta-analysis showing that adjunctive anti-inflammatory agents could evoke moderate antidepressant responses in bipolar disorders. We propose using the anti-inflammatory drug colchicine to improve the long-term safety and efficacy of lithium treatment for bipolar disorders...
February 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29228982/electroconvulsive-therapy-for-manic-state-with-mixed-and-psychotic-features-in-a-teenager-with-bipolar-disorder-and-comorbid-episodic-obsessive-compulsive-disorder-a-case-report
#19
Olof Rask, Klara Suneson, Eva Holmström, Beata Bäckström, Björn Axel Johansson
BACKGROUND: Comorbidity of bipolar disorder and obsessive-compulsive disorder is common in adolescence. Obsessive-compulsive disorder symptoms may be episodic and secondary to alterations in mood, and display specific features. Management of pediatric bipolar disorder-obsessive-compulsive disorder is challenging, as pharmacotherapy of obsessive-compulsive disorder may induce or exacerbate manic episodes and there is limited evidence of treatment efficacy. Electroconvulsive therapy is sparsely used in children and adolescents, but is documented to be a safe and efficacious intervention in adults with bipolar disorder...
December 12, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29227034/the-clinical-course-of-late-life-bipolar-disorder-looking-back-and-forward
#20
Annemiek Dols, Nicole Korten, Hannie Comijs, Sigfried Schouws, Moniek van Dijk, Ursula Klumpers, Aartjan Beekman, Ralph Kupka, Max Stek
OBJECTIVES: Little is known about the course of late-life bipolar disorder (LLBD). First, we studied patients with LLBD retrospectively with regard to age at first mood episode, onset polarity, predominant polarity and episode density and its associations with other clinical variables. Next, we examined prospectively the clinical course and its associated factors. METHODS: Data were used from a dynamic cohort (Dutch Older Bipolars [DOBi]) including 101 patients with LLBD (mean age of 68...
December 11, 2017: Bipolar Disorders
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