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https://www.readbyqxmd.com/read/28636505/the-effect-of-aerobic-interval-training-and-continuous-training-on-exercise-capacity-and-its-determinants
#1
Nele Pattyn, Paul J Beckers, Véronique A Cornelissen, Ellen Coeckelberghs, Catherine De Maeyer, Geert Frederix, Kaatje Goetschalckx, Nadine Possemiers, Dirk Schepers, Emeline M Van Craenenbroeck, Kurt Wuyts, Viviane M Conraads, Luc Vanhees
Objective We aimed to investigate (1) the effects of aerobic interval training (AIT) and aerobic continuous training (ACT) on (sub)maximal exercise measures and its determinants including endothelial function, muscle strength and cardiac autonomic function, and (2) the relationship between exercise capacity and these determinants. Methods Two-hundred coronary artery disease (CAD) patients (58.4 ± 9.1 years) were randomized to AIT or ACT for 12 weeks. All patients performed a cardiopulmonary exercise test and endothelial function measurements before and after the intervention; a subpopulation underwent muscle strength and heart rate variability (HRV) assessments...
March 21, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28635652/fucaceae-a-source-of-bioactive-phlorotannins
#2
REVIEW
Marcelo D Catarino, Artur M S Silva, Susana M Cardoso
Fucaceae is the most dominant algae family along the intertidal areas of the Northern Hemisphere shorelines, being part of human customs for centuries with applications as a food source either for humans or animals, in agriculture and as remedies in folk medicine. These macroalgae are endowed with several phytochemicals of great industrial interest from which phlorotannins, a class of marine-exclusive polyphenols, have gathered much attention during the last few years due to their numerous possible therapeutic properties...
June 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28635550/peptide-grafted-and-self-assembled-poly-%C3%AE-glutamic-acid-phenylalanine-nanoparticles-targeting-camptothecin-to-glioma
#3
Hitesh Kulhari, Srinivasa R Telukutla, Deep Pooja, Ravi Shukla, Ramakrishna Sistla, Vipul Bansal, David J Adams
AIM: To synthesize cRGDfK peptide conjugated poly(γ-glutamic acid)-phenylalanine nanoparticles to improve the therapeutic efficacy of camptothecin (CPT) against glioblastoma multiforme. METHODS: Peptide-conjugated, drug-loaded nanoparticles (cRGDfK-conjugated camptothecin-loaded PGA-PA nanoparticles [RCPN]) were prepared and physico-chemically characterized using different techniques. Nanoparticles were evaluated for in vitro anticancer activity, cellular uptake, induction of apoptosis and wound healing cell migration against U87MG human glioblastoma cells...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28634686/respiratory-uptake-and-depuration-kinetics-of-perfluorooctanesulfonate-pfos-in-a-marine-sandworm-species
#4
Takeo Sakurai, Jun Kobayashi, Nozomi Ito, Shigeko Serizawa, Hiroaki Shiraishi, Tohru Yabe, Yuichi Ishii, Noriyuki Suzuki
We determined the respiratory uptake and depuration kinetics of perfluorooctanesulfonate (PFOS) in Perinereis wilsoni, a polychaete sandworm used as a model species to investigate the fate of chemical pollutants in coastal environments. The sandworms were kept in gravel-packed containers, and the water levels were varied cyclically to mimic the tides. We used seawater kept at 17.1°C. A 7-day exposure period was followed by a 9-day depuration period. The dissolved PFOS concentration averaged 28 ng/L during the exposure period...
June 20, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28634587/exercise-metabolism-in-nonobese-patients-with-type-2-diabetes-following-the-acute-restoration-of-normoglycaemia
#5
Christopher J Gaffney, Peter Mansell, Francis B Stephens, Ian A Macdonald, Kostas Tsintzas
This study investigated how acute restoration of normoglycaemia affected energy metabolism during exercise in nonobese patients with type 2 diabetes. Six subjects (mean ± SEM) aged 56.2 ± 2.7 years, with a BMI of 24.5 ± 1.5 kg/m(2) and a VO2 peak of 28.7 ml/kg/min, attended the lab on two randomised occasions for a four-hour resting infusion of insulin or saline, followed by 30 minutes cycling at 50% VO2 peak. During the 4 h resting infusion, there was a greater (P < 0.0001) reduction in blood glucose in insulin treatment (INS) (from 11...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28630426/the-down-regulation-of-slc7a11-enhances-ros-induced-p-gp-over-expression-and-drug-resistance-in-mcf-7-breast-cancer-cells
#6
Chun Ge, Bei Cao, Dong Feng, Fang Zhou, Jingwei Zhang, Na Yang, Siqi Feng, Guangji Wang, Jiye Aa
Adriamycin (ADR) induces the over-expression of P-glycoprotein (P-gp) and multiple drug resistance in breast cancer cells. However, the biochemical process and underlying mechanisms are not clear. Our previous study revealed that ADR increased reactive oxygen species (ROS) generation and decreased glutathione (GSH) biosynthesis, while N-acetylcysteine, the ROS scavenger, reversed the over-expression of P-gp. The present study showed that ADR inhibited the influx of cystine (the source material of GSH) and the activity of the SLC7A11 transporter (in charge of cystine uptake) in MCF-7 cells...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629086/enhancing-internalization-of-silica-particles-in-myocardial-cells-through-surface-modification
#7
Nancy Ornelas-Soto, Rodrigo Rubio-Govea, Carlos E Guerrero-Beltrán, Eduardo Vázquez-Garza, Judith Bernal-Ramírez, Alejandra García-García, Yuriana Oropeza-Almazán, Gerardo García-Rivas, Flavio F Contreras-Torres
Surface modification in nanostructured mesoporous silica particles (MSNs) can significantly increase the uptake in myocardial cells. Herein, MSNs particles were synthesized and chemically functionalized to further assess their biocompatibility in rat myocardial cell line H9c2. The surface modification resulted in particles with an enhanced cellular internallization (3-fold increase) with respect to pristine particles. Apoptosis events were not evident at all, while necrosis incidence was significant only at a higher doses (>500μg/mL)...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629072/photodynamic-effect-of-light-harvesting-long-lived-triplet-excited-state-ruthenium-ii-polyimine-coumarin-complexes-dna-binding-photocleavage-and-anticancer-studies
#8
Raju Nomula, Xueyan Wu, Jianzhang Zhao, Nagegownivari R Munirathnam
Two coumarin based Ru(II)-polyimine complexes (Ru-1 and Ru-2) showing intense absorption of visible light and long-lived triplet excited states (~12-15μs) were used for study of the interaction with DNA. The binding of the complexes with CT-DNA were studied by UV-vis, fluorescence and time-resolved nanosecond transient absorption (ns-TA) spectroscopy. The results suggesting that the complexes interact with CT-DNA by intercalation mode of binding, showing the binding constants (Kb) 6.47×10(4) for Ru-1 and 5...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28627041/prior-exercise-speeds-pulmonary-oxygen-uptake-kinetics-and-increases-critical-power-during-supine-but-not-upright-cycling
#9
Richie P Goulding, Denise M Roche, Simon Marwood
Critical power (CP) is a fundamental parameter defining high-intensity exercise tolerance and is related to the time constant of phase II pulmonary oxygen uptake kinetics (τV̇O2 ). To test the hypothesis that this relationship is causal we determined the impact of prior exercise ("priming") on CP and τV̇O2 in the upright and supine positions. 17 healthy men were assigned to either upright or supine exercise groups, whereby CP, τV̇O2 and muscle deoxyhaemoglobin kinetics (τ[HHb] ) were determined via constant-power tests to exhaustion at four work-rates with (primed) and without (control) priming exercise at ∼31%Δ...
June 19, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28626897/ultrastable-near-infrared-conjugated-polymer-nanoparticles-for-dually-photoactive-tumor-inhibition
#10
Tao Yang, Ling Liu, Yibin Deng, Zhengqing Guo, Guobing Zhang, Zhishen Ge, Hengte Ke, Huabing Chen
It is highly desired that satisfactory photoactive agents with ideal photophysical characteristics are explored for potent cancer phototherapeutics. Herein, bifunctional nanoparticles of low-bandgap donor-acceptor (D-A)-type conjugated-polymer nanoparticles (CP-NPs) are developed to afford a highly efficient singlet-to-triplet transition and photothermal conversion for near-infrared (NIR) light-induced photodynamic (PDT)/photothermal (PTT) treatment. CP-NPs display remarkable NIR absorption with the peak at 782 nm, and perfect resistance to photobleaching...
June 19, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28626304/obesity-and-low-back-pain-a-retrospective-cohort-study-of-japanese-males
#11
Yuko Hashimoto, Ko Matsudaira, Susumu S Sawada, Yuko Gando, Ryoko Kawakami, Chihiro Kinugawa, Takashi Okamoto, Koji Tsukamoto, Motohiko Miyachi, Hisashi Naito
[Purpose] This study evaluated whether obesity is a risk factor for low back pain, by using body fat percentage (%FAT) and body mass index (BMI) as indices of obesity among Japanese males. [Subjects and Methods] This study included 1,152 males (average age: 28.0 ± 4.6 years). BMI was calculated from subject's height and weight, and %FAT was estimated by the thickness of two parts of skin. Low back pain, drinking and smoking were surveyed using a self-administered questionnaire, and maximal oxygen uptake was measured by a submaximal exercise test using a cycle ergometer...
June 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28625994/a-small-protein-hemp-is-a-transcriptional-activator-for-hemin-uptake-operon-in-burkholderia-multivorans-atcc-17616
#12
Takuya Sato, Shouta Nonoyama, Akane Kimura, Yuji Nagata, Yoshiyuki Ohtsubo, Masataka Tsuda
Iron and heme play very important roles in various metabolic functions in bacteria, and their intracellular homeostasis is maintained because high concentrations of free forms of these molecules greatly facilitate the Fenton reaction-mediated production of large amounts of reactive oxygen species that severely damage various biomolecules. Ferric uptake regulator (Fur) from Burkholderiamultivorans ATCC 17616 is an iron-responsive global transcriptional regulator, and its fur deletant exhibits pleiotropic phenotypes...
June 16, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28624590/maleic-acid-assisted-improvement-of-metal-chelation-and-antioxidant-metabolism-confers-chromium-tolerance-in-brassica-juncea-l
#13
Jubayer Al Mahmud, Mirza Hasanuzzaman, Kamrun Nahar, Anisur Rahman, Md Shahadat Hossain, Masayuki Fujita
Chromium (Cr) is a highly toxic environmental pollutant that negatively affects plant growth and development. Thus, remediating Cr from soil or increasing plant tolerance against Cr stress is urgent. Organic acids are recognized as agents of phytoremediation and as exogenous protectants, but using maleic acid (MA) to attain these results has not yet been studied. Therefore, our study investigated the effects of MA on Cr uptake and mitigation of Cr toxicity. We treated 8-d-old Indian mustard (Brassica juncea L...
June 15, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28624444/distribution-lipid-bilayer-affinity-and-kinetics-of-the-metabolic-effects-of-dinoseb-in-the-liver
#14
Gabriela Bueno Franco Salla, Lívia Bracht, Anacharis Babeto de Sá-Nakanishi, Angela Valderrama Parizotto, Fabrício Bracht, Rosane Marina Peralta, Adelar Bracht
Dinoseb is a highly toxic pesticide of the dinitrophenol group. Its use has been restricted, but it can still be found in soils and waters in addition to being a component of related pesticides that, after ingestion by humans or animals, can originate the compound by enzymatic hydrolysis. As most dinitrophenols, dinoseb uncouples oxidative phosphorylation. In this study, distribution, lipid bilayer affinity and kinetics of the metabolic effects of dinoseb were investigated, using mainly the isolated perfused rat liver, but also isolated mitochondria and molecular dynamics simulations...
June 14, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28624442/loss-of-fructose-1-6-bisphosphatase-induces-glycolysis-and-promotes-apoptosis-resistance-of-cancer-stem-like-cells-an-important-role-in-hexavalent-chromium-induced-carcinogenesis
#15
Jin Dai, Yanli Ji, Wei Wang, Donghern Kim, Leonard Yenwong Fai, Lei Wang, Jia Luo, Zhuo Zhang
Hexavalent chromium (Cr(VI)) compounds are confirmed human carcinogens for lung cancer. Our previous studies has demonstrated that chronic exposure of human bronchial epithelial BEAS-2B cells to low dose of Cr(VI) causes malignant cell transformation. The acquisition of cancer stem cell-like properties is involved in the initiation of cancers. The present study has observed that a small population of cancer stem-like cells (BEAS-2B-Cr-CSC) exists in the Cr(VI)-transformed cells (BEAS-2B-Cr). Those BEAS-2B-Cr-CSC exhibit extremely reduced capability of generating reactive oxygen species (ROS) and apoptosis resistance...
June 14, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28624095/fontan-circulation-over-time
#16
Djoeke Wolff, Joost P van Melle, Beatrijs Bartelds, Floris-Jan S Ridderbos, Graziella Eshuis, Elisabeth B H J van Stratum, Salvador J Recinos, Brigitte W M Willemse, Hans Hillege, Tineke P Willems, Tjark Ebels, Rolf M F Berger
The unique, unphysiological Fontan circulation is associated with an impaired functional status of the patients that is suggested to deteriorate over time. Unfortunately, previous studies did not integrate both pulmonary and cardiac determinants of functional status. In addition, a comparison with the natural decrease in exercise capacity in healthy subjects (in both children and adults) is lacking. This single-center study aims to investigate the functional status in a cohort of Fontan patients in relation to time since Fontan completion and to identify its determinants, including cardiac characteristics and pulmonary characteristics...
May 11, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28623259/microrna-34a-encapsulated-in-hyaluronic-acid-nanoparticles-induces-epigenetic-changes-with-altered-mitochondrial-bioenergetics-and-apoptosis-in-non-small-cell-lung-cancer-cells
#17
Malav Trivedi, Amit Singh, Meghna Talekar, Grishma Pawar, Parin Shah, Mansoor Amiji
Therapies targeting epigenetic changes for cancer treatment are in Phase I/II trials; however, all of these target only nuclear DNA. Emerging evidence suggests presence of methylation marks on mitochondrial DNA (mtDNA); but their contribution in cancer is unidentified. Expression of genes encoded on mtDNA are altered in cancer cells, along with increased glycolytic flux. Such glycolytic flux and elevated reactive oxygen species is supported by increased antioxidant; glutathione. MicroRNA-34a can translocate to mitochondria, mediate downstream apoptotic effects of tumor suppressor P53, and inhibit the antioxidant response element Nrf-2, resulting in depleted glutathione levels...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28622608/a-comparative-study-of-the-mechanical-behaviour-of-thermally-oxidised-commercially-pure-titanium-and-zirconium
#18
A Alansari, Y Sun
The objective of this study is to compare the mechanical behaviour of thermally oxidised commercially pure titanium (CP-Ti) and commercially pure zirconium (CP-Zr). For this purpose, these two bio-metals were thermally oxidised under the same condition (650°C for 6h) and the oxidised specimens were characterised using various analytical and experimental techniques, including oxygen uptake analysis, layer thickness and hardness measurements, scratch tests, dry sliding friction and wear tests and tribocorrosion tests in Ringer's solution...
June 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28622568/per-protocol-investigation-of-a-best-practice-exercise-referral-scheme
#19
L Stewart, E Dolan, P Carver, P A Swinton
OBJECTIVES: To investigate the effects of an exercise referral scheme (ERS) aligned to the UK best practice guidelines on a range of outcomes including those associated with key health concerns of the Scottish population. STUDY DESIGN: A longitudinal design with data collection at three time points (baseline, midway and post) during a 12-week ERS intervention was employed. METHODS: Health-related physical fitness was assessed through measurement of resting heart rate, blood pressure, FEV1:FEV6 (ratio of forced expiratory volume over one [FEV1] and six [FEV6] seconds), body mass and peak oxygen uptake (VO2 peak), whilst functional capacity was assessed through the five times sit to stand test...
June 12, 2017: Public Health
https://www.readbyqxmd.com/read/28621882/exercise-capacity-and-functional-performance-in-heart-failure-patients-supported-by-a-left-ventricular-assist-device-at-discharge-from-inpatient-rehabilitation
#20
Thomas Schmidt, Birna Bjarnason-Wehrens, Petra Bartsch, Ezin Deniz, Jan Schmitto, Sebastian Schulte-Eistrup, Detlev Willemsen, Nils Reiss
Adequate physical and functional performance is an important prerequisite for renewed participation and integration in self-determined private and (where appropriate) professional lives following left ventricular assist device (LVAD) implantation. During cardiac rehabilitation (CR), individually adapted exercise programs aim to increase exercise capacity and functional performance. A retrospective analysis of cardiopulmonary exercise capacity and functional performance in LVAD patients at discharge from a cardiac rehabilitation program was conducted...
June 16, 2017: Artificial Organs
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