Read by QxMD icon Read

Oxygen uptake

Samuel A Pullinger, Juha Oksa, Emma L Brocklehurst, Reece P Iveson, Antonia Newlove, Jatin G Burniston, Dominic A Doran, James M Waterhouse, Ben J Edwards
The present study investigated whether increasing morning rectal temperatures (Trec ) to resting.evening levels, or decreasing evening Trec or muscle (Tm ) temperatures to morning values, would influence repeated sprint (RS) performance in a causal manner. Twelve trained males underwent five sessions [age (mean ± SD) 21.8 ± 2.6 yr, peak oxygen uptake ([Formula: see text] peak) 60.6 ± 4.6 mL kg min-1 , stature 1.78 ± 0.07 m and body mass 76.0 ± 6.3 kg]. These included a control morning (M, 07:30 h) and evening (E, 17:30 h) session (5-min warm-up), and three further sessions consisting of a warm-up morning trial (ME , on a motorised treadmill) until Trec reached evening levels; and two cool-down evening trials (in 16-17°C water) until Trec (EMrec ) or Tm (EMmuscle ) values reached morning temperatures, respectively...
March 20, 2018: Chronobiology International
Cynthia Al Hageh, Majd Al Assaad, Zeinab El Masri, Nawar Samaan, Mirvat El-Sibai, Christian Khalil, Rony S Khnayzer
Copper is an earth-abundant and a biologically essential metal that offers a promising alternative to noble metals in photochemistry and photobiology. In this work, a series of sterically encumbered Cu(i) bis-phenanthroline complexes were investigated for their use in photochemotherapy (PCT). It was found that Cu(dsbtmp)2+ [dsbtmp = 2,9-disec-butyl-3,4,7,8-tetramethyl-1,10-phenanthroline] (compound 3), which possessed the longest excited state lifetime, exhibited significant in vitro photocytotoxicity on A375 (human malignant melanoma) and A549 (human lung carcinoma) cell lines...
March 20, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Ji-Sun Kim, Hyunjung Lee, Chang Hwa Jung, Sung-Joon Lee, Tae-Youl Ha, Jiyun Ahn
Mitochondrial dysfunction is associated with insulin resistance. Although chicoric acid (CA) is known to have beneficial effects on insulin sensitivity, the involvement of mitochondrial function has not been elucidated yet. Here, we investigated the effect of CA on insulin resistance and mitochondrial dysfunction. In palmitate-induced insulin-resistant C2C12 myotubes, CA improved impaired glucose uptake and insulin signaling pathways, along with enhanced mitochondrial membrane potential and oxygen consumption...
March 20, 2018: Bioscience, Biotechnology, and Biochemistry
Tomohiro Gonjo, Carla McCabe, Ana Sousa, João Ribeiro, Ricardo J Fernandes, João Paulo Vilas-Boas, Ross Sanders
PURPOSE: The purpose of this study was to determine kinematic and energetic differences between front crawl and backstroke performed at the same aerobic speeds. METHODS: Ten male competitive swimmers performed front crawl and backstroke at a pre-determined sub-anaerobic threshold speed to assess energy cost (through oxygen uptake measurement) and kinematics (using three-dimensional videography to determine stroke frequency and length, intra-cycle velocity fluctuation, three-dimensional wrist and ankle speeds, and vertical and lateral ankle range of motion)...
March 19, 2018: European Journal of Applied Physiology
Graeme A Deuchar, David Brennan, William M Holmes, Martin Shaw, I Mhairi Macrae, Celestine Santosh
The ability to identify metabolically active and potentially salvageable ischaemic penumbra is crucial for improving treatment decisions in acute stroke patients. Our solution involves two complementary novel MRI techniques (Glasgow Oxygen Level Dependant (GOLD) Metabolic Imaging), which when combined with a perfluorocarbon (PFC) based oxygen carrier and hyperoxia can identify penumbra due to dynamic changes related to continued metabolism within this tissue compartment. Our aims were (i) to investigate whether PFC offers similar enhancement of the second technique (Lactate Change) as previously demonstrated for the T2 *OC technique (ii) to demonstrate both GOLD metabolic imaging techniques working concurrently to identify penumbra, following administration of Oxycyte® (O-PFC) with hyperoxia...
2018: Theranostics
Morten Kristoffersen, Øyvind Sandbakk, Espen Tønnessen, Ida Svendsen, Gøran Paulsen, Elisabeth Ersvær, Irene Nygård, Kari Rostad, Anita Ryningen, Vegard V Iversen, Knut Skovereng, Bent R Rønnestad, Hilde Gundersen
Purpose: Although strength and sprint training are widely used methods in competitive cycling, no previous studies have compared the acute responses and recovery rates following such sessions among highly trained cyclists. The primary aim of the current study was to compare power production and biochemical markers of metabolic stress and muscle damage following a session of heavy strength (HS) and short-sprint training (SS). Methods: Eleven well-trained male cyclists (18 ± 2 years with maximal oxygen uptake of 67...
2018: Frontiers in Physiology
Iain G Thomson, Matthew P Wallen, Adrian Hall, Rebekah Ferris, David C Gotley, Andrew P Barbour, Andrew Lee, Janine Thomas, Bernard M Smithers
Neoadjuvant therapy (NAT) for oesophageal cancer may reduce cardiopulmonary function, assessed by cardiopulmonary exercise testing (CPEX). Impaired cardiopulmonary function is associated with mortality following esophagectomy. We sought to assess the impact of NAT on cardiopulmonary function using CPEX and assessing the clinical relevance of any change in particular if changes were associated with post-operative morbidity. This was a prospective, cohort study of 40 patients in whom CPEX was performed before and after NAT...
March 16, 2018: International Journal of Surgery
Mitchell Kuss, Jiyoung Kim, Dianjun Qi, Shaohua Wu, Yuguo Lei, Soonkyu Chung, Bin Duan
Obesity and its related health complications cause billions of dollars in healthcare costs annually in the United States, and there are yet to be safe and long-lasting anti-obesity approaches. Using brown adipose tissue (BAT) is a promising approach, as it uses fats for energy expenditure. However, the effect of the microenvironment on human thermogenic brown adipogenesis and how to generate clinically relevant sized and functioning BAT are still unknown. In our current study, we evaluated the effects of endothelial growth medium exposure on brown adipogenesis of human brown adipose progenitors (BAP)...
March 16, 2018: Acta Biomaterialia
Maysa M Cruz, Andressa B Lopes, Amanda R Crisma, Roberta C C de Sá, Wilson M T Kuwabara, Rui Curi, Paula B M de Andrade, Maria I C Alonso-Vale
BACKGROUND: We have recently demonstrated that palmitoleic acid (16:1n7) increases lipolysis, glucose uptake and glucose utilization for energy production in white adipose cells. In the present study, we tested the hypothesis that palmitoleic acid modulates bioenergetic activity in white adipocytes. METHODS: For this, 3 T3-L1 pre-adipocytes were differentiated into mature adipocytes in the presence (or absence) of palmitic (16:0) or palmitoleic (16:1n7) acid at 100 or 200 μM...
March 20, 2018: Lipids in Health and Disease
João Henrique F Amaral, Alberto V Borges, John M Melack, Hugo Sarmento, Pedro M Barbosa, Daniele Kasper, Michaela L de Melo, Daniela De Fex-Wolf, Jonismar S da Silva, Bruce R Forsberg
We investigated plankton metabolism and its influence on carbon dioxide (CO2 ) dynamics in a central Amazon floodplain lake (Janauacá, 3°23' S, 60°18' W) from September 2015 to May 2016, including a period with exceptional drought. We made diel measurements of CO2 emissions to the atmosphere with floating chambers and depth profiles of temperature and CO2 partial pressure (pCO2 ) at two sites with differing wind exposure and proximity to vegetated habitats. Dissolved oxygen (DO) concentrations were monitored continuously during day and night in clear and dark chambers with autonomous optical sensors to evaluate plankton metabolism...
March 3, 2018: Science of the Total Environment
M X Lima, K Q Carvalho, F H Passig, A C Borges, T C Filippe, J C R Azevedo, A Nagalli
The present study aimed to assess removal potential of chemical oxygen demand (COD), total Kjeldahl nitrogen (TKN), total ammonia nitrogen (TAN), total phosphorus (TP) and acetylsalicylic acid (ASA) in synthetic wastewater simulating low-strength sewage by sequencing-batch mode constructed wetlands (CWs). Six CWs with three substrates (gravel, light expanded clay and clay bricks) and one CW of each substrate was planted with E. crassipes to verify the feasibility of using a floating macrophyte in CWs and verify the best optimized substrate...
March 3, 2018: Science of the Total Environment
Chia-Lun Lee, Yu-Hsuan Kuo, Ching-Feng Cheng
PURPOSE: To examine the effects of 2 exercise regimes on physiological and postprandial lipemic responses. METHODS: Thirty-six active men (peak oxygen uptake (VO2peak): 46.5 ± 6.4 mL/kg/min) were randomly assigned to a high-intensity interval exercise (HIIE), involving 10 × 60 s cycling at 85% VO2peak interspersed with 120 s recovery; a moderate-intensity continuous exercise (MICE), involving 50 min continuous exercise at 65% VO2peak; and a nonexercise control (Con)...
March 16, 2018: Medicine and Science in Sports and Exercise
Philipp S Orekhov, Ekaterina G Kholina, Marine E Bozdaganyan, Alexey M Nesterenko, Ilya B Kovalenko, Marina G Strakhovskaya
Phthalocyanines are aromatic macrocyclic compounds, which are structurally related to porphyrins. In clinical practice phthalocyanines are used in fluorescence imaging and photodynamic therapy of cancer and non-cancer lesions. Certain forms of the substituted polycationic metallophthalocyanines have been previously shown to be active in photodynamic inactivation of both Gram-negative and Gram-positive bacteria, one of them is zinc octakis(cholinyl)phthalocyanine (ZnPcChol8+ ). However, the molecular details of how these compounds translocate across bacterial membranes still remain unclear...
March 19, 2018: Journal of Physical Chemistry. B
Axel Pressler, Leonie Förschner, Jana Hummel, Bernhard Haller, Jeffrey W Christle, Martin Halle
Background Increased exercise capacity favourably influences clinical outcomes after transcatheter aortic valve implantation. In our SPORT:TAVI randomised pilot trial, eight weeks of endurance and resistance training (training group, TG) shortly after transcatheter aortic valve implantation resulted in significantly improved exercise capacity, muscular strength and quality of life compared to usual care (UC). However, the long-term clinical benefits of such an intervention are unknown. Design A randomised controlled trial...
January 1, 2018: European Journal of Preventive Cardiology
Patricia Palau, Eloy Domínguez, Laura López, José María Ramón, Raquel Heredia, Jessika González, Enrique Santas, Vicent Bodí, Gema Miñana, Ernesto Valero, Anna Mollar, Vicente Bertomeu González, Francisco J Chorro, Juan Sanchis, Josep Lupón, Antoni Bayés-Genís, Julio Núñez
INTRODUCTION AND OBJECTIVES: Despite the prevalence of heart failure with preserved ejection fraction (HFpEF), there is currently no evidence-based effective therapy for this disease. This study sought to evaluate whether inspiratory muscle training (IMT), functional electrical stimulation (FES), or a combination of both (IMT + FES) improves 12- and 24-week exercise capacity as well as left ventricular diastolic function, biomarker profile, and quality of life in HFpEF. METHODS: A total of 61 stable symptomatic patients (New York Heart Association II-III) with HFpEF were randomized (1:1:1:1) to receive a 12-week program of IMT, FES, or IMT + FES vs usual care...
March 15, 2018: Revista Española de Cardiología
Christopher S Jones, Sea-Won Kim, Thomas F Wilton, Keith E Schilling, Caroline A Davis
Real-time, continuous, in situ water quality sensors were deployed on a fourth-order Iowa (U.S.) stream draining an agricultural watershed to evaluate key in-stream processes affecting concentrations of nitrate during a 24-day late summer (Aug-Sep) period. Overall, nitrate-nitrogen (NO3 -N) concentrations declined 0.11 mg L-1  km-1 , or about 1.9% km-1 and 35% in total across 18 km. We also calculated stream metabolic rates using in situ dissolved oxygen data and determined stream biotic N demand to be 108-117 mg m-2  day-1 ...
March 17, 2018: Environmental Monitoring and Assessment
Ricardo Marques, Anna Ribera-Guardia, Jorge Santos, Gilda Carvalho, Maria A M Reis, Maite Pijuan, Adrian Oehmen
Denitrifying enhanced biological phosphorus removal (EBPR) systems can be an efficient means of removing phosphate (P) and nitrate (NO3 - ) with low carbon source and oxygen requirements. Tetrasphaera is one of the most abundant polyphosphate accumulating organisms present in EBPR systems, but their capacity to achieve denitrifying EBPR has not previously been determined. An enriched Tetrasphaera culture, comprising over 80% of the bacterial biovolume was obtained in this work. Despite the denitrification capacity of Tetrasphaera, this culture achieved only low levels of anoxic P-uptake...
March 7, 2018: Water Research
María E Alea-Reyes, Oriol Penon, Paula García Calavia, María J Marín, David A Russell, Lluïsa Pérez-García
HYPOTHESIS: Metalloporphyrins are extensively investigated for their ability to form reactive oxygen species and as potent photosensitisers for use in photodynamic therapy. However, their hydrophobicity generally causes solubility issues concerning in vivo delivery due to lack of distribution and low clearance from the body. Immobilising porphyrins on carriers, such as gold nanoparticles (GNP), can overcome some of these drawbacks. The mode of assembling the porphyrins to the carrier influences the properties of the resulting drug delivery systems...
March 7, 2018: Journal of Colloid and Interface Science
Michail E Keramidas, Roger Kölegård, Ola Eiken
Cold and hypoxia constitute the main environmental stressors encountered on the Antarctic Plateau. Hence, we examined whether central and/or peripheral acclimatisation to the combined stressors of cold and hypoxia would be developed in four men following an 11-day man-hauling expedition on this polar region. Before and after the journey, participants performed a static whole-body immersion in 21 °C water, during which they were breathing a hypoxic gas (partial pressure of inspired O2 : ~97 mmHg). To evaluate their local responses to cold, participants also immersed the hand into 8 °C water for 30 min, while they were whole-body immersed and mildly hypothermic [i...
April 2018: Journal of Thermal Biology
Nami Matsumoto, Hiromi Hattori, Minenosuke Matsutani, Chihiro Matayoshi, Hirohide Toyama, Naoya Kataoka, Toshiharu Yakushi, Kazunobu Matsushita
Thermotolerant microorganisms are beneficial to the fermentation industry because of a reduction in cooling efforts and other operational advantages. Previously, we have obtained a thermally adapted Gluconobacter frateurii strain by experimental evolution. In the present study, we found only a single G insertion in the adapted strain, which causes a frameshift in a gene encoding a putative drug transporter. A mutant derivative strain with the single G insertion in the transporter gene (Wild-G) was constructed from the wild-type strain and showed increased thermotolerance...
March 16, 2018: Applied and Environmental Microbiology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"