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https://www.readbyqxmd.com/read/28350966/cationic-phosphorus-dendrimer-enhances-photodynamic-activity-of-rose-bengal-against-basal-cell-carcinoma-cell-lines
#1
Monika Dabrzalska, Anna Janaszewska, Maria Zablocka, Serge Mignani, Jean Pierre Majoral, Barbara Klajnert-Maculewicz
In the last couple of decades, photodynamic therapy emerged as a useful tool in the treatment of basal cell carcinoma. However, it still meets limitations due to unfavorable properties of photosensitizers, such as poor solubility or lack of selectivity. Dendrimers - polymers widely studied in biomedical field - may play a role as photosensitizer carriers and improve the efficacy of photodynamic treatment. Here, we describe the evaluation of an electrostatic complex of cationic phosphorus dendrimer and rose bengal in such aspects as singlet oxygen production, cellular uptake and phototoxicity against three basal cell carcinoma cell lines...
March 28, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28350451/ros-switchable-polymeric-nanoplatform-with-stimuli-responsive-release-for-active-targeted-drug-delivery-to-breast-cancer
#2
Yu Zhang, Qin Guo, Sai An, Yifei Lu, Jianfeng Li, Xi He, Lisha Liu, Yujie Zhang, Tao Sun, Chen Jiang
Tumor microenvironment plays a vital role in the process of tumor development, proliferation, invasion, and metastasis. It is well acknowledged that reduction in pH, reactive oxygen species (ROS), and increased level of glucose transporter 1 (GLUT1) have become featured intracellular and extracellular biochemical markers of cancer owing to oncogenic transformation and abnormal metabolism. To establish a distinctive drug delivery system directed against the tumor microenvironment features, we develop a newly engineered polymeric nanoplatform for efficient doxorubicin (DOX) delivery with reduced systemic toxicity and high antitumor efficiency...
March 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28343134/exfoliated-graphene-nanosheets-ph-sensitive-drug-carrier-and-anti-cancer-activity
#3
Nisha Tyagi, Nour F Attia, Kurt E Geckeler
A straightforward and facile method for the exfoliation of graphene sheets using poly(vinylpyrrolidone) nanoparticles of an average size of 42nm was developed and their dual role as pH-sensitive drug carrier and anti-cancer agent was evaluated. The cytotoxic impact of the exfoliated nanosheets (GRP-PVP-NP) was examined on various cells (HCT-116, HeLa, SCC-9, NIH-3T3 and HEK-293cells) by a series of assays. Their cytotoxic nature was attributed to affecting the mitochondrial enzyme activity, proliferation capability, and the formation of tight junctions in cancer cells...
March 16, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28338413/human-tissue-engineered-skeletal-muscle-myobundles-to-measure-oxygen-uptake-and-assess-mitochondrial-toxicity
#4
Brittany N J Davis, Jeffrey W Santoso, Michaela J Walker, Cindy S Cheng, Timothy R Koves, William E Kraus, George A Truskey
Mitochondrial dysfunction is responsible for the toxicity of a number of drugs. Current isolated mitochondria or cellular monoculture mitochondrial respiration measurement systems lack physiological relevance. Using a tissue engineering rather than cell- or mitochondria-based approach enables a more physiologically relevant detection of drug-induced mitochondrial impairment. To probe oxygen consumption and mitochondrial health, we assayed the bioenergetic profile of engineered three-dimensional human skeletal muscle myobundles derived from primary myoblasts...
March 24, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28338378/validation-of-a-maximal-incremental-skating-test-performed-on-a-slide-board-comparison-with-treadmill-skating
#5
Tatiane Piucco, Fernando Diefenthaeler, Rogério Soares, Juan M Murias, Guillaume Y Millet
PURPOSE: the aim of this study was to investigate the criterion validity of a maximal incremental skating test performed on a slide board (SB). METHODS: Twelve sub-elite speed skaters performed a maximal skating test on a treadmill and on a SB. Gas exchange threshold (GET), respiratory compensation point (RCP) and maximal variables were determined. RESULTS: oxygen uptake (V̇O2) (31.0 ± 3.2 and 31.4 ± 4.1 mL∙min(-1)∙kg(-1)), percentage of maximal oxygen uptake (V̇O2max) (66...
March 24, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28338361/method-induced-differences-of-energy-contributions-in-adolescent-female-kayaking
#6
Yongming Li, Margot Niessen, Xiaoping Chen, Ulrich Hartmann
Purpose Different relative aerobic energy contribution (WAER%) has been reported for the two female Olympic kayaking disciplines (i.e. 200 and 500m). The purpose of this study was to investigate whether the adopted method of energy calculation influenced the value of WAER% during the kayaking time trials. Methods Eleven adolescent female kayakers (age 14±1 yrs, height 172±4 cm, body mass 65.4±4.2 kg, VO2peak 42.6±4.9 ml·min(-1)·kg(-1), training experience 1.5±0.3 yrs) volunteered to participate in one incremental exercise test and two time trials (40s and 120s) on the kayak ergometer...
March 24, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28338229/response-to-endurance-exercise-training-in-older-adults-with-heart-failure-with-preserved-or-reduced-ejection-fraction
#7
Ambarish Pandey, Dalane W Kitzman, Peter Brubaker, Mark J Haykowsky, Timothy Morgan, J Thomas Becton, Jarett D Berry
OBJECTIVES: To systematically examine the relative magnitude and predictors of responses to exercise training in older adult with heart failure (HF) with reduced ejection fraction (HFrEF), and preserved EF (HFpEF). DESIGN: Secondary analysis of a randomized controlled trial. SETTING: Outpatient cardiac rehabilitation program. PARTICIPANTS: Individuals with HF (24 HFrEF, 24 HFpEF) who underwent supervised exercise training...
March 24, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28337149/influence-of-inspiratory-muscle-training-on-ventilatory-efficiency-and-cycling-performance-in-normoxia-and-hypoxia
#8
Eduardo Salazar-Martínez, Hannes Gatterer, Martin Burtscher, José Naranjo Orellana, Alfredo Santalla
The aim of this study was to analyse the influence of inspiratory muscle training (IMT) on ventilatory efficiency, in normoxia and hypoxia, and to investigate the relationship between ventilatory efficiency and cycling performance. Sixteen sport students (23.05 ± 4.7 years; 175.11 ± 7.1 cm; 67.0 ± 19.4 kg; 46.4 ± 8.7 ml·kg(-1)·min(-1)) were randomly assigned to an inspiratory muscle training group (IMTG) and a control group (CG). The IMTG performed two training sessions/day [30 inspiratory breaths, 50% peak inspiratory pressure (Pimax), 5 days/week, 6-weeks]...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28337022/model-explanation-of-the-seasonal-variation-of-%C3%AE-18-o-in-cow-bos-taurus-hair-under-temperate-conditions
#9
Guo Chen, Hans Schnyder, Karl Auerswald
Oxygen isotopes (δ(18)O) in animal and human tissues are expected to be good recorders of geographical origin and migration histories. However, seasonal variation of δ(18)O may diminish the origin information in the tissues. Here the seasonality of δ(18)O in tail hair was investigated in a domestic suckler cow (Bos taurus) that underwent different ambient conditions, physiological states, keeping and feeding during five years. A detailed mechanistic model was built to explain this variation. The measured δ(18)O in hair significantly related (p < 0...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28336538/effects-of-dobutamine-on-intestinal-microvascular-blood-flow-heterogeneity-and-oxygen-extraction-during-septic-shock
#10
Gustavo Adolfo Ospina-Tascón, Alberto Federico García Marín, Gabriel J Echeverri, William Fernando Bermúdez, Humberto José Madriñán Navia, Juan David Valencia, Edgardo Quiñones, Fernando Rodríguez, Angela Marulanda, César Augusto Arango Davila, Alejandro Bruhn, Glenn Hernández, Daniel De Backer
Derangements of microvascular blood flow distribution might contribute to disturbing oxygen extraction by peripheral tissues. We evaluated the dynamic relationships between the mesenteric oxygen extraction ratio (mes-ERO2) and the heterogeneity of microvascular blood flow at the gut and sublingual mucosa, during the development and resuscitation of septic shock in a swine model of fecal peritonitis. Jejunal-villi and sublingual microcirculation were evaluated using a portable intravital-microscopy technique...
March 23, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28336535/the-effects-of-short-work-versus-longer-work-periods-within-intermittent-exercise-on-v%C3%AC-o2p-kinetics-muscle-deoxygenation-and-energy-system-contribution
#11
Michael Christopher McCrudden, Daniel A Keir, Glen R Belfry
We examined the effects of inserting 3 s recovery periods during high-intensity cycling exercise at 25 s and 10 s intervals on pulmonary oxygen uptake (V̇O2p), muscle deoxygenation (HHb), associated kinetics (τ), and energy system contributions. Eleven men (24±3 years) completed two trials of three cycling protocols: an 8 min continuous protocol (CONT) and two, 8 min intermittent exercise protocols with work-to-rest periods of 25 s-to-3 s (25INT) and 10 s-to-3 s (10INT). Each protocol began with a step-transition from a 20 W baseline to a power output (PO) of 60% between lactate threshold and maximal V̇O2p (Δ60)...
March 23, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28335350/shape-and-charge-of-gold-nanomaterials-influence-survivorship-oxidative-stress-and-moulting-of-daphnia-magna
#12
Fatima Nasser, Adam Davis, Eugenia Valsami-Jones, Iseult Lynch
Engineered nanomaterials (ENMs) are materials with at least one dimension between 1-100 nm. The small size of ENMs results in a large surface area to volume ratio, giving ENMs novel characteristics that are not traditionally exhibited by larger bulk materials. Coupled with large surface area is an enormous capacity for surface functionalization of ENMs, e.g., with different ligands or surface changes, leading to an almost infinite array of variability of ENMs. Here we explore the effects of various shaped (spheres, rods) and charged (negative, positive) gold ENMs on Daphnia magna (D...
November 25, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334542/-an-assessment-of-vo2-kinetics-in-the-recovery-phase-of-cardiopulmonary-exercise-test-in-patients-with-heart-disease-importance-and-classification
#13
Leona Mífková, František Várnay, Pavel Homolka, Petr Dobšák
The article reviews the course of VO2 in the phase of recovery kinetics of oxygen uptake (VO2rec) cardiopulmonary exercise test. VO2rec kinetics cannot be completely defined using a single parameter. The article describes the three most frequently used methods: %VO2-REC2, T1/2 VO2rec and TC VO2, and provides detailed procedures of their analysis. The three aforementioned parameters are also at the heart of our classification of VO2rec. The method %VO2-REC2 is an essential one, in our view, since its prognostic significance is proven and it can be also easily applied only based on a data record of the cardiopulmonary exercise test...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28332113/the-critical-power-concept-applications-to-sports-performance-with-a-focus-on-intermittent-high-intensity-exercise
#14
REVIEW
Andrew M Jones, Anni Vanhatalo
The curvilinear relationship between power output and the time for which it can be sustained is a fundamental and well-known feature of high-intensity exercise performance. This relationship 'levels off' at a 'critical power' (CP) that separates power outputs that can be sustained with stable values of, for example, muscle phosphocreatine, blood lactate, and pulmonary oxygen uptake ([Formula: see text]), from power outputs where these variables change continuously with time until their respective minimum and maximum values are reached and exercise intolerance occurs...
March 22, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28330316/phytotoxicity-and-oxidative-stress-perspective-of-two-selected-nanoparticles-in-brassica-juncea
#15
Sunita Rao, Gyan Singh Shekhawat
This study elaborates the consequences of oxidative stress caused by copper oxide (CuO) and titanium dioxide (TiO2) nanoparticles (NPs) in Brassica juncea. Effect of these two NPs on plant physiology, reactive oxygen scavenging enzyme system (ascorbate peroxidase, catalase, superoxide dismutase), proline content and lipid peroxidation has been estimated in leaves as well as root tissues. Bioaccumulation of NPs has also been evaluated in the current study and the interrelated cascade of the enzymatic system with H2O2 production was identified...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329109/impact-of-early-fontan-completion-on-postoperative-outcomes-in-patients-with-a-functional-single-ventricle%C3%A2
#16
Masamichi Ono, Melchior Burri, Julie Cleuziou, Jelena Pabst von Ohain, Elisabeth Beran, Martina Strbad, Alfred Hager, Jürgen Hörer, Christian Schreiber, Rüdiger Lange
OBJECTIVES: Our aim was to evaluate whether early timing of total cavopulmonary connection (TCPC) affects postoperative outcomes. METHODS: Of 460 consecutive TCPC patients, 51 (11.1%) underwent TCPC ≤ 18 months of age (group A), and 409 patients >18 months of age (group B). We compared the clinical outcomes and exercise capacity between groups. RESULTS: Median age at TCPC was 1.4 (interquartile ranges: 1.3-1.5) years in group A and 2...
February 23, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28327716/chemo-photodynamic-combined-gene-therapy-and-dual-modal-cancer-imaging-achieved-by-ph-responsive-alginate-chitosan-multilayer-modified-magnetic-mesoporous-silica-nanocomposites
#17
Hong Yang, Yin Chen, Zhongyuan Chen, Yue Geng, Xiaoxue Xie, Xue Shen, Tingting Li, Shun Li, Chunhui Wu, Yiyao Liu
Multifunctional theranostics have offered some interesting new opportunities for cancer therapy and diagnosis in the last decade. Herein, magnetic mesoporous silica nanoparticles (M-MSNs) were designed and synthesized, then the photosensitizer chlorin e6 (Ce6) and antitumor drug doxorubicin (Dox) were adsorbed onto the M-MSNs. Biocompatible alginate/chitosan polyelectrolyte multilayers (PEM) were assembled on the M-MSNs to achieve a pH-responsive drug delivery system and adsorb P-gp shRNA for reversing the multidrug resistance...
March 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28326310/cardiopulmonary-response-during-whole-body-vibration-training-in-patients-with-severe-copd
#18
Rainer Gloeckl, Petra Richter, Sandra Winterkamp, Michael Pfeifer, Christoph Nell, Jeffrey W Christle, Klaus Kenn
Several studies in patients with chronic obstructive pulmonary disease (COPD) have shown that whole-body vibration training (WBVT) has beneficial effects on exercise capacity. However, the acute cardiopulmonary demand during WBVT remains unknown and was therefore investigated in this study. Ten patients with severe COPD (forced expiratory volume in 1 s: 38±8% predicted) were examined on two consecutive days. On day one, symptom-limited cardiopulmonary exercise testing was performed on a cycle ergometer. The next day, six bouts of repeated squat exercises were performed in random order for one, two or three minutes either with or without WBVT while metabolic demands were simultaneously measured...
January 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28323592/measuring-uptake-and-elimination-of-nitrogen-in-humans-at-different-ambient-pressures
#19
Patrik Sundblad, Oskar Frånberg, Christoph Siebenmann, Mikael Gennser
BACKGROUND: To measure nitrogen (N2) wash-out and uptake requires elaborate set-ups, especially when doing the measurements at increased or decreased ambient pressure. Here we present a transportable device for quantifying N2 turnover in humans which can be used at different ambient pressures. METHODS: A modified close-circuit electronic rebreather was used to assess N2 turnover. Changes in N2 volume within the rebreathing circuit, reflecting N2 uptake or washout, were derived from the continuously monitored total system volume and the calculated volumes of oxygen and water vapor...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28323203/the-association-between-cardiorespiratory-fitness-and-pulmonary-diffusing-capacity
#20
Gerald S Zavorsky, James M Smoliga
Pulmonary diffusing capacity for nitric oxide (DL,NO) and carbon monoxide (DL,CO) measured at rest (mL/min/mmHg) is strongly associated with aerobic capacity (cardiorespiratory fitness or peak oxygen uptake, VO2peak) measured in L/min. Data from healthy, non-obese individuals from various studies (n=121 males and 81 females) were combined to examine this association. Subjects that were above the upper limit of normal (ULN, 97.5th percentile for age and sex and height) for DL,NO and DLCO had a higher median VO2peak compared to subjects below the ULN (Above the ULN=4...
March 16, 2017: Respiratory Physiology & Neurobiology
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