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https://www.readbyqxmd.com/read/29667342/middle-down-characterization-of-the-cell-cycle-dependence-of-histone-h4-post-translational-modifications-and-proteoforms
#1
Tingting Jiang, Michael E Hoover, Matthew V Holt, Michael A Freitas, Alan G Marshall, Nicolas L Young
Post-translational modifications (PTMs) of histones are important epigenetic regulatory mechanisms that are often dysregulated in cancer. We employ middle-down proteomics to investigate the PTMs and proteoforms of histone H4 during cell cycle progression. We use pH gradient weak cation exchange-hydrophilic interaction liquid chromatography (WCX-HILIC) for on-line liquid chromatography-mass spectrometry analysis to separate and analyze the proteoforms of histone H4. This provides enhanced separation of proteoforms, including positional isomers, and simplifies downstream data analysis...
April 17, 2018: Proteomics
https://www.readbyqxmd.com/read/29665447/propensity-score-to-evaluate-prognosis-in-pregnancy-associated-breast-cancer-analysis-from-a-french-cancer-network
#2
Anne-Sophie Boudy, Iptissem Naoura, Lise Selleret, Sonia Zilberman, Joseph Gligorov, Sandrine Richard, Isabelle Thomassin-Naggara, Nathalie Chabbert-Buffet, Marcos Ballester, Sofiane Bendifallah, Emile Darai
PURPOSE: To compare the prognosis of pregnancy associated breast cancer occurring during pregnancy (BCP) to non-pregnancy associated breast cancers (non-BCP) in young women managed at a national expert center. METHODS: Retrospective cohort study of a prospective database using propensity score matching (PSM) analysis with known prognostic factors. RESULTS: We analyzed data of 49 patients with BCP and 104 with non-BCP diagnosed between 2002 and 2017 at Tenon University Hospital (Paris, France)...
April 14, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29663660/7-12-dimethylbenz-%C3%AE-anthracene-increases-cell-proliferation-and-invasion-through-induction-of-wnt-%C3%AE-catenin-signaling-and-emt-process
#3
Yeo-Jung Kwon, Dong-Jin Ye, Hyoung-Seok Baek, Young-Jin Chun
7,12-Dimethylbenz[α]anthracene (DMBA) is a hazardous component present in polluted environments. DMBA has been used as an experimental tool for in vivo tumor formation owing to its carcinogenic effects, but the detailed molecular mechanism of DMBA has not been fully established. To comprehend the carcinogenic mechanism of DMBA, we explored its effects in the breast cancer cell lines, MCF-7 and MDA-MB-231, and the cervical cancer cell line, HeLa. Cell viability assay and measurement of a proliferation marker showed that DMBA markedly increased cancer cell proliferation...
April 16, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29662617/premature-ovarian-aging-in-brca-carriers-a-prototype-of-systemic-precocious-aging
#4
Irit Ben-Aharon, Mattan Levi, David Margel, Rinat Yerushalmi, Shulamith Rizel, Shlomit Perry, Eran Sharon, Noa Hasky, Ronit Abir, Benny Fisch, Ana Tobar, Ruth Shalgi, Salomon Marcello Stemmer
Purpose: Though former evidence implies a correlation of breast cancer susceptibility gene ( BRCA ) mutation with reduced ovarian reserve, the data is yet inconsistent. Our aim was to investigate biomarkers of ovarian aging in a cohort of young healthy carriers of the BRCA mutation. We hypothesized that the role played by BRCA genes in aging pathways is not exclusive to the ovary. Experimental Design: Healthy female BRCA carriers, 40 years or younger and healthy male BRCA carriers, 50 years or younger, were enrolled in the study...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29658601/silencing-of-casein-kinase-2-inhibits-pkc%C3%A2-induced-cell-invasion-by-targeting-mmp%C3%A2-9-in-mcf%C3%A2-7-cells
#5
Jeong-Mi Kim, Eun-Mi Noh, Hyun-Kyung Song, Yong-Ouk You, Sung Hoo Jung, Jong-Suk Kim, Kang-Beom Kwon, Young-Rae Lee, Hyun Jo Youn
Casein kinase 2 (CK2) is a serine/threonine protein kinase that has been considered to represent an important factor in mammary tumorigenesis. Increased expression of matrix metalloproteinase‑9 (MMP‑9) via nuclear factor‑κB (NF‑κB) activation has been demonstrated to promote breast cancer cell invasion. In the present study, the involvement of CK2 in protein kinase C (PKC) induced cell invasion in MCF‑7 breast cancer cells was investigated as well as the underlying molecular mechanisms. The mRNA and protein levels of MMP‑9 in MCF‑7 cells were investigated using reverse transcription‑quantitative polymerase chain reaction, western blot analyses and a zymography assay...
April 13, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29657543/association-of-abo-and-rh-blood-groups-with-breast-cancer
#6
Sultan Ayoub Meo, Faryal Suraya, Badar Jamil, Fwziah Al Rouq, Anusha Sultan Meo, Kamran Sattar, Mohammad Javed Ansari, Saleh A Alasiri
Objectives: The aim of this study was to determine the association of "ABO" and "Rhesus" blood groups with incidence of breast cancer. Methods: In this study, we identified 70 research documents from data based search engines including "PubMed", "ISI-Web of Knowledge", "Embase" and "Google Scholar". The research papers were selected by using the primary key-terms including "ABO blood type", "Rhesus" blood type and "breast cancer"...
November 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29649266/preoperative-dynamic-breast-magnetic-resonance-imaging-kinetic-features-using-computer-aided-diagnosis-association-with-survival-outcome-and-tumor-aggressiveness-in-patients-with-invasive-breast-cancer
#7
Sang Yu Nam, Eun Sook Ko, Yaeji Lim, Boo-Kyung Han, Eun Young Ko, Ji Soo Choi, Jeong Eon Lee
OBJECTIVES: To evaluate whether preoperative breast dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging kinetic features, assessed using computer-aided diagnosis (CAD), can predict survival outcome and tumor aggressiveness in patients with invasive breast cancer. MATERIALS AND METHODS: Between March and December 2011, 301 women who underwent preoperative DCE MR imaging for invasive breast cancer, with CAD data, were identified. All MR images were retrospectively evaluated using a commercially available CAD system...
2018: PloS One
https://www.readbyqxmd.com/read/29644766/fear-of-recurrence-among-older-breast-ovarian-endometrial-and-colorectal-cancer-survivors-findings-from-the-whi-lilac-study
#8
Jessica L Krok-Schoen, Michelle J Naughton, Brittany M Bernardo, Gregory S Young, Electra D Paskett
OBJECTIVE: To examine the prevalence of and factors associated with fear of recurrence (FCR) following treatment for breast, ovarian, endometrial, and colorectal cancer among older women. METHODS: Participants were enrolled in the Women's Health Initiative WHI Life and Longevity After Cancer (LILAC) study. Descriptive statistics and multivariate logistic regression models were used to assess the association of demographic, clinical, and quality of life variables with survivors' FCR, dichotomized as <14 (low) or ≥14 (high) using the Cancer Worry Scale...
April 12, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29642776/the-pink-underside-the-commercialization-of-medical-risk-assessment-and-decision-making-tools-for-hereditary-breast-cancer-risk
#9
Sharlene Hesse-Biber, Bailey Flynn, Keeva Farrelly
The growth of the Internet since the millennium has opened up a myriad of opportunities for education, particularly in medicine. Although those looking for health care information used to have to turn to a face-to-face doctor's visit, an immense library of medical advice is now available at their fingertips. The BRCA genetic predispositions (mutations of the BRCA1 and BRCA2 breast cancer genes) which expose men and women to greater risk of breast, ovarian, and other cancers can be researched extensively online...
April 1, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29629029/reactive-oxygen-species-dependent-apoptosis-induction-by-water-extract-of-citrus-unshiu-peel-in-mda-mb-231-human-breast-carcinoma-cells
#10
Min Yeong Kim, Eun Ok Choi, Hyun HwangBo, Da He Kwon, Kyu Im Ahn, Hong Jae Kim, Seon Yeong Ji, Su-Hyun Hong, Jin-Woo Jeong, Gi Young Kim, Cheol Park, Yung Hyun Choi
BACKGROUND/OBJECTIVES: Although several recent studies have reported the anti-cancer effects of extracts or components of Citrus unshiu peel, which has been used for various purposes in traditional medicine, the molecular mechanisms for their effects remain unclear. In the present study, the anti-cancer activity of a water-soluble extract of C. unshiu peel (WECU) in MDA-MB-231 human breast carcinoma cells at the level of apoptosis induction was investigated. MATERIALS/METHODS: Cytotoxicity was evaluated using the MTT assay...
April 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29628988/identification-of-the-thioredoxin-like-2-autoantibody-as-a-specific-biomarker-for-triple-negative-breast-cancer
#11
Jee Min Chung, Yongsik Jung, Young Pil Kim, Jinsue Song, Soyeon Kim, Ji Young Kim, Mira Kwon, Jung Hyun Yoon, Myo-Deok Kim, Jun-Kyoung Lee, Da-Yoon Chung, Seo Yun Lee, Jooseong Kang, Ho Chul Kang
Triple-negative breast cancer (TNBC) has a higher risk of death within 5 years of being diagnosed than the other forms of breast cancer. It is the second leading cause of death due to cancer among women. Currently, however, no diagnostic blood-based biomarker exists to identify the early stages of TNBC. To address this point, we utilized a human protein microarray system to identify serum autoantibodies that showed different expression patterns between TNBC and normal serum samples, and identified five autoantibodies showing TNBC-specific expression...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29628985/clinical-characteristics-and-prognosis-associated-with-multiple-primary-cancers-in-breast-cancer-patients
#12
Bong Kyun Kim, Se Jeong Oh, Jeong-Yoon Song, Han-Byoel Lee, Min Ho Park, Yongsik Jung, Woo-Chan Park, Jina Lee, Woo Young Sun
Purpose: Breast cancer is one of the most common malignancies worldwide and the second most common cancer among Korean women. The prognosis of breast cancer is poor in patients with other primary cancers. However, there have been few clinical studies regarding this issue. Therefore, we analyzed the characteristics and prognosis of patients with breast cancer with multiple primary cancers (MPCs). Methods: Data from the Korean Breast Cancer Society Registry were analyzed...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29628982/endocrine-treatment-related-symptoms-and-patient-outcomes-in-breast-cancer-a-meta-analysis
#13
Tae-Kyung Yoo, Myoung-Jin Jang, Eunshin Lee, Hyeong-Gon Moon, Dong-Young Noh, Wonshik Han
Purpose: An association between endocrine treatment-related symptoms and breast cancer recurrence has been suggested previously; however, conflicting results have been reported. We performed a meta-analysis of published studies to clarify this relationship. Methods: We systematically searched PubMed, Embase, Scopus, and the Cochrane database for studies investigating the association between endocrine treatment-related symptoms and patient survival. Random-effects meta-analysis was conducted with recurrence rate as the primary outcome...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29628981/troglitazone-inhibits-matrix-metalloproteinase-9-expression-and-invasion-of-breast-cancer-cell-through-a-peroxisome-proliferator-activated-receptor-%C3%AE-dependent-mechanism
#14
On-Yu Hong, Hyun Jo Youn, Hye-Yeon Jang, Sung Hoo Jung, Eun-Mi Noh, Hee Suk Chae, Young-Ju Jeong, Won Kim, Cheorl-Ho Kim, Jong-Suk Kim
Purpose: Peroxisome proliferator-activated receptor γ (PPARγ) is involved in the pathology of numerous diseases including atherosclerosis, diabetes, obesity, and cancer. Matrix metalloproteinases (MMPs) play a significant role in tissue remodeling related to various processes such as morphogenesis, angiogenesis, tissue repair, invasion, and metastasis. We investigated the effects of PPARγ on MMP expression and invasion in breast cancer cells. Methods: MCF-7 cells were cultured and then cell viability was monitored in an MTT assay...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29627127/the-action-of-estrogens-and-progestogens-in-the-young-female-breast
#15
Irene Zolfaroli, Juan J Tarín, Antonio Cano
Evidence from different sources sustains a pro-oncogenic role of hormones, estrogens and progestogens, on the breast. The issue is of interest for young women, who are exposed to the hormonal changes imposed by the ovarian cycle and, often, take hormones with contraceptive purposes. Experimental and clinical studies show that both estrogens and progesterone are involved in mammary development during puberty and lactation, the changes being observed across mammalian species, including humans. Estrogen receptors, and more particularly the alpha isoform, participate in molecular processes of stem cells differentiation and epithelial proliferation through paracrine actions implicating growth factors...
March 28, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29626240/mammographic-density-changes-following-discontinuation-of-tamoxifen-in-premenopausal-women-with-oestrogen-receptor-positive-breast-cancer
#16
Won Hwa Kim, Nariya Cho, Young-Seon Kim, Ann Yi
OBJECTIVES: To evaluate the changes in mammographic density after tamoxifen discontinuation in premenopausal women with oestrogen receptor-positive breast cancers and the underlying factors METHODS: A total of 213 consecutive premenopausal women with breast cancer who received tamoxifen treatment after curative surgery and underwent three mammograms (baseline, after tamoxifen treatment, after tamoxifen discontinuation) were included. Changes in mammographic density after tamoxifen discontinuation were assessed qualitatively (decrease, no change, or increase) by two readers and measured quantitatively by semi-automated software...
April 6, 2018: European Radiology
https://www.readbyqxmd.com/read/29621874/psychosocial-health-of-disease-free-breast-cancer-survivors-compared-with-matched-non-cancer-controls
#17
Boyoung Park, Moo Hyun Lee, Sun-Young Kong, Eun Sook Lee
Purpose: The present study investigated the psychosocial health of disease-free breast cancer survivors who receive health examinations compared to matched non-cancer controls in a community setting. Materials and Methods: We used baseline data from the Health Examinee cohort, which is composed of subjects participating in health. The disease-free breast cancer survivors were defined as those who were ≥2 years from initial diagnosis of breast cancer who had completed treatment...
April 5, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29620998/breast-cancer-family-history-and-contralateral-breast-cancer-risk-in-young-women-an-update-from-the-women-s-environmental-cancer-and-radiation-epidemiology-study
#18
Anne S Reiner, Julia Sisti, Esther M John, Charles F Lynch, Jennifer D Brooks, Lene Mellemkjær, John D Boice, Julia A Knight, Patrick Concannon, Marinela Capanu, Marc Tischkowitz, Mark Robson, Xiaolin Liang, Meghan Woods, David V Conti, David Duggan, Roy Shore, Daniel O Stram, Duncan C Thomas, Kathleen E Malone, Leslie Bernstein, Jonine L Bernstein
Purpose The Women's Environmental Cancer and Radiation Epidemiology (WECARE) study demonstrated the importance of breast cancer family history on contralateral breast cancer (CBC) risk, even for noncarriers of deleterious BRCA1/2 mutations. With the completion of WECARE II, updated risk estimates are reported. Additional analyses that exclude women negative for deleterious mutations in ATM, CHEK2*1100delC, and PALB2 were performed. Patients and Methods The WECARE Study is a population-based case-control study that compared 1,521 CBC cases with 2,212 individually matched unilateral breast cancer (UBC) controls...
April 5, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29620997/fertility-preservation-in-patients-with-cancer-asco-clinical-practice-guideline-update
#19
Kutluk Oktay, Brittany E Harvey, Ann H Partridge, Gwendolyn P Quinn, Joyce Reinecke, Hugh S Taylor, W Hamish Wallace, Erica T Wang, Alison W Loren
Purpose To provide current recommendations about fertility preservation for adults and children with cancer. Methods A systematic review of the literature published from January 2013 to March 2017 was completed using PubMed and the Cochrane Library. An Update Panel reviewed the identified publications. Results There were 61 publications identified and reviewed. None of these publications prompted a significant change in the 2013 recommendations. Recommendations Health care providers should initiate the discussion on the possibility of infertility with patients with cancer treated during their reproductive years or with parents/guardians of children as early as possible...
April 5, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29618765/associations-between-genetic-polymorphisms-of-membrane-transporter-genes-and-prognosis-after-chemotherapy-meta-analysis-and-finding-from-seoul-breast-cancer-study-sebcs
#20
Ji-Eun Kim, Jaesung Choi, JooYong Park, Chulbum Park, Se Mi Lee, Seong Eun Park, Nan Song, Seokang Chung, Hyuna Sung, Wonshik Han, Jong Won Lee, Sue K Park, Mi Kyung Kim, Dong-Young Noh, Keun-Young Yoo, Daehee Kang, Ji-Yeob Choi
Membrane transporters can be major determinants of the pharmacokinetic profiles of anticancer drugs. The associations between genetic variations of ATP-binding cassette (ABC) and solute carrier (SLC) genes and cancer survival were investigated through a meta-analysis and an association study in the Seoul Breast Cancer Study (SEBCS). Including the SEBCS, the meta-analysis was conducted among 38 studies of genetic variations of transporters on various cancer survivors. The population of SEBCS consisted of 1338 breast cancer patients who had been treated with adjuvant chemotherapy...
April 4, 2018: Pharmacogenomics Journal
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