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https://www.readbyqxmd.com/read/27746054/measuring-common-responses-to-psychosis-assessing-the-psychometric-properties-of-a-new-measure
#1
Sarah Tully, Adrian Wells, Melissa Pyle, Jemma Hudson, Andrew Gumley, David Kingdon, Matthias Schwannauer, Douglas Turkington, Anthony P Morrison
Responses to psychotic experiences are central to cognitive models of psychosis. The current study aimed to develop and validate a self-report measure of common responses to the experience of psychosis. This measure is needed as cognitive and behavioural responses are implicated in the maintenance of psychosis, but there is currently no measure that comprehensively assesses these maintaining factors. The Measure of Common Responses to psychosis (MCR) was developed and utilised in a sample of 487 participants who met criteria for treatment-resistant schizophrenia...
October 13, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27496180/design-and-protocol-for-the-focusing-on-clozapine-unresponsive-symptoms-focus-trial-a-randomised-controlled-trial
#2
Melissa Pyle, John Norrie, Matthias Schwannauer, David Kingdon, Andrew Gumley, Douglas Turkington, Rory Byrne, Suzy Syrett, Graeme MacLennan, Robert Dudley, Hamish J McLeod, Helen Griffiths, Samantha Bowe, Thomas R E Barnes, Paul French, Paul Hutton, Linda Davies, Anthony P Morrison
BACKGROUND: For around a third of people with a diagnosis of schizophrenia, the condition proves to respond poorly to treatment with many typical and atypical antipsychotics. This is commonly referred to as treatment-resistant schizophrenia. Clozapine is the only antipsychotic with convincing efficacy for people whose symptoms are considered treatment-resistant to antipsychotic medication. However, 30-40 % of such conditions will have an insufficient response to the drug. Cognitive behavioural therapy has been shown to be an effective treatment for schizophrenia when delivered in combination with antipsychotic medication, with several meta-analyses showing robust support for this approach...
2016: BMC Psychiatry
https://www.readbyqxmd.com/read/25273290/the-promise-of-cognitive-behavior-therapy-for-treatment-of-severe-mental-disorders-a-review-of-recent-developments
#3
Michael E Thase, David Kingdon, Douglas Turkington
Cognitive behavior therapy (CBT), as exemplified by the model of psychotherapy developed and refined over the past 40 years by A.T. Beck and colleagues, is one of the treatments of first choice for ambulatory depressive and anxiety disorders. Over the past several decades, there have been vigorous efforts to adapt CBT for treatment of more severe mental disorders, including schizophrenia and the more chronic and/or treatment refractory mood disorders. These efforts have primarily studied CBT as an adjunctive therapy, i...
October 2014: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/25193976/a-randomized-controlled-trial-comparing-cognitive-behavior-therapy-cognitive-adaptation-training-their-combination-and-treatment-as-usual-in-chronic-schizophrenia
#4
RANDOMIZED CONTROLLED TRIAL
Dawn I Velligan, Sara Tai, David L Roberts, Natalie Maples-Aguilar, Matt Brown, Jim Mintz, Douglas Turkington
Following baseline assessment, 166 patients in medication maintenance at a community mental health center who were experiencing both persistent positive symptoms of schizophrenia and impairments in functioning were randomized to 1 of 4 treatments for 9 months: (1) Cognitive Behavior Therapy for psychosis (CBTp)-a therapy designed to identify and alter reasoning and appraisal biases that contribute to the formation and maintenance of positive symptoms, (2) Cognitive Adaptation Training (CAT)-a treatment using environmental supports including signs, alarms, checklists and the organization of belongings established at weekly home visits to compensate for impairments in cognitive functioning and improve everyday functional outcomes, (3) Multi-modal Cognitive treatment-a combination of CBTp and CAT, and (4) Treatment as Usual...
May 2015: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/24508320/cognitive-therapy-for-people-with-schizophrenia-spectrum-disorders-not-taking-antipsychotic-drugs-a-single-blind-randomised-controlled-trial
#5
RANDOMIZED CONTROLLED TRIAL
Anthony P Morrison, Douglas Turkington, Melissa Pyle, Helen Spencer, Alison Brabban, Graham Dunn, Tom Christodoulides, Rob Dudley, Nicola Chapman, Pauline Callcott, Tim Grace, Victoria Lumley, Laura Drage, Sarah Tully, Kerry Irving, Anna Cummings, Rory Byrne, Linda M Davies, Paul Hutton
BACKGROUND: Antipsychotic drugs are usually the first line of treatment for schizophrenia; however, many patients refuse or discontinue their pharmacological treatment. We aimed to establish whether cognitive therapy was effective in reducing psychiatric symptoms in people with schizophrenia spectrum disorders who had chosen not to take antipsychotic drugs. METHODS: We did a single-blind randomised controlled trial at two UK centres between Feb 15, 2010, and May 30, 2013...
April 19, 2014: Lancet
https://www.readbyqxmd.com/read/24467392/adapting-cognitive-behavioral-therapy-for-psychosis-for-case-managers-increasing-access-to-services-in-a-community-mental-health-agency
#6
Vicki L Montesano, Harry J Sivec, Mark R Munetz, Jeremy R Pelton, Douglas Turkington
OBJECTIVE: The purpose of this article is twofold: (a) to describe the adaptation of an evidence-based practice and, (b) using a dissemination framework, to describe the process of implementing the practice at a community mental health agency. METHOD: The authors describe the training concept and dissemination framework of implementing an emerging practice: high-yield cognitive behavioral techniques for psychosis, which is rooted in cognitive behavioral therapy...
March 2014: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/24375209/high-yield-cognitive-behavioral-techniques-for-psychosis-delivered-by-case-managers-to-their-clients-with-persistent-psychotic-symptoms-an-exploratory-trial
#7
Douglas Turkington, Mark Munetz, Jeremy Pelton, Vicki Montesano, Harry Sivec, Bina Nausheen, David Kingdon
Case managers spend more time with clients with schizophrenia than any other professional group does in most clinical settings in the United States. Cognitive behavioral therapy (CBT) adapted for individuals with persistent psychotic symptoms, referred to as CBT-p, has proven to be a useful intervention when given by expert therapists in randomized clinical trials. It is currently unknown whether techniques derived from CBT-p could be safely and effectively delivered by case managers in community mental health agencies...
January 2014: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/23842792/modulation-of-circulating-angiogenic-factors-and-tumor-biology-by-aerobic-training-in-breast-cancer-patients-receiving-neoadjuvant-chemotherapy
#8
Lee W Jones, Diane R Fels, Miranda West, Jason D Allen, Gloria Broadwater, William T Barry, Lee G Wilke, Elisabeth Masko, Pamela S Douglas, Rajesh C Dash, Thomas J Povsic, Jeffrey Peppercorn, P Kelly Marcom, Kimberly L Blackwell, Gretchen Kimmick, Timothy G Turkington, Mark W Dewhirst
Aerobic exercise training (AET) is an effective adjunct therapy to attenuate the adverse side-effects of adjuvant chemotherapy in women with early breast cancer. Whether AET interacts with the antitumor efficacy of chemotherapy has received scant attention. We carried out a pilot study to explore the effects of AET in combination with neoadjuvant doxorubicin-cyclophosphamide (AC+AET), relative to AC alone, on: (i) host physiology [exercise capacity (VO2 peak), brachial artery flow-mediated dilation (BA-FMD)], (ii) host-related circulating factors [circulating endothelial progenitor cells (CEP) cytokines and angiogenic factors (CAF)], and (iii) tumor phenotype [tumor blood flow ((15)O-water PET), tissue markers (hypoxia and proliferation), and gene expression] in 20 women with operable breast cancer...
September 2013: Cancer Prevention Research
https://www.readbyqxmd.com/read/22859572/antipsychotics-is-it-time-to-introduce-patient-choice
#9
EDITORIAL
Anthony P Morrison, Paul Hutton, David Shiers, Douglas Turkington
Evidence regarding overestimation of the efficacy of antipsychotics and underestimation of their toxicity, as well as emerging data regarding alternative treatment options, suggests it may be time to introduce patient choice and reconsider whether everyone who meets the criteria for a schizophrenia spectrum diagnosis requires antipsychotics in order to recover.
August 2012: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/22749622/reliability-and-validity-of-the-personal-and-social-performance-scale-in-patients-with-schizophrenia
#10
Beenish Nafees, Patricia van Hanswijck de Jonge, Donald Stull, Katie Pascoe, Martin Price, Amory Clarke, Douglas Turkington
OBJECTIVE: The construct validity and test-retest reliability of the Personal and Social Performance (PSP) scale were used to assess social functioning in a cohort of ethnically diverse UK patients with schizophrenia. METHODS: A total of 73 patients with schizophrenia took part in the study. At baseline, the PSP, two symptomatology scales and two other functioning scales were administered. A subset of the sample (N=40) took part in a retest where the Clinical Global Impression-Severity (CGI-S) and PSP scales were administered 8-10 days later...
September 2012: Schizophrenia Research
https://www.readbyqxmd.com/read/22209267/a-preliminary-exploration-of-predictors-of-outcome-and-cognitive-mechanisms-of-change-in-cognitive-behaviour-therapy-for-psychosis-in-people-not-taking-antipsychotic-medication
#11
Anthony P Morrison, Douglas Turkington, Melissa Wardle, Helen Spencer, Sarah Barratt, Robert Dudley, Alison Brabban, Paul Hutton
BACKGROUND: Cognitive behaviour therapy (CBT) has been shown to be effective in an open trial for people with psychotic disorders who have not been taking antipsychotic medication. There is little known about predictors of outcome in CBT for psychosis and even less about hypothesised mechanisms of change. METHOD: 20 participants with schizophrenia spectrum disorders received CBT in an exploratory trial. Our primary outcome was psychiatric symptoms measured using the PANSS...
February 2012: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/21969421/cognitive-therapy-for-negative-symptoms-of-schizophrenia
#12
EDITORIAL
Douglas Turkington, Anthony P Morrison
No abstract text is available yet for this article.
February 2012: Archives of General Psychiatry
https://www.readbyqxmd.com/read/21722053/a-pilot-study-exploring-the-contribution-of-working-memory-to-jumping-to-conclusions-in-people-with-first-episode-psychosis
#13
John Ormrod, Debra Shaftoe, Kate Cavanagh, Mark Freeston, Douglas Turkington, Jason Price, Robert Dudley
INTRODUCTION: People with delusional beliefs "jump to conclusions" (JTC). This finding is well replicated. However, there is only limited exploration of the factors that might lead a person to JTC. The aim of the present study was to explore the contribution of working memory processes (WM) and IQ to hasty decision making and to investigate the stability of this bias over time. METHODS: A single group cross-sectional design was utilised. The study was conducted in 2 phases: (1) an initial screening phase and (2) an experimental phase whereby we explored and tested hypotheses regarding the cognitive origins of the JTC bias...
2012: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/21384122/a-semi-structured-clinical-interview-for-psychosis-sub-groups-scips-development-and-psychometric-properties
#14
Yoshihiro Kinoshita, David Kingdon, Kuni Kinoshita, Sheeba Sarafudheen, Deepa Umadi, David Dayson, Lars Hansen, Shanaya Rathod, Richard B Ibbotson, Douglas Turkington, Toshi A Furukawa
BACKGROUND: Clinical sub-groups of schizophrenia, namely drug related, traumatic, anxiety and stress sensitivity sub-types, have been proposed for use in research, training and practice. They were developed on the basis of clinical observation but have not yet been used in research or clinical practice to any great extent. AIMS: To develop a semi-structured clinical interview for psychosis sub-groups (SCIPS) and determine the best diagnostic criteria with the highest inter-rater reliability, test-retest reliability and concurrent validity for sub-grouping patients with schizophrenia according to a newly developed classification scheme...
April 2012: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/21272275/-jumping-to-conclusions-in-first-episode-psychosis
#15
Robert Dudley, Debra Shaftoe, Kate Cavanagh, Helen Spencer, John Ormrod, Douglas Turkington, Mark Freeston
AIM: People with psychotic symptoms are reported to have a characteristic reasoning style in which they jump to conclusions (JTC). The aims of this research were threefold. The first was to establish how prevalent this style is in people with first-episode psychosis. The second was to examine the specificity of JTC to delusions. The third was to examine explanatory factors that may account for the JTC style. This was investigated by attempting to replicate, with a large sample, previous studies indicating that JTC is associated with specific psychotic and non-psychotic symptoms and processes...
February 2011: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/21109043/psychopathology-in-postinfarction-patients-implanted-with-cardioverter-defibrillators-for-secondary-prevention-a-cross-sectional-case-controlled-study
#16
Anthony P Redhead, Douglas Turkington, Sanjay Rao, Margaret M Tynan, John P Bourke
OBJECTIVE: To determine (1) the incidence of anxiety and depression in patients implanted with defibrillators for secondary arrhythmia protection after myocardial infarction; (2) the effect of comorbidity and receipt of shock therapy on psychosocial maladjustment. METHODS: Cross-sectional, one-off, questionnaire-based (HADS; MOS SF-36), case-controlled study of defibrillator recipients (n=100) from a 3-year implant period and three groups of matched controls [pacemaker (n=50), coronary intervention (n=50), atrial fibrillation (n=50)], sharing specific preselected previous health experiences...
December 2010: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/20029820/ageism-in-first-episode-psychosis
#17
Emma Mitford, Robert Reay, Kate McCabe, Roger Paxton, Douglas Turkington
OBJECTIVE: To consider the characteristics of first episode psychosis in older adults in a county in North East England. METHOD/DESIGN: The present study used a naturalistic design to compare individuals aged 65 years and over with those under 65, with a first episode psychosis. Data were collected on demographics, diagnosis at presentation and hospital admissions in the first year. RESULTS: Almost a quarter of all patients were aged 65 years or older...
November 2010: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/19661198/the-evolution-of-cognitive-behavior-therapy-for-schizophrenia-current-practice-and-recent-developments
#18
REVIEW
Sara Tai, Douglas Turkington
Cognitive behavior therapy (CBT) evolved from behavioral theory and developed to focus more on cognitive models that incorporated reappraisal of thinking errors and schema change strategies. This article will describe the key elements of CBT for schizophrenia and the current evidence of its efficacy and effectiveness. We conclude with a description of recent concepts that extend the theoretical basis of practice and expand the range of CBT strategies for use in schizophrenia. Mindfulness, meta-cognitive approaches, compassionate mind training, and method of levels are postulated as useful adjuncts for CBT with psychotic patients...
September 2009: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/19620602/multimodal-cognitive-therapy-combining-treatments-that-bypass-cognitive-deficits-and-deal-with-reasoning-and-appraisal-biases
#19
Dawn I Velligan, Meredith Draper, Donna Stutes, Natalie Maples, Jim Mintz, Sara Tai, Douglas Turkington
The process of recovery in schizophrenia involves resolving persistent symptoms, addressing cognitive impairments, and improving functional outcomes. Our research group has demonstrated the efficacy of cognitive adaptation training (CAT)--a home-based psychosocial treatment utilizing environmental supports such as medication containers, signs, checklists, and the organization of belongings to bypass deficits in cognitive functioning and cue and sequence adaptive behavior) for improving adherence to medications and functional outcomes in schizophrenia...
September 2009: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/19571248/predictors-of-outcome-in-brief-cognitive-behavior-therapy-for-schizophrenia
#20
COMPARATIVE STUDY
Alison Brabban, Sara Tai, Douglas Turkington
Antipsychotic medications, while effective, often leave patients with ongoing positive and negative symptoms of schizophrenia. Guidelines recommend using cognitive behavior therapy (CBT) with this group. Clearly, mental health professionals require training and supervision to deliver CBT-based interventions. This study tested which antipsychotic-resistant patients were most likely to respond to brief CBT delivered by psychiatric nurses. Staff were trained over 10 consecutive days with ongoing weekly supervision...
September 2009: Schizophrenia Bulletin
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