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Antipsychotics in geriatric

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https://www.readbyqxmd.com/read/28540050/effect-of-atypical-antipsychotics-on-body-weight-in-geriatric-psychiatric-inpatients
#1
Eugene Yh Yeung, Soojin Chun, Alan Douglass, Timothy E Lau
BACKGROUND: Studies suggest that antipsychotic-induced weight gain is not a great concern in the elderly population. This study investigated the weight change in elderly patients with various treatment duration and antipsychotics. Part 1 of the study was to determine whether atypical antipsychotics induced weight change in elderly patients. Part 2 was to determine whether certain atypical antipsychotics induced more weight change in elderly patients. METHODS: In Part 1, a retrospective chart review was done on 115 geriatric inpatients...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28465867/differences-in-antipsychotic-related-adverse-events-in-adult-pediatric-and-geriatric-populations
#2
Hersh Sagreiya, Yi-Ren Chen, Narmadan A Kumarasamy, Karthik Ponnusamy, Doris Chen, Amar K Das
In recent years, antipsychotic medications have increasingly been used in pediatric and geriatric populations, despite the fact that many of these drugs were approved based on clinical trials in adult patients only. Preliminary studies have shown that the "off-label" use of these drugs in pediatric and geriatric populations may result in adverse events not found in adults. In this study, we utilized the large-scale U.S. Food and Drug Administration (FDA) Adverse Events Reporting System (AERS) database to look at differences in adverse events from antipsychotics among adult, pediatric, and geriatric populations...
February 26, 2017: Curēus
https://www.readbyqxmd.com/read/28436193/association-between-using-medications-with-anticholinergic-properties-and-short-term-cognitive-decline-among-older-men-a-retrospective-cohort-study-in-taiwan
#3
Yi-Hui Wu, Chih-Jen Wang, Cheng-Hao Hung, Liang-Yu Chen, Ming-Hsien Lin, Pei-Ning Wang, Liang-Kung Chen
AIM: The use of anticholinergic drugs had been strongly linked to adverse health outcomes among older adults, especially in cognitive impairment or dementia. The present study aimed to evaluate the cognitive decline related to the use of anticholinergic drugs among older men living in the veterans' homes in Taiwan. METHODS: This retrospective cohort study was a substudy of The Longitudinal Older Veterans study. A total of 274 residents living in four Taiwan veterans' homes and receiving two consecutive Mini-Mental State Examinations within the interval of 6 months from January 2012 to December 2014 were enrolled in the present study...
April 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28436192/predictors-of-non-pharmacological-intervention-effect-on-cognitive-function-and-behavioral-and-psychological-symptoms-of-older-people-with-dementia
#4
Ting-Jung Hsu, Hui-Te Tsai, An-Chun Hwang, Liang-Yu Chen, Liang-Kung Chen
AIM: Our previous work showed that non-pharmacological interventions could effectively reduce the severity of behavioral and psychological symptoms of dementia (BPSD), while the factors influencing the effect of intervention were less explored. Therefore, the main purpose of the present study was to investigate the predictors of the non-pharmacological intervention effect for old veterans with dementia and BPSD. METHODS: A total of 141 old veterans with dementia living in two veterans' homes in northern Taiwan were recruited...
April 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28164113/nonpharmacological-interventions-targeted-at-delirium-risk-factors-delivered-by-trained-volunteers-medical-and-psychology-students-reduced-need-for-antipsychotic-medications-and-the-length-of-hospital-stay-in-aged-patients-admitted-to-an-acute-internal-medicine
#5
Stanislaw Gorski, Karolina Piotrowicz, Krzysztof Rewiuk, Monika Halicka, Weronika Kalwak, Paulina Rybak, Tomasz Grodzicki
Purpose. Effectiveness of nonpharmacological multicomponent prevention delivered by trained volunteers (medical and psychology students), targeted at delirium risk factors in geriatric inpatients, was assessed at an internal medicine ward in Poland. Patients and Methods. Participants were recruited to intervention and control groups at the internal medicine ward (inclusion criteria: age ≥ 75, acute medical condition, basic orientation, and logical contact on admission; exclusion criteria: life expectancy < 24 hours, surgical hospitalization, isolation due to infectious disease, and discharge to other medical wards)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28152179/central-nervous-system-medication-burden-and-serious-falls-in-older-nursing-home-residents
#6
Joseph T Hanlon, Xinhua Zhao, Jennifer G Naples, Sherrie L Aspinall, Subashan Perera, David A Nace, Nicholas G Castle, Susan L Greenspan, Carolyn T Thorpe
OBJECTIVES: To examine the association between CNS medication burden and serious falls in those with a recent fall history. DESIGN: Nested-case control study; cases matched to four controls by age, gender, and date. SETTING: US nursing homes. PARTICIPANTS: 5,556 residents age ≥65 with a recent fall history admitted to a nursing home between 1/1-9/30/2010 and followed until discharge, death, or December 31, 2010. MEASUREMENTS: Outcome was serious falls as per Medicare Part A and B ICD/CPT codes...
June 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28124100/-treatment-with-psychotropic-agents-in-patients-with-dementia-and-delirium-gap-between-guideline-recommendations-and-treatment-practice
#7
Walter Hewer, Christine Thomas
BACKGROUND AND OBJECTIVES: Psychiatric symptoms in dementia and delirium are associated with a substantially reduced quality of life of patients and their families and often challenging for professionals. Pharmacoepidemiological surveys have shown that, in particular, patients living in nursing homes receive prescriptions of psychotropic agents in significant higher frequency than recommended by current guidelines. This article focuses on a critical appraisal of this gap from the point of view of German healthcare services...
February 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28103856/relationship-between-the-presence-of-baccalaureate-educated-rns-and-quality-of-care-a-cross-sectional-study-in-dutch-long-term-care-facilities
#8
Ramona Backhaus, Erik van Rossum, Hilde Verbeek, Ruud J G Halfens, Frans E S Tan, Elizabeth Capezuti, Jan P H Hamers
BACKGROUND: Recent evidence suggests that an increase in baccalaureate-educated registered nurses (BRNs) leads to better quality of care in hospitals. For geriatric long-term care facilities such as nursing homes, this relationship is less clear. Most studies assessing the relationship between nurse staffing and quality of care in long-term care facilities are US-based, and only a few have focused on the unique contribution of registered nurses. In this study, we focus on BRNs, as they are expected to serve as role models and change agents, while little is known about their unique contribution to quality of care in long-term care facilities...
January 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28088727/representativeness-of-clinical-pet-study-participants-with-schizophrenia-a-systematic-review
#9
So Kirino, Takefumi Suzuki, Hiroyoshi Takeuchi, Masaru Mimura, Hiroyuki Uchida
While positron emission tomography (PET) studies have provided invaluable data on antipsychotic effects, selection bias remains a serious concern. A systematic review of PET studies that measured dopamine D2 receptor blockade with antipsychotics was conducted to examine their inclusion/exclusion criteria, using PubMed, EMBASE, and ClinicalTrials.gov (last search, September 2016). PET studies were included if they measured D2 receptor occupancy in patients with schizophrenia and included introduction of antipsychotic treatment or antipsychotic regimen change in a systematic manner...
May 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27891571/high-risk-medications-in-hospitalized-elderly-adults-are-we-making-it-easy-to-do-the-wrong-thing
#10
Nina L Blachman, Rosanne M Leipzig, Madhu Mazumdar, Jashvant Poeran
OBJECTIVES: To examine dosages of high-risk medications administered to elderly adults who fall in the hospital and to determine whether electronic default doses are appropriate for elderly adults. DESIGN: Retrospective. SETTING: Large urban academic hospital. PARTICIPANTS: Individuals aged 65 and older experiencing a fall. MEASUREMENTS: Prescribed daily dosages and use of high-risk medications (opiates, benzodiazepines, benzodiazepine-receptor agonists (BRAs), sleep medications, muscle relaxants, antipsychotics) administered within 24 hours before a fall were ascertained and compared with published recommended dosages for older adults and the hospital's electronic medical record (EMR) default doses for these drugs...
November 28, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27862784/does-being-assisted-by-care-workers-affect-antipsychotics-prescription-among-older-people-discharged-from-hospital
#11
Mirko Di Rosa, Paolo Fabbietti, Andrea Corsonello, Sergio Fusco, Federica Sganga, Stefano Volpato, Carmelinda Ruggiero, Graziano Onder, Fabrizia Lattanzio
AIM: Several factors can affect antipsychotic prescriptions, among which, caregivers. However, whether being assisted by a care worker might increase the rate of antipsychotic prescriptions at discharge from acute care hospital has not been previously investigated. We aimed to investigate whether being assisted by a care worker is associated with increased use of antipsychotics among older patients discharged from acute care hospitals. METHODS: The present series consisted of 928 patients not taking antipsychotics at admission in seven acute care wards of geriatric medicine in Italy (mean age 80...
November 10, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27751669/review-of-safety-and-efficacy-of-sleep-medicines-in-older-adults
#12
REVIEW
Jennifer L Schroeck, James Ford, Erin L Conway, Kari E Kurtzhalts, Megan E Gee, Krista A Vollmer, Kari A Mergenhagen
PURPOSE: Insomnia is problematic for older adults. After behavioral modifications fail to show adequate response, pharmacologic options are used. The pharmacokinetics of agents used to treat insomnia may be altered. This review focuses on the safety and efficacy of medications used to treat insomnia. METHODS: A literature search of Medline, PubMed, and Embase was conducted (January 1966-June 2016). It included systematic reviews, randomized controlled trials, observational studies, and case series that had an emphasis on insomnia in an older population...
November 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27743677/-prescription-of-antipsychotics-in-elderly-patients-with-dementia-in-a-psychiatric-hospital-impact-of-recommendations-of-the-french-health-authority
#13
X Jégouzo, M Desbordes, S Delègue, G Le Vacon, M Patrick, S Mouchabac
OBJECTIVES: Behavioral and psychological symptoms have a high prevalence in dementia. They include mood disorders, psychotic disorders and behavioral disorders such as aggression or screaming. Despite a number of side effects and an increased mortality, antipsychotic drugs are widely prescribed for treatment of this disorder. In France, this increased risk of mortality led in 2009 to the adoption of guidelines concerning all antipsychotics. The guidelines propose a sensible use of antipsychotics after the establishment of non-pharmacological measures...
October 12, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27672315/atypical-antipsychotics-as-add-on-treatment-in-late-life-depression
#14
Sibel Cakir, Zeynep Senkal
BACKGROUND: Second-generation antipsychotics (SGAs) have been used in the augmentation of treatment-resistant depression. However, little is known about their effectiveness, tolerability, and adverse events in the treatment of late-life depression, which were the aim of this study. METHODS: The retrospective data of patients aged >65 years who had a major depressive episode with inadequate response to antidepressant treatment and had adjuvant SGA treatment were analyzed...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27506478/prevalence-of-potentially-inappropriate-prescribing-among-older-adults-a-comparison-of-the-beers-2012-and-screening-tool-of-older-person-s-prescriptions-criteria-version%C3%A2-2
#15
Gulistan Bahat, Ilker Bay, Asli Tufan, Fatih Tufan, Cihan Kilic, Mehmet Akif Karan
AIM: To date, there is no study comparing the Beers 2012 and Screening Tool of Older Person's Prescriptions (STOPP) version 2 criteria, nor reporting a comparison of the prevalence of potentially inappropriate Prescribing (PIM) with STOPP version 2. We aimed to evaluate the prescriptions of patients admitted to a geriatric outpatient clinic with these tools, and to document the factors related to PIM use. METHODS: Older patients (aged ≥65 years) admitted to the outpatient clinic of a university hospital were retrospectively evaluated for PIM with Beers 2012 and STOPP version 2 criteria...
August 10, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27430902/-delirium-day-a-nationwide-point-prevalence-study-of-delirium-in-older-hospitalized-patients-using-an-easy-standardized-diagnostic-tool
#16
MULTICENTER STUDY
Giuseppe Bellelli, Alessandro Morandi, Simona G Di Santo, Andrea Mazzone, Antonio Cherubini, Enrico Mossello, Mario Bo, Angelo Bianchetti, Renzo Rozzini, Ermellina Zanetti, Massimo Musicco, Alberto Ferrari, Nicola Ferrara, Marco Trabucchi
BACKGROUND: To date, delirium prevalence in adult acute hospital populations has been estimated generally from pooled findings of single-center studies and/or among specific patient populations. Furthermore, the number of participants in these studies has not exceeded a few hundred. To overcome these limitations, we have determined, in a multicenter study, the prevalence of delirium over a single day among a large population of patients admitted to acute and rehabilitation hospital wards in Italy...
July 18, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27355332/melatonin-based-therapies-for-delirium-and-dementia
#17
Kannayiram Alagiakrishnan
Melatonin levels have been shown to decline with aging. Melatonin and its analogs in addition to their effect on sleep promotion, has been shown to have multiple pleiotropic effects. It can also help with neuroprotection through different mechanisms. Evidence in animal and human studies suggests that low levels of melatonin have been linked to delirium, mild cognitive impairment, dementia, and with certain behavioral problems. Recent clinical trials have showed that both melatonin and its analogs may be useful in the prevention, treatment of delirium, and the management of dementia...
May 2016: Discovery Medicine
https://www.readbyqxmd.com/read/27294270/-clinical-diagnosis-and-drug-therapy-of-elderly-patients-with-schizophrenia-a-restrospective-analysis-of-data-in-a-department-of-old-age-psychiatry
#18
Christian Jagsch, Gabriele Dietmaier, Maximilian Jagsch, Martin Kurz
BACKGROUND: The objective of this study was to survey the consistency of the clinical diagnostics and the psychopharmacological treatment of schizophrenia and delusional disorders suffered by older persons. A further aspect was to record significant clinical differences and also similarities between the patient groups in care, matching with the criteria of ICD 10 for schizophrenia (F20), persistent delusional disorders (F22) and schizoaffective disorder (F25). METHODS: Retrospective analysis with reference to the manually and electronically recorded patient medical records of an acute case care ward for geriatric psychiatry and psychotherapy...
June 2016: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/27255830/medications-associated-with-geriatric-syndromes-and-their-prevalence-in-older-hospitalized-adults-discharged-to-skilled-nursing-facilities
#19
Avantika A Saraf, Alec W Petersen, Sandra F Simmons, John F Schnelle, Susan P Bell, Sunil Kripalani, Amy P Myers, Amanda S Mixon, Emily A Long, J Mary Lou Jacobsen, Eduard E Vasilevskis
BACKGROUND: More than half of the hospitalized older adults discharged to skilled nursing facilities (SNFs) have more than 3 geriatric syndromes. Pharmacotherapy may be contributing to geriatric syndromes in this population. OBJECTIVES: Develop a list of medications associated with geriatric syndromes and describe their prevalence in patients discharged from acute care to SNFs. DESIGN: Literature review and multidisciplinary expert panel discussion, followed by cross-sectional analysis...
October 2016: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/27198080/does-admission-to-a-specialist-geriatric-medicine-ward-lead-to-improvements-in-aspects-of-acute-medical-care-for-older-patients-with-dementia
#20
Robert Briggs, Emma O'Shea, Ana de Siún, Desmond O'Neill, Paul Gallagher, Suzanne Timmons, Sean Kennelly
OBJECTIVE: The objective of this study is to clarify if admission to a specialist geriatric medicine ward leads to improvements in aspects of acute medical care for patients with dementia. METHODS: We analysed combined data involving 900 patients from the Irish and Northern Irish audits of dementia care. Data on baseline demographics, admission outcomes, clinical aspects of care, multidisciplinary assessment and discharge planning processes were collected. RESULTS: Less than one-fifth of patients received their inpatient care on a specialist geriatric medicine ward...
June 2017: International Journal of Geriatric Psychiatry
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