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Pesticide exposure

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https://www.readbyqxmd.com/read/27925275/nanoparticle-ag-co-exposure-reduces-the-accumulation-of-weathered-persistent-pesticides-by-earthworms
#1
Arnab Mukherjee, Joseph Hawthorne, Jason C White, Jason W Kelsey
Although the use of engineered nanomaterials continues to increase, an understanding of how these materials interact with co-existing contaminants in the environment is largely unknown. Here, the effect of Ag in bulk, ionic, and nanoparticle (NP; bare and polyvinyl pyrrolidone coated) form at 3 concentrations (0, 500, 1000, 2000 mg/kg; ion at 69, 138, 276 mg/kg) on the accumulation of field weathered chlordane and dichlorodiphenyldichloroethylene + metabolites (DDX) by Eisenia fetida (earthworm) was investigated...
December 7, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27925273/biochemical-response-of-the-africanized-honeybee-exposed-to-fipronil
#2
Thaisa C Roat, Stephan M Carvalho, Mário S Palma, Osmar Malaspina
Bees are recognized worldwide for their social, economic, and environmental value; however, they have been seriously threatened in recent decades by diseases and by high levels of pesticide use. The susceptibility of bees to insecticides makes them an important terrestrial model for assessing environmental quality, and various biomarkers have been developed for these assessments. The present study aimed to evaluate the activity of the enzymes acetylcholinesterase (AChE), carboxylesterase (CaE), and glutathione S-transferase (GST) in Africanized honeybees exposed to fipronil...
December 7, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27924835/longitudinal-study-of-pesticide-residue-levels-in-human-milk-from-western-australia-during-12-months-of-lactation-exposure-assessment-for-infants
#3
Jian Du, Zoya Gridneva, Melvin C L Gay, Ching T Lai, Robert D Trengove, Peter E Hartmann, Donna T Geddes
The presence of pesticides in human milk (HM) is of great concern due to the potential health effects for the breastfed infant. To determine the relationships between HM pesticides and infant growth and development, a longitudinal study was conducted. HM samples (n = 99) from 16 mothers were collected at 2, 5, 9 and 12 months of lactation. A validated QuEChERS method and Gas chromatography-tandem mass spectrometry (GC-MS/MS) were used for the analysis of 88 pesticides in HM. Only p,p'-DDE, p,p'-DDT and β-HCH were detected with a mean concentration (±SD) of 52...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917368/sex-steroid-hormone-single-nucleotide-polymorphisms-pesticide-use-and-the-risk-of-prostate-cancer-a-nested-case-control-study-within-the-agricultural-health-study
#4
Carol H Christensen, Kathryn Hughes Barry, Gabriella Andreotti, Michael C R Alavanja, Michael B Cook, Scott P Kelly, Laurie A Burdett, Meredith Yeager, Laura E Beane Freeman, Sonja I Berndt, Stella Koutros
Experimental and epidemiologic investigations suggest that certain pesticides may alter sex steroid hormone synthesis, metabolism or regulation, and the risk of hormone-related cancers. Here, we evaluated whether single-nucleotide polymorphisms (SNPs) involved in hormone homeostasis alter the effect of pesticide exposure on prostate cancer risk. We evaluated pesticide-SNP interactions between 39 pesticides and SNPs with respect to prostate cancer among 776 cases and 1,444 controls nested in the Agricultural Health Study cohort...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27917277/movento-influences-development-of-granulosa-cells-and-ovarian-follicles-and-foxo1-and-vnn1-gene-expression-in-balb-c-mice
#5
Sakineh Kaboli Kafshgiri, Kazem Parivar, Javad Baharara, Mohammad Amin Kerachian, Nasim Hayati Roodbari
OBJECTIVES: Pesticides has wide range of infertility in female reproductive. This study was done to evaluate the effect of movento pesticide on development of granulosa cells and ovarian follicles and FoxO1 and Vnn1 gene expression in BALB/c mice. MATERIALS AND METHODS: In this study 40 healthy BALB/c mice 5-6 weeks age were used. Animals were randomly allocated into four groups. Control (without any intervention), three experimental groups received 25, 50 and 100 mg/kg movento dissolved in PBS by gavage for 21 days...
November 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27914323/quantitative-farm-to-fork-human-norovirus-exposure-assessment-of-individually-quick-frozen-raspberries-and-raspberry-puree
#6
L Jacxsens, A Stals, A De Keuckelaere, B Deliens, A Rajkovic, M Uyttendaele
A quantitative human norovirus (NoV) exposure model describing transmission of NoV during pre-harvest, harvest and further processing of soft red fruits exemplified by raspberries is presented. The outcomes of the model demonstrate the presence of NoV in raspberry puree or individual quick frozen (IQF) raspberry fruits and were generated by Monte Carlo simulations by combining GoldSim® and @Risk® software. Input data were collected from scientific literature, observational studies and assumptions. NoV contamination of soft red fruits is assumed to take place at farms by application of contaminated water for pesticides dilution or by berries' pickers shedding NoV...
November 21, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27913071/determination-and-validation-of-an-aquatic-maximum-acceptable-concentration-environmental-quality-standard-mac-eqs-value-for-the-agricultural-fungicide-azoxystrobin
#7
Elsa Teresa Rodrigues, Miguel Ângelo Pardal, Cristiano Gante, João Loureiro, Isabel Lopes
The main goal of the present study was to determine and validate an aquatic Maximum Acceptable Concentration-Environmental Quality Standard (MAC-EQS) value for the agricultural fungicide azoxystrobin (AZX). Assessment factors were applied to short-term toxicity data using the lowest EC50 and after the Species Sensitivity Distribution (SSD) method. Both ways of EQS generation were applied to a freshwater toxicity dataset for AZX based on available data, and to marine toxicity datasets for AZX and Ortiva(®) (a commercial formulation of AZX) obtained by the present study...
November 29, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27908721/stress-response-in-honeybees-is-associated-with-changes-in-task-related-physiology-and-energetic-metabolism
#8
Célia Bordier, Séverine Suchail, Maryline Pioz, Jean Marc Devaud, Claude Collet, Mercedes Charreton, Yves Le Conte, Cédric Alaux
In a rapidly changing environment, honeybee colonies are increasingly exposed to diverse sources of stress (e.g., new parasites, pesticides, climate warming), which represent a challenge to individual and social homeostasis. However, bee physiological responses to stress remain poorly understood. We therefore exposed bees specialised in different tasks (nurses, guards and foragers) to ancient (immune and heat stress) or historically more recent sources of stress (pesticides), and we determined changes in the expression of genes linked to behavioural maturation (vitellogenin - vg and juvenile hormone esterase - jhe) as well as in energetic metabolism (glycogen level, expression level of the receptor to the adipokinetic hormone - akhr, and endothermic performance)...
November 28, 2016: Journal of Insect Physiology
https://www.readbyqxmd.com/read/27908700/sex-dependent-effects-of-developmental-exposure-to-different-pesticides-on-spatial-learning-the-role-of-induced-neuroinflammation-in-the-hippocampus
#9
Belén Gómez-Giménez, Marta Llansola, Vicente Hernández-Rabaza, Andrea Cabrera-Pastor, Michele Malaguarnera, Ana Agusti, Vicente Felipo
The use of pesticides has been associated with impaired neurodevelopment in children. The aims of this work were to assess: 1) the effects on spatial learning of developmental exposure to pesticides 2) if the effects are sex-dependent and 3) if hippocampal neuroinflammation is associated with the impairment of spatial learning. We analyzed the effects of developmental exposure to four pesticides: chlorpyrifos, carbaryl, endosulfan and cypermethrin. Exposure was from gestational day 7 to post-natal day 21 and spatial learning and memory was assessed when the rats were young adults...
November 29, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27908456/wastewater-based-epidemiology-to-assess-human-exposure-to-pyrethroid-pesticides
#10
Nikolaos I Rousis, Ettore Zuccato, Sara Castiglioni
Pesticides are active substances with potentially adverse effects on human health, and therefore great effort is addressed to study the relation between their widespread use and the effects on humans. To track human exposure to pesticides, novel approaches are needed to give additional information on exposure at population level. In this study, a novel application of Wastewater-Based Epidemiology (WBE) was developed to measure the intake of pyrethroid pesticides in a population. Three human urinary metabolites of pyrethroids were selected and validated as biomarkers of exposure by evaluating their sources and stability in wastewater...
November 28, 2016: Environment International
https://www.readbyqxmd.com/read/27907095/phenotypic-plasticity-epigenetic-or-genetic-modifications-in-relation-to-the-duration-of-cd-exposure-within-a-microevolution-time-range-in-the-beet-armyworm
#11
Maria Augustyniak, Anna Płachetka-Bożek, Alina Kafel, Agnieszka Babczyńska, Monika Tarnawska, Agnieszka Janiak, Anna Loba, Marta Dziewięcka, Julia Karpeta-Kaczmarek, Agnieszka Zawisza-Raszka
In the case of the pests inhabiting metal polluted or fields where the use of pesticides is common, a natural selection of resistant individuals can occur. This may pose serious problems for humans, agriculture, as well as the economies of many countries. In this study, the hypothesis that multigenerational (120 generations) exposure to cadmium of a beet armyworm population could be a selecting factor toward a more efficient DNA protection was verified. The hemocytes of individuals from two culture strains (control and Cd-exposed) were treated with H2O2 (a DNA-damaging agent) or PBS (reference)...
2016: PloS One
https://www.readbyqxmd.com/read/27905861/sodium-bisulfite-pyrosequencing-revealed-that-developmental-exposure-to-environmental-contaminant-mixtures-does-not-affect-dna-methylation-of-dna-repeats-in-sprague-dawley-rats
#12
Daniel Desaulniers, Cathy Cummings-Lorbetskie, Nanqin Li, Gong-Hua Xiao, Leonora Marro, Nasrin Khan, Karen Leingartner
Hypomethylation of DNA repeats has been linked to diseases and cancer predisposition. Human studies suggest that higher blood concentrations of environmental contaminants (EC) correlate with levels of hypomethylation of DNA repeats in blood. The objective of this study was to examine the effect of in utero and/or lactational exposure to EC on the methylation of DNA repeats (LINE-1 and identifier element) in Sprague-Dawley rat pups at birth, at postnatal day (PND) 21, and in adulthood (PND78-86). From gestation day 0 to PND20, dams were exposed to a mixture "M" of polychlorinated biphenyls (PCB), pesticides, and methylmercury (MeHg), at 0...
December 1, 2016: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/27905518/pesticide-toxicogenomics-across-scales-in-vitro-transcriptome-predicts-mechanisms-and-outcomes-of-exposure-in-vivo
#13
Immacolata Porreca, Fulvio D'Angelo, Lucia De Franceschi, Alessandro Mattè, Michele Ceccarelli, Achille Iolascon, Alberto Zamò, Filomena Russo, Maria Ravo, Roberta Tarallo, Marzia Scarfò, Alessandro Weisz, Mario De Felice, Massimo Mallardo, Concetta Ambrosino
In vitro Omics analysis (i.e. transcriptome) is suggested to predict in vivo toxicity and adverse effects in humans, although the causal link between high-throughput data and effects in vivo is not easily established. Indeed, the chemical-organism interaction can involve processes, such as adaptation, not established in cell cultures. Starting from this consideration we investigate the transcriptomic response of immortalized thyrocytes to ethylenthiourea and chlorpyrifos. In vitro data revealed specific and common genes/mechanisms of toxicity, controlling the proliferation/survival of the thyrocytes and unrelated hematopoietic cell lineages...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905515/neonicotinoid-induced-impairment-of-odour-coding-in-the-honeybee
#14
Mara Andrione, Giorgio Vallortigara, Renzo Antolini, Albrecht Haase
Exposure to neonicotinoid pesticides is considered one of the possible causes of honeybee (Apis mellifera) population decline. At sublethal doses, these chemicals have been shown to negatively affect a number of behaviours, including performance of olfactory learning and memory, due to their interference with acetylcholine signalling in the mushroom bodies. Here we provide evidence that neonicotinoids can affect odour coding upstream of the mushroom bodies, in the first odour processing centres of the honeybee brain, i...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27898309/diverging-temporal-trends-of-human-exposure-to-bisphenols-and-plastizisers-such-as-phthalates-caused-by-substitution-of-legacy-edcs
#15
Irina Gyllenhammar, Anders Glynn, Bo A G Jönsson, Christian H Lindh, Per Ola Darnerud, Kettil Svensson, Sanna Lignell
Phthalates and phenolic substances were investigated in urine samples from first-time mothers in Uppsala, Sweden, collected between 2009 and 2014. These substances have a comparably fast metabolism and urinary metabolites are predominantly analysed. The main aim was to investigate if measures to decrease production and use of certain phthalates and bisphenol A (BPA) have resulted in decreased human exposure, and to determine if exposures to replacement chemicals have increased. Temporal trends were evaluated for metabolites (n=13) of seven phthalates, a phthalate replacer, four different bisphenols, triclosan, one organophosphate-based flame retardant, and for two pesticides...
November 26, 2016: Environmental Research
https://www.readbyqxmd.com/read/27898270/a-method-for-quantitative-risk-appraisal-for-pesticide-risk-assessments
#16
Roger C Cochran, John H Ross
Pesticide risk assessments are fraught with uncertainties that arise from the process of estimating exposure to and toxicity of chemicals. Regulatory agencies resolve those uncertainties in a health-protective (conservative) manner, typically acknowledging only inter- and intraspecies uncertainties quantitatively. Other uncertainties may be acknowledged qualitatively, but those safety factors (SF) are not enumerated. Quantitative risk appraisal may be used to enumerate the multiplicative SF generated by conservative assumptions regarding uncertainties...
November 29, 2016: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/27895594/larval-exposure-to-chlorpyrifos-affects-nutritional-physiology-and-induces-genotoxicity-in-silkworm-philosamia-ricini-lepidoptera-saturniidae
#17
Moni K Kalita, Kishor Haloi, Dipali Devi
Chlorpyrifos is a most widely used organophosphate insecticide because of its cost effectiveness and degradable nature. However, this pesticide enters and contaminates the environment either by direct application, spray drifts or crop run off and shows adverse effect on the non-targeted organisms. Philosamia ricini (eri silkworm), one of the most exploited, domesticated and commercialized non mulberry silkworm is known for mass production of eri silk. The silkworm larvae get exposed to pesticide residues on the leaves of food plants...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27894686/the-use-of-the-lymphocyte-cytokinesis-block-micronucleus-assay-for-monitoring-pesticide-exposed-populations
#18
REVIEW
Claudia Bolognesi, Nina Holland
Pesticides are widely used around the world, and hundreds of millions of people are exposed annually in occupational and environmental settings. Numerous studies have demonstrated relationships between pesticide exposure and increased risk of cancers, neurodegenerative and neurodevelopmental disorders, respiratory diseases and diabetes. Assessment of genotoxicity of pesticides and biomonitoring their effect in exposed populations is critical for a better regulation and protection, but it can be complicated because pesticides are often used as complex mixtures...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27891778/paternal-and-joint-parental-occupational-pesticide-exposure-and-spina-bifida-in-the-national-birth-defects-prevention-study-1997-to-2002
#19
Stacy M Pettigrew, Erin M Bell, Alissa R Van Zutphen, Carissa M Rocheleau, Gary M Shaw, Paul A Romitti, Andrew Olshan, Philip J Lupo, Aida Soim, Jennifer A Makelarski, Adrian M Michalski, Wayne Sanderson
BACKGROUND: Because of persistent concerns over the association between pesticides and spina bifida, we examined the role of paternal and combined parental occupational pesticide exposures in spina bifida in offspring using data from a large population-based study of birth defects. METHODS: Occupational information from fathers of 291 spina bifida cases and 2745 unaffected live born control infants with estimated dates of delivery from 1997 to 2002 were collected by means of maternal report...
November 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27890414/developmental-neurotoxicants-in-human-milk-comparison-of-levels-and-intakes-in-three-european-countries
#20
Eliška Čechová, Martin Scheringer, Marta Seifertová, Ondřej Mikeš, Kristýna Kroupová, Jan Kuta, Joan Forns, Merete Eggesbø, Ilona Quaak, Marijke de Cock, Margot van de Bor, Henrieta Patayová, Ľubica Palkovičová Murínová, Anton Kočan
Developmental neurotoxicants (DNTs), such as methylmercury (MeHg), polychlorinated biphenyls (PCBs) and selected organochlorine pesticides (OCPs), have gained increasing interest recently due to their possible relation to developmental disorders in children, which are increasing worldwide. We analyzed levels of 14 developmental neurotoxicants in human milk samples from Slovakia (n=37), the Netherlands (n=120) and Norway (n=388). Positive identification for most target analytes was >95% in all samples. In all three countries MeHg was measured for the first time in mother milk...
November 24, 2016: Science of the Total Environment
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