Michelle Elbert, Frank Neumann, Maximilian Kiefer, Konstantinos Christofyllakis, Benedikt Balensiefer, Igor Kos, Gabi Carbon, Dominic Kaddu-Mulindwa, Joerg Thomas Bittenbring, Natalie Fadle, Evi Regitz, Falko Fend, Irina Bonzheim, Lorenz Thurner, Moritz Bewarder
Primary vitreoretinal lymphoma (PVRL) is a rare subtype of DLBCL and can progress into primary central nervous system lymphoma (PCNSL). To investigate the role of chronic antigenic stimulation in PVRL, we cloned and expressed B-cell receptors (BCR) from PVRL patients and tested for binding against human auto-antigens. SEL1L3, a protein with multiple glycosylation sites, was identified as the BCR target in 3/20 PVRL cases. SEL1L3 induces proliferation and BCR pathway activation in aggressive lymphoma cell lines...
April 26, 2024: Scientific Reports