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https://www.readbyqxmd.com/read/28817733/changing-patterns-of-cataract-services-in-north-west-nigeria-2005-2016
#1
Nasiru Muhammad, Mohammed Dantani Adamu, Mpyet Caleb, Nuhu Mohammed Maishanu, Aliyu Mohammed Jabo, Muhammad Mansur Rabiu, Covadonga Bascaran, Sunday Isiyaku, Allen Foster
PURPOSE: This study was conducted to assess the impact of the eye care programme on cataract blindness and cataract surgical services in Sokoto, Nigeria over a 12 year period 2005-2016. METHODS: Data from the 2005 population based cross-sectional study of blindness in Sokoto state was re-analysed to obtain baseline estimates of the prevalence of cataract blindness and cataract surgical coverage for persons 50 years and over in Wurno health zone. A population based survey of a representative sample of persons 50 years and over in Wurno health zone was conducted in July 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28814824/cataract-surgery-in-patients-with-pseudoex-foliation-syndrome-current-updates
#2
REVIEW
Luigi Fontana, Marco Coassin, Alfonso Iovieno, Antonio Moramarco, Luca Cimino
Pseudoexfoliation is a ubiquitous syndrome of multifactorial origin affecting elderly people by increasing the risk of cataract and secondary glaucoma development. Despite modern techniques and technologies for cataract surgery, pseudoexfoliation syndrome represents a challenge for surgeons because of the increased weakness of the zonular apparatus and limited pupil dilation. Due to the inherent difficulties during surgery, the risk of vitreous loss in these patients is several times higher than in cataract patients without pseudoexfoliation...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28807880/-broad-spectrum-bactericidal-activity-of-a-new-bioactive-grafting-material-f18-against-clinically-important-bacterial-strains
#3
M T Souza, L A Campanini, C R Chinaglia, O Peitl, E D Zanotto, C W O Souza
Infection is the most relevant surgical complication in implant or grafting procedures. Osteomyelitis and other chronic conditions pose a constant challenge in the current practice of medicine. In this context, a grafting biomaterial that possesses antibacterial properties combined with bioactivity could have great clinical impact. Researchers at the Vitreous Materials Laboratory (LaMaV-UFSCar) recently developed a glass composition, F18, which presents an improved workability range combined with high bioactivity...
August 11, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28804665/management-of-traumatic-cataract-with-posterior-capsular-rupture-a-case-report-and-in-vitro-model-study
#4
Wenjuan Wan, Ke Hu, Yan Ji, Can Li
PURPOSE: To investigate the optimal strategy for surgical management of traumatic cataract with posterior capsular rupture. METHODS: We describe four cases of traumatic cataract with posterior capsular rupture and an in vitro model built to evaluate the optimal infusion pressure during surgery. RESULTS: All patients underwent cataract surgery. By using an anterior chamber maintainer to elevate infusion pressure, we safely performed cataract extraction without phacoemulsification...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28803326/short-term-results-of-endovascular-surgery-with-tissue-plasminogen-activator-injection-for-central-retinal-vein-occlusion
#5
Masaaki Ishida, Shinya Abe, Takuya Nakagawa, Atsushi Hayashi
PURPOSE: To examine the effects of retinal endovascular surgery (REVS) with tissue plasminogen activator injection into the retinal vein in central retinal vein occlusion (CRVO) eyes. METHODS: Sixteen consecutive CRVO patients with macular edema and decreased visual acuity who were referred to Toyama University Hospital between March 2014 and February 2016 were included in this study. Changes in visual acuity (VA) and central retinal thickness (CRT) were evaluated up to 6 months after REVS...
August 12, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28802308/vitreous-amyloidosis-with-autonomic-neuropathy-of-the-digestive-tract-associated-with-a-novel-transthyretin-p-gly87arg-variant-in-a-bangladeshi-patient-a-case-report
#6
Benjamin Terrier, Magali Colombat, Caroline Beugnet, Astrid Quéant, Jonathan London, Jean-Baptiste Daudin, Claire Le Jeunne, Luc Mouthon, Dominique Monnet, Cécile Cauquil, Catherine Lacroix, David Adams, Antoine Brézin, Sophie Valleix
BACKGROUND: Hereditary transthyretin amyloidosis is an autosomal dominant inherited disorder, first described in families with sensorimotor and autonomic neuropathy. Since its first description, more than 120 amyloidogenic transthyretin mutations have been reported with various geographic distributions and associated with a wide range of phenotypes involving the peripheral nerve, the heart, the gastrointestinal tract, the eyes, the central nervous system, or the kidneys. In some cases of transthyretin amyloidosis, the first clinical manifestation is vitreous opacity...
August 13, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28801333/valsalva-haemorrhagic-retinopathy-in-pregnancy-after-yoga
#7
Abdul Rahman El-Khayat
A 35-year-old pregnant Caucasian woman at 27 weeks gestation presented with sudden onset painless loss of vision and a large floater in her left eye while doing yoga. She was found to have a dense vitreous haemorrhage with a small preretinal haemorrhage. Ultrasound imaging confirmed the haemorrhage and showed no other retinal damage. She was diagnosed with valsalva haemorrhagic retinopathy and was treated conservatively. After 5 months of follow-up, this woman had had a normal delivery and her haemorrhages and vision loss had resolved...
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28801261/long-wavelength-red-light-produces-hyperopia-in-juvenile-and-adolescent-tree-shrews
#8
Timothy J Gawne, Alexander H Ward, Thomas T Norton
In infant tree shrews, exposure to narrow-band long-wavelength (red) light, that stimulates long-wavelength sensitive cones almost exclusively, slows axial elongation and produces hyperopia. We asked if red light produces hyperopia in juvenile and adolescent animals, ages when plus lenses are ineffective. Animals were raised in fluorescent colony lighting (100-300 lux) until they began 13 days of red-light treatment at 11 (n=5, "infant"), 35 (n=5, "juvenile") or 95 (n=5, "adolescent") days of visual experience (DVE)...
August 8, 2017: Vision Research
https://www.readbyqxmd.com/read/28800650/peptide-nucleic-acid-fluorescence-in-situ-hybridization-for-detection-of-staphylococci-from-endophthalmitis-isolates-a-proof-of-concept-study
#9
Nimesh Patel, Darlene Miller, Nidhi Relhan, Harry W Flynn
Purpose: Rapid identification of pathogens causing endophthalmitis may improve treatment outcomes through early administration of species-specific medication. The current study reports a new molecular application of peptide nucleic acid-fluorescence in situ hybridization (PNA-FISH) with Staphylococcus-specific molecular PNA probes for the potential rapid detection of common pathogens causing endophthalmitis. Methods: An experimental study was designed to evaluate the proof of concept at the microbiology laboratory of the Bascom Palmer Eye Institute...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28800647/effects-of-vitrectomy-and-lensectomy-on-older-rhesus-macaques-oxygen-distribution-antioxidant-status-and-aqueous-humor-dynamics
#10
Carla J Siegfried, Ying-Bo Shui, Baohe Tian, T Michael Nork, Gregg A Heatley, Paul L Kaufman
Purpose: The purpose of this study is to evaluate effects of vitrectomy (PPV) and lens extraction with intraocular lens implantation (PE/IOL) on molecular oxygen (pO2) distribution, aqueous humor antioxidant-oxidant balance, aqueous humor dynamics, and histopathologic changes in the trabecular meshwork (TM) in the older macaque monkey. Methods: Six rhesus monkeys underwent PPV followed by PE/IOL. pO2, outflow facility, and intraocular pressure (IOP) were measured...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28800017/atypical-form-of-retinopathy-of-prematurity-with-severe-fibrovascular-proliferation-in-the-optic-disk-region
#11
Tadashi Yokoi, Satoshi Katagiri, Miina Hiraoka, Yuri Nakayama, Katsuhiro Hosono, Yoshihiro Hotta, Sachiko Nishina, Noriyuki Azuma
PURPOSE: To describe severe fibrovascular proliferation that developed in the optic disk region in an atypical form of retinopathy of prematurity (ROP). METHODS: Retrospective observational case reports. RESULTS: Four patients (8 eyes) with ROP were included. Three patients were born very prematurely (24-25 weeks of gestational age; weight, 500-1,000 grams); 1 patient was born at 33 weeks of gestational age. Among all eight eyes of four patients who received prompt ROP screening and underwent laser photocoagulation, six eyes had atypical and severe fibrovascular proliferation mainly in the optic disk region; the other two eyes, including one eye with classic ROP and one eye with aggressive posterior ROP, did not have the atypical form...
August 9, 2017: Retina
https://www.readbyqxmd.com/read/28799563/management-of-giant-retinal-tears-with-vitrectomy-and-perfluorocarbon-liquid-postoperatively-as-a-short-term-tamponade
#12
M A Mikhail, G Mangioris, R M Best, S McGimpsey, W C Chan
PurposeThe purpose of this study was to study outcomes after using perfluorocarbon liquid (PFCL) as a short-term postoperative vitreous substitute in eyes with retinal detachment from giant retinal tears (GRTs).Patients and methodsA retrospective consecutive case series of patients with retinal detachment from GRT, who underwent vitrectomy using PFCL as short-term postoperative retinal tamponade. PFCL was left in the eye for a mean of 6.7 days (range 7-8 days) and then replaced with gas or silicone oil (SO)...
August 11, 2017: Eye
https://www.readbyqxmd.com/read/28796146/hole-door-sign-a-novel-intraoperative-optical-coherence-tomography-feature-predicting-macular-hole-closure
#13
Vinod Kumar, Bhupendra Yadav
PURPOSE: To describe a novel intraoperative finding during pars plana vitrectomy for macular hole using operating microscope-integrated spectral domain optical coherence tomography that predicts the closure of macular hole. METHODS: Twenty-five eyes of 25 patients with macular hole, who underwent 25-gauge pars plana vitrectomy over a period of 16 months at a tertiary eye care center by a single surgeon, were recruited in this retrospective interventional study. All eyes were assessed with intraoperative spectral domain optical coherence tomography before and after internal limiting membrane peeling...
August 8, 2017: Retina
https://www.readbyqxmd.com/read/28795351/advancements-in-understanding-immunogenicity-of-biotherapeutics-in-the-intraocular-space
#14
Eric Wakshull, Valerie Quarmby, Hanns-Christian Mahler, Hongwen Rivers, Dhananjay Jere, Meg Ramos, Piotr Szczesny, Karoline Bechtold-Peters, Sharmila Masli, Swati Gupta
Therapeutic breakthroughs in a number of retinal degenerative diseases have come about through the development of biotherapeutics administered directly into the eye. As a consequence of their use, we have gained more insight into the immune privileged status of the eye and the various considerations that development, manufacturing, and use of these drugs require. It has been observed that therapeutic proteins injected into the vitreous can elicit an immune response resulting in the production of anti-drug antibodies (ADAs) which can have clinical consequences...
August 9, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28794614/accuracy-of-b-scan-ultrasonography-in-acute-fundus-obscuring-vitreous-hemorrhage-using-a-standardized-scanning-protocol-and-a-dedicated-ophthalmic-ultrasonographer
#15
Maria T Sandinha, Ajay K Kotagiri, Rona I Owen, Caspar Geenen, David Hw Steel
PURPOSE: To assess the accuracy of B-scan ultrasound (U/S) in diagnosing cases of acute fundus obscuring vitreous hemorrhage (FOVH) using a standardized scan protocol and dedicated ophthalmic ultrasonographer. METHODS: Consecutive patients presenting with acute FOVH of unknown cause, between January 2013 and December 2014, were prospectively recruited. Patients underwent a scan performed by a dedicated ultrasonographer, utilizing a systematic scan sequence and using an ocular specific U/S device...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28791491/retinal-vegf-levels-correlate-with-ocular-circulation-measured-by-a-laser-speckle-micro-system-in-an-oxygen-induced-retinopathy-rat-model
#16
Tadashi Matsumoto, Yuta Saito, Takashi Itokawa, Tomoaki Shiba, Mari S Oba, Haruo Takahashi, Yuichi Hori
PURPOSE: We used a Laser speckle flowgraphy (LSFG)-micro system to examine the relationship between ocular blood flow and retinal vascular endothelial growth factor (VEGF) at retinopathy onset in oxygen-induced ischemic retinopathy (OIR) model rats. METHODS: Sixteen 50/10 OIR rats were compared with 17 control rats reared in room air. In postnatal day 14 (P14) and P18 rats, we measured and analyzed the left eye's mean blur rate (MBR) by setting a rubber band on the optic nerve head center, using the LSFG-Micro...
August 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28791473/59-eyes-with-endogenous-endophthalmitis-causes-outcomes-and-mortality-in-a-danish-population-between-2000-and-2016
#17
Søren Solborg Bjerrum, Morten la Cour
BACKGROUND: To study the epidemiology of patients with endogenous endophthalmitis in Denmark. MATERIAL AND METHODS: Retrospective and prospective case series of 59 eyes in patients with endogenous endophthalmitis in Denmark between 2000 and 2016. RESULTS: The age of the patients ranged from 28 to 90 years with a median of 66 years. Sixty-two percent of the eyes had a final VA (visual acuity) ≤ 0.1 while 8% had a final VA ≥ 1.0. Positive cultures were obtained in 51% of the cases from the blood and in 43% from the vitreous...
August 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28782485/a-low-concentration-of-tacrolimus-semifluorinated-alkane-sfa-eyedrop-suppresses-intraocular-inflammation-in-experimental-models-of-uveitis
#18
S De Majumdar, M Subinya, J Korward, A Pettigrew, D Scherer, H Xu
PURPOSE: Corticosteroids remain the mainstay therapy for uveitis, a major cause of blindness in the working age population. However, a substantial number of patients cannot benefit from the therapy due to steroids resistance or intolerance. Tacrolimus has been used to treat refractory uveitis through systemic administration. The aim of this study was to evaluate the therapeutic potential of 0.03% tacrolimus eyedrop in mouse models of uveitis. METHODS: 0.03% tacrolimus in perfluorobutylpentane (F4H5) (0...
August 7, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28781956/the-proteomic-profile-of-a-mouse-model-of-proliferative-vitreoretinopathy
#19
Bernadett Márkus, Zsuzsanna Pató, Zsolt Sarang, Réka Albert, József Tőzsér, Goran Petrovski, Éva Csősz
Proliferative vitreoretinopathy (PVR) develops as a complication of retinal detachment surgery and represents a devastating condition leading to serious vision loss. A good animal model that permits extensive functional studies and drug testing is crucial in finding better therapeutic modalities for PVR. A previously established mouse model, using dispase injection, was analyzed from the proteomic point of view, examining global protein profile changes by 2D electrophoresis, image analysis and HPLC-tandem mass spectrometry-based protein identification...
August 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28780616/the-analysis-of-posterior-segment-findings-in-term-and-premature-infants-using-retcam-images
#20
Huseyin Gursoy, Mustafa Deger Bilgec, Nazmiye Erol, Hikmet Basmak, Ertugrul Colak
OBJECTIVE: To analyze posterior segment findings in term and premature infants using the RetCam image database. METHODS: RetCam images taken of infants born between January 2012 and December 2015 were reviewed. Group 1 included infants with posterior segment findings other than retinopathy of prematurity (ROP). Group 2 included infants with mild-to-severe ROP. The baseline characteristics, anterior segment findings, and percentage of infants who received treatment were compared among the 2 groups...
August 5, 2017: International Ophthalmology
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