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https://www.readbyqxmd.com/read/28430329/ahmed-valves-vs-trabeculectomy-combined-with-pans-plana-vitrectomy-for-neovascular-glaucoma-with-vitreous-hemorrhage
#1
Menghua H Wang, Qiuming M Li, Hongtao T Dong, Shuqian Q Dong, Yang Li, Chunyan Y Zheng
PURPOSE: Vitreous hemorrhage is common in advanced neovascular glaucoma (NVG), which has poor visual prognosis. This study aimed to compare the efficacy of 23-G pars planar vitrectomy (PPV) combined with either Ahmed glaucoma valve (AGV) implantation or trabeculectomy after intravitreal ranibizumab (IVR) treatment for NVG with vitreous hemorrhage. METHODS: This retrospective, nonrandomized study included 33 eyes of 33 patients with NVG with vitreous hemorrhage. After IVR treatment for 3-7 days, 18 eyes underwent PPV + AGV (AGV group) and 15 underwent PPV + trabeculectomy (trabeculectomy group)...
April 14, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28430324/negative-staining-of-the-vitreous-with-the-use-of-vital-dyes
#2
Cesare Mariotti, Michele Nicolai, Simone Donati, Michele Reibaldi
PURPOSE: The vitreous cortex, epiretinal membrane (ERM), and inner limiting membrane (ILM) are transparent tissues and are thus difficult to visualize. Staining these structures can increase the efficiency of a nontraumatic removal. METHODS: The surgeon performs a partial core vitrectomy and induces a posterior vitreous detachment. The vital dye is then injected into the retrohyaloid space in balanced salt solution (BSS). The dyes used are TWIN (Alchimia srl, Padova, Italy), MembraneBlue-Dual (DORC International, Zuidland, the Netherlands), and Doubledyne (Alfa Intes, Casoria, Italy)...
April 13, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28430320/remnant-extraction-by-using-an-intraocular-lens-injector-with-essential-flow
#3
Momoko Yamakawa, Mami Kusaka, Shogo Yamada, Masayuki Akimoto
PURPOSE: To describe a new technique for remnant removal in cases of posterior capsular rupture during cataract surgery and Soemmering ring extraction during intraocular lens (IOL) removal. METHODS: An IOL injector, inserted into the anterior chamber, provides a new exit for residual lens fragments. Passive fluid flow, supplied by an anterior chamber maintainer or some ocular viscoelastic device (OVD) injection, delivers the residual fragments into a lumen of the injector in assistance with a second device such as a phaco-chopper and vitreous cutter...
April 5, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28429128/endophthalmitis-associated-with-purpureocillium-lilacinum-during-infliximab-treatment-for-surgically-induced-necrotizing-scleritis-successfully-treated-with-27-gauge-vitrectomy
#4
Masaaki Yoshida, Shunji Yokokura, Hiroshi Kunikata, Naoko Takada, Kazuichi Maruyama, Masahiro Toyokawa, Kazushi Kashio, Mitsuo Kaku, Toru Nakazawa
PURPOSE: To report a case of endophthalmitis associated with Purpureocillium lilacinum (P. lilacinum) during infliximab treatment for surgically induced necrotizing scleritis, successfully treated with 27-gauge vitrectomy. METHODS: A single case report. RESULTS: A 71-year-old man who had undergone immunosuppressive therapy, including infliximab, for surgically induced necrotizing scleritis (SINS) in his left eye complained of visual disturbance and eye pain in the eye...
April 20, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28428971/retinal-research-in-latin-america-how-did-we-get-here
#5
J Fernando Arevalo
Among the numerous contributions by the Pan-American Association of Ophthalmology (PAAO) to the improvement of ophthalmology in Latin America, it has played an invaluable role in the development of the retina and vitreous subspecialty in the region. The quality of the research published in Latin America demonstrates the development of the retina subspecialty at this region and also the worldwide collaboration pioneered by PAAO and the Pan-American Collaborative Retina Study Group (PACORES). We would suggest further academic relationship at the regional as well as international levels as well as funding research institutes to assist retinal researchers in the region since it is generally thought that there is frequently a lack of government funding at all levels, from patient education to support for health teams to tertiary health care centers...
2017: Medical Hypothesis, Discovery and Innovation in Ophthalmology
https://www.readbyqxmd.com/read/28428837/large-is-required-for-normal-astrocyte-migration-and-retinal-vasculature-development
#6
Min Zhou, Herui Wang, Hui Ren, Rui Jiang, Chi Zhang, Xiaohui Wu, Gezhi Xu
BACKGROUND: Persistent fetal vasculature (PFV) is a congenital developmental anomaly of the eye that accounts for about 5% of childhood blindness. The molecular mechanism of PFV remains unclear. As a glycosyltransferase of α-dystroglycan, LARGE mutations have been found in congenital muscular dystrophy patients with brain abnormalities. Spontaneous Large mutant mice displayed similar symptoms of human muscle-eye-brain disorders. However, the detailed roles of Large in ocular vasculature development still need to be uncovered...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28427074/enzymatic-vitreolysis-for-vitreomacular-traction-in-diabetic-retinopathy
#7
Stanislao Rizzo, Daniela Bacherini
Vitreomacular traction (VMT) is one of many possible factors involved in the etiology of diabetic macular edema (DME). Pharmacologic vitreoretinal separation is a potential alternative to vitrectomy for VMT in diabetic retinopathy. Small case series have been published on the use of enzymatic vitreolysis in tractional DME, and demonstrate that the enzymatic release of the posterior vitreous cortex is more likely following the injection of plasmin enzyme. Further prospective and randomized clinical trials are necessary to evaluate the clinical relevance of ocriplasmin for vitreomacular traction in diabetic retinopathy, and additional studies are needed to determine more accurately which patients might benefit most from this treatment and how often and at what concentration ocriplasmin should be administered...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28427073/surgical-management-and-techniques
#8
Marco Codenotti, Lorenzo Iuliano, Gisella Maestranzi
Technical advancements have substantially extended the indications for surgery in diabetic retinopathy (DR) during the last 40 years, from the traditional indications including non-clearing vitreous hemorrhage, traction retinal detachment (RD), and traction-rhegmatogenous RD, to epiretinal membrane (ERM), vitreomacular traction, diffuse macular edema, neovascular glaucoma, and anterior hyaloid fibrovascular proliferation. The goals of vitreoretinal surgery in DR are multiple: clearing media opacities, release of traction (anteroposterior and/or tangential), segmentation and/or removal of traction bands, peeling of ERMs, hemostasis, laser photocoagulation, and tamponade of retinal breaks with gas or silicone oil...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28427061/emerging-insights-into-pathogenesis
#9
Edoardo Midena, Elisabetta Pilotto
Diabetic retinopathy (DR) is a frequent complication of diabetes mellitus (DM). Persistent hyperglycemia leads to the activation of multiple cellular pathways involved in the pathogenesis of DR, resulting in increased inflammation, oxidative stress, and vascular dysfunction. DR has been considered a "chronic, low-grade inflammatory disease of the retina". However, an increasing body of evidence suggests that inflammation and neurodegeneration both occur in human diabetes even before the development of clinical signs of DR...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28426810/correction-mirnas-in-the-vitreous-humor-of-patients-affected-by-idiopathic-epiretinal-membrane-and-macular-hole
#10
Andrea Russo, Marco Ragusa, Cristina Barbagallo, Antonio Longo, Teresio Avitabile, Maurizio G Uva, Vincenza Bonfiglio, Mario D Toro, Rosario Caltabiano, Cesare Mariotti, Francesco Boscia, Mario R Romano, Cinzia Di Pietro, Davide Barbagallo, Michele Purrello, Michele Reibaldi
[This corrects the article DOI: 10.1371/journal.pone.0174297.].
2017: PloS One
https://www.readbyqxmd.com/read/28426418/first-report-on-molecular-evidence-of-tylodelphys-cerebralis-diplostomulum-cerebralis-chakrabarti-1968-digenea-diplostomidae-from-snakehead-fish-channa-punctata
#11
Anshu Chaudhary, Richa Tripathi, Shivi Gupta, Hridaya Shanker Singh
Freshwater snakehead fish, Channa punctata (Perciformes: Channidae) from Meerut (U.P.), India were screened for infection with metacercaria from the eye (vitreous humor) and brain (cranial cavity) and were analyzed by molecular methods using PCR and sequencing of the complete internal transcribed spacers (ITS1-5.8S-ITS2) of the ribosomal RNA gene. Recovered metacercariae from sites, vitreous humor and cranial cavity were previously diagnosed as Diplostomulum cerebralis Chakrabarti, 1968 on the basis of morphological characteristics...
June 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28425224/nanocarrier-mediated-retinal-drug-delivery-overcoming-ocular-barriers-to-treat-posterior-eye-diseases
#12
REVIEW
Rohit Bisht, Abhirup Mandal, Jagdish K Jaiswal, Ilva D Rupenthal
Effective drug delivery to the retina still remains a challenge due to ocular elimination mechanisms and complex barriers that selectively limit the entry of drugs into the eye. To overcome these barriers, frequent intravitreal injections are currently used to achieve high drug concentrations in vitreous and retina. However, these repetitive injections may result in several side effects. Recent advancements in the field of nanoparticle-based drug delivery could overcome some of these unmet needs and various preclinical studies conducted to date have demonstrated promising results of nanotherapies in the treatment of retinal diseases...
April 20, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28425102/fatal-overdose-of-gamma-hydroxybutyrate-acid-after-ingestion-of-1-4-butanediol
#13
Erwan Le Garff, Vadim Mesli, Raphael Cornez, Christophe Demarly, Gilles Tournel, Valery Hédouin
We report a case of fatal intoxication from 1,4-butanediol (1,4-BD), which was ingested by a young and "naïve" gamma-hydroxybutyrate (GHB) consumer during a party with the co-ingestion of alcohol, cannabis, and methylene-dioxy-methamphetamine. The following drug concentrations were found using gas chromatography coupled with mass spectrometry on autopsy samples and on a cup and a glass found at the scene: 20,350 mg/L (bottle) for 1,4-BD; 1020 mg/L (femoral blood), 3380 mg/L (cardiac blood), 47,280 mg/L (gastric content), and 570 mg/L (vitreous humor) for GHB...
April 20, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28422290/heroin-related-deaths-from-the-hennepin-county-medical-examiner-s-office-from-2004-through-2015
#14
Sara A Love, Jessica Lelinski, Julie Kloss, Owen Middleton, Fred S Apple
Over the past two decades, prescription and illicit opioid use has led to changes in public health policy to address the increasing number of opioid-related deaths. The purpose of this study was to review cases from Hennepin County Medical Examiner's Office between 2004 through 2015 where heroin was listed as a significant contributor or as the cause of death. We identified 322 heroin-related deaths, which were predominantly male (255; 79%). 6-Monoacetylmorphine (6-MAM) median (range) concentrations were as follows: blood (n = 7), 0...
April 19, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28421654/short-term-outcomes-of-small-incision-cataract-surgery-provided-by-a-regional-population-in-the-pacific
#15
Riyaz Bhikoo, Hans Vellara, Salome Lolokabaira, Neil Murray, Biu Sikivou, Charles McGhee
BACKGROUND: To describe patient demographics, visual and surgical outcomes of a cohort undergoing Small Incision Cataract Surgery (SICS) at a Pacific regional ophthalmic training facility. DESIGN: Prospective, longitudinal study conducted at the Pacific Eye Institute, Fiji. PARTICIPANTS: 156 patients underwent SICS. METHODS: Preoperatively, a complete ophthalmic examination, including pachymetry and macular Optical Coherence Tomography (OCT) performed by two independent investigators...
April 19, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28418609/real-time-measurement-of-needle-forces-and-acute-pressure-changes-during-intravitreal-injections
#16
Logan Christensen, Ashlee Cerda, Jeffrey L Olson
BACKGROUND: The purpose of this study was to use a physiological pressure transducer to measure real-time, continuous pressure changes in an ex-vivo study model of porcine eyes to record the amount of force needed for scleral penetration and to measure acute IOP rise during intravitreal injections. METHODS: A pressure transducer was inserted into the anterior chamber of 30 fresh porcine eyes and intraocular pressure was measured two seconds prior to intravitreal injection until two seconds after...
April 18, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28416927/cataract-surgery-and-possible-complications-in-patients-with-pseudoexfoliation-syndrome
#17
Gulsum Egemen Erkayhan, Semih Dogan
OBJECTIVE: The aim of this study was to evaluate the demographic characteristics and intraoperative complications of cataract surgery in patients with pseudoexfoliation syndrome (PEX). MATERIALS AND METHODS: Cases of 225 eyes (80 eyes with pseudoexfoliation and 145 eyes without pseudoexfoliation as the control group) that underwent phacoemulsification cataract surgery and IOL implantation at the Silifke State Hospital Ophthalmology Clinic between April 2011 and April 2013 were analysed retrospectively...
February 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28415600/the-value-of-mri-in-evaluating-the-efficacy-and-complications-with-the-treatment-of-intra-arterial-chemotherapy-for-retinoblastoma
#18
Shuxian Chen, Xunda Ji, Ming Liu, Zhengrong Xia, Hui Zheng, Qiufeng Yin, He Wang, Yuhua Li
Retinoblastoma is the most common intraocular malignant tumor of childhood. Intra-arterial chemotherapy (IAC) is a recently popularized technique used for the treatment of retinoblastoma, to decrease mortality, increase preservation of the eye, and prevent blindness. Along with the extensive use of IAC, it is important to apply noninvasive examination methods to assess the activity of the tumor and the risk factors for disease dissemination without histopathological confirmation. There are few studies that have assessed the value of magnetic resonance imaging (MRI) in evaluating the efficacy and complications of IAC for retinoblastoma...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414678/what-the-eyes-don-t-see-the-heart-does-grieve-over
#19
M Sciaudone, M Dery
INTRODUCTION: A 71 year old Peruvian woman presented with blurry vision and bilateral eye pain and had evidence of bilateral endophthalmitis on eye examination. Her past medical history was notable for multiple abdominal surgeries within the preceding months, including an incarcerated inguinal hernia repair which required an ileostomy placement, and cholecystitis requiring cholecystostomy tube placement. Over her multiple long hospitalizations, she developed bacteremia and fungemia on several occasions, with organisms including Enterobacter cloacae, Klebsiella pneumoniae, Bacteroides fragilis, Pseudomonas aeruginosa, Enterococcus faecium, and Candida albicans...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28413868/goniosynechialysis-and-repositioning-of-intraocular-lens-in-a-case-of-secondary-angle-closure-glaucoma
#20
Masaru Fujita, Masafumi Ogata, Yasuyuki Suzuki, Tsunetomo Ichihashi, Miyuki Nagahara, Kenji Kawai
PURPOSE: Implanting intraocular lens (IOL) in proper direction is important in cataract surgery to reduce the possibility of undesirable complications. We experienced a case who underwent vitrectomy combined with cataract surgery and developed secondary angle closure glaucoma caused by IOL misdirection. Goniosynechialysis (GSL) and repositioning of IOL successfully ameliorated the high intraocular pressure (IOP). CASE REPORT: A 64-year-old male with massive vitreous hemorrhage underwent vitrectomy combined with cataract surgery...
April 20, 2017: Tokai Journal of Experimental and Clinical Medicine
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