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https://www.readbyqxmd.com/read/28222498/creep-compliance-rheology-with-a-probe-like-cylindrical-geometry
#1
Kelly Connelly, Pooria Sharif-Kashani, Matt Farajzadeh, Jean-Pierre Hubschman, H Pirouz Kavehpour
BACKGROUND: Rheology experiments have been performed on the vitreous humor, a soft gel that rests inside of the eye, to study its viscoelastic behavior and underlying macromolecular structure. A significant challenge for experimentalists is preserving the macromolecular structure when removing vitreous from in vivo conditions. OBJECTIVE: We have developed a novel probe-like rheometer geometry that allows us to perform shear rheology experiments on the vitreous humor in situ...
February 10, 2017: Biorheology
https://www.readbyqxmd.com/read/28222445/blocking-il-17a-alleviates-diabetic-retinopathy-in-rodents
#2
Ao-Wang Qiu, Qing-Huai Liu, Jun-Ling Wang
BACKGROUND/AIMS: Interleukin (IL)-17A, a proinflammatory cytokine, has been implicated in several autoimmune diseases. However, it is unclear whether IL-17A is involved in diabetic retinopathy (DR), one of the most serious complications of autoimmune diabetes. This study aimed to demonstrate that IL-17A exacerbates DR by affecting retinal Müller cell function. METHODS: High glucose (HG)-treated rat Müller cell line (rMC-1) was exposed to IL-17A, anti-IL-17A-neutralizing monoclonal antibody (mAb) or/and anti-IL-17 receptor (R)A-neutralizing mAb for 24 h...
February 21, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28221258/endoillumination-assisted-modified-scleral-buckling
#3
Alexandre Assi, Youssef Abdelmassih, Sylvain El-Khoury
PURPOSE: To assess the anatomical and functional outcomes in addition to complications for endoillumination-assisted modified scleral buckling surgery using a noncontact Oculus BIOM wide-angle viewing system in patients with primary rhegmatogenous retinal detachment. METHODS: This is an interventional prospective noncomparative case series. Consecutive patients listed for scleral buckle surgery for primary rhegmatogenous retinal detachment were enrolled over an 18-month period and followed up for 1 year...
February 17, 2017: Retina
https://www.readbyqxmd.com/read/28213274/differentially-cleaving-peptides-as-a-strategy-for-controlled-drug-release-in-human-retinal-pigment-epithelial-cells
#4
Madhushree Bhattacharya, Sanjay Sarkhel, Jonne Peltoniemi, Robert Broadbridge, Marjo Tuomainen, Seppo Auriola, Arto Urtti
Currently, drug delivery to the posterior eye segment relies on intravitreal injections of therapeutics. This approach requires frequent injections and does not guarantee drug delivery to intracellular targets. Controlled release systems and nanoparticles are being investigated to mitigate these challenges but most of these approaches lack translational success to the clinics. In our present study, we report a peptide based delivery system that utilizes enzyme assisted cleavable linkers to release conjugated cargo within the retinal pigment epithelial (RPE) cells...
February 14, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28212679/histopathological-study-of-cardiac-lesions-in-methamphetamine-poisoning-related-deaths
#5
Maryam Akhgari, Homeira Mobaraki, Afshar Etemadi-Aleagha
BACKGROUND: Methamphetamine abuse is a worldwide health concern. Methamphetamine causes health hazards in many vital organs. It can cause damage to cardiac tissue via catecholamines release. Methamphetamine related deaths are becoming one of the most important problems in Iran. The purpose of the present study was to determine cardiac pathology in methamphetamine poisoning-related deaths. METHODS: The study included 100 cases of methamphetamine poisoning-related deaths and 100 cases as control group...
February 17, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28209509/the-raptor-visual-system-an-update
#6
J González-Martín-Moro, J L Hernández-Verdejo, A Clement-Corral
OBJECTIVE: Diurnal birds of prey (raptors) are considered the group of animals with highest visual acuity (VA). The purpose of this work is to review all the information recently published about the visual system of this group of animals. MATERIAL AND METHODS: A bibliographic search was performed in PubMed. The algorithm used was (raptor OR falcon OR kestrel OR hawk OR eagle) AND (vision OR «visual acuity» OR eye OR macula OR retina OR fovea OR «nictitating membrane» OR «chromatic vision» OR ultraviolet)...
February 13, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28208900/fuchs-heterochromic-iridocylitis-clinical-characteristics-and-outcome-of-cataract-extraction-with-intra-ocular-lens-implantation-in-a-kashmiri-population-a-hospital-based-study
#7
Wasim Rashid, Imtiyaz Lone, Adil Majid Mir, Aamir Rashid, Mehreen Latif
INTRODUCTION: Fuchs Heterochromic Iridocylitis (FHI) is a rare form of uveitis which is frequently complicated by cataract and glaucoma, but it does not show typical features of uveitis like pain, redness and posterior synechia. AIM: To study the clinical characteristics and outcome of cataract extraction with Intra Ocular Lens (IOL) implantation in patients with FHI. MATERIALS AND METHODS: The present prospective study was carried out in the Postgraduate Department of Ophthalmology, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Bemina from March 2012 to January 2015...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208187/optic-nerve-infiltration-and-vitreous-seeding-by-a-cerebral-glioblastoma
#8
Tin Yan Alvin Liu, Lilangi S Ediriwickrema, M Adelita Vizcaino, Adam Wenick, Neil R Miller
No abstract text is available yet for this article.
February 16, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28207726/long-term-survival-following-diabetic-vitrectomy
#9
Bia Z Kim, Kuo-Luong Lee, Stephen J Guest, David Worsley
AIM: To update long-term survival data on patients with proliferative diabetic retinopathy undergoing vitrectomy and to identify associated risk factors. METHODS: Retrospective clinical record review at a single New Zealand tertiary referral centre. A total of 182 eyes that underwent a vitrectomy for a diabetic vitreous haemorrhage and/or tractional retinal detachment between March 2000 and December 2010 were included. Kaplan-Meier survival curves and Cox-regression analyses were performed for survival rates and associated risk factors...
February 17, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28207607/pars-plana-vitrectomy-and-lensectomy-for-ectopia-lentis-with-and-without-the-induction-of-a-posterior-vitreous-detachment
#10
Mandeep S Singh, Edward J Casswell, Stavroula Boukouvala, Petros Petrou, David G Charteris
PURPOSE: Posterior hyaloid removal during pars plana vitrectomy and lensectomy for ectopia lentis is commonly performed, but may increase the risk of intraoperative retinal breaks and postoperative retinal detachment. This study evaluated outcomes after pars plana vitrectomy and lensectomy with or without posterior hyaloid removal. METHODS: This retrospective observational cohort study included ectopia lentis cases that underwent pars plana vitrectomy and lensectomy (2005-2014), with or without intraoperative induction of a posterior vitreous detachment (PVD)...
February 15, 2017: Retina
https://www.readbyqxmd.com/read/28204988/outcome-of-solid-state-532%C3%A2-nm-green-laser-in-high-risk-retinopathy-of-prematurity-at-a-tertiary-care-centre-in-india
#11
Kanika Chhabra, Prempal Kaur, Karamjit Singh, Anand Aggarwal, Dharamvir Chalia
PURPOSE: The purpose of this study was to analyse the outcome of solid-state green laser in high-risk retinopathy of prematurity (ROP) at a tertiary centre in India. METHODS: Fifty-nine eyes of 30 infants with high-risk ROP were recruited in this prospective, interventional study. High-risk ROP included prethreshold type 1 ROP and APROP. Laser photocoagulation was performed with 532 nm solid-state green laser (Novus Spectra, Lumenis, GmbH, Germany). RESULTS: Of the 30 infants, 18 were males (60%) and 12 were females (40%)...
February 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28204843/bread-wheat-milling-behavior-effects-of-genetic-and-environmental-factors-and-modeling-using-grain-mechanical-resistance-traits
#12
François-Xavier Oury, P Lasme, C Michelet, A Dubat, O Gardet, E Heumez, B Rolland, M Rousset, J Abecassis, C Bar L'Helgouac'h, V Lullien-Pellerin
Genetic (Pinb-D1 alleles) and environment (through vitreousness) have important effects on bread wheat milling behavior. SKCS optimal values corresponding to soft vitreous or hard mealy grains were defined to obtain the highest total flour yield. Near-isogenic lines of bread wheat that differ in hardness, due to distinct puroindoline-b alleles (the wild type, Pinb-D1a, or the mutated forms, Pinb-D1b or Pinb-D1d), were grown in different environments and under two nitrogen fertilization levels, to study genetic and environmental effects on milling behavior...
February 15, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28203200/late-onset-inadvertent-bleb-formation-following-pars-plana-m3-molteno-implant-tube-obstruction
#13
Anmar M Abdul-Rahman, Anthony Molteno
PURPOSE: To report a case of inadvertent bleb formation presenting 18 months after pars plana M3 Molteno implant tube obstruction in a patient with mixed mechanism glaucoma. MATERIALS AND METHODS: An 84-year-old Caucasian male with mixed mechanism glaucoma underwent slit-lamp examination, gonioscopy, colour anterior segment photography and anterior segment optical coherence tomography (AS-OCT). RESULTS: An inadvertent bleb developed 18 months after pars plana implant tube re-positioning with a 6/0 Vicryl tie ligature...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28203197/a-case-of-syphilitic-uveitis-in-which-vitreous-surgery-was-useful-for-the-diagnosis-and-treatment
#14
Takatoshi Kobayashi, Chihiro Katsumura, Hiromi Shoda, Nanae Takai, Sayako Takeda, Takako Okamoto, Koichi Maruyama, Rei Tada, Kensuke Tajiri, Teruyo Kida, Tsunehiko Ikeda
PURPOSE: To report a case of atypical syphilitic uveitis complicated with retinal vasculitis, proliferative retinopathy, and vitreous hemorrhage in which vitreous surgery was useful for the diagnosis and treatment. CASE REPORT: A 38-year-old female was referred to our hospital after noticing visual disturbance in her right eye. Fundoscopy examination of that eye revealed retinal phlebitis accompanied by retinal hemorrhage and soft exudate, and remarkable exudative changes in the retinal vessels from the upper arcade to the macula region...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28203195/27-gauge-vitrectomy-for-symptomatic-vitreous-floaters-with-topical-anesthesia
#15
Zhong Lin, Nived Moonasar, Rong Han Wu, Robin R Seemongal-Dass
PURPOSE: Traditionally acceptable methods of anesthesia for vitrectomy surgery are quite varied. However, each of these methods has its own potential for complications that can range from minor to severe. The surgery procedure of vitrectomy for symptomatic vitreous floaters is much simpler, mainly reflecting in the nonuse of sclera indentation, photocoagulation, and the apparently short surgery duration. The use of 27-gauge cannulae makes the puncture of the sclera minimally invasive...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28203191/airbag-associated-severe-blunt-eye-injury-causes-choroidal-rupture-and-retinal-hemorrhage-a-case-report
#16
Shih Hao Wang, Chen Chee Lim, Yu Ti Teng
A case of choroidal rupture caused by airbag-associated blunt eye trauma and complicated with massive subretinal hemorrhage and vitreous hemorrhage that was successfully treated with intravitreal injection of expansile gas and bevacizumab is presented. A 53-year-old man suffered from loss of vision in his right eye due to blunt eye trauma by a safety airbag after a traffic accident. On initial examination, the patient had no light perception in his right eye. Dilated ophthalmoscopy revealed massive subretinal hemorrhage with macular invasion and faint vitreous hemorrhage...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28196197/white-vitreous-deposits-after-subtenon-steroid-injection-more-than-meets-the-eye
#17
Pooja G Garg, Joseph M Simonett, Amani A Fawzi
No abstract text is available yet for this article.
February 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28195618/preclinical-acute-ocular-safety-study-of-combined-intravitreal-carboplatin-and-etoposide-phosphate-for-retinoblastoma
#18
Brian G Mohney, Victor M Elner, Andrew B Smith, J William Harbour, Brian D Smith, David C Musch, Stephen J Smith
BACKGROUND AND OBJECTIVE: To describe the ocular toxicity of intravitreal carboplatin and etoposide phosphate (VP16P) in Dutch-Belted rabbits. MATERIALS AND METHODS: Twenty-two adult male Dutch-Belted rabbits (Cohort 1) each received a single, bilateral intravitreal injection (0.05 mL). For Cohort 1, safety was assessed via electroretinograms (ERGs) and ocular examination. Of nine total groups in Cohort 1, the first five received the following single agents: Group 1: normal saline; Group 2: VP16P 75 µg; Group 3: VP16P 100 µg; Group 4: carboplatin 4 µg; and Group 5: carboplatin 8 µg...
February 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28195617/pediatric-traumatic-retinal-detachments-clinical-characteristics-and-outcomes
#19
Sabahattin Sul, Gökhan Gurelik, Safak Korkmaz, Sengül Ozdek, Berati Hasanreisoglu
BACKGROUND AND OBJECTIVE: To compare clinical characteristics and surgical outcomes of retinal detachment (RD) after open globe injuries (OGIs) and closed globe injuries (CGIs). PATIENTS AND METHODS: One hundred ten eyes of 110 patients aged 17 years or younger who underwent primary RD repair after OGI and CGI between 2010 and 2013 were reviewed retrospectively. RESULTS: Cataract (59.8% vs. 21.7%; P = .002) and vitreous hemorrhage (54% vs...
February 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28195616/clinical-features-and-management-of-subretinal-abscesses-secondary-to-methicillin-resistant-staphylococcus-aureus-endogenous-endophthalmitis
#20
Jorge Fortun, Yasha S Modi, Angela Bessette, Jordan Heffez, Petros Carvounis, Daniel S Petkovsek, Nicholas G Anderson, Daniel Martin, Sunil Srivastava
BACKGROUND AND OBJECTIVE: To describe the clinical features, management, and immediate outcomes of patients with subretinal abscesses secondary to methicillin-resistant Staphylococcus aureus (MRSA) endogenous endophthalmitis. PATIENTS AND METHODS: Eleven eyes of seven patients were identified by retrospective chart review. Demographics, initial presentation, examination findings, imaging, cultures, treatments, and short-term outcomes were reviewed. RESULTS: Eleven eyes of seven patients presented with subretinal abscesses secondary to MRSA endogenous endophthalmitis...
February 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
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