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https://www.readbyqxmd.com/read/28446866/the-contribution-of-immune-infiltrates-to-ototoxicity-and-cochlear-hair-cell-loss
#1
REVIEW
Megan B Wood, Jian Zuo
Cells of the immune system have been shown to infiltrate the cochlea after acoustic trauma or ototoxic drug treatment; however, the contribution of the immune system to hair cell loss in the inner ear is incompletely understood. Most studies have concentrated on the immediate innate response to hair cell damage using CD45 as a broad marker for all immune cells. More recent studies have used RNA sequencing, GeneChip arrays and quantitative PCR to analyze gene expression in the entire cochlea after auditory trauma, leading to a better understanding of the chemokines and cytokines that attract immune cells to the cochlea...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28446678/differential-involvement-during-latent-hsv-1-infection-of-the-superior-and-inferior-divisions-of-the-vestibular-ganglia-implications-for-vestibular-neuritis
#2
Susanne Himmelein, Anja Lindemann, Inga Sinicina, Anja K E Horn, Thomas Brandt, Michael Strupp, Katharina Hüfner
Controversy still surrounds both the etiology and pathophysiology of vestibular neuritis (VN). Especially uncertain is why the superior vestibular nerve (SVN) is more frequently affected than the inferior part (IVN), which is partially or totally spared. To address this question we developed an improved method for preparing human vestibular ganglia (VG) and nerve. Subsequently macro- and micro-anatomical as well as PCR studies were performed on 38 human ganglia from 38 individuals. The SVN was 2.4 mm longer than the IVN, and in 65% of the cases the IVN ran in two separate bony canals, which was not the case for the SVN...
April 26, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28443600/retroauricular-approach-for-targeted-cochlear-therapy-experiments-in-wistar-albino-rats
#3
Selçuk Mülazimoğlu, Emre Ocak, Gülşah Kaygusuz, Mustafa Kürşat Gökcan
BACKGROUND: As the idea of stem cell technology in the treatment of sensorial hearing loss has emerged over the past decades, the need for in vivo models for related experiments becomes explicit. One of the most common experimental models for inner ear stem cell delivery experiments is the Wistar albino rat (WAR). AIMS: To investigate the surgical anatomy of the temporal bone of the WAR with respect to the dissection steps, operative techniques, and potential pitfalls from surgery...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28442169/cochlear-implantation-in-children-with-anomalous-cochleovestibular-anatomy
#4
REVIEW
Ana Sofia Melo, Jorge Martins, João Silva, Jorge Quadros, António Paiva
OBJECTIVE: The aim of the study is to assess the audiological and surgical outcome after cochlear implantation in children with inner ear malformation and to compare them with a group of congenitally deaf children implantees without inner ear malformation. INTRODUCTION: Children with profound sensorineural deafness with malformations of the inner ear represent a challenge, accounting to 5-15% of congenital sensorineural deafness. These cases were originally regarded as a contraindication for cochlear implant surgery...
April 22, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28442065/the-morphological-and-functional-development-of-the-stria-vascularis-in-miniature-pigs
#5
Weiwei Guo, Haijin Yi, Zhang Yan, Lili Ren, Lei Chen, Li Dong Zhao, Yu Ning, David Z Z He, Shi-Ming Yang
The purpose of this study was to examine the morphological and functional development of the lateral wall of the scala media of the cochlea in miniature pigs; light and transmission electron microscopy and electrophysiology were used for this purpose. We showed that the lateral wall of the scala media of the cochlea appears at embryonic Day 21 (E21) when the cochlear duct begins to form. From E28 to E49, the lateral wall can be distinguished according to its position along the cochlea. At E56, cells in the lateral wall begin to differentiate into three different types...
March 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28441806/-possible-reasons-for-cerebrospinal-fluid-gusher-in-cochlear-implantation-with-inner-ear-abnormality
#6
S P Sun, W Lu, X M Men, B Zuo, Y B Lei
Objective: To discuss the possible reasons for cerebrospinal fluid (CSF) gusher in cochlear implantation (CI) with inner ear abnormality. Method: A retrospective analysis was performed on 340 cases who underwent CI from January 2013 to December 2016 in Division of Otology, Otorhinolaryngology Hospital, the First Affiliated Hospital of Zhengzhou University. Among them, 96 cases had inner ear abnormalities. Imaging examinations were performed on these patients, and classification of inner ear malformation was done according to the results...
April 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28441300/speech-detection-in-noise-for-young-bilaterally-implanted-children-is-there-evidence-of-binaural-benefit-over-the-shadowed-ear-alone
#7
Karyn L Galvin, Richard C Dowell, Richard J van Hoesel, Mansze Mok
OBJECTIVES: To measure binaural benefit over the shadowed ear alone for young bilateral cochlear implant (CI) users. It was hypothesized that children who received bilateral CIs at a young age (<4 years), and had significant bilateral experience, would demonstrate lower detection thresholds for speech sounds in background noise in the bilateral CI over the unilateral CI condition when the added CI was ipsilateral to the noise source. DESIGN: Children receiving bilateral CIs at the Eye and Ear Hospital Clinic in Melbourne were invited to participate in a wider research project evaluating outcomes; those participating in the wider project who were bilaterally implanted by 4 years and were approximately 2 years postoperative were included in the present study...
April 22, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28441230/cochlear-implantation-in-adults-with-asymmetric-hearing-loss-benefits-of-bimodal-stimulation
#8
Maarten Caspar van Loon, Cas Smits, Conrad F Smit, Erik F Hensen, Paul Merkus
OBJECTIVE: This study addresses the outcome of cochlear implantation in addition to hearing aid use in patients with asymmetric sensorineural hearing loss. STUDY DESIGN: Prospective longitudinal study. SETTING: Tertiary referral center. PATIENTS: Seven adults with asymmetric sensorineural hearing loss, i.e., less than 30% aided speech recognition in their worst hearing ear and 60 to 85% speech recognition in their best hearing ear...
April 24, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28440437/autophagy-related-protein-12-associates-with-anti-apoptotic-b-cell-lymphoma-2-to-promote-apoptosis-in-gentamicin-induced-inner-ear-hair-cell-loss
#9
Xiaofeng Ma, Yongze Liu, Waqas Muhammad, Dingding Liu, Junguo Wang, Han Zhou, Xia Gao, Xiaoyun Qian
The aim of the present study was to investigate the underlying mechanisms of autophagy in a gentamicin (GM)-induced ototoxic model, and to establish whether the blocking of autophagy significantly increases the survival of inner ear hair cells. Cochleae were carefully dissected from four day‑old C57BL/6J mice and randomly divided into three groups prior to explant culture: Control (culture medium), GM‑treated (culture medium + GM) and GM + 3-methyladenine (3-MA; culture medium + GM + 3‑MA). Transmission electron microscopy, immunofluorescence and western blotting were performed to observe the expression of the autophagy protein microtubule‑associated protein 1A/B‑light chain 3 in explant cultures treated with GM and the autophagy inhibitor 3‑MA...
April 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28438727/influence-of-telecommunication-modality-internet-transmission-quality-and-accessories-on-speech-perception-in-cochlear-implant-users
#10
Georgios Mantokoudis, Roger Koller, Jérémie Guignard, Marco Caversaccio, Martin Kompis, Pascal Senn
BACKGROUND: Telecommunication is limited or even impossible for more than one-thirds of all cochlear implant (CI) users. OBJECTIVE: We sought therefore to study the impact of voice quality on speech perception with voice over Internet protocol (VoIP) under real and adverse network conditions. METHODS: Telephone speech perception was assessed in 19 CI users (15-69 years, average 42 years), using the German HSM (Hochmair-Schulz-Moser) sentence test comparing Skype and conventional telephone (public switched telephone networks, PSTN) transmission using a personal computer (PC) and a digital enhanced cordless telecommunications (DECT) telephone dual device...
April 24, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28438658/antioxidants-reduce-neurodegeneration-and-accumulation-of-pathologic-tau-proteins-in-the-auditory-system-after-blast-exposure
#11
Xiaoping Du, Matthew B West, Qunfeng Cai, Weihua Cheng, Donald L Ewert, Wei Li, Robert A Floyd, Richard D Kopke
Cochlear neurodegeneration commonly accompanies hair cell loss resulting from aging, ototoxicity, or exposures to intense noise or blast overpressures. However, the precise pathophysiological mechanisms that drive this degenerative response have not been fully elucidated. Our laboratory previously demonstrated that non-transgenic rats exposed to blast overpressures exhibited marked somatic accumulation of neurotoxic variants of the microtubule-associated protein, Tau, in the hippocampus. In the present study, we extended these analyses to examine neurodegeneration and pathologic Tau accumulation in the auditory system in response to blast exposure and evaluated the potential therapeutic efficacy of antioxidants on short-circuiting this pathological process...
April 21, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28437361/cochlear-implantation-vast-unmet-need-to-address-deafness-globally
#12
Mehmet İlhan Şahin, Jessica E Sagers, Konstantina M Stankovic, Mehmet İlhan Şahin, Konstantina M Stankovic, Jessica E Sagers, Konstantina M Stankovic
No abstract text is available yet for this article.
April 21, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28437273/assessing-sensorineural-hearing-loss-using-various-transient-evoked-otoacoustic-emission-stimulus-conditions
#13
Daniel B Putterman, Douglas H Keefe, Lisa L Hunter, Angela C Garinis, Denis F Fitzpatrick, Garnett P McMillan, M Patrick Feeney
OBJECTIVES: An important clinical application of transient-evoked otoacoustic emissions (TEOAEs) is to evaluate cochlear outer hair cell function for the purpose of detecting sensorineural hearing loss (SNHL). Double-evoked TEOAEs were measured using a chirp stimulus, in which the stimuli had an extended frequency range compared to clinical tests. The present study compared TEOAEs recorded using an unweighted stimulus presented at either ambient pressure or tympanometric peak pressure (TPP) in the ear canal and TEOAEs recorded using a power-weighted stimulus at ambient pressure...
April 21, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28436245/book-review-pediatric-cochlear-implantation-learning-and-the-brain-kirk-nancy-m-young-karen-iler-eds-pediatric-cochlear-implantation-learning-and-the-brain-new-york-ny-springer-2016-365-pages-83-129-hardcover-122-kindle
#14
https://www.readbyqxmd.com/read/28432874/delayed-changes-in-auditory-status-in-cochlear-implant-users-with-preserved-acoustic-hearing
#15
Rachel A Scheperle, Viral D Tejani, Julia K Omtvedt, Carolyn J Brown, Paul J Abbas, Marlan R Hansen, Bruce J Gantz, Jacob J Oleson, Marie V Ozanne
This retrospective review explores delayed-onset hearing loss in 85 individuals receiving cochlear implants designed to preserve acoustic hearing at the University of Iowa Hospitals and Clinics between 2001 and 2015. Repeated measures of unaided behavioral audiometric thresholds, electrode impedance, and electrically evoked compound action potential (ECAP) amplitude growth functions were used to characterize longitudinal changes in auditory status. Participants were grouped into two primary categories according to changes in unaided behavioral thresholds: (1) stable hearing or symmetrical hearing loss and (2) delayed loss of hearing in the implanted ear...
April 12, 2017: Hearing Research
https://www.readbyqxmd.com/read/28432471/differentiating-middle-ear-and-medial-olivocochlear-effects-on-transient-evoked-otoacoustic-emissions
#16
Kendra L Marks, Jonathan H Siegel
The response of the inner ear is modulated by the middle ear muscle (MEM) and olivocochlear (OC) efferent systems. Both systems can be activated reflexively by acoustic stimuli delivered to one or both ears. The acoustic middle ear muscle reflex (MEMR) controls the transmission of acoustic signals through the middle ear, while reflex activation of the medial component of the olivocochlear system (the MOCR) modulates cochlear mechanics. The relative prominence of the two efferent systems varies widely between species...
April 21, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28431308/hyperexcitability-of-inferior-colliculus-and-acoustic-startle-reflex-with-age-related-hearing-loss
#17
Binbin Xiong, Ana'am Alkharabsheh, Senthilvelan Manohar, Guang-Di Chen, Ning Yu, Xiaoming Zhao, Richard Salvi, Wei Sun
Chronic tinnitus and hyperacusis often develop with age-related hearing loss presumably due to aberrant neural activity in the central auditory system (CAS) induced by cochlear pathologies. However, the full spectrum of physiological changes that occur in the CAS as a result age-related hearing loss are still poorly understood. To address this issue, neurophysiological measures were obtained from the cochlea and the inferior colliculus (IC) of 2, 6 and 12 month old C57BL/6J mice, a mouse model for early age-related hearing loss...
March 27, 2017: Hearing Research
https://www.readbyqxmd.com/read/28429126/assessing-the-role-of-place-and-timing-cues-in-coding-frequency-and-amplitude-modulation-as-a-function-of-age
#18
Kelly L Whiteford, Heather A Kreft, Andrew J Oxenham
Natural sounds can be characterized by their fluctuations in amplitude and frequency. Ageing may affect sensitivity to some forms of fluctuations more than others. The present study used individual differences across a wide age range (20-79 years) to test the hypothesis that slow-rate, low-carrier frequency modulation (FM) is coded by phase-locked auditory-nerve responses to temporal fine structure (TFS), whereas fast-rate FM is coded via rate-place (tonotopic) cues, based on amplitude modulation (AM) of the temporal envelope after cochlear filtering...
April 20, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28428741/assessing-auditory-processing-deficits-in-tinnitus-and-hearing-impaired-patients-with-the-auditory-behavior-questionnaire
#19
Isabel Diges, Francisco Simón, Pedro Cobo
Background and Purpose: Auditory processing disorders (APD), tinnitus and hearing loss (HL) are typical issues reported by patients in audiologic clinics. These auditory impairments can be concomitant or mutually excluding. APD are not necessarily accompanied by significant HL, whereas many adults exhibit peripheral HL and typical cognitive deficits often associated with APD. Since HL, tinnitus and APD affects to several parts of the ascending auditory pathway from the periphery to the auditory cortex, there could be some interrelationship between them...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28426889/concurrent-and-longitudinal-predictors-of-reading-for-deaf-and-hearing-children-in-primary-school
#20
Margaret Harris, Emmanouela Terlektsi, Fiona Elizabeth Kyle
Forty-one children with severe-profound prelingual hearing loss were assessed on single word reading, reading comprehension, English vocabulary, phonological awareness and speechreading at three time points, 1 year apart (T1-T3). Their progress was compared with that of a group of hearing children of similar nonverbal IQ, initially reading at the same level. Single word reading improved at each assessment point for the deaf children but there was no growth in reading comprehension from T2 to T3. There were no differences between children with cochlear implants and those with hearing aids on either reading measure but orally educated children had higher scores than children who signed in the classroom...
April 1, 2017: Journal of Deaf Studies and Deaf Education
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