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https://www.readbyqxmd.com/read/28223798/transferrin-receptor-targeted-ph-sensitive-micellar-system-for-diminution-of-drug-resistance-and-targetable-delivery-in-multidrug-resistant-breast-cancer
#1
Wei Gao, Guihua Ye, Xiaochuan Duan, Xiaoying Yang, Victor C Yang
The emergence of drug resistance is partially associated with overproduction of transferrin receptor (TfR). To overcome multidrug resistance (MDR) and achieve tumor target delivery, we designed a novel biodegradable pH-sensitive micellar system modified with HAIYPRH, a TfR ligand (7pep). First, the polymers poly(l-histidine)-coupled polyethylene glycol-2000 (PHIS-PEG2000) and 7pep-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000 (7pep-DSPE-PEG2000) were synthesized, and the mixed micelles were prepared by blending of PHIS-PEG2000 and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000 (DSPE-PEG2000) or 7pep-DSPE-PEG2000 (7-pep HD micelles)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28208576/optimization-for-the-production-of-deoxynivalenoland-zearalenone-by-fusarium-graminearum-usingresponse-surface-methodology
#2
Li Wu, Lijuan Qiu, Huijie Zhang, Juan Sun, Xuexu Hu, Bujun Wang
Fusarium mycotoxins deoxynivalenol (DON) and zearalenone (ZEN) are the mostcommon contaminants in cereals worldwide, causing a wide range of adverse health effects onanimals and humans. Many environmental factors can affect the production of these mycotoxins.Here, we have used response surface methodology (RSM) to optimize the Fusarium graminearumstrain 29 culture conditions for maximal toxin production. Three factors, medium pH, incubationtemperature and time, were optimized using a Box-Behnken design (BBD)...
February 10, 2017: Toxins
https://www.readbyqxmd.com/read/28129587/phisphorylation-the-emergence-of-histidine-phosphorylation-as-a-reversible-regulatory-modification
#3
REVIEW
Stephen Rush Fuhs, Tony Hunter
Histidine phosphorylation is crucial for prokaryotic signal transduction and as an intermediate for several metabolic enzymes, yet its role in mammalian cells remains largely uncharted. This is primarily caused by difficulties in studying histidine phosphorylation because of the relative instability of phosphohistidine (pHis) and lack of specific antibodies and methods to preserve and detect it. The recent synthesis of stable pHis analogs has enabled development of pHis-specific antibodies and their use has started to shed light onto this important, yet enigmatic posttranslational modification...
January 24, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/28107287/case-volume-and-revisits-in-children-undergoing-gastrostomy-tube-placement
#4
Marjorie J Arca, Shawn J Rangel, Matt Hall, David H Rothstein, Martin L Blakely, Peter C Minneci, Samir S Shah, Kurt F Heiss, Charles L Snyder, Loren Berman, Marybeth Browne, Charles D Vinocur, Mehul V Raval, Adam B Goldin
OBJECTIVE: Emergency department (ED) visits and hospital readmissions are common following gastrostomy tube (GT) placement in children. We sought to characterize inter-hospital variation in revisit rates and explore the association between this outcome and hospital-specific GT case volume. STUDY DESIGN: We conducted a retrospective cohort study from 38 hospitals using the Pediatric Health Information System (PHIS) database. Patients <18 years who had a GT placed in 2010-2012 were assessed for a GT-related (mechanical or infectious) ED visit or inpatient readmission at 30 and 90 days following discharge from GT placement...
January 20, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28097092/comparative-interactomics-for-virus-human-protein-protein-interactions-dna-viruses-versus-rna-viruses
#5
Saliha Durmuş, Kutlu Ö Ülgen
Viruses are obligatory intracellular pathogens and completely depend on their hosts for survival and reproduction. The strategies adopted by viruses to exploit host cell processes and to evade host immune systems during infections may differ largely with the type of the viral genetic material. An improved understanding of these viral infection mechanisms is only possible through a better understanding of the pathogen-host interactions (PHIs) that enable viruses to enter into the host cells and manipulate the cellular mechanisms to their own advantage...
January 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28079865/differences-in-mortality-characteristics-in-neonates-with-down-s-syndrome
#6
C L Cua, U Haque, S Santoro, L Nicholson, C H Backes
OBJECTIVE: Neonates with Down's syndrome (nDS) may have multiple medical issues that place them at increased risk for mortality during the newborn period. Goal of this study was to determine if there are differences in baseline characteristics, medical complications or procedures performed during hospitalization between nDS who survived versus those who died during initial hospitalization. STUDY DESIGN: Data from 2000 to 2014 were reviewed using the Pediatric Health Information Systems (PHIS) database on all DS patients admitted to the hospital <30 days postnatal life...
January 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28057296/routine-post-operative-esophagram-is-not-necessary-after-repair-of-esophageal-atresia
#7
Jamie Golden, Natalie E Demeter, Joanna C Lim, Henri R Ford, Jeffrey S Upperman, Christopher P Gayer
INTRODUCTION: Esophagrams are routinely performed following repair of esophageal atresia (EA) with or without tracheoesophageal fistula (TEF); however, its utility has not been validated. METHODS: EA/TEF repair performed from 2003 to 2014 at a single pediatric hospital and from 2004 to 2014 in the Pediatric Health Information System (PHIS) database were retrospectively reviewed to determine utility of esophagrams. RESULTS: Esophagram was performed in 99% of patients at our institution (N = 105)...
December 30, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/28006885/epidemiology-and-outcomes-of-cardiac-arrest-among-children-with-down-syndrome-a-multicenter-analysis
#8
Asif Padiyath, Mallikarjuna Rettiganti, Jeffrey M Gossett, Sachin D Tadphale, Xiomara Garcia, Paul M Seib, Punkaj Gupta
BACKGROUND: With the increasing prevalence of Down syndrome, it is unknown if children with Down syndrome are associated with increased incidence of cardiac arrest and poor outcomes after cardiac arrest. The objective of this study was to evaluate the epidemiology of cardiac arrest and mortality after cardiac arrest among critically ill children with and without Down syndrome. METHODS: Patients ≤ 18 years admitted at a Pediatric Health Information Systems (PHIS) participating Intensive Care Unit were included (2004-2014)...
December 22, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27980766/unwitnessed-head-trauma-the-bamboo-did-it
#9
Rodrigo Sousa, Ângela Luz, Francisco Abecasis, Marisa Vieira
Unwitnessed penetrating head injuries (PHIs) are often challenging. The inability to locate a foreign body should not exclude this diagnosis nor should it delay treatment. Attempts must be made to clarify the mechanism of injury, as this may allow for a better understanding of the patient's condition.
December 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27979259/a-simple-extraction-method-for-the-detection-and-quantification-of-polyoxin-d-a-nucleoside-antibiotic-in-butterbur-using-uplc-ms-ms
#10
Md Musfiqur Rahman, A M Abd El-Aty, Sung-Woo Kim, Tae-Woong Na, Ho-Chul Shin, Su-Myeong Hong, Jae-Han Shim
An effective analytical method was developed for the detection and quantification of polyoxin D in butterbur using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Samples were extracted using acidified deionised water and purified via solid-phase extraction (SPE) using an HLB cartridge. An external matrix-matched standard calibration curve was prepared, which provided an excellent linearity with a coefficient of determination (R(2)) ⩾0.999. Limits of detection (LOD) and quantification (LOQ) were 0...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27923247/patterns-of-empiric-antibiotic-administration-for-presumed-early-onset-neonatal-sepsis-in-neonatal-intensive-care-units-in-the-united-states
#11
Emily A Oliver, Patricia B Reagan, Jonathan L Slaughter, Catalin S Buhimschi, Irina A Buhimschi
Objective To evaluate current patterns in empiric antibiotic use for early-onset neonatal sepsis (EONS). Study Design Retrospective population-based cohort study of newborns admitted on postnatal day 0 to 1 and discharged from NICUs participating in the Pediatric Health Information System (PHIS 2006-2013). Analyses included frequency of antibiotic initiation within 3 days of birth, duration of first course, and variation among hospitals. Results Of 158,907 newborns, 118,624 (74.7%) received antibiotics on or before postnatal day 3...
December 6, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27873234/eeg-monitoring-and-antiepileptic-drugs-in-children-with-severe-tbi
#12
Christopher M Ruzas, Peter E DeWitt, Kimberly S Bennett, Kevin E Chapman, Nicole Harlaar, Tellen D Bennett
BACKGROUND: Traumatic brain injury (TBI) causes substantial morbidity and mortality in US children. Post-traumatic seizures (PTS) occur in 11-42% of children with severe TBI and are associated with unfavorable outcome. Electroencephalographic (EEG) monitoring may be used to detect PTS and antiepileptic drugs (AEDs) may be used to treat PTS, but national rates of EEG and AED use are not known. The purpose of this study was to describe the frequency and timing of EEG and AED use in children hospitalized after severe TBI...
November 21, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27862214/the-role-of-acuity-of-illness-at-presentation-in-early-mortality-in-black-children-with-acute-myeloid-leukemia
#13
Lena E Winestone, Kelly D Getz, Tamara P Miller, Jennifer J Wilkes, Leah Sack, Yimei Li, Yuan-Shung Huang, Alix E Seif, Rochelle Bagatell, Brian T Fisher, Andrew J Epstein, Richard Aplenc
Black patients with acute myeloid leukemia (AML) experience higher mortality than White patients. We compared induction mortality, acuity of illness prior to chemotherapy, and insurance type between Black and White patients to assess whether acuity of presentation mediates the disparity. Within a retrospective cohort of 1,122 children with AML treated with two courses of standard induction chemotherapy between 2004 and 2014 in the Pediatric Health Information System (PHIS) database, the association between race (Black versus White) and inpatient mortality during induction was examined...
November 10, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27849868/226-blood-transfusion-utilization-in-neonates-following-cardiac-surgery-using-the-phis-database
#14
Michael Wolf, Courtney McCracken, Elizabeth Wang, William Mahle
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849814/171-invasive-procedures-for-severe-pediatric-pulmonary-hypertension-an-analysis-of-the-phis-database
#15
Ryan Coleman, Corey Chartan, Brady Moffett, Elizabeth Neptune, Nidhy Varghese, Fadel Ruiz, George Mallory, Lara Shekerdemian
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27821262/variation-in-surgical-antibiotic-prophylaxis-for-outpatient-pediatric-urological-procedures-at-united-states-children-s-hospitals
#16
Katherine H Chan, Teresa Bell, Mark Cain, Aaron Carroll, Brian D Benneyworth
PURPOSE: Guidelines recommend surgical antibiotic prophylaxis for clean-contaminated procedures but none for clean procedures. The purpose of this study was to describe variations in surgical antibiotic prophylaxis for outpatient urological procedures at United States children's hospitals. MATERIALS AND METHODS: Using the PHIS (Pediatric Health Information System®) database we performed a retrospective cohort study of patients younger than 18 years who underwent clean and/or clean-contaminated outpatient urological procedures from 2012 to 2014...
November 4, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27799766/decoration-of-ph-sensitive-copolymer-micelles-with-tumor-specific-peptide-for-enhanced-cellular-uptake-of-doxorubicin
#17
Qing Chen, Miaomiao Long, Lipeng Qiu, Mengqin Zhu, Zhen Li, Mingxi Qiao, Haiyang Hu, Xiuli Zhao, Dawei Chen
To improve the targeting efficacy of hyaluronic acid (HA)-based micelles, pH-sensitive mixed micelles based on HA-g-poly(L-histidine) (PHis) and d-α-tocopheryl polyethylene glycol 2000 copolymers were prepared and decorated with human epidermal growth factor receptor 2 (Her2) peptide, a tumor cell-specific peptide ligand, on their surface. The doxorubicin-loaded micelles (HA-PHis/peptide-d-α-tocopheryl polyethylene glycol 2000 mixed micelles [PHTM]) were characterized to have a unimodal size distribution and pH-dependent drug release pattern...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27766551/validated-cost-comparison-of-open-vs-robotic-pyeloplasty-in-american-children-s-hospitals
#18
William E Bennett, Benjamin M Whittam, Konrad M Szymanski, Richard C Rink, Mark P Cain, Aaron E Carroll
The objective of this study is to determine the cost and charge differences between patients undergoing open vs. robotic pyeloplasty. This is a retrospective analysis of the Pediatric Health Information System (PHIS) database in patients undergoing pyeloplasty between 2004 and 2013 conducted in large pediatric children's hospitals in the United States which contribute to PHIS. The participants included all pediatric patients undergoing pyeloplasty at these institutions. We assessed RCC-based cost, charge details, length of stay, and the presence of complications, and compared them between open and robotic cases...
October 20, 2016: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/27762480/variation-in-resource-utilization-in-liver-transplantation-at-freestanding-children-s-hospitals
#19
Jennifer A Minneman, James L Grijalva, Michael J LaQuaglia, Heung Bae Kim, Shawn J Rangel, Khashayar Vakili
We sought to examine the relationship between liver transplant-related total cost, patient outcome, and hospital resource utilization at freestanding children's hospitals. Using the PHIS database, a retrospective study of 374 patients that underwent liver transplantation at 15 freestanding children's hospitals from July 2010 to December 2012 was performed. One-year graft failure and patient mortality rates from July 2010 to December 2012 for each center were also obtained from the SRTR. There was a 5.1-fold difference in median cost (median $146 444, range $59 487-302 058, P<...
November 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27645335/hospital-admission-rates-for-pediatric-multiple-sclerosis-in-the-united-states-using-the-pediatric-health-information-system-phis
#20
Amy M Lavery, Brenda L Banwell, Geraldine Liu, Amy T Waldman
BACKGROUND: The onset of multiple sclerosis (MS) during childhood or adolescence is increasingly recognized in the United States. Administrative databases quantify healthcare utilization as measured by hospital admissions, providing insight into the impact of MS in the pediatric population. OBJECTIVE: We examine the frequency of hospital admissions for pediatric MS in the US using the Pediatric Health Information System (PHIS) database. METHODS: Data was extracted from the PHIS database using the ICD-9 code for MS (340...
September 2016: Multiple Sclerosis and related Disorders
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