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https://www.readbyqxmd.com/read/29766676/identification-of-hospitalized-tracheostomy-and-ventilator-dependent-patients-in-administrative-data
#1
Barbara K Giambra, Colleen Mangeot, Dan T Benscoter, Maria T Britto
BACKGROUND: Patients with established tracheostomy and ventilator dependence are hospitalized more frequently and use more healthcare resources than other patients with complex chronic conditions. However, data to compare variation in hospitalization and resource use among patients in this population across the United States is deficient, partly due to the lack of structured methods to query national databases. AIM: Determine the best method for identifying the subset of children with established tracheostomy and ventilator dependence in Pediatric Health Information System (PHIS)...
May 15, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29722085/polyhistidine-based-metal-coordination-hydrogels-with-physiologically-relevant-ph-responsiveness-and-enhanced-stability-through-a-novel-synthesis
#2
Quan Tang, Dinglei Zhao, Qiang Zhou, Haiyang Yang, Kang Peng, Xingyuan Zhang
Utilizing the abnormal physiological conditions of disease tissues can result in a site-specific functionality with high control and efficiency of stimuli-responsive hydrogels. Here, a physiologically relevant pH-responsive and self-healing hydrogel is reported based on coordination between Ni2+ and four-arm poly(ethylene glycol)-b-polyhistidine (4PEG-PHis) that is synthesized by a novel and facile PHis preparation method using amino-terminalized four-arm PEG as the macroinitiator. Reversible PHisNi coordination bonds endow the hydrogel with multistimuli-triggered sol-gel transition (physiologically relevant pH, EDTA) and self-healing properties...
May 3, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29715194/trends-in-the-use-of-puberty-blockers-among-transgender-children-in-the-united-states
#3
Carla Marisa Lopez, Daniel Solomon, Susan D Boulware, Emily R Christison-Lagay
BACKGROUND: The objective of the study was to identify national trends in the utilization of histrelin acetate implants among transgender children in the United States. METHODS: We analyzed demographic, diagnostic and treatment data from 2004 to 2016 on the use of histrelin acetate reported to the Pediatric Health Information System (PHIS) to determine the temporal trends in its use for transgender-related billing diagnoses, e.g. "gender identity disorder"...
May 1, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29677081/changes-in-pediatric-heart-transplant-hospitalization-costs-over-time
#4
Justin Godown, Cary Thurm, Matt Hall, Jonathan H Soslow, Brian Feingold, Bret A Mettler, Andrew H Smith, David W Bearl, Debra A Dodd
BACKGROUND: Despite significant changes in the past decade for children undergoing heart-transplantation, including the evolution of mechanical circulatory support and increasing patient complexity, costs and resource utilization have not been reassessed. We sought to utilize a novel linkage of clinical-registry and administrative data to examine changes in hospitalization costs over time in this population. METHODS: We identified all pediatric heart transplant recipients in a unique linked PHIS/SRTR dataset (2002-2016)...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29644453/analysis-of-factors-predicting-surgical-intervention-and-associated-costs-in-pediatric-breast-masses-a-single-center-study
#5
E Graham Englert, Guillermo Ares, Andrea Henricks, Karen Rychlik, Catherine J Hunter
PURPOSE: Finding a breast mass in a child provokes apprehension in parents, especially in those with a family history of breast cancer. Clinicians must decide between serial imaging or biopsy of the mass. Herein, we identify management differences in those with and without a positive family history, as well as identify cost differences. METHODS: An institutional retrospective review was performed of patients (2-18 years of age) with a diagnosis of breast mass...
April 11, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29601458/epidemiology-and-clinical-relevance-of-toxic-shock-syndrome-in-us-children
#6
James T Gaensbauer, Meghan Birkholz, Michael A Smit, Roger Garcia, James K Todd
INTRODUCTION: It is important for clinicians to recognize the contribution of toxic shock syndrome (TSS) to the overall burden of pediatric septic shock because the clinical features, optimal therapy and prognosis differ from non-TSS septic shock. METHODS: We analyzed cases of pediatric septic shock reported to the Pediatric Health Information Systems (PHIS) database between 2009 and 2013 to define the clinical and demographic characteristics of pediatric TSS in the US...
March 27, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29580730/risk-factors-for-repeat-surgical-intervention-in-pediatric-nephrolithiasis-a-pediatric-health-information-system-database-study
#7
Jonathan S Ellison, Margarett Shnorhavorian, Assaf Oron, Kathleen Kieran, Thomas S Lendvay, Paul A Merguerian
INTRODUCTION: Successful surgical therapy for pediatric upper urinary tract calculi (UUTC) minimizes the need for repeat surgical interventions. However, staged procedures, whether planned or unplanned, are sometimes necessary. We assessed predictors of repeat intervention for children with UUTC using a nationwide administrative dataset. METHODS: Using the Pediatric Health Information System (PHIS) dataset, we assessed children with UUTC undergoing shock wave lithotripsy (SWL) or ureteroscopy (URS) for an index stone from January 2010 to June 2015...
March 16, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29579354/penetrating-head-injuries-in-children-presenting-to-the-emergency-department-in-australia-and-new-zealand-a-predict-prospective-study
#8
Franz E Babl, Mark D Lyttle, Silvia Bressan, Meredith L Borland, Natalie Phillips, Amit Kochar, Sarah Dalton, John A Cheek, Yuri Gilhotra, Jeremy Furyk, Jocelyn Neutze, Susan Donath, Stephen Hearps, Marta Arpone, Louise Crowe, Stuart R Dalziel, Ruth Barker, Ed Oakley
AIM: Penetrating head injuries (pHIs) are associated with high morbidity and mortality. Data on pHIs in children outside North America are limited. We describe the mechanism of injuries, neuroimaging findings, neurosurgery and mortality for pHIs in Australia and New Zealand. METHODS: This was a planned secondary analysis of a prospective observational study of children <18 years who presented with a head injury of any severity at any of 10 predominantly paediatric Australian/New Zealand emergency departments (EDs) between 2011 and 2014...
March 26, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29432988/dual-responsive-polyplexes-with-enhanced-disassembly-and-endosomal-escape-for-efficient-delivery-of-sirna
#9
Jia Zhu, Mingxi Qiao, Qi Wang, Yuqing Ye, Shuang Ba, Jingjing Ma, Haiyang Hu, Xiuli Zhao, Dawei Chen
Despite the extracellular barriers for siRNA delivery have been overcome by utilizing advanced nanoparticle delivery systems, the key intracellular barriers after internalization including efficient disassembly of siRNA and endosomal escape still remains challenging. To address the issues, we developed a unique pH- and redox potential-responsive polyplex delivery system based on the copolymer of mPEG-b-PLA-PHis-ssPEI1.8 k, which is composed of a pH-responsive copolymer of PEG-b-PLA-PHis (Mw 5 k) and a branched PEI (Mw1...
April 2018: Biomaterials
https://www.readbyqxmd.com/read/29382128/hypoxia-inducible-factor-and-its-role-in-the-management-of-anemia-in-chronic-kidney-disease
#10
REVIEW
Joshua M Kaplan, Neeraj Sharma, Sean Dikdan
Hypoxia-inducible factor (HIF) plays a crucial role in the response to hypoxia at the cellular, tissue, and organism level. New agents under development to pharmacologically manipulate HIF may provide new and exciting possibilities in the treatment of anemia of chronic kidney disease (CKD) as well as in multiple other disease states involving ischemia-reperfusion injury. This article provides an overview of recent studies describing current standards of care for patients with anemia in CKD and associated clinical issues, and those supporting the clinical potential for targeting HIF stabilization with HIF prolyl-hydroxylase inhibitors (HIF-PHI) in these patients...
January 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29351184/cleft-palate-repair-does-hospital-case-volume-impact-outcomes-or-cost
#11
Ari M Wes, Daniel Mazzaferro, Sanjay Naran, Scott P Bartlett, Jesse A Taylor
BACKGROUND: How hospital case-volume affects operative outcomes and cost continues to grow in importance. The purpose of this study is to examine the relationship of case volume with operative outcomes and cost in cleft palate repair. METHODS: Subjects undergoing cleft palate repair between 2004 and 2015 were identified in the Pediatric Health Information System (PHIS). Outcomes were compared between two exposure groups, those undergoing treatment at a high-volume institution (>85th percentile; >60 cases per year), and those undergoing treatment at a low-volume institution...
January 12, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29346786/changing-trends-in-brain-imaging-technique-for-pediatric-patients-with-ventriculoperitoneal-shunts
#12
Margaret J Trost, Nathan Robison, Dean Coffey, Mary Rose Mamey, R Aaron Robison
BACKGROUND: Children with ventriculoperitoneal shunts (VPS) undergoing brain computed tomography (CT) for shunt malfunction evaluation are at risk for later malignancy due to radiation exposure. We aimed to determine if and how hospitals have adopted radiation-avoiding magnetic resonance imaging (MRI) techniques. METHODS: We performed a secondary analysis of the Pediatric Health Information System (PHIS) database. Children with VPS presenting to acute wards at 31 PHIS hospitals between January 1, 2007 and January 2, 2015 and receiving noncontrast neuroimaging on day of service 0/1 were included...
2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29341504/a-multi-institutional-analysis-of-children-on-long-term-non-invasive-respiratory-support-and-their-outcomes
#13
Monica L Koncicki, Philip Zachariah, Adam R Lucas, Jeffrey D Edwards
OBJECTIVES: To characterize a multi-institutional cohort of children with chronic respiratory failure that use long-term, non-invasive respiratory support, perform a time-to-event analysis of transitions to transtracheal ventilation and identify factors associated with earlier transition to transtracheal ventilation. STUDY DESIGN: A retrospective cohort study of patients less than 21 years of age with diagnoses associated with chronic respiratory failure and discharged on non-invasive respiratory support was performed using data from the Pediatric Health Information System (PHIS) between 2007 and 2015...
January 17, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29288450/systems-biology-modeling-to-study-pathogen-host-interactions
#14
Müberra Fatma Cesur, Saliha Durmuş
Pathogen-host interactions (PHIs) underlie the process of infection. The systems biology view of the whole PHI system is superior to the investigation of the pathogen or host separately in understanding the infection mechanisms. Especially, the identification of host-oriented drug targets for the next-generation anti-infection therapeutics requires the properties of the host factors targeted by pathogens. Here, we provide an outline of computational analysis of PHI networks, focusing on the properties of the pathogen-targeted host proteins...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29276703/a-framework-for-integrating-qualitative-and-quantitative-data-in-knowledge-attitude-and-practice-studies-a-case-study-of-pesticide-usage-in-eastern-uganda
#15
James Muleme, Clovice Kankya, John C Ssempebwa, Stella Mazeri, Adrian Muwonge
Knowledge, attitude, and practice (KAP) studies guide the implementation of public health interventions (PHIs), and they are important tools for political persuasion. The design and implementation of PHIs assumes a linear KAP relationship, i.e., an awareness campaign results in the desirable societal behavioral change. However, there is no robust framework for testing this relationship before and after PHIs. Here, we use qualitative and quantitative data on pesticide usage to test this linear relationship, identify associated context specific factors as well as assemble a framework that could be used to guide and evaluate PHIs...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29260563/smart-nanoparticles-undergo-phase-transition-for-enhanced-cellular-uptake-and-subsequent-intracellular-drug-release-in-a-tumor-microenvironment
#16
Guihua Ye, Yajun Jiang, Xiaoying Yang, Hongxiang Hu, Beibei Wang, Lu Sun, Victor C Yang, Duxin Sun, Wei Gao
Inefficient cellular uptake and intracellular drug release at the tumor site are two major obstacles limiting the antitumor efficacy of nanoparticle delivery systems. To overcome both problems, we designed a smart nanoparticle that undergoes phase transition in a tumor microenvironment (TME). The smart nanoparticle is generated using a lipid-polypetide hybrid nanoparticle, which comprises a PEGylated lipid monolayer shell and a pH-sensitive hydrophobic poly-l-histidine core and is loaded with the antitumor drug doxorubicin (DOX)...
January 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29240000/complete-versus-staged-repair-for-neonates-with-tetralogy-of-fallot-establishment-and-validation-of-a-cohort-of-2235-patients-using-detailed-surgery-sequence-review-of-health-care-administrative-data
#17
Jill J Savla, Brian T Fisher, Jennifer A Faerber, Yuan-Shung V Huang, Laura Mercer-Rosa
BACKGROUND: The surgical strategy for neonates with tetralogy of Fallot (TOF) consists of complete or staged repair. Assessing the comparative effectiveness of these approaches is facilitated by a large multicenter cohort. We propose a novel process for cohort assembly using the Pediatric Health Information System (PHIS), an administrative database that contains clinical and billing data for inpatient and emergency department stays from tertiary children's hospitals. METHODS: A 4-step process was used to identify neonates with TOF: (1) screen neonates in PHIS with International Classification of Diseases-9 (ICD-9) diagnosis or procedure codes for TOF; (2) include patients with TOF procedures before 30 days of age; (3) exclude patients with missing 2-year follow-up data; (4) analyze patients' 2-year surgery sequence patterns, exclude patients inconsistent with a treatment strategy for TOF, and designate patients as complete or staged repair...
December 12, 2017: Medical Care
https://www.readbyqxmd.com/read/29223439/a-unique-linkage-of-administrative-and-clinical-registry-databases-to-expand-analytic-possibilities-in-pediatric-heart-transplantation-research
#18
MULTICENTER STUDY
Justin Godown, Cary Thurm, Debra A Dodd, Jonathan H Soslow, Brian Feingold, Andrew H Smith, Bret A Mettler, Bryn Thompson, Matt Hall
BACKGROUND: Large clinical, research, and administrative databases are increasingly utilized to facilitate pediatric heart transplant (HTx) research. Linking databases has proven to be a robust strategy across multiple disciplines to expand the possible analyses that can be performed while leveraging the strengths of each dataset. We describe a unique linkage of the Scientific Registry of Transplant Recipients (SRTR) database and the Pediatric Health Information System (PHIS) administrative database to provide a platform to assess resource utilization in pediatric HTx...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29200202/advances-in-development-of-new-tools-for-the-study-of-phosphohistidine
#19
Mehul V Makwana, Richmond Muimo, Richard Fw Jackson
Protein phosphorylation is an important post-translational modification that is an integral part of cellular function. The O-phosphorylated amino-acid residues, such as phosphoserine (pSer), phosphothreonine (pThr) and phosphotyrosine (pTyr), have dominated the literature while the acid labile N-linked phosphorylated amino acids, such as phosphohistidine (pHis), have largely been historically overlooked because of the acidic conditions routinely used in amino-acid detection and analysis. This review highlights some misinterpretations that have arisen in the existing literature, pinpoints outstanding questions and potential future directions to clarify the role of pHis in mammalian signalling systems...
March 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29195181/one-pot-synthesis-of-ph-responsive-charge-switchable-pegylated-nanoscale-coordination-polymers-for-improved-cancer-therapy
#20
Yu Yang, Ligeng Xu, Wenjun Zhu, Liangzhu Feng, Jingjing Liu, Qian Chen, Ziliang Dong, Jiayue Zhao, Zhuang Liu, Meiwan Chen
Nanoscale coordination polymers (NCPs) are promising nanomedicine platforms featured with biodegradability and versatile functionalities. However, multi-step post-synthesis surface modification is usually required to functionalize as-made NCPs before their biomedical applications. Moreover, efforts are still required to design therapeutic NCPs responsive to the unique tumor microenvironment to achieve more specific and effective therapy. Herein, we uncover a simple yet general strategy to synthesize a series of polyethylene glycol (PEG) modified NCPs via a one-step method by adding poly-histidine-PEG co-polymer into the mixture of metal ions and organic ligands during NCPs formation...
February 2018: Biomaterials
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