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Guang-Ming Tan, Bryan P Yan
Colchicine is a well-established drug approved by the Food and Drug Administration (FDA) for the prevention and treatment of gout. It processes unique anti-inflammatory properties. Interests in the usage of colchicine in cardiovascular medicine have been rekindled recently with several large trials been carried out to investigate its efficacy in treatment of various cardiac conditions including pericarditis, postpericardiotomy syndrome, atrial fibrillation and coronary artery disease. In this review, the basic pharmacological properties of colchicine will be discussed, and the evidences of its benefits for different applications in cardiovascular medicine will be reviewed...
October 13, 2016: Current Cardiology Reviews
Ankit Kumar Sinha, Amit Jose, Arjun Khanna, Deepak Talwar
No abstract text is available yet for this article.
September 2016: Lung India: Official Organ of Indian Chest Society
Massimo Imazio, Antonio Brucato, Nikki Pluymaekers, Luciana Breda, Giovanni Calabri, Luca Cantarini, Rolando Cimaz, Filomena Colimodio, Fabrizia Corona, Davide Cumetti, Chiara Di Blasi Lo Cuccio, Marco Gattorno, Antonella Insalaco, Giuseppe Limongelli, Maria Giovanna Russo, Anna Valenti, Yaron Finkelstein, Alberto Martini
OBJECTIVE: Limited data are available about recurrent pericarditis in children. We sought to explore contemporary causes, characteristics, therapies and outcomes of recurrent pericarditis in paediatric patients. METHODS: A multicentre (eight sites) cohort study of 110 consecutive cases of paediatric patients with at least two recurrences of pericarditis over an 11-year period (2000-2010) [median 13 years, interquartile range (IQR) 5, 69 boys]. RESULTS: Recurrences were idiopathic or viral in 89...
September 2016: Journal of Cardiovascular Medicine
U Sevuk, E Baysal, R Altindag, B Yaylak, M S Adiyaman, N Ay, U Beyazit, V Alp
OBJECTIVE: Postpericardiotomy syndrome (PPS) occurs in 10-40% of patients after cardiac operations. Pericardial effusions and tamponade occurring > 7 days after surgery are usually related to PPS and remain an important cause of cardiac surgery-related morbidity and mortality; therefore, preventing PPS is important. Colchicine affords safe and efficacious protection against PPS and related complications. However, the roles of corticosteroids and nonsteroidal anti-inflammatory drugs in PPS prevention remains unclear...
2016: European Review for Medical and Pharmacological Sciences
Stephen Bujarski, Elizabeth Guy
Pleural effusion secondary to postpericardiotomy syndrome (PPS) is a relatively common complication after cardiac surgery. These effusions and syndrome complex usually respond well to anti-inflammatory agents. The use of indwelling pleural catheter (IPC) for nonmalignant recurrent pleural effusions is growing. We report the use of IPC for a case of recurrent pleural effusion due to PPS in a gentleman that could not tolerate anti-inflammatory medications. To our knowledge, there has been no other report of the use of IPC due to recurrent pleural effusion from PPS...
April 2016: Journal of Bronchology & Interventional Pulmonology
Utkan Sevuk, Erkan Baysal, Rojhat Altindag, Baris Yaylak, Mehmet Sahin Adiyaman, Nurettin Ay, Vahhac Alp, Unal Beyazit
OBJECTIVE: Postpericardiotomy syndrome (PPS), which is thought to be related to autoimmune phenomena, represents a common postoperative complication in cardiac surgery. Late pericardial effusions after cardiac surgery are usually related to PPS and can progress to cardiac tamponade. Preventive measures can reduce postoperative morbidity and mortality related to PPS. In a previous study, diclofenac was suggested to ameliorate autoimmune diseases. The aim of this study was to determine whether postoperative use of diclofenac is effective in preventing early PPS after cardiac surgery...
2015: Vascular Health and Risk Management
Kevin L Greason
No abstract text is available yet for this article.
May 2015: Journal of Thoracic and Cardiovascular Surgery
Rajendrakumar C Patel, Hemant Goyal, Ahmed I Shah, Jalal K Ghali
INTRODUCTION: Postpericardiotomy syndrome (PPS) is an inflammatory process, affecting 15% to 20% of patients, after surgery involving pleura, pericardium, or both. The role of electrocardiogram (ECG) in diagnosing PPS is uncertain because ECG is rarely normal (especially after cardiac surgery). We report a case of PPS that presented initially with localized ST-segment elevation and also discuss proposed mechanisms. CLINICAL CASE: A 60-year-old White man presented to the emergency department (ED) after having chest pain, shortness of breath, and palpitation for approximately 2 hours...
August 2015: American Journal of Emergency Medicine
Joonas Lehto, Jarmo Gunn, Pasi Karjalainen, Juhani Airaksinen, Tuomas Kiviniemi
OBJECTIVES: Postpericardiotomy syndrome is a well-known complication after cardiac surgery. Nevertheless, little is known about the incidence and predictors of postpericardiotomy syndrome requiring medical attention or hospitalization in a contemporary set of patients undergoing isolated coronary bypass. METHODS: This retrospective analysis included 688 patients from 2008 to 2010. The median follow-up time was 5.3 [4.5-6.0] years. RESULTS: The incidence of postpericardiotomy syndrome was 61 of 688 patients (8...
May 2015: Journal of Thoracic and Cardiovascular Surgery
Hawa Edriss, Jessica Lorenzana, Kenneth Nugent
No abstract text is available yet for this article.
May 2015: American Journal of the Medical Sciences
Maria Jaworska-Wilczyńska, Adriana Magalska, Katarzyna Piwocka, Piotr Szymański, Mariusz Kuśmierczyk, Maria Wąsik, Tomasz Hryniewiecki
AIMS: The objective of this study was to investigate inflammatory markers of the postpericardiotomy syndrome (PPS) and to determine individuals prone to develop the PPS. METHODS AND RESULTS: The study included 75 patients with a stable coronary disease that had underwent coronary artery bypass surgery. Serum samples were collected prior to the surgery and on the 5th day after the operation, to measure the concentration of IL-8, IL-6, IL-1β, IL-10, TNF, IL-12p70...
2014: PloS One
M Chadi Alraies, Wael Al Jaroudi, Cyrus Shabrang, Hirad Yarmohammadi, Allan L Klein, Balaji K Tamarappoo
Postpericardiotomy syndrome (PPS) may be associated with tamponade and pericardial constriction that may require procedural intervention. The aim of this study was to identify clinical features associated with adverse events requiring procedural intervention in patients with PPS. A total of 239 patients who developed PPS after cardiac surgery were monitored for 12 months. PPS was diagnosed if 2 of the 5 following findings were present: fever without infection, pleuritic pain, friction rub, pleural effusion, and pericardial effusion (<60 days after surgery)...
November 1, 2014: American Journal of Cardiology
M Rosa del Fresno, Julio E Peralta, Miguel Ángel Granados, Eugenia Enríquez, Nerea Domínguez-Pinilla, Jaime de Inocencio
Recurrent pericarditis is a troublesome complication of idiopathic acute pericarditis and occurs more frequently in pediatric patients after cardiac surgery (postpericardiotomy syndrome). Conventional treatment with nonsteroidal antiinflammatory drugs, corticosteroids, and colchicine is not always effective or may cause serious adverse effects. There is no consensus, however, on how to proceed in those patients whose disease is refractory to conventional therapy. In such cases, human intravenous immunoglobulin, immunosuppressive drugs, and biological agents have been used...
November 2014: Pediatrics
João H Duarte
No abstract text is available yet for this article.
November 2014: Nature Reviews. Cardiology
Ville Kytö, Jussi Sipilä, Päivi Rautava
BACKGROUND: The clinical profile with regard to sex and the influences on outcomes in patients who have been hospitalized for acute pericarditis is largely uncharacterized. METHODS AND RESULTS: We studied all patients aged ≥16 years admitted to the hospital because of acute pericarditis (postpericardiotomy and myocardial infarction associated pericarditis were excluded). Data were collected from a Finnish national registry that included data on all cardiovascular admissions (670 409) during 9...
October 28, 2014: Circulation
Massimo Imazio, Antonio Brucato, Paolo Ferrazzi, Alberto Pullara, Yehuda Adler, Alberto Barosi, Alida L Caforio, Roberto Cemin, Fabio Chirillo, Chiara Comoglio, Diego Cugola, Davide Cumetti, Oleksandr Dyrda, Stefania Ferrua, Yaron Finkelstein, Roberto Flocco, Anna Gandino, Brian Hoit, Francesco Innocente, Silvia Maestroni, Francesco Musumeci, Jae Oh, Amedeo Pergolini, Vincenzo Polizzi, Arsen Ristic, Caterina Simon, David H Spodick, Vincenzo Tarzia, Stefania Trimboli, Anna Valenti, Riccardo Belli, Fiorenzo Gaita
IMPORTANCE: Postpericardiotomy syndrome, postoperative atrial fibrillation (AF), and postoperative effusions may be responsible for increased morbidity and health care costs after cardiac surgery. Postoperative use of colchicine prevented these complications in a single trial. OBJECTIVE: To determine the efficacy and safety of perioperative use of oral colchicine in reducing postpericardiotomy syndrome, postoperative AF, and postoperative pericardial or pleural effusions...
September 10, 2014: JAMA: the Journal of the American Medical Association
Chanu Rhee, Paul Edward Sax
Fever following cardiac surgery is common and may be infectious or noninfectious in etiology. In this article, we review the major causes of postoperative fever while highlighting special considerations in cardiac surgery patients. We also outline a structured approach to evaluation and present an overview of diagnostic and management considerations for mediastinitis, postpericardiotomy syndrome, prosthetic valve endocarditis, aortic vascular graft infections, and ventricular assist device infections.
June 2015: Seminars in Cardiothoracic and Vascular Anesthesia
Jeroen J H Bunge, Dirk van Osch, Jan M Dieleman, Kirolos A Jacob, Jolanda Kluin, Diederik van Dijk, Hendrik M Nathoe
BACKGROUND: The postpericardiotomy syndrome (PPS) is a common complication following cardiac surgery. The pathophysiology remains unclear, although evidence exists that surgical trauma and the use of cardiopulmonary bypass provoke an immune response leading to PPS. We hypothesized that an intraoperative dose of dexamethasone decreases the risk of PPS, by reducing this inflammatory response. METHODS: We performed a subanalysis of the DECS study, which is a multicenter, double-blind, placebo-controlled, randomized trial of 4,494 patients undergoing cardiac surgery with use of cardiopulmonary bypass...
July 2014: American Heart Journal
Massimiliano Cantinotti, Isabella Spadoni, Nadia Assanta, Maura Crocetti, Marco Marotta, Luigi Arcieri, Bruno Murzi, Massimo Imazio
Postsurgical pericardial syndromes are common complications after cardiac surgery; however, their treatment is not well established yet. We reviewed the accuracy and limits of clinical trials of prophylaxis and treatment of these diseases to identify an evidence-based therapeutic approach. We performed a literature search in the National Library of Medicine using the keywords pericardial effusion, cardiac surgery and paediatric/congenital. The research was then redefined adding separately the keywords postpericardiotomy syndrome, NSAIDs, steroids and colchicine...
December 2014: Journal of Cardiovascular Medicine
Massimo Imazio, Riccardo Belli, Antonio Brucato, Paolo Ferrazzi, Davide Patrini, Luigi Martinelli, Vincenzo Polizzi, Roberto Cemin, Anna Leggieri, Alida L P Caforio, Yaron Finkelstein, Brian Hoit, Bernhard Maisch, Bongani M Mayosi, Jae K Oh, Arsen D Ristic, Petar Seferovic, David H Spodick, Yehuda Adler
BACKGROUND: The efficacy and safety of colchicine for the primary prevention of the postpericardiotomy syndrome (PPS), postoperative effusions, and postoperative atrial fibrillation (POAF) remain uncertain. Although preliminary data from a single trial of colchicine given for 1 month postoperatively (COPPS trial) were promising, the results have not been confirmed in a large, multicenter trial. Moreover, in the COPPS trial, colchicine was given 3 days postoperatively. METHODS: The COPPS-2 study is a multicenter, double-blind, placebo-controlled randomized trial...
July 2013: American Heart Journal
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