keyword
MENU ▼
Read by QxMD icon Read
search

Stroke, brain, behavior

keyword
https://www.readbyqxmd.com/read/28431032/neuropsychology-and-rehabilitation-services-in-the-united-states-brief-report-from-a-survey-of-clinical-neuropsychologists
#1
Cady Block, Octavio A Santos, Yvonne Flores-Medina, Diego Fernando Rivera Camacho, Juan Carlos Arango-Lasprilla
Objective: To provide a brief presentation of preliminary data on rehabilitation services provided by clinical neuropsychologists within the United States. Method: This survey utilized data extracted from a larger international research study conducted in 39 countries including N = 173 professionals who reported to engage in neuropsychological rehabilitative services within the past year (63.6% female, 44.36 ± 11.83 years of age) took part in the study. Results: Neuropsychologists providing rehabilitation services in the United States in the past year were more likely to provide individual versus group therapy, likely to employ technology (e...
May 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28430000/neuroprotective-and-regenerative-roles-of-intranasal-wnt-3a-administration-after-focal-ischemic-stroke-in-mice
#2
Zheng Zachory Wei, James Ya Zhang, Tammi M Taylor, Xiaohuan Gu, Yingying Zhao, Ling Wei
Wnt signaling is a conserved pathway involved in expansion of neural progenitors and lineage specification during development. However, the role of Wnt signaling in the post-stroke brain has not been well-elucidated. We hypothesized that Wnt-3a would play an important role for neurogenesis and brain repair. Adult male mice were subjected to a focal ischemic stroke targeting the sensorimotor cortex. Mice that received Wnt-3a (2 µg/kg/day, 1 h after stroke and once a day for the next 2 days, intranasal delivery) had reduced infarct volume compared to stroke controls...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28420282/exploring-predictors-of-treatment-outcome-in-cognitive-behavior-therapy-for-sleep-disturbance-following-acquired-brain-injury
#3
Sylvia Nguyen, Dean McKenzie, Adam McKay, Dana Wong, Shantha M W Rajaratnam, Gershon Spitz, Gavin Williams, Darren Mansfield, Jennie Ponsford
PURPOSE: To identify predictors of treatment response to cognitive behavior therapy (CBT) for sleep disturbance following acquired brain injury (ABI). METHODS: Classification and regression tree (CART) analysis was conducted on individual patient data from two pilot randomized controlled trials (RCTs): one in traumatic brain injury (TBI), the other in stroke. The combined sample comprised 32 participants; 15 receiving CBT and 17 allocated to treatment as usual (TAU)...
April 19, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28419682/game-theoretical-mapping-of-causal-interactions-underlying-visuo-spatial-attention-in-the-human-brain-based-on-stroke-lesions
#4
Monica N Toba, Melissa Zavaglia, Federica Rastelli, Romain Valabrégue, Pascale Pradat-Diehl, Antoni Valero-Cabré, Claus C Hilgetag
Anatomical studies conducted in neurological conditions have developed our understanding of the causal relationships between brain lesions and their clinical consequences. The analysis of lesion patterns extended across brain networks has been particularly useful in offering new insights on brain-behavior relationships. Here we applied multiperturbation Shapley value Analysis (MSA), a multivariate method based on coalitional game theory inferring causal regional contributions to specific behavioral outcomes from the characteristic functional deficits after stroke lesions...
April 17, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28400817/nonhuman-primate-models-of-focal-cerebral-ischemia
#5
REVIEW
Jingjing Fan, Yi Li, Xinyu Fu, Lijuan Li, Xiaoting Hao, Shasha Li
Rodents have been widely used in the production of cerebral ischemia models. However, successful therapies have been proven on experimental rodent stroke model, and they have often failed to be effective when tested clinically. Therefore, nonhuman primates were recommended as the ideal alternatives, owing to their similarities with the human cerebrovascular system, brain metabolism, grey to white matter ratio and even their rich behavioral repertoire. The present review is a thorough summary of ten methods that establish nonhuman primate models of focal cerebral ischemia; electrocoagulation, endothelin-1-induced occlusion, microvascular clip occlusion, autologous blood clot embolization, balloon inflation, microcatheter embolization, coil embolization, surgical suture embolization, suture, and photochemical induction methods...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28393932/anti-high-mobility-group-box-1-hmgb1-antibody-inhibits-hemorrhage-induced-brain-injury-and-improved-neurological-deficits-in-rats
#6
Dengli Wang, Keyue Liu, Hidenori Wake, Kiyoshi Teshigawara, Shuji Mori, Masahiro Nishibori
As one of the most lethal stroke subtypes, intracerebral hemorrhage (ICH) is acknowledged as a serious clinical problem lacking effective treatment. Available evidence from preclinical and clinical studies suggests that inflammatory mechanisms are involved in the progression of ICH-induced secondary brain injury. High mobility group box-1 (HMGB1) is a ubiquitous and abundant nonhistone DNA-binding protein, and is also an important proinflammatory molecule once released into the extracellular space from the nuclei...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28389473/st2-il-33-dependent-microglial-response-limits-acute-ischemic-brain-injury
#7
Yuanyuan Yang, Huan Liu, Haiyue Zhang, Qing Ye, Jianyi Wang, Boyu Yang, Leilei Mao, Wen Zhu, Rehana K Leak, Bo Xiao, Binfeng Lu, Jun Chen, Xiaoming Hu
ST2, a member of the interleukin 1 receptor family, and its ligand interleukin 33 (IL-33) play critical roles in immune regulation and inflammatory responses. This study explores the roles of endogenous IL-33/ST2 signaling in ischemic brain injury and elucidates the underlying mechanisms of action. The expression of IL-33 rapidly increased in oligodendrocytes and astrocytes after 60 min transient middle cerebral artery occlusion (tMCAO). ST2 receptor deficiency exacerbated brain infarction 3d after tMCAO as well as distal permanent MCAO...
April 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28382161/edaravone-encapsulated-agonistic-micelles-rescue-ischemic-brain-tissue-by-tuning-blood-brain-barrier-permeability
#8
Qu Jin, Yu Cai, Sihan Li, Haoran Liu, Xingyu Zhou, Chunqiang Lu, Xihui Gao, Jun Qian, Jun Zhang, Shenghong Ju, Cong Li
Thrombolysis has been a standard treatment for ischemic stroke. However, only 2-7% patients benefit from it because the thrombolytic agent has to be injected within 4.5 h after the onset of symptoms to avoid the increasing risk of intracerebral hemorrhage. As the only clinically approved neuroprotective drug, edaravone (EDV) rescues ischemic brain tissues by eradicating over-produced reactive oxygen species (ROS) without the limitation of therapeutic time-window. However, EDV's short circulation half-life and inadequate cerebral uptake attenuate its therapeutic efficacy...
2017: Theranostics
https://www.readbyqxmd.com/read/28363987/progesterone-induced-neuroprotection-in-reperfusion-promoted-mitochondrial-dysfunction-following-focal-cerebral-ischemia-in-rats
#9
Syed Suhail Andrabi, Suhel Parvez, Heena Tabassum
Alterations in mitochondrial permeability transition and organelle damage are key players in the development of cerebral ischemic tissue injury due to associated modifications in ATP turnover and cellular apoptosis/necrosis. Early restoration of blood flow and improvement of mitochondrial function might reverse the situation and help in recovery following an onset of stroke. Mitochondria and related bioenergetics can be effectively used as pharmacological targets. Progesterone (P4), one of the promising neurosteroids, has been found neuroprotective in various models of neurological diseases through a number of mechanisms...
March 31, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28359729/dl-3-n-butylphthalide-induced-neuroprotection-regenerative-repair-functional-recovery-and-psychological-benefits-following-traumatic-brain-injury-in-mice
#10
Yingying Zhao, Jin Hwan Lee, Dongdong Chen, Xiaohuan Gu, Asha Caslin, Jimei Li, Shan Ping Yu, Ling Wei
Previous investigations suggest that DL-3-n-butylphthalide (NBP) is a promising multifaceted drug for the treatment of stroke. It is not clear whether NBP can treat traumatic brain injury (TBI) and what could be the mechanisms of therapeutic benefits. To address these issues, TBI was induced by a controlled cortical impact in adult male mice. NBP (100 mg/kg) or saline was intraperitoneally administered within 5 min after TBI. One day after TBI, apoptotic events including caspase-3/9 activation, cytochrome c release from the mitochondria, and apoptosis-inducing factor (AIF) translocation into the nucleus in the pericontusion region were attenuated in NBP-treated mice compared to TBI-saline controls...
March 28, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28345282/neuroplasticity-of-language-in-left-hemisphere-stroke-evidence-linking-subsecond-electrophysiology-and-structural-connections
#11
Vitória Piai, Lars Meyer, Nina F Dronkers, Robert T Knight
The understanding of neuroplasticity following stroke is predominantly based on neuroimaging measures that cannot address the subsecond neurodynamics of impaired language processing. We combined behavioral and electrophysiological measures and structural-connectivity estimates to characterize neuroplasticity underlying successful compensation of language abilities after left-hemispheric stroke. We recorded the electroencephalogram from patients with stroke lesions to the left temporal lobe and from matched controls during context-driven word retrieval...
March 27, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28334392/validation-of-the-nih-toolbox-in-individuals-with-neurologic-disorders
#12
N E Carlozzi, S Goodnight, K B Casaletto, A Goldsmith, R K Heaton, A W K Wong, C M Baum, R Gershon, A W Heinemann, D S Tulsky
Objective: Individuals with spinal cord injury (SCI), traumatic brain injury (TBI), and stroke experience a variety of neurologically related deficits across multiple domains of function. The NIH Toolbox for the Assessment of Neurological and Behavioral Function (NIHTB) examines motor, sensation, cognition, and emotional functioning. The purpose of this paper is to establish the validity of the NIHTB in individuals with neurologic conditions. Methods: Community-dwelling individuals with SCI (n = 209), TBI (n = 184), or stroke (n = 211) completed the NIHTB...
March 18, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28317276/important-considerations-in-lesion-symptom-mapping-illustrations-from-studies-of-word-comprehension
#13
Hinna Shahid, Rajani Sebastian, Tatiana T Schnur, Taylor Hanayik, Amy Wright, Donna C Tippett, Julius Fridriksson, Chris Rorden, Argye E Hillis
Lesion-symptom mapping is an important method of identifying networks of brain regions critical for functions. However, results might be influenced substantially by the imaging modality and timing of assessment. We tested the hypothesis that brain regions found to be associated with acute language deficits depend on (1) timing of behavioral measurement, (2) imaging sequences utilized to define the "lesion" (structural abnormality only or structural plus perfusion abnormality), and (3) power of the study. We studied 191 individuals with acute left hemisphere stroke with MRI and language testing to identify areas critical for spoken word comprehension...
March 20, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28317235/astrocyte-specific-insulin-like-growth-factor-1-gene-transfer-in-aging-female-rats-improves-stroke-outcomes
#14
Andre K Okoreeh, Shameena Bake, Farida Sohrabji
Middle aged female rats sustain larger stroke infarction and disability than younger female rats. This older group also shows age-related reduction of insulin like growth factor (IGF)-1 in serum and in astrocytes, a cell type necessary for poststroke recovery. To determine the impact of astrocytic IGF-1 for ischemic stroke, these studies tested the hypothesis that gene transfer of IGF-1 to astrocytes will improve stroke outcomes in middle aged female rats. Middle aged (10-12 month old), acyclic female rats were injected with recombinant adeno-associated virus serotype 5 (AAV5) packaged with the coding sequence of the human (h)IGF-1 gene downstream of an astrocyte-specific promoter glial fibrillary acidic protein (GFAP) (AAV5-GFP-hIGF-1) into the striatum and cortex...
March 20, 2017: Glia
https://www.readbyqxmd.com/read/28315758/tat-pep-a-novel-blocker-of-pirb-enhances-the-recovery-of-cognitive-function-in-mice-after-transient-global-cerebral-ischemia
#15
Liya Li, Bin Deng, Shuang Li, Zhaoyu Liu, Tao Jiang, Zhaoyang Xiao, Qiang Wang
Neuronal damage and axonal regeneration inhibition are the main reasons to poor functional recovery after ischemia. Nogo-A signals inhibit axon outgrowth through the PirB receptor after ischemic reperfusion injury in central nervous system. We use TAT-PEP, a novel protein which could pass through the blood brain barrier, to block the function of PirB and identify the long-term neurological and behavioral recovery after bilateral common carotid artery occlusion (BCCAO) in mice. We observed that TAT-PEP promoted neuron survival and inhibited neuronal apoptosis...
March 16, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28290150/extracellular-matrix-modulation-is-driven-by-experience-dependent-plasticity-during-stroke-recovery
#16
Miriana Jlenia Quattromani, Mathilde Pruvost, Carla Guerreiro, Fredrik Backlund, Elisabet Englund, Anders Aspberg, Tomasz Jaworski, Jakob Hakon, Karsten Ruscher, Leszek Kaczmarek, Denis Vivien, Tadeusz Wieloch
Following stroke, complete cellular death in the ischemic brain area may ensue, with remaining brain areas undergoing tissue remodelling to various degrees. Experience-dependent brain plasticity exerted through an enriched environment (EE) promotes remodelling after central nervous system injury, such as stroke. Post-stroke tissue reorganization is modulated by growth inhibitory molecules differentially expressed within the ischemic hemisphere, like chondroitin sulfate proteoglycans found in perineuronal nets (PNNs)...
March 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28279192/stroke-alters-behavior-of-human-skin-derived-neural-progenitors-after-transplantation-adjacent-to-neurogenic-area-in-rat-brain
#17
Carlos de la Rosa-Prieto, Cecilia Laterza, Ana Gonzalez-Ramos, Somsak Wattananit, Ruimin Ge, Olle Lindvall, Daniel Tornero, Zaal Kokaia
BACKGROUND: Intracerebral transplantation of human induced pluripotent stem cells (iPSCs) can ameliorate behavioral deficits in animal models of stroke. How the ischemic lesion affects the survival of the transplanted cells, their proliferation, migration, differentiation, and function is only partly understood. METHODS: Here we have assessed the influence of the stroke-induced injury on grafts of human skin iPSCs-derived long-term neuroepithelial-like stem cells using transplantation into the rostral migratory stream (RMS), adjacent to the neurogenic subventricular zone, in adult rats as a model system...
March 9, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28278592/exploring-associations-between-self-regulatory-mechanisms-and-neuropsychological-functioning-and-driver-behaviour-after-brain-injury
#18
Per-Ola Rike, Hans J Johansen, Pål Ulleberg, Anna Lundqvist, Anne-Kristine Schanke
The objective of this prospective one-year follow-up study was to explore the associations between self-regulatory mechanisms and neuropsychological tests as well as baseline and follow-up ratings of driver behaviour. The participants were a cohort of subjects with stroke and traumatic brain injury (TBI) who were found fit to drive after a multi-disciplinary driver assessment (baseline). Baseline measures included neuropsychological tests and ratings of self-regulatory mechanisms, i.e., executive functions (Behavior Rating Inventory of Executive Function-Adult Version; BRIEF-A) and impulsive personality traits (UPPS Impulsive Behavior Scale)...
April 11, 2016: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28255345/a-specific-dietary-intervention-to-restore-brain-structure-and-function-after-ischemic-stroke
#19
Maximilian Wiesmann, Bastian Zinnhardt, Dirk Reinhardt, Sarah Eligehausen, Lydia Wachsmuth, Sven Hermann, Pieter J Dederen, Marloes Hellwich, Michael T Kuhlmann, Laus M Broersen, Arend Heerschap, Andreas H Jacobs, Amanda J Kiliaan
Occlusion of the middle cerebral artery (MCAo) is among the most common causes of ischemic stroke in humans. Cerebral ischemia leads to brain lesions existing of an irreversibly injured core and an ischemic boundary zone, the penumbra, containing damaged but potentially salvageable tissue. Using a transient occlusion (30 min) of the middle cerebral artery (tMCAo) mouse model in this cross-institutional study we investigated the neurorestorative efficacy of a dietary approach (Fortasyn) comprising docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium as therapeutic approach to counteract neuroinflammation and impairments of cerebral (structural+functional) connectivity, cerebral blood flow (CBF), and motor function...
2017: Theranostics
https://www.readbyqxmd.com/read/28250753/breviscapine-reduces-neuronal-injury-caused-by-traumatic-brain-injury-insult-partly-associated-with-suppression-of-interleukin-6-expression
#20
Ling Jiang, Yue Hu, Xiang He, Qiang Lv, Ting-Hua Wang, Qing-Jie Xia
Breviscapine, extracted from the herb Erigeron breviscapus, is widely used for the treatment of cardiovascular diseases, cerebral infarct, and stroke, but its mechanism of action remains unclear. This study established a rat model of traumatic brain injury induced by controlled cortical impact, and injected 75 μg breviscapine via the right lateral ventricle. We found that breviscapine significantly improved neurobehavioral dysfunction at 6 and 9 days after injection. Meanwhile, interleukin-6 expression was markedly down-regulated following breviscapine treatment...
January 2017: Neural Regeneration Research
keyword
keyword
6959
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"