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https://www.readbyqxmd.com/read/28918462/development-of-a-new-scoring-system-to-predict-5-year-incident-diabetes-risk-in-middle-aged-and-older-chinese
#1
Xu Han, Jing Wang, Yaru Li, Hua Hu, Xiulou Li, Jing Yuan, Ping Yao, Xiaoping Miao, Sheng Wei, Youjie Wang, Yuan Liang, Xiaomin Zhang, Huan Guo, An Pan, Handong Yang, Tangchun Wu, Meian He
AIMS: The aim of this study was to develop a new risk score system to predict 5-year incident diabetes risk among middle-aged and older Chinese population. METHODS: This prospective study included 17,690 individuals derived from the Dongfeng-Tongji cohort. Participants were recruited in 2008 and were followed until October 2013. Incident diabetes was defined as self-reported clinician diagnosed diabetes, fasting glucose ≥7.0 mmol/l, or the use of insulin or oral hypoglycemic agent...
September 16, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28912194/assessing-oral-medication-adherence-among-patients-with-type-2-diabetes-mellitus-treated-with-polytherapy-in-a-developed-asian-community-a-cross-sectional-study
#2
Cia Sin Lee, Jane Hwee Mian Tan, Usha Sankari, Yi Ling Eileen Koh, Ngiap Chuan Tan
OBJECTIVES: The disease burden of type 2 diabetes mellitus (T2DM) is rising due to suboptimal glycaemic control leading to vascular complications. Medication adherence (MA) directly influences glycaemic control and clinical consequences. This study aimed to assess the MA of patients with T2DM and identify associated factors. DESIGN: Analysis of data from a cross-sectional survey and electronic medical records. SETTING: Primary care outpatient clinic in Singapore...
September 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28904737/anticataractogenesis-and-antiretinopathy-effects-of-the-novel-protective-agent-containing-the-combined-extract-of-mango-and-vietnamese-coriander-in-stz-diabetic-rats
#3
Jintanaporn Wattanathorn, Paphaphat Thiraphatthanavong, Wipawee Thukham-Mee, Supaporn Muchimapura, Panakaporn Wannanond, Terdthai Tong-Un
The novel protectant against diabetic cataract and diabetic retinopathy is currently required due to the increased prevalence and therapeutic limitation. Based on the advantage of polyphenol on diabetic eye complications, we hypothesized that the combined extract of mango seed Vietnamese coriander (MPO), a polyphenol-rich substance, should possess anticataractogenesis and antiretinopathy in streptozotocin- (STZ-) diabetic rats. MPO at doses of 2, 10, and 50 mg/kg·BW were orally given to STZ-diabetic rats for 10 weeks...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28892956/short-term-efficacy-and-safety-of-insulin-glargine-in-type-2-diabetes-inadequately-controlled-with-single-or-two-oral-agents-a-prospective-open-label-study
#4
Ajay Aggarwal, Roopak Wadhwa
INTRODUCTION: Basal insulin is among the second line treatment options for Type 2 Diabetes Mellitus (T2DM). Efficacy and safety of basal insulin in patients of T2DM, uncontrolled with Oral Antidiabetic Agents (OAAs) remains understudied in the Indian setting. AIM: To assess the efficacy and safety of insulin glargine in patients with T2DM who have uncontrolled glycaemic levels despite single or two OAAs therapy. MATERIALS AND METHODS: In this prospective, open label study, T2DM patients above 40 years of age, having inadequate glycaemic control [Glycosylated Haemoglobin (HbA1c) above 8% and/or fasting glucose level of 140 mg/dl and above] with single or two OAAs over three consecutive months were included...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892282/diabetic-foot-infection-antibiotic-therapy-and-good-practice-recommendations
#5
Nicholas D Barwell, Marion C Devers, Brian Kennon, Helen E Hopkinson, Claire McDougall, Matthew J Young, Hannah M A Robertson, Duncan Stang, Stephanie J Dancer, Andrew Seaton, Graham P Leese
BACKGROUND: Healthcare events related to diabetic foot disease carry a burden of morbidity, mortality and economic cost. Prompt identification of clinical infection with appropriate tissue sampling limits use of broad spectrum empirical antibiotics and improves antibiotic stewardship. Staphylococcus aureus remains the commonest infecting organism and high-dose flucloxacillin remains the empirical antibiotic of choice for antibiotic naïve patients. Barriers to microbe-specific treatment include: adequate tissue sampling, delays in culture results, drug allergies and the emergence of multidrug-resistant organisms which can complicate the choice of targeted antibiotics...
September 11, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28891142/network-meta-analysis-of-lorcaserin-and-oral-hypoglycaemics-for-patients-with-type-2-diabetes-mellitus-and-obesity
#6
L M Neff, M S Broder, D Beenhouwer, E Chang, E Papoyan, Z W Wang
In addition to weight loss, randomized controlled trials have shown improvement in glycaemic control in patients taking lorcaserin. The aim of this study aim was to compare adding lorcaserin or other glucose lowering medications to metformin on weight and glycaemic control. A systematic review and network meta-analysis of randomized controlled trials were conducted. Included studies (published 1990-2014) were of lorcaserin or glucose lowering medications in type 2 diabetic patients compared to placebo or different active treatments...
September 10, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28890943/trial-of-amiloride-in-type-2-diabetes-with-proteinuria
#7
Mark L Unruh, V Shane Pankratz, John E Demko, Evan C Ray, Rebecca P Hughey, Thomas R Kleyman
INTRODUCTION: Renal Na(+) retention and extracellular fluid volume expansion are hallmarks of nephrotic syndrome, which occurs even in the absence of activation of hormones that stimulate renal Na(+) transporters. Plasmin-dependent activation of the epithelial Na(+) channel (ENaC) has been proposed to have a role in renal Na(+) retention in the setting of nephrotic syndrome. We hypothesized that the ENaC inhibitor amiloride would be an effective therapeutic agent in inducing a natriuresis and lowering blood pressure in individuals with macroscopic proteinuria...
September 2017: KI Reports
https://www.readbyqxmd.com/read/28883231/the-assessment-of-the-efficacy-of-dipeptidyl-peptidase-4-inhibitors-in-patients-with-glucocorticoid-induced-diabetes-by-continuous-glucose-monitoring
#8
Yusuke Yata, Michihiro Hosojima, Hideyuki Kabasawa, Tomomi Ishikawa, Ryohei Kaseda, Noriaki Iino, Yoshiki Suzuki, Akihiko Saito, Ichiei Narita
Objective The administration of glucocorticoids usually causes a mild increase in fasting glucose levels and a greater dose-dependent increase in postprandial values in patients without pre-existing diabetes mellitus. Patients with persistent hyperglycemia due to glucocorticoid therapy sometimes require insulin therapy, which might result in increased weight gain and more episodes of hypoglycemia, some of which are severe. On the other hand, scant evidence is available on the efficacy of oral hypoglycemic agents in treating glucocorticoid-induced diabetes...
September 6, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28868582/still-sour-about-lactic-acidosis-years-later-role-of-metformin-in-heart-failure
#9
REVIEW
William Kuan, Craig J Beavers, Maya E Guglin
Metformin remains a widely-used, first-line pharmacotherapy agent for patients with type 2 diabetes mellitus because of its efficacy, mild side effects, and affordability.However, use of this medication has traditionally been shunned by clinicians in patient populations that are considered at risk of lactic acidosis, such as those with heart failure. The underutilization of metformin can largely be attributed to the historical stigma of its biguanide predecessor, phenformin, and its association with lactic acidosis...
September 4, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28864375/metformin-use-and-vitamin-b12-deficiency-untangling-the-association
#10
René Rodríguez-Gutiérrez, Juan Montes-Villarreal, Karla Victoria Rodríguez-Velver, Camilo González-Velázquez, Alejandro Salcido-Montenegro, Anasofia Elizondo-Plazas, José Gerardo González-González
BACKGROUND: Current evidence linking vitamin B12 deficiency with metformin use is inconsistent. Hence, there is uncertainty regarding the diagnostic approach in this scenario. Furthermore, this possible association has not been studied in the complete spectrum of patients with diabetes. MATERIALS AND METHODS: We conducted a cross-sectional, controlled study with the objective of assessing differences in serum vitamin B12 levels among patients with and without diabetes with different metformin-treatment regimens...
August 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28861952/use-of-sodium-glucose-cotransporter%C3%A2-2-inhibitors-in-older-patients-with-type%C3%A2-2-diabetes-mellitus
#11
Takahiro Kambara, Rei Shibata, Hiroyuki Osanai, Yoshihito Nakashima, Hiroshi Asano, Kazuyoshi Sakai, Toyoaki Murohara, Masayoshi Ajioka
AIM: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are antidiabetic agents that act on the proximal renal tubules to lower blood glucose levels by inhibiting glucose reabsorption and promoting urinary glucose excretion. The present study assessed the long-term use of SGLT2 inhibitors in older patients with diabetes. METHODS: A total of 117 older patients with type 2 diabetes who were given SGLT2 inhibitors were enrolled from April 2014 to March 2016. RESULTS: The mean age of the patients was 73...
September 1, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28858729/effect-of-zinc-gluconate-sage-oil-on-inflammatory-patterns-and-hyperglycemia-in-zinc-deficient-diabetic-rats
#12
Mohamed M Elseweidy, Abdel-Moniem A Ali, Nabila Zein Elabidine, Nada M Mursey
BACKGROUND: The relationship between zinc homeostasis and pancreatic function had been established. In this study we aimed firstly to configure the inflammatory pattern and hyperglycemia in zinc deficient diabetic rats. Secondly to illustrate the effect of two selected agents namely Zinc gluconate and sage oil (Salvia Officinalis, family Lamiaceae). METHODS: Rats were fed on Zinc deficient diet, deionized water for 28days along with Zinc level check up at intervals to achieve zinc deficient state then rats were rendered diabetic through receiving one dose of alloxan monohydrate (120mg/kg) body weight, classified later into 5 subgroups...
August 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28858079/laparoscopic-vertical-sleeve-gastrectomy-a-5-year-veterans-affairs-review
#13
Rahman G Barry, Farzad A Amiri, Todd W Gress, D Blaine Nease, Timothy D Canterbury
The aim of this study was to evaluate the outcomes after laparoscopic sleeve gastrectomy (SG) in a VA population.SG has recently gained popularity as a definitive bariatric surgery procedure. Data are lacking on long-term outcomes, particularly in a Veterans Affairs population.We retrospectively reviewed 223 patients who underwent SG for morbid obesity between January 2009 and June 2014. Data on length of stay, complications, interval weight loss, comorbidities, and number of therapies preoperatively and at long-term follow-up were collected...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28856781/cellular-apoptosis-and-cardiac-dysfunction-in-stz-induced-diabetic-rats-attenuated-by-anthocyanins-via-activation-of-igfi-r-pi3k-akt-survival-signaling
#14
Yin-Tso Liu, Pei-Chen Huang, Guei-Jane Wang, Ming-Jen Fan, Marthandam Asokan Shibu, Vijaya Padma Viswanadha, Yi-Lin Lin, Chao-Hung Lai, Yu-Feng Chen, Hung-En Liao, Chih-Yang Huang
Anthocyanins are known cyto-protective agents against various stress conditions. In this study cardio-protective effect of anthocyanins from black rice against diabetic mellitus (DM) was evaluated using a streptozotocin (STZ)-induced DM rat model. Five-week-old male Wistar rats were administered with STZ (55 mg kg(-1) , IP) to induce DM; rats in the treatment group received 250 mg oral anthocyanin/kg/day during the 4-week treatment period. DM and the control rats received normal saline through oral gavage...
August 30, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28855459/background-characteristics-and-clinical-features-of-elderly-patients-with-hyperglycemic-hyperosmolar-syndrome
#15
Takuya Yamaoka, Yoshiaki Tamura, Remi Kodera, Yuki Tsuboi, Ken Sato, Yuko Chiba, Seijiro Mori, Hideki Ito, Atsushi Araki
AIM: Few reports have described the characteristics of hyperglycemic hyperosmolar syndrome (HHS) in the elderly. We investigated the background characteristics and clinical features of 14 elderly patients with HHS. METHODS: HHS was diagnosed based on a blood glucose level of >600 mg/dL and an effective plasma osmolality [2 (Na) + glu/18] of >320 mOsm/kg. For 14 cases of HHS, we investigated the medical and social backgrounds of the patients, their clinical findings, and the outcomes...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/28844525/oral-antidiabetic-agents-and-cardiovascular-outcomes
#16
Manan Pareek, Deepak L Bhatt
Cardiovascular disease is the leading cause of morbidity and mortality among patients with type 2 diabetes; however, a direct protective effect of tight glycemic control remains unproven. In fact, until 2008, when concerns related to rosiglitazone prompted regulatory agencies to mandate assessment of cardiovascular safety of new antidiabetic agents, little was known about how these medications affected cardiovascular outcomes. Since then, there has been a considerable increase in the number of cardiovascular trials, which employ a noninferiority design and focus on high-risk populations to establish safety in the shortest time possible...
July 29, 2017: Current Problems in Cardiology
https://www.readbyqxmd.com/read/28840833/the-anti-inflammatory-and-anti-glycative-effects-of-rosmarinic-acid-in-the-livers-of-type-1-diabetic-mice
#17
Yu-Ju Wen, Mei-Chin Yin
BACKGROUND: Rosmarinic acid (RA) is a polyphenol present in members of the Lamiaceae family. In this study, yhe anti-inflammatory and anti-glycative effects of RA in the livers of type 1 diabetic mice were examined. METHODS: The diabetic mice were divided into three groups: diabetic mice with 0, low dose RA (25 mg/ml), and high dose RA (50 mg/ml). One group of non-diabetic mice was used as a control for comparison. RA was supplied via daily 200 μL oral injections for 9 weeks...
September 2017: BioMedicine
https://www.readbyqxmd.com/read/28840639/use-of-oral-antidiabetic-drugs-in-the-treatment-of-maturity-onset-diabetes-of-the-young-mody-a-minireview
#18
REVIEW
Ludmila Brunerova, Dario Rahelić, Antonio Ceriello, Jan Broz
BACKGROUND: MODY (Maturity-onset diabetes of the young) is a genetically linked group of clinically heterogeneous subtypes of diabetes. Roughly 5% of people with diabetes mellitus diagnosed prior to age 45 have MODY diabetes, the majority of whom have been erroneously diagnosed as patients with either Type 1 or Type 2 diabetes and, as a result, have been improperly treated. Genetic identification of MODY diabetes and its subtypes allows proper treatment and enables clinicians to switch many patients to oral antidiabetic agents, mainly sulphonylureas...
August 24, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28840616/murraya-paniculata-l-orange-jasmine-potential-nutraceuticals-with-ameliorative-effect-in-alloxan-induced-diabetic-rats
#19
Cicero Diego Almino Menezes, Francisca Adilfa de Oliveira Garcia, Glauce Socorro de Barros Viana, Patricia Gonçalves Pinheiro, Cícero Francisco Bezerra Felipe, Thaís Rodrigues de Albuquerque, Alisson Cordeiro Moreira, Enaide Soares Santos, Maynara Rodrigues Cavalcante, Tatiana Rodrigues Garcia, Thiago Fonseca Silva, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes
Orange jasmine, Murraya paniculata (Rutaceae), is a plant from India widely used in folk medicine as antinociceptive, antiinflammatory, and antioxidant. Although oral hypoglycemic agents and insulin are the mainstays of treatment of diabetes mellitus (DM), there is a significant demand for new natural products to reduce the development of diabetic complications. Alloxan-induced diabetic rats were treated for 60 days with a hydroalcoholic extract of M. paniculata (MPE), at doses of 100, 200, and 400 mg/kg...
August 25, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28836972/access-to-medicines-and-diagnostic-tests-integral-in-the-management-of-diabetes-mellitus-and-cardiovascular-diseases-in-uganda-insights-from-the-accodad-study
#20
Davis Kibirige, David Atuhe, Leaticia Kampiire, Daniel Ssekikubo Kiggundu, Pamela Donggo, Juliet Nabbaale, Raymond Mbayo Mwebaze, Robert Kalyesubula, William Lumu
BACKGROUND: Despite the burgeoning burden of diabetes mellitus (DM) and cardiovascular diseases (CVD) in low and middle income countries (LMIC), access to affordable essential medicines and diagnostic tests for DM and CVD still remain a challenge in clinical practice. The Access to Cardiovascular diseases, Chronic Obstructive pulmonary disease, Diabetes mellitus and Asthma Drugs and diagnostics (ACCODAD) study aimed at providing contemporary information about the availability, cost and affordability of medicines and diagnostic tests integral in the management of DM and CVD in Uganda...
August 24, 2017: International Journal for Equity in Health
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