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3D porous titanium

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https://www.readbyqxmd.com/read/29215451/mandibular-reconstruction-using-a-customized-three-dimensional-titanium-implant-applied-on-the-lingual-surface-of-the-mandible
#1
You-Young Jo, Seong-Gon Kim, Min-Keun Kim, Sung-Ho Shin, Janghoon Ahn, Hyun Seok
A patient had a right mandibular defect due to resection of an ameloblastoma. Previously, the defect had been reconstructed by an iliac bone graft, and subsequently, a titanium mesh with xenograft was used. However, it was not successfully reconstructed. For the recovery of mandible continuity and rehabilitation of jaw movement, we manufactured a customized 3-dimensional titanium implant by computer-aided design and manufacturing and electron beam melting technology. This implant was designed to have a porous body structure and lingual plate...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28884523/response-of-umbilical-cord-mesenchymal-stromal-cells-to-varying-titanium-topographical-signals
#2
Ines Lauria, Miriam Höner, Sebastian Kant, Roswitha Davtalab, Thomas Weik, Katrin Sternberg, Horst Fischer
A wide variety of titanium implant modifications have been developed to improve tissue- or cell-material interactions including bone bonding, implant failure, and contact osteogenesis. Osteogenesis can be stimulated by mechanobiological signals such as topography though translation of in vivo reactions to in vitro bioactivity and stem cell culture data, and vice versa, is challenging. We hypothesized that a systematic in vitro approach comparing clinically well-accepted implant surface topographical modifications could shed light on potential cell biological mechanisms provoked by submicron-, micron- or macrostructured surfaces...
September 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28832345/biomimetic-surface-functionalization-of-clinically-relevant-metals-used-as-orthopaedic-and-dental-implants
#3
Elena García-Gareta, Jia Hua, Alodia Orera, Nupur Kohli, Jonathan C Knowles, Gordon W Blunn
Titanium and its alloys or tantalum (Ta) are materials used in orthopaedic and dental implants due to their excellent mechanical properties and biocompatibility. However, their bioactivity and osteoconductivity is low. With a view to improving these materials bioactivity we hypothesised that the surface of Ta and TiAl6V4 can be functionalised with biomimetic, amorphous nano-sized calcium-phosphate (CaP) apatite-like deposits, instead of creating uniform coatings, which can lead to flaking, delamination and poor adherence...
August 23, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28797809/the-role-of-titanium-dioxide-on-the-morphology-microstructure-and-bioactivity-of-grafted-cellulose-hydroxyapatite-nanocomposites-for-a-potential-application-in-bone-repair
#4
Saeed Saber-Samandari, Hamed Yekta, Sara Ahmadi, Kadhim Alamara
Fabrication and characterization of a novel 3D nanocomposite scaffold have been reported in this research. The purpose of developing this new 3D nanocomposite scaffolds is introducing an alternative treatment for bone tissue replacement. Outcomes confirmed that the morphology, microstructure and mechanical properties of synthesized 3D nanocomposite scaffolds closely mimics the properties of real bone tissue. The 3D nanocomposite scaffolds compose of nanoparticle hydroxyapatite which is embedded in the semi-IPN of polyacrylamide-grafted cellulose by free radical polymerization...
August 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28765800/fortifying-the-bone-implant-interface-part-2-an-in-vivo-evaluation-of-3d-printed-and-tps-coated-triangular-implants
#5
Regina F MacBarb, Derek P Lindsey, Shane A Woods, Peggy A Lalor, Mukund I Gundanna, Scott A Yerby
BACKGROUND: Minimally invasive surgical fusion of the sacroiliac (SI) joint using machined solid triangular titanium plasma spray (TPS) coated implants has demonstrated positive clinical outcomes in SI joint pain patients. Additive manufactured (AM), i.e. 3D-printed, fenestrated triangular titanium implants with porous surfaces and bioactive agents, such as nanocrystalline hydroxyapatite (HA) or autograft, may further optimize bony fixation and subsequent biomechanical stability. METHODS: A bilateral ovine distal femoral defect model was used to evaluate the cancellous bone-implant interfaces of TPS-coated and AM implants...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28765799/fortifying-the-bone-implant-interface-part-1-an-in-vitro-evaluation-of-3d-printed-and-tps-porous-surfaces
#6
Regina F MacBarb, Derek P Lindsey, Chelsea S Bahney, Shane A Woods, Mark L Wolfe, Scott A Yerby
BACKGROUND: An aging society and concomitant rise in the incidence of impaired bone health have led to the need for advanced osteoconductive spinal implant surfaces that promote greater biological fixation (e.g. for interbody fusion cages, sacroiliac joint fusion implants, and artificial disc replacements). Additive manufacturing, i.e. 3D-printing, may improve bone integration by generating biomimetic spinal implant surfaces that mimic bone morphology. Such surfaces may foster an enhanced cellular response compared to traditional implant surfacing processes...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28689135/deformation-and-fatigue-of-tough-3d-printed-elastomer-scaffolds-processed-by-fused-deposition-modeling-and-continuous-liquid-interface-production
#7
Andrew T Miller, David L Safranski, Catherine Wood, Robert E Guldberg, Ken Gall
Polyurethane (PU) based elastomers continue to gain popularity in a variety of biomedical applications as compliant implant materials. In parallel, advancements in additive manufacturing continue to provide new opportunities for biomedical applications by enabling the creation of more complex architectures for tissue scaffolding and patient specific implants. The purpose of this study was to examine the effects of printed architecture on the monotonic and cyclic mechanical behavior of elastomeric PUs and to compare the structure-property relationship across two different printing approaches...
July 1, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28629601/a-custom-made-temporomandibular-joint-prosthesis-for-fabrication-by-selective-laser-melting-finite-element-analysis
#8
Xiangliang Xu, Danmei Luo, Chuanbin Guo, Qiguo Rong
A novel and custom-made selective laser melting (SLM) 3D-printed alloplastic temporomandibular joint (TMJ) prosthesis is proposed. The titanium-6aluminium-4vanadium (Ti-6Al-4V) condyle component and ultra-high molecular weight polyethylene (UHMWPE) fossa component comprised the total alloplastic TMJ replacement prosthesis. For the condyle component, an optimized tetrahedral open-porous scaffold with combined connection structures, i.e. an inlay rod and an onlay plate, between the prosthesis and remaining mandible was designed...
August 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28578109/reconstruction-of-thoracic-spine-using-a-personalized-3d-printed-vertebral-body-in-adolescent-with-t9-primary-bone-tumor
#9
Wen Jie Choy, Ralph J Mobbs, Ben Wilcox, Steven Phan, Kevin Phan, Chester E Sutterlin
BACKGROUND: Neurosurgery and spine surgery have the potential to benefit from the use of 3-dimensional printing (3DP) technology due to complex anatomic considerations and the delicate nature of surrounding structures. We report a procedure that uses a 3D-printed titanium T9 vertebral body implant post T9 vertebrectomy for a primary bone tumor. CASE DESCRIPTION: A 14-year-old female presented with progressive kyphoscoliosis and a pathologic fracture of the T9 vertebra with sagittal and coronal deformity due to a destructive primary bone tumor...
September 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28474182/homogenous-scaffold-based-cranial-skull-implant-modelling-and-structural-analysis-unit-cell-algorithm-meshless-approach
#10
V Phanindra Bogu, Y Ravi Kumar, Asit Kumar Khanra
This computational study explores a unique modelling approach of the cranial implant, homogenous scaffold algorithm and meshless method, respectively. This meshless method is employed to review the implant underneath intracranial pressure (ICP) conditions with a standard ICP range of 7 mm of Hg to 15 mm of Hg. The algorithm is used to introduce uniform porosity within the implant enabling the implant behaviour with respect to ICP conditions. However, increase in the porosity leads to variation in deformation and equivalent stress, respectively...
November 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28350023/topochemical-synthesis-and-photocatalytic-activity-of-3d-hierarchical-batio3-microspheres-constructed-from-crystal-axis-oriented-nanosheets
#11
Chang-Ke Chen, Shi-Xi Zhao, Qian-Long Lu, Kai Luo, Xi-Hui Zhang, Ce-Wen Nan
Novel BaTiO3 hierarchical porous microspheres were achieved by using H2Ti2O5·H2O (HTO) hierarchical microspheres as a precursor template via a facile solvothermal method. Interestingly, the BaTiO3 microspheres were constructed with two-dimensional (2D) nanosheets, which were composed of many order nanocrystals with crystal-axis-orientation. The special hierarchical structure, which is both macroporous and mesoporous, exhibits a large specific surface area and a high total pore volume. The photocatalytic performance of BaTiO3 hierarchical microspheres for degradation of methyl orange (MO) under UV-light irradiation was tested, its apparent rate being up to 0...
April 11, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28338421/harnessing-the-osteogenicity-of-in-vitro-stem-cell-derived-mineralized-extracellular-matrix-as-3d-biotemplate-to-guide-bone-regeneration
#12
Yoke Chin Chai, Johanna Bolander, Ioannis Papantoniou, Jennifer Patterson, Jef Vleugels, Jan Schrooten, Frank P Luyten
Advanced biomaterials that are capable of guiding robust bone regeneration are highly demanded for translational therapy of bone defects or bone augmentation in clinics. One of the strategic approaches is to produce tissue engineering (TE) constructs that mediate bone regeneration by recapitulating the natural bone formation or healing process. In this study, we aimed at producing devitalized mineralized carriers with augmented bone forming capacity via a modified culture protocol (i.e., culture conditions with high calcium and/or phosphate concentrations) that first promotes cell growth and, subsequently, mineralized extracellular matrix (ECM) deposition by human periosteum-derived osteoprogenitor cells (hPDCs) on additive manufactured three-dimensional (3D) porous titanium (Ti)-based scaffolds...
March 24, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28251470/3d-printed-porous-titanium-changed-femoral-head-repair-growth-patterns-osteogenesis-and-vascularisation-in-porous-titanium
#13
Wei Zhu, Yan Zhao, Qi Ma, Yingjie Wang, Zhihong Wu, Xisheng Weng
Osteonecrosis of the femoral head (ONFH) is a major cause of morbidity, and total hip arthroplasty is both traumatic and expensive. Here, we created a gelatine scaffold embedded in uniquely shaped, 3D-printed porous titanium parts, which could attract and promote the proliferation of osteoblasts as well as bone regeneration, as the extracellular matrix (ECM) does in vivo. Interestingly, after hybridisation with platelets, the scaffold exhibited a low yet considerable rate of stable, safe and long-term growth factor release...
April 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28196619/development-and-verification-of-novel-porous-titanium-metaphyseal-cones-for-revision-total-knee-arthroplasty
#14
Ahmad Faizan, Manoshi Bhowmik-Stoker, Vincent Alipit, Amanda E Kirk, Viktor E Krebs, Steven F Harwin, R Michael Meneghini
BACKGROUND: Porous metaphyseal cones are widely used in revision knee arthroplasty. A new system of porous titanium metaphyseal cones has been designed based on the femoral and tibial morphology derived from a computed tomography-based anatomical database. The purpose of this study is to evaluate the initial mechanical stability of the new porous titanium revision cone system by measuring the micromotion under physiologic loading compared with a widely-used existing porous tantalum metaphyseal cone system...
June 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28120579/sacral-reconstruction-with-a-3d-printed-implant-after-hemisacrectomy-in-a-patient-with-sacral-osteosarcoma-1-year-follow-up-result
#15
Doyoung Kim, Jun Young Lim, Kyu Won Shim, Jung Woo Han, Seong Yi, Do Heum Yoon, Keung Nyun Kim, Yoon Ha, Gyu Yeul Ji, Dong Ah Shin
Pelvic reconstruction after sacral resection is challenging in terms of anatomical complexity, excessive loadbearing, and wide defects. Nevertheless, the technological development of 3D-printed implants enables us to overcome these difficulties. Here, we present a case of sacral osteosarcoma surgically treated with hemisacrectomy and sacral reconstruction using a 3D-printed implant. The implant was printed as a customized titanium prosthesis from a 3D real-sized reconstruction of a patient's CT images. It consisted mostly of a porous mesh and incorporated a dense strut...
March 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27888725/functional-response-of-osteoblasts-in-functionally-gradient-titanium-alloy-mesh-arrays-processed-by-3d-additive-manufacturing
#16
K C Nune, A Kumar, R D K Misra, S J Li, Y L Hao, R Yang
We elucidate here the osteoblasts functions and cellular activity in 3D printed interconnected porous architecture of functionally gradient Ti-6Al-4V alloy mesh structures in terms of cell proliferation and growth, distribution of cell nuclei, synthesis of proteins (actin, vinculin, and fibronectin), and calcium deposition. Cell culture studies with pre-osteoblasts indicated that the interconnected porous architecture of functionally gradient mesh arrays was conducive to osteoblast functions. However, there were statistically significant differences in the cellular response depending on the pore size in the functionally gradient structure...
February 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27885781/cellular-response-of-osteoblasts-to-low-modulus-ti-24nb-4zr-8sn-alloy-mesh-structure
#17
K C Nune, R D K Misra, S J Li, Y L Hao, R Yang
Titanium alloys (Ti-6Al-4V and Ti-6Al-7Nb) are widely used for implants, which are characterized by high elastic modulus (∼110 GPa) with (α + β) structure and that may induce undesirable stress shielding effect and immune responses associated with the presence of toxic elements. In this regard, we have combined the attributes of a new alloy design and the concept of additive manufacturing to fabricate 3D scaffolds with an interconnected porous structure. The new alloy is a β-type Ti-24Nb-4Zr-8Sn (Ti2448) alloy with significantly reduced modulus...
March 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27788122/incorporating-simvastatin-poloxamer-407-hydrogel-into-3d-printed-porous-ti6al4v-scaffolds-for-the-promotion-of-angiogenesis-osseointegration-and-bone-ingrowth
#18
Hao Liu, Wei Li, Can Liu, Jie Tan, Hong Wang, Bao Hai, Hong Cai, Hui-Jie Leng, Zhong-Jun Liu, Chun-Li Song
Three-dimensional porous titanium alloys printed via electron beam melting have low stiffness similar to that of cortical bone and are promising scaffolds for orthopedic applications. However, the bio-inert nature of titanium alloy is poorly compatible with bone ingrowth. We previously observed that simvastatin/poloxamer 407 thermosensitive hydrogel induces endogenous angiogenic/osteogenic growth factors and promotes angiogenesis and osteogenesis, but the mechanical properties of this hydrogel are poor. The purpose of this study was to construct 3D-printed porous titanium scaffolds (pTi scaffolds) filled with simvastatin/hydrogel and evaluate the effects of this composite on osseointegration, bone ingrowth and neovascularization using a tibial defect rabbit model...
October 27, 2016: Biofabrication
https://www.readbyqxmd.com/read/27664796/fully-porous-3d-printed-titanium-femoral-stem-to-reduce-stress-shielding-following-total-hip-arthroplasty
#19
Sajad Arabnejad, Burnett Johnston, Michael Tanzer, Damiano Pasini
Current hip replacement femoral implants are made of fully solid materials which all have stiffness considerably higher than that of bone. This mechanical mismatch can cause significant bone resorption secondary to stress shielding, which can lead to serious complications such as peri-prosthetic fracture during or after revision surgery. In this work, a high strength fully porous material with tunable mechanical properties is introduced for use in hip replacement design. The implant macro geometry is based off of a short stem taper-wedge implant compatible with minimally invasive hip replacement surgery...
August 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27341499/tailored-surface-treatment-of-3d-printed-porous-ti6al4v-by-microarc-oxidation-for-enhanced-osseointegration-via-optimized-bone-in-growth-patterns-and-interlocked-bone-implant-interface
#20
Peng Xiu, Zhaojun Jia, Jia Lv, Chuan Yin, Yan Cheng, Ke Zhang, Chunli Song, Huijie Leng, Yufeng Zheng, Hong Cai, Zhongjun Liu
3D printed porous titanium (Ti) holds enormous potential for load-bearing orthopedic applications. Although the 3D printing technique has good control over the macro-sturctures of porous Ti, the surface properties that affect tissue response are beyond its control, adding the need for tailored surface treatment to improve its osseointegration capacity. Here, the one step microarc oxidation (MAO) process was applied to a 3D printed porous Ti6Al4V (Ti64) scaffold to endow the scaffold with a homogeneous layer of microporous TiO2 and significant amounts of amorphous calcium-phosphate...
July 20, 2016: ACS Applied Materials & Interfaces
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